Basic Information
Gene ID ENSLAFG00000005970
Gene Name STAT6
Full Name Signal transducer and activator of transcription
Organism Loxodonta africana [9785]

Cross Reference
UniProt G3SX92 UniGene NULL
PDB NULL OMIM NULL
KEGG NULL UCSC NULL

Protein Interactions
DIP NULL
IntAct NULL
MINT NULL
STRING NULL

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSLAFP00000005009 Gene3D G3DSA:1.10.238.10 IPR011992 418 543 2.60e-41 EF-hand domain pair
ENSLAFP00000005009 Gene3D G3DSA:1.10.532.10 IPR013799 1 113 2.40e-22 STAT transcription factor, protein interaction
ENSLAFP00000005009 Gene3D G3DSA:1.20.1050.20 IPR013800 114 275 3.80e-27 STAT transcription factor, all-alpha
ENSLAFP00000005009 Gene3D G3DSA:2.60.40.630 IPR012345 277 417 3.00e-44 STAT transcription factor, DNA-binding, subdomain
ENSLAFP00000005009 Gene3D G3DSA:3.30.505.10 IPR000980 544 652 6.70e-37 SH2 domain
ENSLAFP00000005009 PANTHER PTHR11801 IPR001217 2 720 0.00e-00 Transcription factor STAT
ENSLAFP00000005009 Pfam PF00017 IPR000980 540 618 3.70e-10 SH2 domain
ENSLAFP00000005009 Pfam PF01017 IPR013800 128 273 6.10e-23 STAT transcription factor, all-alpha
ENSLAFP00000005009 Pfam PF02864 IPR013801 275 529 2.00e-93 STAT transcription factor, DNA-binding
ENSLAFP00000005009 Pfam PF02865 IPR013799 2 114 9.70e-23 STAT transcription factor, protein interaction
ENSLAFP00000005009 Pfam PF14596 IPR028187 657 849 6.50e-95 STAT6, C-terminal
ENSLAFP00000005009 ProSiteProfiles PS50001 IPR000980 519 634 0.00e-00 SH2 domain
ENSLAFP00000005009 SMART SM00252 IPR000980 542 624 1.60e-07 SH2 domain
ENSLAFP00000005009 SMART SM00964 IPR013799 2 116 9.20e-39 STAT transcription factor, protein interaction
ENSLAFP00000005009 SUPERFAMILY SSF47655 IPR015988 112 275 0.00e-00 STAT transcription factor, coiled coil
ENSLAFP00000005009 SUPERFAMILY SSF48092 IPR013799 1 115 0.00e-00 STAT transcription factor, protein interaction
ENSLAFP00000005009 SUPERFAMILY SSF49417 IPR008967 267 530 0.00e-00 p53-like transcription factor, DNA-binding

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSLAFP00000005009 PF02864 0 STAT_bind STAT protein, DNA binding domain
ENSLAFP00000005009 PF14596 0 STAT6_C STAT6 C-terminal
ENSLAFP00000005009 PF01017 7.4e-25 STAT_alpha STAT protein, all-alpha domain
ENSLAFP00000005009 PF02865 3e-23 STAT_int STAT protein, protein interaction domain
ENSLAFP00000005009 PF00017 1.6e-10 SH2 SH2 domain

Gene Ontology Annotation
Protein Entry Name Space Description
ENSLAFP00000005009 GO:0001553 biological_process luteinization
ENSLAFP00000005009 GO:0001779 biological_process natural killer cell differentiation
ENSLAFP00000005009 GO:0006351 biological_process transcription, DNA-templated
ENSLAFP00000005009 GO:0007259 biological_process JAK-STAT cascade
ENSLAFP00000005009 GO:0007565 biological_process female pregnancy
ENSLAFP00000005009 GO:0007595 biological_process lactation
ENSLAFP00000005009 GO:0019218 biological_process regulation of steroid metabolic process
ENSLAFP00000005009 GO:0019915 biological_process lipid storage
ENSLAFP00000005009 GO:0030155 biological_process regulation of cell adhesion
ENSLAFP00000005009 GO:0030856 biological_process regulation of epithelial cell differentiation
ENSLAFP00000005009 GO:0038161 biological_process prolactin signaling pathway
ENSLAFP00000005009 GO:0040018 biological_process positive regulation of multicellular organism growth
ENSLAFP00000005009 GO:0042104 biological_process positive regulation of activated T cell proliferation
ENSLAFP00000005009 GO:0043029 biological_process T cell homeostasis
ENSLAFP00000005009 GO:0045086 biological_process positive regulation of interleukin-2 biosynthetic process
ENSLAFP00000005009 GO:0045579 biological_process positive regulation of B cell differentiation
ENSLAFP00000005009 GO:0045647 biological_process negative regulation of erythrocyte differentiation
ENSLAFP00000005009 GO:0045931 biological_process positive regulation of mitotic cell cycle
ENSLAFP00000005009 GO:0045944 biological_process positive regulation of transcription from RNA polymerase II promoter
ENSLAFP00000005009 GO:0046543 biological_process development of secondary female sexual characteristics
ENSLAFP00000005009 GO:0050729 biological_process positive regulation of inflammatory response
ENSLAFP00000005009 GO:0005634 cellular_component nucleus
ENSLAFP00000005009 GO:0005737 cellular_component cytoplasm
ENSLAFP00000005009 GO:0003700 molecular_function sequence-specific DNA binding transcription factor activity
ENSLAFP00000005009 GO:0004871 molecular_function signal transducer activity
ENSLAFP00000005009 GO:0005509 molecular_function calcium ion binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9483 Callithrix jacchus ENSCJAG00000010327 9796 Equus caballus 100050053
9823 Sus scrofa 100627682 10029 Cricetulus griseus 100753838
30611 Otolemur garnettii 100949888 9597 Pan paniscus 100989067
9555 Papio anubis 101023204 39432 Saimiri boliviensis 101029869
9685 Felis catus 101089873 9595 Gorilla gorilla 101130575
9669 Mustela putorius furo 101676980 43179 Ictidomys tridecemlineatus 101967693
9544 Macaca mulatta 714159 28377 Anolis carolinensis ENSACAG00000009680
10020 Dipodomys ordii ENSDORG00000012548 9365 Erinaceus europaeus ENSEEUG00000005856
9371 Echinops telfairi ENSETEG00000014957 9315 Macropus eugenii ENSMEUG00000016670
59463 Myotis lucifugus ENSMLUG00000006689 13616 Monodelphis domestica ENSMODG00000019411
61853 Nomascus leucogenys ENSNLEG00000017396 9978 Ochotona princeps ENSOPRG00000013409
9813 Procavia capensis ENSPCAG00000009432 9601 Pongo abelii ENSPPYG00000004680
132908 Pteropus vampyrus ENSPVAG00000003949 42254 Sorex araneus ENSSARG00000001630
37347 Tupaia belangeri ENSTBEG00000013664 59729 Taeniopygia guttata ENSTGUG00000015716
9478 Tarsius syrichta ENSTSYG00000000267 9739 Tursiops truncatus ENSTTRG00000013064
8364 Xenopus tropicalis ENSXETG00000004431 30608 Microcebus murinus ENSMICG00000009087
9598 Pan troglodytes ENSPTRG00000005121