Basic Information
Gene ID 6934 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name TCF7L2; TCF4
Full Name Transcription factor 7-like 2
Organism Homo sapiens [9606]

Cross Reference
UniProt Q9NQB0 UniGene Hs.593995
PDB 2GL7 OMIM 602228
KEGG hsa:6934 UCSC uc021pyj.1

Protein Interactions
DIP DIP-36236N
IntAct Q9NQB0
MINT MINT-222146
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
ENSEMBL
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ
REFSEQ

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSP00000348274 Gene3D G3DSA:1.10.30.10 IPR009071 348 430 9.30e-29 High mobility group box domain
ENSP00000348274 Gene3D G3DSA:4.10.900.10 IPR027397 1 60 1.40e-31 Catenin binding domain
ENSP00000348274 PANTHER PTHR10373 IPR024940 1 619 0.00e-00 Transcription factor TCF/LEF
ENSP00000348274 PANTHER PTHR10373:SF26 IPR028773 1 619 0.00e-00 Transcription factor 7-like 2
ENSP00000348274 Pfam PF00505 IPR009071 350 417 1.10e-21 High mobility group box domain
ENSP00000348274 Pfam PF08347 IPR013558 1 259 5.40e-90 CTNNB1 binding, N-teminal
ENSP00000348274 ProSiteProfiles PS50118 IPR009071 350 418 0.00e-00 High mobility group box domain
ENSP00000348274 SMART SM00398 IPR009071 349 419 3.90e-25 High mobility group box domain
ENSP00000348274 SUPERFAMILY SSF47095 IPR009071 349 430 0.00e-00 High mobility group box domain

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSP00000348274 PF08347 0 CTNNB1_binding N-terminal CTNNB1 binding
ENSP00000348274 PF00505 5.7e-22 HMG_box HMG (high mobility group) box
ENSP00000348274 PF09011 9.6e-08 HMG_box_2 HMG-box domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSP00000348274 GO:0006351 biological_process transcription, DNA-templated
ENSP00000348274 GO:0006355 biological_process regulation of transcription, DNA-templated
ENSP00000348274 GO:0006357 biological_process regulation of transcription from RNA polymerase II promoter
ENSP00000348274 GO:0007275 biological_process multicellular organismal development
ENSP00000348274 GO:0016055 biological_process Wnt signaling pathway
ENSP00000348274 GO:0060070 biological_process canonical Wnt signaling pathway
ENSP00000348274 GO:0005634 cellular_component nucleus
ENSP00000348274 GO:0003677 molecular_function DNA binding
ENSP00000348274 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSP00000348274 GO:0008013 molecular_function beta-catenin binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
7425 Nasonia vitripennis 100120687 9597 Pan paniscus 100978424
9555 Papio anubis 101026705 10090 Mus musculus 21416
7668 Strongylocentrotus purpuratus 373203 7227 Drosophila melanogaster 43769
7029 Acyrthosiphon pisum 100161896 6087 Hydra magnipapillata 100199257
10224 Saccoglossus kowalevskii 100303556 400682 Amphimedon queenslandica 100641322
8090 Oryzias latipes 100820729 34638 Metaseiulus occidentalis 100905988
39432 Saimiri boliviensis 101037011 13735 Pelodiscus sinensis 102459521
6239 Caenorhabditis elegans 171849 7070 Tribolium castaneum 641465
9615 Canis familiaris ENSCAFG00000011005 10141 Cavia porcellus ENSCPOG00000002152
51511 Ciona savignyi ENSCSAVG00000007833 10020 Dipodomys ordii ENSDORG00000011398
9365 Erinaceus europaeus ENSEEUG00000007595 9595 Gorilla gorilla ENSGGOG00000008549
7897 Latimeria chalumnae ENSLACG00000015707 9785 Loxodonta africana ENSLAFG00000018192
59463 Myotis lucifugus ENSMLUG00000008783 9669 Mustela putorius furo ENSMPUG00000002032
61853 Nomascus leucogenys ENSNLEG00000015863 9986 Oryctolagus cuniculus ENSOCUG00000008142
30611 Otolemur garnettii ENSOGAG00000014475 9813 Procavia capensis ENSPCAG00000012331
7757 Petromyzon marinus ENSPMAG00000004519 132908 Pteropus vampyrus ENSPVAG00000016688
10116 Rattus norvegicus ENSRNOG00000049232 9305 Sarcophilus harrisii ENSSHAG00000017344
9823 Sus scrofa ENSSSCG00000010638 43179 Ictidomys tridecemlineatus ENSSTOG00000006847
37347 Tupaia belangeri ENSTBEG00000002995 99883 Tetraodon nigroviridis ENSTNIG00000006080
31033 Takifugu rubripes ENSTRUG00000012549 9478 Tarsius syrichta ENSTSYG00000012796
8364 Xenopus tropicalis ENSXETG00000018735 8083 Xiphophorus maculatus ENSXMAG00000014710
28377 Anolis carolinensis ENSACAG00000010433 9646 Ailuropoda melanoleuca ENSAMEG00000015382
9913 Bos taurus ENSBTAG00000021574 9358 Choloepus hoffmanni ENSCHOG00000005968
7719 Ciona intestinalis ENSCING00000002003 9483 Callithrix jacchus ENSCJAG00000018987
7955 Danio rerio ENSDARG00000004415 9361 Dasypus novemcinctus ENSDNOG00000012035
9796 Equus caballus ENSECAG00000024121 9371 Echinops telfairi ENSETEG00000018612
9685 Felis catus ENSFCAG00000018774 69293 Gasterosteus aculeatus ENSGACG00000011184
9031 Gallus gallus ENSGALG00000026476 8049 Gadus morhua ENSGMOG00000018031
9315 Macropus eugenii ENSMEUG00000011191 9103 Meleagris gallopavo ENSMGAG00000005753
30608 Microcebus murinus ENSMICG00000007510 9544 Macaca mulatta ENSMMUG00000022799
13616 Monodelphis domestica ENSMODG00000010133 9258 Ornithorhynchus anatinus ENSOANG00000001579
8128 Oreochromis niloticus ENSONIG00000016240 9978 Ochotona princeps ENSOPRG00000005139
9601 Pongo abelii ENSPPYG00000002661 9598 Pan troglodytes ENSPTRG00000002949
42254 Sorex araneus ENSSARG00000012174 59729 Taeniopygia guttata ENSTGUG00000010805
9739 Tursiops truncatus ENSTTRG00000002360 30538 Vicugna pacos ENSVPAG00000008158