PredictBias

identification of genomic and pathogenicity islands in prokaryotic genome
Home | Help | Analyzed genomes
 
A) Input parameters
GenomeB38.gbkThreshold dinucleotide bias2
Threshold codon bias4Threshold %GC bias3
E-value (RPSBlast)0.05Genome (non-pathogenic)
 
B) Compare a potential GI or PAI in related non-pathogenic sp. (phylogenetic tree)
Potential GI or PAI start    end  
Select Organism     
 
C) Potential GIs and PAIs in FM991728 (download)
S.NoStartEndBiasVirulenceInsertion elementsPrediction
1HELPY_0047HELPY_0076Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_00472120.321828Symporter, SSS family (Proline Permease);
HELPY_0049212-0.032287Bifunctional protein PutA [Proline dehydrogenase
HELPY_0050416-0.636864Conserved hypothetical protein; putative signal
HELPY_0051416-0.499305Conserved hypothetical protein
HELPY_00523140.173442Conserved hypothetical protein
HELPY_0053115-0.067441Conserved hypothetical protein
HELPY_0054215-0.217258Conserved hypothetical protein
HELPY_0056417-1.583036Conserved hypothetical protein
HELPY_00581160.602682Conserved hypothetical protein
HELPY_00591151.571646Conserved hypothetical protein
HELPY_00600151.702194Urease accessory protein UreH
HELPY_00610151.735975Urease accessory protein UreG
HELPY_00621152.755202Urease accessory protein UreF
HELPY_00634203.447009Urease accessory protein UreE
HELPY_00654202.284925Urease accessory protein ureI
HELPY_00673192.571866Urease B subunit
HELPY_0069-291.642005Urease A subunit
HELPY_00710132.130822*Lipoprotein signal peptidase (Prolipoprotein
HELPY_00722132.606321Phosphoglucosamine mutase
HELPY_00733121.83855930S ribosomal subunit protein S20
HELPY_00742131.998225Peptide chain release factor 1 (RF-1)
HELPY_00754131.784942Conserved hypothetical protein; putative signal
HELPY_00763131.618884Methyl-accepting chemotaxis protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0049ANTHRAXTOXNA310.027 Anthrax toxin LF subunit signature.
		>ANTHRAXTOXNA#Anthrax toxin LF subunit signature.

Length = 800

Score = 31.3 bits (70), Expect = 0.027
Identities = 36/173 (20%), Positives = 71/173 (41%), Gaps = 19/173 (10%)

Query: 121 QEESQLKERILKRKNEKIILNVNFIGEEVLGEEEASARFEKY---SQALKSNYIQYISIK 177
Q+ S+ ++ + + EK+ F+ E+ + + Y S+ K Y +
Sbjct: 118 QDLSEEEKNSMNSRGEKVPFASRFVFEKKRETPKLIINIKDYAINSEQSKEVYYEIGKGI 177

Query: 178 ITTIFSQINILDFEY-----SKKEIVKRLDALYALALEEEKKQGMPKFINLDMEEFRDLE 232
I S+ LD E+ S + D L++ +E K + K I+++ ++
Sbjct: 178 SLDIISKDKSLDPEFLNLIKSLSDDSDSSDLLFSQKFKE-KLELNNKSIDINF-----IK 231

Query: 233 LTVESFMESIAK-----FDLNAGIVLQAYIPDSYEYLKKLHAFSKERVLKGLK 280
+ F + + F + VL+ Y PD +EY+ KL E++ + LK
Sbjct: 232 ENLTEFQHAFSLAFSYYFAPDHRTVLELYAPDMFEYMNKLEKGGFEKISESLK 284


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0051GPOSANCHOR461e-07 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 46.2 bits (109), Expect = 1e-07
Identities = 40/209 (19%), Positives = 74/209 (35%)

Query: 10 QENPKDAQKKEEALKKLQEENTALNRDKNDLAREKDKLADQNKTLIETNQKLTTEKERLE 69
+ + + ++ +L EE + + + A + + L L E
Sbjct: 74 SDLSFNNKALKDHNDELTEELSNAKEKLRKNDKSLSEKASKIQELEARKADLEKALEGAM 133

Query: 70 RENKNLTAEKENLTKEKTELTNKNAELQKQVKALEQSQQALKNGNDELLKDREKLTTQNT 129
+ +A+ + L EK L + A+L+K ++ A L ++ L +
Sbjct: 134 NFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQA 193

Query: 130 ELAEKIKALTTEKTELNNKITRLTTDKENLTKDKENLTTALSTAKTQAEQTSQKLNELER 189
EL + ++ T + KI L +K L K +L AL A + S K+ LE
Sbjct: 194 ELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEA 253

Query: 190 RHAPYQKLEKLYEVFLEVKDRLNFNFVAT 218
A + + E LE + A
Sbjct: 254 EKAALEARQAELEKALEGAMNFSTADSAK 282



Score = 42.7 bits (100), Expect = 1e-06
Identities = 27/190 (14%), Positives = 59/190 (31%)

Query: 7 NDTQENPKDAQKKEEALKKLQEENTALNRDKNDLAREKDKLADQNKTLIETNQKLTTEKE 66
+ + +K +++L + + L K DL + + + + + L EK
Sbjct: 92 EELSNAKEKLRKNDKSLSEKASKIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKA 151

Query: 67 RLERENKNLTAEKENLTKEKTELTNKNAELQKQVKALEQSQQALKNGNDELLKDREKLTT 126
L +L E T + K L+ + ALE Q L+ + + +
Sbjct: 152 ALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSA 211

Query: 127 QNTELAEKIKALTTEKTELNNKITRLTTDKENLTKDKENLTTALSTAKTQAEQTSQKLNE 186
+ L + AL K +L + + + L + + + + + L
Sbjct: 212 KIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEG 271

Query: 187 LERRHAPYQK 196

Sbjct: 272 AMNFSTADSA 281



Score = 40.4 bits (94), Expect = 6e-06
Identities = 30/183 (16%), Positives = 59/183 (32%), Gaps = 7/183 (3%)

Query: 17 QKKEEALKKLQEENTALNRDKNDLAREKDKLADQNKTLIETNQKLTTEKERLERENKNLT 76
L++ + + L + L +L E + +
Sbjct: 151 AALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADS 210

Query: 77 AEKENLTKEKTELTNKNAELQKQVKALEQSQQALKNGNDELLKDREKLTTQNTELAEKIK 136
A+ + L EK L + A+L+K ++ A L ++ L + EL + ++
Sbjct: 211 AKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALE 270

Query: 137 ALTTEKTELNNKITRLTTDKENLTKDKENLTTALSTAKTQAEQTSQKLN-------ELER 189
T + KI L +K L +K +L + + L+ +LE
Sbjct: 271 GAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEA 330

Query: 190 RHA 192
H
Sbjct: 331 EHQ 333



Score = 33.1 bits (75), Expect = 0.001
Identities = 39/193 (20%), Positives = 73/193 (37%)

Query: 10 QENPKDAQKKEEALKKLQEENTALNRDKNDLAREKDKLADQNKTLIETNQKLTTEKERLE 69
+ + +K L+ E AL + +L + + + + + L EK LE
Sbjct: 235 EGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALE 294

Query: 70 RENKNLTAEKENLTKEKTELTNKNAELQKQVKALEQSQQALKNGNDELLKDREKLTTQNT 129
E +L + + L + L ++ K LE Q L+ N R+ L
Sbjct: 295 AEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLD 354

Query: 130 ELAEKIKALTTEKTELNNKITRLTTDKENLTKDKENLTTALSTAKTQAEQTSQKLNELER 189
E K L E +L + +++L +D + A + E+ + KL LE+
Sbjct: 355 ASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQVEKALEEANSKLAALEK 414

Query: 190 RHAPYQKLEKLYE 202
+ ++ +KL E
Sbjct: 415 LNKELEESKKLTE 427


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0052GPOSANCHOR383e-05 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 38.1 bits (88), Expect = 3e-05
Identities = 47/269 (17%), Positives = 93/269 (34%), Gaps = 2/269 (0%)

Query: 13 QIREELEARIGELEDENAELFTTKEKLTKENTELAYKNNKLFKENEKISGLENANDQLWQ 72
+E+L L ++ +++ + + L N ++ KI LE L
Sbjct: 96 NAKEKLRKNDKSLSEKASKIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAA 155

Query: 73 AKDKLTKENTELTHKNAELLRERDNLAKENTELASKTAALTEKTAELKTENDKLNHLVIA 132
K L K + + + L E L ++ A L + + + +
Sbjct: 156 RKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKT 215

Query: 133 LNNEQGSLKQERAKLQEEHGFLEKRCTNLEKENQRLTDKLKKLESTQKNLENTNNQLRQS 192
L E+ +L +A L++ T + + L + LE+ Q LE
Sbjct: 216 LEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNF 275

Query: 193 LENSNDQLLQAKEKIAEENTELEREIARLKSLETMEEKSKLDLHNRRLASANQDLKRQNR 252
+ ++ + + A E + + L + + DL R A + L+ +++
Sbjct: 276 STADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASR--EAKKQLEAEHQ 333

Query: 253 KLEEENIALKERAYGLNEQLFTLQPQKPQ 281
KLEE+N + L L + K Q
Sbjct: 334 KLEEQNKISEASRQSLRRDLDASREAKKQ 362



Score = 35.0 bits (80), Expect = 3e-04
Identities = 48/264 (18%), Positives = 89/264 (33%), Gaps = 5/264 (1%)

Query: 16 EELEARIGELEDENAELFTTKEKLTKENTELAYKNNKLFKENEKISGLENANDQLWQAKD 75
+ L+ EL +E + KEKL K + L+ K +K+ + + + LE A +
Sbjct: 81 KALKDHNDELTEELSNA---KEKLRKNDKSLSEKASKIQELEARKADLEKALEGAMNFST 137

Query: 76 KLTKENTELTHKNAELLRERDNLAKENTELASKTAALTEKTAELKTENDKLNHLVIALNN 135
+ + L + A L + +L K + + A + K L+ E L L
Sbjct: 138 ADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEK 197

Query: 136 EQGSLKQERAKLQEEHGFLEKRCTNLEKENQRLTDKLKKLESTQKNLENTNNQLRQSLEN 195
+ LE L L L+ + L
Sbjct: 198 ALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAA 257

Query: 196 SNDQLLQAKEKIAEENTELEREIARLKSLETMEEKSKLDLHNRRLASANQDLKRQNRKLE 255
+ + ++ + + A++K+LE EK+ L+ L +Q L + L
Sbjct: 258 LEARQAELEKALEGAMNFSTADSAKIKTLEA--EKAALEAEKADLEHQSQVLNANRQSLR 315

Query: 256 EENIALKERAYGLNEQLFTLQPQK 279
+ A +E L + L+ Q
Sbjct: 316 RDLDASREAKKQLEAEHQKLEEQN 339



Score = 33.1 bits (75), Expect = 0.001
Identities = 34/209 (16%), Positives = 68/209 (32%), Gaps = 2/209 (0%)

Query: 73 AKDKLTKENTELTHKNAELLRERDNLAKENTELASKTAALTEKTAELKTENDKLNHLVIA 132
DK EN L KN++L L N EL + + EK + + +
Sbjct: 58 RADKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLRKNDKSLSEKASKIQE 117

Query: 133 LNNEQGSLKQERAKLQEEHGFLEKRCTNLEKENQRLTDKLKKLESTQKNLENTNNQLRQS 192
L + L++ + LE E L + LE + N +
Sbjct: 118 LEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAK 177

Query: 193 LENSNDQLLQAKEKIAEENTELEREIARLKSLETMEEKSKLDLHNRRLASANQDLKRQNR 252
++ + + + AE LE + + + + + LA+ DL++
Sbjct: 178 IKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEK--AALAARKADLEKALE 235

Query: 253 KLEEENIALKERAYGLNEQLFTLQPQKPQ 281
+ A + L + L+ ++ +
Sbjct: 236 GAMNFSTADSAKIKTLEAEKAALEARQAE 264



Score = 33.1 bits (75), Expect = 0.001
Identities = 57/272 (20%), Positives = 94/272 (34%), Gaps = 15/272 (5%)

Query: 13 QIREELEARIGELEDENAELFTTKEKLTKENTELAYKNNKLFKENEKISGLENANDQLWQ 72
+ +LE + + + + L E LA + L K E G N +
Sbjct: 120 ARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALE---GAMNFSTADSA 176

Query: 73 AKDKLTKENTELTHKNAELLRERDNLAKENTELASKTAALTEKTAELKTENDKLNHLVIA 132
L E L + AEL + + +T ++K L + A L L +
Sbjct: 177 KIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEG 236

Query: 133 LNNEQGSLKQERAKLQEEHGFLEKRCTNLEKENQRLTDKLKKLESTQKNLENTNNQLRQS 192
N + + L+ E LE R LEK + + + K LE L
Sbjct: 237 AMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAE 296

Query: 193 LENSNDQ----------LLQAKEKIAEENTELEREIARLKSLETMEEKSKLDLHNRRLAS 242
+ Q L + + E +LE E +L+ + E S+ L AS
Sbjct: 297 KADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDAS 356

Query: 243 --ANQDLKRQNRKLEEENIALKERAYGLNEQL 272
A + L+ +++KLEE+N + L L
Sbjct: 357 REAKKQLEAEHQKLEEQNKISEASRQSLRRDL 388



Score = 30.4 bits (68), Expect = 0.008
Identities = 38/217 (17%), Positives = 72/217 (33%), Gaps = 4/217 (1%)

Query: 4 LIEKWFGFYQIREELEARIGELEDENAELFTTKEKLTKENTELAYKNNKL----FKENEK 59
L + + E + L K L EL ++ K
Sbjct: 153 LAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAK 212

Query: 60 ISGLENANDQLWQAKDKLTKENTELTHKNAELLRERDNLAKENTELASKTAALTEKTAEL 119
I LE L K L K + + + L E L ++ A L +
Sbjct: 213 IKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGA 272

Query: 120 KTENDKLNHLVIALNNEQGSLKQERAKLQEEHGFLEKRCTNLEKENQRLTDKLKKLESTQ 179
+ + + L E+ +L+ E+A L+ + L +L ++ + K+LE+
Sbjct: 273 MNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEH 332

Query: 180 KNLENTNNQLRQSLENSNDQLLQAKEKIAEENTELER 216
+ LE N S ++ L ++E + E ++
Sbjct: 333 QKLEEQNKISEASRQSLRRDLDASREAKKQLEAEHQK 369



Score = 30.0 bits (67), Expect = 0.010
Identities = 44/221 (19%), Positives = 83/221 (37%), Gaps = 3/221 (1%)

Query: 15 REELEARIGELEDENAELFTTKEKLTKENTELAYKNNKLFKENEKISGLENANDQLWQAK 74
A +++ AE + L N ++ KI LE L +
Sbjct: 203 MNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQ 262

Query: 75 DKLTKENTELTHKNAELLRERDNLAKENTELASKTAALTEKTAELKTENDKLNHLVIALN 134
+L K + + + L E L ++ A L ++ L L + A
Sbjct: 263 AELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASR 322

Query: 135 NEQGSLKQERAKLQEEHGFLEKRCTNLEKENQRLTDKLKKLESTQKNLENTNNQLRQSLE 194
+ L+ E KL+E++ E +L ++ + K+LE+ + LE N S +
Sbjct: 323 EAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQ 382

Query: 195 NSNDQL---LQAKEKIAEENTELEREIARLKSLETMEEKSK 232
+ L +AK+++ + E ++A L+ L E+SK
Sbjct: 383 SLRRDLDASREAKKQVEKALEEANSKLAALEKLNKELEESK 423


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0068UREASE10450.0 Urea amidohydrolase (urease) protein signature.
		>UREASE#Urea amidohydrolase (urease) protein signature.

Length = 570

Score = 1045 bits (2703), Expect = 0.0
Identities = 354/569 (62%), Positives = 443/569 (77%), Gaps = 4/569 (0%)

Query: 3 KISRKEYVSMYGPTTGDKVRLGDTDLIAEVEHDYTIYGEELKFGGGKTLREGMSQSN-NP 61
++SR Y +M+GPT GDKVRL DT+L EVE D+T +GEE+KFGGGK +R+GM QS
Sbjct: 4 RMSRAAYANMFGPTVGDKVRLADTELFIEVEKDFTTHGEEVKFGGGKVIRDGMGQSQVTR 63

Query: 62 SKEELDLIITNALIVDYTGIYKADIGIKDGKIAGIGKGGNKDMQDGVKNNLSVGPATEAL 121
+D +ITNALI+D+ GI KADIG+KDG+IA IGK GN DMQ GV + VGP TE +
Sbjct: 64 EGGAVDTVITNALILDHWGIVKADIGLKDGRIAAIGKAGNPDMQPGV--TIIVGPGTEVI 121

Query: 122 AGEGLIVTAGGIDTHIHFISPQQIPTAFASGVTTMIGGGTGPADGTNATTITPGRRNLKW 181
AGEG IVTAGG+D+HIHFI PQQI A SG+T M+GGGTGPA GT ATT TPG ++
Sbjct: 122 AGEGKIVTAGGMDSHIHFICPQQIEEALMSGLTCMLGGGTGPAHGTLATTCTPGPWHIAR 181

Query: 182 MLRAAEEYSMNLGFLAKGNASNDASLADQIEAGAIGFKIHEDWGTTPSAINHALDVADKY 241
M+ AA+ + MNL F KGNAS +L + + GA K+HEDWGTTP+AI+ L VAD+Y
Sbjct: 182 MIEAADAFPMNLAFAGKGNASLPGALVEMVLGGATSLKLHEDWGTTPAAIDCCLSVADEY 241

Query: 242 DVQVAIHTDTLNEAGCVEDTMAAIAGRTMHTFHTEGAGGGHAPDIIKVAGEHNILPASTN 301
DVQV IHTDTLNE+G VEDT+AAI GRT+H +HTEGAGGGHAPDII++ G+ N++P+STN
Sbjct: 242 DVQVMIHTDTLNESGFVEDTIAAIKGRTIHAYHTEGAGGGHAPDIIRICGQPNVIPSSTN 301

Query: 302 PTIPFTVNTEAEHMDMLMVCHHLDKSIKEDVQFADSRIRPQTIAAEDTLHDMGIFSITSS 361
PT P+TVNT AEH+DMLMVCHHL +I ED+ FA+SRIR +TIAAED LHD+G FSI SS
Sbjct: 302 PTRPYTVNTLAEHLDMLMVCHHLSPTIPEDIAFAESRIRKETIAAEDILHDIGAFSIISS 361

Query: 362 DSQAMGRVGEVITRTWQTADKNKKEFGRLKEEKGDNDNFRIKRYLSKYTINPAIAHGISE 421
DSQAMGRVGEV RTWQTADK K++ GRLKEE GDNDNFR+KRY++KYTINPAIAHG+S
Sbjct: 362 DSQAMGRVGEVAIRTWQTADKMKRQRGRLKEETGDNDNFRVKRYIAKYTINPAIAHGLSH 421

Query: 422 YVGSVEVGKVADLVLWSPAFFGVKPNMIIKGGFIALSQMGDANASIPTPQPVYYREMFAH 481
+GS+EVGK ADLVLW+PAFFGVKP+M++ GG IA + MGD NASIPTPQPV+YR MF
Sbjct: 422 EIGSLEVGKRADLVLWNPAFFGVKPDMVLLGGTIAAAPMGDPNASIPTPQPVHYRPMFGA 481

Query: 482 HGKAKYDANITFVSQAAYDKGIKEELGLERQVLPVKNCR-NITKKDMQFNDTTAHIEVNP 540
+G+++ ++++TFVSQA+ D G+ LG+ ++++ V+N R I K M N T HIEV+P
Sbjct: 482 YGRSRTNSSVTFVSQASLDAGLAGRLGVAKELVAVQNTRGGIGKASMIHNSLTPHIEVDP 541

Query: 541 ETYHVFVDGKEVTSKPANKVSLAQLFSIF 569
ETY V DG+ +T +PA + +AQ + +F
Sbjct: 542 ETYEVRADGELLTCEPATVLPMAQRYFLF 570


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0077TACYTOLYSIN300.040 Bacterial thiol-activated pore-forming cytolysin sig...
		>TACYTOLYSIN#Bacterial thiol-activated pore-forming cytolysin

signature.
Length = 574

Score = 29.6 bits (66), Expect = 0.040
Identities = 17/46 (36%), Positives = 24/46 (52%), Gaps = 3/46 (6%)

Query: 499 NTDTGNTDTGNTDTGNTDDMSNMNNG---NDDAGNANDDMGNSNDM 541
N D+ +T NT+T T++ + + AG DDM NSNDM
Sbjct: 33 NADSNKQNTANTETTTTNEQPKPESSELTTEKAGQKMDDMLNSNDM 78


2HELPY_0101HELPY_0108Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_01011133.364690Methyl-accepting chemotaxis protein tlpB;
HELPY_01022153.6283402',3'-cyclic-nucleotide 2'-phosphodiesterase
HELPY_0104-2114.520028S-ribosylhomocysteine lyase (Autoinducer-2
HELPY_0105-2124.040448Cystathionine gamma-synthase (CGS)
HELPY_0106-1132.317854Cysteine synthase (O-acetylserine sulfhydrylase)
HELPY_01072161.402909Chaperone protein dnaK (Heat shock protein 70)
HELPY_01082151.216189Protein GrpE (HSP-70 cofactor)
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0104LUXSPROTEIN2262e-79 Bacterial autoinducer-2 (AI-2) production protein Lu...
		>LUXSPROTEIN#Bacterial autoinducer-2 (AI-2) production protein LuxS

signature.
Length = 171

Score = 226 bits (578), Expect = 2e-79
Identities = 60/145 (41%), Positives = 91/145 (62%), Gaps = 7/145 (4%)

Query: 5 VESFNLDHTKVKAPYVRIADRKKGANGDVIVKYDVRFKQPNKDHMDMPSLHSLEHLVAEI 64
++SF +DHT++ AP VR+A + GD I +D+RF PNKD + +H+LEHL A
Sbjct: 3 LDSFTVDHTRMNAPAVRVAKTMQTPKGDTITVFDLRFTAPNKDILSEKGIHTLEHLYAGF 62

Query: 65 IRNHAN----YVVDWSPMGCQTGFYLTVLNHDNYTEVLEVLEKTMQDVLKA---TEVPAS 117
+RNH N ++D SPMGC+TGFY++++ + +V + M+DVLK ++P
Sbjct: 63 MRNHLNGDSVEIIDISPMGCRTGFYMSLIGTPSEQQVADAWIAAMEDVLKVENQNKIPEL 122

Query: 118 NEKQCGWAANHTLEGAKNLARAFLD 142
NE QCG AA H+L+ AK +A+ L+
Sbjct: 123 NEYQCGTAAMHSLDEAKQIAKNILE 147


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0109SHAPEPROTEIN1487e-42 Bacterial cell shape determinant MreB/Mbl protein s...
		>SHAPEPROTEIN#Bacterial cell shape determinant MreB/Mbl protein

signature.
Length = 347

Score = 148 bits (376), Expect = 7e-42
Identities = 77/384 (20%), Positives = 141/384 (36%), Gaps = 86/384 (22%)

Query: 5 IGIDLGTTNSAMAVYEG----NEAKIIA-NKEGKNTTPSIVAFTDKGEILVGESAKRQAV 59
+ IDLGT N+ + V NE ++A ++ + S+ A VG AK+
Sbjct: 13 LSIDLGTANTLIYVKGQGIVLNEPSVVAIRQDRAGSPKSVAA--------VGHDAKQMLG 64

Query: 60 TNPEKTIYSIKRIMGLMFNEDKAKEAEKRLPYKIVDRNGACAIEISGKVYTPQEISAKIL 119
P I +I+ + ++G A + +++ +
Sbjct: 65 RTPGN-IAAIRPM-----------------------KDGVIA-----DFFVTEKMLQHFI 95

Query: 120 MKLKEDAESYLGESVTEAVITVPAYFNDSQRKATKEAGTIAGLNVLRIINEPTSAALAYG 179
++ ++ ++ VP +R+A +E+ AG + +I EP +AA+ G
Sbjct: 96 KQVHSNS---FMRPSPRVLVCVPVGATQVERRAIRESAQGAGAREVFLIEEPMAAAIGAG 152

Query: 180 LDKKESEKIMVYDLGGGTFDVTVLETGDNVVEVLATGGDAFLGGDDFDNRVIDFLAAEFK 239
L E+ MV D+GGGT +V V+ V +GGD FD +I+++ +
Sbjct: 153 LPVSEATGSMVVDIGGGTTEVAVISLNGVV-----YSSSVRIGGDRFDEAIINYVRRNYG 207

Query: 240 NETGIEIKNDVMALQRLKEAAENAKKELSSAM----ETEINLPFITADATGPKHLVKKLT 295
+ G + AE K E+ SA EI + P+ +
Sbjct: 208 SLIG-------------EATAERIKHEIGSAYPGDEVREIEVRGRNLAEGVPRGFTLN-S 253

Query: 296 RAKFESLTEDL----------MEETISKIESVIKDAGLTKNEISEVVMVGGSTRIPKVQE 345
E+L E L +E+ ++ S I + G +V+ GG + +
Sbjct: 254 NEILEALQEPLTGIVSAVMVALEQCPPELASDISERG--------MVLTGGGALLRNLDR 305

Query: 346 RVKAFINKDLNKSVNPDEVVAVGA 369
+ + + +P VA G
Sbjct: 306 LLMEETGIPVVVAEDPLTCVARGG 329


3HELPY_0189HELPY_0208Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_01892160.484695Conserved hypothetical protein
HELPY_01901132.664386Conserved hypothetical protein; putative
HELPY_01910112.682381Putative phospholipase D
HELPY_0192-1102.044286Fumarate reductase, iron-sulfur subunit
HELPY_0193-1102.058632Fumarate reductase, flavoprotein subunit
HELPY_0194-1122.970430Fumarate reductase, transmembrane subunit;
HELPY_0195-1113.141843Triosephosphate isomerase (TIM)
HELPY_0196-1141.594488Putative enoyl-(acyl-carrier-protein) reductase
HELPY_0197-1161.620333UDP-3-O-[3-hydroxymyristoyl] glucosamine
HELPY_0198-1162.697190S-adenosylmethionine synthetase (Methionine
HELPY_0199-1163.065043Nucleoside diphosphate kinase (NDK) (NDP kinase)
HELPY_0200-2173.180312Conserved hypothetical protein
HELPY_0201-2182.14642250S ribosomal subunit protein L32
HELPY_0202-2191.603414Fatty acid/phospholipid synthesis protein PlsX
HELPY_0203-212-0.0793073-oxoacyl-[acyl-carrier-protein] synthase III
HELPY_0204013-3.220208Conserved hypothetical protein
HELPY_0206012-4.103718Conserved hypothetical protein; putative signal
HELPY_0208-110-3.290209ATP-binding protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0189IGASERPTASE310.004 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 31.2 bits (70), Expect = 0.004
Identities = 24/139 (17%), Positives = 50/139 (35%), Gaps = 4/139 (2%)

Query: 55 LQTDSGMQKIGNTKDEKKDDEFESLNLDP--SKQEDKLDKVADNVKKQENDAFNMPVQTD 112
L+ +G + N + EK++ ++ N+ + Q D ++N + D PV
Sbjct: 971 LRNVNGRYDLYNPEVEKRNQTVDTTNITTPNNIQADVPSVPSNNEEIARVD--EAPVPPP 1028

Query: 113 QTQTEMKTTEETKEAQKELKVVEHTSAQKESQAVVKKETPHKKPKATPKDKEAHKDKDKH 172
T +TTE E K+ + Q ++ + K+ K+ K + +
Sbjct: 1029 APATPSETTETVAENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQS 1088

Query: 173 AVKELKVKKEAHKEVPKKA 191
+ + + KE
Sbjct: 1089 GSETKETQTTETKETATVE 1107



Score = 31.2 bits (70), Expect = 0.006
Identities = 24/121 (19%), Positives = 44/121 (36%), Gaps = 6/121 (4%)

Query: 79 LNLDPSKQ----EDKLDKVADNVKKQENDAFNMPVQTDQTQTEMKTTEETKEAQKELKVV 134
PS+ + + + V+K E DA Q + E K+ K + +V
Sbjct: 1029 APATPSETTETVAENSKQESKTVEKNEQDATETTAQNREVAKEAKS--NVKANTQTNEVA 1086

Query: 135 EHTSAQKESQAVVKKETPHKKPKATPKDKEAHKDKDKHAVKELKVKKEAHKEVPKKANSK 194
+ S KE+Q KET + + K + + ++ K+E + V +A
Sbjct: 1087 QSGSETKETQTTETKETATVEKEEKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEPA 1146

Query: 195 T 195

Sbjct: 1147 R 1147



Score = 30.8 bits (69), Expect = 0.006
Identities = 27/150 (18%), Positives = 53/150 (35%), Gaps = 10/150 (6%)

Query: 50 PKETFLQTDSGMQKIGNTKDEKKDDEFESLNLDPSKQEDKLDKVADNVKKQENDAFNMPV 109
P ET ++ T ++ + D E+ + ++ V N Q N+
Sbjct: 1033 PSETTETVAENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVKAN--TQTNEVAQSGS 1090

Query: 110 QTDQTQTEMKTTEETKEAQKELKVVEHTSAQKESQAVVKKETPHKKPKATPKDKEAHKDK 169
+T +TQT T E +++ KV + + + V + K+ ++ +A +
Sbjct: 1091 ETKETQTTETKETATVEKEEKAKV---ETEKTQEVPKVTSQVSPKQEQSETVQPQAEPAR 1147

Query: 170 DKHAVKELKVK-----KEAHKEVPKKANSK 194
+ +K A E P K S
Sbjct: 1148 ENDPTVNIKEPQSQTNTTADTEQPAKETSS 1177


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0198DHBDHDRGNASE614e-13 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase sig...
		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

signature.
Length = 261

Score = 61.2 bits (148), Expect = 4e-13
Identities = 61/263 (23%), Positives = 109/263 (41%), Gaps = 29/263 (11%)

Query: 4 LKGKKGLIVGVANNKSIAYGIAQSCFNQGATL-AFTYLNESLEKRVRPIAQELNSQYVYE 62
++GK I G A + I +A++ +QGA + A Y E LEK V + E +
Sbjct: 6 IEGKIAFITGAA--QGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFP 63

Query: 63 LDVSKEEHFKPLYNSVKKDLGSLDFIVHSVAF--------APKEALEGSLLETSKSAFNT 114
DV + +++++G +D +V+ E E + S FN
Sbjct: 64 ADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNA 123

Query: 115 AMEISVYSLIELTNTLKPLLNNGASVLTLSYLGSTKYMAHYNVMGLAKAALESAVRYLAV 174
+ +S Y + + ++ + +N A V S MA Y +KAA + L +
Sbjct: 124 SRSVSKYMMDRRSGSIVTVGSNPAGVPRTS-------MAAY---ASSKAAAVMFTKCLGL 173

Query: 175 DLGKHNIRVNALSAGPIRT-----LASSGIADFRMILKWNE---INAPLRKNVSLEEVGN 226
+L ++NIR N +S G T L + ++I E PL+K ++ +
Sbjct: 174 ELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIAD 233

Query: 227 AGMYLLSSLSSGVSGEVHFVDAG 249
A ++L+S + ++ VD G
Sbjct: 234 AVLFLVSGQAGHITMHNLCVDGG 256


4HELPY_0302HELPY_0344Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_03021143.48901650S ribosomal subunit protein L21
HELPY_03031143.43377050S ribosomal subunit protein L27
HELPY_03041153.548074ABC-type transport system, periplasmic binding
HELPY_03051143.860486ABC-type transport system, permease; putative
HELPY_03060123.134148ABC-type transport system, permease; putative
HELPY_0308-2132.994997ABC-type transport system, ATP-binding protein;
HELPY_0309-2132.634580ABC-type transport system, ATP binding protein;
HELPY_0310-1122.126679Putative GTP-binding protein, GTP1/Obg family
HELPY_0311-1121.457346Conserved hypothetical protein; putative signal
HELPY_03120171.924811Conserved hypothetical protein; putative signal
HELPY_03130182.262124Glutamate-1-semialdehyde 2,1-aminomutase (GSA)
HELPY_03143181.622568Conserved hypothetical protein; putative signal
HELPY_03152171.613352Conserved hypothetical protein; putative
HELPY_03162161.920616Putative N-carbomoyl-D-amino acid
HELPY_03170120.899961Putative NodB-like polysaccharide deacetylase
HELPY_03180120.143106Conserved hypothetical protein
HELPY_0319014-0.101220Putative cobalamin syntheis protein, P47K
HELPY_0320116-1.013050Putative nitrite extrusion protein, major
HELPY_0321216-1.465851Conserved hypothetical protein
HELPY_0322116-1.601778Arginyl-tRNA synthetase (Arginine--tRNA ligase)
HELPY_0323115-0.901241Sec-independent protein translocase protein
HELPY_0324015-1.182347Guanylate kinase (GMP kinase)
HELPY_0325014-1.495109Conserved hypothetical protein; poly E-rich
HELPY_0326-114-2.059112Putative phospholipase D family protein;
HELPY_0327114-1.914075Outer membrane protein HorC; putative signal
HELPY_0328216-2.245457Flagellar L-ring protein precursor (Basal body
HELPY_0329215-2.095984Putative flagellar biosynthesis protein
HELPY_0330211-1.268133Tetraacyldisaccharide 4'-kinase (Lipid A
HELPY_0331211-0.889976NH(3)-dependent NAD(+) synthetase
HELPY_03321140.308107*Ketol-acid reductoisomerase (Acetohydroxy-acid
HELPY_03331150.885024Cell division inhibitor MinD
HELPY_03340150.778243Cell division topological specificity factor
HELPY_0335-114-0.277701DNA processing chain A (DprA)
HELPY_0336014-1.735110Putative holliday junction resolvase
HELPY_0337-114-1.434712Cysteine-rich protein H
HELPY_0338016-2.300513Conserved hypothetical protein
HELPY_0339119-3.106611Conserved hypothetical protein
HELPY_0340221-2.331883Conserved hypothetical protein; putative
HELPY_0341222-0.503775Conserved hypothetical protein; putative
HELPY_03425290.183515Pseudouridine synthase (RNA-uridine isomerase)
HELPY_0343730-0.045654Single-stranded-DNA-specific exonuclease RecJ
HELPY_0344425-0.359493CTP synthase (UTP--ammonia ligase) (CTP
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0320TCRTETB320.005 Tetracycline resistance protein TetB signature.
		>TCRTETB#Tetracycline resistance protein TetB signature.

Length = 458

Score = 31.8 bits (72), Expect = 0.005
Identities = 37/207 (17%), Positives = 83/207 (40%), Gaps = 1/207 (0%)

Query: 23 VLIPLLILSGSLTPHQSFQLGIAVLMGYVFGSFLIQFLSPLMSLESIAKISFGLIALSFL 82
V +P + + P + + A ++ + G+ + LS + ++ + + +
Sbjct: 35 VSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSV 94

Query: 83 VCYFDSIPFFWLWIWRFIAGVASSALMILVAPLSLPYVKEHKKALVGGLIFSAVGIGSVF 142
+ + F L + RFI G ++A LV + Y+ + + GLI S V +G
Sbjct: 95 IGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGV 154

Query: 143 SGFVLPWISSYNIKWAWIFLGGSCLIAFILSLVGLKTRSLRKKSVKKEESAFKIPFHLWL 202
+ I+ Y I W+++ L I + L+ L + +R K + + +
Sbjct: 155 GPAIGGMIAHY-IHWSYLLLIPMITIITVPFLMKLLKKEVRIKGHFDIKGIILMSVGIVF 213

Query: 203 LLISCALNAIGFLPHTLFWVDYLIRHL 229
++ +I FL ++ ++H+
Sbjct: 214 FMLFTTSYSISFLIVSVLSFLIFVKHI 240


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0324PF05272290.011 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 29.3 bits (65), Expect = 0.011
Identities = 9/18 (50%), Positives = 11/18 (61%)

Query: 8 LILSGPSGAGKSTLTKYL 25
++L G G GKSTL L
Sbjct: 599 VVLEGTGGIGKSTLINTL 616


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0325IGASERPTASE648e-13 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 63.9 bits (155), Expect = 8e-13
Identities = 51/275 (18%), Positives = 88/275 (32%), Gaps = 25/275 (9%)

Query: 148 EALAKEEPNNEEQLLPTLDAQEEKEEVKETPQKEEKPKDDETQESETPKDEEVSKELETQ 207
E +A+ + P + E E V E ++E K + Q++ + +
Sbjct: 1015 EEIARVDEAPVPPPAPATPS-ETTETVAENSKQESKTVEKNEQDATETT-------AQNR 1066

Query: 208 ENKEEKQEETQDSPSAQELEAMQELVKEIQENSNGQEDKKETQESAEISQDKEIQEVVTE 267
E +E + + + E+ KE Q + KET + + K E E
Sbjct: 1067 EVAKEAKSNVKANTQTNEVAQSGSETKETQT-----TETKETATVEKEEKAKVETEKTQE 1121

Query: 268 KTQVQELEVPK----EKTQESAEALQE----TQAHELEKQENTETPQEKEKQEIAETPQE 319
+V PK E Q AE +E E + Q NT E+ +E + ++
Sbjct: 1122 VPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQTNTTADTEQPAKETSSNVEQ 1181

Query: 320 --KEKQEIAETPQEKETPQEETQETQEVVTEQTQEDHYENIEDIPEPVMAKAMGEELPFL 377
E + E P+ T T + E + V + E
Sbjct: 1182 PVTESTTVNTGNSVVENPENTTPATTQ--PTVNSESSNKPKNRHRRSVRSVPHNVEPATT 1239

Query: 378 NESVAETPNSENATETPQEKEESDKTSSPLELRLN 412
+ + T + T T SD + + LN
Sbjct: 1240 SSNDRSTVALCDLTSTNTNAVLSDARAKAQFVALN 1274



Score = 60.8 bits (147), Expect = 6e-12
Identities = 47/264 (17%), Positives = 97/264 (36%), Gaps = 15/264 (5%)

Query: 178 PQKEEKPKDDETQESETPKDEEVSKELETQENKE-EKQEETQDSPSAQELEAMQELVKEI 236
P+ E++ + +T TP + + N+E + +E P A +
Sbjct: 983 PEVEKRNQTVDTTNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVAE 1042

Query: 237 QENSNGQEDKKETQESAEISQDKEIQEVVTEKTQVQELEVPKEKTQESAEALQETQAHEL 296
+ +K Q++ E + +EV E + + +S +ETQ E
Sbjct: 1043 NSKQESKTVEKNEQDATETTAQN--REVAKEAKSNVKANTQTNEVAQSGSETKETQTTE- 1099

Query: 297 EKQENTETPQEKEKQEIAETPQEKEKQEIAETPQEKETPQEETQETQEVVTEQTQEDHYE 356
T+ EK+E A+ E + QE+ + + QE+++ Q + D
Sbjct: 1100 -----TKETATVEKEEKAKVETE-KTQEVPKVTSQVSPKQEQSETVQPQAEPARENDPTV 1153

Query: 357 NIEDIPEPVMAKAMGEELPFLNESVAETPNSENATET-----PQEKEESDKTSSPLELRL 411
NI++ A E+ S E P +E+ T + E + ++ +
Sbjct: 1154 NIKEPQSQTNTTADTEQPAKETSSNVEQPVTESTTVNTGNSVVENPENTTPATTQPTVNS 1213

Query: 412 NLQDLLKSLNQESLKSLLENKTLS 435
+ K+ ++ S++S+ N +
Sbjct: 1214 ESSNKPKNRHRRSVRSVPHNVEPA 1237



Score = 54.3 bits (130), Expect = 7e-10
Identities = 35/253 (13%), Positives = 77/253 (30%), Gaps = 6/253 (2%)

Query: 99 KPFLPTEMLKVLQKKLGSDMSELEPSQN--LDPTQEVLETNWDELENLGDLEALAKEEPN 156
++ + S+ E+ + P + E + E N
Sbjct: 995 TNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVAENSKQESKTVEKN 1054

Query: 157 NEEQLLPTLDAQEEKEEVKETPQKEEKPKDDETQESETPKDEEVSKELETQENKEEKQ-- 214
++ T +E +E K + + + SET + + + KEEK
Sbjct: 1055 EQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETKETATVEKEEKAKV 1114

Query: 215 --EETQDSPSAQELEAMQELVKEIQENSNGQEDKKETQESAEISQDKEIQEVVTEKTQVQ 272
E+TQ+ P + ++ E + + + + + Q + TE+ +
Sbjct: 1115 ETEKTQEVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQTNTTADTEQPAKE 1174

Query: 273 ELEVPKEKTQESAEALQETQAHELEKQENTETPQEKEKQEIAETPQEKEKQEIAETPQEK 332
++ ES E + T Q E + P+ + ++ + P
Sbjct: 1175 TSSNVEQPVTESTTVNTGNSVVENPENTTPATTQPTVNSESSNKPKNRHRRSVRSVPHNV 1234

Query: 333 ETPQEETQETQEV 345
E + + V
Sbjct: 1235 EPATTSSNDRSTV 1247


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0328FLGLRINGFLGH1913e-63 Flagellar L-ring protein signature.
		>FLGLRINGFLGH#Flagellar L-ring protein signature.

Length = 232

Score = 191 bits (486), Expect = 3e-63
Identities = 51/172 (29%), Positives = 84/172 (48%), Gaps = 18/172 (10%)

Query: 56 GERPLFADRRAMKPNDLITIIVSEKASANYSSS----KDYKSASGGNSTPPRLTYNGLDE 111
G +PLF DRR D +TI++ E SA+ SSS +D K+ G ++ P L GL
Sbjct: 61 GYQPLFEDRRPRNIGDTLTIVLQENVSASKSSSANASRDGKTNFGFDTVPRYL--QGLFG 118

Query: 112 RKKQEAQYLDDKNNYNFTKSSNNTNFKGGGSQKKSEDLEIVLSARIIKVLENGNYFIYGN 171
+ + + S F G G S L+ + +VL NGN + G
Sbjct: 119 NARADVEA------------SGGNTFNGKGGANASNTFSGTLTVTVDQVLVNGNLHVVGE 166

Query: 172 KEVLVDGEKQILKVSGVIRPYDIERNNTIQSKFLADAKIEYTNLGHLSDSNK 223
K++ ++ + ++ SGV+ P I +NT+ S +ADA+IEY G+++++
Sbjct: 167 KQIAINQGTEFIRFSGVVNPRTISGSNTVPSTQVADARIEYVGNGYINEAQN 218


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0331SACTRNSFRASE280.020 Streptothricin acetyltransferase signature.
		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

Length = 173

Score = 27.6 bits (61), Expect = 0.020
Identities = 14/49 (28%), Positives = 21/49 (42%), Gaps = 3/49 (6%)

Query: 102 KGETILKALECIAFE---EFQLHSLHLEVMENNFKAIAFYEKNHYELEG 147
+ + + AL A E E L LE + N A FY K+H+ +
Sbjct: 102 RKKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGA 150


5HELPY_0390HELPY_0396Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_0390210-0.789202Sec-independent protein translocase protein
HELPY_0391212-1.504382Holliday junction ATP-dependent DNA helicase
HELPY_0392215-2.5701383-methyl-2-oxobutanoate hydroxymethyltransferase
HELPY_0393217-2.493691Conserved hypothetical protein; putative signal
HELPY_0394216-2.626516Conserved hypothetical protein; putative signal
HELPY_0395216-1.548204Conserved hypothetical protein
HELPY_0396215-1.279926Conserved hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0390TATBPROTEIN1302e-41 Bacterial sec-independent translocation TatB protein...
		>TATBPROTEIN#Bacterial sec-independent translocation TatB protein

signature.
Length = 171

Score = 130 bits (328), Expect = 2e-41
Identities = 30/164 (18%), Positives = 69/164 (42%), Gaps = 16/164 (9%)

Query: 1 MFGMGFFEILVVLVVAIIFLGPEKFPQAVVDVVKFFRAVKKTLNDAKDTLDKEINIEEIK 60
MF +GF E+L+V ++ ++ LGP++ P AV V + RA++ ++ L +E+ ++E +
Sbjct: 1 MFDIGFSELLLVFIIGLVVLGPQRLPVAVKTVAGWIRALRSLATTVQNELTQELKLQEFQ 60

Query: 61 KETLEYQKLFENKVESLKGVKIEELEDAKITAENEIKSIQDLMQDYQQSLENNTPPNH-- 118
+ +K + +L +++ + AE+ +S + + S E +T N
Sbjct: 61 DSLKKVEKA---SLTNLTPELKASMDELRQAAESMKRSYVANDPE-KASDEAHTIHNPVV 116

Query: 119 ----------PNGEVSNEEISSDESLKEVQLATDNNAKEHDKEK 152
+ S ++ + A + + +
Sbjct: 117 KDNEAAHEGVTPAAAQTQASSPEQKPETTPEPVVKPAADAEPKT 160


6HELPY_0457HELPY_0473Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_0457013-3.651551ABC-type transport system, ATP-binding protein;
HELPY_0458012-3.869229Glutamyl-tRNA synthetase (Glutamate--tRNA
HELPY_0459010-2.381881Outer membrane protein HopJ; putative signal
HELPY_0460-111-2.192613M.HpyAVII, type II adenine specific
HELPY_0461-112-3.022475Putative non-functional type II restriction
HELPY_0462-111-2.547755GTP-binding elongation factor protein, TypA
HELPY_04632110.173943M. Hpy99XI, type II cytosine specific DNA
HELPY_04644140.962718Putative non-functional type II restriction
HELPY_0465416-0.548564Putative catalase; putative signal peptide
HELPY_0466517-0.430421Outer membrane protein HofC; putative signal
HELPY_04686190.409161Outer membrane protein HofD; putative signal
HELPY_04696190.048684Conserved hypothetical protein
HELPY_0470317-1.285032Hypothetical protein
HELPY_04711180.700096Conserved hypothetical protein
HELPY_04722142.403942Crossover junction endodeoxyribonuclease RuvC
HELPY_04732132.133154Iron-regulated outer membrane protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0459PF05272310.004 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 31.2 bits (70), Expect = 0.004
Identities = 12/32 (37%), Positives = 18/32 (56%)

Query: 30 VVALLGESGAGKSTILRILAGLEAVSSGYIEV 61
V L G G GKST++ L GL+ S + ++
Sbjct: 598 SVVLEGTGGIGKSTLINTLVGLDFFSDTHFDI 629


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0464TCRTETOQM1963e-57 Tetracycline resistance protein TetO/TetQ/TetM family ...
		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

signature.
Length = 639

Score = 196 bits (501), Expect = 3e-57
Identities = 115/461 (24%), Positives = 190/461 (41%), Gaps = 67/461 (14%)

Query: 3 NIRNIAVIAHVDHGKTTLVDGLLSQSGTFSEREKVDE--RVMDSNDLERERGITILSKNT 60
I NI V+AHVD GKTTL + LL SG +E VD+ D+ LER+RGITI + T
Sbjct: 2 KIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGIT 61

Query: 61 AIYYKDTKINIIDTPGHADFGGEVERVLKMVDGVLLLVDAQEGVMPQTKFVVKKALSFGI 120
+ +++TK+NIIDTPGH DF EV R L ++DG +LL+ A++GV QT+ + GI
Sbjct: 62 SFQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALRKMGI 121

Query: 121 CPIVVVNKIDKPAAEPDRVVDEVFDLF---------VAMGASDKQLDFPV-----VYAAA 166
I +NKID+ + V ++ + V + + +F
Sbjct: 122 PTIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVELYPNMCVTNFTESEQWDTVIEG 181

Query: 167 RDGYAMKSLDDE----------------------------KKNL--EPLFETILEHVPSP 196
D K + + K N+ + L E I S
Sbjct: 182 NDDLLEKYMSGKSLEALELEQEESIRFHNCSLFPVYHGSAKNNIGIDNLIEVITNKFYSS 241

Query: 197 SGSVDEPLQMQIFTLDYDNYVGKIGIARVFNGSVKKNESVLLMKSDGSKENGRITKLIGF 256
+ L ++F ++Y ++ R+++G + +SV + KE +IT++
Sbjct: 242 THRGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLHLRDSVRI----SEKEKIKITEMYTS 297

Query: 257 LGLARTEIENAYAGDIVAIAG--FNAMDV-GDSVVDPANPMPLDPMHLEEPTMSVYFAVN 313
+ +I+ AY+G+IV + V GD+ + P +P P + +
Sbjct: 298 INGELCKIDKAYSGEIVILQNEFLKLNSVLGDTKLLPQRERIENP----LPLLQTTVEPS 353

Query: 314 DSPLAGLEGKHVTANKLKDRLLKEMQTNIAMKCEEMGEGKFKVSGRGELQITILAENLRR 373
+ + D LL+ + + +S G++Q+ + L+
Sbjct: 354 KPQQREMLLDALLEISDSDPLLRYYVDSAT--------HEIILSFLGKVQMEVTCALLQE 405

Query: 374 E-GFEFSISRPEVIIKEENGVKCEPFEHLVIDTPQDFSGAI 413
+ E I P VI E K E H+ + P F +I
Sbjct: 406 KYHVEIEIKEPTVIYMERPLKKAEYTIHIEVP-PNPFWASI 445



Score = 41.8 bits (98), Expect = 8e-06
Identities = 20/80 (25%), Positives = 30/80 (37%), Gaps = 1/80 (1%)

Query: 396 EPFEHLVIDTPQDFSGAIIERLGKRKAEMKAMNPMSDGYTRLEFEIPARGLIGYRSEFLT 455
EP+ I PQ++ K A + + + L EIPAR + YRS+
Sbjct: 537 EPYLSFKIYAPQEYLSRAYTDAPKYCANIVDTQ-LKNNEVILSGEIPARCIQEYRSDLTF 595

Query: 456 DTKGEGVMNHSFLEFRPFSG 475
T G V + +G
Sbjct: 596 FTNGRSVCLTELKGYHVTTG 615


7HELPY_0593HELPY_0600Y        NNGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_0593-115-3.559585Conserved hypothetical protein
HELPY_0594015-3.280331Putative signal recognition particule receptor
HELPY_0595421-2.050065Conserved hypothetical protein; putative signal
HELPY_0596424-1.337615Conserved hypothetical protein
HELPY_0597422-0.110417Conserved hypothetical protein
HELPY_0598319-0.572965Multidrug efflux protein MatE; putative membrane
HELPY_06002121.001080Conserved hypothetical protein; putative
8HELPY_0632HELPY_0645Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_0632212-2.671017Putative outer membrane protein; putative signal
HELPY_0633213-3.233536Outer membrane protein HopP
HELPY_0634216-4.315398Anaerobic C4-dicarboxylate transporter DcuA;
HELPY_0635215-3.481015L-asparaginase (L-asparagine amidohydrolase)
HELPY_0636114-2.214153Hypothetical protein
HELPY_0637013-0.620497Conserved hypothetical protein; putative signal
HELPY_06380120.535454Conserved hypothetical protein
HELPY_06391132.194553Putative L-lysine exporter; putative membrane
HELPY_06402143.009958DNA polymerase III gamma and tau subunits
HELPY_06413143.121791Putative ATPase
HELPY_06422143.260593ABC-type transport system, ATP binding protein
HELPY_06433122.958676RNA polymerase sigma factor-54
HELPY_06441100.941819Conserved hypothetical protein
HELPY_0645212-0.495993Outer membrane protein HomA; putative signal
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0649IGASERPTASE320.011 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 31.6 bits (71), Expect = 0.011
Identities = 32/138 (23%), Positives = 53/138 (38%), Gaps = 13/138 (9%)

Query: 439 SLATDK-DKELLRERFKIVKGIVD----GVFGKGENIKIALKNHLENKSAREETKEIKDF 493
SL + D + + + V G D V + + + N A + +
Sbjct: 956 SLVGNTVDLGAWKYKLRNVNGRYDLYNPEVEKRNQTVDTTNITTPNNIQADVPSVPSNNE 1015

Query: 494 KISSLKEKILPKP-------TTETTAEMKEKETKEKEIQENDTKEVQETQLKEAPTALQE 546
+I+ + E +P P TTET AE ++E+K E E D E + A A
Sbjct: 1016 EIARVDEAPVPPPAPATPSETTETVAENSKQESKTVEKNEQDATETTAQNREVAKEAKSN 1075

Query: 547 FMAN-HSNLIEEIKSEFE 563
AN +N + + SE +
Sbjct: 1076 VKANTQTNEVAQSGSETK 1093


9HELPY_0662HELPY_0689Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_0662310-0.068012Conserved hypothetical protein
HELPY_0663290.339695Putative N-methylhydantoinase
HELPY_0664111-0.174424Conserved hypothetical protein; putative signal
HELPY_0666111-0.222670Short-chain fatty acid transport protein, scFAT
HELPY_0667010-0.078354Succinyl-CoA-transferase subunit B
HELPY_06682111.479732Succinyl-CoA-transferase subunit A
HELPY_06693152.107839Putative acetyl coenzyme A acetyltransferase
HELPY_06704162.505825Conserved hypothetical protein
HELPY_06717184.200390Ferrous iron transport protein B; putative
HELPY_06736163.930431Iron(III) dicitrate transport protein FecA;
HELPY_06743153.636620Flagellar biosynthetic protein FliP
HELPY_06752163.569838Bifunctional protein GlmU
HELPY_06761143.118525Conserved hypothetical protein; putative signal
HELPY_06781132.273379Conserved hypothetical protein
HELPY_06812111.373586Ribonucleoside-diphosphate reductase, alpha
HELPY_06831100.854135Putative oxidoreductase
HELPY_06842110.228915Conserved hypothetical protein; putative
HELPY_06853110.624014Methylated-DNA--protein-cysteine
HELPY_06863110.900907Putative integrase/recombinase
HELPY_06870101.062019Hypothetical protein
HELPY_06882110.811460Aspartate aminotransferase (Transaminase)
HELPY_06892110.201372Outer membrane protein HorF
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0687FLGBIOSNFLIP2763e-96 Escherichia coli: Flagellar biosynthetic protein Fl...
		>FLGBIOSNFLIP#Escherichia coli: Flagellar biosynthetic protein FliP

signature.
Length = 245

Score = 276 bits (707), Expect = 3e-96
Identities = 113/245 (46%), Positives = 161/245 (65%), Gaps = 2/245 (0%)

Query: 1 MRFFIFFILICPLICPLMSADSALPSVNLSLNAPNDPKQLVTTLNVIALLTLLVLAPSLI 60
MR + + L A + LP + S P + + + +T L P+++
Sbjct: 1 MRRLLSVAPVL-LWLITPLAFAQLPGIT-SQPLPGGGQSWSLPVQTLVFITSLTFIPAIL 58

Query: 61 LVMTSFTRLIVVFSFLRTALGTQQTPPTQILVSLSLILTFFIMEPSLKKAYDTGIKPYMD 120
L+MTSFTR+I+VF LR ALGT PP Q+L+ L+L LTFFIM P + K Y +P+ +
Sbjct: 59 LMMTSFTRIIIVFGLLRNALGTPSAPPNQVLLGLALFLTFFIMSPVIDKIYVDAYQPFSE 118

Query: 121 KKISYTEAFEKSALPFKEFMLKNTREKDLALFFRIRNLPNPKTPDEVSLSVLIPAFMISE 180
+KIS EA EK A P +EFML+ TRE DL LF R+ N + P+ V + +L+PA++ SE
Sbjct: 119 EKISMQEALEKGAQPLREFMLRQTREADLGLFARLANTGPLQGPEAVPMRILLPAYVTSE 178

Query: 181 LKTAFQIGFLLYLPFLVIDMVISSILMAMGMMMLPPVMISLPFKILVFILVDGFNLLTEN 240
LKTAFQIGF +++PFL+ID+VI+S+LMA+GMMM+PP I+LPFK+++F+LVDG+ LL +
Sbjct: 179 LKTAFQIGFTIFIPFLIIDLVIASVLMALGMMMVPPATIALPFKLMLFVLVDGWQLLVGS 238

Query: 241 LVASF 245
L SF
Sbjct: 239 LAQSF 243


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0689PF07132347e-05 Harpin protein (HrpN)
		>PF07132#Harpin protein (HrpN)

Length = 356

Score = 33.9 bits (77), Expect = 7e-05
Identities = 19/45 (42%), Positives = 31/45 (68%)

Query: 42 IGGGVGAGMGGAMGGMIGALGGPWGTVFGAGIGGGIGAYSGAEIG 86
+G +G G+GG +GG+ +LGG G + G G+GGG+G+ G+ +G
Sbjct: 61 MGSMMGGGLGGGLGGLGSSLGGLGGGLLGGGLGGGLGSSLGSGLG 105



Score = 33.1 bits (75), Expect = 2e-04
Identities = 18/50 (36%), Positives = 29/50 (58%)

Query: 38 LGKLIGGGVGAGMGGAMGGMIGALGGPWGTVFGAGIGGGIGAYSGAEIGD 87
+G ++GGG+G G+GG + G GG G G G+G +G+ G+ +G
Sbjct: 61 MGSMMGGGLGGGLGGLGSSLGGLGGGLLGGGLGGGLGSSLGSGLGSALGG 110


10HELPY_0787HELPY_0792Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_0787-214-3.353858Conserved hypothetical protein; putative signal
HELPY_0788117-3.048352Conserved hypothetical protein; putative
HELPY_0789218-0.856596Conserved hypothetical protein; putative
HELPY_0790315-0.826698FolD bifunctional protein
HELPY_0791316-1.473694Signal peptidase I (SPase I) (Leader peptidase
HELPY_0792216-1.869713Conserved hypothetical protein; putative
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0797TYPE3IMSPROT290.007 Type III secretion system inner membrane S protein ...
		>TYPE3IMSPROT#Type III secretion system inner membrane S protein

family signature.
Length = 354

Score = 29.3 bits (66), Expect = 0.007
Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 4/64 (6%)

Query: 88 LQSYSVMLFFNLLLLTDILGFLPFSIYHHFMASLIFSALFCSSLFLSNPLLGMIALMALS 147
L Y F L+L+ +LPFS S + + +L PLL + ALMA++
Sbjct: 45 LSDYYFEHFSKLMLIPAEQSYLPFSQ----ALSYVVDNVLLEFFYLCFPLLTVAALMAIA 100

Query: 148 SSLL 151
S ++
Sbjct: 101 SHVV 104


11HELPY_0976HELPY_1000Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_0976023-4.692734Conserved hypothetical protein
HELPY_0977328-6.629409Biosynthetic arginine decarboxylase(ADC)
HELPY_0978423-5.986938Putative polysaccharide biosynthesis protein
HELPY_0980121-5.216839Conserved hypothetical protein
HELPY_0982219-4.781727Conserved hypothetical protein; putative
HELPY_0983218-4.787814Conserved hypothetical protein
HELPY_0984418-5.449157Methionyl-tRNA synthetase (Methionine--tRNA
HELPY_0985418-5.164653Cyclopropane-fatty-acyl-phospholipid synthase
HELPY_0986421-5.655445Conserved hypothetical protein; putative
HELPY_0987421-5.869351****Putative neuraminyllactose-binding hemagglutinin
HELPY_0988421-6.105084GMP synthase [glutamine-hydrolyzing] (Glutamine
HELPY_0989322-5.749036Conserved hypothetical protein
HELPY_0990327-4.990456Biotin sulfoxide reductase; putative signal
HELPY_0991127-4.173819Conserved hypothetical protein
HELPY_0992216-3.948339Putative cysteine desulfurase
HELPY_0993215-4.112990Putative hydrolase, Histidine triat (HIT)
HELPY_0994113-3.551359Phenylalanyl-tRNA synthetase alpha chain
HELPY_0996114-3.497112Phenylalanyl-tRNA synthetase beta chain
HELPY_1000214-3.2862743-phosphoshikimate 1-carboxyvinyltransferase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1014PF05211893e-23 Neuraminyllactose-binding hemagglutinin
		>PF05211#Neuraminyllactose-binding hemagglutinin

Length = 260

Score = 88.9 bits (220), Expect = 3e-23
Identities = 49/221 (22%), Positives = 109/221 (49%), Gaps = 22/221 (9%)

Query: 45 HYPIKGKQEPKNGHLVVLIDPKIEANKVIPENYQKEFEKSLFLQLSSFLERKGYSVSQF- 103
++P K + + ++L+ P + + I + Y+ +F+ L++ L+ +GY V
Sbjct: 44 YHPASEKVQALD-EKILLLRPAFQYSDNIAKEYENKFKNQTTLKVEQILQNQGYKVINVD 102

Query: 104 -KDASEIPQDIKEKALLVLRMDGNVAILEDI-----------VEESDALNEEKVIDMSSG 151
D + K++ L + M+G + + D + S L++ + + + +G
Sbjct: 103 SSDKDDFSFAQKKEGYLAVAMNGEIVLRPDPKRTIQKKSEPGLLFSTGLDKMEGVLIPAG 162

Query: 152 YLNLNFVEPKSEDIIHSFGIDVSK--IRAVIERVELRRTNSGGFVPKTFVHRIKETDHDQ 209
++ + +EP S + + SF +D+S+ I+ + ++SGG V K TD+
Sbjct: 163 FVKVTILEPMSGESLDSFTMDLSELDIQEKFLKTT-HSSHSGGLVSTMV----KGTDNSN 217

Query: 210 -AIRKIMNQAYHKVMVHITKELSKKHMERYEKVSSEMKKRK 249
AI+ +N+ + +M I K+L++K++E Y+K + E+K ++
Sbjct: 218 DAIKSALNKIFANIMQEIDKKLTQKNLESYQKDAKELKGKR 258


12HELPY_1071HELPY_1119Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_10712101.232439Conserved hypothetical protein
HELPY_10722111.308506Cysteine-rich protein X
HELPY_10733120.512904Gamma-glutamyltranspeptidase; putative signal
HELPY_10740131.259194Flagellar hook-associated protein 1 (HAP 1)
HELPY_10752142.007896Conserved hypothetical protein
HELPY_10760142.824649M.HpyAVIII, a type II cytosine specific DNA
HELPY_10770122.353088Anti-sigma 28 factor
HELPY_1078-1101.920401Conserved hypothetical protein; putative signal
HELPY_1081-211-0.455925FKBP-type peptidyl-prolyl cis-trans isomerase
HELPY_1083216-1.692743Conserved hypothetical protein
HELPY_1085213-0.687756Peptidoglycan-associated lipoprotein precursor;
HELPY_1087011-0.215794TonB-independent protein-uptake protein
HELPY_1090013-0.198160Conserved hypothetical protein; putative signal
HELPY_1092017-1.892291Biopolymer transport protein ExbD/TolR
HELPY_1094216-1.242876Biopolymer transport ExbB protein; putative
HELPY_1096415-1.923238ATP synthase F1, subunit epsilon (ATP synthase
HELPY_1098415-2.410091ATP synthase F1, subunit beta (ATPase subunit
HELPY_1099113-0.286036ATP synthase F1, subunit gamma (ATP synthase F1
HELPY_1100216-0.185044ATP synthase F1, subunit alpha
HELPY_11011152.222983ATP synthase F1, subunit delta
HELPY_11020151.992342ATP synthase F0, subunit b; putative signal
HELPY_11040141.588210ATP synthase F0, subunit b'; putative signal
HELPY_11060150.390704Putative plasmid replication-partition related
HELPY_1107-116-1.714520Putative SpoOJ regulator
HELPY_1108-117-1.032938BirA bifunctional protein [Includes: Biotin
HELPY_1109219-4.263936Methionyl-tRNA formyltransferase
HELPY_1110219-3.854252Conserved hypothetical protein
HELPY_1111318-4.295670Conserved hypothetical protein
HELPY_1112318-4.373554Conserved hypothetical protein
HELPY_1113319-4.044523Conserved hypothetical protein
HELPY_1115213-0.41869450S ribosomal protein L19
HELPY_11192140.019089tRNA (guanine-N(1)-)-methyltransferase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1091FLGHOOKAP15650.0 Flagellar hook-associated protein signature.
		>FLGHOOKAP1#Flagellar hook-associated protein signature.

Length = 546

Score = 565 bits (1458), Expect = 0.0
Identities = 129/610 (21%), Positives = 229/610 (37%), Gaps = 75/610 (12%)

Query: 6 SSLNTSYTGLQAHQSMVDVTGNNISNASDEFYSRQRVIAKPQAAYMYGTKNVNMGVDVEA 65
S +N + +GL A Q+ ++ NNIS+ + Y+RQ I + + V GV V
Sbjct: 2 SLINNAMSGLNAAQAALNTASNNISSYNVAGYTRQTTIMAQANSTLGAGGWVGNGVYVSG 61

Query: 66 IERVHDEFVFARYTKANYENTYYDTEFSHLKEASAYFPDIDEASLFTDLQDYFNSWKELS 125
++R +D F+ + A +++ + + + +SL T +QD+F S + L
Sbjct: 62 VQREYDAFITNQLRAAQTQSSGLTARYEQMSKIDNML-STSTSSLATQMQDFFTSLQTLV 120

Query: 126 KNAKDSAQKQALAQKTEALTHNIKDTRERLTTLQHKASEELKSVIKEVNSLGSQIAQINK 185
NA+D A +QAL K+E L + K T + L + + + + + ++N+ QIA +N
Sbjct: 121 SNAEDPAARQALIGKSEGLVNQFKTTDQYLRDQDKQVNIAIGASVDQINNYAKQIASLND 180

Query: 186 RIKEVENNKSLKHANELRDKRDELEFHLRELLGGNVFKSSIKTHSLTDKDSADFDESYNL 245
+I + + N L D+RD+L L +++G V S +YN+
Sbjct: 181 QISRLTGVGAGASPNNLLDQRDQLVSELNQIVGVEV--------------SVQDGGTYNI 226

Query: 246 NIGHGFNIIDGSIFHPLVVKESENKGGLNQVYFQSDDFKLTNITDK-LNQGKVGALLNVY 304
+ +G++++ GS L S V + I +K LN G +G +L
Sbjct: 227 TMANGYSLVQGSTARQLAAVPSSADPSRTTVAYVDGTAGNIEIPEKLLNTGSLGGILTFR 286

Query: 305 NDGSNGTLKGKLQDYIDLLDSFARGLIESTNAIYAQSASHHIEGEPVEFNSDEAFKDTNY 364
+ L + L A E+ N + +A D N
Sbjct: 287 SQ--------DLDQTRNTLGQLALAFAEAFNTQH------------------KAGFDANG 320

Query: 365 NIKNGSFDL----IAYNTDGKEIARKTIAITPITTMNDIIQAINANTDDNQ-----DNNT 415
+ F + + NT K +T + + I+ + + Q N T
Sbjct: 321 DAGEDFFAIGKPAVLQNTKNKGDVAIGATVTDASAVLATDYKISFDNNQWQVTRLASNTT 380

Query: 416 ENDFDDYFTASFNNETKKFVIQPKNASQGLFVSMKDNGTNFMGALKLNPFFQGDDASNIS 475
D + + + + + M L D + I+
Sbjct: 381 FTVTPDANGKVAFDGLELTFTGTPAVNDSFTLKPVSDAIVNMDVLI-------TDEAKIA 433

Query: 476 LNKEYKKEPTTIRPWLAPINGNFDVANMMQQLQYDSVDFYNDKFDIKPMKISEFYQFLTG 535
+ E E G+ D N L S N K ++ Y L
Sbjct: 434 MASE---EDA----------GDSDNRNGQALLDLQS----NSKTVGGAKSFNDAYASLVS 476

Query: 536 KINTDAEKSGRILDTKKSMLETIKKEQLSISQVSVDEEMVNLIKFQSGYAANAKVITAID 595
I T+ +++ + +Q SIS V++DEE NL +FQ Y ANA+V+ +
Sbjct: 477 DIGNKTATLKTSSATQGNVVTQLSNQQQSISGVNLDEEYGNLQRFQQYYLANAQVLQTAN 536

Query: 596 RMIDTLLGIK 605
+ D L+ I+
Sbjct: 537 AIFDALINIR 546


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1098OMPADOMAIN1462e-45 OMPA domain signature.
		>OMPADOMAIN#OMPA domain signature.

Length = 346

Score = 146 bits (371), Expect = 2e-45
Identities = 48/169 (28%), Positives = 75/169 (44%), Gaps = 24/169 (14%)

Query: 22 KMDNKTVAGDVSAKTVQTAPV-TTEPAPEKEEPKQEPAPVVEEKPAVESGTIIASIYFDF 80
+ DN ++ VS + Q PAP PAP V+ K T+ + + F+F
Sbjct: 177 RPDNGMLSLGVSYRFGQGEAAPVVAPAPA-------PAPEVQTK----HFTLKSDVLFNF 225

Query: 81 DKYEIKESDQETLDEIVQKAKE---NHMQVLLEGNTDEFGSSEYNQALGVKRTLSVKNAL 137
+K +K Q LD++ + V++ G TD GS YNQ L +R SV + L
Sbjct: 226 NKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGLSERRAQSVVDYL 285

Query: 138 VIKGVEKDMIKTISFGETKPKC-----AQKTR----ECYKENRRVDVKL 177
+ KG+ D I GE+ P K R +C +RRV++++
Sbjct: 286 ISKGIPADKISARGMGESNPVTGNTCDNVKQRAALIDCLAPDRRVEIEV 334


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1100TYPE4SSCAGA290.035 Type IV secretion system CagA exotoxin signature.
		>TYPE4SSCAGA#Type IV secretion system CagA exotoxin signature.

Length = 1147

Score = 28.5 bits (63), Expect = 0.035
Identities = 37/145 (25%), Positives = 66/145 (45%), Gaps = 14/145 (9%)

Query: 32 KEAEKILLDLGKKNEQVID--LNLEDLPSNEKKDEKIAEKAEEKKDEKVVEKNATDKEGD 89
+EA K++ D N++++ LN ++ K E KK +K +EK+ +E
Sbjct: 568 QEANKLIKDFLSSNKELVGKTLNFNKAVADAKN---TGNYDEVKKAQKDLEKSLRKREHL 624

Query: 90 FIDPKEQEESLENIFSSLNDFQEKTDTNAQKDE-----QKNEQEEQRRLKEQQRLRKNQK 144
KE E+ LE+ + N + K N+QKDE K + R + Q L+ ++
Sbjct: 625 ---EKEVEKKLESKSGNKNKMEAKAQANSQKDEIFALINKEANRDARAIAYAQNLKGIKR 681

Query: 145 N-QEMLKGLQQNLDQFAQKLESVKN 168
+ L+ + +NL F + + KN
Sbjct: 682 ELSDKLENVNKNLKDFDKSFDEFKN 706


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1106ECOLIPORIN300.025 E.coli/Salmonella-type porin signature.
		>ECOLIPORIN#E.coli/Salmonella-type porin signature.

Length = 383

Score = 29.9 bits (67), Expect = 0.025
Identities = 20/68 (29%), Positives = 35/68 (51%), Gaps = 3/68 (4%)

Query: 196 YVAIGQKESTVAQVVRKLEEYGAMEYSVVINASASDSAAMQYLAPYSGVAMGEYFR-DHA 254
Y+ +G K T Q+ +L YG EY+V N + + A ++G+ G+Y D+
Sbjct: 56 YMRVGFKGET--QINDQLTGYGQWEYNVQANTTEGEGANSWTRLAFAGLKFGDYGSFDYG 113

Query: 255 RHALIIYD 262
R+ ++YD
Sbjct: 114 RNYGVLYD 121


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1111PF07675310.004 Cleaved Adhesin
		>PF07675#Cleaved Adhesin

Length = 1358

Score = 31.2 bits (70), Expect = 0.004
Identities = 30/105 (28%), Positives = 40/105 (38%), Gaps = 7/105 (6%)

Query: 70 QISQVILKTQMPFLDLVPSNLGLAGFEKTFYDSQDENKRGELMLKNALESVV---GLYDY 126
VI T F SNL A FE + D + ++ VV G+YDY
Sbjct: 414 TFGSVIPATGPLFTGTASSNLYSANFEYLTPANADPVVTTQNIIVTGQGEVVIPGGVYDY 473

Query: 127 IIIDSPPALGPLTINSLSAAHSVIIPIQCEFFALEGTKLLLNTIR 171
I + PA G + I A P + + FA E K T+R
Sbjct: 474 CITNPEPASGKMWI----AGDGGNQPARYDDFAFEAGKKYTFTMR 514


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1113FERRIBNDNGPP320.002 Ferrichrome-binding periplasmic protein signature.
		>FERRIBNDNGPP#Ferrichrome-binding periplasmic protein signature.

Length = 296

Score = 32.2 bits (73), Expect = 0.002
Identities = 12/33 (36%), Positives = 20/33 (60%)

Query: 70 EPEVQILKDLKPDFIVVVAYGKILPKEVLTIAP 102
EP +++L ++KP F+V A P+ + IAP
Sbjct: 86 EPNLELLTEMKPSFMVWSAGYGPSPEMLARIAP 118


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1115RTXTOXIND431e-06 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 43.3 bits (102), Expect = 1e-06
Identities = 25/184 (13%), Positives = 65/184 (35%), Gaps = 18/184 (9%)

Query: 37 LAQQKEFEKEVNEKRAQYLSYFKNLEQKEEALKEREKEQKAKFDDAVKQASALALQDERA 96
++E + + + Q+ ++ QKE L ++ E+ + + ++ R
Sbjct: 178 NVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSRVEKSRL 237

Query: 97 KIIEEARKNAFLEQQKGLELLQKELEEKSKQVQELHQKEAEIERLKRENNEAESRLKAEN 156
+ + LE K +E EL ++++E+++ E A+ +
Sbjct: 238 DDFSSLLHKQAIAKHAVLEQENKYVEAV----NELRVYKSQLEQIESEILSAKEEYQLVT 293

Query: 157 EKKLNEKLDLEREKIEKALHEKNELKFKQQEEQLEMLRNELKNAQRKAELSSQQFQGEVQ 216
+ + E ++K + +L + + +A +S +VQ
Sbjct: 294 Q-------LFKNEILDK--LRQTTDNIGLLTLELAKNEERQQASVIRAPVS-----VKVQ 339

Query: 217 ELAI 220
+L +
Sbjct: 340 QLKV 343


13HELPY_1214HELPY_1231Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_12141123.457155Conserved hypothetical protein
HELPY_12150133.47936930S ribosomal subunit protein S18
HELPY_12161123.697697Single-stranded DNA-binding protein (SSB)
HELPY_12174203.64637830S ribosomal subunit protein S6
HELPY_12182162.395423DNA polymerase III delta subunit
HELPY_1219-1121.078781Ribonuclease R (RNase R) (Protein VacB)
HELPY_1220112-0.917114Shikimate dehydrogenase
HELPY_1221111-0.982916Conserved hypothetical protein; putative signal
HELPY_122219-0.991570ABC-type transport system, permease; putative
HELPY_1223310-0.896202ABC-type transport system, periplasmic
HELPY_122419-0.358520Tryptophanyl-tRNA synthetase (Tryptophan--tRNA
HELPY_1225011-0.284843Biotin biosynthesis protein BioC
HELPY_1226010-0.188945Protein-export membrane protein SecG
HELPY_1227-110-0.082614Ribosome recycling factor (Ribosome releasing
HELPY_1228-1110.034634Orotate phosphoribosyltransferase (OPRT)
HELPY_12291130.102950Conserved hypothetical protein; putative
HELPY_12301130.898338Putative NAD+-dependent deacetylase, Sir2
HELPY_12313151.702864NADH-ubiquinone oxidoreductase, NQO7 subunit
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1221INVEPROTEIN270.035 Salmonella/Shigella invasion protein E (InvE) signat...
		>INVEPROTEIN#Salmonella/Shigella invasion protein E (InvE)

signature.
Length = 372

Score = 27.4 bits (60), Expect = 0.035
Identities = 14/76 (18%), Positives = 28/76 (36%), Gaps = 7/76 (9%)

Query: 49 CFIDARLFGRTAEIANQYLSKGSSVLIEGRLT----YESWMDQTGKKNSRHTIT--VDSL 102
C + ARLFG+T + L I+ Y W+ G R + ++
Sbjct: 168 CALKARLFGKTLSLKPGLLRASYRQFIQSESHEVEIYSDWIASYG-YQRRLVVLDFIEGS 226

Query: 103 QFMDKKSDNPQANAMQ 118
D +++ + ++
Sbjct: 227 LLTDIDANDASCSRLE 242


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1226IGASERPTASE374e-05 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 36.6 bits (84), Expect = 4e-05
Identities = 17/88 (19%), Positives = 33/88 (37%), Gaps = 3/88 (3%)

Query: 48 AEKTETERQNSALPPKQEEANTATTATEENPTKDTAPPLETTAQEKETKQETKQEQEKEN 107
+ E + S + PKQE++ T E D ++ + T +T+Q ++ +
Sbjct: 1117 EKTQEVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQTNTTADTEQPAKETS 1176

Query: 108 EPKQNSVPPVQNNQKTPTTPLMGKKPLE 135
N PV + T + + P
Sbjct: 1177 ---SNVEQPVTESTTVNTGNSVVENPEN 1201



Score = 33.1 bits (75), Expect = 8e-04
Identities = 20/86 (23%), Positives = 36/86 (41%), Gaps = 3/86 (3%)

Query: 38 KKDSAPISPNAEKTETERQNSALPPKQEEANTATTATEENPTKDTAPPLETTAQEKETKQ 97
+ + + N E + + N + E + + T+E T +T ET EKE K
Sbjct: 1056 QDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETK---ETATVEKEEKA 1112

Query: 98 ETKQEQEKENEPKQNSVPPVQNNQKT 123
+ + E+ +E + V P Q +T
Sbjct: 1113 KVETEKTQEVPKVTSQVSPKQEQSET 1138



Score = 32.7 bits (74), Expect = 8e-04
Identities = 20/82 (24%), Positives = 31/82 (37%), Gaps = 6/82 (7%)

Query: 48 AEKTETERQNSALPPKQEEANTATTATEENPTKDTAPPLETTAQEKETKQETKQEQ---E 104
+E ET+ + E+ A TE+ P + + K+ + ET Q Q
Sbjct: 1090 SETKETQTTETKETATVEKEEKAKVETEK---TQEVPKVTSQVSPKQEQSETVQPQAEPA 1146

Query: 105 KENEPKQNSVPPVQNNQKTPTT 126
+EN+P N P T T
Sbjct: 1147 RENDPTVNIKEPQSQTNTTADT 1168



Score = 27.3 bits (60), Expect = 0.045
Identities = 16/95 (16%), Positives = 32/95 (33%), Gaps = 11/95 (11%)

Query: 35 FYVKKDSAPISPNAEKTETERQNSALPPKQEEANTATTAT---EENPTKDTAPPLETTAQ 91
+K+ + + A+ + ++ S+ + +T ENP T
Sbjct: 1153 VNIKEPQSQTNTTADTEQPAKETSSNVEQPVTESTTVNTGNSVVENPENTT-----PATT 1207

Query: 92 EKETKQETKQEQEKENEPKQNSVPPVQNNQKTPTT 126
+ E+ K + SV V +N + TT
Sbjct: 1208 QPTVNSES---SNKPKNRHRRSVRSVPHNVEPATT 1239


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1231SECGEXPORT495e-10 Protein-export SecG membrane protein signature.
		>SECGEXPORT#Protein-export SecG membrane protein signature.

Length = 110

Score = 48.8 bits (116), Expect = 5e-10
Identities = 25/84 (29%), Positives = 47/84 (55%), Gaps = 3/84 (3%)

Query: 3 MTSALLGLQIVLAVLIVVVVLLQ--KSSSIGLGAYSGSNESLFGAKGPASFMAKLTMFLG 60
M ALL + +++A+ +V +++LQ K + +G +G++ +LFG+ G +FM ++T L
Sbjct: 1 MYEALLVVFLIVAIGLVGLIMLQQGKGADMGASFGAGASATLFGSSGSGNFMTRMTALLA 60

Query: 61 LLFVINTIALGYFYNKEYGKSILD 84
LF I ++ LG N +
Sbjct: 61 TLFFIISLVLGNI-NSNKTNKGSE 83


14HELPY_1327HELPY_1339Y        NYGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_1327333-3.400206Serine recombinase-transposase, OrfA, ISHp609
HELPY_1328632-5.160716Transposase, OrfB, ISHp609
HELPY_1329426-3.576856Putative phosphorylase
HELPY_1330522-3.358127Type II restriction endonuclease
HELPY_1331424-3.211486Type II m6A methylase
HELPY_1332320-3.716425Nicotinate-nucleotide pyrophosphorylase
HELPY_1333320-3.709628Quinolinate synthetase A
HELPY_1335114-5.605743Phosphatidylserine decarboxylase proenzyme
HELPY_1338115-4.532178Conserved hypothetical protein
HELPY_1339-113-3.029216Conserved hypothetical protein
15HELPY_1402HELPY_1423Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_1402-117-4.055751tRNA modification GTPase
HELPY_1403016-2.793016Outer membrane protein HomD; putative signal
HELPY_1404017-2.552551Hypothetical protein
HELPY_1405220-2.220830Conserved hypothetical protein; putative signal
HELPY_1406418-1.997107Conserved hypothetical protein; putative signal
HELPY_1407218-1.236093Membrane-associated lipoprotein; putative signal
HELPY_1408116-0.441860Conserved hypothetical protein; putative signal
HELPY_14110160.045021Thioredoxin
HELPY_1412118-0.635820Ribosomal large subunit pseudouridine synthase
HELPY_1413221-1.647579DNA polymerase III alpha subunit
HELPY_1414219-2.023363Putative di-haem cytochrome c peroxidase;
HELPY_1415220-1.885514Conserved hypothetical protein
HELPY_1416217-0.048008Conserved hypothetical protein; putative signal
HELPY_1417218-0.943320ABC-type transport system, periplasmic
HELPY_CDS1399748D017-0.556999ABC-type transport system, ATP binding protein
HELPY_14180170.351134ABC-type transport system, permease; putative
HELPY_14190160.500895Putative outer membrane protein; putative signal
HELPY_14200130.151980Branched-chain-amino-acid aminotransferase
HELPY_14210120.152908Outer membrane protein HorJ; putative signal
HELPY_14220100.563769DNA polymerase I (DNA nucleotidyltransferase
HELPY_14232101.257695Conserved hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1422TCRTETOQM340.002 Tetracycline resistance protein TetO/TetQ/TetM family ...
		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

signature.
Length = 639

Score = 33.7 bits (77), Expect = 0.002
Identities = 32/134 (23%), Positives = 54/134 (40%), Gaps = 25/134 (18%)

Query: 216 LSIVGKPNAGKSSLLNAMLLEERA---LVSDIKGTTR-DTIEE-------------VIEL 258
+ ++ +AGK++L ++L A L S KGTTR D +
Sbjct: 6 IGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGITSFQW 65

Query: 259 KGHKVRLIDTAGIRESTDKIERLGIEKSLKSLENCDIILGVFDLSKPLEKEDFTIIDALN 318
+ KV +IDT G + ++ R SL L D + + ++ + + AL
Sbjct: 66 ENTKVNIIDTPGHMDFLAEVYR-----SLSVL---DGAILLISAKDGVQAQTRILFHALR 117

Query: 319 RAKKPCIVVLNKND 332
+ P I +NK D
Sbjct: 118 KMGIPTIFFINKID 131


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1425BINARYTOXINB280.048 Binary toxin B family signature.
		>BINARYTOXINB#Binary toxin B family signature.

Length = 764

Score = 28.1 bits (62), Expect = 0.048
Identities = 13/60 (21%), Positives = 21/60 (35%)

Query: 155 SKSMGDLLAKAMPIERILKAYSVPVGSLENYEKIYYQNAFKPKVQITFDNNSDTEIKAAL 214
+ + D L P + +A + G E + YQ + FD + IK L
Sbjct: 536 AVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQL 595


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1427LIPOLPP20294e-105 LPP20 lipoprotein precursor signature.
		>LIPOLPP20#LPP20 lipoprotein precursor signature.

Length = 175

Score = 294 bits (753), Expect = e-105
Identities = 173/175 (98%), Positives = 174/175 (99%)

Query: 1 MKNQVKKILGMSVIATMVIVGCSHAPKSGISKSNKAYKEATKGAPDWVVGDLEKVAKYEK 60
MKNQVKKILGMSV+A MVIVGCSHAPKSGISKSNKAYKEATKGAPDWVVGDLEKVAKYEK
Sbjct: 1 MKNQVKKILGMSVVAAMVIVGCSHAPKSGISKSNKAYKEATKGAPDWVVGDLEKVAKYEK 60

Query: 61 YSGVFLGRAEDLITNNDVDYSTNQATAKARANLAANLKSTLQKDLENEKTRTVDASGKRS 120
YSGVFLGRAEDLITNNDVDYSTNQATAKARANLAANLKSTLQKDLENEKTRTVDASGKRS
Sbjct: 61 YSGVFLGRAEDLITNNDVDYSTNQATAKARANLAANLKSTLQKDLENEKTRTVDASGKRS 120

Query: 121 ISGTDTEKISQLVDKELIASKMLARYVGKDRVFVLVGLDKQIVDKVREELGMVKK 175
ISGTDTEKISQLVDKELIASKMLARYVGKDRVFVLVGLDKQIVDKVREELGMVKK
Sbjct: 121 ISGTDTEKISQLVDKELIASKMLARYVGKDRVFVLVGLDKQIVDKVREELGMVKK 175


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1436FLAGELLIN290.016 Flagellin signature.
		>FLAGELLIN#Flagellin signature.

Length = 507

Score = 29.2 bits (65), Expect = 0.016
Identities = 13/34 (38%), Positives = 24/34 (70%)

Query: 177 LASVDDLIANLDSRKTQFDSLISNANNLVSNVNN 210
L+ VD + ++L + + +FDS I+N N V+N+N+
Sbjct: 428 LSKVDAVRSSLGAIQNRFDSAITNLGNTVTNLNS 461


16HELPY_1438HELPY_1449Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_14382130.571853Putative ABC-type transport system, permease;
HELPY_14394110.338379Conserved hypothetical protein
HELPY_1440210-0.096309Putative outer membrane transporter; putative
HELPY_1441311-0.722223Putative TlyC-like hemolysin; putative membrane
HELPY_1442312-1.020430Transporter; putative phosphate transporter;
HELPY_1443215-0.781115Putative nifU-like protein
HELPY_14442140.128797Conserved hypothetical protein
HELPY_14453170.259477UDP-N-acetylmuramoylalanyl-D-glutamate--2,
HELPY_14463120.598657Transaldolase
HELPY_14473110.28448250S ribosomal subunit protein L25
HELPY_14492130.752101Peptidyl-tRNA hydrolase (PTH)
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1461RTXTOXIND461e-07 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 46.0 bits (109), Expect = 1e-07
Identities = 27/200 (13%), Positives = 63/200 (31%), Gaps = 29/200 (14%)

Query: 8 KNKAILTGGGALLLGLIVLFYLAYRP--KAEVLQGFL--EAREYSVSSKVPGRIEKVFVK 63
+ L + +I G L R + ++++ VK
Sbjct: 54 SRRPRLVAYFIMGFLVIAFILSVLGQVEIVATANGKLTHSGRSKEIKPIENSIVKEIIVK 113

Query: 64 KGDHIKKGDLVFSISSPELEAKLAQAEAGHKAAK-------ALSDEVKRGSRDETINSAR 116
+G+ ++KGD++ +++ EA + ++ A+ LS ++ E
Sbjct: 114 EGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDE 173

Query: 117 DVWQAAKSQATLAKETYKRVQDLYDNGVASLQKRDEAYAAYESTKYNESAAYQKYKMALG 176
+Q ++E R+ L E ++ +++ KY + K +
Sbjct: 174 PYFQNV------SEEEVLRLTSLI----------KEQFSTWQNQKYQKELNLDKKRAERL 217

Query: 177 GASSESKIAAKAKESAALGQ 196
++I S
Sbjct: 218 TV--LARINRYENLSRVEKS 235


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1464ALARACEMASE290.039 Alanine racemase signature.
		>ALARACEMASE#Alanine racemase signature.

Length = 356

Score = 29.4 bits (66), Expect = 0.039
Identities = 12/59 (20%), Positives = 26/59 (44%), Gaps = 2/59 (3%)

Query: 56 IGGYMAMNIGANDVSNNVGPAVGSKAISMGGAILIAAICEMLGAIIAGGEVVSTIKGRI 114
G ++M++ A D++ +G+ G I I + G + G E++ + R+
Sbjct: 295 TVGTVSMDMLAVDLTPCPQAGIGTPVELWGKEIKIDDVAAAAGTV--GYELMCALALRV 351


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1467DHBDHDRGNASE320.005 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase sig...
		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

signature.
Length = 261

Score = 31.6 bits (71), Expect = 0.005
Identities = 25/127 (19%), Positives = 44/127 (34%), Gaps = 22/127 (17%)

Query: 238 YQQDLRDP-NLKEIALMHSPLLGRYNLYNILAGVLGVKLLTQLPLETIAPLLE-NFYGVK 295
+ D+RD + EI +G ++ +AGVL L+ L E N GV
Sbjct: 62 FPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGV- 120

Query: 296 GRLEIVHSKPLVVVDFAHTTDGMQQVFESFKNQKITALFGAGGDRDKTKRPKMGAIASCY 355
+ + V + +++ ++ G + R M A AS
Sbjct: 121 -------------------FNASRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSK 161

Query: 356 AHQIILT 362
A ++ T
Sbjct: 162 AAAVMFT 168


17HELPY_1480HELPY_1538Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_14802132.887012Conserved hypothetical protein; putative signal
HELPY_14811122.003213Putative outer membrane protein
HELPY_1482-1101.908283Putative exodeoxyribonuclease
HELPY_1483-2100.684003*DNA transformation competence protein ComH;
HELPY_1484-1100.689178Chromosomal replication initiator protein DnaA
HELPY_1485-2100.401200Putative purine nucleoside phosphorylase PunB
HELPY_1487010-3.101254Conserved hypothetical protein
HELPY_1489011-3.564098Glucosamine--fructose-6-phosphate
HELPY_1490-110-3.199438Thymidylate synthase thyX (TS) (TSase)
HELPY_1491010-3.188370Conserved hypothetical protein
HELPY_1492113-3.552109Putative type I R-M system specificity subunit
HELPY_1493113-3.481679Type I restriction-modification enzyme subunit
HELPY_1494112-3.005003Type I restriction-modification enzyme subunit
HELPY_1495114-1.285754Conserved hypothetical protein
HELPY_1496015-1.031695Iron(III) dicitrate transport protein FecA
HELPY_1497014-0.930501Arginase
HELPY_1498012-0.314312Alanine dehydrogenase
HELPY_1499112-0.052177Conserved hypothetical protein
HELPY_1500316-0.084674Outer membrane protein HorL; putative signal
HELPY_1501116-2.105166Probable inorganic polyphosphate/ATP-NAD kinase
HELPY_1502012-2.031386DNA repair protein
HELPY_1503011-2.341899Putative fibronectin/fibrinogen-binding protein
HELPY_1504-113-3.259818Conserved hypothetical protein
HELPY_1505-211-0.940755Putative Hac prophage II protein
HELPY_1507-2100.483771Putative Hac prophage II integrase
HELPY_1508-1100.192011Putative Hac prophage II protein
HELPY_15101102.214807Putative Hac prophage II protein
HELPY_1513-17-1.283862Putative Hac prophage II protein
HELPY_151419-2.221595Putative Hac prophage II protein
HELPY_1515211-1.178202Putative Hac prophage II protein
HELPY_1516514-2.299108Transposase, OrfB, ISHp609
HELPY_1517716-3.213410Serine recombinase-transposase, OrfA, ISHp609
HELPY_1518520-4.859302Conserved hypothetical protein
HELPY_1520628-4.463817Conserved hypothetical protein
HELPY_1522427-6.589903Cysteine-rich protein G
HELPY_1523223-4.636047DNA polymerase III epsilon subunit
HELPY_1524324-4.654488D-ribulose-5-phosphate 3-epimerase
HELPY_1525324-4.425229Fructose-1,6-bisphosphatase
HELPY_1527527-4.252448Conserved hypothetical protein
HELPY_1528426-3.694892Putative N-6 Adenine-specific DNA methylase
HELPY_1529627-3.261530Conserved hypothetical protein
HELPY_1530624-3.205940Ubiquinol cytochrome c oxidoreductase,
HELPY_1532217-1.448065Ubiquinol cytochrome c oxidoreductase,
HELPY_1534013-1.752312Ubiquinol cytochrome c oxidoreductase, 2Fe-2S
HELPY_1535-113-1.593998Transcription-repair coupling factor
HELPY_1536-114-0.742304Conserved hypothetical protein
HELPY_1537113-0.175384Zn-metallopeptidase, M23 family
HELPY_15382131.139452Zn-metallopeptidase, M23 family
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1500HTHFIS355e-04 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 35.2 bits (81), Expect = 5e-04
Identities = 9/51 (17%), Positives = 24/51 (47%), Gaps = 4/51 (7%)

Query: 125 TVYEIAKKVAQSDTPPYNPVLFYGGTGLGKTHILNAIGNHALEKHKKVVLV 175
+Y + ++ Q+D ++ G +G GK + A+ ++ ++ V +
Sbjct: 148 EIYRVLARLMQTDLT----LMITGESGTGKELVARALHDYGKRRNGPFVAI 194


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1518FbpA_PF058331119e-29 Fibronectin-binding protein
		>FbpA_PF05833#Fibronectin-binding protein

Length = 577

Score = 111 bits (280), Expect = 9e-29
Identities = 77/401 (19%), Positives = 152/401 (37%), Gaps = 29/401 (7%)

Query: 54 KKPPESVLKNTLALDFCLNKFTKNAKILQANIIDNDRILEIKGAKDLAYKSENFILRLEM 113
K P + + N N I + L + ++ ++ +N + L +
Sbjct: 170 KLNPFDFSYDMIENFTKENSLQLNDNIFSKIFTGVSKTL----SSEICFRLKNNSIDLSL 225

Query: 114 IPKKANLMILDKEKCVIEA--FRFNDRVAKNDILGALPPN-IYEHQEEDLDFKDLLEILE 170
K + + I++ F FN N +G N + + + + + ++LE
Sbjct: 226 SNLKEIVEVCKDLFKEIQSNKFEFNCYTKNNSFVGFYCLNLMSKEDYKKIQYDSSSKLLE 285

Query: 171 KDFLSYQHKE-LEHKKNQIIKRLNIQKERLKEKLEKLEDPKNLQLEAKELQTQASLLLTY 229
+ + + L+ K + + K + R +K + L + + + LL
Sbjct: 286 NFYYAKDKSDRLKSKSSDLQKIVMNNINRCTKKDKILNNTLKKCEDKDIFKLYGELLTAN 345

Query: 230 QHLIHKHESRVVLKDFED---KECTIEIDKSMPLNAFINKKFTLSKKKKQKSQFLYLEEE 286
+ + K S + L ++ I +D++ + + + K K+ + +
Sbjct: 346 IYALKKGLSHIELANYYSENYDTVKITLDENKTPSQNVQSYYKKYNKLKKSEEAANEQLL 405

Query: 287 NLKEKIAFKENQINYVKGAQEESVLE------------MFMPFKNSKIKRPMSGYEVLYY 334
+E++ + + + + A +E F SK + +
Sbjct: 406 QNEEELNYLYSVLTNINNADNYDEIEEIKKELIETGYIKFKKIYKSKKSKTSKPMHFISK 465

Query: 335 KDFKIGLGKNQKENIKL-LQDARANDLWMHVRNIPGSHLIVFCQKNAPKDEVIMELAKML 393
I +GKN +N L L+ A +D+W H +NIPGSH+IV + P + ++E A +
Sbjct: 466 DGIDIYVGKNNIQNDYLTLKFANKHDIWFHTKNIPGSHVIVKNIMDIP-ESTLLEAANLA 524

Query: 394 IKMQKDVFNS-YEIDYTQRKFVKIIKGAN---VIYSKYRTI 430
K +S +DYT+ K VK GA VIYS +TI
Sbjct: 525 AYYSKSQNSSNVPVDYTEVKNVKKPNGAKPGMVIYSTNQTI 565



Score = 34.8 bits (80), Expect = 6e-04
Identities = 21/92 (22%), Positives = 49/92 (53%), Gaps = 5/92 (5%)

Query: 46 NAPYIGLSKKPPESVLKNTLALDFCLNKFTKNAKILQANIIDNDRI--LEIKGAKDLAYK 103
N P I L+ + +K + L K+ NAKI+ + I+ DRI ++ + +L +
Sbjct: 55 NYPRIHLTDLTKPNPIKAPMFCMV-LRKYISNAKIVDIHQINQDRIVVIDFESTDELGFN 113

Query: 104 SENFILRLEMIPKKANLMILDK-EKCVIEAFR 134
S + L +E++ + +N+ ++ K + ++++ +
Sbjct: 114 SI-YSLIIEIMGRHSNMTLIRKRDNIIMDSIK 144


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1546PF01540320.004 Adhesin lipoprotein
		>PF01540#Adhesin lipoprotein

Length = 475

Score = 31.6 bits (71), Expect = 0.004
Identities = 14/61 (22%), Positives = 28/61 (45%)

Query: 48 LLVLNQEIKNIDKQHALITKEFEKKKETNEKLSLQMDEFLDDLQLSGERVNDLEEVVGVN 107
LL L+++I++ AL + E+K + +EK Q+ ++ L V V +
Sbjct: 252 LLKLSEKIQSFADTIALTITKLERKFQIDEKFKKQLISTIELLNKKSVEVKTFATVNTIK 311

Query: 108 R 108
+
Sbjct: 312 K 312


18HELPY_0036HELPY_0041N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_0036-2140.322989DNA transformation competence protein ComB8
HELPY_0037-2140.423882DNA transformation competence protein ComB9;
HELPY_0038-2121.316084DNA transformation competence protein ComB10;
HELPY_0039-2121.080824Alginate biosynthesis protein AlgA
HELPY_0040-1121.221822GDP-mannose 4,6-dehydratase (GDP-D-mannose
HELPY_0041-2120.591444Bifunctional [GDP-fucose synthetase:
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0036PF043351332e-40 VirB8 type IV secretion protein
		>PF04335#VirB8 type IV secretion protein

Length = 227

Score = 133 bits (336), Expect = 2e-40
Identities = 37/202 (18%), Positives = 73/202 (36%), Gaps = 4/202 (1%)

Query: 40 QSVFRLERNRLKIAYKLLGLMSFIALILAIVLISVLPLQKTEHHF--VDFLNQDKHYAII 97
+ K+A+ + G+ +A + + ++ PL+ E + VD + A
Sbjct: 22 RDKLAAAERSKKLAWVVAGVAGALATAGVVAVAALTPLKTVEPYVITVDRNTGEASIAAK 81

Query: 98 QRADKSISSNEALARSLIGAYVLNRESINRIDDKSRYELVRLQSSSKVWQRFEDLIKTQN 157
D +I+ +EA+ + + YV RE + ++ V + S+ R+ KT N
Sbjct: 82 LHGDATITYDEAVRKYFLATYVRYREGWIAAAREEYFDAVMVMSARPEQDRWSRFYKTDN 141

Query: 158 SIYAQSHLEREVHI-VNIAIYQQDNNPIASVSIAAKLLNENKLVYEKRYKIVLSYLFDTP 216
Q+ L + V I +A V + + + + + Y D
Sbjct: 142 PQSPQNILANRTDVFVEIKRVSFLGGNVAQVYFTKESVTGSNST-KTDAVATIKYKVDGT 200

Query: 217 DFDYASMPKNPTGFKITRYSIT 238
KNP G+++ Y
Sbjct: 201 PSKEVDRFKNPLGYQVESYRAD 222


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0037TYPE4SSCAGX310.007 Type IV secretion system CagX conjugation protein si...
		>TYPE4SSCAGX#Type IV secretion system CagX conjugation protein

signature.
Length = 522

Score = 30.9 bits (69), Expect = 0.007
Identities = 23/86 (26%), Positives = 44/86 (51%), Gaps = 13/86 (15%)

Query: 183 TNNKPLKEETLKEEKEETKEKEEETITIGDNTNAMKIVKKDIQKGYKALKSSQRKWYCLG 242
+N + + +E ++EEK++ + + + NA+K + + + Y ++ +
Sbjct: 358 SNEQIINKEKIREEKQKIILDQAKALETQYVHNALK--RNPVPRNYNYYQAPE------- 408

Query: 243 ICSKKSKLSLMPKEIFNDKQFTYFKF 268
K+SK +MP EIF+D FTYF F
Sbjct: 409 ---KRSK-HIMPSEIFDDGTFTYFGF 430


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0040NUCEPIMERASE881e-21 Nucleotide sugar epimerase signature.
		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

Length = 334

Score = 87.9 bits (218), Expect = 1e-21
Identities = 46/180 (25%), Positives = 72/180 (40%), Gaps = 19/180 (10%)

Query: 7 LITGVTGQDGSYLAEYLLNLGYEVHGLKRRSSSINTSRIDHLYEDLHSDHKRRFFLHYGD 66
L+TG G G ++++ LL G++V G+ + + S E L F H D
Sbjct: 4 LVTGAAGFIGFHVSKRLLEAGHQVVGIDNLNDYYDVSLKQARLELLAQP---GFQFHKID 60

Query: 67 MTDSSNLIHLIATTKPTEIYNLAAQSHVKVSFETPEYTANADGIGTLRILEAMRILGLEK 126
+ D + L A+ ++ + V+ S E P A+++ G L ILE R ++
Sbjct: 61 LADREGMTDLFASGHFERVFISPHRLAVRYSLENPHAYADSNLTGFLNILEGCRHNKIQ- 119

Query: 127 KTRFYQASTSELYGEVLETPQNENTPF-------NPRSPYAVAKMYAFYITKNYREAYNL 179
AS+S +YG N PF +P S YA K + Y Y L
Sbjct: 120 --HLLYASSSSVYGL------NRKMPFSTDDSVDHPVSLYAATKKANELMAHTYSHLYGL 171


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0041NUCEPIMERASE542e-10 Nucleotide sugar epimerase signature.
		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

Length = 334

Score = 54.4 bits (131), Expect = 2e-10
Identities = 53/346 (15%), Positives = 108/346 (31%), Gaps = 54/346 (15%)

Query: 5 ILITGAYGMVGQNTALYFKKNKPDV-----------TLLTPKKSELY-----------LL 42
L+TGA G +G + + + V L + EL L
Sbjct: 3 YLVTGAAGFIGFHVSKRLLEAGHQVVGIDNLNDYYDVSLKQARLELLAQPGFQFHKIDLA 62

Query: 43 DKDNVQAYLKEYKPTGIIHCAGRVGGIVANMNDLSTYMVENLLMGLYLFSSALDSGVKKA 102
D++ + + R + ++ + Y NL L + + ++
Sbjct: 63 DREGMTDLFASGHFERVFISPHR-LAVRYSLENPHAYADSNLTGFLNILEGCRHNKIQHL 121

Query: 103 INLASSCAYPKYAPNPLKESDLLNGSLEPTNEGYALAKLSVMKYCEYVSAEKGVSYKTLV 162
+ +SS Y P D ++ + YA K + S G+ L
Sbjct: 122 LYASSSSVYGLNRKMPFSTDDSVDHPVSL----YAATKKANELMAHTYSHLYGLPATGLR 177

Query: 163 PCNLYGEFDKFEEKIAHMIPGLIARMHTAKLKNEKEFAMWGDGTARREYLNAKDLARFIA 222
+YG + + P + T + K ++ G +R++ D+A I
Sbjct: 178 FFTVYGPWGR---------PDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIAEAII 228

Query: 223 LAYDNIAS----------MPS-------VMNVGSGVDYSIEEYYEKVAQVLDYKGVFVKD 265
D I P+ V N+G+ + +Y + + L +
Sbjct: 229 RLQDVIPHADTQWTVETGTPAASIAPYRVYNIGNSSPVELMDYIQALEDALGIEAKKNML 288

Query: 266 LSKPVGMQQKLMDISK-QKALKWELEIPLEQGIKEAYEYYLKLLEV 310
+P + + D + + + E ++ G+K +Y +V
Sbjct: 289 PLQPGDVLETSADTKALYEVIGFTPETTVKDGVKNFVNWYRDFYKV 334


19HELPY_0246HELPY_0255N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_0246113-2.205560Neutrophil activating protein NapA
HELPY_0247-114-0.270624Putative signal-transducing protein AtoS,
HELPY_0249-2120.847452conserved hypothetical protein
HELPY_0251-3102.022822Flagellar P-ring protein precursor (Basal body
HELPY_0252-2122.116938ATP-dependent RNA helicase, DEAD-box family
HELPY_0253-1101.740919Conserved hypothetical protein
HELPY_0254-291.260932Conserved hypothetical protein
HELPY_0255-392.134811ABC-type transport system, ATP-binding protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0248HELNAPAPROT1493e-49 Helicobacter neutrophil-activating protein A family ...
		>HELNAPAPROT#Helicobacter neutrophil-activating protein A family

signature.
Length = 153

Score = 149 bits (377), Expect = 3e-49
Identities = 39/140 (27%), Positives = 74/140 (52%), Gaps = 1/140 (0%)

Query: 5 EILKHLQADAIVLFMKVHNFHWNVKGTDFFNVHKATEEIYEEFADMFDDLAERIAQLGHH 64
L ++ +L+ K+H FHW VKG FF +H+ EE+Y+ A+ D +AER+ +G
Sbjct: 15 NSLNTQLSNWFLLYSKLHRFHWYVKGPHFFTLHEKFEELYDHAAETVDTIAERLLAIGGQ 74

Query: 65 PLVTLSEALKLTRVKEETKTSFHSKDIFKEILGDYKHLEKEFKELSNTAEKEGDKVTVTY 124
P+ T+ E + + + + + ++ + ++ DYK + E K + AE+ D T
Sbjct: 75 PVATVKEYTEHASITDGGNET-SASEMVQALVNDYKQISSESKFVIGLAEENQDNATADL 133

Query: 125 ADDQLAKLQKSIWMLEAHLA 144
+ +++K +WML ++L
Sbjct: 134 FVGLIEEVEKQVWMLSSYLG 153


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0249PF06580300.014 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 30.2 bits (68), Expect = 0.014
Identities = 10/71 (14%), Positives = 25/71 (35%), Gaps = 13/71 (18%)

Query: 281 IVLQNFLYNAIDAIEALEESEQ-GQVKIEAFIQNEFIVFTIIDNGKEVENKSALFEPFET 339
+++Q + N I + + Q G++ ++ N + + + G +
Sbjct: 258 MLVQTLVENGI--KHGIAQLPQGGKILLKGTKDNGTVTLEVENTGSLALKNTK------- 308

Query: 340 TKLKGNGLGLA 350
+ G GL
Sbjct: 309 ---ESTGTGLQ 316


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0251FLGPRINGFLGI362e-127 Flagellar P-ring protein signature.
		>FLGPRINGFLGI#Flagellar P-ring protein signature.

Length = 373

Score = 362 bits (931), Expect = e-127
Identities = 116/345 (33%), Positives = 190/345 (55%), Gaps = 26/345 (7%)

Query: 19 AEKIGDIASVVGVRDNQLIGYGLVIGLNGTGDK-SGSKFTMQSISNMLESVNVKISADDI 77
+I DIAS+ RDNQLIGYGLV+GL GTGD S FT QS+ ML+++ +
Sbjct: 28 TSRIKDIASLQAGRDNQLIGYGLVVGLQGTGDSLRSSPFTEQSMRAMLQNLGITTQGGQS 87

Query: 78 KSKNVAAVMITASLPPFARQGDKIDIHISSIGDAKSIQGGTLVMTPLNAVDGNIYALAQG 137
+KN+AAVM+TA+LPPFA G ++D+ +SS+GDA S++GG L+MT L+ DG IYA+AQG
Sbjct: 88 NAKNIAAVMVTANLPPFASPGSRVDVTVSSLGDATSLRGGNLIMTSLSGADGQIYAVAQG 147

Query: 138 AIVSGN-----------SNNLLSANIINGATIEREVSYDLFHKNAMTLSLKSPNFKNAIQ 186
A++ SA + NGA IERE+ + L L++P+F A++
Sbjct: 148 ALIVNGFSAQGDAATLTQGVTTSARVPNGAIIERELPSKFKDSVNLVLQLRNPDFSTAVR 207

Query: 187 VQNTLNKV----FGNKVAIALDPKTIQITRPERLSMVEFLALVQEIPINYSAKNKIIVDE 242
V + +N +G+ +A D + I + +P + +A ++ + + K++++E
Sbjct: 208 VADVVNAFARARYGDPIAEPRDSQEIAVQKPRVADLTRLMAEIENLTVETDTPAKVVINE 267

Query: 243 KSGTIVSGVDIIVHPIVVTSQDITLKITKEP--------LNDSKNTQDLDNNMSLDTAHN 294
++GTIV G D+ + + V+ +T+++T+ P Q + M++
Sbjct: 268 RTGTIVIGADVRISRVAVSYGTLTVQVTESPQVIQPAPFSRGQTAVQPQTDIMAMQEGSK 327

Query: 295 TLSSNGKSITIAGVVKALQKIGVSAKGMVSILQALKKSGAISAEM 339
G + +V L IG+ A G+++ILQ +K +GA+ AE+
Sbjct: 328 VAIVEGPDLR--TLVAGLNSIGLKADGIIAILQGIKSAGALQAEL 370


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0252SECA290.049 SecA protein signature.
		>SECA#SecA protein signature.

Length = 901

Score = 29.1 bits (65), Expect = 0.049
Identities = 16/63 (25%), Positives = 31/63 (49%), Gaps = 2/63 (3%)

Query: 261 IVFTRTKKEADELHQFLASKNYKSTALHGDMDQRDRRSSIMAFKKNDADVLVATDVASRG 320
+V T + ++++ + L K L+ + ++I+A A V +AT++A RG
Sbjct: 453 LVGTISIEKSELVSNELTKAGIKHNVLNAKFHANE--AAIVAQAGYPAAVTIATNMAGRG 510

Query: 321 LDI 323
DI
Sbjct: 511 TDI 513


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0255HTHFIS320.004 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 32.5 bits (74), Expect = 0.004
Identities = 16/50 (32%), Positives = 21/50 (42%), Gaps = 7/50 (14%)

Query: 30 VAIVGESGSGKSSIANLIMRLNPR----FKPHNGEVLFETTNLLKESEAF 75
+ I GESG+GK +A + R F N + L ESE F
Sbjct: 163 LMITGESGTGKELVARALHDYGKRRNGPFVAINMAAIPRD---LIESELF 209


20HELPY_0324HELPY_0329N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_0324015-1.182347Guanylate kinase (GMP kinase)
HELPY_0325014-1.495109Conserved hypothetical protein; poly E-rich
HELPY_0326-114-2.059112Putative phospholipase D family protein;
HELPY_0327114-1.914075Outer membrane protein HorC; putative signal
HELPY_0328216-2.245457Flagellar L-ring protein precursor (Basal body
HELPY_0329215-2.095984Putative flagellar biosynthesis protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0324PF05272290.011 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 29.3 bits (65), Expect = 0.011
Identities = 9/18 (50%), Positives = 11/18 (61%)

Query: 8 LILSGPSGAGKSTLTKYL 25
++L G G GKSTL L
Sbjct: 599 VVLEGTGGIGKSTLINTL 616


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0325IGASERPTASE648e-13 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 63.9 bits (155), Expect = 8e-13
Identities = 51/275 (18%), Positives = 88/275 (32%), Gaps = 25/275 (9%)

Query: 148 EALAKEEPNNEEQLLPTLDAQEEKEEVKETPQKEEKPKDDETQESETPKDEEVSKELETQ 207
E +A+ + P + E E V E ++E K + Q++ + +
Sbjct: 1015 EEIARVDEAPVPPPAPATPS-ETTETVAENSKQESKTVEKNEQDATETT-------AQNR 1066

Query: 208 ENKEEKQEETQDSPSAQELEAMQELVKEIQENSNGQEDKKETQESAEISQDKEIQEVVTE 267
E +E + + + E+ KE Q + KET + + K E E
Sbjct: 1067 EVAKEAKSNVKANTQTNEVAQSGSETKETQT-----TETKETATVEKEEKAKVETEKTQE 1121

Query: 268 KTQVQELEVPK----EKTQESAEALQE----TQAHELEKQENTETPQEKEKQEIAETPQE 319
+V PK E Q AE +E E + Q NT E+ +E + ++
Sbjct: 1122 VPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQTNTTADTEQPAKETSSNVEQ 1181

Query: 320 --KEKQEIAETPQEKETPQEETQETQEVVTEQTQEDHYENIEDIPEPVMAKAMGEELPFL 377
E + E P+ T T + E + V + E
Sbjct: 1182 PVTESTTVNTGNSVVENPENTTPATTQ--PTVNSESSNKPKNRHRRSVRSVPHNVEPATT 1239

Query: 378 NESVAETPNSENATETPQEKEESDKTSSPLELRLN 412
+ + T + T T SD + + LN
Sbjct: 1240 SSNDRSTVALCDLTSTNTNAVLSDARAKAQFVALN 1274



Score = 60.8 bits (147), Expect = 6e-12
Identities = 47/264 (17%), Positives = 97/264 (36%), Gaps = 15/264 (5%)

Query: 178 PQKEEKPKDDETQESETPKDEEVSKELETQENKE-EKQEETQDSPSAQELEAMQELVKEI 236
P+ E++ + +T TP + + N+E + +E P A +
Sbjct: 983 PEVEKRNQTVDTTNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVAE 1042

Query: 237 QENSNGQEDKKETQESAEISQDKEIQEVVTEKTQVQELEVPKEKTQESAEALQETQAHEL 296
+ +K Q++ E + +EV E + + +S +ETQ E
Sbjct: 1043 NSKQESKTVEKNEQDATETTAQN--REVAKEAKSNVKANTQTNEVAQSGSETKETQTTE- 1099

Query: 297 EKQENTETPQEKEKQEIAETPQEKEKQEIAETPQEKETPQEETQETQEVVTEQTQEDHYE 356
T+ EK+E A+ E + QE+ + + QE+++ Q + D
Sbjct: 1100 -----TKETATVEKEEKAKVETE-KTQEVPKVTSQVSPKQEQSETVQPQAEPARENDPTV 1153

Query: 357 NIEDIPEPVMAKAMGEELPFLNESVAETPNSENATET-----PQEKEESDKTSSPLELRL 411
NI++ A E+ S E P +E+ T + E + ++ +
Sbjct: 1154 NIKEPQSQTNTTADTEQPAKETSSNVEQPVTESTTVNTGNSVVENPENTTPATTQPTVNS 1213

Query: 412 NLQDLLKSLNQESLKSLLENKTLS 435
+ K+ ++ S++S+ N +
Sbjct: 1214 ESSNKPKNRHRRSVRSVPHNVEPA 1237



Score = 54.3 bits (130), Expect = 7e-10
Identities = 35/253 (13%), Positives = 77/253 (30%), Gaps = 6/253 (2%)

Query: 99 KPFLPTEMLKVLQKKLGSDMSELEPSQN--LDPTQEVLETNWDELENLGDLEALAKEEPN 156
++ + S+ E+ + P + E + E N
Sbjct: 995 TNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVAENSKQESKTVEKN 1054

Query: 157 NEEQLLPTLDAQEEKEEVKETPQKEEKPKDDETQESETPKDEEVSKELETQENKEEKQ-- 214
++ T +E +E K + + + SET + + + KEEK
Sbjct: 1055 EQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETKETATVEKEEKAKV 1114

Query: 215 --EETQDSPSAQELEAMQELVKEIQENSNGQEDKKETQESAEISQDKEIQEVVTEKTQVQ 272
E+TQ+ P + ++ E + + + + + Q + TE+ +
Sbjct: 1115 ETEKTQEVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQTNTTADTEQPAKE 1174

Query: 273 ELEVPKEKTQESAEALQETQAHELEKQENTETPQEKEKQEIAETPQEKEKQEIAETPQEK 332
++ ES E + T Q E + P+ + ++ + P
Sbjct: 1175 TSSNVEQPVTESTTVNTGNSVVENPENTTPATTQPTVNSESSNKPKNRHRRSVRSVPHNV 1234

Query: 333 ETPQEETQETQEV 345
E + + V
Sbjct: 1235 EPATTSSNDRSTV 1247


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0328FLGLRINGFLGH1913e-63 Flagellar L-ring protein signature.
		>FLGLRINGFLGH#Flagellar L-ring protein signature.

Length = 232

Score = 191 bits (486), Expect = 3e-63
Identities = 51/172 (29%), Positives = 84/172 (48%), Gaps = 18/172 (10%)

Query: 56 GERPLFADRRAMKPNDLITIIVSEKASANYSSS----KDYKSASGGNSTPPRLTYNGLDE 111
G +PLF DRR D +TI++ E SA+ SSS +D K+ G ++ P L GL
Sbjct: 61 GYQPLFEDRRPRNIGDTLTIVLQENVSASKSSSANASRDGKTNFGFDTVPRYL--QGLFG 118

Query: 112 RKKQEAQYLDDKNNYNFTKSSNNTNFKGGGSQKKSEDLEIVLSARIIKVLENGNYFIYGN 171
+ + + S F G G S L+ + +VL NGN + G
Sbjct: 119 NARADVEA------------SGGNTFNGKGGANASNTFSGTLTVTVDQVLVNGNLHVVGE 166

Query: 172 KEVLVDGEKQILKVSGVIRPYDIERNNTIQSKFLADAKIEYTNLGHLSDSNK 223
K++ ++ + ++ SGV+ P I +NT+ S +ADA+IEY G+++++
Sbjct: 167 KQIAINQGTEFIRFSGVVNPRTISGSNTVPSTQVADARIEYVGNGYINEAQN 218


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0331SACTRNSFRASE280.020 Streptothricin acetyltransferase signature.
		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

Length = 173

Score = 27.6 bits (61), Expect = 0.020
Identities = 14/49 (28%), Positives = 21/49 (42%), Gaps = 3/49 (6%)

Query: 102 KGETILKALECIAFE---EFQLHSLHLEVMENNFKAIAFYEKNHYELEG 147
+ + + AL A E E L LE + N A FY K+H+ +
Sbjct: 102 RKKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGA 150


21HELPY_0346HELPY_0355N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_03460130.241447Flagellar M-ring protein
HELPY_0347-1100.820236Flagellar motor switch protein
HELPY_03480100.549553Flagellar export protein
HELPY_0349-190.4827661-deoxy-D-xylulose-5-phosphate synthase
HELPY_0350-290.836567GTP-binding protein LepA
HELPY_0351-2100.496161Conserved hypothetical protein
HELPY_0352-2101.210592Conserved hypothetical protein
HELPY_0353-281.124526Flagellar basal-body rod protein FlgG (Distal
HELPY_0354-3100.675591General substrate transporter, MFS superfamily;
HELPY_0355-3100.828181DNA translocase FtsK; putative membrane protein;
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0354FLGMRINGFLIF5580.0 Flagellar M-ring protein signature.
		>FLGMRINGFLIF#Flagellar M-ring protein signature.

Length = 559

Score = 558 bits (1440), Expect = 0.0
Identities = 178/582 (30%), Positives = 294/582 (50%), Gaps = 66/582 (11%)

Query: 11 VDFFIKLNKKQKIALIAAGVLITALLVFLLLYPFKEKDYTQGGYGVLFEGLDSSDNALIL 70
+++ +L +I LI AG A++V ++L+ K DY LF L D I+
Sbjct: 13 LEWLNRLRANPRIPLIVAGSAAVAIVVAMVLWA-KTPDYR-----TLFSNLSDQDGGAIV 66

Query: 71 QHLQQNQIPYKVSKDD-TILIPKDKVYEERITLASQGIPKTSKVGFEIFDTKDFGATDFD 129
L Q IPY+ + I +P DKV+E R+ LA QG+PK VGFE+ D + FG + F
Sbjct: 67 AQLTQMNIPYRFANGSGAIEVPADKVHELRLRLAQQGLPKGGAVGFELLDQEKFGISQFS 126

Query: 130 QNIKLIRAIEGELSRTIESLNPILKANVHIAIPKDSVFVAKEVPPSASVMLKLKPDMKLS 189
+ + RA+EGEL+RTIE+L P+ A VH+A+PK S+FV ++ PSASV + L+P L
Sbjct: 127 EQVNYQRALEGELARTIETLGPVKSARVHLAMPKPSLFVREQKSPSASVTVTLEPGRALD 186

Query: 190 PTQILGIKNLIAAAVPKLTIDNVKIVNENGESIGEGDILENSKELALEQLHYKQNFENIL 249
QI + +L+++AV L NV +V+++G + + + + ++L QL + + E+ +
Sbjct: 187 EGQISAVVHLVSSAVAGLPPGNVTLVDQSGHLLTQSNT--SGRDLNDAQLKFANDVESRI 244

Query: 250 ENKIVNILAPIVGGKNKVVARVNAEFDFSQKKSTKETFDPNN-----VVRSEQNLEEKKE 304
+ +I IL+PIVG N V A+V A+ DF+ K+ T+E + PN +RS Q ++
Sbjct: 245 QRRIEAILSPIVGNGN-VHAQVTAQLDFANKEQTEEHYSPNGDASKATLRSRQLNISEQV 303

Query: 305 GAPKKQVGGVPGVVSN-IGPVQGLKDNKEPEKYEKSQN---------------------- 341
GA GGVPG +SN P P + +QN
Sbjct: 304 GAGYP--GGVPGALSNQPAPPNEAPIATPPTNQQNAQNTPQTSTSTNSNSAGPRSTQRNE 361

Query: 342 TTNYEVGKTISEIKGEFGTLVRLNAAVVVDGKYKIALKDGANTLEYEPLSDESLQKINAL 401
T+NYEV +TI K G + RL+ AVVV+ K L DG + PL+ + +++I L
Sbjct: 362 TSNYEVDRTIRHTKMNVGDIERLSVAVVVNYK---TLADG----KPLPLTADQMKQIEDL 414

Query: 402 VKQAIGYNQNRGDDVAVSNFEFNPMAPMIDNATLSEKIMHKTQKILGSFTPLIKYVLVFI 461
++A+G++ RGD + V N F+ + T E + Q + +++LV +
Sbjct: 415 TREAMGFSDKRGDTLNVVNSPFSAVDN-----TGGELPFWQQQSFIDQLLAAGRWLLVLV 469

Query: 462 VLFIFYKKVIVPFSERMLEVVPDEDKEVKSMFEEMDEEEDELNKLGDLRKKVEDQLGLNA 521
V +I ++K + P R +E ++ + E + E L+K L+++ +Q
Sbjct: 470 VAWILWRKAVRPQLTRRVEEAKAAQEQAQVRQETEEAVEVRLSKDEQLQQRRANQ----- 524

Query: 522 TFSEEEVRYEIILEKIRGTLKERPDEIATLFKLLIKDEISSD 563
+ E++ ++IR E D + L+I+ +S+D
Sbjct: 525 -----RLGAEVMSQRIR----EMSDNDPRVVALVIRQWMSND 557


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0355FLGMOTORFLIG348e-122 Flagellar motor switch protein FliG signature.
		>FLGMOTORFLIG#Flagellar motor switch protein FliG signature.

Length = 344

Score = 348 bits (895), Expect = e-122
Identities = 121/338 (35%), Positives = 208/338 (61%), Gaps = 4/338 (1%)

Query: 8 KQKAQLDELSMSEKIAILLIQVGEDTTGEILRHLDIDSITEISKQIVQLNGTDKQIGAAV 67
K+ + L+ +K AILL+ +G + + ++ ++L + I ++ +I +L ++ V
Sbjct: 7 KEILDVSALTGKQKAAILLVSIGSEISSKVFKYLSQEEIESLTFEIAKLETITSELKDNV 66

Query: 68 LEEFFAIFQSNQYINTGGLEYARELLTRTLGSEEARKVMDKLTKSLQTQKNFAYLGKIKP 127
L EF + + ++I GG++YARELL ++LG+++A +++ L +LQ+ + F ++ + P
Sbjct: 67 LLEFKELMMAQEFIQKGGIDYARELLEKSLGTQKAVDIINNLGSALQS-RPFEFVRRADP 125

Query: 128 QQLADFIINEHPQTIALILAHMEAPNAAETLSYFPDEMKAEISIRMANLGEISPQVVKRV 187
+ +FI EHPQTIALIL++++ A+ LS P E++ ++ R+A + SP+VV+ V
Sbjct: 126 ANILNFIQQEHPQTIALILSYLDPQKASFILSSLPTEVQTNVARRIALMDRTSPEVVREV 185

Query: 188 STVLENKLESLTSYK-IEVGGLRAVAEIFNRLGQKSAKTTLARIESVDNKLAGAIKEMMF 246
VLE KL SL+S GG+ V EI N +K+ K + +E D +LA IK+ MF
Sbjct: 186 ERVLEKKLASLSSEDYTSAGGVDNVVEIINMADRKTEKFIIESLEEEDPELAEEIKKKMF 245

Query: 247 TFEDIAKLDNFAIREILKVADKKDLSLALKTSTQDLTDKFLNNMSSRAAEQFVEEMQYLG 306
FEDI LD+ +I+ +L+ D ++L+ ALK+ + +K NMS RAA E+M++LG
Sbjct: 246 VFEDIVLLDDRSIQRVLREIDGQELAKALKSVDIPVQEKIFKNMSKRAASMLKEDMEFLG 305

Query: 307 AVKIKDVDVAQRKIIEIVQSLQEKG--VIQTGEEEDVI 342
+ KDV+ +Q+KI+ +++ L+E+G VI G EEDV+
Sbjct: 306 PTRRKDVEESQQKIVSLIRKLEEQGEIVISRGGEEDVL 343



Score = 31.3 bits (71), Expect = 0.006
Identities = 20/103 (19%), Positives = 41/103 (39%), Gaps = 3/103 (2%)

Query: 4 KLTPKQKAQLDELSMSEKIAILLIQVGEDTTGEILRHLDIDSITEISKQIVQLNGTDKQI 63
+ P + + IA++L + IL L + T ++++I ++ T ++
Sbjct: 122 RADPANILNFIQQEHPQTIALILSYLDPQKASFILSSLPTEVQTNVARRIALMDRTSPEV 181

Query: 64 GAA---VLEEFFAIFQSNQYINTGGLEYARELLTRTLGSEEAR 103
VLE+ A S Y + GG++ E++ E
Sbjct: 182 VREVERVLEKKLASLSSEDYTSAGGVDNVVEIINMADRKTEKF 224


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0356FLGFLIH373e-05 Flagellar assembly protein FliH signature.
		>FLGFLIH#Flagellar assembly protein FliH signature.

Length = 228

Score = 37.5 bits (86), Expect = 3e-05
Identities = 45/207 (21%), Positives = 91/207 (43%), Gaps = 14/207 (6%)

Query: 49 PLEKKAIENDLIDCLLKKTDELSSHLVKLQMQFEKAQEES-KALIENAKNDGYKIGFKEG 107
E I + + L L +LQMQ A E+ +A I + G+K G++EG
Sbjct: 19 QAEFVPIVEPEETIIEEAEPSLEQQLAQLQMQ---AHEQGYQAGIAEGRQQGHKQGYQEG 75

Query: 108 EEKMRNELTHSVNEEKNQLLHAITALDEKMKKSQDHLMALE----KELSAIAIDIAKEVI 163
+ L + E K+Q + + + + Q L AL+ L +A++ A++VI
Sbjct: 76 ---LAQGLEQGLAEAKSQQAPIHARMQQLVSEFQTTLDALDSVIASRLMQMALEAARQVI 132

Query: 164 LKEVEDNSQKVALALAEELLKNVLDATDIHLKVNPLDYPYLNERLQNASKI---KLESNE 220
+ ++ + + + L + L + L+V+P D +++ L + +L +
Sbjct: 133 GQTPTVDNSALIKQIQQLLQQEPLFSGKPQLRVHPDDLQRVDDMLGATLSLHGWRLRGDP 192

Query: 221 AISKGGVMITSSNGSLDGNLMERFKTL 247
+ GG +++ G LD ++ R++ L
Sbjct: 193 TLHPGGCKVSADEGDLDASVATRWQEL 219


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0358TCRTETOQM1148e-29 Tetracycline resistance protein TetO/TetQ/TetM family ...
		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

signature.
Length = 639

Score = 114 bits (287), Expect = 8e-29
Identities = 54/162 (33%), Positives = 89/162 (54%), Gaps = 7/162 (4%)

Query: 9 NIRNFSIIAHIDHGKSTLADCLIAECNAIS---NREMKSQVMDTMDIEKERGITIKAQSV 65
I N ++AH+D GK+TL + L+ AI+ + + + D +E++RGITI+
Sbjct: 2 KIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGIT 61

Query: 66 RLNYTFKGEDYVLNLIDTPGHVDFSYEVSRSLCSCEGALLVVDATQGVEAQTIANTYIAL 125
+F+ E+ +N+IDTPGH+DF EV RSL +GA+L++ A GV+AQT +
Sbjct: 62 ----SFQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALR 117

Query: 126 DNNLEILPVINKIDLPNANVLEVKQDIEDTIGIDCSNANEVS 167
+ + INKID ++ V QDI++ + + +V
Sbjct: 118 KMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVE 159



Score = 84.1 bits (208), Expect = 5e-19
Identities = 50/215 (23%), Positives = 90/215 (41%), Gaps = 17/215 (7%)

Query: 167 SAKAKLGIKDLLEKIITTIPAPSGDPNAPLKALIYDSWFDNYLGALALVRIMDGSINTEQ 226
SAK +GI +L+E I + + + L ++ + LA +R+ G ++
Sbjct: 220 SAKNNIGIDNLIEVITNKFYSSTHRGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLHLRD 279

Query: 227 EILVMGTGKKHGVLGLYYPNPLKKIPTKSLECGEIGIV---SLGLKSVTDIAVGDTLTDA 283
+ + K + +Y + GEI I+ L L SV +GDT
Sbjct: 280 SVRISEKEKI-KITEMYTSINGELCKIDKAYSGEIVILQNEFLKLNSV----LGDTKLL- 333

Query: 284 KNPTSKPIEGFMPAKPFVFAGLYPIETDRFEDLREALLKLQLNDCALNFEPESSVALGFG 343
P + IE P + + P + + E L +ALL++ +D L + +S+
Sbjct: 334 --PQRERIEN---PLPLLQTTVEPSKPQQREMLLDALLEISDSDPLLRYYVDSATH---E 385

Query: 344 FRVGFLGLLHMEVIKERLEREFGLNLIATAPTVVY 378
+ FLG + MEV L+ ++ + + PTV+Y
Sbjct: 386 IILSFLGKVQMEVTCALLQEKYHVEIEIKEPTVIY 420



Score = 31.0 bits (70), Expect = 0.015
Identities = 15/75 (20%), Positives = 28/75 (37%), Gaps = 2/75 (2%)

Query: 405 IKEPFVRATIITPSEFLGNLMQLLNNKRGIQEKMEYLNQSRVMLTYSLPSNEIVMDFYDK 464
+ EP++ I P E+L + L + V+L+ +P+ I ++
Sbjct: 535 LLEPYLSFKIYAPQEYLSRAYTDAPKYCANIVDTQ-LKNNEVILSGEIPARCI-QEYRSD 592

Query: 465 LKSCTKGYASFDYEP 479
L T G + E
Sbjct: 593 LTFFTNGRSVCLTEL 607


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0361FLGHOOKAP1300.009 Flagellar hook-associated protein signature.
		>FLGHOOKAP1#Flagellar hook-associated protein signature.

Length = 546

Score = 30.3 bits (68), Expect = 0.009
Identities = 9/40 (22%), Positives = 16/40 (40%)

Query: 3 NGYYAATGAMATQFNRLDLTSNNLANLNTNGFKRDDAITG 42
+ A + L+ SNN+++ N G+ R I
Sbjct: 2 SLINNAMSGLNAAQAALNTASNNISSYNVAGYTRQTTIMA 41


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0362TCRTETB392e-05 Tetracycline resistance protein TetB signature.
		>TCRTETB#Tetracycline resistance protein TetB signature.

Length = 458

Score = 39.1 bits (91), Expect = 2e-05
Identities = 59/308 (19%), Positives = 105/308 (34%), Gaps = 53/308 (17%)

Query: 37 APYFAKEFTHTNDPTLALISAFLVFMLGFFMRPLGSLFFGKLGDKKGRKTSMVYSIILMA 96
P A +F T + +AF++ G+ +GKL D+ G K +++ II+
Sbjct: 37 LPDIANDFNKPPASTNWVNTAFMLTFSI------GTAVYGKLSDQLGIKRLLLFGIIINC 90

Query: 97 LGSFMLALLPTKEIVGEWAFLFLLLARLLQGFSVGGE------YGVVATYLSELGKNGKK 150
GS + VG F L++AR +QG G VVA Y+ + +
Sbjct: 91 FGSVIGF-------VGHSFFSLLIMARFIQG--AGAAAFPALVMVVVARYIPKENRGKAF 141

Query: 151 GFYGSFQYVTLVGGQLLAIFSLFIVENIYTHEQISAFAWRYLFALGGILALLSLFLRNIM 210
G GS + +G + I I+ W YL + I + FL ++
Sbjct: 142 GLIGS---IVAMGEGVGPAIGGMIAHYIH---------WSYLLLIPMITIITVPFLMKLL 189

Query: 211 EETMDSKTTSKTTIKEETQRGSLKELLHHKKALMIVFGLTMGGSLCFYTFTVYLKIFLTN 270
++ + + IK +L + + T + IF+ +
Sbjct: 190 KK--EVRIKGHFDIK--------GIILMSVGIVFFMLFTTSYSISFLIVSVLSFLIFVKH 239

Query: 271 SSSFSPK-------ESSFIMLLALSYFIFLQPLCG---MLADKIKRTQMLMVFAIAGLIV 320
+ ++ M+ L I + G M+ +K L I +I+
Sbjct: 240 IRKVTDPFVDPGLGKNIPFMIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVII 299

Query: 321 TPVVFYGI 328
P I
Sbjct: 300 FPGTMSVI 307


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0363IGASERPTASE350.001 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 35.4 bits (81), Expect = 0.001
Identities = 51/245 (20%), Positives = 88/245 (35%), Gaps = 31/245 (12%)

Query: 169 FSPKKEGFENTLSDLQKKETNNDKEKENRKENPIDENHKTPNKESFLAIPTPY------N 222
++P+ E T+ D T N+ + + P + E+ + P P
Sbjct: 981 YNPEVEKRNQTV-DTTNITTPNNIQADVPSV-PSNNEEIARVDEAPVPPPAPATPSETTE 1038

Query: 223 TTLNDLKPQEGLVQISSHPPTHYTI----YPKKNRFDDLSNPTNPTLKEPKQETKEREPM 278
T + K + V+ + T T K+ + + +N + + ETKE +
Sbjct: 1039 TVAENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTT 1098

Query: 279 LKKETPTTLKPIMPISAPNLENDNKTENHKTPNHPIKGDNL----QESPQENPQKENQKE 334
KET T K E K E KT P + ++S PQ E +E
Sbjct: 1099 ETKETATVEK----------EEKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEPARE 1148

Query: 335 NIEEKENLKEEKRETENAPSFSPLTPTSAKKPVMVKELSENKEILDGLDYGEVEKPKDYE 394
N + N+KE + +T P + + ++E+ + G VE P++
Sbjct: 1149 N-DPTVNIKEPQSQTNTTADTE--QPAKETSSNVEQPVTESTTVNTGNSV--VENPENTT 1203

Query: 395 LPTTQ 399
TTQ
Sbjct: 1204 PATTQ 1208


22HELPY_0750HELPY_0756N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_0750-110-0.998160Chemotaxis protein
HELPY_0751-112-0.769098DNA ligase (NAD(+))
HELPY_0752-211-0.794339Conserved hypothetical protein
HELPY_0753-211-0.510479Putative vacuolating cytotoxin VacA-like;
HELPY_0754-212-0.942328Conserved hypothetical protein; putative
HELPY_0755-213-1.204731Cytoplasmic pump proteins of the hefABC efflux
HELPY_0756-217-2.284188Membrane fusion protein of the hefABC efflux
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0756HTHFIS564e-11 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 56.4 bits (136), Expect = 4e-11
Identities = 25/121 (20%), Positives = 53/121 (43%), Gaps = 7/121 (5%)

Query: 194 ILIAEDSLSALKTLEKIVQTLELRYLAFPNGRELLDYLYEKEHYQQVGVVITDLEMPNIS 253
IL+A+D + L + + N L ++ +V+TD+ MP+ +
Sbjct: 6 ILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAA----GDGDLVVTDVVMPDEN 61

Query: 254 GFEVLKTIKADHRTEHLPVIINSSMSSDSNRQLAQSLEADGFVVKS-NILEIHEMLRKTL 312
F++L IK LPV++ S+ ++ A A ++ K ++ E+ ++ + L
Sbjct: 62 AFDLLPRIKKAR--PDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRAL 119

Query: 313 S 313
+
Sbjct: 120 A 120


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0758LCRVANTIGEN315e-04 Low calcium response V antigen signature.
		>LCRVANTIGEN#Low calcium response V antigen signature.

Length = 326

Score = 31.2 bits (70), Expect = 5e-04
Identities = 16/33 (48%), Positives = 20/33 (60%)

Query: 16 KRKKLLTELAELEAEIKVSSERRSSFNISLSPS 48
R KL ELAEL AE+K+ S ++ N LS S
Sbjct: 149 ARSKLREELAELTAELKIYSVIQAEINKHLSSS 181


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0763VACCYTOTOXIN2811e-78 Helicobacter pylori vacuolating cytotoxin signature.
		>VACCYTOTOXIN#Helicobacter pylori vacuolating cytotoxin signature.

Length = 1291

Score = 281 bits (720), Expect = 1e-78
Identities = 106/397 (26%), Positives = 184/397 (46%), Gaps = 14/397 (3%)

Query: 2796 AGNNSILWLNELFVAKGGNPLFAPYYLQDTPTKHIVTLMEDVSSALGMLSKPNLKNNSTD 2855
+G L L + + +A + T I + ++ L ++ K +
Sbjct: 904 SGAQGRDLLQTLLI-DSHDAGYARTMIDATSANEITKQLNTATTTLNNIASLEHKTSGLQ 962

Query: 2856 ALQLNTYTQQMSRLAKLSNFASFDSTDFSERLSSLKNQRFADAIPNAMDVILKYSQRDKL 2915
L L+ SRL LS + F++RL +LK+QRFA + +A +V+ +++ + +
Sbjct: 963 TLSLSNAMILNSRLVNLSRRHTNHIDSFAKRLQALKDQRFAS-LESAAEVLYQFAPKYEK 1021

Query: 2916 KNNLWATGVGGVSFVENGTGTLYGVNVGYDRFIKG---VIVGGYVAYGYSGFYER--ITS 2970
N+WA +GG S G +LYG + G D ++ G IVGG+ +YGYS F + +
Sbjct: 1022 PTNVWANAIGGTSLNSGGNASLYGTSAGVDAYLNGEVEAIVGGFGSYGYSSFSNQANSLN 1081

Query: 2971 SKSDNVDVGLYARAFIKKSELTFSVNETWGANKTQINSNDTLLSMINQSYKYNTWTTNAK 3030
S ++N + G+Y+R F + E F G++++ +N LL +NQSY Y ++ +
Sbjct: 1082 SGANNTNFGVYSRIFANQHEFDFEAQGALGSDQSSLNFKSALLRDLNQSYNYLAYSAATR 1141

Query: 3031 VNYGYDFMFKNKSIILKPQIGLRYYYIGMTGLEGVMHNALYNQFKANADPSKKSVLTIDF 3090
+YGYDF F +++LKP +G+ Y ++G T + + S + +
Sbjct: 1142 ASYGYDFAFFRNALVLKPSVGVSYNHLGSTNFKS----NSNQKVALKNGASSQHLFNASA 1197

Query: 3091 ALENRHYFNTNSYFYAIGGVGRDLLVRSMGDKLVRFIGNNTLSYRKGELYNTFASITTGG 3150
+E R+Y+ SYFY GV ++ + V + R NT A + GG
Sbjct: 1198 NVEARYYYGDTSYFYMNAGVLQEFANFGSSNA-VSLNTFKVNATRNP--LNTHARVMMGG 1254

Query: 3151 EVRLFKSFYANAGVGARFGLDYKMINITGNIGMRLAF 3187
E++L K + N G L + + N+GMR +F
Sbjct: 1255 ELKLAKEVFLNLGFVYLHNLISNIGHFASNLGMRYSF 1291



Score = 34.6 bits (79), Expect = 0.009
Identities = 15/100 (15%), Positives = 31/100 (31%), Gaps = 5/100 (5%)

Query: 700 SYSFDGINNAFNEDKFNGGSFNFNHAEQTDAFNNNSFNGGSFNFNSKQVDFNHSSFNGGV 759
SYS + E FN + ++A Q +N + G+ + + N + G
Sbjct: 272 SYSTINTSKVTGEVNFNHLTVGDHNAAQAGIIASNKTHIGTLDLW-QSAGLNIIAPPEGG 330

Query: 760 FNF---NNTPKVSFTDDTFNVNNQFKING-AQTAFTFNKG 795
+ + + + + + N Q N
Sbjct: 331 YKDKPNDKPSNTTQNNAKNDKQESSQNNSNTQVINPPNSA 370



Score = 33.5 bits (76), Expect = 0.019
Identities = 85/472 (18%), Positives = 143/472 (30%), Gaps = 95/472 (20%)

Query: 82 SVNENNNNKSYYVSPLRTWAGGNRNFTQNYNNSQLYIGTKNASATPNNSSIWFGEKGYVG 141
V+ N +Y +S L + GG+ N + L +G N N+ + + K
Sbjct: 133 EVDMQNAVGTYNLSGLINFTGGD--LDVNMQKATLRLGQFNG----NSFTSY---KDSAD 183

Query: 142 FITGV-FKAKDIFITGAVGSGNEWKTGGGAILVFESLNELNTNGAYFQNNRAGT---QTS 197
T V F AK+I I + N +G G L L + A +
Sbjct: 184 RTTRVDFNAKNILIDNFLEINNRVGSGAGRKASSTVLT-LQASEGITSRENAEISLYDGA 242

Query: 198 WINLISNHSVNLTNTDFGNQTPNGGFNAMGRKITYNGGIVNGGNF-----GFDNMDSNGT 252
+NL SN + N G G + A + NF G N G
Sbjct: 243 TLNLASNSVKLMGNVWMGRLQYVGAYLAPSYSTINTSKVTGEVNFNHLTVGDHNAAQAGI 302

Query: 253 -----TTISGVTFNNNGALTY----KGGNGIGGSITFTNSNINHYKLNLNANSVTFNNST 303
T I + + L +GG + +N+ N+ K + +S +N+
Sbjct: 303 IASNKTHIGTLDLWQSAGLNIIAPPEGGYKDKPNDKPSNTTQNNAKNDKQESSQNNSNTQ 362

Query: 304 LGSMPN------------------GNANTIGNAYILNAN------NITFNNLTFNGGWFV 339
+ + PN G NT+ N +N N F +
Sbjct: 363 VINPPNSAQKTEIQPTQVIDGPFAGGKNTVVNINRINTNADGTIRVGGFKASLTTNAAHL 422

Query: 340 FDRSDAHVNFQGTTTINNPTSPFVNMTGKVTINPNAIFNIQ--NYTPSIGSAYTLFSM-- 395
+N + + N+TG +T++ N Q Y + SA F
Sbjct: 423 HIGKGG-INLSNQAS--GRSLLVENLTGNITVDGPLRVNNQVGGYALAGSSANFEFKAGT 479

Query: 396 --KNGSITYND------------------------VDNLWNIIRL----------KNTQA 419
KNG+ T+N+ + +N + K A
Sbjct: 480 DTKNGTATFNNDISLGRFVNLKVDAHTANFKGIDTGNGGFNTLDFSGVTNKVNINKLITA 539

Query: 420 TKDNSKNATSNNNTHTYYVTYNLGGTLYNFRQIFSPDSIVLQSVYYGANNIY 471
+ + + + N ++G + I S I + G +IY
Sbjct: 540 STNVAVKNFNINELVVKTNGVSVGEYTHFSEDIGSQSRINTVRLETGTRSIY 591


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0765ACRIFLAVINRP8940.0 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 894 bits (2311), Expect = 0.0
Identities = 287/1040 (27%), Positives = 518/1040 (49%), Gaps = 42/1040 (4%)

Query: 2 MYKTAINRPITTLMFALAIVFFGTMGFKKLSVALFPKIDMPTVVVTTTYPGASAEIIESK 61
M I RPI + A+ ++ G + +L VA +P I P V V+ YPGA A+ ++
Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60

Query: 62 VTDKIEEAVMGIDGIKKVTSTSSKNVSIVV-IEFELEKPNEEALNDVVNKISSVR-FDDS 119
VT IE+ + GID + ++STS S+ + + F+ + A V NK+
Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120

Query: 120 NIKKPSINKFDTDSQAIISLFVSSSSVPAT--TLNDYAKNTIKPMLQKINGVGGVQLNGF 177
+++ I+ + S ++ S + T ++DY + +K L ++NGVG VQL G
Sbjct: 121 EVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFG- 179

Query: 178 RERQIRIYADPTLMNKYNLTYADLFSTLKAENVEIDGGRIVNS------QRELSILINAN 231
+ +RI+ D L+NKY LT D+ + LK +N +I G++ + Q SI+
Sbjct: 180 AQYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTR 239

Query: 232 SYSVADVEKIQV-----GNHVRLGDIAKIEIGLEEDNTFASFKDKPGVILEIQKIAGANE 286
+ + K+ + G+ VRL D+A++E+G E N A KP L I+ GAN
Sbjct: 240 FKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANA 299

Query: 287 IEIVDRVYEALKHIQAISP-SYEIRPFLDTTSYIRTSIEDVKFDLVLGAILAVLVVFAFL 345
++ + L +Q P ++ DTT +++ SI +V L +L LV++ FL
Sbjct: 300 LDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFL 359

Query: 346 RNGTITLVSAISIPISIMGTFALIQWMGFSLNMLTMVALTLAIGIIIDDAIVVIENIHK- 404
+N TL+ I++P+ ++GTFA++ G+S+N LTM + LAIG+++DDAIVV+EN+ +
Sbjct: 360 QNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERV 419

Query: 405 KLEMGMSKRKASYEGVREIGFALVAISAMLLSVFVPIGNMKGIIGRFFQSFGITVALAIA 464
+E + ++A+ + + +I ALV I+ +L +VF+P+ G G ++ F IT+ A+A
Sbjct: 420 MMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMA 479

Query: 465 LSYVVVVTIIPMVSSVVVNPRHS-------RFYVWSEPFFKVLESRYTRLLQWVLNHKLI 517
LS +V + + P + + ++ P + F+ W F + YT + +L
Sbjct: 480 LSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGR 539

Query: 518 ISIAVVLVFVGSLFVASKLGMDFMLKEDRGRFLVWLKAKPGVSIDY----MTQKSKIFQK 573
+ L+ G + + +L F+ +ED+G FL ++ G + + + Q + + K
Sbjct: 540 YLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYLK 599

Query: 574 AIEKHDEVEFTTLQVGY-GTTQNPFKAKIFVQLKPLKERKKEGELGQFELMSVLRKELRS 632
+ + E FT + G QN FV LKP +ER + + + + EL
Sbjct: 600 NEKANVESVFTVNGFSFSGQAQNA--GMAFVSLKPWEERNGDENSAEAVIHR-AKMELGK 656

Query: 633 LPEAKGLDTINLSEVALIGGGGDSSPFQTFVFSHSQEAVDKSVENLKKFLLESPELKGKV 692
+ + + N+ + G ++ F + + D + + L + + +
Sbjct: 657 IRDGFVI-PFNMPAIV---ELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASL 712

Query: 693 ESYHTSTSESQPQLQLKILRQNANKYGVSAQTIGSVVSSAFSGTSQASVFKEDGKEYDMI 752
S + E Q +L++ ++ A GVS I +S+A G + + F + G+ +
Sbjct: 713 VSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGG-TYVNDFIDRGRVKKLY 771

Query: 753 IRVPDDKRVSVEDIKRLQVRNKYDKLMFLDALVEITETKSPSSISRYNRQRSVTVLAEPN 812
++ R+ ED+ +L VR+ +++ A + RYN S+ + E
Sbjct: 772 VQADAKFRMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEA- 830

Query: 813 RNAGVSLGEILTQVSKNTKEWLVEGANYRFTGEADNAKESNGEFLVALATAFVLIYMILA 872
G S G+ + + +N L G Y +TG + + S + +A +FV++++ LA
Sbjct: 831 -APGTSSGDAMALM-ENLASKLPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLA 888

Query: 873 ALYESILEPFIIMVTMPLSFSGAFFALGLVHQPLSMFSMIGLILLIGMVGKNATLLIDVA 932
ALYES P +M+ +PL G A L +Q ++ M+GL+ IG+ KNA L+++ A
Sbjct: 889 ALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFA 948

Query: 933 NE-ERKKGLNIQEAILFAGKTRLRPILMTTIAMVCGMLPLALASGDGAAMKSPIGIAMSG 991
+ K+G + EA L A + RLRPILMT++A + G+LPLA+++G G+ ++ +GI + G
Sbjct: 949 KDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMG 1008

Query: 992 GLMISMVLSLLIVPVFYRLL 1011
G++ + +L++ VPVF+ ++
Sbjct: 1009 GMVSATLLAIFFVPVFFVVI 1028


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0766RTXTOXIND502e-09 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 50.2 bits (120), Expect = 2e-09
Identities = 22/69 (31%), Positives = 34/69 (49%)

Query: 40 STGIVDSIKVTEGSVVKKGDVLLLLYNQDKQAQSDSTEQQLIFAKKQYQRYSKIGGAVDK 99
IV I V EG V+KGDVLL L +A + T+ L+ A+ + RY + +++
Sbjct: 103 ENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIEL 162

Query: 100 NTLEGYEFT 108
N L +
Sbjct: 163 NKLPELKLP 171



Score = 30.2 bits (68), Expect = 0.006
Identities = 18/115 (15%), Positives = 40/115 (34%), Gaps = 13/115 (11%)

Query: 70 QAQSDSTEQQLIFAKKQYQR--YSKIGGAVDKNTLEGYEFTYRRLESDYAYSIAVLNKTI 127
+++ S +++ + ++ K+ D L L + A + ++
Sbjct: 279 ESEILSAKEEYQLVTQLFKNEILDKLRQTTDNIGL---------LTLELAKNEERQQASV 329

Query: 128 LRAPFDGVIASKNIQVGEGVSANNTVLLRLVSHARKLVIE--FDSKYINAVKVGD 180
+RAP + + GV L+ +V L + +K I + VG
Sbjct: 330 IRAPVSVKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQ 384


23HELPY_0782HELPY_0788N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_0782080.685969Endonuclease III (DNA-(apurinic or apyrimidinic
HELPY_0783112-0.717911Flagellar motor switch protein fliN
HELPY_0784112-0.888677Conserved hypothetical protein; putative signal
HELPY_0785-112-1.373881Putative siderophore-mediated iron transport
HELPY_0786-114-2.722670Dihydroorotase (DHOase)
HELPY_0787-214-3.353858Conserved hypothetical protein; putative signal
HELPY_0788117-3.048352Conserved hypothetical protein; putative
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0790OMS28PORIN280.033 OMS28 porin signature.
		>OMS28PORIN#OMS28 porin signature.

Length = 257

Score = 27.8 bits (61), Expect = 0.033
Identities = 28/112 (25%), Positives = 53/112 (47%), Gaps = 11/112 (9%)

Query: 25 NQTTELHHKNPYELLVATILSAQCTDARVNQITPKLFEKYPSVNDLAL-----ASLEEVK 79
N+ E+ K E A ++ + T QI + K P+ +L L A +E+VK
Sbjct: 132 NKVVEMSKKAVQETQKAVSVAGEATFLIEKQI---MLNKSPNNKELELTKEEFAKVEQVK 188

Query: 80 EIIKSVSYFNNKSKHLISMAQKVVRDFKGVIPSTQKELMSLDGVGQKTANVV 131
E + + +++ + AQKV+ G+ PS + ++++ V + +NVV
Sbjct: 189 ETLMASERALDET---VQEAQKVLNMVNGLNPSNKDQVLAKKDVAKAISNVV 237


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0791FLGMOTORFLIN1001e-30 Flagellar motor switch protein FliN signature.
		>FLGMOTORFLIN#Flagellar motor switch protein FliN signature.

Length = 137

Score = 100 bits (250), Expect = 1e-30
Identities = 25/77 (32%), Positives = 47/77 (61%)

Query: 34 LICDYKNLLDMEIVFSAELGSTQIPLLQILRFEKGSVIDLQKPAGESVDTFVNGRVIGKG 93
+ D ++D+ + + ELG T++ + ++LR +GSV+ L AGE +D +NG +I +G
Sbjct: 50 AMQDIDLIMDIPVKLTVELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQG 109

Query: 94 EVMVFERNLAIRLNEIL 110
EV+V +R+ +I+
Sbjct: 110 EVVVVADKYGVRITDII 126


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0793TONBPROTEIN524e-10 Gram-negative bacterial tonB protein signature.
		>TONBPROTEIN#Gram-negative bacterial tonB protein signature.

Length = 239

Score = 52.3 bits (125), Expect = 4e-10
Identities = 24/52 (46%), Positives = 27/52 (51%)

Query: 91 PQKPPTPPTPPTPPTPPTPPKPIEKPKPEPKPKPKPEPKKPNHKHKALKKVE 142
P P P P P P P IEKPKP+PKPKPKP K + +K VE
Sbjct: 67 PVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKPKPKPVKKVQEQPKRDVKPVE 118



Score = 46.1 bits (109), Expect = 5e-08
Identities = 27/74 (36%), Positives = 32/74 (43%), Gaps = 8/74 (10%)

Query: 83 APKPTLAGPQKPPTPPTPPTPPTPPTPPKPIEKPKPEPKPKPKPEPKKPNHKHKALKKVE 142
A Q PP P P P P P P E P KPKPKP+PK K V+
Sbjct: 53 ADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKPKP--------KPVK 104

Query: 143 KVEEKKVVEEKKEE 156
KV+E+ + K E
Sbjct: 105 KVQEQPKRDVKPVE 118



Score = 45.0 bits (106), Expect = 1e-07
Identities = 21/65 (32%), Positives = 27/65 (41%), Gaps = 1/65 (1%)

Query: 83 APKPTLAGPQKPPTPPTPPTPPTPPTPPKPIEKPKPEPKPKPKPEPK-KPNHKHKALKKV 141
P P P P P P PPK +PKPKPKP+PK + + + V
Sbjct: 55 LEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKPKPKPVKKVQEQPKRDV 114

Query: 142 EKVEE 146
+ VE
Sbjct: 115 KPVES 119



Score = 39.6 bits (92), Expect = 8e-06
Identities = 18/57 (31%), Positives = 24/57 (42%)

Query: 74 QDPSKNNPGAPKPTLAGPQKPPTPPTPPTPPTPPTPPKPIEKPKPEPKPKPKPEPKK 130
+ P P P+ P P P P PKP KPKP+P K + +PK+
Sbjct: 56 EPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKPKPKPVKKVQEQPKR 112



Score = 38.8 bits (90), Expect = 2e-05
Identities = 43/218 (19%), Positives = 80/218 (36%), Gaps = 38/218 (17%)

Query: 101 PTPPTPPTPPKPIEKPKPEPKPKPKPEPKKPNHKHKALKKVEKVEEKKVVEEKKEEKKIV 160
P PP +P +P EP+P+P+P P+ P +E VV EK + K
Sbjct: 52 PADLEPPQAVQPPPEPVVEPEPEPEPIPEPP-------------KEAPVVIEKPKPKPKP 98

Query: 161 EQKVEQKVEQKKIEEKKPVKKEFDPNQLSFLPKEVAPPRKENNKGLDNQTRRDIDELYGE 220
+ K +KV+++ + KPV E P N T +
Sbjct: 99 KPKPVKKVQEQPKRDVKPV--------------ESRPASPFENTAPARLTSSTATAATSK 144

Query: 221 EFGDLGTAEKDFIRNNLRDIGRITQKYLEYPQVAAYLGQDGTNAVEFYLHPNGDITDLKI 280
+ + + RN + YP A L +G V+F + P+G + +++I
Sbjct: 145 PVTSVASGPRALSRNQPQ-----------YPARAQALRIEGQVKVKFDVTPDGRVDNVQI 193

Query: 281 IIGSEYKMLDDNTLKTIQIAYKDYPRPKTKTLIRIRVR 318
+ M + ++ + +P + ++ I +
Sbjct: 194 LSAKPANMFEREVKNAMRRWRYEPGKPGSGIVVNILFK 231



Score = 34.6 bits (79), Expect = 3e-04
Identities = 12/42 (28%), Positives = 17/42 (40%)

Query: 91 PQKPPTPPTPPTPPTPPTPPKPIEKPKPEPKPKPKPEPKKPN 132
P+ P P P P PKP K + +PK +P +
Sbjct: 79 PEPPKEAPVVIEKPKPKPKPKPKPVKKVQEQPKRDVKPVESR 120



Score = 31.1 bits (70), Expect = 0.005
Identities = 14/56 (25%), Positives = 20/56 (35%)

Query: 76 PSKNNPGAPKPTLAGPQKPPTPPTPPTPPTPPTPPKPIEKPKPEPKPKPKPEPKKP 131
P + P K P P PKP++K + +PK KP +P
Sbjct: 66 EPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKPKPKPVKKVQEQPKRDVKPVESRP 121


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_0797TYPE3IMSPROT290.007 Type III secretion system inner membrane S protein ...
		>TYPE3IMSPROT#Type III secretion system inner membrane S protein

family signature.
Length = 354

Score = 29.3 bits (66), Expect = 0.007
Identities = 19/64 (29%), Positives = 30/64 (46%), Gaps = 4/64 (6%)

Query: 88 LQSYSVMLFFNLLLLTDILGFLPFSIYHHFMASLIFSALFCSSLFLSNPLLGMIALMALS 147
L Y F L+L+ +LPFS S + + +L PLL + ALMA++
Sbjct: 45 LSDYYFEHFSKLMLIPAEQSYLPFSQ----ALSYVVDNVLLEFFYLCFPLLTVAALMAIA 100

Query: 148 SSLL 151
S ++
Sbjct: 101 SHVV 104


24HELPY_1400HELPY_1407N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_1400-115-2.276027Putative inner membrane insertion protein;
HELPY_1401116-2.785464Conserved hypothetical protein
HELPY_1402-117-4.055751tRNA modification GTPase
HELPY_1403016-2.793016Outer membrane protein HomD; putative signal
HELPY_1404017-2.552551Hypothetical protein
HELPY_1405220-2.220830Conserved hypothetical protein; putative signal
HELPY_1406418-1.997107Conserved hypothetical protein; putative signal
HELPY_1407218-1.236093Membrane-associated lipoprotein; putative signal
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_142060KDINNERMP425e-146 60kDa inner membrane protein signature.
		>60KDINNERMP#60kDa inner membrane protein signature.

Length = 548

Score = 425 bits (1095), Expect = e-146
Identities = 165/581 (28%), Positives = 279/581 (48%), Gaps = 85/581 (14%)

Query: 10 ILAIALSFLFIAIYSYFFQKPNKT--TTQTTKQETTNNHTATNPNAPNAQNFGTTQTIPQ 67
+L IAL F+ I+ + Q N QTT+ TT +A + P +
Sbjct: 7 LLVIALLFVSFMIWQAWEQDKNPQPQAQQTTQTTTTAAGSAADQGVPASGQ--------- 57

Query: 68 ENLLSTISFEHARIEIDSLG-RIKQVYLKDKKYLTPKQKGFLEHVG--HLFSSKEN---- 120
L ++ + + I++ G ++Q L P L L +
Sbjct: 58 -GKLISVKTDVLDLTINTRGGDVEQALL-------PAYPKELNSTQPFQLLETSPQFIYQ 109

Query: 121 AQPPL--KELPLLAADKLKPLEVRFLDPTLNNKAFNTPYSASKTTLGPNEQLV--LTQDL 176
AQ L ++ P A+ +PL +N A G NE V D
Sbjct: 110 AQSGLTGRDGPDNPANGPRPL-------------YNVEKDAYVLAEGQNELQVPMTYTDA 156

Query: 177 GTLSIIKTLTFYDDLHYDLKIAFKSPNN------------------LIPSYVITNGYRPV 218
+ KT Y + + + N L P + +
Sbjct: 157 AGNTFTKTFVLKRG-DYAVNVNYNVQNAGEKPLEISSFGQLKQSITLPPHLDTGSSNFAL 215

Query: 219 ADLDSYTFSGVLLENNDKKIEKIE---DKDAKEIKRFSNTLFLSSVDRYFTTLLFTKDPQ 275
+TF G D+K EK + D + + S +++ + +YF T +
Sbjct: 216 -----HTFRGAAYSTPDEKYEKYKFDTIADNENLNISSKGGWVAMLQQYFATAWIPHN-D 269

Query: 276 GFEALIDSEIGTKNPLGFISLKNEA-----------DLHGYIGPKDYRSLKAISPMLTDA 324
G + +G N + I K++ + ++GP+ + A++P L
Sbjct: 270 GTNNFYTANLG--NGIAAIGYKSQPVLVQPGQTGAMNSTLWVGPEIQDKMAAVAPHLDLT 327

Query: 325 IEYGLITFFAKGVFVLLDYLYQFVGNWGWAIILLTIIVRIILYPLSYKGMVSMQKLKELA 384
++YG + F ++ +F LL +++ FVGNWG++II++T IVR I+YPL+ SM K++ L
Sbjct: 328 VDYGWLWFISQPLFKLLKWIHSFVGNWGFSIIIITFIVRGIMYPLTKAQYTSMAKMRMLQ 387

Query: 385 PKMKELQEKYKGEPQKLQAHMMQLYKKHGANPLGGCLPLILQIPVFFAIYRVLYNAVELK 444
PK++ ++E+ + Q++ MM LYK NPLGGC PL++Q+P+F A+Y +L +VEL+
Sbjct: 388 PKIQAMRERLGDDKQRISQEMMALYKAEKVNPLGGCFPLLIQMPIFLALYYMLMGSVELR 447

Query: 445 SSEWILWIHDLSIMDPYFILPLLMGASMYWHQSVTPNTMTDPMQAKIFKLLPLLFTIFLI 504
+ + LWIHDLS DPY+ILP+LMG +M++ Q ++P T+TDPMQ KI +P++FT+F +
Sbjct: 448 QAPFALWIHDLSAQDPYYILPILMGVTMFFIQKMSPTTVTDPMQQKIMTFMPVIFTVFFL 507

Query: 505 TFPAGLVLYWTTNNILSVLQQLIINKVLENKKRMHAQNKKE 545
FP+GLVLY+ +N+++++QQ +I + LE K+ +H++ KK+
Sbjct: 508 WFPSGLVLYYIVSNLVTIIQQQLIYRGLE-KRGLHSREKKK 547


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1421IGASERPTASE330.002 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 32.7 bits (74), Expect = 0.002
Identities = 21/59 (35%), Positives = 29/59 (49%), Gaps = 7/59 (11%)

Query: 54 AGVKESVKEVKEESVKETNTKENHQNNIEEKKQKLETETPQEE-KITSKAPKKNLKEES 111
A KE + KET T E +E+K K+ETE QE K+TS+ K + E+
Sbjct: 1086 AQSGSETKETQTTETKETATVE------KEEKAKVETEKTQEVPKVTSQVSPKQEQSET 1138


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1422TCRTETOQM340.002 Tetracycline resistance protein TetO/TetQ/TetM family ...
		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

signature.
Length = 639

Score = 33.7 bits (77), Expect = 0.002
Identities = 32/134 (23%), Positives = 54/134 (40%), Gaps = 25/134 (18%)

Query: 216 LSIVGKPNAGKSSLLNAMLLEERA---LVSDIKGTTR-DTIEE-------------VIEL 258
+ ++ +AGK++L ++L A L S KGTTR D +
Sbjct: 6 IGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGITSFQW 65

Query: 259 KGHKVRLIDTAGIRESTDKIERLGIEKSLKSLENCDIILGVFDLSKPLEKEDFTIIDALN 318
+ KV +IDT G + ++ R SL L D + + ++ + + AL
Sbjct: 66 ENTKVNIIDTPGHMDFLAEVYR-----SLSVL---DGAILLISAKDGVQAQTRILFHALR 117

Query: 319 RAKKPCIVVLNKND 332
+ P I +NK D
Sbjct: 118 KMGIPTIFFINKID 131


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1425BINARYTOXINB280.048 Binary toxin B family signature.
		>BINARYTOXINB#Binary toxin B family signature.

Length = 764

Score = 28.1 bits (62), Expect = 0.048
Identities = 13/60 (21%), Positives = 21/60 (35%)

Query: 155 SKSMGDLLAKAMPIERILKAYSVPVGSLENYEKIYYQNAFKPKVQITFDNNSDTEIKAAL 214
+ + D L P + +A + G E + YQ + FD + IK L
Sbjct: 536 AVNPSDPLETTKPDMTLKEALKIAFGFNEPNGNLQYQGKDITEFDFNFDQQTSQNIKNQL 595


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1427LIPOLPP20294e-105 LPP20 lipoprotein precursor signature.
		>LIPOLPP20#LPP20 lipoprotein precursor signature.

Length = 175

Score = 294 bits (753), Expect = e-105
Identities = 173/175 (98%), Positives = 174/175 (99%)

Query: 1 MKNQVKKILGMSVIATMVIVGCSHAPKSGISKSNKAYKEATKGAPDWVVGDLEKVAKYEK 60
MKNQVKKILGMSV+A MVIVGCSHAPKSGISKSNKAYKEATKGAPDWVVGDLEKVAKYEK
Sbjct: 1 MKNQVKKILGMSVVAAMVIVGCSHAPKSGISKSNKAYKEATKGAPDWVVGDLEKVAKYEK 60

Query: 61 YSGVFLGRAEDLITNNDVDYSTNQATAKARANLAANLKSTLQKDLENEKTRTVDASGKRS 120
YSGVFLGRAEDLITNNDVDYSTNQATAKARANLAANLKSTLQKDLENEKTRTVDASGKRS
Sbjct: 61 YSGVFLGRAEDLITNNDVDYSTNQATAKARANLAANLKSTLQKDLENEKTRTVDASGKRS 120

Query: 121 ISGTDTEKISQLVDKELIASKMLARYVGKDRVFVLVGLDKQIVDKVREELGMVKK 175
ISGTDTEKISQLVDKELIASKMLARYVGKDRVFVLVGLDKQIVDKVREELGMVKK
Sbjct: 121 ISGTDTEKISQLVDKELIASKMLARYVGKDRVFVLVGLDKQIVDKVREELGMVKK 175


25HELPY_1551HELPY_1558N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
HELPY_1551-290.550518Flagellar hook-basal body complex protein FliE
HELPY_1552-280.373358Flagellar basal-body rod protein FlgC
HELPY_1553-180.453575Flagellar basal-body rod protein DlgB
HELPY_1554-19-0.230970Cell division protein FtsW; putative membrane
HELPY_1555-110-0.080641ABC-type transport system, periplasmic
HELPY_1556-112-0.036824Alkyl hydroperoxide reductase
HELPY_1557-2140.517229D-methionine-binding lipoprotein metQ precursor
HELPY_1558-2111.682159Penicillin-binding protein PBP2
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1560FLGHOOKFLIE777e-22 Flagellar hook-basal body complex protein FliE signa...
		>FLGHOOKFLIE#Flagellar hook-basal body complex protein FliE

signature.
Length = 103

Score = 76.6 bits (188), Expect = 7e-22
Identities = 19/77 (24%), Positives = 40/77 (51%), Gaps = 1/77 (1%)

Query: 34 EQKGGEFSKLLKQSINELNNTQEQSDKALADMATGQIK-DLHQAAIAIGKAETSMKLMLE 92
Q F+ L +++ +++TQ + G+ L+ + KA SM++ ++
Sbjct: 27 PQPTISFAGQLHAALDRISDTQTAARTQAEKFTLGEPGVALNDVMTDMQKASVSMQMGIQ 86

Query: 93 VRNKAISAYKELLRTQI 109
VRNK ++AY+E++ Q+
Sbjct: 87 VRNKLVAAYQEVMSMQV 103


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1561FLGHOOKAP1280.012 Flagellar hook-associated protein signature.
		>FLGHOOKAP1#Flagellar hook-associated protein signature.

Length = 546

Score = 28.4 bits (63), Expect = 0.012
Identities = 10/38 (26%), Positives = 15/38 (39%)

Query: 121 NVNAVVEMADLVEATRAYQANVAAFQSAKNMAQNAIGM 158
VN E +L + Y AN Q+A + I +
Sbjct: 508 GVNLDEEYGNLQRFQQYYLANAQVLQTANAIFDALINI 545


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1564FERRIBNDNGPP353e-04 Ferrichrome-binding periplasmic protein signature.
		>FERRIBNDNGPP#Ferrichrome-binding periplasmic protein signature.

Length = 296

Score = 35.3 bits (81), Expect = 3e-04
Identities = 28/183 (15%), Positives = 77/183 (42%), Gaps = 10/183 (5%)

Query: 108 NVELLKKLSPDLVVTFVG-NPKAVEHAKKFGISFLSFQETT--IAEAMQAMQ--AQATVL 162
N+ELL ++ P +V G P A+ +F + +A A +++ A L
Sbjct: 88 NLELLTEMKPSFMVWSAGYGPSPEMLARIAPGRGFNFSDGKQPLAMARKSLTEMADLLNL 147

Query: 163 EIDASKKFAKMQETLDFIAERL-KNVKKKKGVELFHKAN--KISGHQAISSDILEKGGID 219
+ A A+ ++ + + R K + + + G ++ +IL++ GI
Sbjct: 148 QSAAETHLAQYEDFIRSMKPRFVKRGARPLLLTTLIDPRHMLVFGPNSLFQEILDEYGIP 207

Query: 220 N-FGLKYVKFGRADISVEKIVK-ENPEIIFIWWVSPLSPEDVLNNPKFSTIKAIKNKQVY 277
N + + +G +S++++ ++ +++ + + ++ P + + ++ +
Sbjct: 208 NAWQGETNFWGSTAVSIDRLAAYKDVDVLCFDHDNSKDMDALMATPLWQAMPFVRAGRFQ 267

Query: 278 KLP 280
++P
Sbjct: 268 RVP 270


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
HELPY_1568TYPE3IMPPROT290.034 Type III secretion system inner membrane P protein ...
		>TYPE3IMPPROT#Type III secretion system inner membrane P protein

family signature.
Length = 224

Score = 29.4 bits (66), Expect = 0.034
Identities = 9/23 (39%), Positives = 12/23 (52%)

Query: 4 LRYKLLLFVFIGFWGLLILNLFI 26
KL+LFV + W LL L +
Sbjct: 195 TPIKLVLFVALDGWTLLSKGLIL 217



 
Contact Sachin Pundhir for Bugs/Comments.
For best view 1024 x 768 resolution & IE 6.0 or above recommended.