PredictBias

identification of genomic and pathogenicity islands in prokaryotic genome
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A) Input parameters
Genome2464.gbkThreshold dinucleotide bias2
Threshold codon bias4Threshold %GC bias3
E-value (RPSBlast)0.05Genome (non-pathogenic)
 
B) Compare a potential GI or PAI in related non-pathogenic sp. (phylogenetic tree)
Potential GI or PAI start    end  
Select Organism     
 
C) Potential GIs and PAIs in NC_008022 (download)
S.NoStartEndBiasVirulenceInsertion elementsPrediction
1MGAS10270_Spy0144MGAS10270_Spy0166Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy01442224.791161hypothetical protein
MGAS10270_Spy01451244.515311hypothetical protein
MGAS10270_Spy01461244.550247hypothetical protein
MGAS10270_Spy01471234.513443hypothetical protein
MGAS10270_Spy01480245.089657Cystathionine beta-lyase
MGAS10270_Spy01491275.457786Leucyl-tRNA synthetase
MGAS10270_Spy01501234.669009PTS system, 3-keto-L-gulonate specific IIC
MGAS10270_Spy01510215.089767PTS system, 3-keto-L-gulonate specific IIB
MGAS10270_Spy0152-2162.673824PTS system, 3-keto-L-gulonate specific IIA
MGAS10270_Spy01530152.2050463-keto-L-gulonate-6-phosphate decarboxylase
MGAS10270_Spy01540131.735971L-xylulose 5-phosphate 3-epimerase
MGAS10270_Spy0155-2121.804449L-ribulose-5-phosphate 4-epimerase
MGAS10270_Spy0156-2141.813521hypothetical protein
MGAS10270_Spy0157-2141.973393Transcription antiterminator, BglG family
MGAS10270_Spy0158-1172.812075Metal-dependent hydrolase
MGAS10270_Spy0159-2203.001054Glycine betaine transport ATP-binding protein
MGAS10270_Spy0160-1140.982203Glycine betaine-binding protein / Glycine
MGAS10270_Spy0161-115-0.167124DNA polymerase I
MGAS10270_Spy0162119-2.986480CoA binding protein
MGAS10270_Spy0163219-4.204177Ferric uptake regulation protein
MGAS10270_Spy0164221-4.589548Transcriptional regulatory protein
MGAS10270_Spy0165320-4.588434Co-activator of prophage gene expression IbrA
MGAS10270_Spy0166524-2.145009Co-activator of prophage gene expression IbrB
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0157SECA330.005 SecA protein signature.
		>SECA#SecA protein signature.

Length = 901

Score = 32.5 bits (74), Expect = 0.005
Identities = 22/107 (20%), Positives = 47/107 (43%), Gaps = 15/107 (14%)

Query: 419 EKTKLVIVSDDGIGIQKLLFKQCQRYLANGQIEAVFTTEQYQSVYDLLAVDMIVATTDTL 478
EK++ V +++ G+ + L I ++ +S+Y + ++ T L
Sbjct: 267 EKSRQVNLTERGL-------VLIEELLVKEGI-----MDEGESLYSPANIMLMHHVTAAL 314

Query: 479 KTKIPMLI-VNPILSDDDIIKLIRFSKQGRLSEHSRFSTELTKAIEA 524
+ V+ I+ D ++I + + GR + R+S L +A+EA
Sbjct: 315 RAHALFTRDVDYIVKDGEVIIVDEHT--GRTMQGRRWSDGLHQAVEA 359


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0164PF05043781e-20 Transcriptional activator
		>PF05043#Transcriptional activator

Length = 493

Score = 78.1 bits (192), Expect = 1e-20
Identities = 21/103 (20%), Positives = 46/103 (44%), Gaps = 7/103 (6%)

Query: 2 FLTWENLFLT-NQSRRRLKLLVV----ERSYNNVGNFLKEYFGGFFEIVNFDDLRLTMVD 56
++L + Q++ +LK+LV+ + V L Y FE+ + +L L+
Sbjct: 386 ITHTKHLVINLLQNQPKLKVLVMSNFDQYHAKFVAETLSYYCSNNFELEVWTELELSKES 445

Query: 57 MVSLSSEYDVIVTDMILEQTTDSEILFFNQMAPSVVANRLTDM 99
+ S YD+I+++ I+ + +++ N + + L M
Sbjct: 446 LE--DSPYDIIISNFIIPPIENKRLIYSNNINTVSLIYLLNAM 486


2MGAS10270_Spy0328MGAS10270_Spy0362Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy0328216-0.314097Tpl protein
MGAS10270_Spy03292170.352541hypothetical cytosolic protein
MGAS10270_Spy0330-1181.799417hypothetical protein
MGAS10270_Spy03310181.572590Initiation-control protein
MGAS10270_Spy03320202.378182Tetrapyrrole (Corrin/Porphyrin) methylase family
MGAS10270_Spy0333-2182.666332hypothetical membrane associated protein
MGAS10270_Spy0334-2153.522387Copper homeostasis protein cutC
MGAS10270_Spy0335-1172.964063Copper homeostasis protein cutC
MGAS10270_Spy0337-1172.790504hypothetical protein
MGAS10270_Spy0336-1172.751863Arsenate reductase family protein
MGAS10270_Spy0338-1183.328631Exodeoxyribonuclease III
MGAS10270_Spy0339-1183.278859L-lactate oxidase
MGAS10270_Spy03400213.214532interleukin-8 protease
MGAS10270_Spy03410234.142139hypothetical protein
MGAS10270_Spy0342-1234.027051hypothetical membrane spanning protein
MGAS10270_Spy0343-1255.278090Methionyl-tRNA synthetase
MGAS10270_Spy03451285.277575hypothetical protein
MGAS10270_Spy03440336.456590hypothetical protein
MGAS10270_Spy0346-1296.033144Ribonucleoside-diphosphate reductase beta chain
MGAS10270_Spy03470316.299648NrdI protein
MGAS10270_Spy03480336.274491Ribonucleoside-diphosphate reductase alpha
MGAS10270_Spy03492345.189501hypothetical protein
MGAS10270_Spy03500314.046036C3 family ADP-ribosyltransferase
MGAS10270_Spy03512250.446131hypothetical membrane associated protein
MGAS10270_Spy03520250.785551hypothetical membrane spanning protein
MGAS10270_Spy03531241.421714Transposase
MGAS10270_Spy03542250.625745Transposase
MGAS10270_Spy0355124-3.705011hypothetical protein
MGAS10270_Spy0356-124-3.518419hypothetical protein
MGAS10270_Spy0358-122-1.552670hypothetical protein
MGAS10270_Spy0357-319-0.763074hypothetical membrane spanning protein
MGAS10270_Spy0359-116-0.035346hypothetical protein
MGAS10270_Spy0360-1150.839559hypothetical protein
MGAS10270_Spy03610183.159702hypothetical protein
MGAS10270_Spy03620183.086529Short chain dehydrogenase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0340SUBTILISIN927e-22 Subtilisin serine protease family (S8) signature.
		>SUBTILISIN#Subtilisin serine protease family (S8) signature.

Length = 326

Score = 92.2 bits (229), Expect = 7e-22
Identities = 43/160 (26%), Positives = 65/160 (40%), Gaps = 24/160 (15%)

Query: 262 DIDWTQTDDETKYESHGMHVTGIVAGNSKEAAATGERFLGIAPEAQVMFMRVFANDVMGS 321
+ D D Y HG HV G +A +G+APEA ++ ++V G
Sbjct: 74 EGDPEIFKD---YNGHGTHVAGTIAAT-----ENENGVVGVAPEADLLIIKVLNKQGSGQ 125

Query: 322 AESLFIKAIEDAVALGADVINLSLGTANGAQLSGSKPLIEAIEKAKKAGVSVVVAAGNER 381
+ + I+ I A+ D+I++SLG L EA++KA + + V+ AAGNE
Sbjct: 126 YDWI-IQGIYYAIEQKVDIISMSLGGP-----EDVPELHEAVKKAVASQILVMCAAGNEG 179

Query: 382 VYGSDHDDPLATNPDYGLVGSPSTGRTPTSVAAINSKWVI 421
D+ +G P SV AIN
Sbjct: 180 DGDDRTDE----------LGYPGCYNEVISVGAINFDRHA 209



Score = 78.7 bits (194), Expect = 2e-17
Identities = 36/147 (24%), Positives = 58/147 (39%), Gaps = 18/147 (12%)

Query: 559 FDSVVSKAPSQKGNEMNHFSNWGLTSDGYLKPDITAPGGDIYSTYNDNHYGSQTGTSMAS 618
++ V+S + FSN + D+ APG DI ST Y + +GTSMA+
Sbjct: 194 YNEVISVGAINFDRHASEFSNSNN------EVDLVAPGEDILSTVPGGKYATFSGTSMAT 247

Query: 619 PQIAGASLLVKQ-YLEKTQPNLPKEKIADIVKNLLMSNAQIHVNPETKTTTSPRQQGAGL 677
P +AGA L+KQ + +L + L+ SP+ +G GL
Sbjct: 248 PHVAGALALIKQLANASFERDL----TEPELYAQLIKRT-------IPLGNSPKMEGNGL 296

Query: 678 LNIDGAVTSGLYVTGKDNYGSISLGNI 704
L + + G +S ++
Sbjct: 297 LYLTAVEELSRIFDTQRVAGILSTASL 323



Score = 40.2 bits (94), Expect = 4e-05
Identities = 11/34 (32%), Positives = 18/34 (52%), Gaps = 1/34 (2%)

Query: 127 HDWVKTKGAWDKGYKGQGKVVAVIDTGIDPAHQS 160
+ ++ W++ G+G VAV+DTG D H
Sbjct: 26 VEMIQAPAVWNQTR-GRGVKVAVLDTGCDADHPD 58


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0350BINARYTOXINA382e-05 Clostridial binary toxin A signature.
		>BINARYTOXINA#Clostridial binary toxin A signature.

Length = 454

Score = 38.5 bits (89), Expect = 2e-05
Identities = 42/170 (24%), Positives = 70/170 (41%), Gaps = 27/170 (15%)

Query: 93 INTSLDKAKGELSQLTPELRDQVAQLDAATHRLVIPWNIVVYRYVYETFLRDIGVSHADL 152
IN L + G L+ PEL +V ++ A IP N++VYR G L
Sbjct: 295 INNYL-ISNGPLNNPNPELDSKVNNIENALKLTPIPSNLIVYRRS--------GPQEFGL 345

Query: 153 TSYYRNHQFDPHILCKIK---------LGTRYTKHSFMSTT--ALKNGAMTHRPVEVRIC 201
T + F+ KI+ G T +F+ST+ ++ A R + +RI
Sbjct: 346 TLTSPEYDFN-----KIENIDAFKEKWEGKVITYPNFISTSIGSVNMSAFAKRKIILRIN 400

Query: 202 VKKGAKAAFVEPYSAVPSEVELLFPRGCQLEV--VGAYVSQDQKKLHIEA 249
+ K + A++ E E+L G + ++ V +Y KL ++A
Sbjct: 401 IPKDSPGAYLSAIPGYAGEYEVLLNHGSKFKINKVDSYKDGTVTKLILDA 450


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0359IGASERPTASE280.039 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 28.1 bits (62), Expect = 0.039
Identities = 16/61 (26%), Positives = 24/61 (39%), Gaps = 1/61 (1%)

Query: 165 KLKDSQTLEKEKKEKERQLAEEKQ-IEEERKHVEQKKLEESMLKQIREEDHKPWHQRLSE 223
+ +T E KE EEK +E E+ K + KQ + E +P + E
Sbjct: 1089 GSETKETQTTETKETATVEKEEKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEPARE 1148

Query: 224 N 224
N
Sbjct: 1149 N 1149


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0362DHBDHDRGNASE993e-27 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase sig...
		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

signature.
Length = 261

Score = 99.0 bits (246), Expect = 3e-27
Identities = 67/252 (26%), Positives = 108/252 (42%), Gaps = 24/252 (9%)

Query: 3 KVVLVTGCASGIGYAQACYFLKQGHHVYGVDKSDKPDLNGNFHFIKLDLSSELSPL---- 58
K+ +TG A GIG A A QG H+ VD + + +E P
Sbjct: 9 KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVRD 68

Query: 59 -----------FEVVPSVDILCNTAGILDAYKPLLDVSDEEVEHLFDINFFATVKLTRHY 107
+ +DIL N AG+L + +SDEE E F +N +R
Sbjct: 69 SAAIDEITARIEREMGPIDILVNVAGVLRP-GLIHSLSDEEWEATFSVNSTGVFNASRSV 127

Query: 108 LRRMVEKQSGVIINMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAKDQIHIFGIAP 167
+ M++++SG I+ + S + + AY SSK A FT+ L L+ A+ I ++P
Sbjct: 128 SKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSP 187

Query: 168 GAVKTAM-----TASDFEP---GGLADWVARETPIGRWTEPSEVAELTGFLASGKARSMQ 219
G+ +T M + G + P+ + +PS++A+ FL SG+A +
Sbjct: 188 GSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQAGHIT 247

Query: 220 GEIVKIDGGWTL 231
+ +DGG TL
Sbjct: 248 MHNLCVDGGATL 259


3MGAS10270_Spy0430MGAS10270_Spy0460Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy04303140.597006Daunorubicin resistance transmembrane protein
MGAS10270_Spy04310130.752465ABC transporter permease protein
MGAS10270_Spy0432-2110.342084Dihydroxyacetone kinase
MGAS10270_Spy0433-1110.177253Acetyl-CoA acetyltransferase
MGAS10270_Spy0434-211-1.131017Long-chain-fatty-acid--CoA ligase
MGAS10270_Spy0435112-1.585967hypothetical cytosolic protein
MGAS10270_Spy0436011-2.267281Two-component response regulator VicR
MGAS10270_Spy0437013-3.530536Two-component sensor histidine kinase VicK
MGAS10270_Spy0438015-4.967573Zn-dependent hydrolase
MGAS10270_Spy0439117-5.340509Ribonuclease III
MGAS10270_Spy0440119-6.027746Chromosome partition protein smc
MGAS10270_Spy0441324-8.942347Transcriptional regulator
MGAS10270_Spy0442428-9.359795Shikimate 5-dehydrogenase
MGAS10270_Spy0443327-9.231759hypothetical cytosolic protein
MGAS10270_Spy0444426-8.779629hypothetical protein
MGAS10270_Spy0445425-9.265112hypothetical protein
MGAS10270_Spy0446227-9.352026S-adenosylmethionine synthetase
MGAS10270_Spy0447226-9.392255hypothetical membrane associated protein
MGAS10270_Spy0448222-8.450386Glycosyltransferase involved in cell wall
MGAS10270_Spy0449320-6.635455hypothetical protein
MGAS10270_Spy0450319-6.301053UDP-glucose 6-dehydrogenase
MGAS10270_Spy0451218-4.167555Macrolide-efflux protein
MGAS10270_Spy0452322-2.316048Transcriptional regulator
MGAS10270_Spy0453321-1.769994Chromosome segregation ATPase
MGAS10270_Spy0454221-1.764213Chromosome segregation ATPase
MGAS10270_Spy0455222-3.792871hypothetical protein
MGAS10270_Spy0457120-4.019601hypothetical protein
MGAS10270_Spy0456222-5.472065Plasmid stabilization system antitoxin protein
MGAS10270_Spy0458124-6.402887Plasmid stabilization system toxin protein
MGAS10270_Spy0459-118-5.116540hypothetical cytosolic protein
MGAS10270_Spy0460-117-3.259554hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0436HTHFIS921e-23 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 91.8 bits (228), Expect = 1e-23
Identities = 29/133 (21%), Positives = 65/133 (48%), Gaps = 1/133 (0%)

Query: 3 KILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLE 62
IL+ DD+ I ++ L++ GYD+ + DL++ D+++P+ + +
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64

Query: 63 VAKEIRKT-SHVPIIMLSAKDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTET 121
+ I+K +P++++SA+++ + E GA DY+ KPF EL+ + L +
Sbjct: 65 LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKR 124

Query: 122 IETAVAEENASSG 134
+ + +++
Sbjct: 125 RPSKLEDDSQDGM 137


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0437PF06580447e-07 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 44.1 bits (104), Expect = 7e-07
Identities = 30/187 (16%), Positives = 72/187 (38%), Gaps = 34/187 (18%)

Query: 253 DETNRMMRMISDLL--NLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVY 310
+ M+ +S+L+ +L + + LA E+T +++ +F +++ ++
Sbjct: 191 TKAREMLTSLSELMRYSLRYSNARQVSLADELTVVDSYLQLASIQF---EDRLQFENQIN 247

Query: 311 EIVRDYPITSVWIEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQG 370
+ D + + ++ ++EN + + I P GGKI ++ + + + + + G
Sbjct: 248 PAIMDVQVPPMLVQT-------LVENGIKHGIAQLPQGGKILLKGTKDNGTVTLEVENTG 300

Query: 371 LGIPKTDLPLIFDRFYRVDKARSRAQGGTGLGLAIAKEIIKQHHGF---IWAKSDYGKGS 427
K + TG GL +E ++ +G I GK
Sbjct: 301 SLALKNT------------------KESTGTGLQNVRERLQMLYGTEAQIKLSEKQGKV- 341

Query: 428 TFTIVLP 434
+++P
Sbjct: 342 NAMVLIP 348


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0440GPOSANCHOR473e-07 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 47.4 bits (112), Expect = 3e-07
Identities = 48/313 (15%), Positives = 95/313 (30%), Gaps = 10/313 (3%)

Query: 209 AKVAKQFLELDANRKQLQLDILVKDIDIAQERQTKDTEALAALQQDLASYYAKRQSMEED 268
+ VA + + Q + D + + + + + + AL+ + + +E
Sbjct: 41 SAVATRSQTDTLEKVQERADKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEK 100

Query: 269 YQKFKQKKQVISQESDQTQTTLLELTKLIADLEKQIELVKLESGQ---EAEKKAEAKKHL 325
+K + + + + + +L K + + E A K L
Sbjct: 101 LRKNDKSLSEKASKIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADL 160

Query: 326 EQLQEQLDGFQAEEKQRTEQLLHIDQQLCDVKQQLNELSNALERFSSDPDQLMETLREEF 385
E+ E F + + + L L + +L + FS+ ++TL E
Sbjct: 161 EKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEK 220

Query: 386 VLLMQKEAALSNQLTALKAHLDKEKQARQHKAQEYQLLVTKLDQLNDESQKAQAHYKAQK 445
L ++A L L + + E L + +L + A A
Sbjct: 221 AALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADS 280

Query: 446 EQVEMLLQNYQEGDKRVQELERDYQLNQERLFDLLDQ-------KKGKEARKASLESIQK 498
+++ L + +LE Q+ L KK EA LE K
Sbjct: 281 AKIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNK 340

Query: 499 SHSQFYAGVRAVL 511
+R L
Sbjct: 341 ISEASRQSLRRDL 353


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0451TCRTETA384e-05 Tetracycline resistance protein signature.
		>TCRTETA#Tetracycline resistance protein signature.

Length = 399

Score = 38.3 bits (89), Expect = 4e-05
Identities = 28/141 (19%), Positives = 59/141 (41%), Gaps = 13/141 (9%)

Query: 52 SVIGVLFNLFGGVIADSFKR----KKIIITTNILCGTACLVLSFLTKEQWLVYAIVLTNV 107
+ G+L +L +I ++ ++ I GT ++L+F T W+ + I+ V
Sbjct: 253 AAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFAT-RGWMAFPIM---V 308

Query: 108 ILAFMSAFSSPSYKAFTKEIVKKDSISQLNSLLETTSTVIKVTVPMVAIFLYKLLGIHGV 167
+LA P+ +A V ++ QL L +++ + P++ +Y +
Sbjct: 309 LLAS-GGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYA----ASI 363

Query: 168 LLLDGLSFLIAALLISFILPV 188
+G +++ A L LP
Sbjct: 364 TTWNGWAWIAGAALYLLCLPA 384


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0453PF05043280.016 Transcriptional activator
		>PF05043#Transcriptional activator

Length = 493

Score = 28.0 bits (62), Expect = 0.016
Identities = 11/83 (13%), Positives = 30/83 (36%), Gaps = 10/83 (12%)

Query: 71 YLTNLPALAHDSLLLSN----VSYQTT-----EALLKLYDQSRSLNKQVFLAFDKASSYS 121
L+++ + D + S+ T + S + F+ F++
Sbjct: 45 DLSHVKSAFPDLIFHSSTNGIRIINTDDSDIEMVYHHFFKHSTHFSILEFIFFNEGCQAE 104

Query: 122 PDANQL-LSENTVLRLSSNGNEL 143
+ +S +++ R+ S N++
Sbjct: 105 SICKEFYISSSSLYRIISQINKV 127


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0454GPOSANCHOR330.002 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 33.1 bits (75), Expect = 0.002
Identities = 41/225 (18%), Positives = 86/225 (38%), Gaps = 22/225 (9%)

Query: 171 NLYDNIARYKERLKDKSDQLTTFRNARKYAFISNLVGGKKQFEANVSEIKRLEYDLAHLQ 230
++ + E + S + + A + L + + E + +
Sbjct: 225 ARKADLEKALEGAMNFSTADSA-KIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKI 283

Query: 231 DTHQDKIDSDDIKKNQQKLQLRNTKLELESSLRD------KQRRLKLLDISIEFGLYPTE 284
T + + + + +K + Q + +S RD +++L+ +E +E
Sbjct: 284 KTLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNKISE 343

Query: 285 SDLTELQQYFPDTNLKKLYEVEAYHKKLETIL------------DSEFSTE-RESLIAEI 331
+ L++ D + + ++EA H+KLE D + S E ++ + +
Sbjct: 344 ASRQSLRRDL-DASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQVEKAL 402

Query: 332 DELESQLTTLNQELQELGNIPNLS-SEYLENYSKLTATINALKEQ 375
+E S+L L + +EL L+ E E +KL A ALKE+
Sbjct: 403 EEANSKLAALEKLNKELEESKKLTEKEKAELQAKLEAEAKALKEK 447


4MGAS10270_Spy0535MGAS10270_Spy0591Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy0535017-3.953384hypothetical cytosolic protein
MGAS10270_Spy0536020-4.911891Site-specific recombinase
MGAS10270_Spy0537-120-3.507939phage protein
MGAS10270_Spy0538222-2.896669phage transcriptional repressor
MGAS10270_Spy0539326-3.948503phage protein
MGAS10270_Spy0540225-4.249333phage protein
MGAS10270_Spy0541328-3.103808phage protein
MGAS10270_Spy0542429-3.296235phage protein
MGAS10270_Spy0543725-4.451728hypothetical protein
MGAS10270_Spy0544325-4.320503phage protein
MGAS10270_Spy0545121-2.584672hypothetical protein
MGAS10270_Spy0546120-2.690019phage protein
MGAS10270_Spy0547-117-1.808608Transcriptional regulator, Cro/CI family
MGAS10270_Spy0548016-1.484387phage protein
MGAS10270_Spy0549116-1.447757phage protein
MGAS10270_Spy0550116-1.213419phage DNA/RNA helicase
MGAS10270_Spy0551217-1.694452phage protein
MGAS10270_Spy0552221-1.477140phage protein
MGAS10270_Spy0553323-2.036493DNA primase
MGAS10270_Spy0554224-4.369913phage protein
MGAS10270_Spy0555531-3.331662phage protein
MGAS10270_Spy0556730-3.174124phage protein
MGAS10270_Spy0557527-3.022577phage protein
MGAS10270_Spy0558325-2.907337phage protein
MGAS10270_Spy0559121-2.458560phage protein
MGAS10270_Spy0560120-1.320524phage protein
MGAS10270_Spy0561019-0.933852phage protein
MGAS10270_Spy0562220-1.772057Methyltransferase
MGAS10270_Spy0563220-1.615444Adenine-specific methyltransferase
MGAS10270_Spy0564423-1.370700phage protein
MGAS10270_Spy0565525-1.469881phage protein
MGAS10270_Spy0566526-1.712015phage protein
MGAS10270_Spy0567424-2.361747phage protein
MGAS10270_Spy0568118-1.360783phage protein
MGAS10270_Spy0569218-1.725697phage protein
MGAS10270_Spy0570218-1.710704phage endonuclease
MGAS10270_Spy0571018-1.355757phage terminase small subunit
MGAS10270_Spy0572016-1.085545hypothetical protein
MGAS10270_Spy0573014-0.780340Terminase large subunit
MGAS10270_Spy0574217-0.587984phage protein
MGAS10270_Spy0575217-0.151316phage protein
MGAS10270_Spy0576117-0.454776Portal protein
MGAS10270_Spy0577217-0.468014ATP-dependent endopeptidase clp proteolytic
MGAS10270_Spy0578318-1.460077phage protein
MGAS10270_Spy0579123-1.249179phage protein
MGAS10270_Spy0580219-1.569864phage protein
MGAS10270_Spy0581219-1.903339phage protein
MGAS10270_Spy05823151.437728phage protein
MGAS10270_Spy05833151.594938phage protein
MGAS10270_Spy05843172.519431Major tail protein
MGAS10270_Spy05853172.474186phage protein
MGAS10270_Spy05863203.232344phage protein
MGAS10270_Spy05873203.030623phage protein
MGAS10270_Spy05884263.121970phage protein
MGAS10270_Spy05894262.883227phage endopeptidase
MGAS10270_Spy05905252.414586Hyaluronoglucosaminidase
MGAS10270_Spy05915253.497422phage infection protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0561PF06580260.021 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 26.0 bits (57), Expect = 0.021
Identities = 7/45 (15%), Positives = 19/45 (42%)

Query: 29 LFLAIAIFGMMVTVSYFSYRDARQYYESQITGLRTQLSRTQKQLK 73
+ + + M ++ YF + + Y +++I + + QL
Sbjct: 120 IIFNVVVVTFMWSLLYFGWHFFKNYKQAEIDQWKMASMAQEAQLM 164


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0567PRPHPHLPASEC300.016 Prokaryotic zinc-dependent phospholipase C signature.
		>PRPHPHLPASEC#Prokaryotic zinc-dependent phospholipase C signature.

Length = 398

Score = 29.6 bits (66), Expect = 0.016
Identities = 32/180 (17%), Positives = 65/180 (36%), Gaps = 14/180 (7%)

Query: 109 NKIRQKEPKSVDDNLKLLVNSFGNELSSYLYGADWSDTKYDLAVEIINKHDVFSGYKQTE 168
N + + EP+SV NL++L +EL D+ YDL + D + + +
Sbjct: 52 NDLSKNEPESVRKNLEIL-KENMHELQLGSTYPDYDKNAYDLYQDHFWDPDTDNNFSKDN 110

Query: 169 TYKKADKPYDEGELEKNKKLTQLEQLQQLGRLQQL-----EQLQQLGRLQQLEQLQQLGR 223
++ A D GE + K Q G +Q E + G + +
Sbjct: 111 SWYLAYSIPDTGESQIRKFSALARYEWQRGNYKQATFYLGEAMHYFGDIDTPYHPANVTA 170

Query: 224 LQQLGRLEQLEPTNYSYEAFSDIEDAIFYLDPPYENTTQKSYKGDFNSQAFYDWAFGMSK 283
+ G ++ +E F++ + ++ T + Y ++ F W+ ++
Sbjct: 171 VDSAGHVK--------FETFAEERKEQYKINTAGCKTNEDFYADILKNKDFNAWSKEYAR 222


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0589SSPAMPROTEIN290.036 Salmonella surface presentation of antigen gene typ...
		>SSPAMPROTEIN#Salmonella surface presentation of antigen gene type M

signature.
Length = 147

Score = 28.9 bits (64), Expect = 0.036
Identities = 23/65 (35%), Positives = 29/65 (44%), Gaps = 6/65 (9%)

Query: 387 ERINALENNQKVITNNQKQFELNLPKYLNDINGKRVWYEKPDDNIEHKIGDYWFEKNGKY 446
E I AL Q ++ K EL + + I KR EK + + K YW K G Y
Sbjct: 66 EEIYALLRKQSIVRRQIKDLELQIIQ----IQEKRSELEKKREEFQEK-SKYWLRKEGNY 120

Query: 447 QRTWI 451
QR WI
Sbjct: 121 QR-WI 124


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0590PF072125630.0 Hyaluronoglucosaminidase
		>PF07212#Hyaluronoglucosaminidase

Length = 336

Score = 563 bits (1452), Expect = 0.0
Identities = 336/336 (100%), Positives = 336/336 (100%)

Query: 1 MTETIPLRVQFKRMTAEEWTRSDVILLESEIGFETDTGYAKFGDGKNQFSKLKYLNKPDL 60
MTETIPLRVQFKRMTAEEWTRSDVILLESEIGFETDTGYAKFGDGKNQFSKLKYLNKPDL
Sbjct: 1 MTETIPLRVQFKRMTAEEWTRSDVILLESEIGFETDTGYAKFGDGKNQFSKLKYLNKPDL 60

Query: 61 GAFAQKEETNSKITKLESSKADKNAVYLKAESKIELDKKLNLKGGVMTGQLQFKPNKSGI 120
GAFAQKEETNSKITKLESSKADKNAVYLKAESKIELDKKLNLKGGVMTGQLQFKPNKSGI
Sbjct: 61 GAFAQKEETNSKITKLESSKADKNAVYLKAESKIELDKKLNLKGGVMTGQLQFKPNKSGI 120

Query: 121 KPSSSVGGAINIDMSKSEGAGVVVYSNNDTSDGPLMSLRTGKETFNQSALFVDYSGKTNA 180
KPSSSVGGAINIDMSKSEGAGVVVYSNNDTSDGPLMSLRTGKETFNQSALFVDYSGKTNA
Sbjct: 121 KPSSSVGGAINIDMSKSEGAGVVVYSNNDTSDGPLMSLRTGKETFNQSALFVDYSGKTNA 180

Query: 181 VNIAMRQPTTPNFSSALNITSGNENGSAMQIRGVEKALGTLKITHENPNVEANYDENAAA 240
VNIAMRQPTTPNFSSALNITSGNENGSAMQIRGVEKALGTLKITHENPNVEANYDENAAA
Sbjct: 181 VNIAMRQPTTPNFSSALNITSGNENGSAMQIRGVEKALGTLKITHENPNVEANYDENAAA 240

Query: 241 LSIDIVKKQKGGKGTAAQGIYINSTSGTTGKLLRIRNLGDDKFYVKHDGGFYAKKTSQID 300
LSIDIVKKQKGGKGTAAQGIYINSTSGTTGKLLRIRNLGDDKFYVKHDGGFYAKKTSQID
Sbjct: 241 LSIDIVKKQKGGKGTAAQGIYINSTSGTTGKLLRIRNLGDDKFYVKHDGGFYAKKTSQID 300

Query: 301 GNLKLKNPTADDHAATKAYVDSEVKKLKALLMDKQV 336
GNLKLKNPTADDHAATKAYVDSEVKKLKALLMDKQV
Sbjct: 301 GNLKLKNPTADDHAATKAYVDSEVKKLKALLMDKQV 336


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0591RTXTOXIND340.003 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 33.6 bits (77), Expect = 0.003
Identities = 27/145 (18%), Positives = 51/145 (35%), Gaps = 21/145 (14%)

Query: 158 RLSSSYQSGINGLKAQLANDKI---GLQAEIQATAQGLSQKYDNELRQLSAKITTTSSGT 214
RL+S + + + Q ++ +AE T +Y+N R +++ SS
Sbjct: 186 RLTSLIKEQFSTWQNQKYQKELNLDKKRAERL-TVLARINRYENLSRVEKSRLDDFSSLL 244

Query: 215 TEAYESKLAGLRAEFTRSNQGMRIELESQISGLRAVQQSTASQISQEIRDRTGAVSRVQQ 274
+ +K A L E E++ + SQ+ Q + A Q
Sbjct: 245 HKQAIAKHAVL-------------EQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQL 291

Query: 275 DLESYQR----RLQDAEDNYSSLTH 295
+ ++ +L+ DN LT
Sbjct: 292 VTQLFKNEILDKLRQTTDNIGLLTL 316


5MGAS10270_Spy0611MGAS10270_Spy0622Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy0611218-0.199112DNA gyrase subunit B
MGAS10270_Spy0612118-1.238753DNA gyrase subunit B
MGAS10270_Spy0613215-1.919117Septation ring formation regulator
MGAS10270_Spy0614018-2.153735hypothetical cytosolic protein
MGAS10270_Spy0615017-2.378694Enolase
MGAS10270_Spy0616120-3.866973Streptolysin S precursor
MGAS10270_Spy0617019-3.891923Streptolysin S biosynthesis protein SagB
MGAS10270_Spy0618-120-4.167767Streptolysin S biosynthesis protein SagC
MGAS10270_Spy0619020-4.658344Streptolysin S biosynthesis protein SagD
MGAS10270_Spy0620020-5.626744Streptolysin S putative self-immunity protein
MGAS10270_Spy0621-113-3.702254Streptolysin S biosynthesis protein SagF
MGAS10270_Spy0622-214-3.905729Streptolysin S export ATP-binding protein SagG
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0621TYPE3IMSPROT310.004 Type III secretion system inner membrane S protein ...
		>TYPE3IMSPROT#Type III secretion system inner membrane S protein

family signature.
Length = 354

Score = 30.9 bits (70), Expect = 0.004
Identities = 15/76 (19%), Positives = 32/76 (42%), Gaps = 1/76 (1%)

Query: 37 SYQDFLDVLLSLFQFVVIILVLFFYSATINLGEVLTFLTQTSWHWQILCYLVLYLMAIIE 96
S + ++ L S+ + V++ ++++ NL +L T L +L + +I
Sbjct: 133 SIKSLVEFLKSILKVVLLSILIWII-IKGNLVTLLQLPTCGIECITPLLGQILRQLMVIC 191

Query: 97 MTLLVLILIFDVLLQK 112
V+I I D +
Sbjct: 192 TVGFVVISIADYAFEY 207


6MGAS10270_Spy0658MGAS10270_Spy0671Y        NNGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy0658-315-4.240287alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase
MGAS10270_Spy0659-317-5.700165alpha-L-Rha alpha-1,3-L-rhamnosyltransferase
MGAS10270_Spy0660-219-5.967008Polysaccharide export ABC transporter permease
MGAS10270_Spy0661-120-6.322582Polysaccharide export ATP-binding protein
MGAS10270_Spy0662-121-7.175592Glycosyltransferase
MGAS10270_Spy0663021-7.553885alpha-L-Rha alpha-1,2-L-rhamnosyltransferase /
MGAS10270_Spy0664119-6.290490Phosphoglycerol transferase
MGAS10270_Spy0665117-6.095465Glycosyltransferase involved in cell wall
MGAS10270_Spy0666217-6.300144hypothetical protein
MGAS10270_Spy0667218-5.414552Transcriptional activator amrA
MGAS10270_Spy0668216-3.442384hypothetical membrane spanning protein
MGAS10270_Spy0669-116-0.892524Tripeptidase T
MGAS10270_Spy0670-120-1.158989Pore forming protein ebsA
MGAS10270_Spy06713240.590025Ferredoxin
7MGAS10270_Spy0701MGAS10270_Spy0710Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy0701-219-3.352934hypothetical protein
MGAS10270_Spy0702-217-3.125269Carbamoyl-phosphate synthase large chain
MGAS10270_Spy0703-118-4.370599periplasmic component of efflux system
MGAS10270_Spy0704-119-5.072343ABC transporter ATP-binding protein
MGAS10270_Spy0705117-4.362635ABC transporter permease protein
MGAS10270_Spy0706018-4.442398hypothetical protein / Glycerophosphodiester
MGAS10270_Spy0707016-3.596699SSU ribosomal protein S16P
MGAS10270_Spy0708016-4.295725RNA binding protein
MGAS10270_Spy0709015-4.070822hypothetical protein
MGAS10270_Spy0710-113-3.211761Cell surface protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0703RTXTOXIND446e-07 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 44.4 bits (105), Expect = 6e-07
Identities = 21/112 (18%), Positives = 45/112 (40%), Gaps = 13/112 (11%)

Query: 170 QQLQDLNDAYADAQAEVNKAQIALNDTVVISSVSGTVVE-----VNNDIDPSSKNSQTLV 224
+L+ D E+ K + +V+ + VS V + + ++TL+
Sbjct: 302 DKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTT----AETLM 357

Query: 225 HVATEGQ-LQVKGTLTEYDLANVKVGQSVKIKSKVYSNQEW---TGKISYVS 272
+ E L+V + D+ + VGQ+ IK + + + GK+ ++
Sbjct: 358 VIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNIN 409



Score = 37.5 bits (87), Expect = 8e-05
Identities = 24/185 (12%), Positives = 55/185 (29%), Gaps = 29/185 (15%)

Query: 21 ITLVLIITGVVLWKQQQNTLTADIDKEPYSTVSVTEGSIASSTLLSGTVKALSEEYIYFD 80
++ + + ++ ++ V+ G + S S +K + +
Sbjct: 62 YFIMGFLVIAFIL-----SVLGQVEI-----VATANGKLTHSGR-SKEIKPIENSIV--- 107

Query: 81 ANKGNDATVTVKVGDQVTQGQQLVQYNTTTA-------QSAYDTAVRSLNKIGRQINHLK 133
+ VK G+ V +G L++ A QS+ A + ++
Sbjct: 108 ------KEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIE 161

Query: 134 TYGVPAV--STETNKDEATGEETTTTVQPSAQQNANYKQQLQDLNDAYADAQAEVNKAQI 191
+P + E + EE +Q + ++ Q +AE
Sbjct: 162 LNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLA 221

Query: 192 ALNDT 196
+N
Sbjct: 222 RINRY 226


8MGAS10270_Spy0796MGAS10270_Spy0848Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy0796226-3.979355DNA integration/recombination/inversion protein
MGAS10270_Spy0797228-6.320156phage protein
MGAS10270_Spy0798329-4.048461phage protein
MGAS10270_Spy0799328-4.111592phage protein
MGAS10270_Spy0800325-3.793983phage protein
MGAS10270_Spy0801724-3.735874Transcriptional regulator, MerR family
MGAS10270_Spy0802423-4.199488Transcriptional regulator, Cro family
MGAS10270_Spy0803122-2.881266phage protein
MGAS10270_Spy0804220-3.023050phage protein
MGAS10270_Spy0805118-2.135159Transcriptional regulator, Cro/CI family
MGAS10270_Spy0806115-2.266215phage protein
MGAS10270_Spy0807116-1.715793phage protein
MGAS10270_Spy0808117-1.529790phage DNA/RNA helicase
MGAS10270_Spy0809220-1.745093phage protein
MGAS10270_Spy0810121-1.068339phage protein
MGAS10270_Spy0811321-2.456907DNA primase
MGAS10270_Spy0812226-2.241327phage protein
MGAS10270_Spy0813329-2.632393phage protein
MGAS10270_Spy0814129-1.772577phage protein
MGAS10270_Spy0815125-1.430610phage protein
MGAS10270_Spy0816226-1.010611phage protein
MGAS10270_Spy08171281.454693phage protein
MGAS10270_Spy08180272.053748phage protein
MGAS10270_Spy08191221.838365phage protein
MGAS10270_Spy08202231.424538phage encoded transcriptional regulator, ArpU
MGAS10270_Spy08213231.237352phage protein
MGAS10270_Spy08223220.856647phage protein
MGAS10270_Spy08233200.610087phage protein
MGAS10270_Spy08242180.804002Terminase large subunit
MGAS10270_Spy08254200.724703Portal protein
MGAS10270_Spy08264200.611788phage protein
MGAS10270_Spy08275251.032441phage protein
MGAS10270_Spy08284231.103348phage scaffold protein
MGAS10270_Spy08294240.904023phage protein
MGAS10270_Spy08304240.429843phage protein
MGAS10270_Spy08316220.060045phage protein
MGAS10270_Spy08324200.664923phage protein
MGAS10270_Spy08333211.974694antigen C
MGAS10270_Spy08343211.316865antigen B
MGAS10270_Spy08353201.777894antigen A
MGAS10270_Spy08363201.973725phage protein
MGAS10270_Spy08373201.928245phage protein
MGAS10270_Spy08383201.711196phage protein
MGAS10270_Spy08393191.066118phage tail protein
MGAS10270_Spy08403181.314487phage protein
MGAS10270_Spy08414161.008327phage structural protein
MGAS10270_Spy0842518-0.780408phage protein
MGAS10270_Spy0843521-0.532277phage protein
MGAS10270_Spy0844521-0.098773phage protein
MGAS10270_Spy0845620-0.175448N-acetylmuramoyl-L-alanine amidase
MGAS10270_Spy0846517-1.579331phage-associated cell wall hydrolase
MGAS10270_Spy0847315-2.998923phage protein
MGAS10270_Spy0848315-2.711292phage protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0808SECA290.028 SecA protein signature.
		>SECA#SecA protein signature.

Length = 901

Score = 29.5 bits (66), Expect = 0.028
Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 1/68 (1%)

Query: 165 VIKH-YEKLAKGKQAIVYTHSVEASHLVSDTFNQAGYQSQSVSGKTSKSEREEAMQAFRD 223
+I+ E+ AKG+ +V T S+E S LVS+ +AG + ++ K +E QA
Sbjct: 438 IIEDIKERTAKGQPVLVGTISIEKSELVSNELTKAGIKHNVLNAKFHANEAAIVAQAGYP 497

Query: 224 GKLRILVN 231
+ I N
Sbjct: 498 AAVTIATN 505


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0832PF05272250.046 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 25.4 bits (55), Expect = 0.046
Identities = 14/55 (25%), Positives = 19/55 (34%), Gaps = 4/55 (7%)

Query: 10 TPQKTGKKDKLGNDITKDVVKRDAKGRFTEWSADDVSLYGRDLTSSARKLLTNQV 64
P+K G D D + F EW D+V+ L R LL +
Sbjct: 402 PPKKRDPSAGAGTDPGGPGGGDDGEDPFGEWLDDEVA----RLRLRGRWLLKPRR 452


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0840FLGFLGJ396e-05 Flagellar protein FlgJ signature.
		>FLGFLGJ#Flagellar protein FlgJ signature.

Length = 313

Score = 39.3 bits (91), Expect = 6e-05
Identities = 32/139 (23%), Positives = 56/139 (40%), Gaps = 9/139 (6%)

Query: 294 VFSQLYLESFWGDTPVGRAD----NNWGGI----TWTGATTRPSGINVSQGQPRAEGGHY 345
+ +Q LES WG + R + N G+ W G T + G+ + +
Sbjct: 174 ILAQAALESGWGQRQIRRENGEPSYNLFGVKASGNWKGPVTEITTTEYENGEAKKVKAKF 233

Query: 346 NHYASVDDYLKDYTYLLAEQGIY-AVKGKLTIDEYTRGLFRVGGATYDYAAAGYDHYAPL 404
Y+S + L DY LL Y AV + ++ + L G AT + A +
Sbjct: 234 RVYSSYLEALSDYVGLLTRNPRYAAVTTAASAEQGAQALQDAGYATDPHYARKLTNMIQQ 293

Query: 405 MRDIRAGINRNNNGAMDNV 423
M+ I +++ + +DN+
Sbjct: 294 MKSISDKVSKTYSMNIDNL 312


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0843CARBMTKINASE260.007 Bacterial carbamate kinase signature.
		>CARBMTKINASE#Bacterial carbamate kinase signature.

Length = 314

Score = 25.9 bits (57), Expect = 0.007
Identities = 13/41 (31%), Positives = 18/41 (43%), Gaps = 14/41 (34%)

Query: 25 EFGWITLEDVPKKYR--------------DKVKQLVESGNI 51
E GWI ED + +R + +K+LVE G I
Sbjct: 148 EKGWIVKEDSGRGWRRVVPSPDPKGHVEAETIKKLVERGVI 188


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0844FRAGILYSIN290.004 Fragilysin metallopeptidase (M10C) enterotoxin signat...
		>FRAGILYSIN#Fragilysin metallopeptidase (M10C) enterotoxin

signature.
Length = 405

Score = 28.9 bits (64), Expect = 0.004
Identities = 15/63 (23%), Positives = 25/63 (39%), Gaps = 5/63 (7%)

Query: 25 VSAPVKHVLDNNKKAMEALESAIVKISDD-----LKDNNFKWTESKNHRDRLQKVQDQHE 79
+ APV +D + L + + +SD LKDN F + R + D
Sbjct: 38 IDAPVTASIDLQSVSYTDLATQLNDVSDFGKMIILKDNGFNRQVHVSMDKRTKIQLDNEN 97

Query: 80 IRI 82
+R+
Sbjct: 98 VRL 100


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0845UREASE280.009 Urea amidohydrolase (urease) protein signature.
		>UREASE#Urea amidohydrolase (urease) protein signature.

Length = 570

Score = 27.8 bits (62), Expect = 0.009
Identities = 11/54 (20%), Positives = 21/54 (38%), Gaps = 5/54 (9%)

Query: 46 VARNAVEAVEQIAYDKDIK---GIEKLTEAKIAVRDELSKHNVYLSDK--QMEV 94
++V V Q + D + G+ K A R + K ++ + +EV
Sbjct: 486 RTNSSVTFVSQASLDAGLAGRLGVAKELVAVQNTRGGIGKASMIHNSLTPHIEV 539


9MGAS10270_Spy0885MGAS10270_Spy0893Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy0885113-3.674725hypothetical membrane spanning protein
MGAS10270_Spy0886315-3.650018hypothetical cytosolic protein
MGAS10270_Spy08872190.224719hypothetical cytosolic protein
MGAS10270_Spy08881175.032933hypothetical cytosolic protein
MGAS10270_Spy08891165.520026hypothetical protein
MGAS10270_Spy08900166.402157Nucleoside diphosphate kinase
MGAS10270_Spy08910166.061326Nucleoside diphosphate kinase
MGAS10270_Spy08920165.720022GTP-binding protein lepA
MGAS10270_Spy08932175.549092Collagen-like surface protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0888PF04605280.008 Virulence-associated protein D (VapD)
		>PF04605#Virulence-associated protein D (VapD)

Length = 125

Score = 27.5 bits (61), Expect = 0.008
Identities = 15/44 (34%), Positives = 23/44 (52%), Gaps = 5/44 (11%)

Query: 7 RMILMFDMPTDTAEE-----RKAYRKFRKFLLSEGFIMHQFSIY 45
R + FD+ T + E+ R+ Y +KF+L GF Q+S Y
Sbjct: 5 RKAINFDLSTKSLEKYFKDTREPYSLIKKFMLENGFEHRQYSGY 48


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0892TCRTETOQM1123e-28 Tetracycline resistance protein TetO/TetQ/TetM family ...
		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

signature.
Length = 639

Score = 112 bits (282), Expect = 3e-28
Identities = 51/156 (32%), Positives = 81/156 (51%), Gaps = 8/156 (5%)

Query: 12 KIRNFSIIAHIDHGKSTLADRILEK---TETVSSREMQAQLLDSMDLERERGITIKLNAI 68
KI N ++AH+D GK+TL + +L + S + D+ LER+RGITI+
Sbjct: 2 KIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGIT 61

Query: 69 ELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLA 128
+ E ++IDTPGH+DF EV RSL+ +GAIL++ A G++AQT +
Sbjct: 62 SFQW-----ENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHAL 116

Query: 129 LDNDLEILPVINKIDLPAADPERVRHEVEDVIGLDA 164
+ + INKID D V ++++ + +
Sbjct: 117 RKMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAEI 152



Score = 91.5 bits (227), Expect = 2e-21
Identities = 44/214 (20%), Positives = 93/214 (43%), Gaps = 16/214 (7%)

Query: 171 SAKAGIGIEEILEQIVEKVPAPTGDVDAPLQALIFDSVYDAYRGVILQVRIVNGIVKSGD 230
SAK IGI+ ++E I K + T + L +F Y R + +R+ +G++ D
Sbjct: 220 SAKNNIGIDNLIEVITNKFYSSTHRGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLHLRD 279

Query: 231 KIQMMSNGKTFDVTEVGIFTP-KAVGRDFLATGDVGYVAASIKTVADTRVGDTVTLANNP 289
+++ K +TE+ + D +G++ + + +GDT L
Sbjct: 280 SVRISEKEKI-KITEMYTSINGELCKIDKAYSGEIVILQNEFLKLNSV-LGDTKLLPQRE 337

Query: 290 AKEALHGYKQMNPMVFAGIYPIESNKYNDLREALEKLQLNDASLQFE--PETSQALGFGF 347
E P++ + P + + L +AL ++ +D L++ T + +
Sbjct: 338 RIENPL------PLLQTTVEPSKPQQREMLLDALLEISDSDPLLRYYVDSATHEII---- 387

Query: 348 RCGFLGLLHMDVIQERLEREFNIDLIMTAPSVVY 381
FLG + M+V L+ ++++++ + P+V+Y
Sbjct: 388 -LSFLGKVQMEVTCALLQEKYHVEIEIKEPTVIY 420



Score = 43.3 bits (102), Expect = 2e-06
Identities = 21/104 (20%), Positives = 41/104 (39%), Gaps = 12/104 (11%)

Query: 393 VSNPSEFPDPTRVAFIE----------EPYVKAQIMVPQEFVGAVMELSQRKRGDFVTMD 442
VS P++F + + EPY+ +I PQE++ + + + V
Sbjct: 510 VSTPADFRMLAPIVLEQVLKKAGTELLEPYLSFKIYAPQEYLSRAYTDAPKYCANIVDTQ 569

Query: 443 YIDDNRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDYDMSEYR 486
+ +N V + +IP I ++ L T G + ++ Y
Sbjct: 570 -LKNNEVILSGEIPARCI-QEYRSDLTFFTNGRSVCLTELKGYH 611


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0893GPOSANCHOR722e-15 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 71.6 bits (175), Expect = 2e-15
Identities = 36/105 (34%), Positives = 48/105 (45%), Gaps = 12/105 (11%)

Query: 378 QPGKPAPKTPEVPQKPDTAPHTPKTPQIPGQSKDVTPAPQNPSNRGLNKPQTQGGNQLAK 437
+ K A + ++ + TP P + +G NQ
Sbjct: 447 KLAKQAEELAKLRAGKASDSQTPDAK----------PGNKAVPGKGQAPQAGTKPNQ--N 494

Query: 438 TPAAHDTHRQLPATGETTNPFFTAAAVAIMTTAGVVAVAKRQENN 482
+T RQLP+TGET NPFFTAAA+ +M TAGV AV KR+E N
Sbjct: 495 KAPMKETKRQLPSTGETANPFFTAAALTVMATAGVAAVVKRKEEN 539


10MGAS10270_Spy0906MGAS10270_Spy0927Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy0906-1163.061819Xaa-His dipeptidase
MGAS10270_Spy09072192.715102tRNA
MGAS10270_Spy09086261.980229LSU ribosomal protein L10P
MGAS10270_Spy09094210.988042LSU ribosomal protein L12P (L7/L12)
MGAS10270_Spy0910227-0.532129hypothetical protein
MGAS10270_Spy0911425-2.257122hypothetical protein
MGAS10270_Spy0912623-4.603157hypothetical protein
MGAS10270_Spy0913624-6.711219DNA-cytosine methyltransferase
MGAS10270_Spy0914523-7.559111Relaxase
MGAS10270_Spy0915426-8.591979Relaxase
MGAS10270_Spy0916427-8.592703Relaxase
MGAS10270_Spy0917529-9.465866Lantibiotic biosynthesis two-component response
MGAS10270_Spy0918529-9.401698Lantibiotic biosynthesis sensor protein
MGAS10270_Spy0919629-9.403041Lantibiotic srtA precursor
MGAS10270_Spy0920629-9.573313Lantibiotic transport permease protein /
MGAS10270_Spy0921629-9.301880Lanthionine synthetase
MGAS10270_Spy0922626-9.090865serine/threoninedehydratase
MGAS10270_Spy0923324-8.061586Lantibiotic transport ATP-binding protein
MGAS10270_Spy0924325-8.408143Lantibiotic transport permease protein
MGAS10270_Spy0925226-7.713602Lantibiotic transport permease protein
MGAS10270_Spy0926127-5.626744Transcriptional regulator, Cro/CI family
MGAS10270_Spy0928125-5.689518hypothetical protein
MGAS10270_Spy0927123-3.321377hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0917HTHFIS742e-17 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 73.7 bits (181), Expect = 2e-17
Identities = 30/130 (23%), Positives = 57/130 (43%), Gaps = 1/130 (0%)

Query: 3 KILAIDDDKEILKLMKTALEIENYHVITCQEIELPIVFDDFKGYDLILLDIMMPNISGTE 62
IL DDD I ++ AL Y V + DL++ D++MP+ + +
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64

Query: 63 FCYKIREE-VHSPIIFVSALDGDNEIVQALNIGGDDFIVKPFSLKQFVAKVNSHLKREER 121
+I++ P++ +SA + ++A G D++ KPF L + + + L +R
Sbjct: 65 LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKR 124

Query: 122 AKIKNEAEER 131
K E + +
Sbjct: 125 RPSKLEDDSQ 134


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0919NISIN270.001 Nisin signature.
		>NISIN#Nisin signature.

Length = 57

Score = 26.7 bits (58), Expect = 0.001
Identities = 17/32 (53%), Positives = 23/32 (71%), Gaps = 2/32 (6%)

Query: 4 TIKDFDLDL-KTNKKDT-ATPYVGSRYLCTPG 33
+ KDF+LDL +KKD+ A+P + S LCTPG
Sbjct: 2 STKDFNLDLVSVSKKDSGASPRITSISLCTPG 33


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0924ANTHRAXTOXNA300.010 Anthrax toxin LF subunit signature.
		>ANTHRAXTOXNA#Anthrax toxin LF subunit signature.

Length = 800

Score = 30.1 bits (67), Expect = 0.010
Identities = 17/47 (36%), Positives = 28/47 (59%), Gaps = 7/47 (14%)

Query: 184 NKWYLFPYDWSLKLLEPMTRMGINSIPFGAEFVPDYSQIFISLFLGI 230
NK Y+ +W+ +P+T+ IN+IP AEF+ + S I S +G+
Sbjct: 639 NKAYI---EWT----DPITKAKINTIPTSAEFIKNLSSIRRSSNVGV 678


11MGAS10270_Spy0939MGAS10270_Spy0955Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy09392150.666341Dihydroneopterin aldolase
MGAS10270_Spy09402150.0919282-amino-4-hydroxy-6-
MGAS10270_Spy0941215-0.232398UDP-N-acetylenolpyruvoylglucosamine reductase
MGAS10270_Spy0942117-0.369696Spermidine/putrescine transport ATP-binding
MGAS10270_Spy09432160.221492Spermidine/putrescine transport system permease
MGAS10270_Spy09442150.625162Spermidine/putrescine transport system permease
MGAS10270_Spy09451150.687821Spermidine/putrescine-binding protein
MGAS10270_Spy09461160.681632Transcriptional regulatory protein dpiA
MGAS10270_Spy09471150.231842Sensor kinase dpiB
MGAS10270_Spy0948217-0.579037Malate-sodium symport
MGAS10270_Spy0949218-1.687350NAD-dependent malic enzyme
MGAS10270_Spy0950120-3.821346Zn-dependent alcohol dehydrogenase
MGAS10270_Spy0951223-4.925857Class B acid phosphatase
MGAS10270_Spy0952121-4.637686Chloride channel protein
MGAS10270_Spy0953021-4.792759Lipase/Acylhydrolase family protein
MGAS10270_Spy0954-117-4.898452hypothetical protein
MGAS10270_Spy0955-116-3.248908hypothetical membrane spanning protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0945MYCMG045371e-04 Hypothetical mycoplasma lipoprotein (MG045) signature.
		>MYCMG045#Hypothetical mycoplasma lipoprotein (MG045) signature.

Length = 483

Score = 36.6 bits (84), Expect = 1e-04
Identities = 24/82 (29%), Positives = 42/82 (51%), Gaps = 4/82 (4%)

Query: 31 SGSQSDKLVIYNWGDYIDPALLKKFTKETGIEVQYETFDSNEAMYTKIKQGGTTYDIAVP 90
S S V+ N+ YI P LL++ + + + T+ SNE + TY +AV
Sbjct: 21 SSCGSTTFVLANFESYISPLLLER--VQEKHPLTFLTYPSNEKLINGF--ANNTYSVAVA 76

Query: 91 SDYTIDKMIKENLLNKLDKSKL 112
S Y + ++I+ +LL+ +D S+
Sbjct: 77 STYAVSELIERDLLSPIDWSQF 98


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0946HTHFIS673e-15 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 67.2 bits (164), Expect = 3e-15
Identities = 23/131 (17%), Positives = 50/131 (38%), Gaps = 2/131 (1%)

Query: 3 VLIIEDDPMVDFIHRNYLEKLNLFDRIISSDSMKAVQSILTDYAIDLILLDIHITDGNGI 62
+L+ +DD + + L + + + + + + DL++ D+ + D N
Sbjct: 6 ILVADDDAAIRTVLNQALSRAGY--DVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAF 63

Query: 63 QFLEKWRAQHIPCEVIIISAANDGNIIRDGFHLGIIDYLIKPFTFERFQESIQQFVTHRE 122
L + + V+++SA N G DYL KPF I + + +
Sbjct: 64 DLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPK 123

Query: 123 HLANQQLEQAQ 133
++ + +Q
Sbjct: 124 RRPSKLEDDSQ 134


12MGAS10270_Spy1006MGAS10270_Spy1018Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy1006-1143.101624hypothetical protein
MGAS10270_Spy1007-1133.326575Glucose inhibited division protein A
MGAS10270_Spy10081142.247776Na+ transporting oxaloacetate decarboxylase
MGAS10270_Spy10091131.813733hypothetical membrane associated protein
MGAS10270_Spy10101131.863178Biotin carboxyl carrier protein of oxaloacetate
MGAS10270_Spy10110132.142057Na+ transporting oxaloacetate decarboxylase beta
MGAS10270_Spy1012-1141.7207032'-(5''-triphosphoribosyl)-3-dephospho-CoA
MGAS10270_Spy10130171.526649Transcriptional regulator, GntR family
MGAS10270_Spy10140182.230399Mg2+/citrate complex secondary transporter
MGAS10270_Spy1015-1153.007237hypothetical protein
MGAS10270_Spy10160173.537677Biotin carboxyl carrier protein of oxaloacetate
MGAS10270_Spy1017-1183.055827Na+ transporting oxaloacetate decarboxylase beta
MGAS10270_Spy10180163.394292hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1006TYPE3IMSPROT320.002 Type III secretion system inner membrane S protein ...
		>TYPE3IMSPROT#Type III secretion system inner membrane S protein

family signature.
Length = 354

Score = 32.0 bits (73), Expect = 0.002
Identities = 14/75 (18%), Positives = 27/75 (36%), Gaps = 8/75 (10%)

Query: 172 TIGILERIVIGVCMIMG---QFASIGLVFTAKSIA-RYNKISESPAFAEYYLIGSLF--- 224
L ++ V +M G + + ++I KI+ + I SL
Sbjct: 82 EFFYLCFPLLTVAALMAIASHVVQYGFLISGEAIKPDIKKINPIEGAKRIFSIKSLVEFL 141

Query: 225 -SILSVFIAAWICFF 238
SIL V + + + +
Sbjct: 142 KSILKVVLLSILIWI 156


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1010RTXTOXIND270.024 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 26.7 bits (59), Expect = 0.024
Identities = 8/28 (28%), Positives = 14/28 (50%)

Query: 87 EILAPADGLVSKIHVVANQTVESEQVLI 114
EI + +V +I V ++V VL+
Sbjct: 98 EIKPIENSIVKEIIVKEGESVRKGDVLL 125



Score = 26.3 bits (58), Expect = 0.029
Identities = 13/40 (32%), Positives = 22/40 (55%)

Query: 51 VKAPMSGTVLSIFATEGKAVKKGEAVLVLEAMKMENEILA 90
+K + V I EG++V+KG+ +L L A+ E + L
Sbjct: 99 IKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLK 138


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1016RTXTOXIND300.004 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 29.8 bits (67), Expect = 0.004
Identities = 10/49 (20%), Positives = 22/49 (44%)

Query: 87 AIPSPMPGTILKVLVAVGDQVTENQPLLILEAMKMENEIVASSAGTITA 135
I + +++V G+ V + LL L A+ E + + + + + A
Sbjct: 98 EIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQA 146



Score = 27.1 bits (60), Expect = 0.035
Identities = 9/30 (30%), Positives = 13/30 (43%)

Query: 124 EIVASSAGTITAIHVGPGQVVNPGDGLITI 153
EI + I V G+ V GD L+ +
Sbjct: 98 EIKPIENSIVKEIIVKEGESVRKGDVLLKL 127


13MGAS10270_Spy1055MGAS10270_Spy1061Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy1055-319-3.017685Nucleoside transport ATP-binding protein
MGAS10270_Spy1056022-4.791762Nucleoside-binding protein
MGAS10270_Spy1057022-6.249797Cytidine deaminase
MGAS10270_Spy1058018-4.84316716S rRNA m(2)G 1207 methyltransferase
MGAS10270_Spy1059018-4.838682Pantothenate kinase
MGAS10270_Spy1060018-4.310261SSU ribosomal protein S20P
MGAS10270_Spy1061-116-3.984232Sensor protein ciaH
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1056LIPPROTEIN48664e-14 Mycoplasma P48 major surface lipoprotein signature.
		>LIPPROTEIN48#Mycoplasma P48 major surface lipoprotein signature.

Length = 428

Score = 65.8 bits (160), Expect = 4e-14
Identities = 76/299 (25%), Positives = 120/299 (40%), Gaps = 45/299 (15%)

Query: 36 DLKVAMVTDTGGVDDKSFNQSAWEGLQSWGKEMGLQKGTGFDYFQSTSESEYATNLDTAV 95
LK ++TD G +DDKSFNQSA+E L++ + K TG + S + + ++A+
Sbjct: 61 KLKPVLITDEGKIDDKSFNQSAFEALKA------INKQTGIEINNVEPSSNFESAYNSAL 114

Query: 96 SGGYQLIYGIGFALKDAIAKAAGD------NEGVKFVIIDDIIEGKDNV-ASVTFADHEA 148
S G+++ GF + +I + +K + ID IE + S+ F E+
Sbjct: 115 SAGHKIWVLNGFKHQQSIKQYIDAHREELERNQIKIIGIDFDIETEYKWFYSLQFNIKES 174

Query: 149 AYLAGIAAAKTTKTK-----TVGFVGGMEGTVITRFEKGFEAGVKS---------VDDTI 194
A+ G A A + V GG +T F +GF G+ + T
Sbjct: 175 AFTTGYAIASWLSEQDESKRVVASFGGGAFPGVTTFNEGFAKGILYYNQKHKSSKIYHTS 234

Query: 195 QVKVDYAGSFGDAAKGKTIAAAQYAAGADVIYQAAGG---TGAGVFNEAKAINEKRSEAD 251
VK+D +G I + ADV Y G F + N+ +
Sbjct: 235 PVKLD-SGFTAGEKMNTVINNVLSSTPADVKYNPHVILSVAGPATFETVRLANKGQ---- 289

Query: 252 KVWVIGVDRDQKDEGKYTSKDGKEANFVLASSIKEVGKAVQLINKQVADKKFPGGKTTV 310
+VIGVD DQ +D +L S +K + +AV + +K G K V
Sbjct: 290 --YVIGVDSDQG-----MIQDKDR---ILTSVLKHIKQAVYETLLDLILEKEEGYKPYV 338


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1061PF06580392e-05 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 39.1 bits (91), Expect = 2e-05
Identities = 15/75 (20%), Positives = 31/75 (41%), Gaps = 5/75 (6%)

Query: 312 YGKIFYFQNQVNRSLRMDKALLKQLITILFDNAIKY----TDKNGIIEIIVKTTDKNLLI 367
+ F+NQ+N ++ D + L+ L +N IK+ + G I + + + +
Sbjct: 236 FEDRLQFENQINPAIM-DVQVPPMLVQTLVENGIKHGIAQLPQGGKILLKGTKDNGTVTL 294

Query: 368 SVIDNGPGITDEEKK 382
V + G K+
Sbjct: 295 EVENTGSLALKNTKE 309


14MGAS10270_Spy1078MGAS10270_Spy1085Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy1078216-0.244054Integral membrane protein
MGAS10270_Spy1079216-0.396499Type I restriction-modification system
MGAS10270_Spy1080016-0.889698ABC transporter permease protein
MGAS10270_Spy1081-118-2.160667ABC transporter ATP-binding protein
MGAS10270_Spy1082220-4.011298Transcriptional regulator, TetR family
MGAS10270_Spy1083123-4.756780hypothetical protein
MGAS10270_Spy1084-121-4.910303NAD-dependent K+ or Na+ uptake system component
MGAS10270_Spy1085023-4.121653General stress protein, Gls24 family
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1081PF05272348e-04 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 33.5 bits (76), Expect = 8e-04
Identities = 18/41 (43%), Positives = 23/41 (56%), Gaps = 2/41 (4%)

Query: 36 KGELVVIL-GASGAGKSTVLNILGGMD-TVDAGQVIIDGKD 74
K + V+L G G GKST++N L G+D D I GKD
Sbjct: 594 KFDYSVVLEGTGGIGKSTLINTLVGLDFFSDTHFDIGTGKD 634


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1082HTHTETR415e-07 TetR bacterial regulatory protein HTH signature.
		>HTHTETR#TetR bacterial regulatory protein HTH signature.

Length = 215

Score = 41.2 bits (96), Expect = 5e-07
Identities = 13/48 (27%), Positives = 25/48 (52%)

Query: 4 RHTETKAYVKTALTTLLTEQSFETLTVSDLTKKAGINRGTFYLHYTDK 51
ET+ ++ L ++Q + ++ ++ K AG+ RG Y H+ DK
Sbjct: 8 EAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDK 55


15MGAS10270_Spy1163MGAS10270_Spy1168Y        NNGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy1163-1194.378739Mag protein precursor
MGAS10270_Spy1164-1214.780718Beta-N-acetylhexosaminidase
MGAS10270_Spy1165-1204.460139Beta-N-acetylhexosaminidase
MGAS10270_Spy1166-1184.154595Beta-N-acetylhexosaminidase
MGAS10270_Spy1167-1173.692647Beta-N-acetylhexosaminidase
MGAS10270_Spy1168-2143.291385Phosphoglycolate phosphatase
16MGAS10270_Spy1274MGAS10270_Spy1309Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy1274417-3.270155hypothetical cytosolic protein
MGAS10270_Spy1275216-2.722797Non-specific DNA-binding protein Dps /
MGAS10270_Spy1276219-2.740645Type 4 prepilin peptidase pilD
MGAS10270_Spy1277018-2.493229Radical SAM family enzyme
MGAS10270_Spy1278018-2.469394hypothetical cytosolic protein
MGAS10270_Spy1279-116-0.949631hypothetical protein
MGAS10270_Spy1280-2140.087542Ribose operon repressor
MGAS10270_Spy1281-2141.088557ATP-dependent endopeptidase Lon
MGAS10270_Spy12821141.491491Phosphopantetheine adenylyltransferase
MGAS10270_Spy12832172.153142Methyltransferase
MGAS10270_Spy12843182.292136Aspartate--ammonia ligase
MGAS10270_Spy12853232.133479Carbamate kinase
MGAS10270_Spy12861201.356767Xaa-His dipeptidase
MGAS10270_Spy12872231.036169Arginine/ornithine antiporter
MGAS10270_Spy12882221.228892Ornithine carbamoyltransferase
MGAS10270_Spy1289-1151.022596Acetyltransferase
MGAS10270_Spy1290-2181.938268Arginine deiminase
MGAS10270_Spy1291-3191.909648Transcription regulator, crp family
MGAS10270_Spy1292-3202.650797Arginine repressor, argR
MGAS10270_Spy1293-3201.879054hypothetical protein
MGAS10270_Spy12940191.044269hypothetical cytosolic protein
MGAS10270_Spy1295-119-1.225539Two-component sensor kinase yesM
MGAS10270_Spy1296019-5.133990Two-component response regulator yesN
MGAS10270_Spy1297321-6.368859phage protein
MGAS10270_Spy1298221-6.176698hypothetical protein
MGAS10270_Spy1299-117-2.661584hypothetical protein
MGAS10270_Spy1300-117-2.382624Exotoxin type C precursor
MGAS10270_Spy1301119-0.595297phage protein
MGAS10270_Spy13021221.947463phage protein
MGAS10270_Spy13033252.266139N-acetylmuramoyl-L-alanine amidase
MGAS10270_Spy13045263.478297phage-associated cell wall hydrolase
MGAS10270_Spy13055252.414586Holin
MGAS10270_Spy13064262.883227phage protein
MGAS10270_Spy13073262.919512phage protein
MGAS10270_Spy13082213.334624phage protein
MGAS10270_Spy13092213.371594phage infection protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1275HELNAPAPROT1511e-49 Helicobacter neutrophil-activating protein A family ...
		>HELNAPAPROT#Helicobacter neutrophil-activating protein A family

signature.
Length = 153

Score = 151 bits (383), Expect = 1e-49
Identities = 49/154 (31%), Positives = 85/154 (55%), Gaps = 4/154 (2%)

Query: 19 KKEASKNEKT--KAVLNQAVADLSVAASIVHQVHWYMRGPGFLYLHPKMDELLDSLNANL 76
K E +K +T + LN +++ + S +H+ HWY++GP F LH K +EL D +
Sbjct: 2 KTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFFTLHEKFEELYDHAAETV 61

Query: 77 DEMSERLITIGGAPYSTLAEFSKHSKLDEAKGTYDKTVAQHLARLVEVYLYLSSLYQVGL 136
D ++ERL+ IGG P +T+ E+++H+ + + + + ++ + LV Y +SS + +
Sbjct: 62 DTIAERLLAIGGQPVATVKEYTEHASITDGGN--ETSASEMVQALVNDYKQISSESKFVI 119

Query: 137 DITDEEGDAGTNDLFTAAKTEAEKTIWMLQAERG 170
+ +E D T DLF E EK +WML + G
Sbjct: 120 GLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG 153


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1276PREPILNPTASE290.009 Type IV prepilin cysteine protease (C20) family sig...
		>PREPILNPTASE#Type IV prepilin cysteine protease (C20) family

signature.
Length = 290

Score = 29.4 bits (66), Expect = 0.009
Identities = 42/160 (26%), Positives = 59/160 (36%), Gaps = 25/160 (15%)

Query: 70 SLIIILWASMVHWVSASYCYLLLFSLLFSLF--DWRSQ------EYPFILWLFSFVSLLL 121
+L+ + A + + LLL +L +L D P + F L
Sbjct: 118 ALLSVAVAMTLAPGWGTLAALLLTWVLVALTFIDLDKMLLPDQLTLPLLWGGLLFNLLGG 177

Query: 122 FYSIN---------YLSLILLLLGLLAHLRPFSIGAGDFFYLASLALVLDLTSLIWLIQL 172
F S+ YL L L +G GDF LA+L L +L ++ L
Sbjct: 178 FVSLGDAVIGAMAGYLVLWSLYWAFKLLTGKEGMGYGDFKLLAALGAWLGWQALPIVLLL 237

Query: 173 ASLAGITACLLL-------GIKRIPFIPYLSFGLFWIVLL 205
+SL G + L K IPF PYL+ WI LL
Sbjct: 238 SSLVGAFMGIGLILLRNHHQSKPIPFGPYLAIA-GWIALL 276


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1280HTHTETR337e-04 TetR bacterial regulatory protein HTH signature.
		>HTHTETR#TetR bacterial regulatory protein HTH signature.

Length = 215

Score = 33.4 bits (76), Expect = 7e-04
Identities = 9/34 (26%), Positives = 19/34 (55%)

Query: 8 KLILQGGKAMVTIKQVAEEAGVSRSTVSRYISQK 41
+L Q G + ++ ++A+ AGV+R + + K
Sbjct: 22 RLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDK 55


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1282LPSBIOSNTHSS1532e-50 Lipopolysaccharide core biosynthesis protein signat...
		>LPSBIOSNTHSS#Lipopolysaccharide core biosynthesis protein

signature.
Length = 166

Score = 153 bits (389), Expect = 2e-50
Identities = 58/157 (36%), Positives = 94/157 (59%), Gaps = 2/157 (1%)

Query: 5 IGLYTGSFDPVTNGHLDIVKRASGLFDQIYVGIFDNPTKKSYFKLEVRKAMLTQALADFT 64
+Y GSFDP+T GHLDI++R LFDQ+YV + NP K+ F ++ R + +A+A
Sbjct: 2 NAIYPGSFDPITFGHLDIIERGCRLFDQVYVAVLRNPNKQPMFSVQERLEQIAKAIAHLP 61

Query: 65 NVIVVTSHERLAIDVAKELRVTHLIRGLRNATDFEYEENLEYFNHLLAPNIETVYLISRN 124
N V + E L ++ A++ + ++RGLR +DFE E + N LA ++ETV+L +
Sbjct: 62 NAQVDSF-EGLTVNYARQRQAGAILRGLRVLSDFELELQMANTNKTLASDLETVFLTTST 120

Query: 125 KWQALSSSRVRELIHFQSSLEDLVPQSVIAQV-EKMN 160
++ LSSS V+E+ F ++E VP V A + ++ +
Sbjct: 121 EYSFLSSSLVKEVARFGGNVEHFVPSHVAAALYDQFH 157


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1285CARBMTKINASE405e-145 Bacterial carbamate kinase signature.
		>CARBMTKINASE#Bacterial carbamate kinase signature.

Length = 314

Score = 405 bits (1043), Expect = e-145
Identities = 141/315 (44%), Positives = 204/315 (64%), Gaps = 6/315 (1%)

Query: 3 KQKIVVALGGNAIL--STDASAKAQQEALISTSKSLVKLIKEGHEVIVTHGNGPQVGNLL 60
+++V+ALGGNA+ S + + + T++ + ++I G+EV++THGNGPQVG+LL
Sbjct: 2 GKRVVIALGGNALQQRGQKGSYEEMMDNVRKTARQIAEIIARGYEVVITHGNGPQVGSLL 61

Query: 61 LQQAAADSEKN-PAMPLDTCVAMTEGSIGFWLVNALDNELQAQGIQKEVAAVVTQVIVDA 119
L A + PA P+D AM++G IG+ + AL NEL+ +G++K+V ++TQ IVD
Sbjct: 62 LHMDAGQATYGIPAQPMDVAGAMSQGWIGYMIQQALKNELRKRGMEKKVVTIITQTIVDK 121

Query: 120 KDPAFENPTKPIGPFLTEEDAKKQMAESGASFKEDAGRGWRKVVPSPKPVGIKEANVIRS 179
DPAF+NPTKP+GPF EE AK+ E G KED+GRGWR+VVPSP P G EA I+
Sbjct: 122 NDPAFQNPTKPVGPFYDEETAKRLAREKGWIVKEDSGRGWRRVVPSPDPKGHVEAETIKK 181

Query: 180 LVDSGVVVVSAGGGGVPVVEDATSKTLTGVEAVIDKDFASQTLSELVDADLFIVLTGVDN 239
LV+ GV+V+++GGGGVPV+ + + GVEAVIDKD A + L+E V+AD+F++LT V+
Sbjct: 182 LVERGVIVIASGGGGVPVILED--GEIKGVEAVIDKDLAGEKLAEEVNADIFMILTDVNG 239

Query: 240 VYVNFNKPDQAKLEEVTVSQMKEYITQDQFAPGSMLPKVEAAIAFVENKPNAKAIITSLE 299
+ + + L EV V ++++Y + F GSM PKV AAI F+E +AII LE
Sbjct: 240 AALYYGTEKEQWLREVKVEELRKYYEEGHFKAGSMGPKVLAAIRFIEW-GGERAIIAHLE 298

Query: 300 NIDNVLSANAGTQII 314
L GTQ++
Sbjct: 299 KAVEALEGKTGTQVL 313


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1290ARGDEIMINASE5770.0 Bacterial arginine deiminase signature.
		>ARGDEIMINASE#Bacterial arginine deiminase signature.

Length = 409

Score = 577 bits (1490), Expect = 0.0
Identities = 191/410 (46%), Positives = 276/410 (67%), Gaps = 9/410 (2%)

Query: 5 TPIHVYSEIGKLKKVLLHRPGKEIENLMPDYLERLLFDDIPFLEDAQKEHDAFAQALRDE 64
PI+++SEIG+LKKVLLHRPG+E+ENL P ++ LFDDIP+LE A++EH+ FA L++
Sbjct: 6 NPINIFSEIGRLKKVLLHRPGEELENLTPFIMKNFLFDDIPYLEVARQEHEVFASILKNN 65

Query: 65 GIEVLYLETLAAESLVTP-EIREAFIDEYLSEANIRGRATKKAIRELLMAIEDNQELIEK 123
+E+ Y+E L +E LV+ + FI +++ EA I+ T +++ ++ +I K
Sbjct: 66 LVEIEYIEDLISEVLVSSVALENKFISQFILEAEIKTDFTINLLKDYFSSL-TIDNMISK 124

Query: 124 TMAGVQKSELPEIPASEKGLTDLVESNYPFAIDPMPNLYFTRDPFATIGTGVSLNHMFSE 183
++GV EL +S L DLV F IDPMPN+ FTRDPFA+IG GV++N MF++
Sbjct: 125 MISGVVTEELKNYTSS---LDDLVNGANLFIIDPMPNVLFTRDPFASIGNGVTINKMFTK 181

Query: 184 TRNRETLYGKYIFTHHPIYGGGKVPMVYDRNETTRIEGGDELVLSKDVLAVGISQRTDAA 243
R RET++ +YIF +HP+Y VP+ +R E +EGGDELVL+K +L +GIS+RT+A
Sbjct: 182 VRQRETIFAEYIFKYHPVYKE-NVPIWLNRWEEASLEGGDELVLNKGLLVIGISERTEAK 240

Query: 244 SIEKLLVNIFKQNLGFKKVLAFEFANNRKFMHLDTVFTMVDYDKFTIHPEIEGDLRVYSV 303
S+EKL +++FK F +LAF+ NR +MHLDTVFT +DY FT + +Y +
Sbjct: 241 SVEKLAISLFKNKTSFDTILAFQIPKNRSYMHLDTVFTQIDYSVFTSFTSDDMYFSIYVL 300

Query: 304 TYDNE--ELHIIEEKGDLAELLAANLGVEKVDLIRCGGDNLVAAGREQWNDGSNTLTIAP 361
TY+ ++HI +EK + ++L+ LG K+D+I+C G +L+ REQWNDG+N L IAP
Sbjct: 301 TYNPSSSKIHIKKEKARIKDVLSFYLG-RKIDIIKCAGGDLIHGAREQWNDGANVLAIAP 359

Query: 362 GVVVVYNRNTITNAILESKGLKLIKIHGSELVRGRGGPRCMSMPFEREDI 411
G ++ Y+RN +TN + E G+K+ +I SEL RGRGGPRCMSMP REDI
Sbjct: 360 GEIIAYSRNHVTNKLFEENGIKVHRIPSSELSRGRGGPRCMSMPLIREDI 409


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1292ARGREPRESSOR1242e-39 Bacterial arginine repressor signature.
		>ARGREPRESSOR#Bacterial arginine repressor signature.

Length = 149

Score = 124 bits (314), Expect = 2e-39
Identities = 61/146 (41%), Positives = 92/146 (63%), Gaps = 2/146 (1%)

Query: 1 MNKKETRHQLIRSLISETTIHTQQELQERLQKNGITITQATLSRDMKELNLVKVTSGNDT 60
MNK + RH IR +I+ I TQ EL + L+K+G +TQAT+SRD+KEL+LVKV + N +
Sbjct: 1 MNKGQ-RHIKIREIITANEIETQDELVDILKKDGYNVTQATVSRDIKELHLVKVPTNNGS 59

Query: 61 HYEALAISQTRWEH-RLRFYMEDALVMLKIVQHQIILKTLPGLAQSFGSILDAMQIPEIV 119
+ +L Q +L+ + DA V + H I+LKT+PG AQ+ G+++D + EI+
Sbjct: 60 YKYSLPADQRFNPLSKLKRSLMDAFVKIDSASHLIVLKTMPGNAQAIGALMDNLDWEEIM 119

Query: 120 ATICGDDTCLIVCEDNEQAKACYETL 145
TICGDDT LI+C ++ K + +
Sbjct: 120 GTICGDDTILIICRTHDDTKVVQKKI 145


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1295PF065801812e-54 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 181 bits (462), Expect = 2e-54
Identities = 57/203 (28%), Positives = 100/203 (49%), Gaps = 10/203 (4%)

Query: 362 EKAIGQYRLQALASQINPHFLYNTLDTIIWMAEFNDSKRVVEVTKSLAKYFRLALNQGN- 420
+ +L AL +QINPHF++N L+ I + D + E+ SL++ R +L N
Sbjct: 155 ASMAQEAQLMALKAQINPHFMFNALNNIRALIL-EDPTKAREMLTSLSELMRYSLRYSNA 213

Query: 421 EYIRLADELDHVSQYLFIQKQRYGDKLSYEVQGLDVYADFVIPKLILQPLVENAIYHGIK 480
+ LADEL V YL + ++ D+L +E Q D +P +++Q LVEN I HGI
Sbjct: 214 RQVSLADELTVVDSYLQLASIQFEDRLQFENQINPAIMDVQVPPMLVQTLVENGIKHGIA 273

Query: 481 EVDRKGMIKVTVSDTAQHLVLTVWDNGKGIEDSSLTNSQSLLARGGVGLKNVDQRLKLHY 540
++ + G I + + + L V + G ++ ++ G GL+NV +RL++ Y
Sbjct: 274 QLPQGGKILLKGTKDNGTVTLEVENTGSLALKNTKEST-------GTGLQNVRERLQMLY 326

Query: 541 GKGYHMTIHSQSDHFTEIQLSLP 563
G + + + + + +P
Sbjct: 327 GTEAQIKLSEKQGKVNAM-VLIP 348


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1296HTHFIS935e-24 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 93.4 bits (232), Expect = 5e-24
Identities = 41/165 (24%), Positives = 74/165 (44%), Gaps = 12/165 (7%)

Query: 3 SLLIVEDEYLVRQGIRSLVDFSQFKIDRVNEAENGQLAWDLFQKEPYDIVLTDINMPKLN 62
++L+ +D+ +R + + + + V N W D+V+TD+ MP N
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGY---DVRITSNAATLWRWIAAGDGDLVVTDVVMPDEN 61

Query: 63 GIQLAELIKQESPQTHLVFLTGYDDFNYALSALRLGADDYLLKPFSKADVEDMLGKLRKK 122
L IK+ P ++ ++ + F A+ A GA DYL KPF D+ +++G + +
Sbjct: 62 AFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPF---DLTELIGIIGRA 118

Query: 123 LELSKKTETIQELVEQPQKEVSAIAMAIHE------QLADSDLTL 161
L K+ + E Q + + A+ E +L +DLTL
Sbjct: 119 LAEPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTL 163


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1300BACTRLTOXIN465e-08 Bacterial toxin signature.
		>BACTRLTOXIN#Bacterial toxin signature.

Length = 266

Score = 45.7 bits (108), Expect = 5e-08
Identities = 44/222 (19%), Positives = 85/222 (38%), Gaps = 36/222 (16%)

Query: 61 LKEIYN-KEIIEKNNISINAKQGTQLIFNTDENTTVWNDNTFKKVISSNLSPSQERMFNV 119
+K +Y+ + S++ LI+N + D KV + L+ + +
Sbjct: 51 MKYLYDDHYVSATKVKSVDKFLAHDLIYNISDKKLKNYD----KVKTELLNEDLAKKYK- 105

Query: 120 GDHVNIFAIVKSYHVVCKEQFNYSD---------GGIIKTSDVKPEE---KAIYINIFGE 167
+ V+++ + + N GGI K + + + + ++
Sbjct: 106 DEVVDVYGSNYYVNCYFSSKDNVGKVTGGKTCMYGGITKHEGNHFDNGNLQNVLVRVYEN 165

Query: 168 KELRTLTAKDKITFKNNIVTLQEIDVRLRKSLMGDSKIKLYEYD-SLYKKGFWDIHYKDG 226
K T ++ VT QE+D++ R L+ +K LYE++ S Y+ G+ +G
Sbjct: 166 KRN---TISFEVQTDKKSVTAQELDIKARNFLI--NKKNLYEFNSSPYETGYIKFIENNG 220

Query: 227 GIRHTNLFTYPD-----------YTDNETIDMSKVSHFDVHL 257
++ P Y DN+T+D SK +VHL
Sbjct: 221 NTFWYDMMPAPGDKFDQSKYLMMYNDNKTVD-SKSVKIEVHL 261


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1304FLGFLGJ976e-25 Flagellar protein FlgJ signature.
		>FLGFLGJ#Flagellar protein FlgJ signature.

Length = 313

Score = 96.7 bits (240), Expect = 6e-25
Identities = 46/123 (37%), Positives = 65/123 (52%), Gaps = 8/123 (6%)

Query: 23 SLTAAQAILESGWGKHA-------PHNALFGIKADASWTGKSFNTKTQEEYQAGVITDIV 75
L AQA LESGWG+ P LFG+KA +W G T E Y+ G +
Sbjct: 172 HLILAQAALESGWGQRQIRRENGEPSYNLFGVKASGNWKGPVTEITTTE-YENGEAKKVK 230

Query: 76 DRFRAYDSWDESIADHGQFLVDNPRYQSVIGEADYKKACHAIKDAGYATASGYAELLIQI 135
+FR Y S+ E+++D+ L NPRY +V A ++ A++DAGYAT YA L +
Sbjct: 231 AKFRVYSSYLEALSDYVGLLTRNPRYAAVTTAASAEQGAQALQDAGYATDPHYARKLTNM 290

Query: 136 IEE 138
I++
Sbjct: 291 IQQ 293


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1309RTXTOXIND340.003 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 33.6 bits (77), Expect = 0.003
Identities = 27/145 (18%), Positives = 51/145 (35%), Gaps = 21/145 (14%)

Query: 158 RLSSSYQSGINGLKAQLANDKI---GLQAEIQATAQGLSQKYDNELRQLSAKITTTSSGT 214
RL+S + + + Q ++ +AE T +Y+N R +++ SS
Sbjct: 186 RLTSLIKEQFSTWQNQKYQKELNLDKKRAERL-TVLARINRYENLSRVEKSRLDDFSSLL 244

Query: 215 TEAYESKLAGLRAEFTRSNQGMRIELESQISGLRAVQQSTASQISQEIRDRTGAVSRVQQ 274
+ +K A L E E++ + SQ+ Q + A Q
Sbjct: 245 HKQAIAKHAVL-------------EQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQL 291

Query: 275 DLESYQR----RLQDAEDNYSSLTH 295
+ ++ +L+ DN LT
Sbjct: 292 VTQLFKNEILDKLRQTTDNIGLLTL 316


17MGAS10270_Spy1320MGAS10270_Spy1355Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy13202221.071197phage protein
MGAS10270_Spy13213231.350001Major head protein
MGAS10270_Spy13223220.991988phage protein
MGAS10270_Spy13234220.837562phage protein
MGAS10270_Spy13244220.283682phage protein
MGAS10270_Spy13253230.047738Minor capsid protein
MGAS10270_Spy1326222-0.795237Minor capsid protein
MGAS10270_Spy1327122-1.463570Terminase large subunit
MGAS10270_Spy1328325-2.343623phage protein
MGAS10270_Spy1329025-2.365009phage transcriptional regulator
MGAS10270_Spy1330022-0.481076hypothetical amino acid ABC transporter
MGAS10270_Spy13310240.553032Chromosome partitioning protein parB
MGAS10270_Spy13322281.247638phage protein
MGAS10270_Spy1333226-1.010611phage protein
MGAS10270_Spy1334124-1.430610phage encoded transcriptional regulator, ArpU
MGAS10270_Spy1335125-1.980910phage protein
MGAS10270_Spy1336123-2.971376phage protein
MGAS10270_Spy1337122-2.489489phage protein
MGAS10270_Spy1338026-1.548440phage protein
MGAS10270_Spy13393280.805109phage protein
MGAS10270_Spy1340427-0.007331phage protein
MGAS10270_Spy1341524-0.626744phage protein
MGAS10270_Spy1342526-0.344631phage protein
MGAS10270_Spy1343527-0.124243phage protein
MGAS10270_Spy1344725-0.916111phage single-strand DNA binding protein
MGAS10270_Spy1345827-1.983019phage single-strand DNA binding protein
MGAS10270_Spy1346929-1.861517phage protein
MGAS10270_Spy1347835-1.120448phage protein
MGAS10270_Spy1348831-2.204690phage protein
MGAS10270_Spy1349832-2.080644phage protein
MGAS10270_Spy1350732-1.646644DNA replication protein dnaD
MGAS10270_Spy1351426-0.998559phage replication protein
MGAS10270_Spy1352226-1.534121phage protein
MGAS10270_Spy1353225-1.392376phage protein
MGAS10270_Spy1354224-1.272607phage protein
MGAS10270_Spy1355323-3.313119phage protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1332TYPE3OMBPROT280.003 Type III secretion system outer membrane B protein ...
		>TYPE3OMBPROT#Type III secretion system outer membrane B protein

family signature.
Length = 538

Score = 28.5 bits (63), Expect = 0.003
Identities = 12/29 (41%), Positives = 16/29 (55%)

Query: 1 MWLADSSVEDSAEVSCCTVHGVISYRGLK 29
MWL+ ++ E+ HGVIS GLK
Sbjct: 206 MWLSKVVDDEGKEIFSGIRHGVISAYGLK 234


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1346ANTHRAXTOXNA280.026 Anthrax toxin LF subunit signature.
		>ANTHRAXTOXNA#Anthrax toxin LF subunit signature.

Length = 800

Score = 27.8 bits (61), Expect = 0.026
Identities = 23/89 (25%), Positives = 40/89 (44%), Gaps = 1/89 (1%)

Query: 71 QAEAKVEKYKETIRRAMELSQKKKVDAGMFKVSLRKSKKVEILDETKIPLDYMQEKIEYK 130
+ A E Y E+ + ++K K + FK S+ K E +ET + Q+ ++
Sbjct: 30 EVNAMNEHYTESDIKRNHKTEKNKTEKEKFKDSINNLVKTEFTNETLDKIQQTQDLLKKI 89

Query: 131 PMKS-EISKALKSGIDISGVELIETESLQ 158
P EI L I + ++L+E + LQ
Sbjct: 90 PKDVLEIYSELGGEIYFTDIDLVEHKELQ 118


18MGAS10270_Spy1374MGAS10270_Spy1439Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy1374221-4.864443hypothetical protein
MGAS10270_Spy1375430-7.982581Ribosomal-protein-serineacetyltransferase
MGAS10270_Spy1376329-6.940229hypothetical cytosolic protein
MGAS10270_Spy1377132-7.633433hypothetical protein
MGAS10270_Spy1378028-5.072609*DNA integration/recombination/inversion protein
MGAS10270_Spy1379024-3.220688hypothetical protein
MGAS10270_Spy1380-121-3.743604hypothetical membrane spanning protein
MGAS10270_Spy1381-119-2.760627Cell surface protein
MGAS10270_Spy1382-119-3.363369hypothetical protein
MGAS10270_Spy1383-118-3.198866hypothetical protein
MGAS10270_Spy1384020-4.716826hypothetical protein
MGAS10270_Spy1385-121-4.934103Membrane protein
MGAS10270_Spy1386023-4.558104DNA segregation ATPase
MGAS10270_Spy1387126-5.782144hypothetical protein
MGAS10270_Spy1388127-5.544642hypothetical membrane spanning protein
MGAS10270_Spy1389129-6.530832hypothetical protein
MGAS10270_Spy1390330-7.108225hypothetical protein
MGAS10270_Spy1391228-6.930557hypothetical protein
MGAS10270_Spy1392128-6.938526hypothetical protein
MGAS10270_Spy1393127-6.611852hypothetical protein
MGAS10270_Spy1394-419-1.897140hypothetical cytosolic protein
MGAS10270_Spy1395017-0.643720Transcriptional regulator, Cro/CI family
MGAS10270_Spy1396116-0.083918FtsK/SpoIIIE family
MGAS10270_Spy13973150.920875hypothetical cytosolic protein
MGAS10270_Spy13983150.773256hypothetical cytosolic protein
MGAS10270_Spy13993150.293317Cell surface protein
MGAS10270_Spy1400521-3.358225M protein
MGAS10270_Spy1401328-9.567630hypothetical cytosolic protein
MGAS10270_Spy1402328-9.531026Glutaredoxin-like protein
MGAS10270_Spy1403530-9.922046Transcriptional regulator, Cro/CI family
MGAS10270_Spy1404230-9.856351Transcriptional regulator, Cro/CI family
MGAS10270_Spy1405231-3.867610hypothetical cytosolic protein
MGAS10270_Spy1406429-4.189136hypothetical protein
MGAS10270_Spy1407224-2.900929hypothetical cytosolic protein
MGAS10270_Spy1408019-1.430610DNA-damage-inducible protein J
MGAS10270_Spy1409018-1.066692Transposase
MGAS10270_Spy1410018-0.979611Cell surface protein
MGAS10270_Spy1411-117-1.005768Transcriptional regulator, AraC family
MGAS10270_Spy1412-2182.2509753-deoxy-7-phosphoheptulonate synthase
MGAS10270_Spy1413-2173.3868623-dehydroquinate synthase
MGAS10270_Spy14141204.379984hypothetical protein
MGAS10270_Spy14152183.486658Putative acetate kinase
MGAS10270_Spy14162193.620927hypothetical cytosolic protein
MGAS10270_Spy14171193.310193SAM-dependent methyltransferase
MGAS10270_Spy14181202.960412Shikimate 5-dehydrogenase
MGAS10270_Spy14191162.117480Beta-galactosidase
MGAS10270_Spy14200170.247972Two-component response regulator yesN
MGAS10270_Spy14210160.348931Two-component sensor kinase yesM
MGAS10270_Spy1422-1180.977178Two-component sensor kinase yesM
MGAS10270_Spy14232190.900620hypothetical membrane spanning protein
MGAS10270_Spy14241172.305703Sugar-binding protein
MGAS10270_Spy14250183.029777Sugar transport system permease protein
MGAS10270_Spy14260173.256790Sugar transport system permease protein
MGAS10270_Spy1427-1174.082736Glucokinase / transcription regulator
MGAS10270_Spy1428-1174.370853hypothetical protein
MGAS10270_Spy1429-2152.808630Beta-glucosidase
MGAS10270_Spy1430-3162.453104Hyaluronoglucosaminidase
MGAS10270_Spy1431-3151.800157Transcriptional regulator, GntR family /
MGAS10270_Spy1432-3161.422865hypothetical protein
MGAS10270_Spy1433-4150.850280Alpha-mannosidase
MGAS10270_Spy1434-316-2.058541Sensory transduction protein kinase
MGAS10270_Spy1435-119-0.138749tRNA (Uracil-5-) -methyltransferase
MGAS10270_Spy1436220-2.710077Regulatory protein recX
MGAS10270_Spy1437619-3.573445hypothetical cytosolic protein
MGAS10270_Spy1438119-3.257383hypothetical protein
MGAS10270_Spy1439119-3.628409Transposase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1385TYPE3IMRPROT320.006 Type III secretion system inner membrane R protein ...
		>TYPE3IMRPROT#Type III secretion system inner membrane R protein

family signature.
Length = 261

Score = 32.4 bits (74), Expect = 0.006
Identities = 19/88 (21%), Positives = 33/88 (37%), Gaps = 5/88 (5%)

Query: 290 FEAVILAIPLLLIQLIAFLADIVVILLMFLFPLALLVSFLPKMQHIAFNM-LKLMLG--- 345
F A+ A L+ + + ++ +LL L LL P++ L L +G
Sbjct: 169 FLALTKAGSLIFLNGLMLALPLITLLLTLNLALGLLNRMAPQLSIFVIGFPLTLTVGISL 228

Query: 346 -GVSFPALTGFLTLIVFYIQSLIATFIK 372
P + F + I +L+A I
Sbjct: 229 MAALMPLIAPFCEHLFSEIFNLLADIIS 256



Score = 31.3 bits (71), Expect = 0.012
Identities = 22/144 (15%), Positives = 51/144 (35%), Gaps = 16/144 (11%)

Query: 267 QNRWMSAVSDYIWIKSIYVILKIFEAVILAIPLLLIQLIAFLADIVVILLMFLFPLALLV 326
+W+S ++ Y W +L++ A+I P+L + + + + +++ L
Sbjct: 6 SEQWLSWLNLYFW-----PLLRVL-ALISTAPILSERSVPKRVKLGLAMMITFAIAPSLP 59

Query: 327 SFLPKMQHIAFNMLKLMLGGVSFPALTGFLTLIVFYIQSLIATFIK-------SRFTDNH 379
+ + +F L L + + GF F I + F D
Sbjct: 60 ANDVPV--FSFFALWLAVQQILIGIALGFTMQFAFAAVRTAGEIIGLQMGLSFATFVDPA 117

Query: 380 LLSSSNLKGQSILFMLFITIVVQG 403
+ + + I+ ML + + +
Sbjct: 118 SHLNMPVLAR-IMDMLALLLFLTF 140


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1388TYPE3IMSPROT260.015 Type III secretion system inner membrane S protein ...
		>TYPE3IMSPROT#Type III secretion system inner membrane S protein

family signature.
Length = 354

Score = 26.3 bits (58), Expect = 0.015
Identities = 10/73 (13%), Positives = 26/73 (35%), Gaps = 11/73 (15%)

Query: 18 VSGLKQFFQGDGIY----------LISVICAFLVIKNWKNADWLKVGSVLSIYAIVVSLF 67
+ G K+ F + L+S++ ++ N L + I ++ +
Sbjct: 125 IEGAKRIFSIKSLVEFLKSILKVVLLSILIWIIIKGNLVTLLQLPTCGIECITPLLGQIL 184

Query: 68 KGQEILAFLGGML 80
+ Q ++ G +
Sbjct: 185 R-QLMVICTVGFV 196


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1391TACYTOLYSIN270.009 Bacterial thiol-activated pore-forming cytolysin sig...
		>TACYTOLYSIN#Bacterial thiol-activated pore-forming cytolysin

signature.
Length = 574

Score = 26.9 bits (59), Expect = 0.009
Identities = 10/27 (37%), Positives = 13/27 (48%)

Query: 39 FNELGSEGVGKENMELYFDCEAYGRDI 65
EL +GV E L+ AYGR +
Sbjct: 325 LKELQRKGVSNEAPPLFVSNVAYGRTV 351


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1399GPOSANCHOR651e-12 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 65.1 bits (158), Expect = 1e-12
Identities = 76/384 (19%), Positives = 158/384 (41%), Gaps = 44/384 (11%)

Query: 106 THDSLSSAQADLEKQTQAVTEATTKQEANTTAINQAVSENKAIDQANRDEKARVDALNTK 165
+ +L +L ++ E K N ++++ S+ + ++ D + ++
Sbjct: 79 NNKALKDHNDELTEELSNAKE---KLRKNDKSLSEKASKIQELEARKADLEKALEGAMNF 135

Query: 166 GEADTKAKN--ETGQAQVDAQNKQAQAAADAMNAKLKADYEAKLTEIKQIESENEAIRQR 223
AD+ E +A + A+ + A + AD AK+ ++ ++ EA +
Sbjct: 136 STADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTAD-SAKIKTLEAEKAALEARQAE 194

Query: 224 NQQASQATHQANQAAQAAYQEKLAEIERIKAENAAIRDRNAKAQQEAERQNQALQAAYEA 283
++A + + A A + AE + A A + KA + A + A A +
Sbjct: 195 LEKALEGAMNFSTADSAKIKTLEAEKAALAARKADL----EKALEGAMNFSTADSAKIKT 250

Query: 284 KLAEIKQIESENAAIRQRNEQAGQATNQTNQAAQAAYQEKLAEIERIKAGNAAIRDRNAK 343
AE +E+ A + + E A + A A + AE ++A A + ++
Sbjct: 251 LEAEKAALEARQAELEKALEGA----MNFSTADSAKIKTLEAEKAALEAEKADLEHQSQV 306

Query: 344 AQQEAERQNQALQAAYEAKLAEIKQIESENAAIRKRN---EQAGQTTNQTNQAAQAAYQE 400
+ + L A+ EAK KQ+E+E+ + ++N E + Q+ + A++ A ++
Sbjct: 307 LNANRQSLRRDLDASREAK----KQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQ 362

Query: 401 KLAEIERINAENAAIR------DRNTKARQEAERQNQQLKTTYEAQLSAYQQA------- 447
AE +++ +N R+ A +EA++Q ++ ++L+A ++
Sbjct: 363 LEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQVEKALEEANSKLAALEKLNKELEES 422

Query: 448 ----------LQAKKEAENKAIDQ 461
LQAK EAE KA+ +
Sbjct: 423 KKLTEKEKAELQAKLEAEAKALKE 446



Score = 58.9 bits (142), Expect = 9e-11
Identities = 61/346 (17%), Positives = 112/346 (32%), Gaps = 32/346 (9%)

Query: 117 LEKQTQAVTEATTKQEANTTAINQAVSENKAIDQANRDEKARVDALNTKGEADTKAKNET 176
L+ T +V A T A VS Q + EK + + + + K +
Sbjct: 15 LKTGTASVAVALTVLGAGLVVNTNEVSAVATRSQTDTLEKVQ-ERADKFEIENNTLKLKN 73

Query: 177 GQAQVDAQNKQAQ-AAADAMNAKLKADYEAKLTEIKQIESENEAIRQRNQQASQATHQAN 235
+ + + + K + + S+ + + R +A
Sbjct: 74 SDLSFNNKALKDHNDELTEELSNAKEKLRKNDKSLSEKASKIQELEARKADLEKA----L 129

Query: 236 QAAQAAYQEKLAEIERIKAENAAIRDRNAKAQQEAERQNQALQAAYEAKLAEIKQIESEN 295
+ A A+I+ ++AE AA+ R A ++ E
Sbjct: 130 EGAMNFSTADSAKIKTLEAEKAALAARKADLEKALE--------GAMNFSTADSAKIKTL 181

Query: 296 AAIRQRNEQAGQATNQTNQAAQAAYQEKLAEIERIKAGNAAIRDRNAKAQQ---EAERQN 352
A + E + + A A+I+ ++A AA+ R A ++ A +
Sbjct: 182 EAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFS 241

Query: 353 QALQAAYEAKLAEIKQIESENAAIRKRNEQAGQTTNQTNQAAQAAYQEKLAEIERINAEN 412
A A + AE +E+ A + K E A + A A + AE + AE
Sbjct: 242 TADSAKIKTLEAEKAALEARQAELEKALEGA----MNFSTADSAKIKTLEAEKAALEAEK 297

Query: 413 AAIRDRNTKARQEAERQNQQLKTTYEAQLSAYQQALQAKKEAENKA 458
A E Q+Q L ++ + +AKK+ E +
Sbjct: 298 AD-----------LEHQSQVLNANRQSLRRDLDASREAKKQLEAEH 332



Score = 31.6 bits (71), Expect = 0.022
Identities = 46/249 (18%), Positives = 88/249 (35%), Gaps = 29/249 (11%)

Query: 100 KQSEKVTHDSLSSAQADLEKQTQAVTEATTKQEANTTAINQAVSENKAIDQANRDEKARV 159
++ + + + A + ++A A + + ANR R
Sbjct: 258 LEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRRD 317

Query: 160 DALNTKGEADTKAKNETGQAQVDAQNK-------------QAQAAADAMNAKLKADYEAK 206
+ + + +A+++ + Q +A+ +A + KL+ +
Sbjct: 318 LDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQLEAEHQKLEEQNKIS 377

Query: 207 LTEIKQIESENEAIRQRNQQASQATHQANQAAQA------AYQEKLAEIERIKAENAAIR 260
+ + + +A R+ +Q +A +AN A +E E+ KAE A
Sbjct: 378 EASRQSLRRDLDASREAKKQVEKALEEANSKLAALEKLNKELEESKKLTEKEKAELQAKL 437

Query: 261 DRNAKAQQEAERQNQALQAAYEAKLAEIKQIESENAAIRQRNE------QAGQATNQTNQ 314
+ AKA +E A QA AKL K +S+ + N+ QA QA + NQ
Sbjct: 438 EAEAKALKEKL----AKQAEELAKLRAGKASDSQTPDAKPGNKAVPGKGQAPQAGTKPNQ 493

Query: 315 AAQAAYQEK 323
+ K
Sbjct: 494 NKAPMKETK 502


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1400IGASERPTASE451e-06 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 45.1 bits (106), Expect = 1e-06
Identities = 42/236 (17%), Positives = 84/236 (35%), Gaps = 17/236 (7%)

Query: 383 RANIGWYPIANLWNEQSRDAIDTA--------EVGVPFFKITTQKMAQLEMAKAVANEGL 434
R G Y + N E+ +DT + VP +++A+++ A
Sbjct: 972 RNVNGRYDLYNPEVEKRNQTVDTTNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPA 1031

Query: 435 DEAKQAVKQAEANVTALEQVISQTSQAKEQLAAAKANLVTAKDMLDKAKQTAKLTEQDLE 494
++ AE + + V A E A + AK + QT ++ + E
Sbjct: 1032 TPSETTETVAENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSE 1091

Query: 495 TKTANLKQAQEHLTLKQDDLAKAQTELAAQEKSLEQLTQVLSLAQENLGRATKAVEQTKA 554
TK + +E T+++++ AK +TE + + +Q + + Q +A
Sbjct: 1092 TKETQTTETKETATVEKEEKAKVETEKTQEVPKVT--------SQVSPKQEQSETVQPQA 1143

Query: 555 DLTQKQAYVTNLKQVTKLRQESQAKVNQAKAVLSEASARLEQELETLKTLQAKEAN 610
+ ++ N+K+ + A Q S + E T+ T + N
Sbjct: 1144 EPARENDPTVNIKEPQSQ-TNTTADTEQPAKETSSNVEQPVTESTTVNTGNSVVEN 1198



Score = 43.5 bits (102), Expect = 3e-06
Identities = 42/248 (16%), Positives = 82/248 (33%), Gaps = 12/248 (4%)

Query: 13 AALSTGTGLVQADDLSNTRPAKAAEVVTHTEVTENQVADAKTKADEATKAVKDQEATVKA 72
+ S + + D+ PA A T V EN ++KT A A
Sbjct: 1009 SVPSNNEEIARVDEAPVPPPAPATPSETTETVAENSKQESKTVEKNEQDA-----TETTA 1063

Query: 73 IEAEKSQAQQSLVEATTAVNDTEKLASEA-------TPDGLTKAQEETEASQSAVTDAQA 125
E ++ +S V+A T N+ + SE T + T +EE ++ T
Sbjct: 1064 QNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETKETATVEKEEKAKVETEKTQEVP 1123

Query: 126 QLEAAQEAESKAQTAVDHQKETVAKASQAVNQAKAALTTSNQAADVSAAEEKVLEAQEAV 185
++ + + + V Q E + VN + T+ A A+E ++ V
Sbjct: 1124 KVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQTNTTADTEQPAKETSSNVEQPV 1183

Query: 186 TKAETQVSQAQEADAKHESDVRHAKEELDLKSQKLTEKQTTLEQVMAAIEAERLTKPVEN 245
T++ T + + + + ++ +S + + E T +
Sbjct: 1184 TESTTVNTGNSVVENPENTTPATTQPTVNSESSNKPKNRHRRSVRSVPHNVEPATTSSND 1243

Query: 246 GTYFNQRD 253
+ D
Sbjct: 1244 RSTVALCD 1251



Score = 31.6 bits (71), Expect = 0.013
Identities = 29/133 (21%), Positives = 45/133 (33%), Gaps = 6/133 (4%)

Query: 112 ETEASQSAVTDAQAQLEAAQEAESKAQTAVDHQKETVAKASQAVNQAKAALT---TSNQA 168
E E V +A+ +V E +A+ +A A T T+
Sbjct: 984 EVEKRNQTVDTTNITTPNNIQAD---VPSVPSNNEEIARVDEAPVPPPAPATPSETTETV 1040

Query: 169 ADVSAAEEKVLEAQEAVTKAETQVSQAQEADAKHESDVRHAKEELDLKSQKLTEKQTTLE 228
A+ S E K +E E T ++ +AK E+ + E QTT
Sbjct: 1041 AENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTET 1100

Query: 229 QVMAAIEAERLTK 241
+ A +E E K
Sbjct: 1101 KETATVEKEEKAK 1113



Score = 30.0 bits (67), Expect = 0.041
Identities = 27/148 (18%), Positives = 45/148 (30%), Gaps = 13/148 (8%)

Query: 29 NTRPAKAAEVVTHTEVTENQVADAKTKADEATKAVKDQEAT---VKAIEAEKSQAQQSLV 85
+ + + T T N V + AT + K ++ V
Sbjct: 1175 TSSNVEQPVTESTTVNTGNSVVENPENTTPATTQPTVNSESSNKPKNRHRRSVRSVPHNV 1234

Query: 86 E-ATTAVNDTEKLAS---------EATPDGLTKAQEETEASQSAVTDAQAQLEAAQEAES 135
E ATT+ ND +A D KAQ AV+ +QLE E +
Sbjct: 1235 EPATTSSNDRSTVALCDLTSTNTNAVLSDARAKAQFVALNVGKAVSQHISQLEMNNEGQY 1294

Query: 136 KAQTAVDHQKETVAKASQAVNQAKAALT 163
+ + + + +K+ T
Sbjct: 1295 NVWVSNTSMNKNYSSSQYRRFSSKSTQT 1322


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1406ADHESNFAMILY290.003 Adhesin family signature.
		>ADHESNFAMILY#Adhesin family signature.

Length = 309

Score = 29.4 bits (66), Expect = 0.003
Identities = 20/61 (32%), Positives = 25/61 (40%), Gaps = 14/61 (22%)

Query: 3 KKLVGFIVLALSTIILVACSNDSLEGE----------YYWINDARNQHMATIKGDKGYVE 52
KKL +VL LS IILVAC++ + I D I GDK +
Sbjct: 2 KKLGTLLVLFLSAIILVACASGKKDTTSGQKLKVVATNSIIADITKN----IAGDKIDLH 57

Query: 53 S 53
S
Sbjct: 58 S 58


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1410GPOSANCHOR611e-11 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 61.2 bits (148), Expect = 1e-11
Identities = 23/69 (33%), Positives = 35/69 (50%), Gaps = 11/69 (15%)

Query: 887 DPRTDADKNDPAGKNQQVKGKGN-----------KLPATGENATPFFNVAALTIISSVGL 935
D + G+ Q K N +LP+TGE A PFF AALT++++ G+
Sbjct: 470 DAKPGNKAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETANPFFTAAALTVMATAGV 529

Query: 936 LSVSKKKED 944
+V K+KE+
Sbjct: 530 AAVVKRKEE 538



Score = 46.2 bits (109), Expect = 5e-07
Identities = 14/55 (25%), Positives = 21/55 (38%)

Query: 14 QTKQRFSIKKFKFGAASVLIGLSFLGGVTQGNLNIFEESIVAASTIPGSAATLNT 68
T + +S++K K G ASV + L+ LG N N + T
Sbjct: 5 NTNRHYSLRKLKTGTASVAVALTVLGAGLVVNTNEVSAVATRSQTDTLEKVQERA 59


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1420HTHFIS842e-19 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 84.5 bits (209), Expect = 2e-19
Identities = 31/133 (23%), Positives = 50/133 (37%), Gaps = 6/133 (4%)

Query: 4 KVLLVDDEYMILQGLTMIIDWQALGFEVVQTARSGKEALTYLTQYPVDVMISDVTMPGMT 63
+L+ DD+ I L + G++V + ++ D++++DV MP
Sbjct: 5 TILVADDDAAIRTVLNQAL--SRAGYDVR-ITSNAATLWRWIAAGDGDLVVTDVVMPDEN 61

Query: 64 GLDLIEAAKTYHPQLQTLILSGYQEFSYVQKAMELETKGYLLKPVDKAELQAKMKQFKDC 123
DL+ K P L L++S F KA E YL KP D L +
Sbjct: 62 AFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFD---LTELIGIIGRA 118

Query: 124 LDAQQAESIRQEA 136
L + + E
Sbjct: 119 LAEPKRRPSKLED 131


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1421PF06580260.019 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 25.6 bits (56), Expect = 0.019
Identities = 13/69 (18%), Positives = 24/69 (34%), Gaps = 14/69 (20%)

Query: 1 MIQVLDNGRGISQERLADMEKRLQEHQTTGNSSIGLQNVYLRLFHHFRDRVSWSMAKEPN 60
++V + G L T ++ GLQNV RL + ++++
Sbjct: 293 TLEVENTGS-------------LALKNTKESTGTGLQNVRERLQMLYGTEAQIKLSEKQ- 338

Query: 61 GGFIIQIRI 69
G + I
Sbjct: 339 GKVNAMVLI 347


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1422PF065801511e-43 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 151 bits (383), Expect = 1e-43
Identities = 57/236 (24%), Positives = 104/236 (44%), Gaps = 20/236 (8%)

Query: 251 LSKAYRMQYNRSGDLLAYVAVRKSYLLAEAVRTVFVYGLVSLLLAWLLLQLL-FRVFRNY 309
L+ AYR R G L + + A + + V+ W LL + +
Sbjct: 55 LTHAYRSFIKRQG-WLKLNMGQIILRVLPACVVIGMVWFVANTSIWRLLAFINTKPVAFT 113

Query: 310 IQQVSEITDTVEMVAAGDLSLTIDNSHMELELYHISEAINQMLASIKAYIDEVYVLEVEQ 369
+ I V +V + M LY + +A ID+ +
Sbjct: 114 LPLALSIIFNVVVV-----------TFMWSLLYF---GWHFFKNYKQAEIDQWK-MASMA 158

Query: 370 RDAQMRALQSQINPHFLYNTLEYIRMYALSCQQEELADVIYAFASLLRNNI--SQDKMTT 427
++AQ+ AL++QINPHF++N L IR L + +++ + + L+R ++ S + +
Sbjct: 159 QEAQLMALKAQINPHFMFNALNNIRALILE-DPTKAREMLTSLSELMRYSLRYSNARQVS 217

Query: 428 LKEELAFCEKYIYLYQMRYPDSFAYHVKIDESIADLAIPKFVIQPLVENYFVHGID 483
L +EL + Y+ L +++ D + +I+ +I D+ +P ++Q LVEN HGI
Sbjct: 218 LADELTVVDSYLQLASIQFEDRLQFENQINPAIMDVQVPPMLVQTLVENGIKHGIA 273


19MGAS10270_Spy1537MGAS10270_Spy1551Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy1537217-2.353346Protein ecsB
MGAS10270_Spy1538217-1.084911ABC-type transporter ATP-binding protein ecsA
MGAS10270_Spy1539-114-0.760077Bis(5'-nucleosyl)-tetraphosphatase
MGAS10270_Spy1540-212-0.783089hypothetical protein
MGAS10270_Spy1541-417-0.164635Transcriptional regulator, LytR family
MGAS10270_Spy1542-3221.047822Acetyltransferase
MGAS10270_Spy1543-1271.986538ATP/GTP hydrolase
MGAS10270_Spy15440281.869985Guanine-hypoxanthine permease
MGAS10270_Spy15450382.987271Hydrolase
MGAS10270_Spy1546-1363.331102PTS system, mannose-specific IIAB component
MGAS10270_Spy1547-1283.416874PTS system, mannose-specific IIC component
MGAS10270_Spy1548-1202.863822PTS system, mannose-specific IID component
MGAS10270_Spy15490152.658296hypothetical cytosolic protein
MGAS10270_Spy1550-1163.171036Seryl-tRNA synthetase
MGAS10270_Spy15511163.001009Acetyl-coenzyme A carboxylase carboxyl
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1542SACTRNSFRASE621e-14 Streptothricin acetyltransferase signature.
		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

Length = 173

Score = 61.9 bits (150), Expect = 1e-14
Identities = 27/86 (31%), Positives = 40/86 (46%), Gaps = 4/86 (4%)

Query: 62 CLLARLDEKVVGLLNLSGEVLSQGQAEADVFMLVAKTYRGYGIGQLLLEIALDWAEENPY 121
L L+ +G + + E + VAK YR G+G LL A++WA+EN +
Sbjct: 67 AFLYYLENNCIGRIKIRSNWNGYALIED---IAVAKDYRKKGVGTALLHKAIEWAKENHF 123

Query: 122 IESLKLDVQVRNTKAIYLYKKYGFRI 147
L L+ Q N A + Y K+ F I
Sbjct: 124 C-GLMLETQDINISACHFYAKHHFII 148


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1544TYPE3IMSPROT320.005 Type III secretion system inner membrane S protein ...
		>TYPE3IMSPROT#Type III secretion system inner membrane S protein

family signature.
Length = 354

Score = 32.0 bits (73), Expect = 0.005
Identities = 19/123 (15%), Positives = 43/123 (34%), Gaps = 8/123 (6%)

Query: 372 LTAVSTAVCFLLSILLLPLVGIVPAAATAPALIVVGVMMVSSFLDVNWSKF--ADALPAF 429
L+ V V L PL+ + A A ++ G ++ + + K +
Sbjct: 72 LSYVVDNVLLEFFYLCFPLLTVAALMAIASHVVQYGFLISGEAIKPDIKKINPIEGAKRI 131

Query: 430 FAA-FFMALCYSISYGIAAAFIFYCLVK-----VVEGKTKDIHPIIWGATFLFIVNFIIL 483
F+ + SI + + + + ++K +++ T I I + +I
Sbjct: 132 FSIKSLVEFLKSILKVVLLSILIWIIIKGNLVTLLQLPTCGIECITPLLGQILRQLMVIC 191

Query: 484 TIL 486
T+
Sbjct: 192 TVG 194


20MGAS10270_Spy1618MGAS10270_Spy1626Y        NNGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy16182260.642527Magnesium and cobalt transport protein corA
MGAS10270_Spy16190220.285688hypothetical membrane spanning protein
MGAS10270_Spy1620122-1.116940SSU ribosomal protein S18P
MGAS10270_Spy1621018-1.723690Single strand binding protein
MGAS10270_Spy1622016-3.337625SSU ribosomal protein S6P
MGAS10270_Spy1623-115-3.068387hypothetical protein
MGAS10270_Spy1624-115-3.022856A/G-specific adenine DNA glycosylase
MGAS10270_Spy1625-114-3.715381Transcriptional regulator
MGAS10270_Spy1626-214-3.223276Thioredoxin
21MGAS10270_Spy1645MGAS10270_Spy1653Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy1645215-0.764904Transcriptional regulator, Cro/CI family
MGAS10270_Spy1646114-1.408143Transcriptional regulator
MGAS10270_Spy1647114-2.335301hypothetical cytosolic protein
MGAS10270_Spy1648017-5.547237Transcriptional regulator, MerR family
MGAS10270_Spy1649018-6.432317DNA polymerase III, epsilon chain
MGAS10270_Spy1650016-4.987580hypothetical cytosolic protein
MGAS10270_Spy1651017-5.093715hypothetical protein
MGAS10270_Spy1652-114-4.488859ABC transporter ATP-binding protein
MGAS10270_Spy1653-114-3.245791hypothetical ABC transporter permease protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1647TYPE4SSCAGX270.014 Type IV secretion system CagX conjugation protein si...
		>TYPE4SSCAGX#Type IV secretion system CagX conjugation protein

signature.
Length = 522

Score = 27.1 bits (59), Expect = 0.014
Identities = 25/85 (29%), Positives = 43/85 (50%), Gaps = 7/85 (8%)

Query: 9 KQAQKLQKQMEQKQADLAAMQFTGKSAQDLVTA-----TFTGDKKLVGIDFKEAVVDPED 63
+QAQK QK +K+ + A + ++L A + +K L + ++ + +
Sbjct: 156 EQAQKAQKDKREKRKEERAKNRA--NLENLTNAMSNPQNLSNNKNLSELIKQQRENELDQ 213

Query: 64 VETLQDMTTQAINDALTQIDEATKK 88
+E L+DM QA +AL QI+E KK
Sbjct: 214 MERLEDMQEQAQANALKQIEELNKK 238


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1648BCTERIALGSPF280.030 Bacterial general secretion pathway protein F signa...
		>BCTERIALGSPF#Bacterial general secretion pathway protein F

signature.
Length = 408

Score = 28.3 bits (63), Expect = 0.030
Identities = 14/57 (24%), Positives = 27/57 (47%), Gaps = 1/57 (1%)

Query: 133 KNQKAWKKLQWKMGISIFLAIVSY-VGLILLSSYLQKFWLVYVAMGLFLPGFSWLVI 188
+ Q+ ++Q M L +V+ V ILLS + K ++ M LP + +++
Sbjct: 161 QRQQMRSRIQQAMIYPCVLTVVAIAVVSILLSVVVPKVVEQFIHMKQALPLSTRVLM 217


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1650IGASERPTASE320.001 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 32.3 bits (73), Expect = 0.001
Identities = 24/102 (23%), Positives = 46/102 (45%), Gaps = 10/102 (9%)

Query: 84 EETKQRELLEILVDEKNTEITRLYEQLKAKDAQLASKDEQMRVKDVQIAEKDKQLDQQQQ 143
E ++E + +E++ T + AK+A+ K + Q E + +
Sbjct: 1041 AENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVKA------NTQTNEVAQS--GSET 1092

Query: 144 LTAKAMADKETLKLELEE-AKAEADQARLQVEEVQAEVGPKK 184
+ KET +E EE AK E ++ + +V +V ++V PK+
Sbjct: 1093 KETQTTETKETATVEKEEKAKVETEKTQ-EVPKVTSQVSPKQ 1133


22MGAS10270_Spy1690MGAS10270_Spy1712Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy1690418-6.010990Type I restriction-modification system
MGAS10270_Spy1691318-7.067280Type I restriction-modification system
MGAS10270_Spy1693424-8.649954hypothetical protein
MGAS10270_Spy1692525-8.460077hypothetical protein
MGAS10270_Spy1694523-8.131812Transcriptional regulatory protein degU
MGAS10270_Spy1695423-8.027611Sensory transduction protein kinase
MGAS10270_Spy1696316-6.150553ABC transporter permease protein
MGAS10270_Spy1697016-3.721982ABC transporter ATP-binding protein
MGAS10270_Spy1698016-3.245791Lantibiotic transport ATP-binding protein
MGAS10270_Spy1699118-2.669885serine/threoninedehydratase
MGAS10270_Spy1700123-1.348571Lantibiotic salivaricin A
MGAS10270_Spy1701124-1.3041746-phospho-beta-galactosidase
MGAS10270_Spy1702126-1.257513PTS system, lactose-specific IIBC component
MGAS10270_Spy1703223-2.387058PTS system, lactose-specific IIA component
MGAS10270_Spy1704222-2.617307Tagatose-bisphosphate aldolase
MGAS10270_Spy1705120-3.488033Tagatose-6-phosphate kinase
MGAS10270_Spy1706020-3.093094Galactose-6-phosphate isomerase lacB subunit
MGAS10270_Spy1707219-3.213265Galactose-6-phosphate isomerase lacA subunit
MGAS10270_Spy1708320-3.187719Lactose phosphotransferase system repressor
MGAS10270_Spy1709231-0.207714DNA-damage-inducible protein J
MGAS10270_Spy17103381.612586hypothetical cytosolic protein
MGAS10270_Spy17115393.258274DNA integration/recombination/inversion protein
MGAS10270_Spy17131293.003816hypothetical protein
MGAS10270_Spy1712-1213.538226DNA integration/recombination/inversion protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1694HTHFIS463e-08 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 46.0 bits (109), Expect = 3e-08
Identities = 21/118 (17%), Positives = 51/118 (43%), Gaps = 6/118 (5%)

Query: 2 KILLIDDHRLFAKSIQLLFQQYD-EVDVIDTITSHFNDVTIDLSKYDIILLDINLTNISK 60
IL+ DD + + +V + + + + D+++ D+ +
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWI--AAGDGDLVVTDVVM---PD 59

Query: 61 ENGLEIAKELIQSTPHLKVVMLTGYVKSIYRERAKKVGAYGFVDKNIDPKQLISILKK 118
EN ++ + ++ P L V++++ + +A + GAY ++ K D +LI I+ +
Sbjct: 60 ENAFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGR 117


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1708ARGREPRESSOR300.006 Bacterial arginine repressor signature.
		>ARGREPRESSOR#Bacterial arginine repressor signature.

Length = 149

Score = 29.8 bits (67), Expect = 0.006
Identities = 21/85 (24%), Positives = 38/85 (44%), Gaps = 11/85 (12%)

Query: 1 MKKKERHEKILDILKVDGFIKVKDIIDEM-----NISDMTARRDLDTLADKGLL-IRTHG 54
M K +RH KI +I+ + +++D + N++ T RD+ L L+ + T+
Sbjct: 1 MNKGQRHIKIREIITANEIETQDELVDILKKDGYNVTQATVSRDIKEL---HLVKVPTNN 57

Query: 55 GAQYLDYSSAKDEGHEKTHTEKKVL 79
G+ YS D+ K+ L
Sbjct: 58 GSYK--YSLPADQRFNPLSKLKRSL 80


23MGAS10270_Spy1723MGAS10270_Spy1764Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy1723-1153.496657Cysteinyl-tRNA synthetase
MGAS10270_Spy1724-1163.620705hypothetical protein
MGAS10270_Spy1725-1184.538983hypothetical cytosolic protein
MGAS10270_Spy1726-1184.278115serineacetyltransferase
MGAS10270_Spy1727-1173.346070hypothetical protein
MGAS10270_Spy1728-1173.355467Polyribonucleotide nucleotidyltransferase
MGAS10270_Spy1729-1172.321204Transaldolase
MGAS10270_Spy1730-1192.384119Putative transport protein sgaT
MGAS10270_Spy1731-2210.985328PTS system, IIB component
MGAS10270_Spy1732-1191.333878Transcription antiterminator, BglG family / PTS
MGAS10270_Spy17330211.573659hypothetical protein
MGAS10270_Spy17340181.848267SSU ribosomal protein S15P
MGAS10270_Spy1735-1183.674858hypothetical protein
MGAS10270_Spy1736-2173.918152Putative transcriptional regulator
MGAS10270_Spy1737-2153.724987Peptide deformylase
MGAS10270_Spy1738-1153.565696Oxidoreductase
MGAS10270_Spy17390163.407819Transcriptional regulator, MarR family
MGAS10270_Spy17400163.422694DNA polymerase III alpha subunit
MGAS10270_Spy1741-2152.590913Prolyl-tRNA synthetase
MGAS10270_Spy17420143.064052Membrane endopeptidase, M50 family
MGAS10270_Spy1743-1123.704216Phosphatidate cytidylyltransferase
MGAS10270_Spy1744-1134.038142Undecaprenyl pyrophosphate synthetase
MGAS10270_Spy1745-1134.370424Protein translocase subunit YajC
MGAS10270_Spy1746-2134.539284Thioredoxin
MGAS10270_Spy1747-2144.641648Collagen-like surface protein
MGAS10270_Spy1749-2163.805270Pullulanase
MGAS10270_Spy1748-2193.709430hypothetical protein
MGAS10270_Spy1750-1214.275025Glucan 1,6-alpha-glucosidase
MGAS10270_Spy1751-2195.153041Multiple sugar transport ATP-binding protein
MGAS10270_Spy1752-2225.479233Leucine rich protein
MGAS10270_Spy1753-3215.210083Streptokinase
MGAS10270_Spy1754-2205.861863D-tyrosyl-tRNA(Tyr) deacylase
MGAS10270_Spy1755-1205.912222GTP pyrophosphokinase /
MGAS10270_Spy17560206.124082Collagen-like surface protein
MGAS10270_Spy17570194.927346NrdI protein
MGAS10270_Spy1758-1174.182622Endonuclease/Exonuclease/phosphatase family
MGAS10270_Spy1759-1163.976041PTS system, glucose-specific IIABC component
MGAS10270_Spy17600203.788186hypothetical cytosolic protein
MGAS10270_Spy1761-2233.933799Ribosomal protein L11 methyltransferase
MGAS10270_Spy1762-1233.648240hypothetical protein
MGAS10270_Spy1763-1233.385200RhuM
MGAS10270_Spy1764-2233.373460hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1742PF04605300.008 Virulence-associated protein D (VapD)
		>PF04605#Virulence-associated protein D (VapD)

Length = 125

Score = 29.8 bits (67), Expect = 0.008
Identities = 8/44 (18%), Positives = 17/44 (38%), Gaps = 2/44 (4%)

Query: 227 INGYKVTSWNDLTEAV-DLATRD-LGPSQTIKVTYKSHQRLKTV 268
+ ++ L E + DL +D + +Q+LK +
Sbjct: 80 FDITEIGEQYSLKETIQDLCAKDFHQKLKEFTEKTPKNQKLKDL 123


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1747GPOSANCHOR651e-13 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 64.7 bits (157), Expect = 1e-13
Identities = 37/87 (42%), Positives = 44/87 (50%), Gaps = 1/87 (1%)

Query: 224 ETPEQPGEKAPEKSKEVTPAPEKPADKEANQTPE-RRNGNMAKTPVANNHRRLPATGEQA 282
E + S+ P A Q P+ N K P+ R+LP+TGE A
Sbjct: 453 EELAKLRAGKASDSQTPDAKPGNKAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETA 512

Query: 283 NPFFTAAAVAVMTTAGVLAVTKRKENN 309
NPFFTAAA+ VM TAGV AV KRKE N
Sbjct: 513 NPFFTAAALTVMATAGVAAVVKRKEEN 539


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1751PF05272356e-04 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 34.7 bits (79), Expect = 6e-04
Identities = 14/56 (25%), Positives = 20/56 (35%), Gaps = 9/56 (16%)

Query: 34 IVFVGPSGCGKSTTLRMIAGLEDISEGELKIGGEVVNDKSPKDRDIAMVFQNYALY 89
+V G G GKST + + GL+ S+ IG +D Y
Sbjct: 599 VVLEGTGGIGKSTLINTLVGLDFFSDTHFDIG---------TGKDSYEQIAGIVAY 645


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1752HTHFIS347e-04 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 34.0 bits (78), Expect = 7e-04
Identities = 10/30 (33%), Positives = 19/30 (63%)

Query: 243 ALWSEHGNLVQTAQRLYIHRNSLQYKLDKF 272
AL + GN ++ A L ++RN+L+ K+ +
Sbjct: 444 ALTATRGNQIKAADLLGLNRNTLRKKIREL 473


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1753STREPKINASE7670.0 Streptococcus streptokinase protein signature.
		>STREPKINASE#Streptococcus streptokinase protein signature.

Length = 440

Score = 767 bits (1982), Expect = 0.0
Identities = 374/440 (85%), Positives = 391/440 (88%), Gaps = 8/440 (1%)

Query: 1 MKNYLSFGMFALLFALTFGTVKPVQAIAGPEWLLDRPSVNNSQLVVSVAGTVEGTNQEIS 60
MKNYLSFGMFALLFALTFGTV VQAIAGPEWLLDRPSVNNSQLVVSVAGTVEGTNQ+IS
Sbjct: 1 MKNYLSFGMFALLFALTFGTVNSVQAIAGPEWLLDRPSVNNSQLVVSVAGTVEGTNQDIS 60

Query: 61 LKFFEIDLTSRPAQGGKTEPGLRPKSK--------MPYKLEKADLLKAIQEQLIANVHSN 112
LKFFEIDLTSRPA GGKTE GL PKSK M +KLEKADLLKAIQEQLIANVHSN
Sbjct: 61 LKFFEIDLTSRPAHGGKTEQGLSPKSKPFATDSGAMSHKLEKADLLKAIQEQLIANVHSN 120

Query: 113 DGYFEVIDFASDATITDRNGKVYFADRDDSVTLPTQPVQEFLLSGHVRVRPYRPKAVHNS 172
D YFEVIDFASDATITDRNGKVYFAD+D SVTLPTQPVQEFLLSGHVRVRPY+ K + N
Sbjct: 121 DDYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLSGHVRVRPYKEKPIQNQ 180

Query: 173 AERVNVNYEVSFVSETGDLDFTPSLRDRYHLTTLAVGDSLSSQELAAIAQFILSKEHPDY 232
A+ V+V Y V F D DF P L+D L TLA+GD+++SQEL A AQ IL+K HP Y
Sbjct: 181 AKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKNHPGY 240

Query: 233 IITKRDSSIVTHDNDIFRTILPMDQEFTYHVKDREQAYGINKKSGQKEKINNTDLISEKY 292
I +RDSSIVTHDNDIFRTILPMDQEFTY VK+REQAY INKKSG E+INNTDLISEKY
Sbjct: 241 TIYERDSSIVTHDNDIFRTILPMDQEFTYRVKNREQAYRINKKSGLNEEINNTDLISEKY 300

Query: 293 YVLKKGEKPYDPFDRSHLKLFTINYVDVDTNKLLKSEQLLTASERNLDFRDLYDPRDKAK 352
YVLKKGEKPYDPFDRSHLKLFTI YVDVDTN+LLKSEQLLTASERNLDFRDLYDPRDKAK
Sbjct: 301 YVLKKGEKPYDPFDRSHLKLFTIKYVDVDTNELLKSEQLLTASERNLDFRDLYDPRDKAK 360

Query: 353 LLYNNLDAFGIMDYTLTGKVEDNHDDTNRIITVYMGKRPEGENASYHLAYDKDRYTEEER 412
LLYNNLDAFGIMDYTLTGKVEDNHDDTNRIITVYMGKRPEGENASYHLAYDKDRYTEEER
Sbjct: 361 LLYNNLDAFGIMDYTLTGKVEDNHDDTNRIITVYMGKRPEGENASYHLAYDKDRYTEEER 420

Query: 413 EVYSYLRYTGTPIPDNPKDK 432
EVYSYLRYTGTPIPDNP DK
Sbjct: 421 EVYSYLRYTGTPIPDNPNDK 440


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1756GPOSANCHOR644e-13 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 63.5 bits (154), Expect = 4e-13
Identities = 43/130 (33%), Positives = 56/130 (43%), Gaps = 3/130 (2%)

Query: 254 EAGKPGEKAPEKSPEVTPTPETPEQP---GEKAPEKSPEVTPTPEMPEQPGEKAPEKSKE 310
A + K E+S ++T + Q E K E+ + KA +
Sbjct: 410 AALEKLNKELEESKKLTEKEKAELQAKLEAEAKALKEKLAKQAEELAKLRAGKASDSQTP 469

Query: 311 VTPAPEKPADKEANQTPERRNGNMAKTPVANNHRRLPATGEQANPFFTAAAVAVMTTAGV 370
K + N K P+ R+LP+TGE ANPFFTAAA+ VM TAGV
Sbjct: 470 DAKPGNKAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETANPFFTAAALTVMATAGV 529

Query: 371 LAVTKRKENN 380
AV KRKE N
Sbjct: 530 AAVVKRKEEN 539


24MGAS10270_Spy1778MGAS10270_Spy1785Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy17782122.115744hypothetical protein
MGAS10270_Spy17793131.958853Streptococcal histidine triad protein
MGAS10270_Spy17807171.887192Laminin-binding surface protein
MGAS10270_Spy17816181.226258Fibronectin-binding protein
MGAS10270_Spy17826180.512706C5A peptidase precursor
MGAS10270_Spy17831020-0.964100M protein
MGAS10270_Spy17845210.829185M protein
MGAS10270_Spy17852210.699980M protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1779PF05616340.003 Neisseria meningitidis TspB protein
		>PF05616#Neisseria meningitidis TspB protein

Length = 501

Score = 34.0 bits (77), Expect = 0.003
Identities = 24/87 (27%), Positives = 35/87 (40%), Gaps = 2/87 (2%)

Query: 226 IPKKDLSPSELAAAQAYWSQKQGRGARPSDY-RPTPAPGRRKAPIPDVTPNPGRGHQPD- 283
IP+ DL+P A A + P++ P PG R P PD NP D
Sbjct: 310 IPRPDLTPGSAEAPNAQPLPEVSPAENPANNPAPNENPGTRPNPEPDPDLNPDANPDTDG 369

Query: 284 NGGYHPAPPRPNDASQNKHQRDEFKGK 310
G P P D +H+++ +G+
Sbjct: 370 QPGTRPDSPAVPDRPNGRHRKERKEGE 396


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1780ADHESNFAMILY2475e-83 Adhesin family signature.
		>ADHESNFAMILY#Adhesin family signature.

Length = 309

Score = 247 bits (631), Expect = 5e-83
Identities = 82/323 (25%), Positives = 143/323 (44%), Gaps = 34/323 (10%)

Query: 1 MKKGFFLMAMVVSLVMIAGCDKSANPKQPTQGMSVVTSFYPMYAMTKEVSGDLNDVR-MI 59
MKK L+ + +S +++ C Q + VV + + +TK ++GD D+ ++
Sbjct: 1 MKKLGTLLVLFLSAIILVACASGKKDTTSGQKLKVVATNSIIADITKNIAGDKIDLHSIV 60

Query: 60 QSGAGIHSFEPSVNDVAAIYDADLFVYHSHTLE----AWARDLDPNLKKSKVDVFEASKP 115
G H +EP DV +ADL Y+ LE AW L N KK++ + A
Sbjct: 61 PIGQDPHEYEPLPEDVKKTSEADLIFYNGINLETGGNAWFTKLVENAKKTENKDYFA--- 117

Query: 116 LTLDRVKGLEDMEVTQGIDPATLY--------DPHTWTDPVLAGEEAVNIAKELGRLDPK 167
V+ G+D L DPH W + A NIAK+L DP
Sbjct: 118 -------------VSDGVDVIYLEGQNEKGKEDPHAWLNLENGIIFAKNIAKQLSAKDPN 164

Query: 168 HKDSYTKKAKAFKKEAEQLTEEYTQKFKKVR--SKTFVTQHTAFSYLAKRFGLKQLGISG 225
+K+ Y K K + + ++L +E KF K+ K VT AF Y +K +G+ I
Sbjct: 165 NKEFYEKNLKEYTDKLDKLDKESKDKFNKIPAEKKLIVTSEGAFKYFSKAYGVPSAYIWE 224

Query: 226 ISPEQEPSPRQLKEIQDFVKEYNVKTIFAEDNVNPKIAHAIAKSTGAKVKT---LSPLEA 282
I+ E+E +P Q+K + + +++ V ++F E +V+ + +++ T + +
Sbjct: 225 INTEEEGTPEQIKTLVEKLRQTKVPSLFVESSVDDRPMKTVSQDTNIPIYAQIFTDSIAE 284

Query: 283 APSGNKTYLENLRANLEVLYQQL 305
+Y ++ NL+ + + L
Sbjct: 285 QGKEGDSYYSMMKYNLDKIAEGL 307


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1781IGASERPTASE531e-09 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 53.1 bits (127), Expect = 1e-09
Identities = 52/331 (15%), Positives = 99/331 (29%), Gaps = 30/331 (9%)

Query: 2 QSISSTQGNTANTSQKWYDINEHGIIPVDISLETAKEDFKKEVEKSRLSKEQQKTYNQKI 61
Q++ +T T N Q +P S + +T
Sbjct: 990 QTVDTTNITTPNNIQA--------DVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVA 1041

Query: 62 EAAKNKDDLLLTYHREYSEDIKKHSASTEPTTQPVEAPVQETQASASDSMVTDDSTSVTT 121
E +K + + ++ +E ++ + V+A Q + + S S + T+ T
Sbjct: 1042 ENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETK 1101

Query: 122 DSPKESP----------VAPASSPESEKSSVAASSEETSSPETPAAPEAPALSEAPVQPA 171
++ S+ S SE PA P ++ Q
Sbjct: 1102 ETATVEKEEKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQ 1161

Query: 172 ESEEPSVAAPSEETPSPAAPE-----TPEEPAAPAPSPESEEPSVAASSEETPSPAAPAL 226
+ P++ET S T + +PE+ P+ + + S P
Sbjct: 1162 TNTTADTEQPAKETSSNVEQPVTESTTVNTGNSVVENPENTTPATTQPTVNSESSNKPKN 1221

Query: 227 SEAPAQPAESEKPSVAASSEETPSPSTPAESETQTPPAVTKDSDKPSSAAEKPAASSLVS 286
+ + A +S S + + AV S A K +L
Sbjct: 1222 RHRRSVRSVPHNVEPATTSSNDRSTVALCDLTSTNTNAVL------SDARAKAQFVALNV 1275

Query: 287 EQTVQQPTSKRSSDKKEEQEQSYSPNRSLSR 317
+ V Q S+ + E Q + N S+++
Sbjct: 1276 GKAVSQHISQLEMN-NEGQYNVWVSNTSMNK 1305



Score = 52.0 bits (124), Expect = 2e-09
Identities = 41/248 (16%), Positives = 73/248 (29%), Gaps = 24/248 (9%)

Query: 85 HSASTEPTTQPVEAPVQETQASASDSMVTDDSTSVTTDSPKESPVAPASSP--------- 135
++ E Q V+ T + + + S + E+PV P +
Sbjct: 981 YNPEVEKRNQTVDTTNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETV 1040

Query: 136 -ESEKSSVAASSEETSSPETPAAPEAPALSEA----PVQPAESEEPSVAAPSEETPSPAA 190
E+ K + A EA +E + ++ET +
Sbjct: 1041 AENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTET 1100

Query: 191 PETP----EEPAAPAPSPESEEPSVAASSEETPSPAAPALSEAPAQPAESEKPSVAASSE 246
ET EE A E P V S+ +P + A+PA P+V
Sbjct: 1101 KETATVEKEEKAKVETEKTQEVPKVT--SQVSPKQEQSETVQPQAEPARENDPTVNIKEP 1158

Query: 247 ETPSPSTPAESE--TQTPPAVTK--DSDKPSSAAEKPAASSLVSEQTVQQPTSKRSSDKK 302
++ + +T + +T V + + + + QPT S K
Sbjct: 1159 QSQTNTTADTEQPAKETSSNVEQPVTESTTVNTGNSVVENPENTTPATTQPTVNSESSNK 1218

Query: 303 EEQEQSYS 310
+ S
Sbjct: 1219 PKNRHRRS 1226



Score = 42.7 bits (100), Expect = 2e-06
Identities = 37/204 (18%), Positives = 68/204 (33%), Gaps = 17/204 (8%)

Query: 125 KESPVAPASSPESEKSSVAASSEETSSPETPAAPEAPALSEAPVQPAESEE------PSV 178
+ V + S +++ E EAP AP P+E+ E
Sbjct: 988 RNQTVDTTNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVAENSKQE 1047

Query: 179 AAPSEETPSPAAPETPE-----EPAAPAPSPESEEPSVAASSEETPSPAAPALSEAPAQP 233
+ E+ A T + + A ++ VA S ET E
Sbjct: 1048 SKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETKETATVE 1107

Query: 234 AESEKPSVAASSEETPS-----PSTPAESETQTPPAVTKDSDKPSSAAEKPAASSLVSEQ 288
E + ++E P +SET P A + P+ ++P + + +
Sbjct: 1108 KEEKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQT-NTTA 1166

Query: 289 TVQQPTSKRSSDKKEEQEQSYSPN 312
+QP + SS+ ++ +S + N
Sbjct: 1167 DTEQPAKETSSNVEQPVTESTTVN 1190


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1782SUBTILISIN1066e-27 Subtilisin serine protease family (S8) signature.
		>SUBTILISIN#Subtilisin serine protease family (S8) signature.

Length = 326

Score = 106 bits (266), Expect = 6e-27
Identities = 49/226 (21%), Positives = 84/226 (37%), Gaps = 47/226 (20%)

Query: 117 KAGKGAGTVVAVIDAGFDKNHEAWRLTDKAKARYQSKEDLEKAKKEHGITYGEWVNDKVA 176
+G G VAV+D G D +H DL KA+ G + +
Sbjct: 36 NQTRGRGVKVAVLDTGCDADH----------------PDL-KARIIGGRNFTDDDEGDPE 78

Query: 177 YYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLA 236
+ DY+ HGTHV+G ++ + G PEA LL+++V G
Sbjct: 79 IFKDYNG---------HGTHVAGTIAATENE-----NGVVGVAPEADLLIIKVLNKQGSG 124

Query: 237 DYARNYAQAIRDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGND 296
Y Q I A+ +I+MS G E +A A + + ++ +AGN+
Sbjct: 125 QYD-WIIQGIYYAIEQKVDIISMSLGGPE-----DVPELHEAVKKAVASQILVMCAAGNE 178

Query: 297 SSFGGKPRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETAT 342
+ +G P + ++V + + D+ +E +
Sbjct: 179 GDGDDR----------TDELGYPGCYNEVISVGAINFDRHASEFSN 214



Score = 79.9 bits (197), Expect = 5e-18
Identities = 37/139 (26%), Positives = 58/139 (41%), Gaps = 22/139 (15%)

Query: 457 NATPKVLPTASGTK---LSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSM 513
+V+ + S FS+ + D+ APG+DILS+V KYA SGTSM
Sbjct: 192 GCYNEVISVGAINFDRHASEFSNSNN------EVDLVAPGEDILSTVPGGKYATFSGTSM 245

Query: 514 SAPLVAGIMGL-LQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGA 572
+ P VAG + L Q + D+T E L+ L + SP+ +G
Sbjct: 246 ATPHVAGALALIKQLANASFERDLTEPE----LYAQLIKRTIPLGN-------SPKMEGN 294

Query: 573 GAVDAKKASA-ATMYVTDK 590
G + + ++ T +
Sbjct: 295 GLLYLTAVEELSRIFDTQR 313


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1783GPOSANCHOR1169e-31 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 116 bits (291), Expect = 9e-31
Identities = 157/384 (40%), Positives = 210/384 (54%), Gaps = 38/384 (9%)

Query: 5 QTKKNYSLRKLKTGTASVAVALTVLGAGFANQTEVRADEAKKMEVKESEKESQYKTLALR 64
K + A A L T A K + +
Sbjct: 175 SAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKAL 234

Query: 65 GENADLRNVNAKYLEKINAE----EEKNKKLEAINKELNENYYKLQDGIDALEKEKEDLK 120
+ ++ ++ + AE E + +LE + I LE EK L+
Sbjct: 235 EGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALE 294

Query: 121 TTLAKTTKENEISEASRKGLSRDLEASRTAKKELEAKHQKLEAENKKLTEGNQVSEASRK 180
A ++++ A+R+ L RDL+ASR AKK+LEA+HQKLE E N++SEASR+
Sbjct: 295 AEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLE-------EQNKISEASRQ 347

Query: 181 GLSNDLEASRAAKKELEAKYQKLETDHQALEAKHQKLEADYQVSETSRKGLSRDLEASRE 240
L DL+ASR AKK+LEA+ HQKLE ++SE SR+ L RDL+ASRE
Sbjct: 348 SLRRDLDASREAKKQLEAE--------------HQKLEEQNKISEASRQSLRRDLDASRE 393

Query: 241 ANKKVTSELTQAKAQLSALE-------ESKKLSEKEKAELQAKLDAQGKALKEQLAKQTE 293
A K+V L +A ++L+ALE ESKKL+EKEKAELQAKL+A+ KALKE+LAKQ E
Sbjct: 394 AKKQVEKALEEANSKLAALEKLNKELEESKKLTEKEKAELQAKLEAEAKALKEKLAKQAE 453

Query: 294 ELAKLRAEKAAGSKTPATKPANNERSGR--AAQTATRPSQNKG----MRSQLPSTGEAAN 347
ELAKLRA KA+ S+TP KP N G+ A Q T+P+QNK + QLPSTGE AN
Sbjct: 454 ELAKLRAGKASDSQTPDAKPGNKAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETAN 513

Query: 348 PFFTAAAATVMVSAGMLALKRKEE 371
PFFTAAA TVM +AG+ A+ +++E
Sbjct: 514 PFFTAAALTVMATAGVAAVVKRKE 537



Score = 82.4 bits (203), Expect = 2e-19
Identities = 84/303 (27%), Positives = 127/303 (41%), Gaps = 15/303 (4%)

Query: 1 MARQQTKKNYSLRKLKTGTASVAVALTVLGAGFANQTEVRADEAKKMEVKESEKESQYKT 60
M + T ++YSLRKLKTGTASVAVALTVLGAG T + A + + EK
Sbjct: 1 MTKNNTNRHYSLRKLKTGTASVAVALTVLGAGLVVNTNEVSAVATRSQTDTLEK------ 54

Query: 61 LALRGENADLRNVNAKYLEKINAEEEKNKKLEAINKELNENYYKLQDGIDALEKEKEDLK 120
++ K+ + N + KN L NK L ++ +L + + +++
Sbjct: 55 ---------VQERADKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLRKND 105

Query: 121 TTLAKTTKENEISEASRKGLSRDLEASRTAKKELEAKHQKLEAENKKLTEGNQVSEASRK 180
+L++ + + EA + L + LE + AK + LEAE L E + +
Sbjct: 106 KSLSEKASKIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALE 165

Query: 181 GLSNDLEASRAAKKELEAKYQKLETDHQALEAKHQKLEADYQVSETSRKGLSRDLEASRE 240
G N A A K LEA+ LE LE + K L + A
Sbjct: 166 GAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAA 225

Query: 241 ANKKVTSELTQAKAQLSALEESKKLSEKEKAELQAKLDAQGKALKEQLAKQTEELAKLRA 300
+ L A +A K E EKA L+A+ KAL+ + T + AK++
Sbjct: 226 RKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKT 285

Query: 301 EKA 303
+A
Sbjct: 286 LEA 288


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1784GPOSANCHOR845e-20 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 84.0 bits (207), Expect = 5e-20
Identities = 150/306 (49%), Positives = 196/306 (64%), Gaps = 21/306 (6%)

Query: 50 KKEAKLSEAELHDKIKNLEEEKAELFEKLDKVEEEHKKVEEEHKKDHEKLEKKSEDVERH 109
+ A KIK LE EKA L + ++E+ + D K++ +
Sbjct: 234 LEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAA- 292

Query: 110 YLRQLDQEYKEQQERQKNLEELERQSQREVEKRYQEQLQKQQQLEKEKQISEASRKSLSR 169
L + + Q + + R+ + ++ + Q+LE++ +ISEASR+SL R
Sbjct: 293 -LEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRR 351

Query: 170 DLEASRAAKKDLEAEHQKLKEEKQISEASRQGLSRDLEASREAKKKVEADLAEANSKLQA 229
DL+ASR AKK LEAEHQKL+E+ +ISEASRQ L RDL+ASREAKK+VE L EANSKL A
Sbjct: 352 DLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQVEKALEEANSKLAA 411

Query: 230 LEKLNKELEEGKKLSEKEKAELQAKLEAEAKALKEQLAKQAEELAKLK-----GNQTPNA 284
LEKLNKELEE KKL+EKEKAELQAKLEAEAKALKE+LAKQAEELAKL+ +QTP+A
Sbjct: 412 LEKLNKELEESKKLTEKEKAELQAKLEAEAKALKEKLAKQAEELAKLRAGKASDSQTPDA 471

Query: 285 KVAPQA--------------NRSRSAMTQQKRTLPSTGETANPFFTAAAATVMVSAGMLA 330
K +A N++++ M + KR LPSTGETANPFFTAAA TVM +AG+ A
Sbjct: 472 KPGNKAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETANPFFTAAALTVMATAGVAA 531

Query: 331 LKRKEE 336
+ +++E
Sbjct: 532 VVKRKE 537



Score = 50.4 bits (120), Expect = 4e-09
Identities = 68/304 (22%), Positives = 118/304 (38%), Gaps = 7/304 (2%)

Query: 1 MARKDTNKQYSLRKLKTGTASVAVAVAVLGAGFANQTTVKANSKNPVPVKKEAKLSEAEL 60
M + +TN+ YSLRKLKTGTASVAVA+ VLGAG T + K+ E
Sbjct: 1 MTKNNTNRHYSLRKLKTGTASVAVALTVLGAGLVVNTNEVSAVATRSQTDTLEKVQER-- 58

Query: 61 HDKIKNLEEEKAELFEKLDKVEEEHKKVEEEHKKDHEKLEKKSEDVERHYLRQLDQEYKE 120
E E L K + +K +++ + + E+L E + ++ ++ K
Sbjct: 59 ---ADKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLRKNDKSLSEKASKI 115

Query: 121 QQERQKNLEELERQSQREVEKRYQEQLQKQQQLEKEKQISEASRKSLSRDLEASRAAKKD 180
Q+ + + ++ K + LE EK A + L + LE +
Sbjct: 116 QELEARKAD--LEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTA 173

Query: 181 LEAEHQKLKEEKQISEASRQGLSRDLEASREAKKKVEADLAEANSKLQALEKLNKELEEG 240
A+ + L+ EK EA + L + LE + A + ++ AL +LE+
Sbjct: 174 DSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKA 233

Query: 241 KKLSEKEKAELQAKLEAEAKALKEQLAKQAEELAKLKGNQTPNAKVAPQANRSRSAMTQQ 300
+ + AK++ A+QAE L+G + + + +
Sbjct: 234 LEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAAL 293

Query: 301 KRTL 304
+
Sbjct: 294 EAEK 297



Score = 42.0 bits (98), Expect = 2e-06
Identities = 52/206 (25%), Positives = 90/206 (43%), Gaps = 2/206 (0%)

Query: 50 KKEAKLSEAELHDKIKNLEEEKAELFEKLDKVEEEHKKVEEEHKKDHEKLEKKSEDVERH 109
+ A KIK LE EKA L + ++E+ + D K++ +
Sbjct: 164 LEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKA-- 221

Query: 110 YLRQLDQEYKEQQERQKNLEELERQSQREVEKRYQEQLQKQQQLEKEKQISEASRKSLSR 169
L + ++ E N + + +E +Q +LEK + + + S
Sbjct: 222 ALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSA 281

Query: 170 DLEASRAAKKDLEAEHQKLKEEKQISEASRQGLSRDLEASREAKKKVEADLAEANSKLQA 229
++ A K LEAE L+ + Q+ A+RQ L RDL+ASREAKK++EA+ + + +
Sbjct: 282 KIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNKI 341

Query: 230 LEKLNKELEEGKKLSEKEKAELQAKL 255
E + L S + K +L+A+
Sbjct: 342 SEASRQSLRRDLDASREAKKQLEAEH 367


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1785GPOSANCHOR1377e-38 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 137 bits (347), Expect = 7e-38
Identities = 127/353 (35%), Positives = 187/353 (52%), Gaps = 17/353 (4%)

Query: 89 SKLMQQMYKETLQKKEELDTLSKALTHTIEKKIESENAYKKELGQLKAAAEAEAQKALDA 148
+ Q ++ L+ T A T+E + + A K +L + A +
Sbjct: 188 LEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAK 247

Query: 149 LNNKNKQISDLTNENAQLKEAIEGYVQ-------TIQNASREMAAKQQELAAAKSQLEAK 201
+ + + L A+L++A+EG + I+ E AA + E A + Q +
Sbjct: 248 IKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVL 307

Query: 202 NAEIEALKQQDASKTEELAKLQSEAATLENLLGSAKRELTELQAKLDTATAEKAKLESQV 261
NA ++L++ + E +L++E LE ++ L+ LD + K +LE++
Sbjct: 308 NANRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQLEAEH 367

Query: 262 TTLENLLGSAKRELTDLQAKLDAANAEKEKLQSQAAALEKQLEATKKELADLQAKLAATN 321
LE ++ L+ LDA+ K++++ +L A +K +L+ T
Sbjct: 368 QKLEEQNKISEASRQSLRRDLDASREAKKQVEKALEEANSKLAALEKLNKELEESKKLTE 427

Query: 322 QEKE----KLEAEAKALKEQLAKQAEELAKLKADKASGAQKPDTKPGNKEVPTR----PS 373
+EK KLEAEAKALKE+LAKQAEELAKL+A KAS +Q PD KPGNK VP + +
Sbjct: 428 KEKAELQAKLEAEAKALKEKLAKQAEELAKLRAGKASDSQTPDAKPGNKAVPGKGQAPQA 487

Query: 374 QTRTNTNKAPMAQTKRQLPSTGEETTNPFFTAAALTVIASAGVLA-LKRKEEN 425
T+ N NKAPM +TKRQLPSTG ET NPFFTAAALTV+A+AGV A +KRKEEN
Sbjct: 488 GTKPNQNKAPMKETKRQLPSTG-ETANPFFTAAALTVMATAGVAAVVKRKEEN 539



Score = 84.0 bits (207), Expect = 1e-19
Identities = 94/352 (26%), Positives = 154/352 (43%), Gaps = 13/352 (3%)

Query: 1 MSKRNPNKHYSLRKLKTGTASVAVALTVLGAGLANTTDVKAETVGRFSDEQVRKAREKAI 60
M+K N N+HYSLRKLKTGTASVAVALTVLGAGL T+ + R + + K +E+A
Sbjct: 1 MTKNNTNRHYSLRKLKTGTASVAVALTVLGAGLVVNTNEVSAVATRSQTDTLEKVQERA- 59

Query: 61 EDVFDGYTGARSVYQSGNLPNRLTPTKLSKLMQQMYKETLQKKEELDTLSKALTHTIEKK 120
D + + + N L ++ +E KE+L K+L+ K
Sbjct: 60 ----DKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLRKNDKSLSEK-ASK 114

Query: 121 IESENAYKKELGQLKAAAEAEAQKALDALNNKNKQISDLTNENAQLKEAIEGYVQTIQNA 180
I+ A K +L + A + + + + L A L++A+EG + N
Sbjct: 115 IQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAM----NF 170

Query: 181 SREMAAKQQELAAAKSQLEAKNAEIEALKQQDASKTEELAKLQSEAATLENLLGSAKREL 240
S +AK + L A K+ LEA+ AE+E + ++ TLE +
Sbjct: 171 STADSAKIKTLEAEKAALEARQAELEKALEG---AMNFSTADSAKIKTLEAEKAALAARK 227

Query: 241 TELQAKLDTATAEKAKLESQVTTLENLLGSAKRELTDLQAKLDAANAEKEKLQSQAAALE 300
+L+ L+ A +++ TLE + + +L+ L+ A ++ LE
Sbjct: 228 ADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLE 287

Query: 301 KQLEATKKELADLQAKLAATNQEKEKLEAEAKALKEQLAKQAEELAKLKADK 352
+ A + E ADL+ + N ++ L + A +E + E KL+
Sbjct: 288 AEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQN 339



Score = 30.4 bits (68), Expect = 0.016
Identities = 36/203 (17%), Positives = 75/203 (36%)

Query: 160 TNENAQLKEAIEGYVQTIQNASREMAAKQQELAAAKSQLEAKNAEIEALKQQDASKTEEL 219
T+ +++E + + + + A K + E+ K++ + L
Sbjct: 49 TDTLEKVQERADKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLRKNDKSL 108

Query: 220 AKLQSEAATLENLLGSAKRELTELQAKLDTATAEKAKLESQVTTLENLLGSAKRELTDLQ 279
++ S+ LE ++ L +A+ LE++ L ++ L
Sbjct: 109 SEKASKIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAM 168

Query: 280 AKLDAANAEKEKLQSQAAALEKQLEATKKELADLQAKLAATNQEKEKLEAEAKALKEQLA 339
A +A+ + L+++ AALE + +K L A + + + LEAE AL + A
Sbjct: 169 NFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKA 228

Query: 340 KQAEELAKLKADKASGAQKPDTK 362
+ L + + K T
Sbjct: 229 DLEKALEGAMNFSTADSAKIKTL 251


25MGAS10270_Spy1796MGAS10270_Spy1813Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy17962203.161678hypothetical protein
MGAS10270_Spy17972203.194594Fibronectin-binding protein
MGAS10270_Spy17982181.609437Fibronectin-binding protein
MGAS10270_Spy17992322.586282hypothetical cytosolic protein
MGAS10270_Spy18002341.245766Peptidyl-prolyl cis-trans isomerase
MGAS10270_Spy1801021-1.769994hypothetical protein
MGAS10270_Spy1802021-1.163224Streptopain precursor
MGAS10270_Spy1803020-1.648443Streptopain precursor
MGAS10270_Spy1804-119-1.597857hypothetical protein
MGAS10270_Spy18050160.544009hypothetical protein
MGAS10270_Spy18060151.446188Transcriptional regulator
MGAS10270_Spy1807-1224.353825Deoxyribonuclease precursor
MGAS10270_Spy18082244.405936hypothetical protein
MGAS10270_Spy18093234.355854Low temperature requirement C protein
MGAS10270_Spy18102244.092761Glycerol dehydrogenase
MGAS10270_Spy18111213.569803Transaldolase
MGAS10270_Spy18120213.398645Formate acetyltransferase
MGAS10270_Spy18132182.317396PTS system, cellobiose-specific IIC component
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1797IGASERPTASE442e-06 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 43.9 bits (103), Expect = 2e-06
Identities = 49/262 (18%), Positives = 80/262 (30%), Gaps = 23/262 (8%)

Query: 361 KPAEDERSSQATEPANPSKEDSSTDASQGSHDSENPATDSPSQPQAPDQGNHQSQVPNDK 420
+ QA P+ PS + + PAT S + + +S+
Sbjct: 995 TNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVAENSKQESKTVEKN 1054

Query: 421 PQ-----------TDKTDTPNVPAPPQDTPKAPEAGGQSGPAGNTEEKAPDSGPKESDQ- 468
Q K NV A Q T + ++G ++ TE K + KE
Sbjct: 1055 EQDATETTAQNREVAKEAKSNVKANTQ-TNEVAQSGSETKETQTTETKETATVEKEEKAK 1113

Query: 469 ---SSSKESPSVGEDTTPNQPDVLVGGQSEPIDITEDTITDAPPTVSGHNASTQPQSVAE 525
++E P V +P Q QSE + + + PTV+ +Q + A+
Sbjct: 1114 VETEKTQEVPKVTSQVSPKQE------QSETVQPQAEPARENDPTVNIKEPQSQTNTTAD 1167

Query: 526 DTAPQRPDVLVGGQSEPIDITQDTQPGMSGSNDATVINEDTKPKRVFHFDNKEPQASEKA 585
P + Q T +T + N T+P NK ++
Sbjct: 1168 TEQPAKETSSNVEQPVTESTTVNTGNSVV-ENPENTTPATTQPTVNSESSNKPKNRHRRS 1226

Query: 586 AEQKLAPHDSHTTPQTSDDTAA 607
+ TT T A
Sbjct: 1227 VRSVPHNVEPATTSSNDRSTVA 1248



Score = 37.0 bits (85), Expect = 3e-04
Identities = 31/223 (13%), Positives = 64/223 (28%), Gaps = 14/223 (6%)

Query: 237 ELLGLKAEIDQLTKDNPKNDRLETLMWESKFTLSDFRRTSRLSAYYTQEDYVDKVVLSEE 296
E + ++ + T + + D ET + TQ + V + +
Sbjct: 1038 ETVAENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVK----ANTQTNEVAQSGSETK 1093

Query: 297 APNLRTAKEKVKTLKGILYDYYVETNDLEKAKQYRVEDETSPSQPEAPAKPEAPTPSPSP 356
KE K VET ++ + + Q E P P
Sbjct: 1094 ETQTTETKETATVEKE--EKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEPARENDP 1151

Query: 357 APGQKPAEDERSSQATEPANPSKEDSSTDASQGSHDSENPATDSPSQPQAPDQGNHQSQV 416
K + + ++ A P+KE SS + + +S + N ++
Sbjct: 1152 TVNIKEPQSQTNTTADT-EQPAKETSSNVEQPVTESTTVNTGNSVVE-------NPENTT 1203

Query: 417 PNDKPQTDKTDTPNVPAPPQDTPKAPEAGGQSGPAGNTEEKAP 459
P T +++ N P ++ +++
Sbjct: 1204 PATTQPTVNSESSNKPKNRHRRSVRSVPHNVEPATTSSNDRST 1246


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1798IGASERPTASE320.019 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 31.6 bits (71), Expect = 0.019
Identities = 28/140 (20%), Positives = 47/140 (33%), Gaps = 14/140 (10%)

Query: 24 APTVLGQEVSASTTSTETSAASAGVGTSGTAASETGSGAAVATATTTTATTNGGPQSTPA 83
PTV +E + T +T + A +S T S TT T N ++
Sbjct: 1150 DPTVNIKEPQSQTNTTADTEQPAKETSSNVEQPVTES--------TTVNTGNSVVENPEN 1201

Query: 84 VAEATPQPQAQIAPVAAATSTSSASSSSDGKAPQAVTSSTSPSTPAA------ASSNGSN 137
AT QP + S S + T+S++ + A ++N
Sbjct: 1202 TTPATTQPTVNSESSNKPKNRHRRSVRSVPHNVEPATTSSNDRSTVALCDLTSTNTNAVL 1261

Query: 138 QEASAETEPQTMEVEKYTVD 157
+A A+ + + V K
Sbjct: 1262 SDARAKAQFVALNVGKAVSQ 1281


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy179960KDINNERMP250.043 60kDa inner membrane protein signature.
		>60KDINNERMP#60kDa inner membrane protein signature.

Length = 548

Score = 24.9 bits (54), Expect = 0.043
Identities = 4/24 (16%), Positives = 7/24 (29%)

Query: 22 YSKKVLTDEPTGYQPPAAHGPCDD 45
+ + + T AA D
Sbjct: 27 KNPQPQAQQTTQTTTTAAGSAADQ 50


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1802STREPTOPAIN604e-14 Streptopain (C10) cysteine protease family signature.
		>STREPTOPAIN#Streptopain (C10) cysteine protease family signature.

Length = 398

Score = 59.7 bits (144), Expect = 4e-14
Identities = 39/102 (38%), Positives = 56/102 (54%), Gaps = 7/102 (6%)

Query: 2 EMHFVRTEPEARRIAETFCAENTQTKTPMRVQQLSYPSDTDHSGGEL-----YIYALSPA 56
+ +F R E EA+ A TF ++ K R + D + GGEL Y+Y +S
Sbjct: 28 DQNFARNEKEAKDSAITFIQKSAAIKAGARSAE-DIKLDKVNLGGELSGSNMYVYNISTG 86

Query: 57 GFIIVSGDTRAHTILGYSFDNNLDLN-HDNVRSMIEAYQKQI 97
GF+IVSGD R+ ILGYS + D N +N+ S +E+Y +QI
Sbjct: 87 GFVIVSGDKRSPEILGYSTSGSFDANGKENIASFMESYVEQI 128


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1803STREPTOPAIN7100.0 Streptopain (C10) cysteine protease family signature.
		>STREPTOPAIN#Streptopain (C10) cysteine protease family signature.

Length = 398

Score = 710 bits (1833), Expect = 0.0
Identities = 396/398 (99%), Positives = 397/398 (99%)

Query: 1 MNKKKLGIRLLSLLALGGFVLANPVFADQNFARNEKEAKDSAITFIQKSAAIKAGARSAE 60
MNKKKLG+RLLSLLALGGFVLANPVFADQNFARNEKEAKDSAITFIQKSAAIKAGARSAE
Sbjct: 1 MNKKKLGVRLLSLLALGGFVLANPVFADQNFARNEKEAKDSAITFIQKSAAIKAGARSAE 60

Query: 61 DIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASF 120
DIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASF
Sbjct: 61 DIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASF 120

Query: 121 MESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGE 180
MESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGE
Sbjct: 121 MESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGE 180

Query: 181 QSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQY 240
QSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQY
Sbjct: 181 QSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQY 240

Query: 241 NWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQ 300
NWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQ
Sbjct: 241 NWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQ 300

Query: 301 SVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWG 360
SVHQINR DFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWG
Sbjct: 301 SVHQINRGDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWG 360

Query: 361 GVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP 398
GVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP
Sbjct: 361 GVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP 398


26MGAS10270_Spy1832MGAS10270_Spy1853Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy1832-1213.561291Transcriptional regulator ctsR
MGAS10270_Spy18330254.002205Cold shock protein
MGAS10270_Spy1834-1254.244996*Peroxiredoxin
MGAS10270_Spy1835-1265.389153Peroxiredoxin reductase (NAD(P)H) / NADH oxidase
MGAS10270_Spy1836-1245.610471Imidazolonepropionase
MGAS10270_Spy18370276.021852Urocanate hydratase
MGAS10270_Spy1838-1286.163841glutamate formiminotransferase
MGAS10270_Spy1839-1296.260458formiminotetrahydrofolate cyclodeaminase
MGAS10270_Spy1840-1255.550530Formate--tetrahydrofolate ligase
MGAS10270_Spy1841-1244.267066hypothetical cytosolic protein
MGAS10270_Spy1842-2234.192870Amino acid permease
MGAS10270_Spy1843-1223.910112Histidine ammonia-lyase
MGAS10270_Spy18440183.076609Formiminoglutamase
MGAS10270_Spy1845-1172.712446Transcriptional regulator, LuxR family
MGAS10270_Spy1846-1152.780537Transcriptional regulator, LuxR family
MGAS10270_Spy1847-2162.734133SSU ribosomal protein S2P
MGAS10270_Spy1848-2152.732713translation elongation factor Ts (EF-Ts)
MGAS10270_Spy1849-2152.669220Oligoendopeptidase O
MGAS10270_Spy1850-1152.935947Trehalose-6-phosphate hydrolase
MGAS10270_Spy18511143.139116PTS system, trehalose-specific IIBC component /
MGAS10270_Spy18522223.013967Trehalose operon transcriptional repressor
MGAS10270_Spy18531213.527926Transcriptional regulator, MarR family
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1836UREASE477e-08 Urea amidohydrolase (urease) protein signature.
		>UREASE#Urea amidohydrolase (urease) protein signature.

Length = 570

Score = 47.4 bits (113), Expect = 7e-08
Identities = 22/53 (41%), Positives = 32/53 (60%), Gaps = 6/53 (11%)

Query: 46 IAIKDGLIVALG-SGEPDAE-----LVGPQTIMRSYKGKIATPGIIDCHTHLV 92
I +KDG I A+G +G PD + +VGP T + + +GKI T G +D H H +
Sbjct: 88 IGLKDGRIAAIGKAGNPDMQPGVTIIVGPGTEVIAGEGKIVTAGGMDSHIHFI 140


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1849IGASERPTASE310.021 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 30.8 bits (69), Expect = 0.021
Identities = 20/118 (16%), Positives = 35/118 (29%), Gaps = 17/118 (14%)

Query: 438 NAYYDPQQNQIVFPAAILQEPFYSLDQSSSANYGGIGAVIAHEISHAFDT---------N 488
+ + A + S+ N+ +G + + N
Sbjct: 594 YLNLENYTYYALRKGASTRSELPKNSGESNENWLYMGKTSDEAKRNVMNHINNERMNGFN 653

Query: 489 GASFDEHGSLNDWWTQEDYAAFKERTDKIVAQFDGLESHGAKVNGKLTVSENVADLGG 546
G +E G N FK ++++ G G +NG LTV + L G
Sbjct: 654 GYFGEEEGKNNGNLN----VTFKGKSEQNRFLLTG----GTNLNGDLTVEKGTLFLSG 703


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1851RTXTOXIND320.007 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 32.1 bits (73), Expect = 0.007
Identities = 6/18 (33%), Positives = 12/18 (66%)

Query: 610 LVKQGDQVKAGQTLIQFD 627
+VK+G+ V+ G L++
Sbjct: 111 IVKEGESVRKGDVLLKLT 128


27MGAS10270_Spy1874MGAS10270_Spy1892Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy1874321-2.307242DNA integration/recombination/inversion protein
MGAS10270_Spy1875324-1.504403hypothetical protein
MGAS10270_Spy1876423-1.725573phage transcriptional repressor
MGAS10270_Spy1877422-1.293988phage transcriptional regulator, Cro/CI family
MGAS10270_Spy1878424-1.901815phage transcriptional repressor
MGAS10270_Spy1879423-1.987930phage protein
MGAS10270_Spy1880625-2.149347phage protein
MGAS10270_Spy1881624-1.880187phage protein
MGAS10270_Spy1882526-1.453474phage protein
MGAS10270_Spy18835220.175437phage protein
MGAS10270_Spy18845180.415107phage protein
MGAS10270_Spy18855170.557268phage protein
MGAS10270_Spy18864170.232394phage protein
MGAS10270_Spy18873170.077527phage protein
MGAS10270_Spy18882170.210293phage protein
MGAS10270_Spy1889319-0.588372Virulence-associated protein E
MGAS10270_Spy1890627-0.486795phage protein
MGAS10270_Spy1891727-0.645901phage protein
MGAS10270_Spy1892724-0.653939phage protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1877FIMBRILLIN240.040 Porphyromonas gingivalis: fimbrillin protein signature.
		>FIMBRILLIN#Porphyromonas gingivalis: fimbrillin protein signature.

Length = 348

Score = 24.2 bits (52), Expect = 0.040
Identities = 13/54 (24%), Positives = 28/54 (51%), Gaps = 2/54 (3%)

Query: 6 LKAARINAGYTLKQVAGAVGKNPQTISKYEKDSSDISLGLLQKLSSLYGVTIDN 59
L+ R++A ++ V +P ++KY +I + +K S+L+G ++ N
Sbjct: 127 LEIKRVHARMAFTEIK--VQMSPSYVNKYNFAPENIYALVAKKESNLFGASLAN 178


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1889PF05272333e-108 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 333 bits (856), Expect = e-108
Identities = 86/359 (23%), Positives = 141/359 (39%), Gaps = 19/359 (5%)

Query: 26 RGDKEYVISSPYNVGKVFEFYENIYTGIKYNEFEKTIEITKAVPWSKEKGLWTNEQTSLC 85
+ + + + + + ++E + +A PW K G +
Sbjct: 442 LRGRWLLKPRRAALIEALRSAPALAGCVAFDELREQPVAVRAFPWRKAPGPLEDADVLRL 501

Query: 86 IAFIDEKYRF-TPRKEHIEVAITALAKKNTYHPIKQRIESQKWDGKARGERYFIDLLGCA 144
+++ Y + E AI A N HP + +++Q+WD R E++ + +LG
Sbjct: 502 ADYVETTYGTGEASAQTTEQAINVAADMNRVHPFRDWVKAQQWDEVPRLEKWLVHVLGKT 561

Query: 145 DNSYN-------REIAKVWLTGLMARIYLRKVKFEVVPILIDKRQGTGKSTVTKRLLP-S 196
+ Y + + K L G +AR+ KF+ +L + G GKST+ L+
Sbjct: 562 PDDYKPRRLRYLQLVGKYILMGHVARVMEPGCKFDYSVVL-EGTGGIGKSTLINTLVGLD 620

Query: 197 YHTDSEIKFGKNDSDYQKIQANAIIELGELKGMSKAEIETVKSFISSDSDTYREPYERKA 256
+ +D+ G Y++I EL E+ +A+ E VK+F SS D YR Y R
Sbjct: 621 FFSDTHFDIGTGKDSYEQIAGIVAYELSEMTAFRRADAEAVKAFFSSRKDRYRGAYGRYV 680

Query: 257 TPHPRHCVFIGTANKKSFLKDSGTERRFFPIECGINDVKKHPMEVEEDYFLQVLAEAKVW 316
HPR V T NK+ +L D RRF+P+ ++ Q+ AEA
Sbjct: 681 QDHPRQVVIWCTTNKRQYLFDITGNRRFWPVLV-PGRANLVWLQKFRG---QLFAEALHL 736

Query: 317 FNNYEPLTPSKELMNQLADI-QEDYKVEDVDKEIIDQLLNEFQIVEGWDSLSQYEQRQY 374
+ E PS E QE VE + + LL EG + Q+ Y
Sbjct: 737 YLAGERYFPSPEDEEIYFRPEQELRLVETGVQGRLWALLTR----EGAPAAEGAAQKGY 791


28MGAS10270_Spy1906MGAS10270_Spy1929Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy1906013-3.520449Histidyl-tRNA synthetase
MGAS10270_Spy1907121-4.891450LSU ribosomal protein L32P
MGAS10270_Spy1908120-4.891882LSU ribosomal protein L33P
MGAS10270_Spy1909219-3.306505Cadmium resistance protein
MGAS10270_Spy1910221-2.579779Cadmium efflux system accessory protein
MGAS10270_Spy1911218-2.280373hypothetical protein
MGAS10270_Spy1912222-0.241903hypothetical protein
MGAS10270_Spy1913119-1.540722hypothetical protein
MGAS10270_Spy1914218-1.462733FtsK/SpoIIIE family
MGAS10270_Spy1915317-1.907346hypothetical protein
MGAS10270_Spy1916317-2.173888Replication protein
MGAS10270_Spy1917419-2.184403phage protein
MGAS10270_Spy1918317-1.100318DNA integration/recombination/inversion protein
MGAS10270_Spy19195200.148834Integral membrane protein
MGAS10270_Spy19202170.651459Phosphohydrolase
MGAS10270_Spy19211150.025692hypothetical protein
MGAS10270_Spy19221150.078610Transcriptional regulator, PadR family
MGAS10270_Spy19231140.001218hypothetical membrane associated protein
MGAS10270_Spy1924215-0.779384hypothetical membrane associated protein
MGAS10270_Spy1925015-1.204975phage infection protein
MGAS10270_Spy1926120-4.217609Transcriptional regulator, TetR family
MGAS10270_Spy1927223-4.131727RelE protein
MGAS10270_Spy1928325-3.736980RelB protein
MGAS10270_Spy1929224-3.099098phage encoded transcriptional regulator, ArpU
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1925GPOSANCHOR330.004 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 33.1 bits (75), Expect = 0.004
Identities = 24/188 (12%), Positives = 56/188 (29%), Gaps = 7/188 (3%)

Query: 265 RLSQGASQLNQGLSQLTQSTTLSDDKAKRIQSLEVGLPVLNQGIQQLNANLSTMQVPKLN 324
R + L ++ T + +L L + ++ +
Sbjct: 121 RKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKT 180

Query: 325 TDELGNNLAAIAQAAQQLLVKEAAAHKEQLAVLQATSAYQSLTAEQQGELTAALTQTDKG 384
+ L A ++ L A ++ A ++ A ++ +L AL
Sbjct: 181 LEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALE----- 235

Query: 385 EAVAPAQTILRSVQTLSTSLQSLSQEDQSKQLEQLKEAVAQIANQSNQALPGASSALTEL 444
A+ + ++TL +L E + +LE+ E + + + + L
Sbjct: 236 GAMNFSTADSAKIKTLEAEKAAL--EARQAELEKALEGAMNFSTADSAKIKTLEAEKAAL 293

Query: 445 STGLAKVN 452
A +
Sbjct: 294 EAEKADLE 301


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1926HTHTETR476e-09 TetR bacterial regulatory protein HTH signature.
		>HTHTETR#TetR bacterial regulatory protein HTH signature.

Length = 215

Score = 46.9 bits (111), Expect = 6e-09
Identities = 14/53 (26%), Positives = 28/53 (52%)

Query: 4 RKENTKQAILKAMVMLLKTESFDDITTVKLSKRAGISRSSFYTHYKDKYEMID 56
+ T+Q IL + L + + +++K AG++R + Y H+KDK ++
Sbjct: 8 EAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFS 60


29MGAS10270_Spy0089MGAS10270_Spy0096N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy0089220-3.899628ComG operon protein 2
MGAS10270_Spy0090020-2.914395ComG operon protein 3
MGAS10270_Spy0091-214-1.868574ComG operon protein 4
MGAS10270_Spy0092-115-1.632617ComG operon protein 5
MGAS10270_Spy0093-214-0.409576ComG operon protein 6
MGAS10270_Spy0094-2151.601373ComG operon protein 6
MGAS10270_Spy0095-2151.892743Adenine-specific methyltransferase
MGAS10270_Spy0096-1182.385288Acetate kinase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0089BCTERIALGSPF904e-22 Bacterial general secretion pathway protein F signa...
		>BCTERIALGSPF#Bacterial general secretion pathway protein F

signature.
Length = 408

Score = 89.9 bits (223), Expect = 4e-22
Identities = 65/341 (19%), Positives = 135/341 (39%), Gaps = 22/341 (6%)

Query: 37 KKLSSKHQHKFIQLLANLLSTGFSFAEVIAFLKRS--QLLQLDYVLKMEESLLKGQGLAD 94
+LS+ + LA L++ E + + + + + + +++G LAD
Sbjct: 63 IRLSTSDLALLTRQLATLVAASMPLEEALDAVAKQSEKPHLSQLMAAVRSKVMEGHSLAD 122

Query: 95 MLSGLG--FSDAILTQISLADRHGNIETTLVAIQHYLNQMARIRRKTVEVITYPLILLLF 152
+ F ++ + G+++ L + Y Q ++R + + + YP +L +
Sbjct: 123 AMKCFPGSFERLYCAMVAAGETSGHLDAVLNRLADYTEQRQQMRSRIQQAMIYPCVLTVV 182

Query: 153 LFVMMLGLRRYLVPQLETQNQ---------------ITYFLNHFPAFFIGFCSGLILLFG 197
++ L +VP++ Q ++ + F + + + F
Sbjct: 183 AIAVVSILLSVVVPKVVEQFIHMKQALPLSTRVLMGMSDAVRTFGPWMLLALLAGFMAFR 242

Query: 198 MVWLRWRSQSRLKLYSRLSRYPFLGKLLKQYLTSYYAREWGTLIGQGLDLMAILDIMAIE 257
+ LR + + R+ + RL P +G++ + T+ YAR L + L+ + I
Sbjct: 243 V-MLR-QEKRRVSFHRRLLHLPLIGRIARGLNTARYARTLSILNASAVPLLQAMRISGDV 300

Query: 258 KSSL-MKELAEDIRMSLLEGQAFHIKVATYPFFKKELSLMIEYGEIKSKLGAELEIYAQE 316
S+ + ++ EG + H + F + MI GE +L + LE A
Sbjct: 301 MSNDYARHRLSLATDAVREGVSLHKALEQTALFPPMMRHMIASGERSGELDSMLERAADN 360

Query: 317 SWEQFFSQLYQVTQLIQPAIFLVVAVTIVMIYAAILLPIYQ 357
+F SQ+ L +P + + +A ++ I AIL PI Q
Sbjct: 361 QDREFSSQMTLALGLFEPLLVVSMAAVVLFIVLAILQPILQ 401



Score = 34.8 bits (80), Expect = 5e-04
Identities = 32/129 (24%), Positives = 60/129 (46%), Gaps = 6/129 (4%)

Query: 235 REWGTLIGQGLDLMAILDIMAIE-KSSLMKELAEDIRMSLLEGQAFHIKVATYP-FFKKE 292
R+ TL+ + L LD +A + + + +L +R ++EG + + +P F++
Sbjct: 75 RQLATLVAASMPLEEALDAVAKQSEKPHLSQLMAAVRSKVMEGHSLADAMKCFPGSFERL 134

Query: 293 LSLMIEYGEIKSKLGAELEIYA--QESWEQFFSQLYQVTQLIQPAIFLVVAVTIVMIYAA 350
M+ GE L A L A E +Q S++ Q +I P + VVA+ +V I +
Sbjct: 135 YCAMVAAGETSGHLDAVLNRLADYTEQRQQMRSRIQQA--MIYPCVLTVVAIAVVSILLS 192

Query: 351 ILLPIYQNM 359
+++P
Sbjct: 193 VVVPKVVEQ 201


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0090BCTERIALGSPG534e-12 Bacterial general secretion pathway protein G signa...
		>BCTERIALGSPG#Bacterial general secretion pathway protein G

signature.
Length = 145

Score = 52.6 bits (126), Expect = 4e-12
Identities = 28/94 (29%), Positives = 50/94 (53%), Gaps = 4/94 (4%)

Query: 9 RHKKLKGFTLLEMLLVILVISVLMLLFVPNLSKQKDRVTETGNAAVVKLVENQAELYELS 68
K +GFTLLE+++VI++I VL L VPNL K++ + + + +EN ++Y+L
Sbjct: 3 ATDKQRGFTLLEIMVVIVIIGVLASLVVPNLMGNKEKADKQKAVSDIVALENALDMYKLD 62

Query: 69 QGSKPSLSQ-LKA--DGSITEKQEKAY-QDYYDK 98
P+ +Q L++ + Y ++ Y K
Sbjct: 63 NHHYPTTNQGLESLVEAPTLPPLAANYNKEGYIK 96


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0093OMPTIN270.035 Omptin serine protease signature.
		>OMPTIN#Omptin serine protease signature.

Length = 317

Score = 26.9 bits (59), Expect = 0.035
Identities = 17/71 (23%), Positives = 25/71 (35%), Gaps = 9/71 (12%)

Query: 37 LLKRSHYLARHDQDNWLLFSHQL--REELSGARFYKVADNK-LYVEKGKKVLAFGQFKSH 93
K S ++ D D ++ R ++ +Y VA N YV KV G +
Sbjct: 217 TFKYSGWVESSDNDEHYDPGKRITYRSKVKDQNYYSVAVNAGYYVTPNAKVYVEGAWNRV 276

Query: 94 DFRKSASNGKG 104
N KG
Sbjct: 277 T------NKKG 281


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0096ACETATEKNASE500e-179 Acetate kinase family signature.
		>ACETATEKNASE#Acetate kinase family signature.

Length = 400

Score = 500 bits (1288), Expect = e-179
Identities = 209/401 (52%), Positives = 281/401 (70%), Gaps = 7/401 (1%)

Query: 3 KTIAINAGSSSLKWQLYQMPEEAVLAQGIIERIGLKDSISTVKYDGKKEEQILDIHDHTE 62
K + IN GSSSLK+QL + + VLA+G+ ERIG+ DS+ T +G+K + D+ DH +
Sbjct: 2 KILVINCGSSSLKYQLIESKDGNVLAKGLAERIGINDSLLTHNANGEKIKIKKDMKDHKD 61

Query: 63 AVKILLNDLI--HFGIIAAYDEITGVGHRVVAGGELFKESVVVNDKVLEHIEELSVLAPL 120
A+K++L+ L+ +G+I EI VGHRVV GGE F SV++ D VL+ I + LAPL
Sbjct: 62 AIKLVLDALVNSDYGVIKDMSEIDAVGHRVVHGGEYFTSSVLITDDVLKAITDCIELAPL 121

Query: 121 HNPGAAAGIRAFRDILPDITSVCVFDTSFHTSMAKHTYLYPIPQKYYTDYKVRKYGAHGT 180
HNP GI+A I+PD+ V VFDT+FH +M + YLYPIP +YYT YK+RKYG HGT
Sbjct: 122 HNPANIEGIKACTQIMPDVPMVAVFDTAFHQTMPDYAYLYPIPYEYYTKYKIRKYGFHGT 181

Query: 181 SHKYVAQEAAKMLGRPLEELKLITAHIGNGVSITANYHGKSVDTSMGFTPLAGPMMGTRS 240
SHKYV+Q AA++L +P+E LK+IT H+GNG SI A +GKS+DTSMGFTPL G MGTRS
Sbjct: 182 SHKYVSQRAAEILNKPIESLKIITCHLGNGSSIAAVKNGKSIDTSMGFTPLEGLAMGTRS 241

Query: 241 GDIDPAIIPYLIEQDPELKDAADVVNMLNKKSGLSGVSGISSDMRDI-EAGLQEDNPDAV 299
G IDP+II YL+E+ E A +VVN+LNKKSG+ G+SGISSD RD+ +A + + A
Sbjct: 242 GSIDPSIISYLMEK--ENISAEEVVNILNKKSGVYGISGISSDFRDLEDAAFKNGDKRAQ 299

Query: 300 LAYNIFIDRIKKCIGQYFAVLNGADALVFTAGMGENAPLMRQDVIGGLTWFGMDIDPEKN 359
LA N+F R+KK IG Y A + G D +VFTAG+GEN P +R+ ++ GL + G +D EKN
Sbjct: 300 LALNVFAYRVKKTIGSYAAAMGGVDVIVFTAGIGENGPEIREFILDGLEFLGFKLDKEKN 359

Query: 360 -VFGYRGDISTPESKVKVLVISTDEELCIARDVERL-KNTK 398
V G IST +SKV V+V+ T+EE IA+D E++ ++ K
Sbjct: 360 KVRGEEAIISTADSKVNVMVVPTNEEYMIAKDTEKIVESLK 400


30MGAS10270_Spy0284MGAS10270_Spy0291N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy0284-110-1.114839GTP-binding protein
MGAS10270_Spy0285111-2.017820SWF/SNF family helicase
MGAS10270_Spy0286-110-1.255761hypothetical cytosolic protein
MGAS10270_Spy0287-310-1.105983UDP-N-acetylmuramate--alanine ligase
MGAS10270_Spy0288-112-0.367046Acetyltransferase, GNAT family
MGAS10270_Spy0289-111-0.344054hypothetical membrane associated protein
MGAS10270_Spy0290-2130.028018Transcription elongation factor greA
MGAS10270_Spy02910130.18311560 kDa inner membrane protein YIDC
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0284TCRTETOQM371e-04 Tetracycline resistance protein TetO/TetQ/TetM family ...
		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

signature.
Length = 639

Score = 37.1 bits (86), Expect = 1e-04
Identities = 21/87 (24%), Positives = 40/87 (45%), Gaps = 8/87 (9%)

Query: 36 GVTRDRIYATGEWLNRQFSLIDTGGIDDVDAPFMEQIKHQAQIAMEEADVIVFVVSGKEG 95
G+T + +W N + ++IDT G D F+ ++ ++ D + ++S K+G
Sbjct: 53 GITIQTGITSFQWENTKVNIIDTPGHMD----FLAEVYR----SLSVLDGAILLISAKDG 104

Query: 96 VTDADEYVSKILYRTNTPVILAVNKVD 122
V + L + P I +NK+D
Sbjct: 105 VQAQTRILFHALRKMGIPTIFFINKID 131


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0287ACETATEKNASE310.008 Acetate kinase family signature.
		>ACETATEKNASE#Acetate kinase family signature.

Length = 400

Score = 31.3 bits (71), Expect = 0.008
Identities = 16/55 (29%), Positives = 24/55 (43%), Gaps = 9/55 (16%)

Query: 304 IINDTII--IDDFA-----HHPTEIVATIDAARQKYPSKEIVAIFQPHTFTRTIA 351
+I D ++ I D H+P I I A Q P +VA+F F +T+
Sbjct: 103 LITDDVLKAITDCIELAPLHNPANIEG-IKACTQIMPDVPMVAVFDT-AFHQTMP 155


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0288SACTRNSFRASE327e-04 Streptothricin acetyltransferase signature.
		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

Length = 173

Score = 31.8 bits (72), Expect = 7e-04
Identities = 26/120 (21%), Positives = 45/120 (37%), Gaps = 29/120 (24%)

Query: 46 VALIDQEIVGYIEGPVVTTPILEDSLFHGVTKNPKTGGYIAITSLSIAKHFQQQGVGTAL 105
+ ++ +G I+ + N GY I +++AK ++++GVGTAL
Sbjct: 69 LYYLENNCIGRIK----------------IRSN--WNGYALIEDIAVAKDYRKKGVGTAL 110

Query: 106 LAALKDLVVAQQRTGLILTCHDYLIS---YYEMNGFINQGISESQHGGT--------LWY 154
L + GL+L D IS +Y + FI + + WY
Sbjct: 111 LHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGAVDTMLYSNFPTANEIAIFWY 170


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy029160KDINNERMP1362e-38 60kDa inner membrane protein signature.
		>60KDINNERMP#60kDa inner membrane protein signature.

Length = 548

Score = 136 bits (344), Expect = 2e-38
Identities = 68/231 (29%), Positives = 113/231 (48%), Gaps = 22/231 (9%)

Query: 38 WEFLGKPMSYFIDYFANNAGLGYGLAIIIVTIIVRTLILPLGLYQSWKASYQS-EKMTFL 96
F+ +P+ + + + G +G +III+T IVR ++ PL KA Y S KM L
Sbjct: 333 LWFISQPLFKLLKWIHSFVG-NWGFSIIIITFIVRGIMYPLT-----KAQYTSMAKMRML 386

Query: 97 KPVFEPINKRIKQASSQEEKMAAQTELMAAQRAHGINPLGGIGCLPLLIQMPFFSAMYFA 156
+P + + +R+ ++K E+MA +A +NPLGG C PLLIQMP F A+Y+
Sbjct: 387 QPKIQAMRERLG-----DDKQRISQEMMALYKAEKVNPLGG--CFPLLIQMPIFLALYYM 439

Query: 157 AQYTKGVSTSTFM----SIDLGSRSLVLTAIIAALYFFQSWLSMMAVSEEQREQMKTMMY 212
+ + + F + +L ++ FF +S V++ + +M
Sbjct: 440 LMGSVELRQAPFALWIHDLSAQDPYYILPILMGVTMFFIQKMSPTTVTDPM---QQKIMT 496

Query: 213 TMPIMMIFMSFSLPAGVGLYWLVGGFFSIIQQ-LITTYLLKPRLHKQIKEE 262
MP++ P+G+ LY++V +IIQQ LI L K LH + K++
Sbjct: 497 FMPVIFTVFFLWFPSGLVLYYIVSNLVTIIQQQLIYRGLEKRGLHSREKKK 547


31MGAS10270_Spy0589MGAS10270_Spy0597N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy05894262.883227phage endopeptidase
MGAS10270_Spy05905252.414586Hyaluronoglucosaminidase
MGAS10270_Spy05915253.497422phage infection protein
MGAS10270_Spy0592120-0.378762phage protein
MGAS10270_Spy0593020-0.356651phage protein
MGAS10270_Spy05940130.182656phage protein
MGAS10270_Spy0595-1130.269644Holin
MGAS10270_Spy0596-2100.085748phage-associated cell wall hydrolase
MGAS10270_Spy0597-310-0.348704Enterotoxin
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0589SSPAMPROTEIN290.036 Salmonella surface presentation of antigen gene typ...
		>SSPAMPROTEIN#Salmonella surface presentation of antigen gene type M

signature.
Length = 147

Score = 28.9 bits (64), Expect = 0.036
Identities = 23/65 (35%), Positives = 29/65 (44%), Gaps = 6/65 (9%)

Query: 387 ERINALENNQKVITNNQKQFELNLPKYLNDINGKRVWYEKPDDNIEHKIGDYWFEKNGKY 446
E I AL Q ++ K EL + + I KR EK + + K YW K G Y
Sbjct: 66 EEIYALLRKQSIVRRQIKDLELQIIQ----IQEKRSELEKKREEFQEK-SKYWLRKEGNY 120

Query: 447 QRTWI 451
QR WI
Sbjct: 121 QR-WI 124


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0590PF072125630.0 Hyaluronoglucosaminidase
		>PF07212#Hyaluronoglucosaminidase

Length = 336

Score = 563 bits (1452), Expect = 0.0
Identities = 336/336 (100%), Positives = 336/336 (100%)

Query: 1 MTETIPLRVQFKRMTAEEWTRSDVILLESEIGFETDTGYAKFGDGKNQFSKLKYLNKPDL 60
MTETIPLRVQFKRMTAEEWTRSDVILLESEIGFETDTGYAKFGDGKNQFSKLKYLNKPDL
Sbjct: 1 MTETIPLRVQFKRMTAEEWTRSDVILLESEIGFETDTGYAKFGDGKNQFSKLKYLNKPDL 60

Query: 61 GAFAQKEETNSKITKLESSKADKNAVYLKAESKIELDKKLNLKGGVMTGQLQFKPNKSGI 120
GAFAQKEETNSKITKLESSKADKNAVYLKAESKIELDKKLNLKGGVMTGQLQFKPNKSGI
Sbjct: 61 GAFAQKEETNSKITKLESSKADKNAVYLKAESKIELDKKLNLKGGVMTGQLQFKPNKSGI 120

Query: 121 KPSSSVGGAINIDMSKSEGAGVVVYSNNDTSDGPLMSLRTGKETFNQSALFVDYSGKTNA 180
KPSSSVGGAINIDMSKSEGAGVVVYSNNDTSDGPLMSLRTGKETFNQSALFVDYSGKTNA
Sbjct: 121 KPSSSVGGAINIDMSKSEGAGVVVYSNNDTSDGPLMSLRTGKETFNQSALFVDYSGKTNA 180

Query: 181 VNIAMRQPTTPNFSSALNITSGNENGSAMQIRGVEKALGTLKITHENPNVEANYDENAAA 240
VNIAMRQPTTPNFSSALNITSGNENGSAMQIRGVEKALGTLKITHENPNVEANYDENAAA
Sbjct: 181 VNIAMRQPTTPNFSSALNITSGNENGSAMQIRGVEKALGTLKITHENPNVEANYDENAAA 240

Query: 241 LSIDIVKKQKGGKGTAAQGIYINSTSGTTGKLLRIRNLGDDKFYVKHDGGFYAKKTSQID 300
LSIDIVKKQKGGKGTAAQGIYINSTSGTTGKLLRIRNLGDDKFYVKHDGGFYAKKTSQID
Sbjct: 241 LSIDIVKKQKGGKGTAAQGIYINSTSGTTGKLLRIRNLGDDKFYVKHDGGFYAKKTSQID 300

Query: 301 GNLKLKNPTADDHAATKAYVDSEVKKLKALLMDKQV 336
GNLKLKNPTADDHAATKAYVDSEVKKLKALLMDKQV
Sbjct: 301 GNLKLKNPTADDHAATKAYVDSEVKKLKALLMDKQV 336


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0591RTXTOXIND340.003 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 33.6 bits (77), Expect = 0.003
Identities = 27/145 (18%), Positives = 51/145 (35%), Gaps = 21/145 (14%)

Query: 158 RLSSSYQSGINGLKAQLANDKI---GLQAEIQATAQGLSQKYDNELRQLSAKITTTSSGT 214
RL+S + + + Q ++ +AE T +Y+N R +++ SS
Sbjct: 186 RLTSLIKEQFSTWQNQKYQKELNLDKKRAERL-TVLARINRYENLSRVEKSRLDDFSSLL 244

Query: 215 TEAYESKLAGLRAEFTRSNQGMRIELESQISGLRAVQQSTASQISQEIRDRTGAVSRVQQ 274
+ +K A L E E++ + SQ+ Q + A Q
Sbjct: 245 HKQAIAKHAVL-------------EQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQL 291

Query: 275 DLESYQR----RLQDAEDNYSSLTH 295
+ ++ +L+ DN LT
Sbjct: 292 VTQLFKNEILDKLRQTTDNIGLLTL 316


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0596FLGFLGJ977e-25 Flagellar protein FlgJ signature.
		>FLGFLGJ#Flagellar protein FlgJ signature.

Length = 313

Score = 97.1 bits (241), Expect = 7e-25
Identities = 46/123 (37%), Positives = 65/123 (52%), Gaps = 8/123 (6%)

Query: 23 SLTAAQAILESGWGKHA-------PHNALFGIKADASWTGKSFNTKTQEEYQAGVITDIV 75
L AQA LESGWG+ P LFG+KA +W G T E Y+ G +
Sbjct: 172 HLILAQAALESGWGQRQIRRENGEPSYNLFGVKASGNWKGPVTEITTTE-YENGEAKKVK 230

Query: 76 DRFRAYDSWDESIADHGQFLVDNPRYQSVIGEADYKKACHAIKDAGYATASGYAELLIQI 135
+FR Y S+ E+++D+ L NPRY +V A ++ A++DAGYAT YA L +
Sbjct: 231 AKFRVYSSYLEALSDYVGLLTRNPRYAAVTTAASAEQGAQALQDAGYATDPHYARKLTNM 290

Query: 136 IEE 138
I++
Sbjct: 291 IQQ 293


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0597BACTRLTOXIN1714e-55 Bacterial toxin signature.
		>BACTRLTOXIN#Bacterial toxin signature.

Length = 266

Score = 171 bits (435), Expect = 4e-55
Identities = 61/254 (24%), Positives = 117/254 (46%), Gaps = 28/254 (11%)

Query: 6 IIKIVFIITVILISTISPIIKSDSKKDISNVKSDLLYAYTITPYDYKDCRVNFSTT---- 61
+I I +I VI + + D D + S+ Y Y D V+ +
Sbjct: 10 VILIFALILVISTPNVLAESQPDPMPDDLHKSSEFTGTMGNMKYLYDDHYVSATKVKSVD 69

Query: 62 ----HTL--NIDTQKYRGKDYYISSEMSYEASQKFKRDDHVDVFGLFYILNSHTGEY--- 112
H L NI +K + D + ++ + ++K+K D+ VDV+G Y +N +
Sbjct: 70 KFLAHDLIYNISDKKLKNYDKVKTELLNEDLAKKYK-DEVVDVYGSNYYVNCYFSSKDNV 128

Query: 113 ---------IYGGITPAQNNKVNHKLLGNLFIS-GESQQN-LNNKIILEKDIVTFQEIDF 161
+YGGIT + N ++ L N+ + E+++N ++ ++ +K VT QE+D
Sbjct: 129 GKVTGGKTCMYGGITKHEGNHFDNGNLQNVLVRVYENKRNTISFEVQTDKKSVTAQELDI 188

Query: 162 KIRKYLMDNYKIYD-ATSPYVSGRIEIGTKDGKHEQIDLFDSPNEG-TRSDIFAKYKDNR 219
K R +L++ +Y+ +SPY +G I+ +G D+ +P + +S Y DN+
Sbjct: 189 KARNFLINKKNLYEFNSSPYETGYIKFIENNGNTFWYDMMPAPGDKFDQSKYLMMYNDNK 248

Query: 220 IINMKNFSHFDIYL 233
++ K+ +++L
Sbjct: 249 TVDSKS-VKIEVHL 261


32MGAS10270_Spy0840MGAS10270_Spy0845N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy08403181.314487phage protein
MGAS10270_Spy08414161.008327phage structural protein
MGAS10270_Spy0842518-0.780408phage protein
MGAS10270_Spy0843521-0.532277phage protein
MGAS10270_Spy0844521-0.098773phage protein
MGAS10270_Spy0845620-0.175448N-acetylmuramoyl-L-alanine amidase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0840FLGFLGJ396e-05 Flagellar protein FlgJ signature.
		>FLGFLGJ#Flagellar protein FlgJ signature.

Length = 313

Score = 39.3 bits (91), Expect = 6e-05
Identities = 32/139 (23%), Positives = 56/139 (40%), Gaps = 9/139 (6%)

Query: 294 VFSQLYLESFWGDTPVGRAD----NNWGGI----TWTGATTRPSGINVSQGQPRAEGGHY 345
+ +Q LES WG + R + N G+ W G T + G+ + +
Sbjct: 174 ILAQAALESGWGQRQIRRENGEPSYNLFGVKASGNWKGPVTEITTTEYENGEAKKVKAKF 233

Query: 346 NHYASVDDYLKDYTYLLAEQGIY-AVKGKLTIDEYTRGLFRVGGATYDYAAAGYDHYAPL 404
Y+S + L DY LL Y AV + ++ + L G AT + A +
Sbjct: 234 RVYSSYLEALSDYVGLLTRNPRYAAVTTAASAEQGAQALQDAGYATDPHYARKLTNMIQQ 293

Query: 405 MRDIRAGINRNNNGAMDNV 423
M+ I +++ + +DN+
Sbjct: 294 MKSISDKVSKTYSMNIDNL 312


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0843CARBMTKINASE260.007 Bacterial carbamate kinase signature.
		>CARBMTKINASE#Bacterial carbamate kinase signature.

Length = 314

Score = 25.9 bits (57), Expect = 0.007
Identities = 13/41 (31%), Positives = 18/41 (43%), Gaps = 14/41 (34%)

Query: 25 EFGWITLEDVPKKYR--------------DKVKQLVESGNI 51
E GWI ED + +R + +K+LVE G I
Sbjct: 148 EKGWIVKEDSGRGWRRVVPSPDPKGHVEAETIKKLVERGVI 188


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0844FRAGILYSIN290.004 Fragilysin metallopeptidase (M10C) enterotoxin signat...
		>FRAGILYSIN#Fragilysin metallopeptidase (M10C) enterotoxin

signature.
Length = 405

Score = 28.9 bits (64), Expect = 0.004
Identities = 15/63 (23%), Positives = 25/63 (39%), Gaps = 5/63 (7%)

Query: 25 VSAPVKHVLDNNKKAMEALESAIVKISDD-----LKDNNFKWTESKNHRDRLQKVQDQHE 79
+ APV +D + L + + +SD LKDN F + R + D
Sbjct: 38 IDAPVTASIDLQSVSYTDLATQLNDVSDFGKMIILKDNGFNRQVHVSMDKRTKIQLDNEN 97

Query: 80 IRI 82
+R+
Sbjct: 98 VRL 100


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy0845UREASE280.009 Urea amidohydrolase (urease) protein signature.
		>UREASE#Urea amidohydrolase (urease) protein signature.

Length = 570

Score = 27.8 bits (62), Expect = 0.009
Identities = 11/54 (20%), Positives = 21/54 (38%), Gaps = 5/54 (9%)

Query: 46 VARNAVEAVEQIAYDKDIK---GIEKLTEAKIAVRDELSKHNVYLSDK--QMEV 94
++V V Q + D + G+ K A R + K ++ + +EV
Sbjct: 486 RTNSSVTFVSQASLDAGLAGRLGVAKELVAVQNTRGGIGKASMIHNSLTPHIEV 539


33MGAS10270_Spy1266MGAS10270_Spy1282N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy1266-2141.048408Cell division protein ftsA
MGAS10270_Spy1267-1161.148191Cell-division initiation protein DivIB
MGAS10270_Spy1268-2152.144839UDP-N-acetylglucosamine--N-acetylmuramyl-
MGAS10270_Spy1269-1181.857870UDP-N-acetylmuramoylalanine--D-glutamate ligase
MGAS10270_Spy12701231.933884hypothetical membrane spanning protein
MGAS10270_Spy1271-1191.140338GTP-binding protein TypA/BipA
MGAS10270_Spy1272013-0.442140Rhodanese-related sulfurtransferases
MGAS10270_Spy1273-113-1.257573Glucokinase
MGAS10270_Spy1274417-3.270155hypothetical cytosolic protein
MGAS10270_Spy1275216-2.722797Non-specific DNA-binding protein Dps /
MGAS10270_Spy1276219-2.740645Type 4 prepilin peptidase pilD
MGAS10270_Spy1277018-2.493229Radical SAM family enzyme
MGAS10270_Spy1278018-2.469394hypothetical cytosolic protein
MGAS10270_Spy1279-116-0.949631hypothetical protein
MGAS10270_Spy1280-2140.087542Ribose operon repressor
MGAS10270_Spy1281-2141.088557ATP-dependent endopeptidase Lon
MGAS10270_Spy12821141.491491Phosphopantetheine adenylyltransferase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1266SHAPEPROTEIN475e-08 Bacterial cell shape determinant MreB/Mbl protein s...
		>SHAPEPROTEIN#Bacterial cell shape determinant MreB/Mbl protein

signature.
Length = 347

Score = 47.4 bits (113), Expect = 5e-08
Identities = 42/191 (21%), Positives = 79/191 (41%), Gaps = 16/191 (8%)

Query: 170 RKTVERAGIKVENIIISPLAMAKTILNEGEREFGATVIDMGGGQTTVASMRAQELQYTNI 229
R++ + AG + +I P+A A G+ V+D+GGG T VA + + Y++
Sbjct: 127 RESAQGAGAREVFLIEEPMAAAIGAGLPVSEATGSMVVDIGGGTTEVAVISLNGVVYSSS 186

Query: 230 YAEGGEYITKDISKVLKTSLAI------AEALKFNFGQAEISEASITETVK-VDVV-GSE 281
GG+ + I ++ + AE +K G A + V+ ++ G
Sbjct: 187 VRIGGDRFDEAIINYVRRNYGSLIGEATAERIKHEIGSAYPGDEVREIEVRGRNLAEGVP 246

Query: 282 EPVEVTERYLSEIISARIRHILDRVKQDLER------GRLLDLPGGIVLIGGGAIMPGVV 335
+ + E + + I+ V LE+ + + G+VL GGGA++ +
Sbjct: 247 RGFTLNSNEILEALQEPLTGIVSAVMVALEQCPPELASDISE--RGMVLTGGGALLRNLD 304

Query: 336 EIAQEIFGVTV 346
+ E G+ V
Sbjct: 305 RLLMEETGIPV 315


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1268LIPPROTEIN48310.010 Mycoplasma P48 major surface lipoprotein signature.
		>LIPPROTEIN48#Mycoplasma P48 major surface lipoprotein signature.

Length = 428

Score = 30.7 bits (69), Expect = 0.010
Identities = 19/99 (19%), Positives = 31/99 (31%), Gaps = 10/99 (10%)

Query: 154 FEQEDQLSKVKHLGAVTKVFKDANQMPESTQLE-AVKEYFSRDLKTLLFIGGSAGAHVFN 212
FE ++K + + N + S+ E A S K + G
Sbjct: 83 FEALKAINKQTGI--------EINNVEPSSNFESAYNSALSAGHKIWVLNGFKHQQS-IK 133

Query: 213 QFISDHPELKQRYNIINITGDPHLNELSSHLYRVDYVTD 251
Q+I H E +R I I D + Y + +
Sbjct: 134 QYIDAHREELERNQIKIIGIDFDIETEYKWFYSLQFNIK 172


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1271TCRTETOQM1864e-53 Tetracycline resistance protein TetO/TetQ/TetM family ...
		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

signature.
Length = 639

Score = 186 bits (473), Expect = 4e-53
Identities = 102/477 (21%), Positives = 187/477 (39%), Gaps = 97/477 (20%)

Query: 8 IRNVAIIAHVDHGKTTLVDELLKQSHTLDERKELQE--RAMDSNDLEKERGITILAKNTA 65
I N+ ++AHVD GKTTL + LL S + E + + D+ LE++RGITI T+
Sbjct: 3 IINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGITS 62

Query: 66 VAYNDVRINIMDTPGHADFGGEVERIMKMVDGVVLVVDAYEGTMPQTRFVLKKALEQNLI 125
+ + ++NI+DTPGH DF EV R + ++DG +L++ A +G QTR + + +
Sbjct: 63 FQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALRKMGIP 122

Query: 126 PIVVVNKIDKPSARP-------------------------------------AEVVDEVL 148
I +NKID+ + V E
Sbjct: 123 TIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVELYPNMCVTNFTESEQWDTVIEGN 182

Query: 149 ELFIELGADDEQLE-----------------FPVVYASAINGTSSLSDDPADQEHTMAPI 191
+ +E + LE FPV + SA N + +
Sbjct: 183 DDLLEKYMSGKSLEALELEQEESIRFHNCSLFPVYHGSAKNNIG------------IDNL 230

Query: 192 FDTIIDHIPAPVDNSDEPLQFQVSLLDYNDFVGRIGIGRVFRGTVKVGDQVTLSKLDGTT 251
+ I + + L +V ++Y++ R+ R++ G + + D V +S
Sbjct: 231 IEVITNKFYSSTHRGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLHLRDSVRIS----EK 286

Query: 252 KNFRVTKLFGFFGLERREIQEAKAGDLIAVSGMEDIFVGETITPTDCVEALPILRIDEPT 311
+ ++T+++ E +I +A +G+++ + E + + + T + + P
Sbjct: 287 EKIKITEMYTSINGELCKIDKAYSGEIVILQN-EFLKLNSVLGDTKLLPQRERIENPLPL 345

Query: 312 LQMTFLVNNSPFAGREGKWITSRKVEER--LLAELQT----DVSLRVDPTDSPDKWTVSG 365
LQ T + K ++R LL L D LR + + +S
Sbjct: 346 LQTT---------------VEPSKPQQREMLLDALLEISDSDPLLRYYVDSATHEIILSF 390

Query: 366 RGELHLSILIETMRRE-GYELQVSRPEVIIKEIDGVKCEPFERVQIDTPEEYQGAII 421
G++ + + ++ + E+++ P VI E K E + I+ P A I
Sbjct: 391 LGKVQMEVTCALLQEKYHVEIEIKEPTVIYMERPLKKAE--YTIHIEVPPNPFWASI 445



Score = 42.5 bits (100), Expect = 4e-06
Identities = 18/79 (22%), Positives = 31/79 (39%), Gaps = 1/79 (1%)

Query: 403 EPFERVQIDTPEEYQGAIIQSLSERKGDMLDMQMVGNGQTRLIFLIPARGLIGYSTEFLS 462
EP+ +I P+EY + +++D Q + N + L IPAR + Y ++
Sbjct: 537 EPYLSFKIYAPQEYLSRAYTDAPKYCANIVDTQ-LKNNEVILSGEIPARCIQEYRSDLTF 595

Query: 463 MTRGYGIMNHTFDQYLPVV 481
T G + Y
Sbjct: 596 FTNGRSVCLTELKGYHVTT 614


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1273PF03309320.003 Bvg accessory factor
		>PF03309#Bvg accessory factor

Length = 271

Score = 31.7 bits (72), Expect = 0.003
Identities = 29/126 (23%), Positives = 43/126 (34%), Gaps = 14/126 (11%)

Query: 5 LLGIDLGGTTIKFGILTAAGEVQE---KWAIETNILEGGKHIVPDIIASIKHRLDLYGLS 61
LL ID+ T G+++ +G+ + +W I T + D +A L G
Sbjct: 2 LLAIDVRNTHTVVGLISGSGDHAKVVQQWRIRTE-----PEVTADELALTIDG--LIGDD 54

Query: 62 SADFVGIGMGSPGAVDRDTNTVTGAFNLNWKETQEVGSVVEKELGIPFAIDNDANVAALG 121
+ G S V + V W V GIP +DN V A
Sbjct: 55 AERLTGASGLS--TVPSVLHEVRVMLEQYWPNVPHVLIEPGVRTGIPLLVDNPKEVGA-- 110

Query: 122 ERWVGA 127
+R V
Sbjct: 111 DRIVNC 116


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1275HELNAPAPROT1511e-49 Helicobacter neutrophil-activating protein A family ...
		>HELNAPAPROT#Helicobacter neutrophil-activating protein A family

signature.
Length = 153

Score = 151 bits (383), Expect = 1e-49
Identities = 49/154 (31%), Positives = 85/154 (55%), Gaps = 4/154 (2%)

Query: 19 KKEASKNEKT--KAVLNQAVADLSVAASIVHQVHWYMRGPGFLYLHPKMDELLDSLNANL 76
K E +K +T + LN +++ + S +H+ HWY++GP F LH K +EL D +
Sbjct: 2 KTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFFTLHEKFEELYDHAAETV 61

Query: 77 DEMSERLITIGGAPYSTLAEFSKHSKLDEAKGTYDKTVAQHLARLVEVYLYLSSLYQVGL 136
D ++ERL+ IGG P +T+ E+++H+ + + + + ++ + LV Y +SS + +
Sbjct: 62 DTIAERLLAIGGQPVATVKEYTEHASITDGGN--ETSASEMVQALVNDYKQISSESKFVI 119

Query: 137 DITDEEGDAGTNDLFTAAKTEAEKTIWMLQAERG 170
+ +E D T DLF E EK +WML + G
Sbjct: 120 GLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG 153


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1276PREPILNPTASE290.009 Type IV prepilin cysteine protease (C20) family sig...
		>PREPILNPTASE#Type IV prepilin cysteine protease (C20) family

signature.
Length = 290

Score = 29.4 bits (66), Expect = 0.009
Identities = 42/160 (26%), Positives = 59/160 (36%), Gaps = 25/160 (15%)

Query: 70 SLIIILWASMVHWVSASYCYLLLFSLLFSLF--DWRSQ------EYPFILWLFSFVSLLL 121
+L+ + A + + LLL +L +L D P + F L
Sbjct: 118 ALLSVAVAMTLAPGWGTLAALLLTWVLVALTFIDLDKMLLPDQLTLPLLWGGLLFNLLGG 177

Query: 122 FYSIN---------YLSLILLLLGLLAHLRPFSIGAGDFFYLASLALVLDLTSLIWLIQL 172
F S+ YL L L +G GDF LA+L L +L ++ L
Sbjct: 178 FVSLGDAVIGAMAGYLVLWSLYWAFKLLTGKEGMGYGDFKLLAALGAWLGWQALPIVLLL 237

Query: 173 ASLAGITACLLL-------GIKRIPFIPYLSFGLFWIVLL 205
+SL G + L K IPF PYL+ WI LL
Sbjct: 238 SSLVGAFMGIGLILLRNHHQSKPIPFGPYLAIA-GWIALL 276


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1280HTHTETR337e-04 TetR bacterial regulatory protein HTH signature.
		>HTHTETR#TetR bacterial regulatory protein HTH signature.

Length = 215

Score = 33.4 bits (76), Expect = 7e-04
Identities = 9/34 (26%), Positives = 19/34 (55%)

Query: 8 KLILQGGKAMVTIKQVAEEAGVSRSTVSRYISQK 41
+L Q G + ++ ++A+ AGV+R + + K
Sbjct: 22 RLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDK 55


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1282LPSBIOSNTHSS1532e-50 Lipopolysaccharide core biosynthesis protein signat...
		>LPSBIOSNTHSS#Lipopolysaccharide core biosynthesis protein

signature.
Length = 166

Score = 153 bits (389), Expect = 2e-50
Identities = 58/157 (36%), Positives = 94/157 (59%), Gaps = 2/157 (1%)

Query: 5 IGLYTGSFDPVTNGHLDIVKRASGLFDQIYVGIFDNPTKKSYFKLEVRKAMLTQALADFT 64
+Y GSFDP+T GHLDI++R LFDQ+YV + NP K+ F ++ R + +A+A
Sbjct: 2 NAIYPGSFDPITFGHLDIIERGCRLFDQVYVAVLRNPNKQPMFSVQERLEQIAKAIAHLP 61

Query: 65 NVIVVTSHERLAIDVAKELRVTHLIRGLRNATDFEYEENLEYFNHLLAPNIETVYLISRN 124
N V + E L ++ A++ + ++RGLR +DFE E + N LA ++ETV+L +
Sbjct: 62 NAQVDSF-EGLTVNYARQRQAGAILRGLRVLSDFELELQMANTNKTLASDLETVFLTTST 120

Query: 125 KWQALSSSRVRELIHFQSSLEDLVPQSVIAQV-EKMN 160
++ LSSS V+E+ F ++E VP V A + ++ +
Sbjct: 121 EYSFLSSSLVKEVARFGGNVEHFVPSHVAAALYDQFH 157


34MGAS10270_Spy1290MGAS10270_Spy1296N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy1290-2181.938268Arginine deiminase
MGAS10270_Spy1291-3191.909648Transcription regulator, crp family
MGAS10270_Spy1292-3202.650797Arginine repressor, argR
MGAS10270_Spy1293-3201.879054hypothetical protein
MGAS10270_Spy12940191.044269hypothetical cytosolic protein
MGAS10270_Spy1295-119-1.225539Two-component sensor kinase yesM
MGAS10270_Spy1296019-5.133990Two-component response regulator yesN
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1290ARGDEIMINASE5770.0 Bacterial arginine deiminase signature.
		>ARGDEIMINASE#Bacterial arginine deiminase signature.

Length = 409

Score = 577 bits (1490), Expect = 0.0
Identities = 191/410 (46%), Positives = 276/410 (67%), Gaps = 9/410 (2%)

Query: 5 TPIHVYSEIGKLKKVLLHRPGKEIENLMPDYLERLLFDDIPFLEDAQKEHDAFAQALRDE 64
PI+++SEIG+LKKVLLHRPG+E+ENL P ++ LFDDIP+LE A++EH+ FA L++
Sbjct: 6 NPINIFSEIGRLKKVLLHRPGEELENLTPFIMKNFLFDDIPYLEVARQEHEVFASILKNN 65

Query: 65 GIEVLYLETLAAESLVTP-EIREAFIDEYLSEANIRGRATKKAIRELLMAIEDNQELIEK 123
+E+ Y+E L +E LV+ + FI +++ EA I+ T +++ ++ +I K
Sbjct: 66 LVEIEYIEDLISEVLVSSVALENKFISQFILEAEIKTDFTINLLKDYFSSL-TIDNMISK 124

Query: 124 TMAGVQKSELPEIPASEKGLTDLVESNYPFAIDPMPNLYFTRDPFATIGTGVSLNHMFSE 183
++GV EL +S L DLV F IDPMPN+ FTRDPFA+IG GV++N MF++
Sbjct: 125 MISGVVTEELKNYTSS---LDDLVNGANLFIIDPMPNVLFTRDPFASIGNGVTINKMFTK 181

Query: 184 TRNRETLYGKYIFTHHPIYGGGKVPMVYDRNETTRIEGGDELVLSKDVLAVGISQRTDAA 243
R RET++ +YIF +HP+Y VP+ +R E +EGGDELVL+K +L +GIS+RT+A
Sbjct: 182 VRQRETIFAEYIFKYHPVYKE-NVPIWLNRWEEASLEGGDELVLNKGLLVIGISERTEAK 240

Query: 244 SIEKLLVNIFKQNLGFKKVLAFEFANNRKFMHLDTVFTMVDYDKFTIHPEIEGDLRVYSV 303
S+EKL +++FK F +LAF+ NR +MHLDTVFT +DY FT + +Y +
Sbjct: 241 SVEKLAISLFKNKTSFDTILAFQIPKNRSYMHLDTVFTQIDYSVFTSFTSDDMYFSIYVL 300

Query: 304 TYDNE--ELHIIEEKGDLAELLAANLGVEKVDLIRCGGDNLVAAGREQWNDGSNTLTIAP 361
TY+ ++HI +EK + ++L+ LG K+D+I+C G +L+ REQWNDG+N L IAP
Sbjct: 301 TYNPSSSKIHIKKEKARIKDVLSFYLG-RKIDIIKCAGGDLIHGAREQWNDGANVLAIAP 359

Query: 362 GVVVVYNRNTITNAILESKGLKLIKIHGSELVRGRGGPRCMSMPFEREDI 411
G ++ Y+RN +TN + E G+K+ +I SEL RGRGGPRCMSMP REDI
Sbjct: 360 GEIIAYSRNHVTNKLFEENGIKVHRIPSSELSRGRGGPRCMSMPLIREDI 409


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1292ARGREPRESSOR1242e-39 Bacterial arginine repressor signature.
		>ARGREPRESSOR#Bacterial arginine repressor signature.

Length = 149

Score = 124 bits (314), Expect = 2e-39
Identities = 61/146 (41%), Positives = 92/146 (63%), Gaps = 2/146 (1%)

Query: 1 MNKKETRHQLIRSLISETTIHTQQELQERLQKNGITITQATLSRDMKELNLVKVTSGNDT 60
MNK + RH IR +I+ I TQ EL + L+K+G +TQAT+SRD+KEL+LVKV + N +
Sbjct: 1 MNKGQ-RHIKIREIITANEIETQDELVDILKKDGYNVTQATVSRDIKELHLVKVPTNNGS 59

Query: 61 HYEALAISQTRWEH-RLRFYMEDALVMLKIVQHQIILKTLPGLAQSFGSILDAMQIPEIV 119
+ +L Q +L+ + DA V + H I+LKT+PG AQ+ G+++D + EI+
Sbjct: 60 YKYSLPADQRFNPLSKLKRSLMDAFVKIDSASHLIVLKTMPGNAQAIGALMDNLDWEEIM 119

Query: 120 ATICGDDTCLIVCEDNEQAKACYETL 145
TICGDDT LI+C ++ K + +
Sbjct: 120 GTICGDDTILIICRTHDDTKVVQKKI 145


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1295PF065801812e-54 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 181 bits (462), Expect = 2e-54
Identities = 57/203 (28%), Positives = 100/203 (49%), Gaps = 10/203 (4%)

Query: 362 EKAIGQYRLQALASQINPHFLYNTLDTIIWMAEFNDSKRVVEVTKSLAKYFRLALNQGN- 420
+ +L AL +QINPHF++N L+ I + D + E+ SL++ R +L N
Sbjct: 155 ASMAQEAQLMALKAQINPHFMFNALNNIRALIL-EDPTKAREMLTSLSELMRYSLRYSNA 213

Query: 421 EYIRLADELDHVSQYLFIQKQRYGDKLSYEVQGLDVYADFVIPKLILQPLVENAIYHGIK 480
+ LADEL V YL + ++ D+L +E Q D +P +++Q LVEN I HGI
Sbjct: 214 RQVSLADELTVVDSYLQLASIQFEDRLQFENQINPAIMDVQVPPMLVQTLVENGIKHGIA 273

Query: 481 EVDRKGMIKVTVSDTAQHLVLTVWDNGKGIEDSSLTNSQSLLARGGVGLKNVDQRLKLHY 540
++ + G I + + + L V + G ++ ++ G GL+NV +RL++ Y
Sbjct: 274 QLPQGGKILLKGTKDNGTVTLEVENTGSLALKNTKEST-------GTGLQNVRERLQMLY 326

Query: 541 GKGYHMTIHSQSDHFTEIQLSLP 563
G + + + + + +P
Sbjct: 327 GTEAQIKLSEKQGKVNAM-VLIP 348


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1296HTHFIS935e-24 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 93.4 bits (232), Expect = 5e-24
Identities = 41/165 (24%), Positives = 74/165 (44%), Gaps = 12/165 (7%)

Query: 3 SLLIVEDEYLVRQGIRSLVDFSQFKIDRVNEAENGQLAWDLFQKEPYDIVLTDINMPKLN 62
++L+ +D+ +R + + + + V N W D+V+TD+ MP N
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGY---DVRITSNAATLWRWIAAGDGDLVVTDVVMPDEN 61

Query: 63 GIQLAELIKQESPQTHLVFLTGYDDFNYALSALRLGADDYLLKPFSKADVEDMLGKLRKK 122
L IK+ P ++ ++ + F A+ A GA DYL KPF D+ +++G + +
Sbjct: 62 AFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPF---DLTELIGIIGRA 118

Query: 123 LELSKKTETIQELVEQPQKEVSAIAMAIHE------QLADSDLTL 161
L K+ + E Q + + A+ E +L +DLTL
Sbjct: 119 LAEPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTL 163


35MGAS10270_Spy1304MGAS10270_Spy1313N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy13045263.478297phage-associated cell wall hydrolase
MGAS10270_Spy13055252.414586Holin
MGAS10270_Spy13064262.883227phage protein
MGAS10270_Spy13073262.919512phage protein
MGAS10270_Spy13082213.334624phage protein
MGAS10270_Spy13092213.371594phage infection protein
MGAS10270_Spy13100192.731063Hyaluronoglucosaminidase
MGAS10270_Spy13110202.991015phage endopeptidase
MGAS10270_Spy13121172.439686phage protein
MGAS10270_Spy13131172.855480phage protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1304FLGFLGJ976e-25 Flagellar protein FlgJ signature.
		>FLGFLGJ#Flagellar protein FlgJ signature.

Length = 313

Score = 96.7 bits (240), Expect = 6e-25
Identities = 46/123 (37%), Positives = 65/123 (52%), Gaps = 8/123 (6%)

Query: 23 SLTAAQAILESGWGKHA-------PHNALFGIKADASWTGKSFNTKTQEEYQAGVITDIV 75
L AQA LESGWG+ P LFG+KA +W G T E Y+ G +
Sbjct: 172 HLILAQAALESGWGQRQIRRENGEPSYNLFGVKASGNWKGPVTEITTTE-YENGEAKKVK 230

Query: 76 DRFRAYDSWDESIADHGQFLVDNPRYQSVIGEADYKKACHAIKDAGYATASGYAELLIQI 135
+FR Y S+ E+++D+ L NPRY +V A ++ A++DAGYAT YA L +
Sbjct: 231 AKFRVYSSYLEALSDYVGLLTRNPRYAAVTTAASAEQGAQALQDAGYATDPHYARKLTNM 290

Query: 136 IEE 138
I++
Sbjct: 291 IQQ 293


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1309RTXTOXIND340.003 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 33.6 bits (77), Expect = 0.003
Identities = 27/145 (18%), Positives = 51/145 (35%), Gaps = 21/145 (14%)

Query: 158 RLSSSYQSGINGLKAQLANDKI---GLQAEIQATAQGLSQKYDNELRQLSAKITTTSSGT 214
RL+S + + + Q ++ +AE T +Y+N R +++ SS
Sbjct: 186 RLTSLIKEQFSTWQNQKYQKELNLDKKRAERL-TVLARINRYENLSRVEKSRLDDFSSLL 244

Query: 215 TEAYESKLAGLRAEFTRSNQGMRIELESQISGLRAVQQSTASQISQEIRDRTGAVSRVQQ 274
+ +K A L E E++ + SQ+ Q + A Q
Sbjct: 245 HKQAIAKHAVL-------------EQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQL 291

Query: 275 DLESYQR----RLQDAEDNYSSLTH 295
+ ++ +L+ DN LT
Sbjct: 292 VTQLFKNEILDKLRQTTDNIGLLTL 316


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1310PF072125630.0 Hyaluronoglucosaminidase
		>PF07212#Hyaluronoglucosaminidase

Length = 336

Score = 563 bits (1452), Expect = 0.0
Identities = 336/336 (100%), Positives = 336/336 (100%)

Query: 1 MTETIPLRVQFKRMTAEEWTRSDVILLESEIGFETDTGYAKFGDGKNQFSKLKYLNKPDL 60
MTETIPLRVQFKRMTAEEWTRSDVILLESEIGFETDTGYAKFGDGKNQFSKLKYLNKPDL
Sbjct: 1 MTETIPLRVQFKRMTAEEWTRSDVILLESEIGFETDTGYAKFGDGKNQFSKLKYLNKPDL 60

Query: 61 GAFAQKEETNSKITKLESSKADKNAVYLKAESKIELDKKLNLKGGVMTGQLQFKPNKSGI 120
GAFAQKEETNSKITKLESSKADKNAVYLKAESKIELDKKLNLKGGVMTGQLQFKPNKSGI
Sbjct: 61 GAFAQKEETNSKITKLESSKADKNAVYLKAESKIELDKKLNLKGGVMTGQLQFKPNKSGI 120

Query: 121 KPSSSVGGAINIDMSKSEGAGVVVYSNNDTSDGPLMSLRTGKETFNQSALFVDYSGKTNA 180
KPSSSVGGAINIDMSKSEGAGVVVYSNNDTSDGPLMSLRTGKETFNQSALFVDYSGKTNA
Sbjct: 121 KPSSSVGGAINIDMSKSEGAGVVVYSNNDTSDGPLMSLRTGKETFNQSALFVDYSGKTNA 180

Query: 181 VNIAMRQPTTPNFSSALNITSGNENGSAMQIRGVEKALGTLKITHENPNVEANYDENAAA 240
VNIAMRQPTTPNFSSALNITSGNENGSAMQIRGVEKALGTLKITHENPNVEANYDENAAA
Sbjct: 181 VNIAMRQPTTPNFSSALNITSGNENGSAMQIRGVEKALGTLKITHENPNVEANYDENAAA 240

Query: 241 LSIDIVKKQKGGKGTAAQGIYINSTSGTTGKLLRIRNLGDDKFYVKHDGGFYAKKTSQID 300
LSIDIVKKQKGGKGTAAQGIYINSTSGTTGKLLRIRNLGDDKFYVKHDGGFYAKKTSQID
Sbjct: 241 LSIDIVKKQKGGKGTAAQGIYINSTSGTTGKLLRIRNLGDDKFYVKHDGGFYAKKTSQID 300

Query: 301 GNLKLKNPTADDHAATKAYVDSEVKKLKALLMDKQV 336
GNLKLKNPTADDHAATKAYVDSEVKKLKALLMDKQV
Sbjct: 301 GNLKLKNPTADDHAATKAYVDSEVKKLKALLMDKQV 336


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1311SSPAMPROTEIN290.036 Salmonella surface presentation of antigen gene typ...
		>SSPAMPROTEIN#Salmonella surface presentation of antigen gene type M

signature.
Length = 147

Score = 28.9 bits (64), Expect = 0.036
Identities = 23/65 (35%), Positives = 29/65 (44%), Gaps = 6/65 (9%)

Query: 387 ERINALENNQKVITNNQKQFELNLPKYLNDINGKRVWYEKPDDNIEHKIGDYWFEKNGKY 446
E I AL Q ++ K EL + + I KR EK + + K YW K G Y
Sbjct: 66 EEIYALLRKQSIVRRQIKDLELQIIQ----IQEKRSELEKKREEFQEK-SKYWLRKEGNY 120

Query: 447 QRTWI 451
QR WI
Sbjct: 121 QR-WI 124


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1313GPOSANCHOR482e-07 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 47.8 bits (113), Expect = 2e-07
Identities = 36/205 (17%), Positives = 69/205 (33%), Gaps = 17/205 (8%)

Query: 461 LTKESDETKKLKKEQEGLVESNKQLRDSVREGVQERKKGLESVKESTAAHQKLADEIIKL 520
T +S + K L+ E+ L L + + + +A + L E L
Sbjct: 136 STADSAKIKTLEAEKAALAARKADLE-------KALEGAMNFSTADSAKIKTLEAEKAAL 188

Query: 521 AAKENKTAGEKRNLKNKIDELNGSIDGLNLAYDKNSNSLSHNADQIKSRISAMEAESTWQ 580
A++ + N + I L + + ++ + S
Sbjct: 189 EARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKA----DLEKALEGAMNFS--- 241

Query: 581 TAQQNLLNIEQKRSEVSKKLAENAELRKKWNEEANVSDSVRKEKIAELTEEEAKLKNMQT 640
+ I+ +E + A AEL K E A + KI L E+A L+ +
Sbjct: 242 --TADSAKIKTLEAEKAALEARQAELEKA-LEGAMNFSTADSAKIKTLEAEKAALEAEKA 298

Query: 641 QLQEEYNKTSATQQAAADAMAAAEE 665
L+ + +A +Q+ + A+ E
Sbjct: 299 DLEHQSQVLNANRQSLRRDLDASRE 323



Score = 30.8 bits (69), Expect = 0.036
Identities = 43/240 (17%), Positives = 77/240 (32%), Gaps = 33/240 (13%)

Query: 461 LTKESDETKKLKKEQEGLVESNKQLRDSVREGVQERKKGLESVKESTAAHQKLADEIIKL 520
T +S + K L+ E+ L L ++ + +K A L +L
Sbjct: 206 STADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAEL 265

Query: 521 AAKENKTAGEKRNLKNKIDELNGSIDGL----------NLAYDKNSNSLSHNADQIKSRI 570
KI L L + + N SL + D +
Sbjct: 266 EKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAK 325

Query: 571 SAMEAESTWQTAQQNLLNIEQKRSEVSKKLAENAELRK-------KWNEEANVSDSVR-- 621
+EAE Q ++ E R + + L + E +K K E+ +S++ R
Sbjct: 326 KQLEAEH--QKLEEQNKISEASRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQS 383

Query: 622 -----------KEKI-AELTEEEAKLKNMQTQLQEEYNKTSATQQAAADAMAAAEESGSA 669
K+++ L E +KL ++ +E T++ A+ A E A
Sbjct: 384 LRRDLDASREAKKQVEKALEEANSKLAALEKLNKELEESKKLTEKEKAELQAKLEAEAKA 443


36MGAS10270_Spy1595MGAS10270_Spy1602N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy1595-110-0.923267Ferrichrome transport system permease protein
MGAS10270_Spy1596-211-1.358309Ferrichrome-binding protein
MGAS10270_Spy1597-29-0.783606hypothetical protein
MGAS10270_Spy1598-210-0.589094Putative Fe3+-siderophore transport protein
MGAS10270_Spy1599-1120.962749Immunogenic secreted protein
MGAS10270_Spy16000110.975198Alanine racemase
MGAS10270_Spy16011121.821121holo-synthase
MGAS10270_Spy1602-290.955361Protein translocase subunit secA
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1595TYPE3IMSPROT290.040 Type III secretion system inner membrane S protein ...
		>TYPE3IMSPROT#Type III secretion system inner membrane S protein

family signature.
Length = 354

Score = 28.6 bits (64), Expect = 0.040
Identities = 19/76 (25%), Positives = 32/76 (42%), Gaps = 5/76 (6%)

Query: 264 LASVATSIVGVVSFLGL---IVPHMSRLLVGSKHQILIPFSALLGAFVFLLADTLGRSLA 320
+ S A + +GL H S+L++ Q +PFS L V + L
Sbjct: 29 VVSTALIVALSAMLMGLSDYYFEHFSKLMLIPAEQSYLPFSQALSYVVDNVLLEFF-YLC 87

Query: 321 YPLEISPAIIMSIVGG 336
+PL ++ A +M+I
Sbjct: 88 FPL-LTVAALMAIASH 102


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1596FERRIBNDNGPP708e-16 Ferrichrome-binding periplasmic protein signature.
		>FERRIBNDNGPP#Ferrichrome-binding periplasmic protein signature.

Length = 296

Score = 69.6 bits (170), Expect = 8e-16
Identities = 54/265 (20%), Positives = 103/265 (38%), Gaps = 24/265 (9%)

Query: 29 VACVNQHPKTAKETEQQRIVATSVAVVDICDRLNLDLVGVCDSKLYTL----PKRYDAVK 84
+ A + RIVA V++ L + GV D+ Y L P D+V
Sbjct: 20 PLLWQMNTAHAAAIDPNRIVALEWLPVELLLALGIVPYGVADTINYRLWVSEPPLPDSVI 79

Query: 85 RVGLPMNPDIELIASLKPTWILSPNSLQEDLEPKYQKLDTEYGFLNLRSVEG------MY 138
VGL P++EL+ +KP++++ P + L +G
Sbjct: 80 DVGLRTEPNLELLTEMKPSFMV----WSAGYGPSPEMLARIAPGRGFNFSDGKQPLAMAR 135

Query: 139 QSIDDLGNLFQRQQEAKELRQQYQDYYRAFQAKRKGK-KKPKVLILMGLPGSYLVATNQS 197
+S+ ++ +L Q A+ QY+D+ R+ + + + +P +L + P LV S
Sbjct: 136 KSLTEMADLLNLQSAAETHLAQYEDFIRSMKPRFVKRGARPLLLTTLIDPRHMLVFGPNS 195

Query: 198 YVGNLLDLAGGENVYQ--SDEKEFLSVNPEDMLA-KEPDLILRTAHAIPDKVKVLFDKEF 254
+LD G N +Q ++ +V+ + + A K+ D++ D +
Sbjct: 196 LFQEILDEYGIPNAWQGETNFWGSTAVSIDRLAAYKDVDVLCFDHDNSKDMDAL------ 249

Query: 255 AENDIWKHFTAVKEGKVYDLDNTLF 279
+W+ V+ G+ + F
Sbjct: 250 MATPLWQAMPFVRAGRFQRVPAVWF 274


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1600ALARACEMASE347e-121 Alanine racemase signature.
		>ALARACEMASE#Alanine racemase signature.

Length = 356

Score = 347 bits (891), Expect = e-121
Identities = 121/368 (32%), Positives = 194/368 (52%), Gaps = 23/368 (6%)

Query: 7 RPTVARVNLQAIKENVASVQKHIPLGVKTYAVVKADAYGHGAVQVSKALLPQVDGYCVSN 66
RP A ++LQA+K+N++ V++ + ++VVKA+AYGHG ++ A+ DG+ + N
Sbjct: 3 RPIQASLDLQALKQNLSIVRQAAT-HARVWSVVKANAYGHGIERIWSAI-GATDGFALLN 60

Query: 67 LDEALQLRQAGIDKEILIL-GVLLPNELELAVANAITVTIAS---LDWIALARLEKKECQ 122
L+EA+ LR+ G IL+L G +LE+ + +T + S L + ARL+
Sbjct: 61 LEEAITLRERGWKGPILMLEGFFHAQDLEIYDQHRLTTCVHSNWQLKALQNARLKAP--- 117

Query: 123 GLKVHVKVDSGMGRIGLRSSKEVNLLIDSLKELGADVEGIFTHFATADEADDTKFNQQLQ 182
L +++KV+SGM R+G + + + + + +HFA A+ D +
Sbjct: 118 -LDIYLKVNSGMNRLGFQPDRVLTVWQQLRAMANVGEMTLMSHFAEAEHPDGIS--GAMA 174

Query: 183 FFKKLIAGLEDKPRLVHASNSATSIWHSDTIFNAVRLGIVSYGLNPSGSN-LSLPFPLQE 241
++ GL SNSA ++WH + F+ VR GI+ YG +PSG L+
Sbjct: 175 RIEQAAEGL---ECRRSLSNSAATLWHPEAHFDWVRPGIILYGASPSGQWRDIANTGLRP 231

Query: 242 ALSLESSLVHVKMISAGDTVGYGATYTAKKSEYVGTVPIGYADGWTRNM-QGFSVLVDGQ 300
++L S ++ V+ + AG+ VGYG YTA+ + +G V GYADG+ R+ G VLVDG
Sbjct: 232 VMTLSSEIIGVQTLKAGERVGYGGRYTARDEQRIGIVAAGYADGYPRHAPTGTPVLVDGV 291

Query: 301 FCEIIGRVSMDQLTIRLSKA--YPLGTKVTLIGSNQQKNISTTDIANYRNTINYEVLCLL 358
+G VSMD L + L+ +GT V L G K I D+A T+ YE++C L
Sbjct: 292 RTMTVGTVSMDMLAVDLTPCPQAGIGTPVELWG----KEIKIDDVAAAAGTVGYELMCAL 347

Query: 359 SDRIPRIY 366
+ R+P +
Sbjct: 348 ALRVPVVT 355


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1602SECA10520.0 SecA protein signature.
		>SECA#SecA protein signature.

Length = 901

Score = 1052 bits (2723), Expect = 0.0
Identities = 394/903 (43%), Positives = 560/903 (62%), Gaps = 73/903 (8%)

Query: 1 MANILRKVIENDKG-ELRKLEKIAKKVESYADQMASLSDRDLQGKTLEFKERYQKGETLE 59
+ +L KV + LR++ K+ + + +M LSD +L+GKT EF+ R +KGE LE
Sbjct: 2 LIKLLTKVFGSRNDRTLRRMRKVVNIINAMEPEMEKLSDEELKGKTAEFRARLEKGEVLE 61

Query: 60 QLLPEAFAVVREAAKRVLGLFPYRVQIMGGIVLHNGDVPEMRTGEGKTLTATMPVYLNAI 119
L+PEAFAVVREA+KRV G+ + VQ++GG+VL+ + EMRTGEGKTLTAT+P YLNA+
Sbjct: 62 NLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNERCIAEMRTGEGKTLTATLPAYLNAL 121

Query: 120 AGEGVHVITVNEYLSTRDATEMGEVYSWLGLSVGINLAAKSPAEKREAYNCDITYSTNSE 179
G+GVHV+TVN+YL+ RDA ++ +LGL+VGINL KREAY DITY TN+E
Sbjct: 122 TGKGVHVVTVNDYLAQRDAENNRPLFEFLGLTVGINLPGMPAPAKREAYAADITYGTNNE 181

Query: 180 VGFDYLRDNMVVRQEDMVQRPLNFALVDEVDSVLIDEARTPLIVSGAVSSETNQLYIRAD 239
GFDYLRDNM E+ VQR L++ALVDEVDS+LIDEARTPLI+SG + ++Y R +
Sbjct: 182 YGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSS-EMYKRVN 240

Query: 240 MFVKTLT------------SVDYVIDVPTKTIGLSDSGIDKAESYFNLS-------NLYD 280
+ L + +D ++ + L++ G+ E +LY
Sbjct: 241 KIIPHLIRQEKEDSETFQGEGHFSVDEKSRQVNLTERGLVLIEELLVKEGIMDEGESLYS 300

Query: 281 IENVALTHFIDNALRANYIMLLDIDYVVSEDGEILIVDQFTGRTMEGRRFSDGLHQAIEA 340
N+ L H + ALRA+ + D+DY+V +DGE++IVD+ TGRTM+GRR+SDGLHQA+EA
Sbjct: 301 PANIMLMHHVTAALRAHALFTRDVDYIV-KDGEVIIVDEHTGRTMQGRRWSDGLHQAVEA 359

Query: 341 KEGVRIQEESKTSASITYQNMFRMYKKLAGMTGTAKTEEEEFREVYNMRIIPIPTNRPIA 400
KEGV+IQ E++T ASIT+QN FR+Y+KLAGMTGTA TE EF +Y + + +PTNRP+
Sbjct: 360 KEGVQIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMI 419

Query: 401 RIDHTDLLYPTLESKFRAVVEDVKTRHAKGQPILVGTVAVETSDLISRKLVEAGIPHEVL 460
R D DL+Y T K +A++ED+K R AKGQP+LVGT+++E S+L+S +L +AGI H VL
Sbjct: 420 RKDLPDLVYMTEAEKIQAIIEDIKERTAKGQPVLVGTISIEKSELVSNELTKAGIKHNVL 479

Query: 461 NAKNHFKEAQIIMNAGQRGAVTIATNMAGRGTDIKLG----------------------- 497
NAK H EA I+ AG AVTIATNMAGRGTDI LG
Sbjct: 480 NAKFHANEAAIVAQAGYPAAVTIATNMAGRGTDIVLGGSWQAEVAALENPTAEQIEKIKA 539

Query: 498 ------EGVRELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMRRFG 551
+ V E GGL +IGTERHESRRIDNQLRGRSGRQGD G S+FYLS+ED LMR F
Sbjct: 540 DWQVRHDAVLEAGGLHIIGTERHESRRIDNQLRGRSGRQGDAGSSRFYLSMEDALMRIFA 599

Query: 552 SDRIKAFLDRMKLDEEDTVIKSGMLGRQVESAQKRVEGNNYDTRKQVLQYDDVMREQREI 611
SDR+ + ++ + + I+ + + + +AQ++VE N+D RKQ+L+YDDV +QR
Sbjct: 600 SDRVSGMMRKLGM-KPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRA 658

Query: 612 IYANRRDVITANRDLGPEIKAMIKRTIDRAVDAHARSNR---KDAIDAIVTFARTSLVPE 668
IY+ R +++ + D+ I ++ + +DA+ I + + +
Sbjct: 659 IYSQRNELLDVS-DVSETINSIREDVFKATIDAYIPPQSLEEMWDIPGLQERLKNDFDLD 717

Query: 669 ESIS--AKELRGLKDDQIKEKLYQRALAIYDQQLSKLRDQEAIIEFQKVLILMIVDNKWT 726
I+ + L ++ ++E++ +++ +Y ++ + E + F+K ++L +D+ W
Sbjct: 718 LPIAEWLDKEPELHEETLRERILAQSIEVYQRKEEVVG-AEMMRHFEKGVMLQTLDSLWK 776

Query: 727 EHIDALDQLRNAVGLRGYAQNNPVVEYQAEGFKMFQDMIGAIEFDVTRTMMKAQIH-EQE 785
EH+ A+D LR + LRGYAQ +P EY+ E F MF M+ +++++V T+ K Q+ +E
Sbjct: 777 EHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFSMFAAMLESLKYEVISTLSKVQVRMPEE 836

Query: 786 RERASQRATTAAPQNIQSQQSANTDD-------------LPKVERNEACPCGSGKKFKNC 832
E Q+ A + Q QQ ++ DD KV RN+ CPCGSGKK+K C
Sbjct: 837 VEELEQQRRMEAERLAQMQQLSHQDDDSAAAAALAAQTGERKVGRNDPCPCGSGKKYKQC 896

Query: 833 HGR 835
HGR
Sbjct: 897 HGR 899


37MGAS10270_Spy1747MGAS10270_Spy1756N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy1747-2144.641648Collagen-like surface protein
MGAS10270_Spy1749-2163.805270Pullulanase
MGAS10270_Spy1748-2193.709430hypothetical protein
MGAS10270_Spy1750-1214.275025Glucan 1,6-alpha-glucosidase
MGAS10270_Spy1751-2195.153041Multiple sugar transport ATP-binding protein
MGAS10270_Spy1752-2225.479233Leucine rich protein
MGAS10270_Spy1753-3215.210083Streptokinase
MGAS10270_Spy1754-2205.861863D-tyrosyl-tRNA(Tyr) deacylase
MGAS10270_Spy1755-1205.912222GTP pyrophosphokinase /
MGAS10270_Spy17560206.124082Collagen-like surface protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1747GPOSANCHOR651e-13 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 64.7 bits (157), Expect = 1e-13
Identities = 37/87 (42%), Positives = 44/87 (50%), Gaps = 1/87 (1%)

Query: 224 ETPEQPGEKAPEKSKEVTPAPEKPADKEANQTPE-RRNGNMAKTPVANNHRRLPATGEQA 282
E + S+ P A Q P+ N K P+ R+LP+TGE A
Sbjct: 453 EELAKLRAGKASDSQTPDAKPGNKAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETA 512

Query: 283 NPFFTAAAVAVMTTAGVLAVTKRKENN 309
NPFFTAAA+ VM TAGV AV KRKE N
Sbjct: 513 NPFFTAAALTVMATAGVAAVVKRKEEN 539


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1751PF05272356e-04 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 34.7 bits (79), Expect = 6e-04
Identities = 14/56 (25%), Positives = 20/56 (35%), Gaps = 9/56 (16%)

Query: 34 IVFVGPSGCGKSTTLRMIAGLEDISEGELKIGGEVVNDKSPKDRDIAMVFQNYALY 89
+V G G GKST + + GL+ S+ IG +D Y
Sbjct: 599 VVLEGTGGIGKSTLINTLVGLDFFSDTHFDIG---------TGKDSYEQIAGIVAY 645


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1752HTHFIS347e-04 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 34.0 bits (78), Expect = 7e-04
Identities = 10/30 (33%), Positives = 19/30 (63%)

Query: 243 ALWSEHGNLVQTAQRLYIHRNSLQYKLDKF 272
AL + GN ++ A L ++RN+L+ K+ +
Sbjct: 444 ALTATRGNQIKAADLLGLNRNTLRKKIREL 473


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1753STREPKINASE7670.0 Streptococcus streptokinase protein signature.
		>STREPKINASE#Streptococcus streptokinase protein signature.

Length = 440

Score = 767 bits (1982), Expect = 0.0
Identities = 374/440 (85%), Positives = 391/440 (88%), Gaps = 8/440 (1%)

Query: 1 MKNYLSFGMFALLFALTFGTVKPVQAIAGPEWLLDRPSVNNSQLVVSVAGTVEGTNQEIS 60
MKNYLSFGMFALLFALTFGTV VQAIAGPEWLLDRPSVNNSQLVVSVAGTVEGTNQ+IS
Sbjct: 1 MKNYLSFGMFALLFALTFGTVNSVQAIAGPEWLLDRPSVNNSQLVVSVAGTVEGTNQDIS 60

Query: 61 LKFFEIDLTSRPAQGGKTEPGLRPKSK--------MPYKLEKADLLKAIQEQLIANVHSN 112
LKFFEIDLTSRPA GGKTE GL PKSK M +KLEKADLLKAIQEQLIANVHSN
Sbjct: 61 LKFFEIDLTSRPAHGGKTEQGLSPKSKPFATDSGAMSHKLEKADLLKAIQEQLIANVHSN 120

Query: 113 DGYFEVIDFASDATITDRNGKVYFADRDDSVTLPTQPVQEFLLSGHVRVRPYRPKAVHNS 172
D YFEVIDFASDATITDRNGKVYFAD+D SVTLPTQPVQEFLLSGHVRVRPY+ K + N
Sbjct: 121 DDYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLSGHVRVRPYKEKPIQNQ 180

Query: 173 AERVNVNYEVSFVSETGDLDFTPSLRDRYHLTTLAVGDSLSSQELAAIAQFILSKEHPDY 232
A+ V+V Y V F D DF P L+D L TLA+GD+++SQEL A AQ IL+K HP Y
Sbjct: 181 AKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKNHPGY 240

Query: 233 IITKRDSSIVTHDNDIFRTILPMDQEFTYHVKDREQAYGINKKSGQKEKINNTDLISEKY 292
I +RDSSIVTHDNDIFRTILPMDQEFTY VK+REQAY INKKSG E+INNTDLISEKY
Sbjct: 241 TIYERDSSIVTHDNDIFRTILPMDQEFTYRVKNREQAYRINKKSGLNEEINNTDLISEKY 300

Query: 293 YVLKKGEKPYDPFDRSHLKLFTINYVDVDTNKLLKSEQLLTASERNLDFRDLYDPRDKAK 352
YVLKKGEKPYDPFDRSHLKLFTI YVDVDTN+LLKSEQLLTASERNLDFRDLYDPRDKAK
Sbjct: 301 YVLKKGEKPYDPFDRSHLKLFTIKYVDVDTNELLKSEQLLTASERNLDFRDLYDPRDKAK 360

Query: 353 LLYNNLDAFGIMDYTLTGKVEDNHDDTNRIITVYMGKRPEGENASYHLAYDKDRYTEEER 412
LLYNNLDAFGIMDYTLTGKVEDNHDDTNRIITVYMGKRPEGENASYHLAYDKDRYTEEER
Sbjct: 361 LLYNNLDAFGIMDYTLTGKVEDNHDDTNRIITVYMGKRPEGENASYHLAYDKDRYTEEER 420

Query: 413 EVYSYLRYTGTPIPDNPKDK 432
EVYSYLRYTGTPIPDNP DK
Sbjct: 421 EVYSYLRYTGTPIPDNPNDK 440


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1756GPOSANCHOR644e-13 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 63.5 bits (154), Expect = 4e-13
Identities = 43/130 (33%), Positives = 56/130 (43%), Gaps = 3/130 (2%)

Query: 254 EAGKPGEKAPEKSPEVTPTPETPEQP---GEKAPEKSPEVTPTPEMPEQPGEKAPEKSKE 310
A + K E+S ++T + Q E K E+ + KA +
Sbjct: 410 AALEKLNKELEESKKLTEKEKAELQAKLEAEAKALKEKLAKQAEELAKLRAGKASDSQTP 469

Query: 311 VTPAPEKPADKEANQTPERRNGNMAKTPVANNHRRLPATGEQANPFFTAAAVAVMTTAGV 370
K + N K P+ R+LP+TGE ANPFFTAAA+ VM TAGV
Sbjct: 470 DAKPGNKAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETANPFFTAAALTVMATAGV 529

Query: 371 LAVTKRKENN 380
AV KRKE N
Sbjct: 530 AAVVKRKEEN 539


38MGAS10270_Spy1776MGAS10270_Spy1803N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10270_Spy17761121.713456Dipeptide transport ATP-binding protein dppD
MGAS10270_Spy17771112.331265Dipeptide transport ATP-binding protein dppF
MGAS10270_Spy17782122.115744hypothetical protein
MGAS10270_Spy17793131.958853Streptococcal histidine triad protein
MGAS10270_Spy17807171.887192Laminin-binding surface protein
MGAS10270_Spy17816181.226258Fibronectin-binding protein
MGAS10270_Spy17826180.512706C5A peptidase precursor
MGAS10270_Spy17831020-0.964100M protein
MGAS10270_Spy17845210.829185M protein
MGAS10270_Spy17852210.699980M protein
MGAS10270_Spy17861220.516363trans-acting positive regulator Mry
MGAS10270_Spy17870231.043670hypothetical protein
MGAS10270_Spy1788-1221.232462Immunogenic protein
MGAS10270_Spy1789-1221.177471Immunogenic secreted protein
MGAS10270_Spy1790-122-0.493054two-component system histidine kinase
MGAS10270_Spy1791-222-0.248258Two-component response regulator
MGAS10270_Spy1792-2232.025790ABC transporter permease protein
MGAS10270_Spy17931151.904802ABC transporter ATP-binding protein
MGAS10270_Spy17941152.336994periplasmic component of efflux system
MGAS10270_Spy17951182.735778hypothetical protein
MGAS10270_Spy17962203.161678hypothetical protein
MGAS10270_Spy17972203.194594Fibronectin-binding protein
MGAS10270_Spy17982181.609437Fibronectin-binding protein
MGAS10270_Spy17992322.586282hypothetical cytosolic protein
MGAS10270_Spy18002341.245766Peptidyl-prolyl cis-trans isomerase
MGAS10270_Spy1801021-1.769994hypothetical protein
MGAS10270_Spy1802021-1.163224Streptopain precursor
MGAS10270_Spy1803020-1.648443Streptopain precursor
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1776HTHFIS290.024 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 28.6 bits (64), Expect = 0.024
Identities = 9/16 (56%), Positives = 12/16 (75%)

Query: 45 IIGASGSGKSLLAHAI 60
I G SG+GK L+A A+
Sbjct: 165 ITGESGTGKELVARAL 180


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1779PF05616340.003 Neisseria meningitidis TspB protein
		>PF05616#Neisseria meningitidis TspB protein

Length = 501

Score = 34.0 bits (77), Expect = 0.003
Identities = 24/87 (27%), Positives = 35/87 (40%), Gaps = 2/87 (2%)

Query: 226 IPKKDLSPSELAAAQAYWSQKQGRGARPSDY-RPTPAPGRRKAPIPDVTPNPGRGHQPD- 283
IP+ DL+P A A + P++ P PG R P PD NP D
Sbjct: 310 IPRPDLTPGSAEAPNAQPLPEVSPAENPANNPAPNENPGTRPNPEPDPDLNPDANPDTDG 369

Query: 284 NGGYHPAPPRPNDASQNKHQRDEFKGK 310
G P P D +H+++ +G+
Sbjct: 370 QPGTRPDSPAVPDRPNGRHRKERKEGE 396


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1780ADHESNFAMILY2475e-83 Adhesin family signature.
		>ADHESNFAMILY#Adhesin family signature.

Length = 309

Score = 247 bits (631), Expect = 5e-83
Identities = 82/323 (25%), Positives = 143/323 (44%), Gaps = 34/323 (10%)

Query: 1 MKKGFFLMAMVVSLVMIAGCDKSANPKQPTQGMSVVTSFYPMYAMTKEVSGDLNDVR-MI 59
MKK L+ + +S +++ C Q + VV + + +TK ++GD D+ ++
Sbjct: 1 MKKLGTLLVLFLSAIILVACASGKKDTTSGQKLKVVATNSIIADITKNIAGDKIDLHSIV 60

Query: 60 QSGAGIHSFEPSVNDVAAIYDADLFVYHSHTLE----AWARDLDPNLKKSKVDVFEASKP 115
G H +EP DV +ADL Y+ LE AW L N KK++ + A
Sbjct: 61 PIGQDPHEYEPLPEDVKKTSEADLIFYNGINLETGGNAWFTKLVENAKKTENKDYFA--- 117

Query: 116 LTLDRVKGLEDMEVTQGIDPATLY--------DPHTWTDPVLAGEEAVNIAKELGRLDPK 167
V+ G+D L DPH W + A NIAK+L DP
Sbjct: 118 -------------VSDGVDVIYLEGQNEKGKEDPHAWLNLENGIIFAKNIAKQLSAKDPN 164

Query: 168 HKDSYTKKAKAFKKEAEQLTEEYTQKFKKVR--SKTFVTQHTAFSYLAKRFGLKQLGISG 225
+K+ Y K K + + ++L +E KF K+ K VT AF Y +K +G+ I
Sbjct: 165 NKEFYEKNLKEYTDKLDKLDKESKDKFNKIPAEKKLIVTSEGAFKYFSKAYGVPSAYIWE 224

Query: 226 ISPEQEPSPRQLKEIQDFVKEYNVKTIFAEDNVNPKIAHAIAKSTGAKVKT---LSPLEA 282
I+ E+E +P Q+K + + +++ V ++F E +V+ + +++ T + +
Sbjct: 225 INTEEEGTPEQIKTLVEKLRQTKVPSLFVESSVDDRPMKTVSQDTNIPIYAQIFTDSIAE 284

Query: 283 APSGNKTYLENLRANLEVLYQQL 305
+Y ++ NL+ + + L
Sbjct: 285 QGKEGDSYYSMMKYNLDKIAEGL 307


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1781IGASERPTASE531e-09 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 53.1 bits (127), Expect = 1e-09
Identities = 52/331 (15%), Positives = 99/331 (29%), Gaps = 30/331 (9%)

Query: 2 QSISSTQGNTANTSQKWYDINEHGIIPVDISLETAKEDFKKEVEKSRLSKEQQKTYNQKI 61
Q++ +T T N Q +P S + +T
Sbjct: 990 QTVDTTNITTPNNIQA--------DVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVA 1041

Query: 62 EAAKNKDDLLLTYHREYSEDIKKHSASTEPTTQPVEAPVQETQASASDSMVTDDSTSVTT 121
E +K + + ++ +E ++ + V+A Q + + S S + T+ T
Sbjct: 1042 ENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETK 1101

Query: 122 DSPKESP----------VAPASSPESEKSSVAASSEETSSPETPAAPEAPALSEAPVQPA 171
++ S+ S SE PA P ++ Q
Sbjct: 1102 ETATVEKEEKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQ 1161

Query: 172 ESEEPSVAAPSEETPSPAAPE-----TPEEPAAPAPSPESEEPSVAASSEETPSPAAPAL 226
+ P++ET S T + +PE+ P+ + + S P
Sbjct: 1162 TNTTADTEQPAKETSSNVEQPVTESTTVNTGNSVVENPENTTPATTQPTVNSESSNKPKN 1221

Query: 227 SEAPAQPAESEKPSVAASSEETPSPSTPAESETQTPPAVTKDSDKPSSAAEKPAASSLVS 286
+ + A +S S + + AV S A K +L
Sbjct: 1222 RHRRSVRSVPHNVEPATTSSNDRSTVALCDLTSTNTNAVL------SDARAKAQFVALNV 1275

Query: 287 EQTVQQPTSKRSSDKKEEQEQSYSPNRSLSR 317
+ V Q S+ + E Q + N S+++
Sbjct: 1276 GKAVSQHISQLEMN-NEGQYNVWVSNTSMNK 1305



Score = 52.0 bits (124), Expect = 2e-09
Identities = 41/248 (16%), Positives = 73/248 (29%), Gaps = 24/248 (9%)

Query: 85 HSASTEPTTQPVEAPVQETQASASDSMVTDDSTSVTTDSPKESPVAPASSP--------- 135
++ E Q V+ T + + + S + E+PV P +
Sbjct: 981 YNPEVEKRNQTVDTTNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETV 1040

Query: 136 -ESEKSSVAASSEETSSPETPAAPEAPALSEA----PVQPAESEEPSVAAPSEETPSPAA 190
E+ K + A EA +E + ++ET +
Sbjct: 1041 AENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTET 1100

Query: 191 PETP----EEPAAPAPSPESEEPSVAASSEETPSPAAPALSEAPAQPAESEKPSVAASSE 246
ET EE A E P V S+ +P + A+PA P+V
Sbjct: 1101 KETATVEKEEKAKVETEKTQEVPKVT--SQVSPKQEQSETVQPQAEPARENDPTVNIKEP 1158

Query: 247 ETPSPSTPAESE--TQTPPAVTK--DSDKPSSAAEKPAASSLVSEQTVQQPTSKRSSDKK 302
++ + +T + +T V + + + + QPT S K
Sbjct: 1159 QSQTNTTADTEQPAKETSSNVEQPVTESTTVNTGNSVVENPENTTPATTQPTVNSESSNK 1218

Query: 303 EEQEQSYS 310
+ S
Sbjct: 1219 PKNRHRRS 1226



Score = 42.7 bits (100), Expect = 2e-06
Identities = 37/204 (18%), Positives = 68/204 (33%), Gaps = 17/204 (8%)

Query: 125 KESPVAPASSPESEKSSVAASSEETSSPETPAAPEAPALSEAPVQPAESEE------PSV 178
+ V + S +++ E EAP AP P+E+ E
Sbjct: 988 RNQTVDTTNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVAENSKQE 1047

Query: 179 AAPSEETPSPAAPETPE-----EPAAPAPSPESEEPSVAASSEETPSPAAPALSEAPAQP 233
+ E+ A T + + A ++ VA S ET E
Sbjct: 1048 SKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETKETATVE 1107

Query: 234 AESEKPSVAASSEETPS-----PSTPAESETQTPPAVTKDSDKPSSAAEKPAASSLVSEQ 288
E + ++E P +SET P A + P+ ++P + + +
Sbjct: 1108 KEEKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQT-NTTA 1166

Query: 289 TVQQPTSKRSSDKKEEQEQSYSPN 312
+QP + SS+ ++ +S + N
Sbjct: 1167 DTEQPAKETSSNVEQPVTESTTVN 1190


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1782SUBTILISIN1066e-27 Subtilisin serine protease family (S8) signature.
		>SUBTILISIN#Subtilisin serine protease family (S8) signature.

Length = 326

Score = 106 bits (266), Expect = 6e-27
Identities = 49/226 (21%), Positives = 84/226 (37%), Gaps = 47/226 (20%)

Query: 117 KAGKGAGTVVAVIDAGFDKNHEAWRLTDKAKARYQSKEDLEKAKKEHGITYGEWVNDKVA 176
+G G VAV+D G D +H DL KA+ G + +
Sbjct: 36 NQTRGRGVKVAVLDTGCDADH----------------PDL-KARIIGGRNFTDDDEGDPE 78

Query: 177 YYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLA 236
+ DY+ HGTHV+G ++ + G PEA LL+++V G
Sbjct: 79 IFKDYNG---------HGTHVAGTIAATENE-----NGVVGVAPEADLLIIKVLNKQGSG 124

Query: 237 DYARNYAQAIRDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGND 296
Y Q I A+ +I+MS G E +A A + + ++ +AGN+
Sbjct: 125 QYD-WIIQGIYYAIEQKVDIISMSLGGPE-----DVPELHEAVKKAVASQILVMCAAGNE 178

Query: 297 SSFGGKPRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETAT 342
+ +G P + ++V + + D+ +E +
Sbjct: 179 GDGDDR----------TDELGYPGCYNEVISVGAINFDRHASEFSN 214



Score = 79.9 bits (197), Expect = 5e-18
Identities = 37/139 (26%), Positives = 58/139 (41%), Gaps = 22/139 (15%)

Query: 457 NATPKVLPTASGTK---LSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSM 513
+V+ + S FS+ + D+ APG+DILS+V KYA SGTSM
Sbjct: 192 GCYNEVISVGAINFDRHASEFSNSNN------EVDLVAPGEDILSTVPGGKYATFSGTSM 245

Query: 514 SAPLVAGIMGL-LQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGA 572
+ P VAG + L Q + D+T E L+ L + SP+ +G
Sbjct: 246 ATPHVAGALALIKQLANASFERDLTEPE----LYAQLIKRTIPLGN-------SPKMEGN 294

Query: 573 GAVDAKKASA-ATMYVTDK 590
G + + ++ T +
Sbjct: 295 GLLYLTAVEELSRIFDTQR 313


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1783GPOSANCHOR1169e-31 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 116 bits (291), Expect = 9e-31
Identities = 157/384 (40%), Positives = 210/384 (54%), Gaps = 38/384 (9%)

Query: 5 QTKKNYSLRKLKTGTASVAVALTVLGAGFANQTEVRADEAKKMEVKESEKESQYKTLALR 64
K + A A L T A K + +
Sbjct: 175 SAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKAL 234

Query: 65 GENADLRNVNAKYLEKINAE----EEKNKKLEAINKELNENYYKLQDGIDALEKEKEDLK 120
+ ++ ++ + AE E + +LE + I LE EK L+
Sbjct: 235 EGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALE 294

Query: 121 TTLAKTTKENEISEASRKGLSRDLEASRTAKKELEAKHQKLEAENKKLTEGNQVSEASRK 180
A ++++ A+R+ L RDL+ASR AKK+LEA+HQKLE E N++SEASR+
Sbjct: 295 AEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLE-------EQNKISEASRQ 347

Query: 181 GLSNDLEASRAAKKELEAKYQKLETDHQALEAKHQKLEADYQVSETSRKGLSRDLEASRE 240
L DL+ASR AKK+LEA+ HQKLE ++SE SR+ L RDL+ASRE
Sbjct: 348 SLRRDLDASREAKKQLEAE--------------HQKLEEQNKISEASRQSLRRDLDASRE 393

Query: 241 ANKKVTSELTQAKAQLSALE-------ESKKLSEKEKAELQAKLDAQGKALKEQLAKQTE 293
A K+V L +A ++L+ALE ESKKL+EKEKAELQAKL+A+ KALKE+LAKQ E
Sbjct: 394 AKKQVEKALEEANSKLAALEKLNKELEESKKLTEKEKAELQAKLEAEAKALKEKLAKQAE 453

Query: 294 ELAKLRAEKAAGSKTPATKPANNERSGR--AAQTATRPSQNKG----MRSQLPSTGEAAN 347
ELAKLRA KA+ S+TP KP N G+ A Q T+P+QNK + QLPSTGE AN
Sbjct: 454 ELAKLRAGKASDSQTPDAKPGNKAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETAN 513

Query: 348 PFFTAAAATVMVSAGMLALKRKEE 371
PFFTAAA TVM +AG+ A+ +++E
Sbjct: 514 PFFTAAALTVMATAGVAAVVKRKE 537



Score = 82.4 bits (203), Expect = 2e-19
Identities = 84/303 (27%), Positives = 127/303 (41%), Gaps = 15/303 (4%)

Query: 1 MARQQTKKNYSLRKLKTGTASVAVALTVLGAGFANQTEVRADEAKKMEVKESEKESQYKT 60
M + T ++YSLRKLKTGTASVAVALTVLGAG T + A + + EK
Sbjct: 1 MTKNNTNRHYSLRKLKTGTASVAVALTVLGAGLVVNTNEVSAVATRSQTDTLEK------ 54

Query: 61 LALRGENADLRNVNAKYLEKINAEEEKNKKLEAINKELNENYYKLQDGIDALEKEKEDLK 120
++ K+ + N + KN L NK L ++ +L + + +++
Sbjct: 55 ---------VQERADKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLRKND 105

Query: 121 TTLAKTTKENEISEASRKGLSRDLEASRTAKKELEAKHQKLEAENKKLTEGNQVSEASRK 180
+L++ + + EA + L + LE + AK + LEAE L E + +
Sbjct: 106 KSLSEKASKIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALE 165

Query: 181 GLSNDLEASRAAKKELEAKYQKLETDHQALEAKHQKLEADYQVSETSRKGLSRDLEASRE 240
G N A A K LEA+ LE LE + K L + A
Sbjct: 166 GAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAA 225

Query: 241 ANKKVTSELTQAKAQLSALEESKKLSEKEKAELQAKLDAQGKALKEQLAKQTEELAKLRA 300
+ L A +A K E EKA L+A+ KAL+ + T + AK++
Sbjct: 226 RKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKT 285

Query: 301 EKA 303
+A
Sbjct: 286 LEA 288


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1784GPOSANCHOR845e-20 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 84.0 bits (207), Expect = 5e-20
Identities = 150/306 (49%), Positives = 196/306 (64%), Gaps = 21/306 (6%)

Query: 50 KKEAKLSEAELHDKIKNLEEEKAELFEKLDKVEEEHKKVEEEHKKDHEKLEKKSEDVERH 109
+ A KIK LE EKA L + ++E+ + D K++ +
Sbjct: 234 LEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAA- 292

Query: 110 YLRQLDQEYKEQQERQKNLEELERQSQREVEKRYQEQLQKQQQLEKEKQISEASRKSLSR 169
L + + Q + + R+ + ++ + Q+LE++ +ISEASR+SL R
Sbjct: 293 -LEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRR 351

Query: 170 DLEASRAAKKDLEAEHQKLKEEKQISEASRQGLSRDLEASREAKKKVEADLAEANSKLQA 229
DL+ASR AKK LEAEHQKL+E+ +ISEASRQ L RDL+ASREAKK+VE L EANSKL A
Sbjct: 352 DLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQVEKALEEANSKLAA 411

Query: 230 LEKLNKELEEGKKLSEKEKAELQAKLEAEAKALKEQLAKQAEELAKLK-----GNQTPNA 284
LEKLNKELEE KKL+EKEKAELQAKLEAEAKALKE+LAKQAEELAKL+ +QTP+A
Sbjct: 412 LEKLNKELEESKKLTEKEKAELQAKLEAEAKALKEKLAKQAEELAKLRAGKASDSQTPDA 471

Query: 285 KVAPQA--------------NRSRSAMTQQKRTLPSTGETANPFFTAAAATVMVSAGMLA 330
K +A N++++ M + KR LPSTGETANPFFTAAA TVM +AG+ A
Sbjct: 472 KPGNKAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETANPFFTAAALTVMATAGVAA 531

Query: 331 LKRKEE 336
+ +++E
Sbjct: 532 VVKRKE 537



Score = 50.4 bits (120), Expect = 4e-09
Identities = 68/304 (22%), Positives = 118/304 (38%), Gaps = 7/304 (2%)

Query: 1 MARKDTNKQYSLRKLKTGTASVAVAVAVLGAGFANQTTVKANSKNPVPVKKEAKLSEAEL 60
M + +TN+ YSLRKLKTGTASVAVA+ VLGAG T + K+ E
Sbjct: 1 MTKNNTNRHYSLRKLKTGTASVAVALTVLGAGLVVNTNEVSAVATRSQTDTLEKVQER-- 58

Query: 61 HDKIKNLEEEKAELFEKLDKVEEEHKKVEEEHKKDHEKLEKKSEDVERHYLRQLDQEYKE 120
E E L K + +K +++ + + E+L E + ++ ++ K
Sbjct: 59 ---ADKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLRKNDKSLSEKASKI 115

Query: 121 QQERQKNLEELERQSQREVEKRYQEQLQKQQQLEKEKQISEASRKSLSRDLEASRAAKKD 180
Q+ + + ++ K + LE EK A + L + LE +
Sbjct: 116 QELEARKAD--LEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTA 173

Query: 181 LEAEHQKLKEEKQISEASRQGLSRDLEASREAKKKVEADLAEANSKLQALEKLNKELEEG 240
A+ + L+ EK EA + L + LE + A + ++ AL +LE+
Sbjct: 174 DSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKA 233

Query: 241 KKLSEKEKAELQAKLEAEAKALKEQLAKQAEELAKLKGNQTPNAKVAPQANRSRSAMTQQ 300
+ + AK++ A+QAE L+G + + + +
Sbjct: 234 LEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAAL 293

Query: 301 KRTL 304
+
Sbjct: 294 EAEK 297



Score = 42.0 bits (98), Expect = 2e-06
Identities = 52/206 (25%), Positives = 90/206 (43%), Gaps = 2/206 (0%)

Query: 50 KKEAKLSEAELHDKIKNLEEEKAELFEKLDKVEEEHKKVEEEHKKDHEKLEKKSEDVERH 109
+ A KIK LE EKA L + ++E+ + D K++ +
Sbjct: 164 LEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKA-- 221

Query: 110 YLRQLDQEYKEQQERQKNLEELERQSQREVEKRYQEQLQKQQQLEKEKQISEASRKSLSR 169
L + ++ E N + + +E +Q +LEK + + + S
Sbjct: 222 ALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSA 281

Query: 170 DLEASRAAKKDLEAEHQKLKEEKQISEASRQGLSRDLEASREAKKKVEADLAEANSKLQA 229
++ A K LEAE L+ + Q+ A+RQ L RDL+ASREAKK++EA+ + + +
Sbjct: 282 KIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNKI 341

Query: 230 LEKLNKELEEGKKLSEKEKAELQAKL 255
E + L S + K +L+A+
Sbjct: 342 SEASRQSLRRDLDASREAKKQLEAEH 367


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1785GPOSANCHOR1377e-38 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 137 bits (347), Expect = 7e-38
Identities = 127/353 (35%), Positives = 187/353 (52%), Gaps = 17/353 (4%)

Query: 89 SKLMQQMYKETLQKKEELDTLSKALTHTIEKKIESENAYKKELGQLKAAAEAEAQKALDA 148
+ Q ++ L+ T A T+E + + A K +L + A +
Sbjct: 188 LEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAK 247

Query: 149 LNNKNKQISDLTNENAQLKEAIEGYVQ-------TIQNASREMAAKQQELAAAKSQLEAK 201
+ + + L A+L++A+EG + I+ E AA + E A + Q +
Sbjct: 248 IKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVL 307

Query: 202 NAEIEALKQQDASKTEELAKLQSEAATLENLLGSAKRELTELQAKLDTATAEKAKLESQV 261
NA ++L++ + E +L++E LE ++ L+ LD + K +LE++
Sbjct: 308 NANRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQLEAEH 367

Query: 262 TTLENLLGSAKRELTDLQAKLDAANAEKEKLQSQAAALEKQLEATKKELADLQAKLAATN 321
LE ++ L+ LDA+ K++++ +L A +K +L+ T
Sbjct: 368 QKLEEQNKISEASRQSLRRDLDASREAKKQVEKALEEANSKLAALEKLNKELEESKKLTE 427

Query: 322 QEKE----KLEAEAKALKEQLAKQAEELAKLKADKASGAQKPDTKPGNKEVPTR----PS 373
+EK KLEAEAKALKE+LAKQAEELAKL+A KAS +Q PD KPGNK VP + +
Sbjct: 428 KEKAELQAKLEAEAKALKEKLAKQAEELAKLRAGKASDSQTPDAKPGNKAVPGKGQAPQA 487

Query: 374 QTRTNTNKAPMAQTKRQLPSTGEETTNPFFTAAALTVIASAGVLA-LKRKEEN 425
T+ N NKAPM +TKRQLPSTG ET NPFFTAAALTV+A+AGV A +KRKEEN
Sbjct: 488 GTKPNQNKAPMKETKRQLPSTG-ETANPFFTAAALTVMATAGVAAVVKRKEEN 539



Score = 84.0 bits (207), Expect = 1e-19
Identities = 94/352 (26%), Positives = 154/352 (43%), Gaps = 13/352 (3%)

Query: 1 MSKRNPNKHYSLRKLKTGTASVAVALTVLGAGLANTTDVKAETVGRFSDEQVRKAREKAI 60
M+K N N+HYSLRKLKTGTASVAVALTVLGAGL T+ + R + + K +E+A
Sbjct: 1 MTKNNTNRHYSLRKLKTGTASVAVALTVLGAGLVVNTNEVSAVATRSQTDTLEKVQERA- 59

Query: 61 EDVFDGYTGARSVYQSGNLPNRLTPTKLSKLMQQMYKETLQKKEELDTLSKALTHTIEKK 120
D + + + N L ++ +E KE+L K+L+ K
Sbjct: 60 ----DKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLRKNDKSLSEK-ASK 114

Query: 121 IESENAYKKELGQLKAAAEAEAQKALDALNNKNKQISDLTNENAQLKEAIEGYVQTIQNA 180
I+ A K +L + A + + + + L A L++A+EG + N
Sbjct: 115 IQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAM----NF 170

Query: 181 SREMAAKQQELAAAKSQLEAKNAEIEALKQQDASKTEELAKLQSEAATLENLLGSAKREL 240
S +AK + L A K+ LEA+ AE+E + ++ TLE +
Sbjct: 171 STADSAKIKTLEAEKAALEARQAELEKALEG---AMNFSTADSAKIKTLEAEKAALAARK 227

Query: 241 TELQAKLDTATAEKAKLESQVTTLENLLGSAKRELTDLQAKLDAANAEKEKLQSQAAALE 300
+L+ L+ A +++ TLE + + +L+ L+ A ++ LE
Sbjct: 228 ADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLE 287

Query: 301 KQLEATKKELADLQAKLAATNQEKEKLEAEAKALKEQLAKQAEELAKLKADK 352
+ A + E ADL+ + N ++ L + A +E + E KL+
Sbjct: 288 AEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQN 339



Score = 30.4 bits (68), Expect = 0.016
Identities = 36/203 (17%), Positives = 75/203 (36%)

Query: 160 TNENAQLKEAIEGYVQTIQNASREMAAKQQELAAAKSQLEAKNAEIEALKQQDASKTEEL 219
T+ +++E + + + + A K + E+ K++ + L
Sbjct: 49 TDTLEKVQERADKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLRKNDKSL 108

Query: 220 AKLQSEAATLENLLGSAKRELTELQAKLDTATAEKAKLESQVTTLENLLGSAKRELTDLQ 279
++ S+ LE ++ L +A+ LE++ L ++ L
Sbjct: 109 SEKASKIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAM 168

Query: 280 AKLDAANAEKEKLQSQAAALEKQLEATKKELADLQAKLAATNQEKEKLEAEAKALKEQLA 339
A +A+ + L+++ AALE + +K L A + + + LEAE AL + A
Sbjct: 169 NFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKA 228

Query: 340 KQAEELAKLKADKASGAQKPDTK 362
+ L + + K T
Sbjct: 229 DLEKALEGAMNFSTADSAKIKTL 251


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1786PF050435390.0 Transcriptional activator
		>PF05043#Transcriptional activator

Length = 493

Score = 539 bits (1390), Expect = 0.0
Identities = 108/491 (21%), Positives = 218/491 (44%), Gaps = 16/491 (3%)

Query: 16 RELKLISYLTENSNAIGVKDKELSKALNISMLTLQSCLTNMQFMKEVGGITYKDGYINIW 75
R+L+L+ L E+ EL++ LN + ++ L++++ I I
Sbjct: 11 RQLELLELLFEHKRWFHRS--ELAELLNCTERAVKDDLSHVKSAFPDLIFHSSTNGIRII 68

Query: 76 YHQCCGLQEVYQKALRESPSLKLLELLFFRDFSSLEELAEELFVSLSTLKRLIKKTNTYL 135
++ VY + S +LE +FF + E + +E ++S S+L R+I + N +
Sbjct: 69 NTDDSDIEMVYHHFFKHSTHFSILEFIFFNEGCQAESICKEFYISSSSLYRIISQINKVI 128

Query: 136 SHTFAISIVTSPVQVSGDERQIRLFYLKYFSEAYKISEWPFGDILNLKNCERLLSLLIKE 195
F + +PVQ+ G+ER IR F+ +YFSE Y EWPF + + + +LL L+ KE
Sbjct: 129 KRQFQFEVSLTPVQIIGNERDIRYFFAQYFSEKYYFLEWPFEN-FSSEPLSQLLELVYKE 187

Query: 196 VDVKVHFTLFQHLKILSGVNLIRYYKGYSCSYNNKKTSHRFSQLIQHSSEIQDLSRLFYL 255
++ + + LK+L NL R G+ + + + + + I+ +++ F
Sbjct: 188 TSFPMNLSTHRMLKLLLVTNLYRIKFGHFMEVDKDSFNDQSLDFLMQAEGIEGVAQSFES 247

Query: 256 KFGLHLDEYTIAEMFSNHLNDKLEIGCAFEIIDQDPTSGGRQVTNWIHLL----DEMEIK 311
++ + LDE + ++F ++ I E + V HLL D++ +K
Sbjct: 248 EYNISLDEEVVCQLFVSYFQKMFFID---ESLFMKCVKKDSYVEKSYHLLSDFIDQISVK 304

Query: 312 LNLSITNKYEVAVTLHNASVLNEEDITANYLLFDYKKSYLNFYQKEHPRIYEPFVTSVEK 371
+ I NK + LHN + L +++ ++LFD K + + +Q P+ +
Sbjct: 305 YQIEIENKDNLIWHLHNTAHLYRQELFTEFILFDQKGNTIRNFQNIFPKFVSDVKKELSH 364

Query: 372 LMQADNAQVSKELINQLTYCFFITWENSFLKVNQKDEKVRLLVI----ERSYNSVGNFLK 427
++ S ++N L+Y F ++ + + Q K+++LV+ + V L
Sbjct: 365 YLETLEVCSSSMMVNHLSYTFITHTKHLVINLLQNQPKLKVLVMSNFDQYHAKFVAETLS 424

Query: 428 KYIGEFFSITNFDELDCLTIDLVEIEKQYDVIVTDVMVGKSEELEIFFFYKMIPEAIIDR 487
Y F + + EL+ L + YD+I+++ ++ E + + + ++I
Sbjct: 425 YYCSNNFELEVWTELELSKESLE--DSPYDIIISNFIIPPIENKRLIYSNNINTVSLIYL 482

Query: 488 LNEFLNVSFTD 498
LN + + +
Sbjct: 483 LNAMMFIRLDE 493


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1789PF03544330.002 Gram-negative bacterial tonB protein
		>PF03544#Gram-negative bacterial tonB protein

Length = 243

Score = 33.4 bits (76), Expect = 0.002
Identities = 14/90 (15%), Positives = 26/90 (28%), Gaps = 3/90 (3%)

Query: 108 TKQPDSSDQSTPSPKDQSSQKE-SQNKDGRPTPSPDQQKDQTPDKTPEKSADKTPEKGPE 166
+ + + P + + + +P P P + + P+ PE + E
Sbjct: 38 HQVIELPAPAQPISVTMVAPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVI--E 95

Query: 167 KSAKKTPEPNRDAPKPIQPPLAAAAPVFAP 196
K K + K QP P
Sbjct: 96 KPKPKPKPKPKPVKKVEQPKRDVKPVESRP 125



Score = 33.0 bits (75), Expect = 0.002
Identities = 19/84 (22%), Positives = 30/84 (35%), Gaps = 6/84 (7%)

Query: 139 PSPDQQKD---QTPDKTPEK---SADKTPEKGPEKSAKKTPEPNRDAPKPIQPPLAAAAP 192
P+P Q P P PE + PEP ++AP I+ P P
Sbjct: 44 PAPAQPISVTMVAPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKP 103

Query: 193 VFAPWRESDKDLSKLKPSSRSSAA 216
P ++ ++ +KP A+
Sbjct: 104 KPKPVKKVEQPKRDVKPVESRPAS 127



Score = 33.0 bits (75), Expect = 0.002
Identities = 14/94 (14%), Positives = 23/94 (24%), Gaps = 4/94 (4%)

Query: 104 DKNDTKQPDSSDQSTPSPKDQSSQKESQNKDGRPTPSPDQQKDQTPDKTPEKSADKTPEK 163
+ P T ++ P P+ + + P+ E K
Sbjct: 39 QVIELPAPAQPISVTMVAPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPK 98

Query: 164 GPE----KSAKKTPEPNRDAPKPIQPPLAAAAPV 193
K KK +P RD P +
Sbjct: 99 PKPKPKPKPVKKVEQPKRDVKPVESRPASPFENT 132


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1790MECHCHANNEL320.002 Bacterial mechano-sensitive ion channel signature.
		>MECHCHANNEL#Bacterial mechano-sensitive ion channel signature.

Length = 136

Score = 32.1 bits (73), Expect = 0.002
Identities = 14/62 (22%), Positives = 28/62 (45%), Gaps = 8/62 (12%)

Query: 10 VINGLIIVVVTSILLVLYFAMPIYYTKVKDKEVKREFDQTSKQIKGKTVTEIRDILTKKI 69
V + LI+ ++ A+ + + KE +K+ +TEIRD+L ++
Sbjct: 82 VFDFLIVA------FAIFMAIKLINKLNRKKEEPAAAPAPTKEEV--LLTEIRDLLKEQN 133

Query: 70 NK 71
N+
Sbjct: 134 NR 135


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1791HTHFIS831e-20 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 83.0 bits (205), Expect = 1e-20
Identities = 31/128 (24%), Positives = 55/128 (42%), Gaps = 1/128 (0%)

Query: 3 KILVVEDDDTISQVICEFLKANNYDPDCVFDGQAALDKWQTTSYDLIILDIMLPSLSGLE 62
ILV +DD I V+ + L YD + DL++ D+++P + +
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64

Query: 63 VLKTIRKT-SDVPIIMLTALDDEYTQLVSFNHLISDYVTKPFSPLILIKRIENVLRVSTP 121
+L I+K D+P+++++A + T + + DY+ KPF LI I L
Sbjct: 65 LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKR 124

Query: 122 DEKRQIGD 129
+ D
Sbjct: 125 RPSKLEDD 132


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1794RTXTOXIND544e-10 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 54.4 bits (131), Expect = 4e-10
Identities = 34/144 (23%), Positives = 55/144 (38%), Gaps = 10/144 (6%)

Query: 60 DISLTLAGEVTANNSSKVKIDSSKGEVKDVFVKKGDVVKVGQPLFSYETSQRLTAQSSEF 119
+I T G++T + SK VK++ VK+G+ V+ G L +LTA +E
Sbjct: 81 EIVATANGKLTHSGRSKEIKPIENSIVKEIIVKEGESVRKGDVLL------KLTALGAEA 134

Query: 120 DVQTKANQLQVAKTNAALKWETYNRKVNEINTLKSRYNTAPDESLLEQIRSAEDSVSQAL 179
D + Q + A L+ Y I K PDE + + E +L
Sbjct: 135 DTL----KTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSL 190

Query: 180 SDAKTADSDVKTAQIELDKANATA 203
+ + + Q EL+ A
Sbjct: 191 IKEQFSTWQNQKYQKELNLDKKRA 214



Score = 39.4 bits (92), Expect = 2e-05
Identities = 28/180 (15%), Positives = 61/180 (33%), Gaps = 16/180 (8%)

Query: 120 DVQTKANQLQVAKTNAALKWETYNRKVNEINTLKSRYNTAPDESL---LEQIRSAEDSVS 176
D + ++ +AK + Y VNE+ KS+ E L E + +
Sbjct: 239 DFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKN 298

Query: 177 QALSDAKTADSDVKTAQIELDKANATATTEKGKLEYDTVKSDTAGTIVSLNTDLPNQSKS 236
+ L + ++ +EL K + + +++ + + L
Sbjct: 299 EILDKLRQTTDNIGLLTLELAKNEE-------RQQASVIRAPVSVKVQQLKVHTEGGVV- 350

Query: 237 KKENETFMEII-DKSKMLVKGNISEFDRDKLKIGQKVEV-IDRKDNSK--KWTGKVTQVG 292
ET M I+ + + V + D + +GQ + ++ ++ GKV +
Sbjct: 351 -TTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNIN 409


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1797IGASERPTASE442e-06 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 43.9 bits (103), Expect = 2e-06
Identities = 49/262 (18%), Positives = 80/262 (30%), Gaps = 23/262 (8%)

Query: 361 KPAEDERSSQATEPANPSKEDSSTDASQGSHDSENPATDSPSQPQAPDQGNHQSQVPNDK 420
+ QA P+ PS + + PAT S + + +S+
Sbjct: 995 TNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVAENSKQESKTVEKN 1054

Query: 421 PQ-----------TDKTDTPNVPAPPQDTPKAPEAGGQSGPAGNTEEKAPDSGPKESDQ- 468
Q K NV A Q T + ++G ++ TE K + KE
Sbjct: 1055 EQDATETTAQNREVAKEAKSNVKANTQ-TNEVAQSGSETKETQTTETKETATVEKEEKAK 1113

Query: 469 ---SSSKESPSVGEDTTPNQPDVLVGGQSEPIDITEDTITDAPPTVSGHNASTQPQSVAE 525
++E P V +P Q QSE + + + PTV+ +Q + A+
Sbjct: 1114 VETEKTQEVPKVTSQVSPKQE------QSETVQPQAEPARENDPTVNIKEPQSQTNTTAD 1167

Query: 526 DTAPQRPDVLVGGQSEPIDITQDTQPGMSGSNDATVINEDTKPKRVFHFDNKEPQASEKA 585
P + Q T +T + N T+P NK ++
Sbjct: 1168 TEQPAKETSSNVEQPVTESTTVNTGNSVV-ENPENTTPATTQPTVNSESSNKPKNRHRRS 1226

Query: 586 AEQKLAPHDSHTTPQTSDDTAA 607
+ TT T A
Sbjct: 1227 VRSVPHNVEPATTSSNDRSTVA 1248



Score = 37.0 bits (85), Expect = 3e-04
Identities = 31/223 (13%), Positives = 64/223 (28%), Gaps = 14/223 (6%)

Query: 237 ELLGLKAEIDQLTKDNPKNDRLETLMWESKFTLSDFRRTSRLSAYYTQEDYVDKVVLSEE 296
E + ++ + T + + D ET + TQ + V + +
Sbjct: 1038 ETVAENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVK----ANTQTNEVAQSGSETK 1093

Query: 297 APNLRTAKEKVKTLKGILYDYYVETNDLEKAKQYRVEDETSPSQPEAPAKPEAPTPSPSP 356
KE K VET ++ + + Q E P P
Sbjct: 1094 ETQTTETKETATVEKE--EKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEPARENDP 1151

Query: 357 APGQKPAEDERSSQATEPANPSKEDSSTDASQGSHDSENPATDSPSQPQAPDQGNHQSQV 416
K + + ++ A P+KE SS + + +S + N ++
Sbjct: 1152 TVNIKEPQSQTNTTADT-EQPAKETSSNVEQPVTESTTVNTGNSVVE-------NPENTT 1203

Query: 417 PNDKPQTDKTDTPNVPAPPQDTPKAPEAGGQSGPAGNTEEKAP 459
P T +++ N P ++ +++
Sbjct: 1204 PATTQPTVNSESSNKPKNRHRRSVRSVPHNVEPATTSSNDRST 1246


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1798IGASERPTASE320.019 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 31.6 bits (71), Expect = 0.019
Identities = 28/140 (20%), Positives = 47/140 (33%), Gaps = 14/140 (10%)

Query: 24 APTVLGQEVSASTTSTETSAASAGVGTSGTAASETGSGAAVATATTTTATTNGGPQSTPA 83
PTV +E + T +T + A +S T S TT T N ++
Sbjct: 1150 DPTVNIKEPQSQTNTTADTEQPAKETSSNVEQPVTES--------TTVNTGNSVVENPEN 1201

Query: 84 VAEATPQPQAQIAPVAAATSTSSASSSSDGKAPQAVTSSTSPSTPAA------ASSNGSN 137
AT QP + S S + T+S++ + A ++N
Sbjct: 1202 TTPATTQPTVNSESSNKPKNRHRRSVRSVPHNVEPATTSSNDRSTVALCDLTSTNTNAVL 1261

Query: 138 QEASAETEPQTMEVEKYTVD 157
+A A+ + + V K
Sbjct: 1262 SDARAKAQFVALNVGKAVSQ 1281


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy179960KDINNERMP250.043 60kDa inner membrane protein signature.
		>60KDINNERMP#60kDa inner membrane protein signature.

Length = 548

Score = 24.9 bits (54), Expect = 0.043
Identities = 4/24 (16%), Positives = 7/24 (29%)

Query: 22 YSKKVLTDEPTGYQPPAAHGPCDD 45
+ + + T AA D
Sbjct: 27 KNPQPQAQQTTQTTTTAAGSAADQ 50


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1802STREPTOPAIN604e-14 Streptopain (C10) cysteine protease family signature.
		>STREPTOPAIN#Streptopain (C10) cysteine protease family signature.

Length = 398

Score = 59.7 bits (144), Expect = 4e-14
Identities = 39/102 (38%), Positives = 56/102 (54%), Gaps = 7/102 (6%)

Query: 2 EMHFVRTEPEARRIAETFCAENTQTKTPMRVQQLSYPSDTDHSGGEL-----YIYALSPA 56
+ +F R E EA+ A TF ++ K R + D + GGEL Y+Y +S
Sbjct: 28 DQNFARNEKEAKDSAITFIQKSAAIKAGARSAE-DIKLDKVNLGGELSGSNMYVYNISTG 86

Query: 57 GFIIVSGDTRAHTILGYSFDNNLDLN-HDNVRSMIEAYQKQI 97
GF+IVSGD R+ ILGYS + D N +N+ S +E+Y +QI
Sbjct: 87 GFVIVSGDKRSPEILGYSTSGSFDANGKENIASFMESYVEQI 128


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10270_Spy1803STREPTOPAIN7100.0 Streptopain (C10) cysteine protease family signature.
		>STREPTOPAIN#Streptopain (C10) cysteine protease family signature.

Length = 398

Score = 710 bits (1833), Expect = 0.0
Identities = 396/398 (99%), Positives = 397/398 (99%)

Query: 1 MNKKKLGIRLLSLLALGGFVLANPVFADQNFARNEKEAKDSAITFIQKSAAIKAGARSAE 60
MNKKKLG+RLLSLLALGGFVLANPVFADQNFARNEKEAKDSAITFIQKSAAIKAGARSAE
Sbjct: 1 MNKKKLGVRLLSLLALGGFVLANPVFADQNFARNEKEAKDSAITFIQKSAAIKAGARSAE 60

Query: 61 DIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASF 120
DIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASF
Sbjct: 61 DIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASF 120

Query: 121 MESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGE 180
MESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGE
Sbjct: 121 MESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGE 180

Query: 181 QSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQY 240
QSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQY
Sbjct: 181 QSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQY 240

Query: 241 NWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQ 300
NWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQ
Sbjct: 241 NWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQ 300

Query: 301 SVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWG 360
SVHQINR DFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWG
Sbjct: 301 SVHQINRGDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWG 360

Query: 361 GVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP 398
GVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP
Sbjct: 361 GVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP 398



 
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