Basic Information
Gene ID ENSMUSG00000048154 ; Check Expression Profles ; Check TFs & Targets Binding
Gene Name Kmt2d; Mll2, Mll4
Full Name Histone-lysine N-methyltransferase 2D
Organism Mus musculus [10090]

Cross Reference
UniProt Q6PDK2 UniGene Mm.264889
PDB NULL OMIM NULL
KEGG NULL UCSC uc029suy.1

Protein Interactions
DIP NULL
IntAct Q6PDK2
MINT NULL
STRING 10090.ENSMUSP00000023741

Ensembl/RefSeq
Transcript ID
Protein ID
Gene ID
ENSEMBL
ENSEMBL

InterPro Annotation
Protein Program Term IPRS Start End Score Description
ENSMUSP00000135941 Gene3D G3DSA:3.30.40.10 IPR013083 1332 1383 6.30e-08 Zinc finger, RING/FYVE/PHD-type
ENSMUSP00000135941 Gene3D G3DSA:3.30.40.10 IPR013083 1384 1431 3.30e-14 Zinc finger, RING/FYVE/PHD-type
ENSMUSP00000135941 Gene3D G3DSA:3.30.40.10 IPR013083 1461 1514 1.20e-07 Zinc finger, RING/FYVE/PHD-type
ENSMUSP00000135941 Gene3D G3DSA:3.30.40.10 IPR013083 216 274 3.00e-09 Zinc finger, RING/FYVE/PHD-type
ENSMUSP00000135941 Gene3D G3DSA:3.30.40.10 IPR013083 275 321 2.60e-12 Zinc finger, RING/FYVE/PHD-type
ENSMUSP00000135941 Pfam PF00628 IPR019787 1335 1384 2.90e-07 Zinc finger, PHD-finger
ENSMUSP00000135941 Pfam PF00628 IPR019787 1385 1432 3.30e-09 Zinc finger, PHD-finger
ENSMUSP00000135941 Pfam PF00628 IPR019787 275 321 1.40e-08 Zinc finger, PHD-finger
ENSMUSP00000135941 Pfam PF00856 IPR001214 5459 5564 3.20e-24 SET domain
ENSMUSP00000135941 Pfam PF05964 IPR003888 5231 5283 7.80e-21 FY-rich, N-terminal
ENSMUSP00000135941 Pfam PF05965 IPR003889 5288 5374 3.70e-25 FY-rich, C-terminal
ENSMUSP00000135941 ProSiteProfiles PS50016 IPR019787 1333 1386 0.00e-00 Zinc finger, PHD-finger
ENSMUSP00000135941 ProSiteProfiles PS50016 IPR019787 1383 1433 0.00e-00 Zinc finger, PHD-finger
ENSMUSP00000135941 ProSiteProfiles PS50016 IPR019787 1460 1515 0.00e-00 Zinc finger, PHD-finger
ENSMUSP00000135941 ProSiteProfiles PS50016 IPR019787 270 323 0.00e-00 Zinc finger, PHD-finger
ENSMUSP00000135941 ProSiteProfiles PS50089 IPR001841 229 274 0.00e-00 Zinc finger, RING-type
ENSMUSP00000135941 ProSiteProfiles PS50280 IPR001214 5448 5564 0.00e-00 SET domain
ENSMUSP00000135941 ProSiteProfiles PS50868 IPR003616 5572 5588 0.00e-00 Post-SET domain
ENSMUSP00000135941 ProSiteProfiles PS51542 IPR003888 5226 5286 0.00e-00 FY-rich, N-terminal
ENSMUSP00000135941 ProSiteProfiles PS51543 IPR003889 5287 5372 0.00e-00 FY-rich, C-terminal
ENSMUSP00000135941 SMART SM00184 IPR001841 1336 1383 5.60e-02 Zinc finger, RING-type
ENSMUSP00000135941 SMART SM00184 IPR001841 1463 1512 5.60e-02 Zinc finger, RING-type
ENSMUSP00000135941 SMART SM00184 IPR001841 172 217 7.60e-03 Zinc finger, RING-type
ENSMUSP00000135941 SMART SM00184 IPR001841 229 273 7.80e-06 Zinc finger, RING-type
ENSMUSP00000135941 SMART SM00184 IPR001841 276 320 8.90e-03 Zinc finger, RING-type
ENSMUSP00000135941 SMART SM00184 IPR001841 5143 5187 1.90e-02 Zinc finger, RING-type
ENSMUSP00000135941 SMART SM00249 IPR001965 1335 1384 3.50e-11 Zinc finger, PHD-type
ENSMUSP00000135941 SMART SM00249 IPR001965 1385 1431 4.30e-15 Zinc finger, PHD-type
ENSMUSP00000135941 SMART SM00249 IPR001965 1462 1513 5.70e-09 Zinc finger, PHD-type
ENSMUSP00000135941 SMART SM00249 IPR001965 171 218 8.10e-08 Zinc finger, PHD-type
ENSMUSP00000135941 SMART SM00249 IPR001965 228 274 1.10e-10 Zinc finger, PHD-type
ENSMUSP00000135941 SMART SM00249 IPR001965 275 321 7.80e-14 Zinc finger, PHD-type
ENSMUSP00000135941 SMART SM00249 IPR001965 5142 5188 2.40e-07 Zinc finger, PHD-type
ENSMUSP00000135941 SMART SM00317 IPR001214 5448 5570 2.80e-38 SET domain
ENSMUSP00000135941 SMART SM00398 IPR009071 1969 2037 2.10e-08 High mobility group box domain
ENSMUSP00000135941 SMART SM00508 IPR003616 5572 5588 1.40e-07 Post-SET domain
ENSMUSP00000135941 SMART SM00541 IPR003888 5242 5285 1.70e-23 FY-rich, N-terminal
ENSMUSP00000135941 SMART SM00542 IPR003889 5291 5378 8.60e-46 FY-rich, C-terminal
ENSMUSP00000135941 SUPERFAMILY SSF47095 IPR009071 1979 2029 0.00e-00 High mobility group box domain
ENSMUSP00000135941 SUPERFAMILY SSF57903 IPR011011 1330 1384 0.00e-00 Zinc finger, FYVE/PHD-type
ENSMUSP00000135941 SUPERFAMILY SSF57903 IPR011011 1376 1436 0.00e-00 Zinc finger, FYVE/PHD-type
ENSMUSP00000135941 SUPERFAMILY SSF57903 IPR011011 1451 1520 0.00e-00 Zinc finger, FYVE/PHD-type
ENSMUSP00000135941 SUPERFAMILY SSF57903 IPR011011 215 277 0.00e-00 Zinc finger, FYVE/PHD-type
ENSMUSP00000135941 SUPERFAMILY SSF57903 IPR011011 273 326 0.00e-00 Zinc finger, FYVE/PHD-type

Pfam Annotation
Protein Pfam ID E.value Name Description
ENSMUSP00000135941 PF00628 7.5e-34 PHD PHD-finger
ENSMUSP00000135941 PF05965 9.2e-26 FYRC F/Y rich C-terminus
ENSMUSP00000135941 PF00856 3.2e-24 SET SET domain
ENSMUSP00000135941 PF13771 3.3e-22 zf-HC5HC2H PHD-like zinc-binding domain
ENSMUSP00000135941 PF05964 4.2e-21 FYRN F/Y-rich N-terminus
ENSMUSP00000135941 PF13832 2.3e-10 zf-HC5HC2H_2 PHD-zinc-finger like domain
ENSMUSP00000135941 PF00505 0.00046 HMG_box HMG (high mobility group) box

Gene Ontology Annotation
Protein Entry Name Space Description
ENSMUSP00000135941 GO:0051568 biological_process histone H3-K4 methylation
ENSMUSP00000135941 GO:0005634 cellular_component nucleus
ENSMUSP00000135941 GO:0035097 cellular_component histone methyltransferase complex
ENSMUSP00000135941 GO:0008270 molecular_function zinc ion binding

Orthologs
TAXID Organism Gene ID TAXID Organism Gene ID
9597 Pan paniscus 100995808 9555 Papio anubis 101013975
39432 Saimiri boliviensis 101037539 9615 Canis familiaris 486558
9606 Homo sapiens 8085 28377 Anolis carolinensis ENSACAG00000014195
9646 Ailuropoda melanoleuca ENSAMEG00000006918 9913 Bos taurus ENSBTAG00000014429
9483 Callithrix jacchus ENSCJAG00000020845 10141 Cavia porcellus ENSCPOG00000002973
7955 Danio rerio ENSDARG00000075560 10020 Dipodomys ordii ENSDORG00000006509
9796 Equus caballus ENSECAG00000022544 9365 Erinaceus europaeus ENSEEUG00000007930
9371 Echinops telfairi ENSETEG00000001399 9685 Felis catus ENSFCAG00000000093
69293 Gasterosteus aculeatus ENSGACG00000013375 9031 Gallus gallus ENSGALG00000006264
9595 Gorilla gorilla ENSGGOG00000007949 8049 Gadus morhua ENSGMOG00000003449
7897 Latimeria chalumnae ENSLACG00000009033 9785 Loxodonta africana ENSLAFG00000009989
9103 Meleagris gallopavo ENSMGAG00000004716 30608 Microcebus murinus ENSMICG00000017547
59463 Myotis lucifugus ENSMLUG00000011179 9544 Macaca mulatta ENSMMUG00000015718
9669 Mustela putorius furo ENSMPUG00000014629 9986 Oryctolagus cuniculus ENSOCUG00000006202
9978 Ochotona princeps ENSOPRG00000015259 7757 Petromyzon marinus ENSPMAG00000002099
61853 Nomascus leucogenys ENSNLEG00000017849 9258 Ornithorhynchus anatinus ENSOANG00000006160
30611 Otolemur garnettii ENSOGAG00000013443 8128 Oreochromis niloticus ENSONIG00000009769
8090 Oryzias latipes ENSORLG00000003857 9813 Procavia capensis ENSPCAG00000003597
9601 Pongo abelii ENSPPYG00000004478 9598 Pan troglodytes ENSPTRG00000004896
132908 Pteropus vampyrus ENSPVAG00000008322 10116 Rattus norvegicus ENSRNOG00000015107
42254 Sorex araneus ENSSARG00000010487 9305 Sarcophilus harrisii ENSSHAG00000011852
9823 Sus scrofa ENSSSCG00000000191 43179 Ictidomys tridecemlineatus ENSSTOG00000003904
37347 Tupaia belangeri ENSTBEG00000001207 59729 Taeniopygia guttata ENSTGUG00000000616
99883 Tetraodon nigroviridis ENSTNIG00000015229 31033 Takifugu rubripes ENSTRUG00000005765
9478 Tarsius syrichta ENSTSYG00000014542 9739 Tursiops truncatus ENSTTRG00000004737
30538 Vicugna pacos ENSVPAG00000001618 8364 Xenopus tropicalis ENSXETG00000011176
8083 Xiphophorus maculatus ENSXMAG00000016422