PredictBias

identification of genomic and pathogenicity islands in prokaryotic genome
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A) Input parameters
Genome2466.gbkThreshold dinucleotide bias2
Threshold codon bias4Threshold %GC bias3
E-value (RPSBlast)0.05Genome (non-pathogenic)
 
B) Compare a potential GI or PAI in related non-pathogenic sp. (phylogenetic tree)
Potential GI or PAI start    end  
Select Organism     
 
C) Potential GIs and PAIs in NC_008024 (download)
S.NoStartEndBiasVirulenceInsertion elementsPrediction
1MGAS10750_Spy0103MGAS10750_Spy0115Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy0103-2163.503145pyrroline-5-carboxylate reductase
MGAS10750_Spy0104-3132.518662glutamyl aminopeptidase
MGAS10750_Spy01050130.402751hypothetical protein
MGAS10750_Spy0106-3152.499136hypothetical protein
MGAS10750_Spy0107-2173.022151Thioredoxin
MGAS10750_Spy0108-2161.058708tRNA binding domain protein
MGAS10750_Spy0109-1130.445777single-stranded DNA-binding protein
MGAS10750_Spy0110011-0.274278deoxyadenosine kinase / deoxyguanosine kinase
MGAS10750_Spy0111111-0.537258tRNA-dihydrouridine synthase
MGAS10750_Spy0112212-1.080826Hsp33-like chaperonin
MGAS10750_Spy0113214-1.464789RofA family transcriptional regulator
MGAS10750_Spy0114215-0.970212Fibronectin-binding protein
MGAS10750_Spy0115216-0.950166Fibronectin-binding protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0113PF082808020.0 M protein trans-acting positive regulator
		>PF08280#M protein trans-acting positive regulator

Length = 530

Score = 802 bits (2073), Expect = 0.0
Identities = 522/530 (98%), Positives = 522/530 (98%)

Query: 1 MISIFSLDRIEIGEYTYQRLIWLSKCRKRGPLYLIEKYLESSIESKCQLVVLFFKTSYLP 60
MISIFSLDRIEIGEYTYQRLIWLSKCRKRGPL LIEKYLESSIESKCQLVVLFFKTS LP
Sbjct: 1 MISIFSLDRIEIGEYTYQRLIWLSKCRKRGPLSLIEKYLESSIESKCQLVVLFFKTSSLP 60

Query: 61 ITEVAEKTGLTFLQLNHYCEELNAFFPGSLSMTIQKRMISCQFTHPFKETYLYQLYASSN 120
ITEVAEKTGLTFLQLNHYCEELNAFFP SLSMTIQKRMISCQFTHP KETYLYQLYASSN
Sbjct: 61 ITEVAEKTGLTFLQLNHYCEELNAFFPDSLSMTIQKRMISCQFTHPSKETYLYQLYASSN 120

Query: 121 VLQLLAFLIKNGSHSRPLTDFARSHFLSNSSAYRMREALIPLLRNFELKLSKNKIVGEEY 180
VLQLLAFLIKNGSHSRPLTDFARSHFLSNSSAYRMREALIPLLRNFELKLSKNKIVGEEY
Sbjct: 121 VLQLLAFLIKNGSHSRPLTDFARSHFLSNSSAYRMREALIPLLRNFELKLSKNKIVGEEY 180

Query: 181 RIRYLIALLYSKFGIKVYDLTQQDKNTIHSFLSHSSTHLKTSPWLSESFSFYDILLALSW 240
RIRYLIALLYSKFGIKVYDLTQQDKN IHSFLSHSSTHLKTSPWLSESFSFYDILLALSW
Sbjct: 181 RIRYLIALLYSKFGIKVYDLTQQDKNIIHSFLSHSSTHLKTSPWLSESFSFYDILLALSW 240

Query: 241 KRHQFSVTIPQTRIFQQLKKLFVYDSLKKSSHDIIETYCQLNFSAGDLDYLYLIYITANN 300
KRHQFSVTIPQTRIFQQLKKLFVYDSLKKSS DIIETYCQLNFSAGDLDYLYLIYITANN
Sbjct: 241 KRHQFSVTIPQTRIFQQLKKLFVYDSLKKSSRDIIETYCQLNFSAGDLDYLYLIYITANN 300

Query: 301 SFASLQWTPEHTRQCCQLFEENDTFRLLLNPIITLLPNLKEQKASLVKALMFFSKSFLFN 360
SFASLQWTPEH RQCCQLFEENDTFRLLLNPIITLLPNLKEQKASLVKALMFFSKSFLFN
Sbjct: 301 SFASLQWTPEHIRQCCQLFEENDTFRLLLNPIITLLPNLKEQKASLVKALMFFSKSFLFN 360

Query: 361 LQHFIPETNLFVSPYYKGNQKLYTSLKLIVEEWMAKLPGKRYLNHKHFHLFCHYVEQILR 420
LQHFIPETNLFVSPYYKGNQKLYTSLKLIVEEWMAKLPGKRYLNHKHFHLFCHYVEQILR
Sbjct: 361 LQHFIPETNLFVSPYYKGNQKLYTSLKLIVEEWMAKLPGKRYLNHKHFHLFCHYVEQILR 420

Query: 421 NIQPPLVVVFVASNFINAHLLTDSFPRYFSDKSIDFHSYYLLQDNVYQIPDLKPDLVITH 480
NIQPPLVVVFVASNFINAHLLTDSFPRYFSDKSIDFHSYYLLQDNVYQIPDLKPDLVITH
Sbjct: 421 NIQPPLVVVFVASNFINAHLLTDSFPRYFSDKSIDFHSYYLLQDNVYQIPDLKPDLVITH 480

Query: 481 SQLIPFVQHELTKGIAVAEISFDESILSIQELMYQVKEEKFQADLTKQLT 530
SQLIPFV HELTKGIAVAEISFDESILSIQELMYQVKEEKFQADLTKQLT
Sbjct: 481 SQLIPFVHHELTKGIAVAEISFDESILSIQELMYQVKEEKFQADLTKQLT 530


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0114PF03544310.010 Gram-negative bacterial tonB protein
		>PF03544#Gram-negative bacterial tonB protein

Length = 243

Score = 31.1 bits (70), Expect = 0.010
Identities = 18/85 (21%), Positives = 27/85 (31%), Gaps = 5/85 (5%)

Query: 275 PPRPGETPEYGPKTPELDGSPIPEDPKHPDDNLEPTLPPVMLDGEEVPEVPSESLEPALP 334
PP+ + P PE + PIPE PK +E P + P + +E
Sbjct: 62 PPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPK-----PKPKPKPVKKVEQPKR 116

Query: 335 PLMPELDGQEVPEVPSESLEPALPP 359
+ P P + P
Sbjct: 117 DVKPVESRPASPFENTAPARPTSST 141


2MGAS10750_Spy0128MGAS10750_Spy0136Y        NNGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy0128315-0.287296translation initiation inhibitor
MGAS10750_Spy0129213-0.379769PfoR family transcriptional regulator
MGAS10750_Spy0130314-0.723794hypothetical protein
MGAS10750_Spy01310111.672132V-type ATP synthase subunit I
MGAS10750_Spy0132-3123.392807V-type ATP synthase subunit K
MGAS10750_Spy0133-3113.010886V-type sodium ATP synthase subunit E
MGAS10750_Spy0134-3133.202235V-type sodium ATP synthase subunit C
MGAS10750_Spy0135-3123.177543V-type ATP synthase subunit F
MGAS10750_Spy0136-2113.516318V-type ATP synthase subunit A
3MGAS10750_Spy0148MGAS10750_Spy0155Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy01481224.977078hypothetical protein
MGAS10750_Spy01491264.673166hypothetical protein
MGAS10750_Spy01501264.608698hypothetical protein
MGAS10750_Spy01510254.590590hypothetical protein
MGAS10750_Spy01520254.949107cystathionine beta-lyase
MGAS10750_Spy01531285.328482leucyl-tRNA synthetase
MGAS10750_Spy01541234.594756PTS system ascorbate-specific transporter
MGAS10750_Spy01551214.935273PTS system, 3-keto-L-gulonate specific IIB
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0148BACTRLTOXIN260.031 Bacterial toxin signature.
		>BACTRLTOXIN#Bacterial toxin signature.

Length = 266

Score = 26.4 bits (58), Expect = 0.031
Identities = 10/29 (34%), Positives = 20/29 (68%), Gaps = 1/29 (3%)

Query: 10 RFVYLLVALFAALLLIARP-VMADEENDP 37
F+ ++ +FA +L+I+ P V+A+ + DP
Sbjct: 5 LFISRVILIFALILVISTPNVLAESQPDP 33


4MGAS10750_Spy0327MGAS10750_Spy0361Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy03272180.431340DNA polymerase III subunit delta'
MGAS10750_Spy0328218-0.237706Tpl protein
MGAS10750_Spy03290191.765719Signal peptidase-like protein
MGAS10750_Spy03300181.864456DNA replication intiation control protein YabA
MGAS10750_Spy03312202.801336Tetrapyrrole (Corrin/Porphyrin) methylase family
MGAS10750_Spy0332-1193.350732Tetrapyrrole (Corrin/Porphyrin) methylase family
MGAS10750_Spy0333-2163.181689hypothetical protein
MGAS10750_Spy0334-2163.408045Copper homeostasis protein cutC
MGAS10750_Spy0336-1172.859009hypothetical protein
MGAS10750_Spy0335-1182.972582arsenate reductase
MGAS10750_Spy0337-1193.150223exodeoxyribonuclease III
MGAS10750_Spy0338-1202.892219L-lactate oxidase
MGAS10750_Spy03390212.612097endopeptidase lactocepin
MGAS10750_Spy0340-2201.821462interleukin-8 protease
MGAS10750_Spy0341-2230.923717hypothetical protein
MGAS10750_Spy0342-2162.907097hypothetical protein
MGAS10750_Spy0343-2162.657819hypothetical protein
MGAS10750_Spy0344-1183.261306transposase
MGAS10750_Spy0345-2193.470113transposase
MGAS10750_Spy0346-1255.239877hypothetical protein
MGAS10750_Spy0347-1265.487411methionyl-tRNA synthetase
MGAS10750_Spy03480336.532069hypothetical protein
MGAS10750_Spy0349-1305.892289ribonucleotide-diphosphate reductase subunit
MGAS10750_Spy03500285.684223ribonucleotide reductase stimulatory protein
MGAS10750_Spy03510296.065178ribonucleotide-diphosphate reductase subunit
MGAS10750_Spy03521263.657031hypothetical protein
MGAS10750_Spy03531252.367067C3 family ADP-ribosyltransferase
MGAS10750_Spy0354324-2.794981hypothetical protein
MGAS10750_Spy0355024-2.834197hypothetical protein
MGAS10750_Spy0356024-1.367079hypothetical protein
MGAS10750_Spy0357-221-1.150482hypothetical protein
MGAS10750_Spy03581190.516967hypothetical protein
MGAS10750_Spy03590141.866355hypothetical protein
MGAS10750_Spy03600172.987051hypothetical protein
MGAS10750_Spy03610173.0667403-ketoacyl-(acyl-carrier-protein) reductase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0328PF05844270.013 YopD protein
		>PF05844#YopD protein

Length = 295

Score = 26.5 bits (58), Expect = 0.013
Identities = 10/39 (25%), Positives = 20/39 (51%), Gaps = 1/39 (2%)

Query: 13 SKDLPVATKVAAHRGKKAFEENTAFATDLMKEVSRLITQ 51
+++ V + + +K E+ +F MK+V +LI Q
Sbjct: 242 AREEEVNATIGQSQKQKV-EDQMSFDAGFMKDVLQLIQQ 279


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0339SUBTILISIN918e-22 Subtilisin serine protease family (S8) signature.
		>SUBTILISIN#Subtilisin serine protease family (S8) signature.

Length = 326

Score = 90.7 bits (225), Expect = 8e-22
Identities = 42/160 (26%), Positives = 64/160 (40%), Gaps = 24/160 (15%)

Query: 264 DIDWTQTDDDTKYESHGMHVTGIVAGNSKEAAATGERFLGIAPEAQVMFMRVFANDVMGS 323
+ D D HG HV G +A +G+APEA ++ ++V G
Sbjct: 74 EGDPEIFKDY---NGHGTHVAGTIAAT-----ENENGVVGVAPEADLLIIKVLNKQGSGQ 125

Query: 324 AESLFIKAIEDAVALGADVINLSLGTANGAQLSGSKPLMEAIEKAKKAGVSVVVAAGNER 383
+ + I+ I A+ D+I++SLG L EA++KA + + V+ AAGNE
Sbjct: 126 YDWI-IQGIYYAIEQKVDIISMSLGGP-----EDVPELHEAVKKAVASQILVMCAAGNEG 179

Query: 384 VYGSDHDDPLATNPDYGLVGSPSTGRTPTSVAAINSKWVI 423
D+ +G P SV AIN
Sbjct: 180 DGDDRTDE----------LGYPGCYNEVISVGAINFDRHA 209



Score = 77.6 bits (191), Expect = 2e-17
Identities = 36/147 (24%), Positives = 58/147 (39%), Gaps = 18/147 (12%)

Query: 561 FDSVVSKAPSQKGNEMNHFSNWGLTSDGYLKPDITAPGGDIYSTYNDNHYGSQTGTSMAS 620
++ V+S + FSN + D+ APG DI ST Y + +GTSMA+
Sbjct: 194 YNEVISVGAINFDRHASEFSNSNN------EVDLVAPGEDILSTVPGGKYATFSGTSMAT 247

Query: 621 PQIAGASLLVKQ-YLEKTQPNLPKEKIADIVKNLLMSNAQIHVNPETKTTTSPRQQGAGL 679
P +AGA L+KQ + +L + L+ SP+ +G GL
Sbjct: 248 PHVAGALALIKQLANASFERDL----TEPELYAQLIKRT-------IPLGNSPKMEGNGL 296

Query: 680 LNIDGAVTSGLYVTGKDNYGSISLGNI 706
L + + G +S ++
Sbjct: 297 LYLTAVEELSRIFDTQRVAGILSTASL 323



Score = 39.8 bits (93), Expect = 3e-05
Identities = 11/34 (32%), Positives = 18/34 (52%), Gaps = 1/34 (2%)

Query: 129 HDWVKTKGAWDKGYKGQGKVVAVIDTGIDPAHQS 162
+ ++ W++ G+G VAV+DTG D H
Sbjct: 26 VEMIQAPAVWNQTR-GRGVKVAVLDTGCDADHPD 58


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0353BINARYTOXINA382e-05 Clostridial binary toxin A signature.
		>BINARYTOXINA#Clostridial binary toxin A signature.

Length = 454

Score = 38.5 bits (89), Expect = 2e-05
Identities = 42/170 (24%), Positives = 70/170 (41%), Gaps = 27/170 (15%)

Query: 93 INTSLDKTKGELSQLTPELKDQVAQLDAATHRLVIPWNIVVYRYVYETFLRDIGVSHADL 152
IN L + G L+ PEL +V ++ A IP N++VYR G L
Sbjct: 295 INNYL-ISNGPLNNPNPELDSKVNNIENALKLTPIPSNLIVYRRS--------GPQEFGL 345

Query: 153 TSYYRNHQFDPHILCKIK---------LGTRYTKHSFMSTT--ALKNGAMTHRPVEVRIC 201
T + F+ KI+ G T +F+ST+ ++ A R + +RI
Sbjct: 346 TLTSPEYDFN-----KIENIDAFKEKWEGKVITYPNFISTSIGSVNMSAFAKRKIILRIN 400

Query: 202 VKKGAKAAFVEPYSAVPSEVELLFPRGCQLEV--VGAYVSQDHKKLHIEA 249
+ K + A++ E E+L G + ++ V +Y KL ++A
Sbjct: 401 IPKDSPGAYLSAIPGYAGEYEVLLNHGSKFKINKVDSYKDGTVTKLILDA 450


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0357GPOSANCHOR280.040 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 27.7 bits (61), Expect = 0.040
Identities = 12/66 (18%), Positives = 19/66 (28%), Gaps = 1/66 (1%)

Query: 162 KLKDSQTLKKEKEKKERQLAEEKQIEEERKHVEQKQLEESM-LKQIREEDHKPWHQRLSE 220
L+ + K + L EK RK +K LE +M K +
Sbjct: 128 ALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAA 187

Query: 221 SIQQDQ 226
+
Sbjct: 188 LEARQA 193


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0361DHBDHDRGNASE1001e-27 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase sig...
		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

signature.
Length = 261

Score = 100 bits (249), Expect = 1e-27
Identities = 68/252 (26%), Positives = 111/252 (44%), Gaps = 24/252 (9%)

Query: 3 KVVLVTGCASGIGYAQARYFLSQGYHVYGVDKSDKPDLNGNFHFIKLDLSSELSPL---- 58
K+ +TG A GIG A AR SQG H+ VD + + +E P
Sbjct: 9 KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVRD 68

Query: 59 -----------FKVVPSVDILCNTAGILDAYKPLLDVSDEEVEHLFDINFFATVKLTRHY 107
+ + +DIL N AG+L + +SDEE E F +N +R
Sbjct: 69 SAAIDEITARIEREMGPIDILVNVAGVLRP-GLIHSLSDEEWEATFSVNSTGVFNASRSV 127

Query: 108 LRHMVEKQSGVIINMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAKDQIHIFGIAP 167
++M++++SG I+ + S + + AY SSK A FT+ L L+ A+ I ++P
Sbjct: 128 SKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSP 187

Query: 168 GAVKTAM-----TASDFEP---GGLADWVARETPIGRWTEPSEVAELTGFLASGKTRSMQ 219
G+ +T M + G + P+ + +PS++A+ FL SG+ +
Sbjct: 188 GSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQAGHIT 247

Query: 220 GEIVKIDGGWTL 231
+ +DGG TL
Sbjct: 248 MHNLCVDGGATL 259


5MGAS10750_Spy0375MGAS10750_Spy0414Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy03753221.940353membrane protein
MGAS10750_Spy03763212.83247050S ribosomal protein L11
MGAS10750_Spy03773192.39237950S ribosomal protein L1
MGAS10750_Spy03780163.293357uridylate kinase
MGAS10750_Spy0379-1152.778895ribosome recycling factor
MGAS10750_Spy03800153.045689S1 RNA binding domain
MGAS10750_Spy03810153.159817methionine sulfoxide reductase A
MGAS10750_Spy03820152.906216hypothetical protein
MGAS10750_Spy0383-1152.796857Surface antigen
MGAS10750_Spy03840181.889870myosin-cross-reactive antigen
MGAS10750_Spy0385-2191.839960PhoH protein
MGAS10750_Spy0386-2160.423676uracil DNA glycosylase
MGAS10750_Spy0387-216-0.728934metalloprotease
MGAS10750_Spy0388-118-2.007414Diacylglycerol kinase
MGAS10750_Spy0389320-2.944325GTP-binding protein Era
MGAS10750_Spy0390522-4.204335phosphohydrolase
MGAS10750_Spy0391320-4.822438hypothetical protein
MGAS10750_Spy0392320-4.235041Response regulator FasA
MGAS10750_Spy0393318-3.076621bacteriocin ABC transporter
MGAS10750_Spy0394319-1.506781bacteriocin ABC transporter
MGAS10750_Spy03954210.065115Bacteriocin processing peptidase
MGAS10750_Spy0396221-0.075909hypothetical protein
MGAS10750_Spy0397221-0.353805hypothetical protein
MGAS10750_Spy0398322-1.782043hypothetical protein
MGAS10750_Spy0399322-5.379981hypothetical protein
MGAS10750_Spy0400321-6.595872transposase
MGAS10750_Spy0401220-6.343642transposase
MGAS10750_Spy0402119-7.082879transposase
MGAS10750_Spy0403117-5.776498Response regulator FasA
MGAS10750_Spy0404016-5.279313Sensory transduction protein kinase
MGAS10750_Spy0405018-3.384876hypothetical protein
MGAS10750_Spy0406-118-2.525139Bacteriocin export accessory protein
MGAS10750_Spy0407117-2.782695Bacteriocin export accessory protein
MGAS10750_Spy0408220-3.209016bacteriocin ABC transporter
MGAS10750_Spy0409628-3.798736Bacteriocin
MGAS10750_Spy0410522-1.379487hypothetical protein
MGAS10750_Spy0411321-1.059187hypothetical protein
MGAS10750_Spy0412421-1.696942hypothetical protein
MGAS10750_Spy0413220-0.744971hypothetical protein
MGAS10750_Spy04142230.929396hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0383IGASERPTASE340.001 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 34.3 bits (78), Expect = 0.001
Identities = 40/205 (19%), Positives = 71/205 (34%), Gaps = 15/205 (7%)

Query: 91 ANYNQHGQATTLTVQAPASSPASVSHVPSSEPLPQASATSQSTVPMAPSATP--SDVPTT 148
+N + + V PA + S + +E Q S T + A T +V
Sbjct: 1012 SNNEEIARVDEAPVPPPAPATPSETTETVAENSKQESKTVEKNEQDATETTAQNREVAKE 1071

Query: 149 PFASAKPDSSVTASSELTSSTNDVSTELSSESQKQPEVPQEAVPTPKAAE----TTEVEP 204
++ K ++ ++ S T + T + E+ + + V T K E T++V P
Sbjct: 1072 AKSNVKANTQTNEVAQSGSETKETQTTETKETATVEKEEKAKVETEKTQEVPKVTSQVSP 1131

Query: 205 KTDISEDSTSANRPVPNESASEEVSSAAPAQAPAEKEETSQMLTAPAAQKAVADTTSVAT 264
K + SE P + + P + T+ PA + + V
Sbjct: 1132 KQEQSETVQPQAEPARENDPTVN------IKEPQSQTNTTADTEQPAKETSSNVEQPVTE 1185

Query: 265 SNGLSYAPNHAYNPMN---AGLQPQ 286
S ++ + NP N A QP
Sbjct: 1186 STTVNTGNSVVENPENTTPATTQPT 1210



Score = 33.1 bits (75), Expect = 0.002
Identities = 30/172 (17%), Positives = 55/172 (31%), Gaps = 14/172 (8%)

Query: 98 QATTLTVQAPASSPASVSHVPSSEPLPQASATSQSTVPMAPSATPSDVPTTPFASAKPDS 157
+ +T Q S + P +EP + T P + + T +D P +
Sbjct: 1121 EVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQTNTTADT-EQPAKETSSNV 1179

Query: 158 SVTASSELTSSTNDVSTELSSESQKQPEVPQEAVPTPKAAETTEVEPKTDISEDSTSANR 217
+ T +T + E PE A P + +PK + R
Sbjct: 1180 EQPVTESTTVNTGNSVVE-------NPENTTPATTQPTVNSESSNKPKN----RHRRSVR 1228

Query: 218 PVPNESASEEVSSAAPAQAPAEKEETSQMLTAPAAQKAVADTTSVATSNGLS 269
VP E ++++ ++ + + T A A VA + G +
Sbjct: 1229 SVP--HNVEPATTSSNDRSTVALCDLTSTNTNAVLSDARAKAQFVALNVGKA 1278


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0389TCRTETOQM320.003 Tetracycline resistance protein TetO/TetQ/TetM family ...
		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

signature.
Length = 639

Score = 32.1 bits (73), Expect = 0.003
Identities = 31/138 (22%), Positives = 59/138 (42%), Gaps = 17/138 (12%)

Query: 1 MFKSGFVAILGRPNVGKSTFLNHVMGQKIAIMSDKAQTTRNKIMGIYTTETEQIVFIDTP 60
++ SG + LG + G + N ++ ++ I T+ + E ++ IDTP
Sbjct: 24 LYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGITS-------FQWENTKVNIIDTP 76

Query: 61 GIHKPKTALGDFMVESAYSTLREVETVLFMVPADEKRGKGDDMIIERLKAAKIPVILVIN 120
G H DF+ E Y +L ++ + ++ A + ++ L+ IP I IN
Sbjct: 77 G-HM------DFLAE-VYRSLSVLDGAILLISAKDGVQAQTRILFHALRKMGIPTIFFIN 128

Query: 121 KIDK--VHPDQLLAQIDD 136
KID+ + + I +
Sbjct: 129 KIDQNGIDLSTVYQDIKE 146


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0403HTHFIS383e-05 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 37.5 bits (87), Expect = 3e-05
Identities = 23/137 (16%), Positives = 49/137 (35%), Gaps = 10/137 (7%)

Query: 3 IFVLEDDFLHQTRIGKIIYKILTDNKLEVNHLEVYGKPNQLLEDISERGRHQLFFLDIDI 62
I V +DD I ++ + L+ +V + L I+ G L D+ +
Sbjct: 6 ILVADDD----AAIRTVLNQALSRAGYDV---RITSNAATLWRWIA-AGDGDLVVTDVVM 57

Query: 63 KGEDKKGMEIAVEIRNRDPHAVIVFVTTHSEFMPVSFQYQVSALDFIDKELPEELFSHRI 122
E+ ++ I+ P ++ ++ + FM + A D++ K I
Sbjct: 58 PDEN--AFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGII 115

Query: 123 EKAITYVQDNQGKTLAE 139
+A+ + K +
Sbjct: 116 GRALAEPKRRPSKLEDD 132


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0406RTXTOXIND397e-06 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 39.0 bits (91), Expect = 7e-06
Identities = 17/139 (12%), Positives = 52/139 (37%), Gaps = 4/139 (2%)

Query: 22 RIKIDILKTQFLQNASQQLTTVENQITELKDQIEQANIQLKNNIIIAPETGTIHLNSEFE 81
+ + ++ F +L + I L ++ + + + ++I AP + +
Sbjct: 286 KEEYQLVTQLFKNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHT 345

Query: 82 GKSLIPNGSEVAQIYPDIQKIKEVFITYYVTSEHVSLLKEKQGVRLSLEKV-GNQTLTIN 140
++ + I P+ ++ +T V ++ + + Q + +E + +
Sbjct: 346 EGGVVTTAETLMVIVPEDDTLE---VTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLV 402

Query: 141 GTIQTIDKSATKTDQGNLF 159
G ++ I+ A + + L
Sbjct: 403 GKVKNINLDAIEDQRLGLV 421


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0407RTXTOXIND446e-08 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 44.0 bits (104), Expect = 6e-08
Identities = 24/103 (23%), Positives = 50/103 (48%), Gaps = 9/103 (8%)

Query: 34 VLLVSFLVLF---SLFAKKEITITSQGEMTP---TKVIASVQSTSDHTIVVNNLKNNKFI 87
++ FLV+ S+ + EI T+ G++T +K I ++++ I+V K + +
Sbjct: 62 YFIMGFLVIAFILSVLGQVEIVATANGKLTHSGRSKEIKPIENSIVKEIIV---KEGESV 118

Query: 88 KKGDVIIQYSKTMENSQKKALEKQLATLNKQKNGLQILKTSLE 130
+KGDV+++ + + + L ++ QIL S+E
Sbjct: 119 RKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIE 161


6MGAS10750_Spy0447MGAS10750_Spy0487Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy04472164.299045dihydroxyacetone kinase subunit DhaK
MGAS10750_Spy04481173.025769dihydroxyacetone kinase
MGAS10750_Spy04491141.851495phosphotransferase mannnose-specific family
MGAS10750_Spy0450-1131.596870glycerol uptake facilitator protein
MGAS10750_Spy0451-2120.558233hypothetical protein
MGAS10750_Spy0452-1110.129335acetyl-CoA acetyltransferase
MGAS10750_Spy0453-211-1.158983Long-chain-fatty-acid--CoA ligase
MGAS10750_Spy0454013-1.509215hypothetical protein
MGAS10750_Spy0455012-2.079811two-component response regulator VicR
MGAS10750_Spy0456013-3.341274two-component sensor histidine kinase VicK
MGAS10750_Spy0457015-4.732635Zn-dependent hydrolase
MGAS10750_Spy0458117-5.173167ribonuclease III
MGAS10750_Spy0459118-5.854265chromosome partition protein smc
MGAS10750_Spy0460324-8.850317transcriptional regulator
MGAS10750_Spy0461329-9.374785shikimate 5-dehydrogenase
MGAS10750_Spy0462327-9.245204hypothetical protein
MGAS10750_Spy0463425-8.884468hypothetical protein
MGAS10750_Spy0464326-9.324235hypothetical protein
MGAS10750_Spy0465227-9.436648S-adenosylmethionine synthetase
MGAS10750_Spy0466226-9.498365hypothetical protein
MGAS10750_Spy0467221-7.979496cell wall biogenesis glycosyltransferase
MGAS10750_Spy0468320-6.632341hypothetical protein
MGAS10750_Spy0469219-6.140571UDP-glucose 6-dehydrogenase
MGAS10750_Spy0470218-3.787901Macrolide-efflux protein
MGAS10750_Spy0471322-1.838811transcriptional regulator
MGAS10750_Spy0472322-1.292109chromosome segregation ATPase
MGAS10750_Spy0473223-1.220162chromosome segregation ATPase
MGAS10750_Spy04743260.305064hypothetical protein
MGAS10750_Spy04763271.330703hypothetical protein
MGAS10750_Spy0475328-0.019879plasmid stabilization system antitoxin protein
MGAS10750_Spy0477529-1.910438plasmid stabilization system toxin protein
MGAS10750_Spy0478629-3.900551hypothetical protein
MGAS10750_Spy0479629-4.632611Portal protein
MGAS10750_Spy0480930-6.252291hypothetical protein
MGAS10750_Spy0481832-7.644386hypothetical protein
MGAS10750_Spy0482832-8.147310asparagine synthetase A
MGAS10750_Spy0483832-9.358732hypothetical protein
MGAS10750_Spy0484729-8.659120hypothetical protein
MGAS10750_Spy0485326-7.822588Microcin C7 self-immunity protein mccF
MGAS10750_Spy0486-126-8.267115hypothetical protein
MGAS10750_Spy0487-121-5.356251hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0455HTHFIS921e-23 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 91.8 bits (228), Expect = 1e-23
Identities = 29/133 (21%), Positives = 65/133 (48%), Gaps = 1/133 (0%)

Query: 3 KILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLE 62
IL+ DD+ I ++ L++ GYD+ + DL++ D+++P+ + +
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64

Query: 63 VAKEIRKT-SHVPIIMLSAKDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTET 121
+ I+K +P++++SA+++ + E GA DY+ KPF EL+ + L +
Sbjct: 65 LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKR 124

Query: 122 IETAVAEENASSG 134
+ + +++
Sbjct: 125 RPSKLEDDSQDGM 137


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0456PF06580445e-07 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 44.5 bits (105), Expect = 5e-07
Identities = 30/187 (16%), Positives = 72/187 (38%), Gaps = 34/187 (18%)

Query: 253 DETNRMMRMISDLL--NLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVY 310
+ M+ +S+L+ +L + + LA E+T +++ +F +++ ++
Sbjct: 191 TKAREMLTSLSELMRYSLRYSNARQVSLADELTVVDSYLQLASIQF---EDRLQFENQIN 247

Query: 311 EIVRDYPITSVWLEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQG 370
+ D + + ++ ++EN + + I P GGKI ++ + + + + + G
Sbjct: 248 PAIMDVQVPPMLVQT-------LVENGIKHGIAQLPQGGKILLKGTKDNGTVTLEVENTG 300

Query: 371 LGIPKTDLPLIFDRFYRVDKARSRAQGGTGLGLAIAKEIIKQHHGF---IWAKSDYGKGS 427
K + TG GL +E ++ +G I GK
Sbjct: 301 SLALKNT------------------KESTGTGLQNVRERLQMLYGTEAQIKLSEKQGKV- 341

Query: 428 TFTIVLP 434
+++P
Sbjct: 342 NAMVLIP 348


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0459GPOSANCHOR491e-07 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 48.5 bits (115), Expect = 1e-07
Identities = 48/313 (15%), Positives = 95/313 (30%), Gaps = 10/313 (3%)

Query: 209 AKVAKQFLELDANRKQLQLDILVKDIDIAQERQTKDTEALAALQQDLASYYAKRQSMEED 268
+ VA + + Q + D + + + + + + AL+ + + +E
Sbjct: 41 SAVATRSQTDTLEKVQERADKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEK 100

Query: 269 YQKFKQKKQVLSQESDQTQTTLLELTKLIADLEKQIELVKLESGQ---EAEKKAEAKKHL 325
+K + + + + + +L K + + E A K L
Sbjct: 101 LRKNDKSLSEKASKIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADL 160

Query: 326 EQLQEQLDGFQAEEKQRTEQLLHIDQQLCDVKQQLNELSNALERFSSDPDQLMETLREEF 385
E+ E F + + + L L + +L + FS+ ++TL E
Sbjct: 161 EKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEK 220

Query: 386 VLLMQKEAALSNQLTALKAHLDKEKQARQHKAQEYQLLVTKLDQLNDESQKAQAHYKAQK 445
L ++A L L + + E L + +L + A A
Sbjct: 221 AALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADS 280

Query: 446 EQVEMLLQNYQEGDKRVQELERDYQLNQERLFDLLDQ-------KKGKEARKASLESIQK 498
+++ L + +LE Q+ L KK EA LE K
Sbjct: 281 AKIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNK 340

Query: 499 SHSQFYAGVRAVL 511
+R L
Sbjct: 341 ISEASRQSLRRDL 353



Score = 30.4 bits (68), Expect = 0.044
Identities = 38/243 (15%), Positives = 88/243 (36%), Gaps = 18/243 (7%)

Query: 169 KYKTRKKETQIKLNQTQDNLDRLEDIIYELDTQLAPLEKQAKVAKQFLELDANRKQLQLD 228
+ + + LE L+ + A LEK + A F ++
Sbjct: 229 DLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTA----DSAKIK 284

Query: 229 ILVKDIDIAQERQTKDTEALAALQ-------QDLASYYAKRQSMEEDYQKFKQKKQVLSQ 281
L + + + L +DL + ++ +E ++QK +++ ++
Sbjct: 285 TLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEA 344

Query: 282 ESDQTQTTLLELTKLIADLEKQIELVKLESGQEAEKKAEAKKHLEQLQEQLDGFQAEEKQ 341
+ L + LE + + ++ E+ ++ + L+ LD + +KQ
Sbjct: 345 SRQSLRRDLDASREAKKQLEAEHQKLE-------EQNKISEASRQSLRRDLDASREAKKQ 397

Query: 342 RTEQLLHIDQQLCDVKQQLNELSNALERFSSDPDQLMETLREEFVLLMQKEAALSNQLTA 401
+ L + +L +++ EL + + + +L L E L +K A + +L
Sbjct: 398 VEKALEEANSKLAALEKLNKELEESKKLTEKEKAELQAKLEAEAKALKEKLAKQAEELAK 457

Query: 402 LKA 404
L+A
Sbjct: 458 LRA 460


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0470TCRTETA384e-05 Tetracycline resistance protein signature.
		>TCRTETA#Tetracycline resistance protein signature.

Length = 399

Score = 38.3 bits (89), Expect = 4e-05
Identities = 28/141 (19%), Positives = 59/141 (41%), Gaps = 13/141 (9%)

Query: 52 SVIGVLFNLFGGVIADSFKR----KKIIITTNILCGTACLVLSFLTKEQWLVYAIVLTNV 107
+ G+L +L +I ++ ++ I GT ++L+F T W+ + I+ V
Sbjct: 253 AAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFAT-RGWMAFPIM---V 308

Query: 108 ILAFMSAFSSPSYKAFTKEIVKKDSISQLNSLLETTSTVIKVTVPMVAIFLYKLLGIHGV 167
+LA P+ +A V ++ QL L +++ + P++ +Y +
Sbjct: 309 LLAS-GGIGMPALQAMLSRQVDEERQGQLQGSLAALTSLTSIVGPLLFTAIYA----ASI 363

Query: 168 LLLDGLSFLIAALLISFILPV 188
+G +++ A L LP
Sbjct: 364 TTWNGWAWIAGAALYLLCLPA 384


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0484FRAGILYSIN250.021 Fragilysin metallopeptidase (M10C) enterotoxin signat...
		>FRAGILYSIN#Fragilysin metallopeptidase (M10C) enterotoxin

signature.
Length = 405

Score = 25.4 bits (55), Expect = 0.021
Identities = 10/45 (22%), Positives = 18/45 (40%), Gaps = 5/45 (11%)

Query: 9 EIGHIFPSNLNKEEKSRVYSWAEKLHQILQLNHITTHTEFRIGRN 53
E+GHI + K +Y+ L+H++ I +N
Sbjct: 357 ELGHILGAEHTDNSKDLMYATFTG-----YLSHLSEKNMDIIAKN 396


7MGAS10750_Spy0559MGAS10750_Spy0616Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy0559017-3.738258hypothetical protein
MGAS10750_Spy0560020-4.759535Site-specific recombinase
MGAS10750_Spy0561-120-3.344223phage protein
MGAS10750_Spy0562222-2.726755phage transcriptional repressor
MGAS10750_Spy0563326-3.822623phage protein
MGAS10750_Spy0564225-4.123453phage protein
MGAS10750_Spy0565228-2.685034phage protein
MGAS10750_Spy0566229-2.773591phage protein
MGAS10750_Spy0567227-3.699062hypothetical protein
MGAS10750_Spy0568529-4.732815phage protein
MGAS10750_Spy0569328-3.767083hypothetical protein
MGAS10750_Spy0570126-2.333117phage protein
MGAS10750_Spy0571225-2.400088phage protein
MGAS10750_Spy0572021-1.631816hypothetical protein
MGAS10750_Spy0573118-1.211427phage protein
MGAS10750_Spy0574117-1.375937phage protein
MGAS10750_Spy0575116-1.114341phage DNA/RNA helicase
MGAS10750_Spy0576218-1.568572phage protein
MGAS10750_Spy0577221-1.351260phage protein
MGAS10750_Spy0578323-1.910613DNA primase
MGAS10750_Spy0579325-4.244033phage protein
MGAS10750_Spy0580531-3.205782phage protein
MGAS10750_Spy0581730-3.048244phage protein
MGAS10750_Spy0582527-2.896697phage protein
MGAS10750_Spy0583325-2.740254phage protein
MGAS10750_Spy0584121-2.298976phage protein
MGAS10750_Spy0585120-1.162746phage protein
MGAS10750_Spy0586119-0.773465phage protein
MGAS10750_Spy0587320-1.618445Methyltransferase
MGAS10750_Spy0588220-1.461316Adenine-specific methyltransferase
MGAS10750_Spy0589423-1.491586phage protein
MGAS10750_Spy0590524-1.624011phage protein
MGAS10750_Spy0591526-1.855618phage protein
MGAS10750_Spy0592524-2.480606phage protein
MGAS10750_Spy0593118-1.449140phage protein
MGAS10750_Spy0594218-1.821210phage protein
MGAS10750_Spy0595218-1.584824phage endonuclease
MGAS10750_Spy0596018-1.229877phage terminase small subunit
MGAS10750_Spy0597016-0.983073hypothetical protein
MGAS10750_Spy0598014-0.673541Terminase large subunit
MGAS10750_Spy0599317-0.489789phage protein
MGAS10750_Spy0600217-0.052146phage protein
MGAS10750_Spy0601117-0.354756Portal protein
MGAS10750_Spy0602216-0.375202ATP-dependent endopeptidase clp proteolytic
MGAS10750_Spy0603318-1.334197phage protein
MGAS10750_Spy0604123-1.123299phage protein
MGAS10750_Spy0605219-1.443984phage protein
MGAS10750_Spy0606219-1.777459phage protein
MGAS10750_Spy06073151.597902phage protein
MGAS10750_Spy06084151.753275phage protein
MGAS10750_Spy06093182.670688Major tail protein
MGAS10750_Spy06103172.624212phage protein
MGAS10750_Spy06113203.378543phage protein
MGAS10750_Spy06123203.176291phage protein
MGAS10750_Spy06134263.247850phage protein
MGAS10750_Spy06144262.885548phage endopeptidase
MGAS10750_Spy06154233.234769Hyaluronoglucosaminidase
MGAS10750_Spy06163221.842186phage infection protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0586PF06580260.021 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 26.0 bits (57), Expect = 0.021
Identities = 7/45 (15%), Positives = 19/45 (42%)

Query: 29 LFLAIAIFGMMVTVSYFSYRDARQYYESQITGLRTQLSRTQKQLK 73
+ + + M ++ YF + + Y +++I + + QL
Sbjct: 120 IIFNVVVVTFMWSLLYFGWHFFKNYKQAEIDQWKMASMAQEAQLM 164


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0592PRPHPHLPASEC300.016 Prokaryotic zinc-dependent phospholipase C signature.
		>PRPHPHLPASEC#Prokaryotic zinc-dependent phospholipase C signature.

Length = 398

Score = 29.6 bits (66), Expect = 0.016
Identities = 32/180 (17%), Positives = 65/180 (36%), Gaps = 14/180 (7%)

Query: 109 NKIRQKEPKSVDDNLKLLVNSFGNELSSYLYGADWSDTKYDLAVEIINKHDVFSGYKQTE 168
N + + EP+SV NL++L +EL D+ YDL + D + + +
Sbjct: 52 NDLSKNEPESVRKNLEIL-KENMHELQLGSTYPDYDKNAYDLYQDHFWDPDTDNNFSKDN 110

Query: 169 TYKKADKPYDEGELEKNKKLTQLEQLQQLGRLQQL-----EQLQQLGRLQQLEQLQQLGR 223
++ A D GE + K Q G +Q E + G + +
Sbjct: 111 SWYLAYSIPDTGESQIRKFSALARYEWQRGNYKQATFYLGEAMHYFGDIDTPYHPANVTA 170

Query: 224 LQQLGRLEQLEPTNYSYEAFSDIEDAIFYLDPPYENTTQKSYKGDFNSQAFYDWAFGMSK 283
+ G ++ +E F++ + ++ T + Y ++ F W+ ++
Sbjct: 171 VDSAGHVK--------FETFAEERKEQYKINTAGCKTNEDFYADILKNKDFNAWSKEYAR 222


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0614SSPAMPROTEIN290.036 Salmonella surface presentation of antigen gene typ...
		>SSPAMPROTEIN#Salmonella surface presentation of antigen gene type M

signature.
Length = 147

Score = 28.9 bits (64), Expect = 0.036
Identities = 23/65 (35%), Positives = 29/65 (44%), Gaps = 6/65 (9%)

Query: 387 ERINALENNQKVITNNQKQFELNLPKYLNDINGKRVWYEKPDDNIEHKIGDYWFEKNGKY 446
E I AL Q ++ K EL + + I KR EK + + K YW K G Y
Sbjct: 66 EEIYALLRKQSIVRRQIKDLELQIIQ----IQEKRSELEKKREEFQEK-SKYWLRKEGNY 120

Query: 447 QRTWI 451
QR WI
Sbjct: 121 QR-WI 124


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0615PF072125630.0 Hyaluronoglucosaminidase
		>PF07212#Hyaluronoglucosaminidase

Length = 336

Score = 563 bits (1452), Expect = 0.0
Identities = 336/336 (100%), Positives = 336/336 (100%)

Query: 1 MTETIPLRVQFKRMTAEEWTRSDVILLESEIGFETDTGYAKFGDGKNQFSKLKYLNKPDL 60
MTETIPLRVQFKRMTAEEWTRSDVILLESEIGFETDTGYAKFGDGKNQFSKLKYLNKPDL
Sbjct: 1 MTETIPLRVQFKRMTAEEWTRSDVILLESEIGFETDTGYAKFGDGKNQFSKLKYLNKPDL 60

Query: 61 GAFAQKEETNSKITKLESSKADKNAVYLKAESKIELDKKLNLKGGVMTGQLQFKPNKSGI 120
GAFAQKEETNSKITKLESSKADKNAVYLKAESKIELDKKLNLKGGVMTGQLQFKPNKSGI
Sbjct: 61 GAFAQKEETNSKITKLESSKADKNAVYLKAESKIELDKKLNLKGGVMTGQLQFKPNKSGI 120

Query: 121 KPSSSVGGAINIDMSKSEGAGVVVYSNNDTSDGPLMSLRTGKETFNQSALFVDYSGKTNA 180
KPSSSVGGAINIDMSKSEGAGVVVYSNNDTSDGPLMSLRTGKETFNQSALFVDYSGKTNA
Sbjct: 121 KPSSSVGGAINIDMSKSEGAGVVVYSNNDTSDGPLMSLRTGKETFNQSALFVDYSGKTNA 180

Query: 181 VNIAMRQPTTPNFSSALNITSGNENGSAMQIRGVEKALGTLKITHENPNVEANYDENAAA 240
VNIAMRQPTTPNFSSALNITSGNENGSAMQIRGVEKALGTLKITHENPNVEANYDENAAA
Sbjct: 181 VNIAMRQPTTPNFSSALNITSGNENGSAMQIRGVEKALGTLKITHENPNVEANYDENAAA 240

Query: 241 LSIDIVKKQKGGKGTAAQGIYINSTSGTTGKLLRIRNLGDDKFYVKHDGGFYAKKTSQID 300
LSIDIVKKQKGGKGTAAQGIYINSTSGTTGKLLRIRNLGDDKFYVKHDGGFYAKKTSQID
Sbjct: 241 LSIDIVKKQKGGKGTAAQGIYINSTSGTTGKLLRIRNLGDDKFYVKHDGGFYAKKTSQID 300

Query: 301 GNLKLKNPTADDHAATKAYVDSEVKKLKALLMDKQV 336
GNLKLKNPTADDHAATKAYVDSEVKKLKALLMDKQV
Sbjct: 301 GNLKLKNPTADDHAATKAYVDSEVKKLKALLMDKQV 336


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0616RTXTOXIND340.003 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 33.6 bits (77), Expect = 0.003
Identities = 27/145 (18%), Positives = 51/145 (35%), Gaps = 21/145 (14%)

Query: 158 RLSSSYQSGINGLKAQLANDKI---GLQAEIQATAQGLSQKYDNELRQLSAKITTTSSGT 214
RL+S + + + Q ++ +AE T +Y+N R +++ SS
Sbjct: 186 RLTSLIKEQFSTWQNQKYQKELNLDKKRAERL-TVLARINRYENLSRVEKSRLDDFSSLL 244

Query: 215 TEAYESKLAGLRAEFTRSNQGMRIELESQISGLRAVQQSTASQISQEIRDRTGAVSRVQQ 274
+ +K A L E E++ + SQ+ Q + A Q
Sbjct: 245 HKQAIAKHAVL-------------EQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQL 291

Query: 275 DLESYQR----RLQDAEDNYSSLTH 295
+ ++ +L+ DN LT
Sbjct: 292 VTQLFKNEILDKLRQTTDNIGLLTL 316


8MGAS10750_Spy0634MGAS10750_Spy0669Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy06342180.39258350S ribosomal protein L19
MGAS10750_Spy06352150.174523*DNA gyrase subunit B
MGAS10750_Spy06363160.255689DNA gyrase subunit B
MGAS10750_Spy0637419-0.162662septation ring formation regulator EzrA
MGAS10750_Spy06384230.488336hypothetical protein
MGAS10750_Spy06393240.778591phosphopyruvate hydratase
MGAS10750_Spy0640315-0.283356transposase
MGAS10750_Spy0641214-0.819006transposase
MGAS10750_Spy0642112-1.057878transcriptional regulator
MGAS10750_Spy0643315-1.596960Extracellular matrix binding protein
MGAS10750_Spy0644119-3.577393streptolysin S precursor
MGAS10750_Spy0645019-3.624425streptolysin S biosynthesis protein SagB
MGAS10750_Spy0646-119-3.973229streptolysin S biosynthesis protein SagC
MGAS10750_Spy0647019-4.413538streptolysin S biosynthesis protein SagD
MGAS10750_Spy0648-115-3.476070streptolysin S self-immunity protein SagE
MGAS10750_Spy0649-114-3.469548streptolysin S biosynthesis protein SagF
MGAS10750_Spy0650-213-2.236875streptolysin S export ATP-binding protein SagG
MGAS10750_Spy0651-213-2.026918streptolysin S export transmembrane protein
MGAS10750_Spy0652-212-0.969862streptolysin S export transmembrane protein
MGAS10750_Spy0653-2111.047528endonuclease/exonuclease/phosphatase family
MGAS10750_Spy06540152.184448hypothetical protein
MGAS10750_Spy0655-1152.691594NAD-dependent DNA ligase LigA
MGAS10750_Spy06560172.753105lipid kinase
MGAS10750_Spy06572212.757395transposase
MGAS10750_Spy06580172.428429transposase
MGAS10750_Spy06590190.131639F0F1 ATP synthase subunit C
MGAS10750_Spy06600191.140537F0F1 ATP synthase subunit A
MGAS10750_Spy06612211.520697F0F1 ATP synthase subunit B
MGAS10750_Spy06621191.433589F0F1 ATP synthase subunit delta
MGAS10750_Spy06631182.270525F0F1 ATP synthase subunit alpha
MGAS10750_Spy06640161.559557F0F1 ATP synthase subunit gamma
MGAS10750_Spy0665-1132.288203F0F1 ATP synthase subunit beta
MGAS10750_Spy0666-1131.726859F0F1 ATP synthase subunit epsilon
MGAS10750_Spy0667-1131.936927hypothetical protein
MGAS10750_Spy06680122.780923UDP-N-acetylglucosamine
MGAS10750_Spy06692142.701474EpuA protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0634FLGMOTORFLIM260.043 Flagellar motor switch protein FliM signature.
		>FLGMOTORFLIM#Flagellar motor switch protein FliM signature.

Length = 344

Score = 26.0 bits (57), Expect = 0.043
Identities = 16/63 (25%), Positives = 25/63 (39%), Gaps = 8/63 (12%)

Query: 3 PLIQSLTEGQLR-SDIPNFRPGDTVRVHAKVVE-------GTRERIQIFEGVVISRKGQG 54
++ + +L DI R GD +R+H V G R++ GVV +
Sbjct: 260 DVVAEVGSLRLSVRDILGLRVGDIIRLHDTHVGDPFVLSIGNRKKFLCQPGVVGKKIAAQ 319

Query: 55 ISE 57
I E
Sbjct: 320 ILE 322


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0642PF082802474e-78 M protein trans-acting positive regulator
		>PF08280#M protein trans-acting positive regulator

Length = 530

Score = 247 bits (633), Expect = 4e-78
Identities = 130/442 (29%), Positives = 224/442 (50%), Gaps = 7/442 (1%)

Query: 1 MLDVSEVSIDQLCQETELKKQRVYNLLIEMIKDLEDTLTLTICDDTVSIPYKTYQLKMPY 60
S + I ++ ++T L ++ + E+ D+L++TI +S + T+ K Y
Sbjct: 53 FFKTSSLPITEVAEKTGLTFLQLNHYCEELNAFFPDSLSMTIQKRMISCQF-THPSKETY 111

Query: 61 FKKLYQTSIFLKMLCFLIE--PGELSLHDFIKREYISQATAYRIRTNCRKYLKKVGLNVR 118
+LY +S L++L FLI+ L DF + ++S ++AYR+R L+ L +
Sbjct: 112 LYQLYASSNVLQLLAFLIKNGSHSRPLTDFARSHFLSNSSAYRMREALIPLLRNFELKLS 171

Query: 119 QNHVVGPEYRIRFLIALLHYQFGMTIYDFDKTSMNKVVSLIINSNQAITLNDASKAPYEF 178
+N +VG EYRIR+LIALL+ +FG+ +YD + N + S + +S+ L + F
Sbjct: 172 KNKIVGEEYRIRYLIALLYSKFGIKVYDLTQQDKNIIHSFLSHSS--THLKTSPWLSESF 229

Query: 179 SYFAILISLIWKRQHGNLGIPQTDAFKHLKKLSIYHDIKMTSQEIIGKWYHPDLTDEDLD 238
S++ IL++L WKR ++ IPQT F+ LKKL +Y +K +S++II + + + DLD
Sbjct: 230 SFYDILLALSWKRHQFSVTIPQTRIFQQLKKLFVYDSLKKSSRDIIETYCQLNFSAGDLD 289

Query: 239 YIFLCFCTTNNPFHKDKWTPKKVKELFELVMTKTNGKTLKASLRPLLGDNILNSLPFKRI 298
Y++L + T NN F +WTP+ +++ +L + L + LL + +
Sbjct: 290 YLYLIYITANNSFASLQWTPEHIRQCCQLFEENDTFRLLLNPIITLLPNLKEQKASLVKA 349

Query: 299 LVSFSRLFISNLQVLLPDIHLFHYLRRQQKRNKSFYNTLKTIVEEWMSAEGIVGKLPSYH 358
L+ FS+ F+ NLQ +P+ +LF + K N+ Y +LK IVEEWM+ L H
Sbjct: 350 LMFFSKSFLFNLQHFIPETNLF--VSPYYKGNQKLYTSLKLIVEEWMAKLPGKRYLNHKH 407

Query: 359 LLLFTIQLEELLKTYLPPIPVYLLTNNTAALDLMTNALSIYFPPAIATVMPVNVEIIPFK 418
LF +E++L+ PP+ V + +N L+T++ YF +
Sbjct: 408 FHLFCHYVEQILRNIQPPLVVVFVASNFINAHLLTDSFPRYFSDKSIDFHSYYLLQDNVY 467

Query: 419 DIVKEKQSVIIADRQYLNLIQH 440
I K ++I Q + + H
Sbjct: 468 QIPDLKPDLVITHSQLIPFVHH 489


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0643CHANLCOLICIN310.045 Channel forming colicin signature.
		>CHANLCOLICIN#Channel forming colicin signature.

Length = 522

Score = 30.8 bits (69), Expect = 0.045
Identities = 51/259 (19%), Positives = 97/259 (37%), Gaps = 7/259 (2%)

Query: 1070 KAYRPGEAVKARKEAAKADLEREAAKVR-EAIANDPTLTKADKAKQTEAVAKALKAAIAA 1128
+A + A A + AKA R+A R + I N+ A + +A A AA+ A
Sbjct: 66 QAEQAARAKAAAEAQAKAKANRDALTQRLKDIVNEALRHNASRTPSATELAHANNAAMQA 125

Query: 1129 VDKATTAEGINQELGKGITAINKAYRPGEAVKARKEAAKANLEKVAKETKALISGDRYLS 1188
D+ ++ K A KA++ E + E KA E+ K +A LS
Sbjct: 126 EDERLRLAKAEEKARKEAEAAEKAFQEAEQRRKEIEREKAETERQLKLAEAEEKRLAALS 185

Query: 1189 ETEKAVQKQAVEQALAKA---LGQVEAAKTVEAVKLAENLGTVAIRSAYVAGLAKDTDQA 1245
E KAV + ++ L+ A + +++ +L+ ++ +AG + QA
Sbjct: 186 EEAKAV--EIAQKKLSAAQSEVVKMDGEIKTLNSRLSSSIHARDAEMKTLAGKRNELAQA 243

Query: 1246 TAALNEAKQAAIEALKQAAAETLAKITTDAKLTEAQKAEQSENVSLALKTAIATVRSAQS 1305
+A E + + +A + +A + E + + + +
Sbjct: 244 SAKYKELDELVKKLSPRANDPLQNRPFFEATRRRVGAGKIREEKQKQVTASETRINRINA 303

Query: 1306 -IASVKEAIDKGITAIRAA 1323
I +++AI + A
Sbjct: 304 DITQIQKAISQVSNNRNAG 322


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0649TYPE3IMSPROT310.003 Type III secretion system inner membrane S protein ...
		>TYPE3IMSPROT#Type III secretion system inner membrane S protein

family signature.
Length = 354

Score = 31.3 bits (71), Expect = 0.003
Identities = 15/76 (19%), Positives = 32/76 (42%), Gaps = 1/76 (1%)

Query: 37 SYQDFLDVLLSLFQFVIIILVLFFYSATINLGEVLTFLTQTSWHWQILCYLVLYLMAIIE 96
S + ++ L S+ + V++ ++++ NL +L T L +L + +I
Sbjct: 133 SIKSLVEFLKSILKVVLLSILIWII-IKGNLVTLLQLPTCGIECITPLLGQILRQLMVIC 191

Query: 97 MTLLVLILIFDVLLQK 112
V+I I D +
Sbjct: 192 TVGFVVISIADYAFEY 207


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0652ABC2TRNSPORT320.004 ABC-2 type transport system membrane protein signat...
		>ABC2TRNSPORT#ABC-2 type transport system membrane protein

signature.
Length = 262

Score = 31.8 bits (72), Expect = 0.004
Identities = 23/117 (19%), Positives = 46/117 (39%), Gaps = 3/117 (2%)

Query: 255 FVPTSLLLIIFFLFSLLAIGF---GLLIGAITQNSQQSSQLANLIVMPTSMLAGCLWPLS 311
+ LL + +L + F G+++ A+ + L++ P L+G ++P+
Sbjct: 141 YTQWLSLLYALPVIALTGLAFASLGMVVTALAPSYDYFIFYQTLVITPILFLSGAVFPVD 200

Query: 312 ITPSYMQAIGKLLPQNWVLSAIAIFQSGGTLSQAWPHLLALMGTALALIIFSSLLLK 368
P Q + LP + + I G + H+ AL + S+ LL+
Sbjct: 201 QLPIVFQTAARFLPLSHSIDLIRPIMLGHPVVDVCQHVGALCIYIVIPFFLSTALLR 257


9MGAS10750_Spy0690MGAS10750_Spy0703Y        NNGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy0690-315-4.187379alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase
MGAS10750_Spy0691-317-5.574285alpha-L-Rha alpha-1,3-L-rhamnosyltransferase
MGAS10750_Spy0692-219-5.866333Polysaccharide export ABC transporter permease
MGAS10750_Spy0693-220-6.236847Polysaccharide export ATP-binding protein
MGAS10750_Spy0694-122-7.036474glycosyltransferase
MGAS10750_Spy0695021-7.465305alpha-L-Rha alpha-1,2-L-rhamnosyltransferase /
MGAS10750_Spy0696120-6.244259phosphoglycerol transferase
MGAS10750_Spy0697117-6.059724cell wall biogenesis glycosyltransferase
MGAS10750_Spy0698217-6.273294hypothetical protein
MGAS10750_Spy0699217-5.385123transcriptional activator amrA
MGAS10750_Spy0700215-3.425722hypothetical protein
MGAS10750_Spy0701-215-0.877386peptidase T
MGAS10750_Spy0702-120-1.110809Pore forming protein ebsA
MGAS10750_Spy07032240.552306Ferredoxin
10MGAS10750_Spy0829MGAS10750_Spy0884Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy0829223-1.714197dTDP-4-dehydrorhamnose 3,5-epimerase
MGAS10750_Spy0830224-2.812692dTDP-glucose 4,6-dehydratase
MGAS10750_Spy0831226-3.853475DNA integration/recombination/inversion protein
MGAS10750_Spy0832228-6.194276phage protein
MGAS10750_Spy0833229-3.922581phage protein
MGAS10750_Spy0834328-3.985712phage protein
MGAS10750_Spy0835325-3.668103phage protein
MGAS10750_Spy0836724-3.609994MerR family transcriptional regulator
MGAS10750_Spy0837423-4.119648Cro family transcriptional regulator
MGAS10750_Spy0838123-2.464688phage protein
MGAS10750_Spy0839220-2.624690phage protein
MGAS10750_Spy0840118-1.908801Cro/CI family transcriptional regulator
MGAS10750_Spy0841-117-1.757675phage protein
MGAS10750_Spy0842117-1.615910phage protein
MGAS10750_Spy0843218-1.290582phage DNA/RNA helicase
MGAS10750_Spy0844321-1.735540phage protein
MGAS10750_Spy0845223-1.400211phage protein
MGAS10750_Spy0846325-1.376003DNA primase
MGAS10750_Spy0847225-2.508345DNA primase
MGAS10750_Spy0848127-2.167530phage protein
MGAS10750_Spy0849330-2.569829phage protein
MGAS10750_Spy0850229-1.691340phage protein
MGAS10750_Spy0851126-1.340175phage protein
MGAS10750_Spy0852226-0.915065phage protein
MGAS10750_Spy08531271.580573phage protein
MGAS10750_Spy08540262.179628phage protein
MGAS10750_Spy08551221.964245phage protein
MGAS10750_Spy08563231.550418phage encoded transcriptional regulator, ArpU
MGAS10750_Spy08573231.363232phage protein
MGAS10750_Spy08583220.982527phage protein
MGAS10750_Spy08593200.735967phage protein
MGAS10750_Spy08603180.929882Terminase large subunit
MGAS10750_Spy08614200.850583Portal protein
MGAS10750_Spy08624200.737668phage protein
MGAS10750_Spy08636261.158321phage protein
MGAS10750_Spy08644241.229228phage scaffold protein
MGAS10750_Spy08654241.029903phage protein
MGAS10750_Spy08665240.555723phage protein
MGAS10750_Spy08676220.185925phage protein
MGAS10750_Spy08684200.832470phage protein
MGAS10750_Spy08693212.151936antigen C
MGAS10750_Spy08703211.482881antigen B
MGAS10750_Spy08713201.953636antigen A
MGAS10750_Spy08723202.142245phage protein
MGAS10750_Spy08733202.096629phage protein
MGAS10750_Spy08743201.869982phage protein
MGAS10750_Spy08753191.217886phage tail protein
MGAS10750_Spy08763181.469112phage protein
MGAS10750_Spy08774161.134577phage structural protein
MGAS10750_Spy0878418-0.584100phage protein
MGAS10750_Spy0879421-0.349651phage protein
MGAS10750_Spy08804210.076436phage protein
MGAS10750_Spy0881620-0.019779N-acetylmuramoyl-L-alanine amidase
MGAS10750_Spy0882517-1.424541phage-associated cell wall hydrolase
MGAS10750_Spy0883315-2.844480phage protein
MGAS10750_Spy0884315-2.585412phage protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0830NUCEPIMERASE1332e-38 Nucleotide sugar epimerase signature.
		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

Length = 334

Score = 133 bits (336), Expect = 2e-38
Identities = 74/344 (21%), Positives = 136/344 (39%), Gaps = 44/344 (12%)

Query: 4 NIIVTGGAGFIGSNFVHY-VYNNHPDVHVTVLDKLT--YAGN--RANIEAILGDRVELVV 58
+VTG AGFIG + + H V +D L Y + +A +E + +
Sbjct: 2 KYLVTGAAGFIGFHVSKRLLEAGH---QVVGIDNLNDYYDVSLKQARLELLAQPGFQFHK 58

Query: 59 GDIADAELVDKLAA--KADAIVHYAAESHNDNSLEDPSPFIHTNFIGTYTLLEAARKYDI 116
D+AD E + L A + + SLE+P + +N G +LE R I
Sbjct: 59 IDLADREGMTDLFASGHFERVFISPHRLAVRYSLENPHAYADSNLTGFLNILEGCRHNKI 118

Query: 117 RFHHV--STDEVYGDLPLREDLPGQGEGPGEKFTAETKYNPSSPYSSTKAASDLIVKAWV 174
+ H + S+ VYG L +P + + +P S Y++TK A++L+ +
Sbjct: 119 Q-HLLYASSSSVYG---LNRKMPFSTDDSVD--------HPVSLYAATKKANELMAHTYS 166

Query: 175 RSFGVKATISNCSNNYGPYQHIEKFIPRQITNILAGIKPKLYGEGKNVRDWIHTNDHSTG 234
+G+ AT YGP+ + + + +L G +Y GK RD+ + +D +
Sbjct: 167 HLYGLPATGLRFFTVYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYIDDIAEA 226

Query: 235 VWAIL------------------TKGRIGETYLIGADGEKNNKEVLELILEKMGQPKDAY 276
+ + Y IG + ++ + + +G
Sbjct: 227 IIRLQDVIPHADTQWTVETGTPAASIAPYRVYNIGNSSPVELMDYIQALEDALGIEAKK- 285

Query: 277 DHVTDRAGHDLRYAIDSTKLREELGWEPQFTNFSEGLEETIKWY 320
+ + + G L + D+ L E +G+ P+ T +G++ + WY
Sbjct: 286 NMLPLQPGDVLETSADTKALYEVIGFTPE-TTVKDGVKNFVNWY 328


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0843SECA290.028 SecA protein signature.
		>SECA#SecA protein signature.

Length = 901

Score = 29.5 bits (66), Expect = 0.028
Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 1/68 (1%)

Query: 165 VIKH-YEKLAKGKQAIVYTHSVEASHLVSDTFNQAGYQSQSVSGKTSKSEREEAMQAFRD 223
+I+ E+ AKG+ +V T S+E S LVS+ +AG + ++ K +E QA
Sbjct: 438 IIEDIKERTAKGQPVLVGTISIEKSELVSNELTKAGIKHNVLNAKFHANEAAIVAQAGYP 497

Query: 224 GKLRILVN 231
+ I N
Sbjct: 498 AAVTIATN 505


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0868PF05272250.046 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 25.4 bits (55), Expect = 0.046
Identities = 14/55 (25%), Positives = 19/55 (34%), Gaps = 4/55 (7%)

Query: 10 TPQKTGKKDKLGNDITKDVVKRDAKGRFTEWSADDVSLYGRDLTSSARKLLTNQV 64
P+K G D D + F EW D+V+ L R LL +
Sbjct: 402 PPKKRDPSAGAGTDPGGPGGGDDGEDPFGEWLDDEVA----RLRLRGRWLLKPRR 452


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0876FLGFLGJ405e-05 Flagellar protein FlgJ signature.
		>FLGFLGJ#Flagellar protein FlgJ signature.

Length = 313

Score = 39.7 bits (92), Expect = 5e-05
Identities = 32/139 (23%), Positives = 56/139 (40%), Gaps = 9/139 (6%)

Query: 294 VFSQLYLESFWGDTPVGRAD----NNWGGI----TWTGATTRPSGINVSQGQPRAEGGHY 345
+ +Q LES WG + R + N G+ W G T + G+ + +
Sbjct: 174 ILAQAALESGWGQRQIRRENGEPSYNLFGVKASGNWKGPVTEITTTEYENGEAKKVKAKF 233

Query: 346 NHYASVDDYLKDYTYLLAEQGIY-AVKGKLTIDEYTRGLFRVGGATYDYAAAGYDHYAPL 404
Y+S + L DY LL Y AV + ++ + L G AT + A +
Sbjct: 234 RVYSSYLEALSDYVGLLTRNPRYAAVTTAASAEQGAQALQDAGYATDPHYARKLTNMIQQ 293

Query: 405 MRDIRAGINRNNNGAMDNV 423
M+ I +++ + +DN+
Sbjct: 294 MKSISDKVSKTYSMNIDNL 312


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0879CARBMTKINASE260.007 Bacterial carbamate kinase signature.
		>CARBMTKINASE#Bacterial carbamate kinase signature.

Length = 314

Score = 25.9 bits (57), Expect = 0.007
Identities = 13/41 (31%), Positives = 18/41 (43%), Gaps = 14/41 (34%)

Query: 25 EFGWITLEDVPKKYR--------------DKVKQLVESGNI 51
E GWI ED + +R + +K+LVE G I
Sbjct: 148 EKGWIVKEDSGRGWRRVVPSPDPKGHVEAETIKKLVERGVI 188


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0880FRAGILYSIN280.006 Fragilysin metallopeptidase (M10C) enterotoxin signat...
		>FRAGILYSIN#Fragilysin metallopeptidase (M10C) enterotoxin

signature.
Length = 405

Score = 28.5 bits (63), Expect = 0.006
Identities = 15/63 (23%), Positives = 25/63 (39%), Gaps = 5/63 (7%)

Query: 40 VSAPVKHVLDNNKKAMEALESAIVKISDD-----LKDNNFKWTESKNHRDRLQKVQDQHE 94
+ APV +D + L + + +SD LKDN F + R + D
Sbjct: 38 IDAPVTASIDLQSVSYTDLATQLNDVSDFGKMIILKDNGFNRQVHVSMDKRTKIQLDNEN 97

Query: 95 IRI 97
+R+
Sbjct: 98 VRL 100


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0881UREASE280.009 Urea amidohydrolase (urease) protein signature.
		>UREASE#Urea amidohydrolase (urease) protein signature.

Length = 570

Score = 27.8 bits (62), Expect = 0.009
Identities = 11/54 (20%), Positives = 21/54 (38%), Gaps = 5/54 (9%)

Query: 46 VARNAVEAVEQIAYDKDIK---GIEKLTEAKIAVRDELSKHNVYLSDK--QMEV 94
++V V Q + D + G+ K A R + K ++ + +EV
Sbjct: 486 RTNSSVTFVSQASLDAGLAGRLGVAKELVAVQNTRGGIGKASMIHNSLTPHIEV 539


11MGAS10750_Spy0919MGAS10750_Spy0928Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy0919013-3.050080Haloacid dehalogenase-like hydrolase
MGAS10750_Spy0920113-3.818101hypothetical protein
MGAS10750_Spy0921315-3.888970hypothetical protein
MGAS10750_Spy0922219-0.295585hypothetical protein
MGAS10750_Spy0923-1163.458994hypothetical protein
MGAS10750_Spy09240174.184261hypothetical protein
MGAS10750_Spy09250176.039169nucleoside diphosphate kinase
MGAS10750_Spy09260165.674474nucleoside diphosphate kinase
MGAS10750_Spy09271165.336575GTP-binding protein LepA
MGAS10750_Spy09283185.073695Collagen-like surface protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0923PF04605280.008 Virulence-associated protein D (VapD)
		>PF04605#Virulence-associated protein D (VapD)

Length = 125

Score = 27.5 bits (61), Expect = 0.008
Identities = 15/44 (34%), Positives = 23/44 (52%), Gaps = 5/44 (11%)

Query: 7 RMILMFDMPTDTAEE-----RKAYRKFRKFLLSEGFIMHQFSIY 45
R + FD+ T + E+ R+ Y +KF+L GF Q+S Y
Sbjct: 5 RKAINFDLSTKSLEKYFKDTREPYSLIKKFMLENGFEHRQYSGY 48


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0927TCRTETOQM1591e-43 Tetracycline resistance protein TetO/TetQ/TetM family ...
		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

signature.
Length = 639

Score = 159 bits (403), Expect = 1e-43
Identities = 90/437 (20%), Positives = 178/437 (40%), Gaps = 85/437 (19%)

Query: 12 KIRNFSIIAHIDHGKSTLADRILEK---TETVSSREMQAQLLDSMDLERERGITIKLNAI 68
KI N ++AH+D GK+TL + +L + S + D+ LER+RGITI+
Sbjct: 2 KIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGIT 61

Query: 69 ELNYTAKDGETYIFHLIDTPGHVDFTYEVSRSLAACEGAILVVDAAQGIEAQTLANVYLA 128
+ E ++IDTPGH+DF EV RSL+ +GAIL++ A G++AQT +
Sbjct: 62 SFQW-----ENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHAL 116

Query: 129 LDNDLEILPVINKIDLPAADPERVRHEVEDVIG--------------------------- 161
+ + INKID D V ++++ +
Sbjct: 117 RKMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVELYPNMCVTNFTESEQWD 176

Query: 162 --LDASEAVLASAKAGIGI--EEI--------------------------LEQIVEKV-- 189
++ ++ +L +G + E+ ++ ++E +
Sbjct: 177 TVIEGNDDLLEKYMSGKSLEALELEQEESIRFHNCSLFPVYHGSAKNNIGIDNLIEVITN 236

Query: 190 --PAPTGDVDAPLQALIFDSVYDAYRGVILQVRIVNGIVKPGDKIQMMSNGKTFDVTEVG 247
+ T + L +F Y R + +R+ +G++ D +++ K +TE+
Sbjct: 237 KFYSSTHRGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLHLRDSVRISEKEKI-KITEMY 295

Query: 248 IFTP-KAVGRDFLATGDVGYVAASIKTVADTRVGDTVTLANNPAKEALHGYKQMNPMVFA 306
+ D +G++ + + +GDT L E P++
Sbjct: 296 TSINGELCKIDKAYSGEIVILQNEFLKLNSV-LGDTKLLPQRERIENPL------PLLQT 348

Query: 307 GIYPIESNKYNDLREALEKLQLNDASLQFE--PETSQALGFGFRCGFLGLLHMDVIQERL 364
+ P + + L +AL ++ +D L++ T + + FLG + M+V L
Sbjct: 349 TVEPSKPQQREMLLDALLEISDSDPLLRYYVDSATHEII-----LSFLGKVQMEVTCALL 403

Query: 365 EREFNIDLIMTAPSVVY 381
+ ++++++ + P+V+Y
Sbjct: 404 QEKYHVEIEIKEPTVIY 420



Score = 43.7 bits (103), Expect = 2e-06
Identities = 21/104 (20%), Positives = 41/104 (39%), Gaps = 12/104 (11%)

Query: 393 VSNPSEFPDPTRVAFIE----------EPYVKAQIMVPQEFVGAVMELSQRKRGDFVTMD 442
VS P++F + + EPY+ +I PQE++ + + + V
Sbjct: 510 VSTPADFRMLAPIVLEQVLKKAGTELLEPYLSFKIYAPQEYLSRAYTDAPKYCANIVDTQ 569

Query: 443 YIDDNRVNVIYQIPLAEIVFDFFDKLKSSTRGYASFDYDMSEYR 486
+ +N V + +IP I ++ L T G + ++ Y
Sbjct: 570 -LKNNEVILSGEIPARCI-QEYRSDLTFFTNGRSVCLTELKGYH 611


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0928GPOSANCHOR683e-14 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 67.8 bits (165), Expect = 3e-14
Identities = 39/105 (37%), Positives = 49/105 (46%), Gaps = 9/105 (8%)

Query: 324 LPGKPAPQTPEVPQKPDTAPHTPKTPQIPGQSKDVTPAPQNPSNRGLNKLQTQGGNQLAK 383
L K A Q E+ + +TP P N + G + G
Sbjct: 444 LKEKLAKQAEELAKLRAGKASDSQTP---------DAKPGNKAVPGKGQAPQAGTKPNQN 494

Query: 384 TPAAHDTHRQLPATGETTNPFFTAAAVAIMTTAGVVAVAKRQENN 428
+T RQLP+TGET NPFFTAAA+ +M TAGV AV KR+E N
Sbjct: 495 KAPMKETKRQLPSTGETANPFFTAAALTVMATAGVAAVVKRKEEN 539


12MGAS10750_Spy0940MGAS10750_Spy0962Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy0940-1183.272253NAD(P)H-dependent quinone reductase
MGAS10750_Spy09410183.594374dipeptidase PepV
MGAS10750_Spy09423213.031088tRNA modification GTPase TrmE
MGAS10750_Spy09436252.11362050S ribosomal protein L10
MGAS10750_Spy09443221.22869650S ribosomal protein L7/L12
MGAS10750_Spy0945128-0.437573hypothetical protein
MGAS10750_Spy0946228-1.811296hypothetical protein
MGAS10750_Spy0947429-3.002507hypothetical protein
MGAS10750_Spy0948725-4.502290DNA-cytosine methyltransferase
MGAS10750_Spy0949526-7.465437Relaxase
MGAS10750_Spy0950525-7.610986Relaxase
MGAS10750_Spy0951427-8.580456Relaxase
MGAS10750_Spy0952429-8.740604Relaxase
MGAS10750_Spy0953529-9.388737lantibiotic biosynthesis two-component response
MGAS10750_Spy0954528-9.336314lantibiotic biosynthesis sensor protein
MGAS10750_Spy0955629-9.368628lantibiotic srtA precursor
MGAS10750_Spy0956629-9.556723lantibiotic transport permease / lantibiotic
MGAS10750_Spy0957629-9.282944Lanthionine synthetase
MGAS10750_Spy0958526-9.056653serine/threoninedehydratase
MGAS10750_Spy0959324-8.062374lantibiotic transport ATP-binding protein
MGAS10750_Spy0960226-8.392020lantibiotic transport permease
MGAS10750_Spy0961126-7.200425lantibiotic transport permease
MGAS10750_Spy0962023-4.934826Cro/CI family transcriptional regulator
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0953HTHFIS742e-17 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 73.7 bits (181), Expect = 2e-17
Identities = 30/130 (23%), Positives = 57/130 (43%), Gaps = 1/130 (0%)

Query: 3 KILAIDDDKEILKLMKTALEIENYHVITCQEIELPIVFDDFKGYDLILLDIMMPNISGTE 62
IL DDD I ++ AL Y V + DL++ D++MP+ + +
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64

Query: 63 FCYKIREE-VHSPIIFVSALDGDNEIVQALNIGGDDFIVKPFSLKQFVAKVNSHLKREER 121
+I++ P++ +SA + ++A G D++ KPF L + + + L +R
Sbjct: 65 LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKR 124

Query: 122 AKIKNEAEER 131
K E + +
Sbjct: 125 RPSKLEDDSQ 134


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0955NISIN260.002 Nisin signature.
		>NISIN#Nisin signature.

Length = 57

Score = 26.3 bits (57), Expect = 0.002
Identities = 17/32 (53%), Positives = 23/32 (71%), Gaps = 2/32 (6%)

Query: 4 TIKDFDLDL-KTNKKDT-ATPYVGSRYLCTPG 33
+ KDF+LDL +KKD+ A+P + S LCTPG
Sbjct: 2 STKDFNLDLVSVSKKDSGASPRITSISLCTPG 33


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0960ANTHRAXTOXNA310.003 Anthrax toxin LF subunit signature.
		>ANTHRAXTOXNA#Anthrax toxin LF subunit signature.

Length = 800

Score = 31.3 bits (70), Expect = 0.003
Identities = 17/47 (36%), Positives = 29/47 (61%), Gaps = 7/47 (14%)

Query: 184 NKWYLFPYDWSLKLLEPMTRMRINSIPFGAEFVPDYSQIFISLFLGI 230
NK Y+ +W+ +P+T+ +IN+IP AEF+ + S I S +G+
Sbjct: 639 NKAYI---EWT----DPITKAKINTIPTSAEFIKNLSSIRRSSNVGV 678


13MGAS10750_Spy0974MGAS10750_Spy0990Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy09742150.725509dihydroneopterin aldolase
MGAS10750_Spy09751150.1410482-amino-4-hydroxy-6-
MGAS10750_Spy0976215-0.143721UDP-N-acetylenolpyruvoylglucosamine reductase
MGAS10750_Spy0977116-0.359902Spermidine/putrescine transport ATP-binding
MGAS10750_Spy09782160.347372Spermidine/putrescine transport system permease
MGAS10750_Spy09792150.735794Spermidine/putrescine transport system permease
MGAS10750_Spy09801150.799151Spermidine/putrescine-binding protein
MGAS10750_Spy09811150.792200DpiA family transcriptional regulator
MGAS10750_Spy09821150.758844Sensor kinase dpiB
MGAS10750_Spy0983216-0.075351Malate-sodium symport
MGAS10750_Spy0984220-1.447754NAD-dependent malic enzyme
MGAS10750_Spy0985020-4.027179Zn-dependent alcohol dehydrogenase
MGAS10750_Spy0986123-5.474984acid phosphatase/phosphotransferase
MGAS10750_Spy0987-122-4.952274chloride channel protein
MGAS10750_Spy0988020-4.577787Lipase/acylhydrolase family protein
MGAS10750_Spy0989-117-4.592523hypothetical protein
MGAS10750_Spy0990-115-3.004630hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0980MYCMG045371e-04 Hypothetical mycoplasma lipoprotein (MG045) signature.
		>MYCMG045#Hypothetical mycoplasma lipoprotein (MG045) signature.

Length = 483

Score = 36.6 bits (84), Expect = 1e-04
Identities = 24/82 (29%), Positives = 42/82 (51%), Gaps = 4/82 (4%)

Query: 31 SGSQSDKLVIYNWGDYIDPALLKKFTKETGIEVQYETFDSNEAMYTKIKQGGTTYDIAVP 90
S S V+ N+ YI P LL++ + + + T+ SNE + TY +AV
Sbjct: 21 SSCGSTTFVLANFESYISPLLLER--VQEKHPLTFLTYPSNEKLINGF--ANNTYSVAVA 76

Query: 91 SDYTIDKMIKENLLNKLDKSKL 112
S Y + ++I+ +LL+ +D S+
Sbjct: 77 STYAVSELIERDLLSPIDWSQF 98


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0981HTHFIS673e-15 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 67.2 bits (164), Expect = 3e-15
Identities = 23/131 (17%), Positives = 50/131 (38%), Gaps = 2/131 (1%)

Query: 3 VLIIEDDPMVDFIHRNYLEKLNLFDRIISSDSMKAVQSILTDYAIDLILLDIHITDGNGI 62
+L+ +DD + + L + + + + + + DL++ D+ + D N
Sbjct: 6 ILVADDDAAIRTVLNQALSRAGY--DVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAF 63

Query: 63 QFLEKWRAQHIPCEVIIISAANDGNIIRDGFHLGIIDYLIKPFTFERFQESIQQFVTHRE 122
L + + V+++SA N G DYL KPF I + + +
Sbjct: 64 DLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPK 123

Query: 123 HLANQQLEQAQ 133
++ + +Q
Sbjct: 124 RRPSKLEDDSQ 134


14MGAS10750_Spy1041MGAS10750_Spy1055Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy1041-1133.095826hypothetical protein
MGAS10750_Spy1042-1123.379516tRNA (uracil-5-)-methyltransferase Gid
MGAS10750_Spy10431131.939053oxaloacetate decarboxylase
MGAS10750_Spy10440131.702967hypothetical protein
MGAS10750_Spy10451131.668712Biotin carboxyl carrier protein of oxaloacetate
MGAS10750_Spy10461142.009424Na+ transporting oxaloacetate decarboxylase beta
MGAS10750_Spy1047-1151.7112172'-(5''-triphosphoribosyl)-3-dephospho-CoA
MGAS10750_Spy1048-1181.683261GntR family transcriptional regulator
MGAS10750_Spy10490222.627791hypothetical protein
MGAS10750_Spy1050-1223.266497hypothetical protein
MGAS10750_Spy10510203.878495acetyl-CoA carboxylase biotin carboxyl carrier
MGAS10750_Spy10521193.544614Na+ transporting oxaloacetate decarboxylase beta
MGAS10750_Spy10531173.367638Na+ transporting oxaloacetate decarboxylase beta
MGAS10750_Spy10540163.606716hypothetical protein
MGAS10750_Spy1055-1133.029861citrate lyase subunit gamma
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1041TYPE3IMSPROT320.002 Type III secretion system inner membrane S protein ...
		>TYPE3IMSPROT#Type III secretion system inner membrane S protein

family signature.
Length = 354

Score = 32.0 bits (73), Expect = 0.002
Identities = 14/75 (18%), Positives = 27/75 (36%), Gaps = 8/75 (10%)

Query: 172 TIGILERIVIGVCMIMG---QFASIGLVFTAKSIA-RYNKISESPAFAEYYLIGSLF--- 224
L ++ V +M G + + ++I KI+ + I SL
Sbjct: 82 EFFYLCFPLLTVAALMAIASHVVQYGFLISGEAIKPDIKKINPIEGAKRIFSIKSLVEFL 141

Query: 225 -SILSVFIAAWICFF 238
SIL V + + + +
Sbjct: 142 KSILKVVLLSILIWI 156


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1045RTXTOXIND270.025 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 26.7 bits (59), Expect = 0.025
Identities = 8/28 (28%), Positives = 14/28 (50%)

Query: 87 EILAPADGLVSKIHVVANQTVESEQVLI 114
EI + +V +I V ++V VL+
Sbjct: 98 EIKPIENSIVKEIIVKEGESVRKGDVLL 125



Score = 26.3 bits (58), Expect = 0.031
Identities = 13/40 (32%), Positives = 22/40 (55%)

Query: 51 VKAPMSGTVLSIFATEGKAVKKGEAVLVLEAMKMENEILA 90
+K + V I EG++V+KG+ +L L A+ E + L
Sbjct: 99 IKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLK 138


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1051RTXTOXIND290.004 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 29.4 bits (66), Expect = 0.004
Identities = 10/49 (20%), Positives = 22/49 (44%)

Query: 65 AIPSPMPGTILKVLVAVGDQVTENQPLLILEAMKMENEIVASSAGTITA 113
I + +++V G+ V + LL L A+ E + + + + + A
Sbjct: 98 EIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQA 146



Score = 26.7 bits (59), Expect = 0.030
Identities = 9/30 (30%), Positives = 14/30 (46%)

Query: 102 EIVASSAGTITAIHVGQGQVVNPGDGLITI 131
EI + I V +G+ V GD L+ +
Sbjct: 98 EIKPIENSIVKEIIVKEGESVRKGDVLLKL 127


15MGAS10750_Spy1091MGAS10750_Spy1096Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy1091022-4.530846nucleoside-binding protein
MGAS10750_Spy1092122-6.029964cytidine deaminase
MGAS10750_Spy1093018-4.69973316S rRNA m(2)G 1207 methyltransferase
MGAS10750_Spy1094018-4.742522pantothenate kinase
MGAS10750_Spy1095118-4.24799630S ribosomal protein S20
MGAS10750_Spy1096-116-3.886659Sensor protein ciaH
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1091LIPPROTEIN48665e-14 Mycoplasma P48 major surface lipoprotein signature.
		>LIPPROTEIN48#Mycoplasma P48 major surface lipoprotein signature.

Length = 428

Score = 65.8 bits (160), Expect = 5e-14
Identities = 76/299 (25%), Positives = 120/299 (40%), Gaps = 45/299 (15%)

Query: 36 DLKVAMVTDTGGVDDKSFNQSAWEGLQSWGKEMGLQKGTGFDYFQSTSESEYATNLDTAV 95
LK ++TD G +DDKSFNQSA+E L++ + K TG + S + + ++A+
Sbjct: 61 KLKPVLITDEGKIDDKSFNQSAFEALKA------INKQTGIEINNVEPSSNFESAYNSAL 114

Query: 96 SGGYQLIYGIGFALKDAIAKAAGD------NEGVKFVIIDDIIEGKDNV-ASVTFADHEA 148
S G+++ GF + +I + +K + ID IE + S+ F E+
Sbjct: 115 SAGHKIWVLNGFKHQQSIKQYIDAHREELERNQIKIIGIDFDIETEYKWFYSLQFNIKES 174

Query: 149 AYLAGIAAAKTTKTK-----TVGFVGGMEGTVITRFEKGFEAGVKS---------VDDTI 194
A+ G A A + V GG +T F +GF G+ + T
Sbjct: 175 AFTTGYAIASWLSEQDESKRVVASFGGGAFPGVTTFNEGFAKGILYYNQKHKSSKIYHTS 234

Query: 195 QVKVDYAGSFGDAAKGKTIAAAQYAAGADVIYQAAGG---TGAGVFNEAKAINEKRSEAD 251
VK+D +G I + ADV Y G F + N+ +
Sbjct: 235 PVKLD-SGFTAGEKMNTVINNVLSSTPADVKYNPHVILSVAGPATFETVRLANKGQ---- 289

Query: 252 KVWVIGVDRDQKDEGKYTSKDGKEANFVLASSIKEVGKAVQLINKQVADKKFPGGKTTV 310
+VIGVD DQ +D +L S +K + +AV + +K G K V
Sbjct: 290 --YVIGVDSDQG-----MIQDKDR---ILTSVLKHIKQAVYETLLDLILEKEEGYKPYV 338


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1096PF06580392e-05 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 39.1 bits (91), Expect = 2e-05
Identities = 15/75 (20%), Positives = 31/75 (41%), Gaps = 5/75 (6%)

Query: 312 YGKIFYFQNQVNRSLRMDKALLKQLITILFDNAIKY----TDKNGIIEIIVKTTDKNLLI 367
+ F+NQ+N ++ D + L+ L +N IK+ + G I + + + +
Sbjct: 236 FEDRLQFENQINPAIM-DVQVPPMLVQTLVENGIKHGIAQLPQGGKILLKGTKDNGTVTL 294

Query: 368 SVIDNGPGITDEEKK 382
V + G K+
Sbjct: 295 EVENTGSLALKNTKE 309


16MGAS10750_Spy1114MGAS10750_Spy1121Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy1114216-0.243353membrane protein
MGAS10750_Spy1115217-0.327470Type I restriction-modification system
MGAS10750_Spy1116116-0.725148ABC transporter permease
MGAS10750_Spy1117-119-2.138291ABC transporter ATP-binding protein
MGAS10750_Spy1118120-3.705391TetR family transcriptional regulator
MGAS10750_Spy1119022-4.549777hypothetical protein
MGAS10750_Spy1120-122-4.716110GntR family transcriptional regulator
MGAS10750_Spy1121-124-4.055397General stress protein, Gls24 family
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1117PF05272347e-04 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 33.5 bits (76), Expect = 7e-04
Identities = 18/41 (43%), Positives = 23/41 (56%), Gaps = 2/41 (4%)

Query: 36 KGELVVIL-GASGAGKSTVLNILGGMD-TVDAGQVIIDGKD 74
K + V+L G G GKST++N L G+D D I GKD
Sbjct: 594 KFDYSVVLEGTGGIGKSTLINTLVGLDFFSDTHFDIGTGKD 634


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1118HTHTETR416e-07 TetR bacterial regulatory protein HTH signature.
		>HTHTETR#TetR bacterial regulatory protein HTH signature.

Length = 215

Score = 41.2 bits (96), Expect = 6e-07
Identities = 13/48 (27%), Positives = 25/48 (52%)

Query: 4 RHTETKAYVKTALTTLLTEQSFETLTVSDLTKKAGINRGTFYLHYTDK 51
ET+ ++ L ++Q + ++ ++ K AG+ RG Y H+ DK
Sbjct: 8 EAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDK 55


17MGAS10750_Spy1279MGAS10750_Spy1288Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy12795263.046145phage protein
MGAS10750_Spy12804251.717249Holin
MGAS10750_Spy12813221.262421phage protein
MGAS10750_Spy12821201.057255phage protein
MGAS10750_Spy12832181.175375phage protein
MGAS10750_Spy12842171.088704phage infection protein
MGAS10750_Spy12851160.499431Hyaluronoglucosaminidase
MGAS10750_Spy12860150.436086phage endopeptidase
MGAS10750_Spy12871160.293407phage protein
MGAS10750_Spy12882150.596991phage protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1282IGASERPTASE320.002 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 32.3 bits (73), Expect = 0.002
Identities = 13/42 (30%), Positives = 22/42 (52%)

Query: 64 TKYAVAESVQKVEELSLAQKEIEQNAEQAKVTAEAAEKQAKS 105
T+ + VE+ A+ E E+ E KVT++ + KQ +S
Sbjct: 1095 TQTTETKETATVEKEEKAKVETEKTQEVPKVTSQVSPKQEQS 1136


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1285PF072125480.0 Hyaluronoglucosaminidase
		>PF07212#Hyaluronoglucosaminidase

Length = 336

Score = 548 bits (1414), Expect = 0.0
Identities = 269/371 (72%), Positives = 297/371 (80%), Gaps = 37/371 (9%)

Query: 1 MTETIPLRVQFKRMKAAEWASSDVVLLEGEIGFETDTGFAKFGDGQNTFSKLKYLTGPKG 60
MTETIPLRVQFKRM A EW SDV+LLE EIGFETDTG+AKFGDG+N FSKLKYL
Sbjct: 1 MTETIPLRVQFKRMTAEEWTRSDVILLESEIGFETDTGYAKFGDGKNQFSKLKYL----- 55

Query: 61 PKGDTGIQGKTGGTGPRGPAGKPGTTDYDQLQNKPDLGAFAQKEETNSKITKLESSKADK 120
NKPDLGAFAQKEETNSKITKLESSKADK
Sbjct: 56 --------------------------------NKPDLGAFAQKEETNSKITKLESSKADK 83

Query: 121 SAVYSKAESKIELDKKLSLTGGIVTGQLQFKPNKSGIKPSSSVGGAINIDMSKSEGAAMV 180
+AVY KAESKIELDKKL+L GG++TGQLQFKPNKSGIKPSSSVGGAINIDMSKSEGA +V
Sbjct: 84 NAVYLKAESKIELDKKLNLKGGVMTGQLQFKPNKSGIKPSSSVGGAINIDMSKSEGAGVV 143

Query: 181 MYTNKDTTDGPLMILRSDKDTFDQSAQFVDYSGKTNAVNIVMRQPSAPNFSSALNITSAN 240
+Y+N DT+DGPLM LR+ K+TF+QSA FVDYSGKTNAVNI MRQP+ PNFSSALNITS N
Sbjct: 144 VYSNNDTSDGPLMSLRTGKETFNQSALFVDYSGKTNAVNIAMRQPTTPNFSSALNITSGN 203

Query: 241 EGGSAMQIRGVEKALGTLKITHENPNVEAKYDENAAALSIDIVKKQKGGKGTAAQGIYIN 300
E GSAMQIRGVEKALGTLKITHENPNVEA YDENAAALSIDIVKKQKGGKGTAAQGIYIN
Sbjct: 204 ENGSAMQIRGVEKALGTLKITHENPNVEANYDENAAALSIDIVKKQKGGKGTAAQGIYIN 263

Query: 301 STSGTAGKMLRIRNKNEDKFYVGPDGGFHSGANSTVAGNLTVNYPTSEKHAATKKYVDEK 360
STSGT GK+LRIRN +DKFYV DGGF++ S + GNL + PT++ HAATK YVD +
Sbjct: 264 STSGTTGKLLRIRNLGDDKFYVKHDGGFYAKKTSQIDGNLKLKNPTADDHAATKAYVDSE 323

Query: 361 IAELKKLILKK 371
+ +LK L++ K
Sbjct: 324 VKKLKALLMDK 334


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1288RTXTOXINA405e-05 Gram-negative bacterial RTX toxin determinant A family...
		>RTXTOXINA#Gram-negative bacterial RTX toxin determinant A family

signature.
Length = 1024

Score = 39.6 bits (92), Expect = 5e-05
Identities = 25/133 (18%), Positives = 59/133 (44%), Gaps = 7/133 (5%)

Query: 501 LGASGQGLSSMLSSAWGNIQTVVSTAKNMITLAIDGIKL--VFSNLGNAGNILKGLLSAA 558
G G + + G ++ST +N + A+ +K+ + + GN+ L+ A
Sbjct: 124 AGNILGGGAENIGDNLGKAGGILSTFQNFLGTALSSMKIDELIKKQKSGGNVSSSELAKA 183

Query: 559 WSAMQNAVVIAKGIINSAISAIKTAFSSFGNLVSSVSGTIKSVIGSLKNAFYSLASIDLV 618
+ N +V +N+ +++ ++ G+++S+ + + N +L ++D +
Sbjct: 184 SIELINQLVDTVASLNNNVNSFSQQLNTLGSVLSNTKH-----LNGVGNKLQNLPNLDNI 238

Query: 619 GAGRAIMQGFLNG 631
GAG + G L+
Sbjct: 239 GAGLDTVSGILSA 251


18MGAS10750_Spy1304MGAS10750_Spy1328Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy1304128-3.282249phage protein
MGAS10750_Spy1305226-1.708448HNH endonuclease family protein
MGAS10750_Spy1306123-3.091225phage protein
MGAS10750_Spy1307-120-2.588908phage protein
MGAS10750_Spy1308018-1.746375phage protein
MGAS10750_Spy1309-119-0.642564phage protein
MGAS10750_Spy1310018-1.041555phage protein
MGAS10750_Spy1311017-1.289468phage protein
MGAS10750_Spy1312017-0.723178phage protein
MGAS10750_Spy1313122-0.854166phage protein
MGAS10750_Spy1314223-0.490512phage protein
MGAS10750_Spy1315123-1.860363phage protein
MGAS10750_Spy1316226-1.488518RecT protein
MGAS10750_Spy1317227-0.869541RecT protein
MGAS10750_Spy1318330-1.118394phage protein
MGAS10750_Spy1319328-0.594950phage protein
MGAS10750_Spy1320227-1.551734phage protein
MGAS10750_Spy1321124-2.411883DNA replication protein dnaD
MGAS10750_Spy1322020-3.240977phage replication protein
MGAS10750_Spy1323120-3.682112phage protein
MGAS10750_Spy1324122-3.427061Excisionase
MGAS10750_Spy1325120-3.953747Cro/CI family transcriptional regulator
MGAS10750_Spy1326016-4.358822Cro/CI family transcriptional regulator
MGAS10750_Spy1327-117-3.967483phage protein
MGAS10750_Spy1328-117-3.308730DNA integration/recombination/inversion protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1326SACTRNSFRASE280.032 Streptothricin acetyltransferase signature.
		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

Length = 173

Score = 28.0 bits (62), Expect = 0.032
Identities = 13/37 (35%), Positives = 18/37 (48%)

Query: 139 KSEETEDYITDYVEGLVAAGLGAYQEDNLHMKVKLRS 175
K E +D YVE A Y E+N ++K+RS
Sbjct: 48 KQYEDDDMDVSYVEEEGKAAFLYYLENNCIGRIKIRS 84


19MGAS10750_Spy1366MGAS10750_Spy1380Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy1366317-2.692438hypothetical protein
MGAS10750_Spy1367116-2.180706Non-specific DNA-binding protein Dps /
MGAS10750_Spy1368219-2.295289Type 4 prepilin peptidase pilD
MGAS10750_Spy1369118-2.253816ribosomal RNA large subunit methyltransferase N
MGAS10750_Spy1370017-2.317634hypothetical protein
MGAS10750_Spy1371-215-0.871234hypothetical protein
MGAS10750_Spy1372-2130.173740ribose operon repressor
MGAS10750_Spy1373-1131.158321ATP-dependent endopeptidase Lon
MGAS10750_Spy13741141.600136phosphopantetheine adenylyltransferase
MGAS10750_Spy13752172.279022Methyltransferase
MGAS10750_Spy13763182.465183asparagine synthetase AsnA
MGAS10750_Spy13773242.318260carbamate kinase
MGAS10750_Spy13781201.516680hypothetical protein
MGAS10750_Spy13792231.158171arginine/ornithine antiporter
MGAS10750_Spy13803241.309172ornithine carbamoyltransferase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1367HELNAPAPROT1511e-49 Helicobacter neutrophil-activating protein A family ...
		>HELNAPAPROT#Helicobacter neutrophil-activating protein A family

signature.
Length = 153

Score = 151 bits (383), Expect = 1e-49
Identities = 49/154 (31%), Positives = 85/154 (55%), Gaps = 4/154 (2%)

Query: 19 KKEASKNEKT--KAVLNQAVADLSVAASIVHQVHWYMRGPGFLYLHPKMDELLDSLNANL 76
K E +K +T + LN +++ + S +H+ HWY++GP F LH K +EL D +
Sbjct: 2 KTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFFTLHEKFEELYDHAAETV 61

Query: 77 DEMSERLITIGGAPYSTLAEFSKHSKLDEAKGTYDKTVAQHLARLVEVYLYLSSLYQVGL 136
D ++ERL+ IGG P +T+ E+++H+ + + + + ++ + LV Y +SS + +
Sbjct: 62 DTIAERLLAIGGQPVATVKEYTEHASITDGGN--ETSASEMVQALVNDYKQISSESKFVI 119

Query: 137 DITDEEGDAGTNDLFTAAKTEAEKTIWMLQAERG 170
+ +E D T DLF E EK +WML + G
Sbjct: 120 GLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG 153


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1372HTHTETR337e-04 TetR bacterial regulatory protein HTH signature.
		>HTHTETR#TetR bacterial regulatory protein HTH signature.

Length = 215

Score = 33.4 bits (76), Expect = 7e-04
Identities = 9/34 (26%), Positives = 19/34 (55%)

Query: 8 KLILQGGKAMVTIKQVAEEAGVSRSTVSRYISQK 41
+L Q G + ++ ++A+ AGV+R + + K
Sbjct: 22 RLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDK 55


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1374LPSBIOSNTHSS1532e-50 Lipopolysaccharide core biosynthesis protein signat...
		>LPSBIOSNTHSS#Lipopolysaccharide core biosynthesis protein

signature.
Length = 166

Score = 153 bits (388), Expect = 2e-50
Identities = 58/157 (36%), Positives = 94/157 (59%), Gaps = 2/157 (1%)

Query: 5 IGLYTGSFDPVTNGHLDIVKRASGLFDQIYVGIFDNPTKKSYFKLEVRKAMLTQALADFT 64
+Y GSFDP+T GHLDI++R LFDQ+YV + NP K+ F ++ R + +A+A
Sbjct: 2 NAIYPGSFDPITFGHLDIIERGCRLFDQVYVAVLRNPNKQPMFSVQERLEQIAKAIAHLP 61

Query: 65 NVIVVTSHERLAIDVAKELRVTHLIRGLRNATDFEYEENLEYFNHLLAPNIETVYLISRN 124
N V + E L ++ A++ + ++RGLR +DFE E + N LA ++ETV+L +
Sbjct: 62 NAQVDSF-EGLTVNYARQRQAGAILRGLRVLSDFELELQMANTNKTLASDLETVFLTTST 120

Query: 125 KWQALSSSRVRELIHFQSSLEGLVPQSVIAQV-EKMN 160
++ LSSS V+E+ F ++E VP V A + ++ +
Sbjct: 121 EYSFLSSSLVKEVARFGGNVEHFVPSHVAAALYDQFH 157


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1377CARBMTKINASE407e-146 Bacterial carbamate kinase signature.
		>CARBMTKINASE#Bacterial carbamate kinase signature.

Length = 314

Score = 407 bits (1047), Expect = e-146
Identities = 141/315 (44%), Positives = 204/315 (64%), Gaps = 6/315 (1%)

Query: 3 KQKIVVALGGNAIL--STDASAKAQQEALMSTSKSLVKLIKEGHEVIVTHGNGPQVGNLL 60
+++V+ALGGNA+ S + + + T++ + ++I G+EV++THGNGPQVG+LL
Sbjct: 2 GKRVVIALGGNALQQRGQKGSYEEMMDNVRKTARQIAEIIARGYEVVITHGNGPQVGSLL 61

Query: 61 LQQAAADSEKN-PAMPLDTCVAMTEGSIGFWLVNALDNELQAQGIQKEVAAVVTQVIVDA 119
L A + PA P+D AM++G IG+ + AL NEL+ +G++K+V ++TQ IVD
Sbjct: 62 LHMDAGQATYGIPAQPMDVAGAMSQGWIGYMIQQALKNELRKRGMEKKVVTIITQTIVDK 121

Query: 120 KDPAFENPTKPIGPFLTEEDAKKQMAESGASFKEDAGRGWRKVVPSPKPVGIKEANVIRS 179
DPAF+NPTKP+GPF EE AK+ E G KED+GRGWR+VVPSP P G EA I+
Sbjct: 122 NDPAFQNPTKPVGPFYDEETAKRLAREKGWIVKEDSGRGWRRVVPSPDPKGHVEAETIKK 181

Query: 180 LVDSGVVVVSAGGGGVPVVEDATSKTLTGVEAVIDKDFASQTLSELVDADLFIVLTGVDN 239
LV+ GV+V+++GGGGVPV+ + + GVEAVIDKD A + L+E V+AD+F++LT V+
Sbjct: 182 LVERGVIVIASGGGGVPVILED--GEIKGVEAVIDKDLAGEKLAEEVNADIFMILTDVNG 239

Query: 240 VYVNFNKPDQTKLEEVTVSQMKEYITQDQFAPGSMLPKVEAAIAFVENKPNAKAIITSLE 299
+ + + L EV V ++++Y + F GSM PKV AAI F+E +AII LE
Sbjct: 240 AALYYGTEKEQWLREVKVEELRKYYEEGHFKAGSMGPKVLAAIRFIEW-GGERAIIAHLE 298

Query: 300 NIDNVLSANAGTQII 314
L GTQ++
Sbjct: 299 KAVEALEGKTGTQVL 313


20MGAS10750_Spy1400MGAS10750_Spy1432Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy14001234.431679valyl-tRNA synthetase
MGAS10750_Spy14010182.031388hypothetical protein
MGAS10750_Spy1402-1202.789470ribosomal-protein-serineacetyltransferase
MGAS10750_Spy1403-1202.087494hypothetical protein
MGAS10750_Spy1404-2191.632334hypothetical protein
MGAS10750_Spy1405-2191.496723hypothetical protein
MGAS10750_Spy1406-2172.200488*3-deoxy-7-phosphoheptulonate synthase
MGAS10750_Spy1407-2173.3993633-dehydroquinate synthase
MGAS10750_Spy14081204.371319hypothetical protein
MGAS10750_Spy14091183.530064acetate kinase
MGAS10750_Spy14100183.387259hypothetical protein
MGAS10750_Spy14111193.100207SAM-dependent methyltransferase
MGAS10750_Spy14120172.734065Shikimate 5-dehydrogenase
MGAS10750_Spy14131172.157351beta-galactosidase
MGAS10750_Spy14140170.462439two-component response regulator yesN
MGAS10750_Spy14150181.361881two-component sensor kinase yesM
MGAS10750_Spy14162191.165803hypothetical protein
MGAS10750_Spy14171182.550996Sugar-binding protein
MGAS10750_Spy14180193.122929sugar ABC transporter permease
MGAS10750_Spy14190183.318413sugar ABC transporter permease
MGAS10750_Spy1420-1194.164105glucokinase / transcription regulator
MGAS10750_Spy1421-2184.427699hypothetical protein
MGAS10750_Spy1422-3152.895681beta-glucosidase
MGAS10750_Spy1423-3162.516149Hyaluronoglucosaminidase
MGAS10750_Spy1424-4151.875123GntR family transcriptional regulator
MGAS10750_Spy1425-4151.504149hypothetical protein
MGAS10750_Spy1426-4150.874045alpha-mannosidase
MGAS10750_Spy1427-315-2.127848Sensory transduction protein kinase
MGAS10750_Spy1428-217-0.860629tRNA (uracil-5-) -methyltransferase
MGAS10750_Spy1429218-3.537815recombination regulator RecX
MGAS10750_Spy1430518-4.173964hypothetical protein
MGAS10750_Spy1431118-3.610043hypothetical protein
MGAS10750_Spy1432118-3.922332transposase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1400RTXTOXIND374e-04 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 36.7 bits (85), Expect = 4e-04
Identities = 11/74 (14%), Positives = 27/74 (36%), Gaps = 6/74 (8%)

Query: 805 YLPLADLLNVEEELARLDKELAKWQKELDMVGKKLGNERFVANAKPEVIQKEKDKQADYQ 864
+ +L E + EL ++ +L+ + ++ +AK E + + +
Sbjct: 248 AIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEI------LSAKEEYQLVTQLFKNEIL 301

Query: 865 AKYDATQERIAEMQ 878
K T + I +
Sbjct: 302 DKLRQTTDNIGLLT 315


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1414HTHFIS851e-19 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 84.9 bits (210), Expect = 1e-19
Identities = 31/133 (23%), Positives = 50/133 (37%), Gaps = 6/133 (4%)

Query: 4 KVLLVDDEYMILQGLTMIIDWQALGFEVVQTARSGKEALAYLTQYPVDVMISDVTMPGMT 63
+L+ DD+ I L + G++V + ++ D++++DV MP
Sbjct: 5 TILVADDDAAIRTVLNQAL--SRAGYDVR-ITSNAATLWRWIAAGDGDLVVTDVVMPDEN 61

Query: 64 GLDLIEAAKTYHPQLQTLILSGYQEFSYVQKAMELETKGYLLKPVDKAELQAKMKQFKDC 123
DL+ K P L L++S F KA E YL KP D L +
Sbjct: 62 AFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFD---LTELIGIIGRA 118

Query: 124 LDAQQAESIRQEA 136
L + + E
Sbjct: 119 LAEPKRRPSKLED 131


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1415PF065801792e-53 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 179 bits (456), Expect = 2e-53
Identities = 71/324 (21%), Positives = 132/324 (40%), Gaps = 34/324 (10%)

Query: 251 LSKAYRMQYNRSGDLLAYVAVRKSYLLAEAVRTVFVYGLVSLLLAWLLLQLL-FRVFRNY 309
L+ AYR R G L + + A + + V+ W LL + +
Sbjct: 55 LTHAYRSFIKRQG-WLKLNMGQIILRVLPACVVIGMVWFVANTSIWRLLAFINTKPVAFT 113

Query: 310 IQQVSEITDTVEMVAAGDLSLTIDNSHMELELYHISEAINQMLASIKAYIDEVYVLEVEQ 369
+ I V +V + M LY + +A ID+ +
Sbjct: 114 LPLALSIIFNVVVV-----------TFMWSLLYF---GWHFFKNYKQAEIDQWK-MASMA 158

Query: 370 RDAQMRALQSQINPHFLYNTLEYIRMYALSCQQEELADVIYAFASLLRNNI--SQDKMTT 427
++AQ+ AL++QINPHF++N L IR L + +++ + + L+R ++ S + +
Sbjct: 159 QEAQLMALKAQINPHFMFNALNNIRALILE-DPTKAREMLTSLSELMRYSLRYSNARQVS 217

Query: 428 LKEELAFCEKYIYLYQMRYPDSFAYHVKIDESIADLAIPKFVIQPLVENYFVHGIDYSRH 487
L +EL + Y+ L +++ D + +I+ +I D+ +P ++Q LVEN HGI
Sbjct: 218 LADELTVVDSYLQLASIQFEDRLQFENQINPAIMDVQVPPMLVQTLVENGIKHGIAQLPQ 277

Query: 488 DNALSIKALDETDHFLIQVLDNGRGISQERLADMERRLQEHQTTGNSSIGLQNVYLRLFH 547
+ +K + ++V + G L T ++ GLQNV RL
Sbjct: 278 GGKILLKGTKDNGTVTLEVENTG-------------SLALKNTKESTGTGLQNVRERLQM 324

Query: 548 HFRDRVSWSMAKEPNGGFIIQIRI 571
+ ++++ G + I
Sbjct: 325 LYGTEAQIKLSEKQ-GKVNAMVLI 347


21MGAS10750_Spy1485MGAS10750_Spy1502Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy14851143.418438transketolase
MGAS10750_Spy14860143.054122transketolase
MGAS10750_Spy14870132.978327translaldolase
MGAS10750_Spy14880132.729425trans-acting positive regulator
MGAS10750_Spy14890123.182204NADH peroxidase
MGAS10750_Spy1490-1144.001996glycerol uptake facilitator protein
MGAS10750_Spy1491-1143.681794alpha-glycerophosphate oxidase
MGAS10750_Spy14920143.383090glycerol kinase
MGAS10750_Spy1493-1192.510872hypothetical protein
MGAS10750_Spy1494-1153.086566hypothetical protein
MGAS10750_Spy1495-1133.533237glycyl-tRNA synthetase subunit beta
MGAS10750_Spy1496-1101.753022glycyl-tRNA synthetase subunit alpha
MGAS10750_Spy14970120.798172hypothetical protein
MGAS10750_Spy1498-1111.009082hypothetical protein
MGAS10750_Spy1499-1111.415901aldo/keto reductase
MGAS10750_Spy1500-3110.764645N-acetylglucosamine-6-phosphate deacetylase
MGAS10750_Spy15010100.076059Sodium-dependent phosphate transporter
MGAS10750_Spy15031110.749136hypothetical protein
MGAS10750_Spy1502291.340769hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1488PF05043555e-10 Transcriptional activator
		>PF05043#Transcriptional activator

Length = 493

Score = 54.6 bits (131), Expect = 5e-10
Identities = 30/162 (18%), Positives = 71/162 (43%), Gaps = 7/162 (4%)

Query: 23 IEDLMDKERRAQYRLLVTLYHAKETLRLKDLMRLSNLSKVTLLKYIDNLNHLCREQGLAC 82
+ DL+ K+ Q LL L+ K +L L N ++ + + ++ +
Sbjct: 1 MRDLLSKKSHRQLELLELLFEHKRWFHRSELAELLNCTERAVKDDLSHVKSAFPDLIF-- 58

Query: 83 QLLLEKDSLSLKENGQFHWEDLVALLLKESVAYQILTYMYCHEHFNITNLSVELMVSEAT 142
+ + E + K S + IL +++ +E ++ E +S ++
Sbjct: 59 -HSSTNGIRIINTDDS-DIEMVYHHFFKHSTHFSILEFIFFNEGCQAESICKEFYISSSS 116

Query: 143 LNRQLAHLNQLLS---EFDLALSQGRQLGSELQWRYFYFELF 181
L R ++ +N+++ +F+++L+ + +G+E RYF+ + F
Sbjct: 117 LYRIISQINKVIKRQFQFEVSLTPVQIIGNERDIRYFFAQYF 158


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1493THERMOLYSIN401e-06 Thermolysin metalloprotease (M4) family signature.
		>THERMOLYSIN#Thermolysin metalloprotease (M4) family signature.

Length = 544

Score = 40.0 bits (93), Expect = 1e-06
Identities = 15/78 (19%), Positives = 29/78 (37%), Gaps = 3/78 (3%)

Query: 69 NQPKTSQTSKKVKLSEDKAKSIALKDASVTEADAQMLSVTQDNEDGKAVYEIEFQNKDQE 128
+ S ++ +D A + + + E L + D E + YE+ +
Sbjct: 134 TEAAISIQQAEMIAKQDVADRVTKERPAAEEGKPTRLVIYPDEETPRLAYEVNVRFLTPV 193

Query: 129 ---YSYTIDANSGDIVEK 143
+ Y IDA G ++ K
Sbjct: 194 PGNWIYMIDAADGKVLNK 211


22MGAS10750_Spy1529MGAS10750_Spy1543Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy1529217-2.303256protein ecsB
MGAS10750_Spy1530217-1.022856ABC-type transporter ATP-binding protein ecsA
MGAS10750_Spy1531-114-0.688267Bis(5'-nucleosyl)-tetraphosphatase
MGAS10750_Spy1532-213-0.727302hypothetical protein
MGAS10750_Spy1533-317-0.101803LytR family transcriptional regulator
MGAS10750_Spy1534-2211.074966acetyltransferase
MGAS10750_Spy1535-1262.057383ATP/GTP hydrolase
MGAS10750_Spy15360271.977170Guanine-hypoxanthine permease
MGAS10750_Spy15370382.997007hydrolase
MGAS10750_Spy1538-1363.339886PTS system, mannose-specific IIAB component
MGAS10750_Spy1539-1273.382690PTS system, mannose-specific IIC component
MGAS10750_Spy1540-1172.927013PTS system, mannose-specific IID component
MGAS10750_Spy1541-1152.674492hypothetical protein
MGAS10750_Spy1542-1143.081512seryl-tRNA synthetase
MGAS10750_Spy15431143.078846acetyl-CoA carboxylase subunit alpha
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1534SACTRNSFRASE642e-15 Streptothricin acetyltransferase signature.
		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

Length = 173

Score = 63.8 bits (155), Expect = 2e-15
Identities = 27/86 (31%), Positives = 41/86 (47%), Gaps = 4/86 (4%)

Query: 62 CLLARLDEKVVGLLNLSGEVLSQGQVEADVFMLVAKTYRGYGIGQLLLEIALDWAEENPY 121
L L+ +G + + +E + VAK YR G+G LL A++WA+EN +
Sbjct: 67 AFLYYLENNCIGRIKIRSNWNGYALIED---IAVAKDYRKKGVGTALLHKAIEWAKENHF 123

Query: 122 IESLKLDVQVRNTKAIYLYKKYGFRI 147
L L+ Q N A + Y K+ F I
Sbjct: 124 C-GLMLETQDINISACHFYAKHHFII 148


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1536TYPE3IMSPROT320.006 Type III secretion system inner membrane S protein ...
		>TYPE3IMSPROT#Type III secretion system inner membrane S protein

family signature.
Length = 354

Score = 31.7 bits (72), Expect = 0.006
Identities = 19/123 (15%), Positives = 43/123 (34%), Gaps = 8/123 (6%)

Query: 372 LTAVSTAVCFLLSILLLPLVGIVPAAATAPALIVVGVMMVSSFLDVNWSKF--ADALPAF 429
L+ V V L PL+ + A A ++ G ++ + + K +
Sbjct: 72 LSYVVDNVLLEFFYLCFPLLTVAALMAIASHVVQYGFLISGEAIKPDIKKINPIEGAKRI 131

Query: 430 FAA-FFMALCCSISYGIAAAFIFYCLVK-----VVEGKTKDIHPIIWGATFLFIVNFIIL 483
F+ + SI + + + + ++K +++ T I I + +I
Sbjct: 132 FSIKSLVEFLKSILKVVLLSILIWIIIKGNLVTLLQLPTCGIECITPLLGQILRQLMVIC 191

Query: 484 TIL 486
T+
Sbjct: 192 TVG 194


23MGAS10750_Spy1675MGAS10750_Spy1739Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy1675215-2.757754glycerate kinase
MGAS10750_Spy1676215-3.709819Type I restriction-modification system
MGAS10750_Spy1677723-6.335762Type I restriction-modification system
MGAS10750_Spy1678731-7.122386Type I restriction-modification system
MGAS10750_Spy1679735-7.964720phage protein
MGAS10750_Spy1680738-8.018283hypothetical protein
MGAS10750_Spy1681638-7.403392hypothetical protein
MGAS10750_Spy1682437-6.853177phage antirepressor protein
MGAS10750_Spy1683535-7.144990TraG/TraD family
MGAS10750_Spy1684434-7.399598hypothetical protein
MGAS10750_Spy1685534-6.862400hypothetical protein
MGAS10750_Spy1686635-6.535914hypothetical protein
MGAS10750_Spy1687834-7.390508hypothetical protein
MGAS10750_Spy16881034-7.971236hypothetical protein
MGAS10750_Spy1689933-8.618102hypothetical protein
MGAS10750_Spy1690934-8.449988TrsE
MGAS10750_Spy16911036-8.673730TrsE
MGAS10750_Spy16921036-8.669475NlpC/P60 family protein
MGAS10750_Spy16931135-7.442049hypothetical protein
MGAS10750_Spy16941035-7.441383surface protein
MGAS10750_Spy16951035-6.988388hypothetical protein
MGAS10750_Spy1696932-6.739278DNA topoisomerase III
MGAS10750_Spy1697729-5.957265Type II restriction-modification system
MGAS10750_Spy1698728-5.910071Superfamily II DNA and RNA helicase
MGAS10750_Spy1699021-5.687663hypothetical protein
MGAS10750_Spy1700119-4.903339TetR family transcriptional regulator
MGAS10750_Spy1701221-4.015381Tetronasin resistance ATP-binding protein
MGAS10750_Spy1702320-4.141276Tetronasin resistance transmembrane protein
MGAS10750_Spy1704220-6.869227hypothetical protein
MGAS10750_Spy1703121-7.059549rRNA adenine N-6-methyltransferase
MGAS10750_Spy1705222-6.810028spectinomycin phosphotransferase
MGAS10750_Spy1706224-7.542097Cytidine deaminase
MGAS10750_Spy1707225-7.945546Zn-dependent hydrolase
MGAS10750_Spy1708226-8.582867Relaxase
MGAS10750_Spy1709228-8.085983Reverse transcriptase / RNA maturase /
MGAS10750_Spy1710331-8.116382Relaxase
MGAS10750_Spy1711431-8.403163hypothetical protein
MGAS10750_Spy1712532-8.269767RhuM
MGAS10750_Spy1713833-8.953719hypothetical protein
MGAS10750_Spy1714934-8.832587Cro/CI family transcriptional regulator
MGAS10750_Spy1715730-8.116132hypothetical protein
MGAS10750_Spy1716630-8.238149hypothetical protein
MGAS10750_Spy1717630-8.122939Site-specific recombinase
MGAS10750_Spy1718527-8.297284Site-specific recombinase
MGAS10750_Spy1719323-7.841125Site-specific recombinase
MGAS10750_Spy1720221-7.434999Type I restriction-modification system
MGAS10750_Spy1721525-8.471021hypothetical protein
MGAS10750_Spy1722624-8.383031transcriptional regulatory protein degU
MGAS10750_Spy1723524-8.350688Sensory transduction protein kinase
MGAS10750_Spy1724418-7.031310ABC transporter permease
MGAS10750_Spy1725216-5.489756ABC transporter ATP-binding protein
MGAS10750_Spy1726215-5.291147lantibiotic processing peptidase / lantibiotic
MGAS10750_Spy1727017-3.797701serine/threoninedehydratase / Lanthionine
MGAS10750_Spy1728124-1.295511lantibiotic salivaricin A
MGAS10750_Spy1729125-1.2124656-phospho-beta-galactosidase
MGAS10750_Spy1730127-1.213684PTS system, lactose-specific IIBC component
MGAS10750_Spy1731223-2.311798PTS system, lactose-specific IIA component
MGAS10750_Spy1732222-2.516931tagatose 1,6-diphosphate aldolase
MGAS10750_Spy1733120-3.117729tagatose-6-phosphate kinase
MGAS10750_Spy1734122-3.174349galactose-6-phosphate isomerase subunit LacB
MGAS10750_Spy1735324-1.956560galactose-6-phosphate isomerase subunit LacA
MGAS10750_Spy1736431-1.271383Lactose phosphotransferase system repressor
MGAS10750_Spy17375360.649603DNA-damage-inducible protein J
MGAS10750_Spy17381302.048805hypothetical protein
MGAS10750_Spy17390243.316341DNA integration/recombination/inversion protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1680INTIMIN300.011 Intimin signature.
		>INTIMIN#Intimin signature.

Length = 939

Score = 30.0 bits (67), Expect = 0.011
Identities = 24/90 (26%), Positives = 39/90 (43%), Gaps = 15/90 (16%)

Query: 171 NLSNIPLLILD-----DLGIERDTSYAREQVYNI-------INSRYLKGRPTIFTTNLSL 218
N + IPL+ + G E D Y+ + Y I +Y+ T+ + L
Sbjct: 378 NYTPIPLVTMGIDYRHGTGNENDLLYSMQFRYQFDKPWSQQIEPQYVNELRTLSGSRYDL 437

Query: 219 EIIQNPNIDLEYQRIYSRILEMTIPVKVTG 248
+ +N NI LEY++ IL + IP + G
Sbjct: 438 -VQRNNNIILEYKK--QDILSLNIPHDING 464


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1692GPOSANCHOR330.007 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 32.7 bits (74), Expect = 0.007
Identities = 32/301 (10%), Positives = 77/301 (25%), Gaps = 16/301 (5%)

Query: 63 AKDQKQDKLKDFQKAKNKERIRKEVLDNKNKAEETKQTNLEIRTDESYKLDEELDVDIKK 122
A + D L+ Q+ +K I L KN L+ DE + ++K
Sbjct: 44 ATRSQTDTLEKVQERADKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLRK 103

Query: 123 VNFDSENSRNINSNKLTTDDISAKAQPISNKKSSSKRQVLKNYENKFIHSKDKFQDKINE 182
+ + KA + + K +
Sbjct: 104 NDKSLSEKASKIQELEARKADLEKALEGAMNF---STADSAKIKTLEAEKAALAARKADL 160

Query: 183 RESKRIHTSEDKPIEAKKSKRIYRKDKLVKDEVSKNESNANIDKKQKQKLYQEKRFRDKE 242
++ + AK + + E + E ++ + + E
Sbjct: 161 EKALEGAMNFSTADSAKIKTL---EAEKAALEARQAELEKALEGAMNFSTADSAKIKTLE 217

Query: 243 KISKEIDKESKLSEVDTDKTFDNPEFKDNNLEFIKDEKETSLKPSEQKKVNKKKTYYKR- 301
+ E + + ++ + E E + + Q ++ K
Sbjct: 218 AEKAALAARKADLEKALEGAMN--FSTADSAKIKTLEAEKAALEARQAELEKALEGAMNF 275

Query: 302 ---KNYESDKFTRKKIDDLKNESKKVSTKD----SKKAQDVKDFISDKKIGELEKSKSKL 354
+ + +K ++ ++++ S + +LE KL
Sbjct: 276 STADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKL 335

Query: 355 K 355
+
Sbjct: 336 E 336


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1694GPOSANCHOR761e-16 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 76.3 bits (187), Expect = 1e-16
Identities = 54/312 (17%), Positives = 116/312 (37%), Gaps = 20/312 (6%)

Query: 292 DEKDNKIDDLTKNIKDLENQIKDLNDKKQEDQSKIDELKEKLESCKDNGEKLKQEKAKLE 351
+ D + + I++LE + DL + + K+++ + L KA LE
Sbjct: 102 RKNDKSLSEKASKIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLE 161

Query: 352 EEIRNKDNKIAQLNKEIEDLKNSNNDELIAEITQLKDELKRLQDENEKLKEDYSSTKWEL 411
+ + N + +I+ L+ L A +L+ L+ + + + + E
Sbjct: 162 KALEGAMNFSTADSAKIKTLEAEKA-ALEARQAELEKALEGAMNFSTADSAKIKTLEAEK 220

Query: 412 EAEKEKTDKNENKIKEMQEKLESLEGELAKKTKEIGDKDNRIKDLEKALDEKDTKIKDLE 471
A + E ++ + ++ E + R +LEKAL+
Sbjct: 221 AALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADS 280

Query: 472 SKKKETENSKSECFKKIEELQKAIDSLKESSENTKKELEEKIKGLEEKQKSSEEEIKKLK 531
+K K E K +E + ++ + ++ L + E +K E E +KL+
Sbjct: 281 AKIKTLEAEK----AALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLE 336

Query: 532 EELD-------------KKIEEAKKLIEEANKKAKEELEKQTKDDKDKNLNQDLSKKLDE 578
E+ EAKK +E ++K +E + + + ++L +DL +
Sbjct: 337 EQNKISEASRQSLRRDLDASREAKKQLEAEHQKLEE--QNKISEASRQSLRRDLDASREA 394

Query: 579 LLKLQKENKEKK 590
+++K +E
Sbjct: 395 KKQVEKALEEAN 406



Score = 70.9 bits (173), Expect = 1e-14
Identities = 40/300 (13%), Positives = 111/300 (37%), Gaps = 9/300 (3%)

Query: 319 KQEDQSKIDELKEKLESCKDNGEKLKQEKAKLEEEIRNKDNKIAQLNKEIEDLKNSNNDE 378
+ +++++E+ + + LK + + L + + +L +E+ + K
Sbjct: 45 TRSQTDTLEKVQERADKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLRKN 104

Query: 379 ---------LIAEITQLKDELKRLQDENEKLKEDYSSTKWELEAEKEKTDKNENKIKEMQ 429
I E+ K +L++ + S+ LEAEK + +++
Sbjct: 105 DKSLSEKASKIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKAL 164

Query: 430 EKLESLEGELAKKTKEIGDKDNRIKDLEKALDEKDTKIKDLESKKKETENSKSECFKKIE 489
E + + K K + + ++ + L++ + + + +
Sbjct: 165 EGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALA 224

Query: 490 ELQKAIDSLKESSENTKKELEEKIKGLEEKQKSSEEEIKKLKEELDKKIEEAKKLIEEAN 549
+ ++ E + N KIK LE ++ + E +L++ L+ + + +
Sbjct: 225 ARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIK 284

Query: 550 KKAKEELEKQTKDDKDKNLNQDLSKKLDELLKLQKENKEKKEDKKSQDKKWDELLKADDK 609
E+ + + ++ +Q L+ L + ++E K+ +++ +K +E K +
Sbjct: 285 TLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEA 344



Score = 62.0 bits (150), Expect = 6e-12
Identities = 60/308 (19%), Positives = 121/308 (39%), Gaps = 7/308 (2%)

Query: 289 QDIDEKDNKIDDLTKNIKDLENQIKDLNDKKQEDQSKIDELKEKLESCKDNGEKLKQEKA 348
KI L L + DL + + K+++ + L+ +A
Sbjct: 204 NFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQA 263

Query: 349 KLEEEIRNKDNKIAQLNKEIEDLKNSNNDELIAEITQLKDELKRLQDENEKLKEDYSSTK 408
+LE+ + N + +I+ L+ + L AE L+ + + L + L+ D +++
Sbjct: 264 ELEKALEGAMNFSTADSAKIKTLE-AEKAALEAEKADLEHQSQVLNANRQSLRRDLDASR 322

Query: 409 WELEAEKEKTDKNENKIKEMQEKLESLEGELAKKTKEIGDKDNRIKDLEKALDEKDTKIK 468
+ + + K E + K + +SL +L + + + LE+ + +
Sbjct: 323 EAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQ 382

Query: 469 DLESKKKETENSKSECFKKIEELQKAIDSLKESSENTKKELEEKIKGLEEKQKSSEEEIK 528
L + +K + K +EE + +L++ ++ ++ + K E Q E E K
Sbjct: 383 SLRRDLDASREAKKQVEKALEEANSKLAALEKLNKELEESKKLTEKEKAELQAKLEAEAK 442

Query: 529 KLKEELDKKIEEAKKLIEEANKKAKEELEKQTKDDKDKNLNQDLSKKLDELLKLQKENKE 588
LKE+L K+ EE KL +A + + QT D K N + + +NK
Sbjct: 443 ALKEKLAKQAEELAKL------RAGKASDSQTPDAKPGNKAVPGKGQAPQAGTKPNQNKA 496

Query: 589 KKEDKKSQ 596
++ K Q
Sbjct: 497 PMKETKRQ 504



Score = 52.0 bits (124), Expect = 7e-09
Identities = 31/235 (13%), Positives = 74/235 (31%), Gaps = 11/235 (4%)

Query: 410 ELEAEKEKTDKNENKIKEMQEKLESLEGELAKKTKEIGDKDNRIKDLEKALDEKDTKIKD 469
LE +E+ DK E + ++ K L + + + ++ L + D + +
Sbjct: 51 TLEKVQERADKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLRKNDKSLSE 110

Query: 470 LESKKKETENSKSECFKKIEELQKAIDSLKESSENTKKELEEKIKGLEEKQKSSEEEIKK 529
SK +E E K++ K +E + + LE + L ++ E+ ++
Sbjct: 111 KASKIQELEARKADLEKALEGAMNFSTADSAKIKT----LEAEKAALAARKADLEKALEG 166

Query: 530 LKEELD------KKIEEAKKLIEEANKKAKEELEKQTKDDKD-KNLNQDLSKKLDELLKL 582
K +E K +E + ++ LE + L + L
Sbjct: 167 AMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAAR 226

Query: 583 QKENKEKKEDKKSQDKKWDELLKADDKNILNQFDLNKMKKQEEQQNKKQVKDEKE 637
+ + ++ E + +K + ++ + +
Sbjct: 227 KADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSA 281


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1700HTHTETR627e-14 TetR bacterial regulatory protein HTH signature.
		>HTHTETR#TetR bacterial regulatory protein HTH signature.

Length = 215

Score = 61.6 bits (149), Expect = 7e-14
Identities = 31/183 (16%), Positives = 68/183 (37%), Gaps = 8/183 (4%)

Query: 15 EKQKQIINAAIKEFVRNGFEKASTNEIVKRANISKGSLFNYFNSKKDLYLYLIE-YSSKA 73
E ++ I++ A++ F + G S EI K A +++G+++ +F K DL+ + E S
Sbjct: 11 ETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNI 70

Query: 74 IVNLNEEIDLSETDLFKRIERVALQKFYVQQKYPQAFEFLASTKQE-ESVEVKDIIKQRL 132
E D + + + + + + E V +++Q
Sbjct: 71 GELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQAQ 130

Query: 133 NPIYNQAINK----LYKDIDYSKFREGVDIEKAIEILNWTMFGVGEKGL--KELFTFDDI 186
+ ++ ++ L I+ + +A I+ + G+ E L + F
Sbjct: 131 RNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMENWLFAPQSFDLKKE 190

Query: 187 GRF 189
R
Sbjct: 191 ARD 193


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1710FbpA_PF05833260.035 Fibronectin-binding protein
		>FbpA_PF05833#Fibronectin-binding protein

Length = 577

Score = 26.4 bits (58), Expect = 0.035
Identities = 13/70 (18%), Positives = 25/70 (35%), Gaps = 9/70 (12%)

Query: 3 ITKIH-PIKSTLNLAIDYITNSEKTDEKVLVSTFKCHPSTAHIQFLKTREDNDTKGTVLA 61
I K++ P K + L I + K+L+S + I + N K +
Sbjct: 24 IDKVNQPEKDEIILNI----RKGRLSFKLLIS---SSSNYPRIHLTDLTKPNPIKAPMFC 76

Query: 62 RHLIQSFLPG 71
L + ++
Sbjct: 77 MVL-RKYISN 85


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1719GPOSANCHOR310.013 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 30.8 bits (69), Expect = 0.013
Identities = 19/93 (20%), Positives = 41/93 (44%)

Query: 376 KNSRAGSLEEQVFEAIKEKYGLEDPIKDEKVKVKPMEKSIEDLEAKKMQSFEKYKLGKMN 435
+ +LE + E K G + + K+K +E LEA+K + ++ N
Sbjct: 251 LEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNAN 310

Query: 436 RQKFIDLKNSIDEELQAIKEKIQKAKEEKEVID 468
RQ ++ E + ++ + QK +E+ ++ +
Sbjct: 311 RQSLRRDLDASREAKKQLEAEHQKLEEQNKISE 343


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1722HTHFIS463e-08 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 46.0 bits (109), Expect = 3e-08
Identities = 21/118 (17%), Positives = 51/118 (43%), Gaps = 6/118 (5%)

Query: 2 KILLIDDHRLFAKSIQLLFQQYD-EVDVIDTITSHFNDVTIDLSKYDIILLDINLTNISK 60
IL+ DD + + +V + + + + D+++ D+ +
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWI--AAGDGDLVVTDVVM---PD 59

Query: 61 ENGLEIAKELIQSTPHLKVVMLTGYVKSIYRERAKKVGAYGFVDKNIDPKQLISILKK 118
EN ++ + ++ P L V++++ + +A + GAY ++ K D +LI I+ +
Sbjct: 60 ENAFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGR 117


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1736ARGREPRESSOR300.005 Bacterial arginine repressor signature.
		>ARGREPRESSOR#Bacterial arginine repressor signature.

Length = 149

Score = 29.8 bits (67), Expect = 0.005
Identities = 21/85 (24%), Positives = 38/85 (44%), Gaps = 11/85 (12%)

Query: 1 MKKKERHEKILDILKVDGFIKVKDIIDEM-----NISDMTARRDLDTLADKGLL-IRTHG 54
M K +RH KI +I+ + +++D + N++ T RD+ L L+ + T+
Sbjct: 1 MNKGQRHIKIREIITANEIETQDELVDILKKDGYNVTQATVSRDIKEL---HLVKVPTNN 57

Query: 55 GAQYLDYSSAKDEGHEKTHTEKKVL 79
G+ YS D+ K+ L
Sbjct: 58 GSYK--YSLPADQRFNPLSKLKRSL 80


24MGAS10750_Spy1749MGAS10750_Spy1792Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy1749-1153.328274cysteinyl-tRNA synthetase
MGAS10750_Spy17500173.436960hypothetical protein
MGAS10750_Spy1751-1194.410916hypothetical protein
MGAS10750_Spy1752-1194.183132serineacetyltransferase
MGAS10750_Spy1753-1173.485342hypothetical protein
MGAS10750_Spy1754-1183.452184polynucleotide phosphorylase/polyadenylase
MGAS10750_Spy17550182.527164translaldolase
MGAS10750_Spy1756-1192.555258PTS system ascorbate-specific transporter
MGAS10750_Spy1757-2211.111208PTS system, IIB component
MGAS10750_Spy1758-1201.376563transcription antiterminator, BglG family / PTS
MGAS10750_Spy17590211.598834hypothetical protein
MGAS10750_Spy17600171.84376930S ribosomal protein S15
MGAS10750_Spy1761-2183.707411hypothetical protein
MGAS10750_Spy1762-2173.994831transcriptional regulator
MGAS10750_Spy1763-2153.818015peptide deformylase
MGAS10750_Spy1764-1153.698620NADPH-dependent FMN reductase family protein
MGAS10750_Spy17650163.550815MarR family transcriptional regulator
MGAS10750_Spy17660173.582310DNA polymerase III PolC
MGAS10750_Spy1767-2162.813785prolyl-tRNA synthetase
MGAS10750_Spy1768-2152.974920Membrane endopeptidase, M50 family
MGAS10750_Spy1769-2153.112056phosphatidate cytidylyltransferase
MGAS10750_Spy1770-2163.741361undecaprenyl pyrophosphate synthase
MGAS10750_Spy1771-2163.983444preprotein translocase subunit YajC
MGAS10750_Spy1772-2174.339425Thioredoxin
MGAS10750_Spy1774-2173.951019Pullulanase
MGAS10750_Spy1773-2203.795708hypothetical protein
MGAS10750_Spy1775-2224.448216glucan 1,6-alpha-glucosidase
MGAS10750_Spy1776-1215.591737Multiple sugar transport ATP-binding protein
MGAS10750_Spy1777-2246.007073hypothetical protein
MGAS10750_Spy1778-3245.758943Streptokinase
MGAS10750_Spy1779-1226.366075D-tyrosyl-tRNA(Tyr) deacylase
MGAS10750_Spy1780-1226.322888GTP pyrophosphokinase /
MGAS10750_Spy17810216.496634Collagen-like surface protein
MGAS10750_Spy17820194.930095flavoprotein NrdI
MGAS10750_Spy17830185.758891endonuclease/exonuclease/phosphatase family
MGAS10750_Spy17840206.005309PTS system, glucose-specific IIABC component
MGAS10750_Spy17850246.19666716S ribosomal RNA methyltransferase RsmE
MGAS10750_Spy1786-1235.986492ribosomal protein L11 methyltransferase
MGAS10750_Spy1787-1245.375362hypothetical protein
MGAS10750_Spy1788-1245.209069Amidase family protein
MGAS10750_Spy1789-3232.995456Para-aminobenzoate synthetase component I /
MGAS10750_Spy1790017-0.843404anthranilate synthase component II
MGAS10750_Spy1791016-2.248103recombination factor protein RarA
MGAS10750_Spy1792-214-3.106460*acetyltransferase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1768PF04605300.009 Virulence-associated protein D (VapD)
		>PF04605#Virulence-associated protein D (VapD)

Length = 125

Score = 29.8 bits (67), Expect = 0.009
Identities = 8/44 (18%), Positives = 17/44 (38%), Gaps = 2/44 (4%)

Query: 227 INGYKVTSWNDLTEAV-DLATRD-LGPSQTIKVTYKSHQRLKTV 268
+ ++ L E + DL +D + +Q+LK +
Sbjct: 80 FDITEIGEQYSLKETIQDLCAKDFHQKLKEFTEKTPKNQKLKDL 123


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1774GPOSANCHOR350.003 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 34.7 bits (79), Expect = 0.003
Identities = 24/96 (25%), Positives = 38/96 (39%), Gaps = 5/96 (5%)

Query: 1066 QAGVTAIAKPKGVQFTKEGLTIDSLTALVLKVSSKPADPSQKKSQTGNHQTKTPDGSKDL 1125
QA + A AK + K+ + L A S P K+ G Q +
Sbjct: 434 QAKLEAEAKALKEKLAKQAEELAKLRAGKASDSQTPDAKPGNKAVPGKGQAPQAGTKPNQ 493

Query: 1126 DKSLMTRPKRAQTNQKLPKTGEASSKGLLAAGVALL 1161
+K+ M KR +LP TGE ++ AA + ++
Sbjct: 494 NKAPMKETKR-----QLPSTGETANPFFTAAALTVM 524


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1776PF05272320.003 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 32.4 bits (73), Expect = 0.003
Identities = 14/56 (25%), Positives = 20/56 (35%), Gaps = 9/56 (16%)

Query: 34 IVFVGPSGCGKSTTLPMIAGLEDISEGELKIGGEVVNDKSPKDRDIAMVFQNYALY 89
+V G G GKST + + GL+ S+ IG +D Y
Sbjct: 599 VVLEGTGGIGKSTLINTLVGLDFFSDTHFDIG---------TGKDSYEQIAGIVAY 645


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1777HTHFIS347e-04 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 34.0 bits (78), Expect = 7e-04
Identities = 10/30 (33%), Positives = 19/30 (63%)

Query: 243 ALWSEHGNLVQTAQRLYIHRNSLQYKLDKF 272
AL + GN ++ A L ++RN+L+ K+ +
Sbjct: 444 ALTATRGNQIKAADLLGLNRNTLRKKIREL 473


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1778STREPKINASE7890.0 Streptococcus streptokinase protein signature.
		>STREPKINASE#Streptococcus streptokinase protein signature.

Length = 440

Score = 789 bits (2039), Expect = 0.0
Identities = 374/440 (85%), Positives = 398/440 (90%)

Query: 1 MKNYLSFGMFALLFALTFGTVKPVQAIAGPEWLLDRPSVNNIQLVVSVAGTVEGTNQEIS 60
MKNYLSFGMFALLFALTFGTV VQAIAGPEWLLDRPSVNN QLVVSVAGTVEGTNQ+IS
Sbjct: 1 MKNYLSFGMFALLFALTFGTVNSVQAIAGPEWLLDRPSVNNSQLVVSVAGTVEGTNQDIS 60

Query: 61 LKFFEIDLTSGPAQGGKTEQGLSPKSKPFATNKGAMPHKLEKADLLKAIQEQLIANVHSN 120
LKFFEIDLTS PA GGKTEQGLSPKSKPFAT+ GAM HKLEKADLLKAIQEQLIANVHSN
Sbjct: 61 LKFFEIDLTSRPAHGGKTEQGLSPKSKPFATDSGAMSHKLEKADLLKAIQEQLIANVHSN 120

Query: 121 DGYFEVIDFASDATITDRNGKVYFADRDDSVTLPTQPVQEFLLSGHVRVRPYQPKAVHNS 180
D YFEVIDFASDATITDRNGKVYFAD+D SVTLPTQPVQEFLLSGHVRVRPY+ K + N
Sbjct: 121 DDYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLSGHVRVRPYKEKPIQNQ 180

Query: 181 AERVNVNYEVSFVSETGDLDFTPLLRNQYQLTTLAVGDSLSSQELAAIAQFILSKKYPDY 240
A+ V+V Y V F D DF P L++ L TLA+GD+++SQEL A AQ IL+K +P Y
Sbjct: 181 AKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKNHPGY 240

Query: 241 IITKRDSSIVTHDNDIFRTILPMDQEFTYHIKDREQAYKANSKTGIVEKTNNTDLISEKY 300
I +RDSSIVTHDNDIFRTILPMDQEFTY +K+REQAY+ N K+G+ E+ NNTDLISEKY
Sbjct: 241 TIYERDSSIVTHDNDIFRTILPMDQEFTYRVKNREQAYRINKKSGLNEEINNTDLISEKY 300

Query: 301 YVLKKGEKPYDPFDRSHLKLFTINYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAK 360
YVLKKGEKPYDPFDRSHLKLFTI YVDV+TNELLKSEQLLTASERNLDFRDLYDPRDKAK
Sbjct: 301 YVLKKGEKPYDPFDRSHLKLFTIKYVDVDTNELLKSEQLLTASERNLDFRDLYDPRDKAK 360

Query: 361 LLYNNLDAFGIMDYTLTGKVEDNHNDTNRIITVYMGKRPEGENASYHLAYDKDRYTEEER 420
LLYNNLDAFGIMDYTLTGKVEDNH+DTNRIITVYMGKRPEGENASYHLAYDKDRYTEEER
Sbjct: 361 LLYNNLDAFGIMDYTLTGKVEDNHDDTNRIITVYMGKRPEGENASYHLAYDKDRYTEEER 420

Query: 421 EVYSYLRYTGTPIPDNPNDK 440
EVYSYLRYTGTPIPDNPNDK
Sbjct: 421 EVYSYLRYTGTPIPDNPNDK 440


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1781GPOSANCHOR635e-13 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 63.2 bits (153), Expect = 5e-13
Identities = 42/124 (33%), Positives = 53/124 (42%), Gaps = 3/124 (2%)

Query: 272 EKAPEKSPEVTPTPETPEQP---GEKAPEKSPEVTPTPETPEQPGEKAPEKSKEVTPAPE 328
K E+S ++T + Q E K E + KA +
Sbjct: 416 NKELEESKKLTEKEKAELQAKLEAEAKALKEKLAKQAEELAKLRAGKASDSQTPDAKPGN 475

Query: 329 KPADKEANQTPERRNGNMAKTPVANNHRRLPATGEQANPFFTAAAVAVMTTAGVLAVTKR 388
K + N K P+ R+LP+TGE ANPFFTAAA+ VM TAGV AV KR
Sbjct: 476 KAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETANPFFTAAALTVMATAGVAAVVKR 535

Query: 389 KENN 392
KE N
Sbjct: 536 KEEN 539


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1791HTHFIS340.001 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 33.7 bits (77), Expect = 0.001
Identities = 28/155 (18%), Positives = 46/155 (29%), Gaps = 38/155 (24%)

Query: 8 RMRPKTISEVIGQKHLVGEGKIIRRMVE-----ANRLSSMILYGPPGIGKTSIASAIAGT 62
R K + LVG ++ + ++++ G G GK +A A+
Sbjct: 124 RRPSKLEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVARALHDY 183

Query: 63 TRYAFRTF--------------------------NATIDSKKRLQEIAEEAKFSGGLVLL 96
+ F A S R ++ + G L
Sbjct: 184 GKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQTRSTGRFEQ-------AEGGTLF 236

Query: 97 LDEIHRLDKTKQDFLLPLLENGTIIMIGATTENPF 131
LDEI + Q LL +L+ G +G T
Sbjct: 237 LDEIGDMPMDAQTRLLRVLQQGEYTTVGGRTPIRS 271


25MGAS10750_Spy1804MGAS10750_Spy1838Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy18044162.276914Streptococcal histidine triad protein
MGAS10750_Spy18056192.342967Laminin-binding surface protein
MGAS10750_Spy18066181.632644Fibronectin-binding protein
MGAS10750_Spy18076190.992033C5A peptidase precursor
MGAS10750_Spy18081021-0.283637M protein
MGAS10750_Spy18096211.250405M protein
MGAS10750_Spy18103210.986402M protein
MGAS10750_Spy18112220.712051trans-acting positive regulator Mry
MGAS10750_Spy18120241.244499hypothetical protein
MGAS10750_Spy1813-1231.409915Immunogenic protein
MGAS10750_Spy1814-1221.361881Immunogenic secreted protein
MGAS10750_Spy1815-122-0.072813two-component system histidine kinase
MGAS10750_Spy1816-2220.138063two-component response regulator
MGAS10750_Spy1817-1242.356783ABC transporter permease
MGAS10750_Spy18181161.967848ABC transporter ATP-binding protein
MGAS10750_Spy18192172.435644periplasmic component of efflux system
MGAS10750_Spy18202192.765084hypothetical protein
MGAS10750_Spy18212202.992654hypothetical protein
MGAS10750_Spy18222203.070565Fibronectin-binding protein
MGAS10750_Spy18232181.483263Fibronectin-binding protein
MGAS10750_Spy18242312.698948hypothetical protein
MGAS10750_Spy18252331.354237foldase PrsA
MGAS10750_Spy1826020-1.456374hypothetical protein
MGAS10750_Spy1827020-1.008732Streptopain precursor
MGAS10750_Spy1828020-1.522563Streptopain precursor
MGAS10750_Spy1829-119-1.243927hypothetical protein
MGAS10750_Spy18300170.979835hypothetical protein
MGAS10750_Spy18310161.767859transcriptional regulator
MGAS10750_Spy1832-1244.691682deoxyribonuclease precursor
MGAS10750_Spy18332254.727895hypothetical protein
MGAS10750_Spy18343244.784851Low temperature requirement C protein
MGAS10750_Spy18353244.497500glycerol dehydrogenase
MGAS10750_Spy18361223.911097fructose-6-phosphate aldolase
MGAS10750_Spy18370223.785790Formate acetyltransferase
MGAS10750_Spy18382192.526710PTS system, cellobiose-specific IIC component
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1805ADHESNFAMILY2473e-83 Adhesin family signature.
		>ADHESNFAMILY#Adhesin family signature.

Length = 309

Score = 247 bits (633), Expect = 3e-83
Identities = 82/323 (25%), Positives = 143/323 (44%), Gaps = 34/323 (10%)

Query: 1 MKKGFFLMAMAVSLVMIAGCDKSANPKQPTQGMSVVTSFYPMYAMTKEVSGDLNDVR-MI 59
MKK L+ + +S +++ C Q + VV + + +TK ++GD D+ ++
Sbjct: 1 MKKLGTLLVLFLSAIILVACASGKKDTTSGQKLKVVATNSIIADITKNIAGDKIDLHSIV 60

Query: 60 QSGAGIHSFEPSVNDVAAIYDADLFVYHSHTLE----AWARDLDPNLKKSKVDVFEASKP 115
G H +EP DV +ADL Y+ LE AW L N KK++ + A
Sbjct: 61 PIGQDPHEYEPLPEDVKKTSEADLIFYNGINLETGGNAWFTKLVENAKKTENKDYFA--- 117

Query: 116 LTLDRVKGLEDMEVTQGIDPATLY--------DPHTWTDPVLAGEEAVNIAKELGRLDPK 167
V+ G+D L DPH W + A NIAK+L DP
Sbjct: 118 -------------VSDGVDVIYLEGQNEKGKEDPHAWLNLENGIIFAKNIAKQLSAKDPN 164

Query: 168 HKDSYTKKAKAFKKEAEQLTEEYTQKFKKVR--SKTFVTQHTAFSYLAKRFGLKQLGISG 225
+K+ Y K K + + ++L +E KF K+ K VT AF Y +K +G+ I
Sbjct: 165 NKEFYEKNLKEYTDKLDKLDKESKDKFNKIPAEKKLIVTSEGAFKYFSKAYGVPSAYIWE 224

Query: 226 ISPEQEPSPRQLKEIQDFVKEYNVKTIFAEDNVNPKIAHAIAKSTGAKVKT---LSPLEA 282
I+ E+E +P Q+K + + +++ V ++F E +V+ + +++ T + +
Sbjct: 225 INTEEEGTPEQIKTLVEKLRQTKVPSLFVESSVDDRPMKTVSQDTNIPIYAQIFTDSIAE 284

Query: 283 APSGNKTYLENLRANLEVLYQQL 305
+Y ++ NL+ + + L
Sbjct: 285 QGKEGDSYYSMMKYNLDKIAEGL 307


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1806IGASERPTASE423e-06 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 41.6 bits (97), Expect = 3e-06
Identities = 37/249 (14%), Positives = 76/249 (30%), Gaps = 27/249 (10%)

Query: 37 AVDSIPPISLTQRTPATTSEKWHHIDDKGSIPLGISLEAAKKDFKEEVEKSRLSEEQKQT 96
VD P TP+ T+E ++ + ++ E + +E Q
Sbjct: 1019 RVDEAPVPPPAPATPSETTET-------------VAENSKQESKTVEKNEQDATETTAQ- 1064

Query: 97 YNQKIDAETDKDELLSTYHRDYLTAVKNLPTSTEPVEASVQETQASVSDSMVTGDSTSVT 156
+ A+ K + + + + + T+ E T + V + T
Sbjct: 1065 --NREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETKETATVEKEEKAKVETEKTQ-- 1120

Query: 157 ADSPKESPVAPASSPESEDSSVASSEETSSPETPVAPETPEEPAAPSPSPESEEPSVAAS 216
+ V SP+ E S + + E +EP + + + E +
Sbjct: 1121 ----EVPKVTSQVSPKQEQSETVQPQAEPARE-NDPTVNIKEPQSQTNTTADTEQPAKET 1175

Query: 217 SEETPTPSTPEEPA----APSPSPESEEPSVAASSEETPTPSTPEEPAAPSPSPESEDSS 272
S P T + +PE+ P+ + + + + P+ S +
Sbjct: 1176 SSNVEQPVTESTTVNTGNSVVENPENTTPATTQPTVNSESSNKPKNRHRRSVRSVPHNVE 1235

Query: 273 VAATTSPSP 281
A T+S
Sbjct: 1236 PATTSSNDR 1244



Score = 35.4 bits (81), Expect = 2e-04
Identities = 36/195 (18%), Positives = 72/195 (36%), Gaps = 13/195 (6%)

Query: 90 SEEQKQTYNQKIDAETDKDELLSTYHRDYLTAVKNLPTSTEPVEASVQE-TQASVSDSMV 148
S ++D +T T +N ++ VE + Q+ T+ + + V
Sbjct: 1009 SVPSNNEEIARVDEAPVPPPAPATPSETTETVAENSKQESKTVEKNEQDATETTAQNREV 1068

Query: 149 TGDSTSVTADSPKESPVAPASSPESEDSSVASSEETSSPETPVAPETPEEPAAPSPSPES 208
++ S + + + VA + S E++++ ++ET++ E EE A
Sbjct: 1069 AKEAKSNVKANTQTNEVAQSGS-ETKETQTTETKETATVEK-------EEKAKVETEKTQ 1120

Query: 209 EEPSVAASSEETPTPSTPEEPAAPSPSPESEEPSVAASSEETPTPSTPEEPA----APSP 264
E P V + S +P A ++ +T T + E+PA +
Sbjct: 1121 EVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQTNTTADTEQPAKETSSNVE 1180

Query: 265 SPESEDSSVAATTSP 279
P +E ++V S
Sbjct: 1181 QPVTESTTVNTGNSV 1195



Score = 28.5 bits (63), Expect = 0.033
Identities = 15/75 (20%), Positives = 27/75 (36%), Gaps = 5/75 (6%)

Query: 203 SPSPESEEPSVAASSEETPTPSTPEEPAAPSPSPESEEPSVAASSEETPTPSTPEEPAAP 262
+P E +V ++ TP + P+ PS + E +A E P P P+
Sbjct: 982 NPEVEKRNQTVDTTNITTPNNIQADVPSVPSNNEE-----IARVDEAPVPPPAPATPSET 1036

Query: 263 SPSPESEDSSVAATT 277
+ + + T
Sbjct: 1037 TETVAENSKQESKTV 1051


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1807SUBTILISIN1073e-27 Subtilisin serine protease family (S8) signature.
		>SUBTILISIN#Subtilisin serine protease family (S8) signature.

Length = 326

Score = 107 bits (269), Expect = 3e-27
Identities = 50/226 (22%), Positives = 85/226 (37%), Gaps = 47/226 (20%)

Query: 118 KAGKGAGTVVAVIDAGFDKNHEAWRLTDKSKARYQSKEDLEKAKKDHGITYGEWVNDKVA 177
+G G VAV+D G D +H DL KA+ G + +
Sbjct: 36 NQTRGRGVKVAVLDTGCDADHP----------------DL-KARIIGGRNFTDDDEGDPE 78

Query: 178 YYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLA 237
+ DY+ HGTHV+G ++ + G PEA LL+++V G
Sbjct: 79 IFKDYNG---------HGTHVAGTIAATENE-----NGVVGVAPEADLLIIKVLNKQGSG 124

Query: 238 DYARNYAQAIRDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGND 297
Y Q I A+ +I+MS G E +A A + + ++ +AGN+
Sbjct: 125 QYD-WIIQGIYYAIEQKVDIISMSLGGPED-----VPELHEAVKKAVASQILVMCAAGNE 178

Query: 298 SSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETAT 343
+T +G P + ++V + + D+ +E +
Sbjct: 179 GDGDDRT----------DELGYPGCYNEVISVGAINFDRHASEFSN 214



Score = 79.9 bits (197), Expect = 5e-18
Identities = 37/139 (26%), Positives = 58/139 (41%), Gaps = 22/139 (15%)

Query: 458 NATPKVLPTASGTK---LSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSM 514
+V+ + S FS+ + D+ APG+DILS+V KYA SGTSM
Sbjct: 192 GCYNEVISVGAINFDRHASEFSNSNN------EVDLVAPGEDILSTVPGGKYATFSGTSM 245

Query: 515 SAPLVAGIMGL-LQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGA 573
+ P VAG + L Q + D+T E L+ L + SP+ +G
Sbjct: 246 ATPHVAGALALIKQLANASFERDLTEPE----LYAQLIKRTIPLGN-------SPKMEGN 294

Query: 574 GAVDAKKASA-ATMYVTDK 591
G + + ++ T +
Sbjct: 295 GLLYLTAVEELSRIFDTQR 313


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1808GPOSANCHOR1172e-31 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 117 bits (293), Expect = 2e-31
Identities = 151/314 (48%), Positives = 202/314 (64%), Gaps = 20/314 (6%)

Query: 28 KAKYDALRDENTGLRGDRTKLLKKLEEEQEKSKNLEKQKQELENQALNFHDVIETQEKEK 87
+ + + +T L + + + LEK + N + I+T E EK
Sbjct: 231 EKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEK 290

Query: 88 EDLKTTLAKTTKENEISEASRKGLSSDLEASRAAKKELEAKHQKLEAENKKLTEANQVSE 147
L+ A ++++ A+R+ L DL+ASR AKK+LEA+HQKLE E N++SE
Sbjct: 291 AALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLE-------EQNKISE 343

Query: 148 ASRKGLSNDLEASRAAKKELEAKHQKLEADYQVSETSRKGLSRDLEASREANKKVTSELT 207
ASR+ L DL+ASR AKK+LEA+HQKLE ++SE SR+ L RDL+ASREA K+V L
Sbjct: 344 ASRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQVEKALE 403

Query: 208 QAKAQLSALE-------ESKKLSEKEKAELQAKLDAQGKALKEQLAKQTEELAKLRAEKA 260
+A ++L+ALE ESKKL+EKEKAELQAKL+A+ KALKE+LAKQ EELAKLRA KA
Sbjct: 404 EANSKLAALEKLNKELEESKKLTEKEKAELQAKLEAEAKALKEKLAKQAEELAKLRAGKA 463

Query: 261 AGSKTPATKPANKERSGR--AAQTATRPSQNKG----MRSQLPSTGEAANPFFTAAAATV 314
+ S+TP KP NK G+ A Q T+P+QNK + QLPSTGE ANPFFTAAA TV
Sbjct: 464 SDSQTPDAKPGNKAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETANPFFTAAALTV 523

Query: 315 MVSAGMLALKRKEE 328
M +AG+ A+ +++E
Sbjct: 524 MATAGVAAVVKRKE 537



Score = 52.8 bits (126), Expect = 9e-10
Identities = 51/250 (20%), Positives = 91/250 (36%), Gaps = 11/250 (4%)

Query: 1 MTVLGAGFANQTEVRAEGVKATTNLPEKAKYDALRDENTGLRGDRTKLLKKLEEEQEKSK 60
+TVLGAG T + + + + +++ + L K + +K
Sbjct: 26 LTVLGAGLVVNTNEVSAVATRS----QTDTLEKVQERADKFEIENNTLKLKNSDLSFNNK 81

Query: 61 NLEKQKQELENQALNFHDVIETQEKEKEDLKTTLAKTTKENEISEASRKGLSSDLEASRA 120
L+ EL + + +++ +L++ + + EA + L LE +
Sbjct: 82 ALKDHNDELTEE-------LSNAKEKLRKNDKSLSEKASKIQELEARKADLEKALEGAMN 134

Query: 121 AKKELEAKHQKLEAENKKLTEANQVSEASRKGLSNDLEASRAAKKELEAKHQKLEADYQV 180
AK + LEAE L E + +G N A A K LEA+ LEA
Sbjct: 135 FSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAE 194

Query: 181 SETSRKGLSRDLEASREANKKVTSELTQAKAQLSALEESKKLSEKEKAELQAKLDAQGKA 240
E + +G A K + +E A+ + LE++ + + AK+
Sbjct: 195 LEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAE 254

Query: 241 LKEQLAKQTE 250
A+Q E
Sbjct: 255 KAALEARQAE 264



Score = 40.4 bits (94), Expect = 7e-06
Identities = 50/211 (23%), Positives = 83/211 (39%)

Query: 11 QTEVRAEGVKATTNLPEKAKYDALRDENTGLRGDRTKLLKKLEEEQEKSKNLEKQKQELE 70
+ A+ L G T K++ + + LE ++ ELE
Sbjct: 137 TADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELE 196

Query: 71 NQALNFHDVIETQEKEKEDLKTTLAKTTKENEISEASRKGLSSDLEASRAAKKELEAKHQ 130
+ + + L+ A E + +G + A A K LEA+
Sbjct: 197 KALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKA 256

Query: 131 KLEAENKKLTEANQVSEASRKGLSNDLEASRAAKKELEAKHQKLEADYQVSETSRKGLSR 190
LEA +L +A + + S ++ A K LEA+ LE QV +R+ L R
Sbjct: 257 ALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRR 316

Query: 191 DLEASREANKKVTSELTQAKAQLSALEESKK 221
DL+ASREA K++ +E + + Q E S++
Sbjct: 317 DLDASREAKKQLEAEHQKLEEQNKISEASRQ 347



Score = 37.7 bits (87), Expect = 5e-05
Identities = 51/232 (21%), Positives = 83/232 (35%)

Query: 30 KYDALRDENTGLRGDRTKLLKKLEEEQEKSKNLEKQKQELENQALNFHDVIETQEKEKED 89
K L L + + K K LE +K L + + +E
Sbjct: 114 KIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTA 173

Query: 90 LKTTLAKTTKENEISEASRKGLSSDLEASRAAKKELEAKHQKLEAENKKLTEANQVSEAS 149
+ E EA + L LE + AK + LEAE L E +
Sbjct: 174 DSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKA 233

Query: 150 RKGLSNDLEASRAAKKELEAKHQKLEADYQVSETSRKGLSRDLEASREANKKVTSELTQA 209
+G N A A K LEA+ LEA E + +G A K + +E
Sbjct: 234 LEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAAL 293

Query: 210 KAQLSALEESKKLSEKEKAELQAKLDAQGKALKEQLAKQTEELAKLRAEKAA 261
+A+ + LE ++ + L+ LDA +A K+ A+ + + + +A+
Sbjct: 294 EAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEAS 345



Score = 37.7 bits (87), Expect = 5e-05
Identities = 51/238 (21%), Positives = 86/238 (36%), Gaps = 10/238 (4%)

Query: 33 ALRDENTGLRGDRTKLLKKLEEEQEKSKNLEKQKQELENQALNFHDVIETQEKEKEDLKT 92
+++ ++ K++E + + +LEK + N + I+T E EK L
Sbjct: 96 NAKEKLRKNDKSLSEKASKIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAA 155

Query: 93 TLAKTTKENEISEASRKGLSSDLEASRAAKKELEAKHQKLEAENKKLTEANQVSEASRKG 152
A K E + S+ ++ A K LEA+ +LE + + A K
Sbjct: 156 RKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKT 215

Query: 153 LSNDLEASRAAKKELEAKHQKLEADYQVSETSRKGLSRDLEASREANKKVTSELTQAKAQ 212
L + A A K +LE + K L + A ++ L A
Sbjct: 216 LEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNF 275

Query: 213 LSALEESKKLSEKEKAELQAKL----------DAQGKALKEQLAKQTEELAKLRAEKA 260
+A K E EKA L+A+ +A ++L+ L E +L AE
Sbjct: 276 STADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQ 333


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1809GPOSANCHOR1002e-25 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 100 bits (250), Expect = 2e-25
Identities = 148/308 (48%), Positives = 193/308 (62%), Gaps = 28/308 (9%)

Query: 64 KENEELKVEREKYLSYADDKEKDPQYRALMGENQDLRKREGQYQDKIEELEKERKEKQER 123
N + A+ + + L + KI+ LE E+ +
Sbjct: 237 AMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAE 296

Query: 124 QEQLERQYQIE--ADKHYQEQQKKHQQEQQQLEAEKQKLAKDKQISDASRQGLSRDLEAS 181
+ LE Q Q+ + + ++ ++QLEAE QKL + +IS+ASRQ L RDL+AS
Sbjct: 297 KADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDAS 356

Query: 182 REAKKKVEADLAALTAEHQKLKEDKQISDASRQGLSRDLEASREAKKKVEADLAEANSKL 241
REAKK++EA EHQKL+E +IS+ASRQ L RDL+ASREAKK+VE L EANSKL
Sbjct: 357 REAKKQLEA-------EHQKLEEQNKISEASRQSLRRDLDASREAKKQVEKALEEANSKL 409

Query: 242 QALEKLNKELEEGKKLSEKEKAELQARLEAEAKALKEQLAKQAEELAKLK-----GNQTP 296
ALEKLNKELEE KKL+EKEKAELQA+LEAEAKALKE+LAKQAEELAKL+ +QTP
Sbjct: 410 AALEKLNKELEESKKLTEKEKAELQAKLEAEAKALKEKLAKQAEELAKLRAGKASDSQTP 469

Query: 297 NAKVAPQA--------------NRSRSAMTQQKRTLPSTGETANPFFTAAAATVMVSAGM 342
+AK +A N++++ M + KR LPSTGETANPFFTAAA TVM +AG+
Sbjct: 470 DAKPGNKAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETANPFFTAAALTVMATAGV 529

Query: 343 LALKRKEE 350
A+ +++E
Sbjct: 530 AAVVKRKE 537



Score = 69.7 bits (170), Expect = 4e-15
Identities = 77/320 (24%), Positives = 122/320 (38%), Gaps = 4/320 (1%)

Query: 1 MARKDTNKQYSLRKLKTGTASVAVAVAVLGAGFANQTEVKAAEIKKPQADSAWNWPKEYN 60
M + +TN+ YSLRKLKTGTASVAVA+ VLGAG T +A + Q D+ + +
Sbjct: 1 MTKNNTNRHYSLRKLKTGTASVAVALTVLGAGLVVNTNEVSAVATRSQTDTLEKVQERAD 60

Query: 61 ALLKENEELKVEREKYLSYADDKEKDPQYRALMGENQDLRKREGQYQDKIEELEKERKEK 120
EN LK++ + L E + +++ + + E + +E
Sbjct: 61 KFEIENNTLKLKNSDLSFNNKALKD--HNDELTEELSNAKEKLRKNDKSLSEKASKIQEL 118

Query: 121 QERQEQLERQYQI--EADKHYQEQQKKHQQEQQQLEAEKQKLAKDKQISDASRQGLSRDL 178
+ R+ LE+ + + K + E+ L A K L K + + S +
Sbjct: 119 EARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKI 178

Query: 179 EASREAKKKVEADLAALTAEHQKLKEDKQISDASRQGLSRDLEASREAKKKVEADLAEAN 238
+ K +EA A L + A + L + A K +E L A
Sbjct: 179 KTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAM 238

Query: 239 SKLQALEKLNKELEEGKKLSEKEKAELQARLEAEAKALKEQLAKQAEELAKLKGNQTPNA 298
+ A K LE K E +AEL+ LE AK A+ + A
Sbjct: 239 NFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKA 298

Query: 299 KVAPQANRSRSAMTQQKRTL 318
+ Q+ + +R L
Sbjct: 299 DLEHQSQVLNANRQSLRRDL 318



Score = 31.6 bits (71), Expect = 0.005
Identities = 52/234 (22%), Positives = 90/234 (38%), Gaps = 21/234 (8%)

Query: 57 KEYNALLKENEELKVEREKYLSYADDKEKDPQY-----RALMGENQDLRKREGQYQDKIE 111
A + + L+ E+ + D EK + A + + L + + +
Sbjct: 134 NFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQA 193

Query: 112 ELEKERKEKQERQEQLERQYQIEADKH----------------YQEQQKKHQQEQQQLEA 155
ELEK + + + + + + LEA
Sbjct: 194 ELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEA 253

Query: 156 EKQKLAKDKQISDASRQGLSRDLEASREAKKKVEADLAALTAEHQKLKEDKQISDASRQG 215
EK L + + + +G A K +EA+ AAL AE L+ Q+ +A+RQ
Sbjct: 254 EKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQS 313

Query: 216 LSRDLEASREAKKKVEADLAEANSKLQALEKLNKELEEGKKLSEKEKAELQARL 269
L RDL+ASREAKK++EA+ + + + E + L S + K +L+A
Sbjct: 314 LRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQLEAEH 367


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1810GPOSANCHOR1292e-35 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 129 bits (326), Expect = 2e-35
Identities = 117/346 (33%), Positives = 176/346 (50%), Gaps = 16/346 (4%)

Query: 57 KEANKVFEERKALEKQARDLGDTINHMSQTISEQSRKIAALKSEAELKNQQALEALNNKN 116
E K E T+ ++ + + A + +
Sbjct: 193 AELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLE 252

Query: 117 KQISDLTNENAQLKEAIEGYVQ-------TIQNASREIAAKQQELAAAKSQLEAKNAEIE 169
+ + L A+L++A+EG + I+ E AA + E A + Q + NA +
Sbjct: 253 AEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQ 312

Query: 170 ALKQQDASKTEEIAKLQSEAATLENLLGSAKRELTELQAKLDTATAEKAKLESQVTTLEN 229
+L++ + E +L++E LE ++ L+ LD + K +LE++ LE
Sbjct: 313 SLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQLEAEHQKLEE 372

Query: 230 LLGSAKRELTDLQAKLDAANAEKEKLQSQAATLEKQLEATKKELADLQAKLAATNQEKE- 288
++ L+ LDA+ K++++ +L A +K +L+ T +EK
Sbjct: 373 QNKISEASRQSLRRDLDASREAKKQVEKALEEANSKLAALEKLNKELEESKKLTEKEKAE 432

Query: 289 ---KLEAEAKALKEQLAKQAEELAKLKADKASGAQKPDTKPGNKEVPTR----PSQTRTN 341
KLEAEAKALKE+LAKQAEELAKL+A KAS +Q PD KPGNK VP + + T+ N
Sbjct: 433 LQAKLEAEAKALKEKLAKQAEELAKLRAGKASDSQTPDAKPGNKAVPGKGQAPQAGTKPN 492

Query: 342 TNKAPMAQTKRQLPSTGEETTNPFFTAAALTVIASAGVLALKRKEE 387
NKAPM +TKRQLPSTG ET NPFFTAAALTV+A+AGV A+ +++E
Sbjct: 493 QNKAPMKETKRQLPSTG-ETANPFFTAAALTVMATAGVAAVVKRKE 537



Score = 86.7 bits (214), Expect = 1e-20
Identities = 93/334 (27%), Positives = 149/334 (44%), Gaps = 19/334 (5%)

Query: 1 MSKRNPNKLYSLRKLKTGTASVAVALTVLGTGLANTTDVKAESRRYQAPPRVLLQGKEAN 60
M+K N N+ YSLRKLKTGTASVAVALTVLG GL T+ + + + A+
Sbjct: 1 MTKNNTNRHYSLRKLKTGTASVAVALTVLGAGLVVNTNEVSAVATRSQTDTLEKVQERAD 60

Query: 61 KVFEERKALEKQARDLGDTINHMSQTISEQSRKIAALKSEAELKNQQALEALNNKNKQIS 120
K E L+ + DL + E + +++ K + KN ++L +K +++
Sbjct: 61 KFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLR-KNDKSLSEKASKIQELE 119

Query: 121 DLTNENAQLKEAIEGYVQTIQNASREIAAKQQELAAAKSQLEAKNAEIEALKQQDASKTE 180
+ + E + + + A++ LAA K+ LE D++K +
Sbjct: 120 ARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIK 179

Query: 181 EI----AKLQSEAATLENLLGSAKRELTELQAKLDTATAEKAKLESQVTTLENLLGSAKR 236
+ A L++ A LE L A T AK+ T AEKA L ++ LE L A
Sbjct: 180 TLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMN 239

Query: 237 ELTDLQAKLDAANAEKEKLQSQAATLEK--------------QLEATKKELADLQAKLAA 282
T AK+ AEK L+++ A LEK +++ + E A L+A+ A
Sbjct: 240 FSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKAD 299

Query: 283 TNQEKEKLEAEAKALKEQLAKQAEELAKLKADKA 316
+ + L A ++L+ L E +L+A+
Sbjct: 300 LEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQ 333



Score = 29.6 bits (66), Expect = 0.022
Identities = 34/203 (16%), Positives = 74/203 (36%)

Query: 123 TNENAQLKEAIEGYVQTIQNASREIAAKQQELAAAKSQLEAKNAEIEALKQQDASKTEEI 182
T+ +++E + + + + A K + E+ K++ + +
Sbjct: 49 TDTLEKVQERADKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLRKNDKSL 108

Query: 183 AKLQSEAATLENLLGSAKRELTELQAKLDTATAEKAKLESQVTTLENLLGSAKRELTDLQ 242
++ S+ LE ++ L +A+ LE++ L ++ L
Sbjct: 109 SEKASKIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAM 168

Query: 243 AKLDAANAEKEKLQSQAATLEKQLEATKKELADLQAKLAATNQEKEKLEAEAKALKEQLA 302
A +A+ + L+++ A LE + +K L A + + + LEAE AL + A
Sbjct: 169 NFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKA 228

Query: 303 KQAEELAKLKADKASGAQKPDTK 325
+ L + + K T
Sbjct: 229 DLEKALEGAMNFSTADSAKIKTL 251


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1811PF050435360.0 Transcriptional activator
		>PF05043#Transcriptional activator

Length = 493

Score = 536 bits (1383), Expect = 0.0
Identities = 107/491 (21%), Positives = 217/491 (44%), Gaps = 16/491 (3%)

Query: 16 RELKLISYLTENSNVIGVKDKELSKALNISMLTLQSCLTNMQFMKEVGGITYKDGYINIW 75
R+L+L+ L E+ EL++ LN + ++ L++++ I I
Sbjct: 11 RQLELLELLFEHKRWFHRS--ELAELLNCTERAVKDDLSHVKSAFPDLIFHSSTNGIRII 68

Query: 76 YHQCCGLQEVYQKALRESPSLKLLELLFFRDFSSLEELAEELFVSLSTLKRLIKKTNTYL 135
++ VY + S +LE +FF + E + +E ++S S+L R+I + N +
Sbjct: 69 NTDDSDIEMVYHHFFKHSTHFSILEFIFFNEGCQAESICKEFYISSSSLYRIISQINKVI 128

Query: 136 SHTFAISIVTSPVQVSGDERQIRLFYLKYFSEAYKISEWPFGDILNLKNCERLLSLLIKE 195
F + +PVQ+ G+ER IR F+ +YFSE Y EWPF + + + +LL L+ KE
Sbjct: 129 KRQFQFEVSLTPVQIIGNERDIRYFFAQYFSEKYYFLEWPFEN-FSSEPLSQLLELVYKE 187

Query: 196 VDVKVHFTLFQHLKILSGVNLIRYYKGYSCSYNNKKTSHRFSQLIQHSSEIQDLSRLFYL 255
++ + + LK+L NL R G+ + + + + + I+ +++ F
Sbjct: 188 TSFPMNLSTHRMLKLLLVTNLYRIKFGHFMEVDKDSFNDQSLDFLMQAEGIEGVAQSFES 247

Query: 256 KFGLHLDEYTIAEMLSNHLNDKLEIGCAFEIINQDPTSGGRQVTNWIHLL----DEMEIK 311
++ + LDE + ++ ++ I E + V HLL D++ +K
Sbjct: 248 EYNISLDEEVVCQLFVSYFQKMFFID---ESLFMKCVKKDSYVEKSYHLLSDFIDQISVK 304

Query: 312 LNLSITNKYEVAVTLHNASVLNEEDITANYLLFDYKKSYLNFYQKEHPRIYEAFVTSVEK 371
+ I NK + LHN + L +++ ++LFD K + + +Q P+ +
Sbjct: 305 YQIEIENKDNLIWHLHNTAHLYRQELFTEFILFDQKGNTIRNFQNIFPKFVSDVKKELSH 364

Query: 372 LMQADNAQVSKELINQLTYCFFITWENSFLKVNQKDEKVRLLVI----ERSYNSVGNFLK 427
++ S ++N L+Y F ++ + + Q K+++LV+ + V L
Sbjct: 365 YLETLEVCSSSMMVNHLSYTFITHTKHLVINLLQNQPKLKVLVMSNFDQYHAKFVAETLS 424

Query: 428 KYIGEFFSITNFDELDCLTIDLVEIEKQYDVIVTDVMVGKSEELEIFFFYKMIPEAIIDR 487
Y F + + EL+ L + YD+I+++ ++ E + + + ++I
Sbjct: 425 YYCSNNFELEVWTELELSKESLE--DSPYDIIISNFIIPPIENKRLIYSNNINTVSLIYL 482

Query: 488 LNEFLNVSFTD 498
LN + + +
Sbjct: 483 LNAMMFIRLDE 493


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1814PF03544354e-04 Gram-negative bacterial tonB protein
		>PF03544#Gram-negative bacterial tonB protein

Length = 243

Score = 35.3 bits (81), Expect = 4e-04
Identities = 15/74 (20%), Positives = 18/74 (24%), Gaps = 2/74 (2%)

Query: 119 PSPKDQSSQKESQNKDGRPTPSPDQQKDQTPDKTPEKSADKAPEKGPEKAVEKTPEPNRD 178
P+P Q P Q P PE + PE E V +
Sbjct: 44 PAP-AQPISVTMVAPADLEPP-QAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKP 101

Query: 179 TPKPIQPPLAAAAP 192
PKP
Sbjct: 102 KPKPKPVKKVEQPK 115



Score = 32.6 bits (74), Expect = 0.003
Identities = 14/87 (16%), Positives = 23/87 (26%), Gaps = 4/87 (4%)

Query: 111 PNSSDQSTPSPKDQSSQKESQNKDGRPTPSPDQQKDQTPDKTPEKSADKAPEKGPE---- 166
P T ++ P P+ + + P+ E K
Sbjct: 46 PAQPISVTMVAPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKPKP 105

Query: 167 KAVEKTPEPNRDTPKPIQPPLAAAAPV 193
K V+K +P RD P +
Sbjct: 106 KPVKKVEQPKRDVKPVESRPASPFENT 132



Score = 32.3 bits (73), Expect = 0.004
Identities = 19/84 (22%), Positives = 29/84 (34%), Gaps = 6/84 (7%)

Query: 139 PSPDQQKD---QTPDKTPEK---SADKAPEKGPEKAVEKTPEPNRDTPKPIQPPLAAAAP 192
P+P Q P P PE E PEP ++ P I+ P P
Sbjct: 44 PAPAQPISVTMVAPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKP 103

Query: 193 VFAPWRESDKDLSKLKPSSRSSAA 216
P ++ ++ +KP A+
Sbjct: 104 KPKPVKKVEQPKRDVKPVESRPAS 127



Score = 30.3 bits (68), Expect = 0.017
Identities = 13/87 (14%), Positives = 25/87 (28%), Gaps = 4/87 (4%)

Query: 108 TKQPNSSDQSTPSPKDQSSQKE-SQNKDGRPTPSPDQQKDQTPDKTPEKSADKAPEKGPE 166
+ + P + + + +P P P + + P+ PE +
Sbjct: 38 HQVIELPAPAQPISVTMVAPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKP 97

Query: 167 KAVEKTPEPNRDTPKPIQPPLAAAAPV 193
K K K ++ P PV
Sbjct: 98 KPKPKPKPK---PVKKVEQPKRDVKPV 121


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1815MECHCHANNEL320.002 Bacterial mechano-sensitive ion channel signature.
		>MECHCHANNEL#Bacterial mechano-sensitive ion channel signature.

Length = 136

Score = 32.1 bits (73), Expect = 0.002
Identities = 14/62 (22%), Positives = 28/62 (45%), Gaps = 8/62 (12%)

Query: 10 VINGLIIVVVTSILLVLYFAMPIYYTKVKDKEVKREFDQTSKQIKGKTVTEIRDILTKKI 69
V + LI+ ++ A+ + + KE +K+ +TEIRD+L ++
Sbjct: 82 VFDFLIVA------FAIFMAIKLINKLNRKKEEPAAAPAPTKEEV--LLTEIRDLLKEQN 133

Query: 70 NK 71
N+
Sbjct: 134 NR 135


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1816HTHFIS831e-20 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 83.0 bits (205), Expect = 1e-20
Identities = 31/128 (24%), Positives = 55/128 (42%), Gaps = 1/128 (0%)

Query: 3 KILVVEDDDTISQVICEFLKANNYDPDCVFDGQAALDKWQTTSYDLIILDIMLPSLSGLE 62
ILV +DD I V+ + L YD + DL++ D+++P + +
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64

Query: 63 VLKTIRKT-SDVPIIMLTALDDEYTQLVSFNHLISDYVTKPFSPLILIKRIENVLRVSTP 121
+L I+K D+P+++++A + T + + DY+ KPF LI I L
Sbjct: 65 LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKR 124

Query: 122 DEKRQIGD 129
+ D
Sbjct: 125 RPSKLEDD 132


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1819RTXTOXIND544e-10 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 54.4 bits (131), Expect = 4e-10
Identities = 34/144 (23%), Positives = 55/144 (38%), Gaps = 10/144 (6%)

Query: 60 DISLTLAGEVTANNSSKVKIDSSKGEVKDVFVKKGDVVKVGQPLFSYETSQRLTAQSSEF 119
+I T G++T + SK VK++ VK+G+ V+ G L +LTA +E
Sbjct: 81 EIVATANGKLTHSGRSKEIKPIENSIVKEIIVKEGESVRKGDVLL------KLTALGAEA 134

Query: 120 DVQTKANQLQVAKTNAALKWETYNRKVNEINTLKSRYNTAPDESLLEQIRSAEDSVSQAL 179
D + Q + A L+ Y I K PDE + + E +L
Sbjct: 135 DTL----KTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSL 190

Query: 180 SDAKTADSDVKTAQIELDKANATA 203
+ + + Q EL+ A
Sbjct: 191 IKEQFSTWQNQKYQKELNLDKKRA 214



Score = 39.4 bits (92), Expect = 2e-05
Identities = 28/180 (15%), Positives = 61/180 (33%), Gaps = 16/180 (8%)

Query: 120 DVQTKANQLQVAKTNAALKWETYNRKVNEINTLKSRYNTAPDESL---LEQIRSAEDSVS 176
D + ++ +AK + Y VNE+ KS+ E L E + +
Sbjct: 239 DFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKN 298

Query: 177 QALSDAKTADSDVKTAQIELDKANATATTEKGKLEYDTVKSDTAGTIVSLNTDLPNQSKS 236
+ L + ++ +EL K + + +++ + + L
Sbjct: 299 EILDKLRQTTDNIGLLTLELAKNEE-------RQQASVIRAPVSVKVQQLKVHTEGGVV- 350

Query: 237 KKENETFMEII-DKSKMLVKGNISEFDRDKLKIGQKVEV-IDRKDNSK--KWTGKVTQVG 292
ET M I+ + + V + D + +GQ + ++ ++ GKV +
Sbjct: 351 -TTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNIN 409


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1822IGASERPTASE465e-07 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 45.8 bits (108), Expect = 5e-07
Identities = 62/330 (18%), Positives = 108/330 (32%), Gaps = 49/330 (14%)

Query: 290 KVVLSEEAPNLRTAKEKVKTLKGI--LHDYYVE-------TNDLEKAKEYHVEDETSPSQ 340
V L +L K K++ + G L++ VE T ++ + + PS
Sbjct: 954 NVSLVGNTVDLGAWKYKLRNVNGRYDLYNPEVEKRNQTVDTTNITTPNNIQADVPSVPSN 1013

Query: 341 PEAPAKP-EAPSPSPAPGQKPAEDERSSQATEPANPSKEDSSTDASQGSHDSENPATDSP 399
E A+ EAP P PAP E ++ ++ + + E + DA++ + +
Sbjct: 1014 NEEIARVDEAPVPPPAPATPSETTETVAENSKQESKTVEKNEQDATETTAQNR------- 1066

Query: 400 SQPQAPDQGNHQSQVPNDKPQTDKTDTPNVPAPPQDTPKVPEAGGQSGPAGNAEEKAPDS 459
+ K NV A Q T +V ++G ++ E K +
Sbjct: 1067 --------------------EVAKEAKSNVKANTQ-TNEVAQSGSETKETQTTETKETAT 1105

Query: 460 GPKESDQ----SSSKESPSVGEDTTPNQPDVLVGGQSEPIDITEDTITDAPPTVSGHNAS 515
KE ++E P V +P Q QSE + + + PTV+
Sbjct: 1106 VEKEEKAKVETEKTQEVPKVTSQVSPKQE------QSETVQPQAEPARENDPTVNIKEPQ 1159

Query: 516 TQPQSVVEDTAPQRPDVLVGGQSEPIDITQDTQPGMSGSNDATVINEDTKPKRVFHFDNK 575
+Q + + P + Q T +T + N T+P NK
Sbjct: 1160 SQTNTTADTEQPAKETSSNVEQPVTESTTVNTGNSVV-ENPENTTPATTQPTVNSESSNK 1218

Query: 576 ESQASEKAAEQKLAPHDSHTTPQASDDTAA 605
++ + TT T A
Sbjct: 1219 PKNRHRRSVRSVPHNVEPATTSSNDRSTVA 1248


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1823ICENUCLEATIN350.002 Ice nucleation protein signature.
		>ICENUCLEATIN#Ice nucleation protein signature.

Length = 1258

Score = 34.7 bits (79), Expect = 0.002
Identities = 33/117 (28%), Positives = 48/117 (41%), Gaps = 5/117 (4%)

Query: 33 STSASSTKTSASTNINTNTSTASAGTG---TSGTASTTPSVGTSTGGAAGGEAAVASSGG 89
T T ST T+ S AG G T+G +ST + STG A VA G
Sbjct: 155 PTQTIEIATYGSTLSGTHQSQLIAGYGSTETAGDSSTLIAGYGSTGTAGADSTLVAGYGS 214

Query: 90 SQSS--ESAQASTQPQAQTAVAASASTTASPSSSEEKTPKTVTSSTSSTPAASSSSN 144
+Q++ ES+Q + QT + S T S+ ++ + ST A S+
Sbjct: 215 TQTAGEESSQMAGYGSTQTGMKGSDLTAGYGSTGTAGDDSSLIAGYGSTQTAGEDSS 271



Score = 34.3 bits (78), Expect = 0.003
Identities = 37/148 (25%), Positives = 57/148 (38%), Gaps = 8/148 (5%)

Query: 12 SVGLVSVGTMLIAPTVLGQEVSTSASSTKTSASTNINTNTSTASAGTGTSGTASTTPSVG 71
S G + LIA Q ++ T ST S +AG G++GTA S+
Sbjct: 294 STGTAGADSSLIAGYGSTQTAGEESTQTAGYGSTQTAQKGSDLTAGYGSTGTAGDDSSLI 353

Query: 72 T---STGGAAGGEAAVASSGGSQSSESAQASTQPQAQTAVAASASTT-----ASPSSSEE 123
ST A + A G +Q+++ T T A + S+ ++ ++ EE
Sbjct: 354 AGYGSTQTAGEDSSLTAGYGSTQTAQKGSDLTAGYGSTGTAGADSSLIAGYGSTQTAGEE 413

Query: 124 KTPKTVTSSTSSTPAASSSSNGNQVTGT 151
T ST + S + G TGT
Sbjct: 414 STQTAGYGSTQTAQKGSDLTAGYGSTGT 441



Score = 32.8 bits (74), Expect = 0.009
Identities = 34/138 (24%), Positives = 58/138 (42%), Gaps = 5/138 (3%)

Query: 12 SVGLVSVGTMLIAPTVLGQEVSTSASSTKTSASTNINTNTSTASAGTGTSGTASTTPSV- 70
S G + LIA Q ++ T ST S +AG G++GTA S+
Sbjct: 390 STGTAGADSSLIAGYGSTQTAGEESTQTAGYGSTQTAQKGSDLTAGYGSTGTAGDDSSLI 449

Query: 71 -GTSTGGAAGGEAAV-ASSGGSQSSESAQASTQPQAQTAVAASASTTASPSSSEEKT--P 126
G + AG ++++ A G +Q+++ T T+ A S+ + S +
Sbjct: 450 AGYGSTQTAGEDSSLTAGYGSTQTAQKGSDLTAGYGSTSTAGYESSLIAGYGSTQTAGYG 509

Query: 127 KTVTSSTSSTPAASSSSN 144
T+T+ ST A + S+
Sbjct: 510 STLTAGYGSTQTAQNESD 527



Score = 32.8 bits (74), Expect = 0.009
Identities = 32/138 (23%), Positives = 55/138 (39%), Gaps = 5/138 (3%)

Query: 12 SVGLVSVGTMLIAPTVLGQEVSTSASSTKTSASTNINTNTSTASAGTGTSGTASTTPSV- 70
S + LIA Q S ++ T ST S +AG G++GTA + S+
Sbjct: 534 STSTAGANSSLIAGYGSTQTASYNSVLTAGYGSTQTAREGSDLTAGYGSTGTAGSDSSII 593

Query: 71 -GTSTGGAAGGEAAV-ASSGGSQSSESAQASTQPQAQTAVAASASTTASPSSSEEKT--P 126
G + A +++ A G +Q++ T T+ A + S+ + S +
Sbjct: 594 AGYGSTQTASYHSSLTAGYGSTQTAREQSVLTTGYGSTSTAGADSSLIAGYGSTQTAGYN 653

Query: 127 KTVTSSTSSTPAASSSSN 144
+T+ ST A S+
Sbjct: 654 SILTAGYGSTQTAQEGSD 671



Score = 32.4 bits (73), Expect = 0.011
Identities = 37/148 (25%), Positives = 56/148 (37%), Gaps = 8/148 (5%)

Query: 12 SVGLVSVGTMLIAPTVLGQEVSTSASSTKTSASTNINTNTSTASAGTGTSGTASTTPSVG 71
S G + LIA Q +S T ST S +AG G++ TA S+
Sbjct: 438 STGTAGDDSSLIAGYGSTQTAGEDSSLTAGYGSTQTAQKGSDLTAGYGSTSTAGYESSLI 497

Query: 72 T---STGGAAGGEAAVASSGGSQSSESAQASTQPQAQTAVAASASTTASPSSSEEKTP-- 126
ST A G A G +Q++++ T+ A + S+ + S +
Sbjct: 498 AGYGSTQTAGYGSTLTAGYGSTQTAQNESDLITGYGSTSTAGANSSLIAGYGSTQTASYN 557

Query: 127 KTVTSSTSSTPAASSSSN---GNQVTGT 151
+T+ ST A S+ G TGT
Sbjct: 558 SVLTAGYGSTQTAREGSDLTAGYGSTGT 585



Score = 31.6 bits (71), Expect = 0.017
Identities = 37/148 (25%), Positives = 58/148 (39%), Gaps = 8/148 (5%)

Query: 12 SVGLVSVGTMLIAPTVLGQEVSTSASSTKTSASTNINTNTSTASAGTGTSGTASTTPSV- 70
S G + LIA Q +S T ST S +AG G++GTA S+
Sbjct: 246 STGTAGDDSSLIAGYGSTQTAGEDSSLTAGYGSTQTAQKGSDLTAGYGSTGTAGADSSLI 305

Query: 71 -GTSTGGAAGGEAA-VASSGGSQSSESAQASTQPQAQTAVAASASTT-----ASPSSSEE 123
G + AG E+ A G +Q+++ T T A S+ ++ ++ E+
Sbjct: 306 AGYGSTQTAGEESTQTAGYGSTQTAQKGSDLTAGYGSTGTAGDDSSLIAGYGSTQTAGED 365

Query: 124 KTPKTVTSSTSSTPAASSSSNGNQVTGT 151
+ ST + S + G TGT
Sbjct: 366 SSLTAGYGSTQTAQKGSDLTAGYGSTGT 393



Score = 31.6 bits (71), Expect = 0.020
Identities = 36/148 (24%), Positives = 56/148 (37%), Gaps = 8/148 (5%)

Query: 12 SVGLVSVGTMLIAPTVLGQEVSTSASSTKTSASTNINTNTSTASAGTGTSGTASTTPSVG 71
S G + L+A Q +S ST S +AG G++GTA S+
Sbjct: 198 STGTAGADSTLVAGYGSTQTAGEESSQMAGYGSTQTGMKGSDLTAGYGSTGTAGDDSSLI 257

Query: 72 T---STGGAAGGEAAVASSGGSQSSESAQASTQPQAQTAVAASASTT-----ASPSSSEE 123
ST A + A G +Q+++ T T A + S+ ++ ++ EE
Sbjct: 258 AGYGSTQTAGEDSSLTAGYGSTQTAQKGSDLTAGYGSTGTAGADSSLIAGYGSTQTAGEE 317

Query: 124 KTPKTVTSSTSSTPAASSSSNGNQVTGT 151
T ST + S + G TGT
Sbjct: 318 STQTAGYGSTQTAQKGSDLTAGYGSTGT 345



Score = 31.6 bits (71), Expect = 0.021
Identities = 36/148 (24%), Positives = 57/148 (38%), Gaps = 8/148 (5%)

Query: 12 SVGLVSVGTMLIAPTVLGQEVSTSASSTKTSASTNINTNTSTASAGTGTSGTASTTPSV- 70
S G + LIA Q +S T ST S +AG G++GTA S+
Sbjct: 342 STGTAGDDSSLIAGYGSTQTAGEDSSLTAGYGSTQTAQKGSDLTAGYGSTGTAGADSSLI 401

Query: 71 -GTSTGGAAGGEAA-VASSGGSQSSESAQASTQPQAQTAVAASASTT-----ASPSSSEE 123
G + AG E+ A G +Q+++ T T A S+ ++ ++ E+
Sbjct: 402 AGYGSTQTAGEESTQTAGYGSTQTAQKGSDLTAGYGSTGTAGDDSSLIAGYGSTQTAGED 461

Query: 124 KTPKTVTSSTSSTPAASSSSNGNQVTGT 151
+ ST + S + G T T
Sbjct: 462 SSLTAGYGSTQTAQKGSDLTAGYGSTST 489



Score = 31.3 bits (70), Expect = 0.023
Identities = 35/144 (24%), Positives = 54/144 (37%), Gaps = 7/144 (4%)

Query: 12 SVGLVSVGTMLIAPTVLGQEVSTSASSTKTSASTNINTNTSTASAGTGTSGTASTTPSV- 70
S G + +IA Q S +S T ST S + G G++ TA S+
Sbjct: 582 STGTAGSDSSIIAGYGSTQTASYHSSLTAGYGSTQTAREQSVLTTGYGSTSTAGADSSLI 641

Query: 71 -GTSTGGAAGGEAAVASSGGSQSSESAQASTQPQAQTAVAASASTTASPSSSEEKTPKTV 129
G + AG + + + G S Q + + TA S ST + SS T
Sbjct: 642 AGYGSTQTAGYNSILTAGYG-----STQTAQEGSDLTAGYGSTSTAGADSSLIAGYGSTQ 696

Query: 130 TSSTSSTPAASSSSNGNQVTGTEV 153
T+ +S A S G+++
Sbjct: 697 TAGYNSILTAGYGSTQTAQEGSDL 720



Score = 30.5 bits (68), Expect = 0.041
Identities = 32/138 (23%), Positives = 48/138 (34%), Gaps = 5/138 (3%)

Query: 12 SVGLVSVGTMLIAPTVLGQEVSTSASSTKTSASTNINTNTSTASAGTGTSGTASTTPSVG 71
S + LIA Q ++ T ST N S G G++ TA S+
Sbjct: 486 STSTAGYESSLIAGYGSTQTAGYGSTLTAGYGSTQTAQNESDLITGYGSTSTAGANSSLI 545

Query: 72 T---STGGAAGGEAAVASSGGSQSSESAQASTQPQAQTAVAASASTTASPSSSEEKT--P 126
ST A+ A G +Q++ T T A S S+ + S +
Sbjct: 546 AGYGSTQTASYNSVLTAGYGSTQTAREGSDLTAGYGSTGTAGSDSSIIAGYGSTQTASYH 605

Query: 127 KTVTSSTSSTPAASSSSN 144
++T+ ST A S
Sbjct: 606 SSLTAGYGSTQTAREQSV 623



Score = 30.5 bits (68), Expect = 0.043
Identities = 28/105 (26%), Positives = 42/105 (40%), Gaps = 5/105 (4%)

Query: 44 STNINTNTSTASAGTGTSGTASTTPSVGT---STGGAAGGEAAVASSGGSQ--SSESAQA 98
ST S +AG G++ TA + + ST A + +A G +Q S S+
Sbjct: 694 STQTAGYNSILTAGYGSTQTAQEGSDLTSGYGSTSTAGADSSLIAGYGSTQTASYHSSLT 753

Query: 99 STQPQAQTAVAASASTTASPSSSEEKTPKTVTSSTSSTPAASSSS 143
+ QTA S TT S+S ++ + ST A S
Sbjct: 754 AGYGSTQTAREQSVLTTGYGSTSTAGADSSLIAGYGSTQTAGYHS 798


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy182460KDINNERMP270.006 60kDa inner membrane protein signature.
		>60KDINNERMP#60kDa inner membrane protein signature.

Length = 548

Score = 27.2 bits (60), Expect = 0.006
Identities = 6/24 (25%), Positives = 9/24 (37%)

Query: 22 YSKKVLADEPTSYQPPAAHSPCDD 45
+ + A + T AA S D
Sbjct: 27 KNPQPQAQQTTQTTTTAAGSAADQ 50


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1827STREPTOPAIN596e-14 Streptopain (C10) cysteine protease family signature.
		>STREPTOPAIN#Streptopain (C10) cysteine protease family signature.

Length = 398

Score = 59.3 bits (143), Expect = 6e-14
Identities = 39/102 (38%), Positives = 56/102 (54%), Gaps = 7/102 (6%)

Query: 2 EMHFVRTEPEARRIAETFCAENTQTKTPMRVQQLSYPSDTDHSGGEL-----YIYALSPA 56
+ +F R E EA+ A TF ++ K R + D + GGEL Y+Y +S
Sbjct: 28 DQNFARNEKEAKDSAITFIQKSAAIKAGARSAE-DIKLDKVNLGGELSGSNMYVYNISTG 86

Query: 57 GFIIVSGDTRAHTILGYSFDNNLDLN-HDNVRSMVEAYQKQI 97
GF+IVSGD R+ ILGYS + D N +N+ S +E+Y +QI
Sbjct: 87 GFVIVSGDKRSPEILGYSTSGSFDANGKENIASFMESYVEQI 128


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1828STREPTOPAIN7110.0 Streptopain (C10) cysteine protease family signature.
		>STREPTOPAIN#Streptopain (C10) cysteine protease family signature.

Length = 398

Score = 711 bits (1835), Expect = 0.0
Identities = 395/398 (99%), Positives = 396/398 (99%)

Query: 1 MNKKKLGIRLLSLLALGGFVLANPVFADQNFARNEKEAKDSAITFIQKSAAIKAGARSTE 60
MNKKKLG+RLLSLLALGGFVLANPVFADQNFARNEKEAKDSAITFIQKSAAIKAGARS E
Sbjct: 1 MNKKKLGVRLLSLLALGGFVLANPVFADQNFARNEKEAKDSAITFIQKSAAIKAGARSAE 60

Query: 61 DIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASF 120
DIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASF
Sbjct: 61 DIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASF 120

Query: 121 MESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGE 180
MESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGE
Sbjct: 121 MESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGE 180

Query: 181 QSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQY 240
QSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQY
Sbjct: 181 QSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQY 240

Query: 241 NWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQ 300
NWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQ
Sbjct: 241 NWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQ 300

Query: 301 SVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWG 360
SVHQINR DFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWG
Sbjct: 301 SVHQINRGDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWG 360

Query: 361 GVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP 398
GVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP
Sbjct: 361 GVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP 398


26MGAS10750_Spy1858MGAS10750_Spy1878Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy18580213.588551CtsR family transcriptional regulator
MGAS10750_Spy18590254.082086Cold shock protein
MGAS10750_Spy1860-1254.342053*Peroxiredoxin
MGAS10750_Spy1861-1265.452937Peroxiredoxin reductase (NAD(P)H) / NADH oxidase
MGAS10750_Spy1862-1255.596236imidazolonepropionase
MGAS10750_Spy18630286.050429urocanate hydratase
MGAS10750_Spy1864-1296.355960glutamate formiminotransferase
MGAS10750_Spy1865-1306.394446formiminotetrahydrofolate cyclodeaminase
MGAS10750_Spy1866-1245.105688formate--tetrahydrofolate ligase
MGAS10750_Spy1867-2234.399652hypothetical protein
MGAS10750_Spy1868-1244.252730amino acid permease
MGAS10750_Spy1869-1193.900295histidine ammonia-lyase
MGAS10750_Spy1870-2173.334862formimidoylglutamase
MGAS10750_Spy1871-2163.000191LuxR family transcriptional regulator
MGAS10750_Spy1872-1163.03375830S ribosomal protein S2
MGAS10750_Spy1873-2142.976373elongation factor Ts
MGAS10750_Spy1874-1142.978549Oligoendopeptidase O
MGAS10750_Spy18750153.135133Trehalose-6-phosphate hydrolase
MGAS10750_Spy18761142.871050PTS system, trehalose-specific IIBC component /
MGAS10750_Spy18770192.818786Trehalose operon transcriptional repressor
MGAS10750_Spy18780183.180229MarR family transcriptional regulator
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1861PF07212300.022 Hyaluronoglucosaminidase
		>PF07212#Hyaluronoglucosaminidase

Length = 336

Score = 30.0 bits (67), Expect = 0.022
Identities = 34/145 (23%), Positives = 58/145 (40%), Gaps = 22/145 (15%)

Query: 242 GGQVMETVGIENMIGTLYT--EGPKLMAEVEAHTKSYDVDIIKAQLATSIEKKENIEVTL 299
G M+ G+E +GTL E P + A + + + +DI+K K++ + T
Sbjct: 205 NGSAMQIRGVEKALGTLKITHENPNVEANYDENAAALSIDIVK--------KQKGGKGTA 256

Query: 300 ANGAVLQAKTAILALGAKWRNINVPGEDEFRNKGVTYCPHCDGPLFEGKDVAVIGGGNSG 359
A G + + + + RN+ +D+F K DG + K + GN
Sbjct: 257 AQGIYINSTSGTTGKLLRIRNLG---DDKFYVKH-------DGGFYAKKTSQI--DGNLK 304

Query: 360 LEAALDLAGLAKHVYVLEFLPELKA 384
L+ A YV + +LKA
Sbjct: 305 LKNPTADDHAATKAYVDSEVKKLKA 329


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1862UREASE447e-07 Urea amidohydrolase (urease) protein signature.
		>UREASE#Urea amidohydrolase (urease) protein signature.

Length = 570

Score = 44.3 bits (105), Expect = 7e-07
Identities = 21/53 (39%), Positives = 31/53 (58%), Gaps = 6/53 (11%)

Query: 46 IAIKDSLIVALG-SGEPDAE-----LVGPQTIMRSYKGKIATPGIIDCHTHLV 92
I +KD I A+G +G PD + +VGP T + + +GKI T G +D H H +
Sbjct: 88 IGLKDGRIAAIGKAGNPDMQPGVTIIVGPGTEVIAGEGKIVTAGGMDSHIHFI 140


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1874IGASERPTASE310.020 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 30.8 bits (69), Expect = 0.020
Identities = 20/118 (16%), Positives = 35/118 (29%), Gaps = 17/118 (14%)

Query: 438 NAYYDPQQNQIVFPAAILQEPFYSLDQSSSANYGGIGAVIAHEISHAFDT---------N 488
+ + A + S+ N+ +G + + N
Sbjct: 594 YLNLENYTYYALRKGASTRSELPKNSGESNENWLYMGKTSDEAKRNVMNHINNERMNGFN 653

Query: 489 GASFDEHGSLNDWWTQEDYAAFKERTDKIVAQFDGLESHGAKVNGKLTVSENVADLGG 546
G +E G N FK ++++ G G +NG LTV + L G
Sbjct: 654 GYFGEEEGKNNGNLN----VTFKGKSEQNRFLLTG----GTNLNGDLTVEKGTLFLSG 703


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1876RTXTOXIND320.007 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 32.1 bits (73), Expect = 0.007
Identities = 6/18 (33%), Positives = 12/18 (66%)

Query: 610 LVKQGDQVKAGQTLIQFD 627
+VK+G+ V+ G L++
Sbjct: 111 IVKEGESVRKGDVLLKLT 128


27MGAS10750_Spy1897MGAS10750_Spy1916Y        NNGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy1897121-4.098385DNA integration/recombination/inversion protein
MGAS10750_Spy1898222-4.113839hypothetical protein
MGAS10750_Spy1899221-4.247081Cro/CI family transcriptional regulator
MGAS10750_Spy1900224-1.946744Cro/CI family transcriptional regulator
MGAS10750_Spy1901022-2.434593phage antirepressor protein
MGAS10750_Spy1902120-2.290122Prophage antirepressor
MGAS10750_Spy1903420-2.465254phage protein
MGAS10750_Spy1904523-0.190734hypothetical protein
MGAS10750_Spy1905622-0.552058phage protein
MGAS10750_Spy1906521-0.677436phage protein
MGAS10750_Spy19076230.085050phage protein
MGAS10750_Spy1908521-0.146484phage protein
MGAS10750_Spy1909421-0.431887phage protein
MGAS10750_Spy1910321-2.772637DNA primase
MGAS10750_Spy1911-118-4.028543phage protein
MGAS10750_Spy1912016-4.576364phage protein
MGAS10750_Spy1913317-5.635999phage protein
MGAS10750_Spy1914118-6.429369phage protein
MGAS10750_Spy1915217-5.542898hypothetical protein
MGAS10750_Spy1916219-4.636666hypothetical protein
28MGAS10750_Spy1932MGAS10750_Spy1943Y        NNGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy1932222-3.92523350S ribosomal protein L32
MGAS10750_Spy1933320-3.73041250S ribosomal protein L33
MGAS10750_Spy1934420-3.649012Cadmium resistance protein
MGAS10750_Spy1935522-4.077253Cadmium efflux system accessory protein
MGAS10750_Spy1936520-3.175282hypothetical protein
MGAS10750_Spy1937623-1.310920FtsK/SpoIIIE family
MGAS10750_Spy1938622-1.843721hypothetical protein
MGAS10750_Spy1939623-2.265444transcriptional regulator
MGAS10750_Spy1940422-0.823147hypothetical protein
MGAS10750_Spy1941420-0.000314membrane protein
MGAS10750_Spy19423170.953914phosphohydrolase
MGAS10750_Spy19432140.352013hypothetical protein
29MGAS10750_Spy0094MGAS10750_Spy0101N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy0094220-3.739206ComG operon protein 2
MGAS10750_Spy0095020-2.752827ComG operon protein 3
MGAS10750_Spy0096-214-1.388663ComG operon protein 4
MGAS10750_Spy0097-115-1.108972ComG operon protein 5
MGAS10750_Spy0098-3160.120731ComG operon protein 6
MGAS10750_Spy0099-2161.906544ComG operon protein 6
MGAS10750_Spy0100-2162.172678Adenine-specific methyltransferase
MGAS10750_Spy0101-1182.701029acetate kinase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0094BCTERIALGSPF903e-22 Bacterial general secretion pathway protein F signa...
		>BCTERIALGSPF#Bacterial general secretion pathway protein F

signature.
Length = 408

Score = 90.3 bits (224), Expect = 3e-22
Identities = 65/341 (19%), Positives = 135/341 (39%), Gaps = 22/341 (6%)

Query: 37 KKLSSKHQHKFIQLLANLLSTGFSFAEVIAFLKRS--QLLQLDYVLKMEESLLKGQGLAD 94
+LS+ + LA L++ E + + + + + + +++G LAD
Sbjct: 63 IRLSTSDLALLTRQLATLVAASMPLEEALDAVAKQSEKPHLSQLMAAVRSKVMEGHSLAD 122

Query: 95 MLSGLG--FSDAILTQISLADRHGNIETTLVAIQHYLNQMARIRRKTVEVITYPLILLLF 152
+ F ++ + G+++ L + Y Q ++R + + + YP +L +
Sbjct: 123 AMKCFPGSFERLYCAMVAAGETSGHLDAVLNRLADYTEQRQQMRSRIQQAMIYPCVLTVV 182

Query: 153 LFVMMLGLRRYLVPQLETQNQ---------------ITYFLNHFPAFFIGFCSGLILLFG 197
++ L +VP++ Q ++ + F + + + F
Sbjct: 183 AIAVVSILLSVVVPKVVEQFIHMKQALPLSTRVLMGMSDAVRTFGPWMLLALLAGFMAFR 242

Query: 198 MVWLRWRSQSRLKLYSRLSRYPFLGKLLKQYLTSYYAREWGTLIGQGLDLMTILDIMAIE 257
+ LR + + R+ + RL P +G++ + T+ YAR L + L+ + I
Sbjct: 243 V-MLR-QEKRRVSFHRRLLHLPLIGRIARGLNTARYARTLSILNASAVPLLQAMRISGDV 300

Query: 258 KSSL-MKELAEDIRMSLLEGQAFHIKVATYPFFKKELSLMIEYGEIKSKLGAELEIYAQE 316
S+ + ++ EG + H + F + MI GE +L + LE A
Sbjct: 301 MSNDYARHRLSLATDAVREGVSLHKALEQTALFPPMMRHMIASGERSGELDSMLERAADN 360

Query: 317 SWEQFFSQLYQVTQLIQPAIFLVVAVTIVMIYAAILLPIYQ 357
+F SQ+ L +P + + +A ++ I AIL PI Q
Sbjct: 361 QDREFSSQMTLALGLFEPLLVVSMAAVVLFIVLAILQPILQ 401



Score = 34.8 bits (80), Expect = 4e-04
Identities = 32/129 (24%), Positives = 60/129 (46%), Gaps = 6/129 (4%)

Query: 235 REWGTLIGQGLDLMTILDIMAIE-KSSLMKELAEDIRMSLLEGQAFHIKVATYP-FFKKE 292
R+ TL+ + L LD +A + + + +L +R ++EG + + +P F++
Sbjct: 75 RQLATLVAASMPLEEALDAVAKQSEKPHLSQLMAAVRSKVMEGHSLADAMKCFPGSFERL 134

Query: 293 LSLMIEYGEIKSKLGAELEIYA--QESWEQFFSQLYQVTQLIQPAIFLVVAVTIVMIYAA 350
M+ GE L A L A E +Q S++ Q +I P + VVA+ +V I +
Sbjct: 135 YCAMVAAGETSGHLDAVLNRLADYTEQRQQMRSRIQQA--MIYPCVLTVVAIAVVSILLS 192

Query: 351 ILLPIYQNM 359
+++P
Sbjct: 193 VVVPKVVEQ 201


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0095BCTERIALGSPG527e-12 Bacterial general secretion pathway protein G signa...
		>BCTERIALGSPG#Bacterial general secretion pathway protein G

signature.
Length = 145

Score = 52.2 bits (125), Expect = 7e-12
Identities = 27/89 (30%), Positives = 49/89 (55%), Gaps = 4/89 (4%)

Query: 14 KGFTLLEMLLVILVISVLMLLFVPNLSKQKDRVTETGNAAVVKLVENQAELYELSQGSKP 73
+GFTLLE+++VI++I VL L VPNL K++ + + + +EN ++Y+L P
Sbjct: 8 RGFTLLEIMVVIVIIGVLASLVVPNLMGNKEKADKQKAVSDIVALENALDMYKLDNHHYP 67

Query: 74 SLSQ-LKA--DGSITEKQEKAY-QDYYDK 98
+ +Q L++ + Y ++ Y K
Sbjct: 68 TTNQGLESLVEAPTLPPLAANYNKEGYIK 96


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0098OMPTIN270.034 Omptin serine protease signature.
		>OMPTIN#Omptin serine protease signature.

Length = 317

Score = 26.9 bits (59), Expect = 0.034
Identities = 17/71 (23%), Positives = 25/71 (35%), Gaps = 9/71 (12%)

Query: 37 LLKRSHYLARHDQDNWLLFSHQL--REELSGARFYKVADNK-LYVEKGKKVLAFGQFKSH 93
K S ++ D D ++ R ++ +Y VA N YV KV G +
Sbjct: 217 TFKYSGWVESSDNDEHYDPGKRITYRSKVKDQNYYSVAVNAGYYVTPNAKVYVEGAWNRV 276

Query: 94 DFRKSASNGKG 104
N KG
Sbjct: 277 T------NKKG 281


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0101ACETATEKNASE498e-179 Acetate kinase family signature.
		>ACETATEKNASE#Acetate kinase family signature.

Length = 400

Score = 498 bits (1285), Expect = e-179
Identities = 208/401 (51%), Positives = 280/401 (69%), Gaps = 7/401 (1%)

Query: 3 KTIAINAGSSSLKWQLYQMPEEAVLAQGIIERIGLKDSISTVKYDGKKEEQILDIHDHTE 62
K + IN GSSSLK+QL + + VLA+G+ ERIG+ DS+ T +G+K + D+ DH +
Sbjct: 2 KILVINCGSSSLKYQLIESKDGNVLAKGLAERIGINDSLLTHNANGEKIKIKKDMKDHKD 61

Query: 63 AVKILLNDLI--HFGIIAAYDEITGVGHRVVAGGELFKESVVVNDKVLEQIEELSVLAPL 120
A+K++L+ L+ +G+I EI VGHRVV GGE F SV++ D VL+ I + LAPL
Sbjct: 62 AIKLVLDALVNSDYGVIKDMSEIDAVGHRVVHGGEYFTSSVLITDDVLKAITDCIELAPL 121

Query: 121 HNPGAAAGIRAFRDILPDITSVCVFDTSFHTSMAKHTYLYPIPQKYYTDYKVRKYGAHGT 180
HNP GI+A I+PD+ V VFDT+FH +M + YLYPIP +YYT YK+RKYG HGT
Sbjct: 122 HNPANIEGIKACTQIMPDVPMVAVFDTAFHQTMPDYAYLYPIPYEYYTKYKIRKYGFHGT 181

Query: 181 SHKYVAQEAAKMLGRPLEELKLITAHIGNGVSITANYHGQSADTSMGFTPLAGPMMGTRS 240
SHKYV+Q AA++L +P+E LK+IT H+GNG SI A +G+S DTSMGFTPL G MGTRS
Sbjct: 182 SHKYVSQRAAEILNKPIESLKIITCHLGNGSSIAAVKNGKSIDTSMGFTPLEGLAMGTRS 241

Query: 241 GDIDPAIIPYLIEQDPELKDAADVVNMLNKKSGLSGVSGISSDMRDI-EAGLQEDNPDAV 299
G IDP+II YL+E+ E A +VVN+LNKKSG+ G+SGISSD RD+ +A + + A
Sbjct: 242 GSIDPSIISYLMEK--ENISAEEVVNILNKKSGVYGISGISSDFRDLEDAAFKNGDKRAQ 299

Query: 300 LAYNIFIDRIKKCIGQYFAVLNGADALVFTAGMGENAPLMRQDVIGGLTWFGMDIDPEKN 359
LA N+F R+KK IG Y A + G D +VFTAG+GEN P +R+ ++ GL + G +D EKN
Sbjct: 300 LALNVFAYRVKKTIGSYAAAMGGVDVIVFTAGIGENGPEIREFILDGLEFLGFKLDKEKN 359

Query: 360 -VFGYRGDISTPESKVKVLVISTDEELCIARDVERL-KNTK 398
V G IST +SKV V+V+ T+EE IA+D E++ ++ K
Sbjct: 360 KVRGEEAIISTADSKVNVMVVPTNEEYMIAKDTEKIVESLK 400


30MGAS10750_Spy0614MGAS10750_Spy0621N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy06144262.885548phage endopeptidase
MGAS10750_Spy06154233.234769Hyaluronoglucosaminidase
MGAS10750_Spy06163221.842186phage infection protein
MGAS10750_Spy0617020-0.552947phage protein
MGAS10750_Spy06180150.812704phage protein
MGAS10750_Spy0619-1140.328806phage protein
MGAS10750_Spy0620-2121.091523phage-associated cell wall hydrolase
MGAS10750_Spy0621-2120.550522Enterotoxin
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0614SSPAMPROTEIN290.036 Salmonella surface presentation of antigen gene typ...
		>SSPAMPROTEIN#Salmonella surface presentation of antigen gene type M

signature.
Length = 147

Score = 28.9 bits (64), Expect = 0.036
Identities = 23/65 (35%), Positives = 29/65 (44%), Gaps = 6/65 (9%)

Query: 387 ERINALENNQKVITNNQKQFELNLPKYLNDINGKRVWYEKPDDNIEHKIGDYWFEKNGKY 446
E I AL Q ++ K EL + + I KR EK + + K YW K G Y
Sbjct: 66 EEIYALLRKQSIVRRQIKDLELQIIQ----IQEKRSELEKKREEFQEK-SKYWLRKEGNY 120

Query: 447 QRTWI 451
QR WI
Sbjct: 121 QR-WI 124


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0615PF072125630.0 Hyaluronoglucosaminidase
		>PF07212#Hyaluronoglucosaminidase

Length = 336

Score = 563 bits (1452), Expect = 0.0
Identities = 336/336 (100%), Positives = 336/336 (100%)

Query: 1 MTETIPLRVQFKRMTAEEWTRSDVILLESEIGFETDTGYAKFGDGKNQFSKLKYLNKPDL 60
MTETIPLRVQFKRMTAEEWTRSDVILLESEIGFETDTGYAKFGDGKNQFSKLKYLNKPDL
Sbjct: 1 MTETIPLRVQFKRMTAEEWTRSDVILLESEIGFETDTGYAKFGDGKNQFSKLKYLNKPDL 60

Query: 61 GAFAQKEETNSKITKLESSKADKNAVYLKAESKIELDKKLNLKGGVMTGQLQFKPNKSGI 120
GAFAQKEETNSKITKLESSKADKNAVYLKAESKIELDKKLNLKGGVMTGQLQFKPNKSGI
Sbjct: 61 GAFAQKEETNSKITKLESSKADKNAVYLKAESKIELDKKLNLKGGVMTGQLQFKPNKSGI 120

Query: 121 KPSSSVGGAINIDMSKSEGAGVVVYSNNDTSDGPLMSLRTGKETFNQSALFVDYSGKTNA 180
KPSSSVGGAINIDMSKSEGAGVVVYSNNDTSDGPLMSLRTGKETFNQSALFVDYSGKTNA
Sbjct: 121 KPSSSVGGAINIDMSKSEGAGVVVYSNNDTSDGPLMSLRTGKETFNQSALFVDYSGKTNA 180

Query: 181 VNIAMRQPTTPNFSSALNITSGNENGSAMQIRGVEKALGTLKITHENPNVEANYDENAAA 240
VNIAMRQPTTPNFSSALNITSGNENGSAMQIRGVEKALGTLKITHENPNVEANYDENAAA
Sbjct: 181 VNIAMRQPTTPNFSSALNITSGNENGSAMQIRGVEKALGTLKITHENPNVEANYDENAAA 240

Query: 241 LSIDIVKKQKGGKGTAAQGIYINSTSGTTGKLLRIRNLGDDKFYVKHDGGFYAKKTSQID 300
LSIDIVKKQKGGKGTAAQGIYINSTSGTTGKLLRIRNLGDDKFYVKHDGGFYAKKTSQID
Sbjct: 241 LSIDIVKKQKGGKGTAAQGIYINSTSGTTGKLLRIRNLGDDKFYVKHDGGFYAKKTSQID 300

Query: 301 GNLKLKNPTADDHAATKAYVDSEVKKLKALLMDKQV 336
GNLKLKNPTADDHAATKAYVDSEVKKLKALLMDKQV
Sbjct: 301 GNLKLKNPTADDHAATKAYVDSEVKKLKALLMDKQV 336


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0616RTXTOXIND340.003 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 33.6 bits (77), Expect = 0.003
Identities = 27/145 (18%), Positives = 51/145 (35%), Gaps = 21/145 (14%)

Query: 158 RLSSSYQSGINGLKAQLANDKI---GLQAEIQATAQGLSQKYDNELRQLSAKITTTSSGT 214
RL+S + + + Q ++ +AE T +Y+N R +++ SS
Sbjct: 186 RLTSLIKEQFSTWQNQKYQKELNLDKKRAERL-TVLARINRYENLSRVEKSRLDDFSSLL 244

Query: 215 TEAYESKLAGLRAEFTRSNQGMRIELESQISGLRAVQQSTASQISQEIRDRTGAVSRVQQ 274
+ +K A L E E++ + SQ+ Q + A Q
Sbjct: 245 HKQAIAKHAVL-------------EQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQL 291

Query: 275 DLESYQR----RLQDAEDNYSSLTH 295
+ ++ +L+ DN LT
Sbjct: 292 VTQLFKNEILDKLRQTTDNIGLLTL 316


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0620FLGFLGJ977e-25 Flagellar protein FlgJ signature.
		>FLGFLGJ#Flagellar protein FlgJ signature.

Length = 313

Score = 97.1 bits (241), Expect = 7e-25
Identities = 46/123 (37%), Positives = 65/123 (52%), Gaps = 8/123 (6%)

Query: 23 SLTAAQAILESGWGKHA-------PHNALFGIKADASWTGKSFNTKTQEEYQAGVITDIV 75
L AQA LESGWG+ P LFG+KA +W G T E Y+ G +
Sbjct: 172 HLILAQAALESGWGQRQIRRENGEPSYNLFGVKASGNWKGPVTEITTTE-YENGEAKKVK 230

Query: 76 DRFRAYDSWDESIADHGQFLVDNPRYQSVIGEADYKKACHAIKDAGYATASGYAELLIQI 135
+FR Y S+ E+++D+ L NPRY +V A ++ A++DAGYAT YA L +
Sbjct: 231 AKFRVYSSYLEALSDYVGLLTRNPRYAAVTTAASAEQGAQALQDAGYATDPHYARKLTNM 290

Query: 136 IEE 138
I++
Sbjct: 291 IQQ 293


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0621BACTRLTOXIN1736e-56 Bacterial toxin signature.
		>BACTRLTOXIN#Bacterial toxin signature.

Length = 266

Score = 173 bits (440), Expect = 6e-56
Identities = 61/255 (23%), Positives = 117/255 (45%), Gaps = 28/255 (10%)

Query: 5 HIIKIVFIITVILISTISPIIKSDSKKDISNVKSDLLYAYTITPYDYKDCRVNFSTT--- 61
+I I +I VI + + D D + S+ Y Y D V+ +
Sbjct: 9 RVILIFALILVISTPNVLAESQPDPMPDDLHKSSEFTGTMGNMKYLYDDHYVSATKVKSV 68

Query: 62 -----HTL--NIDTQKYRGKDYYISSEMSYEASQKFKRDDHVDVFGLFYILNSHTGEY-- 112
H L NI +K + D + ++ + ++K+K D+ VDV+G Y +N +
Sbjct: 69 DKFLAHDLIYNISDKKLKNYDKVKTELLNEDLAKKYK-DEVVDVYGSNYYVNCYFSSKDN 127

Query: 113 ----------IYGGITPAQNNKVNHKLLGNLFIS-GESQQN-LNNKIILEKDIVTFQEID 160
+YGGIT + N ++ L N+ + E+++N ++ ++ +K VT QE+D
Sbjct: 128 VGKVTGGKTCMYGGITKHEGNHFDNGNLQNVLVRVYENKRNTISFEVQTDKKSVTAQELD 187

Query: 161 FKIRKYLMDNYKIYD-ATSPYVSGRIEIGTKDGKHEQIDLFDSPNEG-TRSDIFAKYKDN 218
K R +L++ +Y+ +SPY +G I+ +G D+ +P + +S Y DN
Sbjct: 188 IKARNFLINKKNLYEFNSSPYETGYIKFIENNGNTFWYDMMPAPGDKFDQSKYLMMYNDN 247

Query: 219 RIINMKNFSHFDIYL 233
+ ++ K+ +++L
Sbjct: 248 KTVDSKS-VKIEVHL 261


31MGAS10750_Spy0876MGAS10750_Spy0881N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy08763181.469112phage protein
MGAS10750_Spy08774161.134577phage structural protein
MGAS10750_Spy0878418-0.584100phage protein
MGAS10750_Spy0879421-0.349651phage protein
MGAS10750_Spy08804210.076436phage protein
MGAS10750_Spy0881620-0.019779N-acetylmuramoyl-L-alanine amidase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0876FLGFLGJ405e-05 Flagellar protein FlgJ signature.
		>FLGFLGJ#Flagellar protein FlgJ signature.

Length = 313

Score = 39.7 bits (92), Expect = 5e-05
Identities = 32/139 (23%), Positives = 56/139 (40%), Gaps = 9/139 (6%)

Query: 294 VFSQLYLESFWGDTPVGRAD----NNWGGI----TWTGATTRPSGINVSQGQPRAEGGHY 345
+ +Q LES WG + R + N G+ W G T + G+ + +
Sbjct: 174 ILAQAALESGWGQRQIRRENGEPSYNLFGVKASGNWKGPVTEITTTEYENGEAKKVKAKF 233

Query: 346 NHYASVDDYLKDYTYLLAEQGIY-AVKGKLTIDEYTRGLFRVGGATYDYAAAGYDHYAPL 404
Y+S + L DY LL Y AV + ++ + L G AT + A +
Sbjct: 234 RVYSSYLEALSDYVGLLTRNPRYAAVTTAASAEQGAQALQDAGYATDPHYARKLTNMIQQ 293

Query: 405 MRDIRAGINRNNNGAMDNV 423
M+ I +++ + +DN+
Sbjct: 294 MKSISDKVSKTYSMNIDNL 312


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0879CARBMTKINASE260.007 Bacterial carbamate kinase signature.
		>CARBMTKINASE#Bacterial carbamate kinase signature.

Length = 314

Score = 25.9 bits (57), Expect = 0.007
Identities = 13/41 (31%), Positives = 18/41 (43%), Gaps = 14/41 (34%)

Query: 25 EFGWITLEDVPKKYR--------------DKVKQLVESGNI 51
E GWI ED + +R + +K+LVE G I
Sbjct: 148 EKGWIVKEDSGRGWRRVVPSPDPKGHVEAETIKKLVERGVI 188


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0880FRAGILYSIN280.006 Fragilysin metallopeptidase (M10C) enterotoxin signat...
		>FRAGILYSIN#Fragilysin metallopeptidase (M10C) enterotoxin

signature.
Length = 405

Score = 28.5 bits (63), Expect = 0.006
Identities = 15/63 (23%), Positives = 25/63 (39%), Gaps = 5/63 (7%)

Query: 40 VSAPVKHVLDNNKKAMEALESAIVKISDD-----LKDNNFKWTESKNHRDRLQKVQDQHE 94
+ APV +D + L + + +SD LKDN F + R + D
Sbjct: 38 IDAPVTASIDLQSVSYTDLATQLNDVSDFGKMIILKDNGFNRQVHVSMDKRTKIQLDNEN 97

Query: 95 IRI 97
+R+
Sbjct: 98 VRL 100


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy0881UREASE280.009 Urea amidohydrolase (urease) protein signature.
		>UREASE#Urea amidohydrolase (urease) protein signature.

Length = 570

Score = 27.8 bits (62), Expect = 0.009
Identities = 11/54 (20%), Positives = 21/54 (38%), Gaps = 5/54 (9%)

Query: 46 VARNAVEAVEQIAYDKDIK---GIEKLTEAKIAVRDELSKHNVYLSDK--QMEV 94
++V V Q + D + G+ K A R + K ++ + +EV
Sbjct: 486 RTNSSVTFVSQASLDAGLAGRLGVAKELVAVQNTRGGIGKASMIHNSLTPHIEV 539


32MGAS10750_Spy1360MGAS10750_Spy1367N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy1360-2152.287614undecaprenyldiphospho-muramoylpentapeptide
MGAS10750_Spy1361-1181.963897UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
MGAS10750_Spy13621242.035988hypothetical protein
MGAS10750_Spy13630211.630491GTP-binding protein TypA/BipA
MGAS10750_Spy13640130.161619Rhodanese-related sulfurtransferases
MGAS10750_Spy1365-114-0.761280glucokinase
MGAS10750_Spy1366317-2.692438hypothetical protein
MGAS10750_Spy1367116-2.180706Non-specific DNA-binding protein Dps /
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1360LIPPROTEIN48300.018 Mycoplasma P48 major surface lipoprotein signature.
		>LIPPROTEIN48#Mycoplasma P48 major surface lipoprotein signature.

Length = 428

Score = 29.6 bits (66), Expect = 0.018
Identities = 19/98 (19%), Positives = 28/98 (28%), Gaps = 8/98 (8%)

Query: 154 FEQEDQLSKVKHLGAVTKVFKDTNQMPESTQLEAVKEYFSRDLKTLLFIGGSAGAHVFNQ 213
FE ++K + N P S A S K + G Q
Sbjct: 83 FEALKAINKQTGIEIN-------NVEPSSNFESAYNSALSAGHKIWVLNGFKHQQS-IKQ 134

Query: 214 FISDHPELKQRYNIINITGDPHLNELSSHLYRVDYVTD 251
+I H E +R I I D + Y + +
Sbjct: 135 YIDAHREELERNQIKIIGIDFDIETEYKWFYSLQFNIK 172


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1363TCRTETOQM1864e-53 Tetracycline resistance protein TetO/TetQ/TetM family ...
		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

signature.
Length = 639

Score = 186 bits (473), Expect = 4e-53
Identities = 102/477 (21%), Positives = 187/477 (39%), Gaps = 97/477 (20%)

Query: 8 IRNVAIIAHVDHGKTTLVDELLKQSHTLDERKELQE--RAMDSNDLEKERGITILAKNTA 65
I N+ ++AHVD GKTTL + LL S + E + + D+ LE++RGITI T+
Sbjct: 3 IINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGITS 62

Query: 66 VAYNDVRINIMDTPGHADFGGEVERIMKMVDGVVLVVDAYEGTMPQTRFVLKKALEQNLI 125
+ + ++NI+DTPGH DF EV R + ++DG +L++ A +G QTR + + +
Sbjct: 63 FQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALRKMGIP 122

Query: 126 PIVVVNKIDKPSARP-------------------------------------AEVVDEVL 148
I +NKID+ + V E
Sbjct: 123 TIFFINKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVELYPNMCVTNFTESEQWDTVIEGN 182

Query: 149 ELFIELGADDEQLE-----------------FPVVYASAINGTSSLSDDPADQEHTMAPI 191
+ +E + LE FPV + SA N + +
Sbjct: 183 DDLLEKYMSGKSLEALELEQEESIRFHNCSLFPVYHGSAKNNIG------------IDNL 230

Query: 192 FDTIIDHIPAPVDNSDEPLQFQVSLLDYNDFVGRIGIGRVFRGTVKVGDQVTLSKLDGTT 251
+ I + + L +V ++Y++ R+ R++ G + + D V +S
Sbjct: 231 IEVITNKFYSSTHRGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLHLRDSVRIS----EK 286

Query: 252 KNFRVTKLFGFFGLERREIQEAKAGDLIAVSGMEDIFVGETITPTDCVEALPILRIDEPT 311
+ ++T+++ E +I +A +G+++ + E + + + T + + P
Sbjct: 287 EKIKITEMYTSINGELCKIDKAYSGEIVILQN-EFLKLNSVLGDTKLLPQRERIENPLPL 345

Query: 312 LQMTFLVNNSPFAGREGKWITSRKVEER--LLAELQT----DVSLRVDPTDSPDKWTVSG 365
LQ T + K ++R LL L D LR + + +S
Sbjct: 346 LQTT---------------VEPSKPQQREMLLDALLEISDSDPLLRYYVDSATHEIILSF 390

Query: 366 RGELHLSILIETMRRE-GYELQVSRPEVIIKEIDGVKCEPFERVQIDTPEEYQGAII 421
G++ + + ++ + E+++ P VI E K E + I+ P A I
Sbjct: 391 LGKVQMEVTCALLQEKYHVEIEIKEPTVIYMERPLKKAE--YTIHIEVPPNPFWASI 445



Score = 42.5 bits (100), Expect = 4e-06
Identities = 18/79 (22%), Positives = 31/79 (39%), Gaps = 1/79 (1%)

Query: 403 EPFERVQIDTPEEYQGAIIQSLSERKGDMLDMQMVGNGQTRLIFLIPARGLIGYSTEFLS 462
EP+ +I P+EY + +++D Q + N + L IPAR + Y ++
Sbjct: 537 EPYLSFKIYAPQEYLSRAYTDAPKYCANIVDTQ-LKNNEVILSGEIPARCIQEYRSDLTF 595

Query: 463 MTRGYGIMNHTFDQYLPVV 481
T G + Y
Sbjct: 596 FTNGRSVCLTELKGYHVTT 614


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1365PF03309290.017 Bvg accessory factor
		>PF03309#Bvg accessory factor

Length = 271

Score = 29.3 bits (66), Expect = 0.017
Identities = 28/126 (22%), Positives = 42/126 (33%), Gaps = 14/126 (11%)

Query: 5 LLGIDLGGTTIKFGILTAAGEVQE---KWAIETNILEGGKHIVPDIIASIKHRLDLYDLS 61
LL ID+ T G+++ +G+ + +W I T + D +A L
Sbjct: 2 LLAIDVRNTHTVVGLISGSGDHAKVVQQWRIRTE-----PEVTADELALTIDG--LIGDD 54

Query: 62 SADFVGIGMGSPGAVDRDTNTVTGAFNLNWKETQEVGSVVEKELGIPFAIDNDANVAALG 121
+ G S V + V W V GIP +DN V A
Sbjct: 55 AERLTGASGLS--TVPSVLHEVRVMLEQYWPNVPHVLIEPGVRTGIPLLVDNPKEVGA-- 110

Query: 122 ERWVGA 127
+R V
Sbjct: 111 DRIVNC 116


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1367HELNAPAPROT1511e-49 Helicobacter neutrophil-activating protein A family ...
		>HELNAPAPROT#Helicobacter neutrophil-activating protein A family

signature.
Length = 153

Score = 151 bits (383), Expect = 1e-49
Identities = 49/154 (31%), Positives = 85/154 (55%), Gaps = 4/154 (2%)

Query: 19 KKEASKNEKT--KAVLNQAVADLSVAASIVHQVHWYMRGPGFLYLHPKMDELLDSLNANL 76
K E +K +T + LN +++ + S +H+ HWY++GP F LH K +EL D +
Sbjct: 2 KTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFFTLHEKFEELYDHAAETV 61

Query: 77 DEMSERLITIGGAPYSTLAEFSKHSKLDEAKGTYDKTVAQHLARLVEVYLYLSSLYQVGL 136
D ++ERL+ IGG P +T+ E+++H+ + + + + ++ + LV Y +SS + +
Sbjct: 62 DTIAERLLAIGGQPVATVKEYTEHASITDGGN--ETSASEMVQALVNDYKQISSESKFVI 119

Query: 137 DITDEEGDAGTNDLFTAAKTEAEKTIWMLQAERG 170
+ +E D T DLF E EK +WML + G
Sbjct: 120 GLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG 153


33MGAS10750_Spy1382MGAS10750_Spy1388N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy1382-3181.827742arginine deiminase
MGAS10750_Spy1383-3191.906544transcription regulator, crp family
MGAS10750_Spy1384-3202.631718arginine repressor, argR
MGAS10750_Spy1385-1182.545113hypothetical protein
MGAS10750_Spy13860182.169638hypothetical protein
MGAS10750_Spy1387-1202.156016two-component sensor kinase yesM
MGAS10750_Spy13880160.872665two-component response regulator yesN
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1382ARGDEIMINASE5780.0 Bacterial arginine deiminase signature.
		>ARGDEIMINASE#Bacterial arginine deiminase signature.

Length = 409

Score = 578 bits (1492), Expect = 0.0
Identities = 191/410 (46%), Positives = 276/410 (67%), Gaps = 9/410 (2%)

Query: 5 TPIHVYSEIGKLKKVLLHRPGKEIENLMPDYLERLLFDDIPFLEDAQKEHDAFAQALRDE 64
PI+++SEIG+LKKVLLHRPG+E+ENL P ++ LFDDIP+LE A++EH+ FA L++
Sbjct: 6 NPINIFSEIGRLKKVLLHRPGEELENLTPFIMKNFLFDDIPYLEVARQEHEVFASILKNN 65

Query: 65 GIEVLYLETLAAESLVTP-EIREAFIDEYLSEANIRGRATKKAIRELLMAIEDNQELIEK 123
+E+ Y+E L +E LV+ + FI +++ EA I+ T +++ ++ +I K
Sbjct: 66 LVEIEYIEDLISEVLVSSVALENKFISQFILEAEIKTDFTINLLKDYFSSL-TIDNMISK 124

Query: 124 TMAGVQKSELPEIPASEKGLTDLVESNYPFAIDPMPNLYFTRDPFATIGTGVSLNHMFSE 183
++GV EL +S L DLV F IDPMPN+ FTRDPFA+IG GV++N MF++
Sbjct: 125 MISGVVTEELKNYTSS---LDDLVNGANLFIIDPMPNVLFTRDPFASIGNGVTINKMFTK 181

Query: 184 TRNRETLYGKYIFTHHPIYGGGKVPMVYDRNETTRIEGGDELVLSKDVLAVGISQRTDAA 243
R RET++ +YIF +HP+Y VP+ +R E +EGGDELVL+K +L +GIS+RT+A
Sbjct: 182 VRQRETIFAEYIFKYHPVYKE-NVPIWLNRWEEASLEGGDELVLNKGLLVIGISERTEAK 240

Query: 244 SIEKLLVNIFKQNLGFKKVLAFEFANNRKFMHLDTVFTMVDYDKFTIHPEIEGDLRVYSV 303
S+EKL +++FK F +LAF+ NR +MHLDTVFT +DY FT + +Y +
Sbjct: 241 SVEKLAISLFKNKTSFDTILAFQIPKNRSYMHLDTVFTQIDYSVFTSFTSDDMYFSIYVL 300

Query: 304 TYDNE--ELHIVEEKGDLAELLAANLGVEKVDLIRCGGDNLVAAGREQWNDGSNTLTIAP 361
TY+ ++HI +EK + ++L+ LG K+D+I+C G +L+ REQWNDG+N L IAP
Sbjct: 301 TYNPSSSKIHIKKEKARIKDVLSFYLG-RKIDIIKCAGGDLIHGAREQWNDGANVLAIAP 359

Query: 362 GVVVVYNRNTITNAILESKGLKLIKIHGSELVRGRGGPRCMSMPFEREDI 411
G ++ Y+RN +TN + E G+K+ +I SEL RGRGGPRCMSMP REDI
Sbjct: 360 GEIIAYSRNHVTNKLFEENGIKVHRIPSSELSRGRGGPRCMSMPLIREDI 409


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1384ARGREPRESSOR1242e-39 Bacterial arginine repressor signature.
		>ARGREPRESSOR#Bacterial arginine repressor signature.

Length = 149

Score = 124 bits (314), Expect = 2e-39
Identities = 61/146 (41%), Positives = 92/146 (63%), Gaps = 2/146 (1%)

Query: 1 MNKKETRHQLIRSLISETTIHTQQELQERLQKNGITITQATLSRDMKELNLVKVTSGNDT 60
MNK + RH IR +I+ I TQ EL + L+K+G +TQAT+SRD+KEL+LVKV + N +
Sbjct: 1 MNKGQ-RHIKIREIITANEIETQDELVDILKKDGYNVTQATVSRDIKELHLVKVPTNNGS 59

Query: 61 HYEALAISQTRWEH-RLRFYMEDALVMLKIVQHQIILKTLPGLAQSFGSILDAMQIPEIV 119
+ +L Q +L+ + DA V + H I+LKT+PG AQ+ G+++D + EI+
Sbjct: 60 YKYSLPADQRFNPLSKLKRSLMDAFVKIDSASHLIVLKTMPGNAQAIGALMDNLDWEEIM 119

Query: 120 ATICGDDTCLIVCEDNEQAKACYETL 145
TICGDDT LI+C ++ K + +
Sbjct: 120 GTICGDDTILIICRTHDDTKVVQKKI 145


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1387PF065801821e-54 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 182 bits (464), Expect = 1e-54
Identities = 57/203 (28%), Positives = 101/203 (49%), Gaps = 10/203 (4%)

Query: 362 EKAIGQYRLQALASQINPHFLYNTLDTIIWMAEFNDSKRVVEVTKSLAKYFRLALNQGN- 420
+ +L AL +QINPHF++N L+ I + D + E+ SL++ R +L N
Sbjct: 155 ASMAQEAQLMALKAQINPHFMFNALNNIRALIL-EDPTKAREMLTSLSELMRYSLRYSNA 213

Query: 421 EYIRLADELDHVSQYLFIQKQRYGDKLSYEVQGLDVYADFVIPKLILQPLVENAIYHGIK 480
+ LADEL V YL + ++ D+L +E Q D +P +++Q LVEN I HGI
Sbjct: 214 RQVSLADELTVVDSYLQLASIQFEDRLQFENQINPAIMDVQVPPMLVQTLVENGIKHGIA 273

Query: 481 EVDRKGMIKVTVSDTAQHLMLTVWDNGKGIEDSSLTNSQSLLARGGVGLKNVDQRLKLHY 540
++ + G I + + + L V + G ++ ++ G GL+NV +RL++ Y
Sbjct: 274 QLPQGGKILLKGTKDNGTVTLEVENTGSLALKNTKEST-------GTGLQNVRERLQMLY 326

Query: 541 GEGYHMTIHSQSDQFTEIQLSLP 563
G + + + + + + +P
Sbjct: 327 GTEAQIKLSEKQGKVNAM-VLIP 348


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1388HTHFIS966e-25 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 96.1 bits (239), Expect = 6e-25
Identities = 42/165 (25%), Positives = 75/165 (45%), Gaps = 12/165 (7%)

Query: 3 SLLIVEDEYLIRQGIRSLVDFSQFKIDRVNEAENGQLAWDLFQKEPYDIVLTDINMPKLN 62
++L+ +D+ IR + + + + V N W D+V+TD+ MP N
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGY---DVRITSNAATLWRWIAAGDGDLVVTDVVMPDEN 61

Query: 63 GIQLAELIKEHAPQTHLVFLTGYDDFNYALSALKLGADDYLLKPFSKADVEDMLGKLRKK 122
L IK+ P ++ ++ + F A+ A + GA DYL KPF D+ +++G + +
Sbjct: 62 AFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPF---DLTELIGIIGRA 118

Query: 123 LDLSKKTETIQELVEQPQKEVSAIAMAIHE------QLADSDLTL 161
L K+ + E Q + + A+ E +L +DLTL
Sbjct: 119 LAEPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTL 163


34MGAS10750_Spy1586MGAS10750_Spy1593N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy1586-210-0.623863ferrichrome transport system permease fhuB
MGAS10750_Spy1587-211-1.020827ferrichrome-binding protein
MGAS10750_Spy1588-29-0.392232hypothetical protein
MGAS10750_Spy1589-210-0.197593Fe3+-siderophore transport protein
MGAS10750_Spy1590-1111.684391Immunogenic secreted protein
MGAS10750_Spy15911121.477256alanine racemase
MGAS10750_Spy15922121.3606874'-phosphopantetheinyl transferase
MGAS10750_Spy15932122.566610preprotein translocase subunit SecA
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1586TYPE3IMSPROT290.040 Type III secretion system inner membrane S protein ...
		>TYPE3IMSPROT#Type III secretion system inner membrane S protein

family signature.
Length = 354

Score = 28.6 bits (64), Expect = 0.040
Identities = 19/76 (25%), Positives = 32/76 (42%), Gaps = 5/76 (6%)

Query: 264 LASVATSIVGVVSFLGL---IVPHMSRLLVGSKHQILIPFSALLGAFVFLLADTLGRSLA 320
+ S A + +GL H S+L++ Q +PFS L V + L
Sbjct: 29 VVSTALIVALSAMLMGLSDYYFEHFSKLMLIPAEQSYLPFSQALSYVVDNVLLEFF-YLC 87

Query: 321 YPLEISPAIIMSIVGG 336
+PL ++ A +M+I
Sbjct: 88 FPL-LTVAALMAIASH 102


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1587FERRIBNDNGPP682e-15 Ferrichrome-binding periplasmic protein signature.
		>FERRIBNDNGPP#Ferrichrome-binding periplasmic protein signature.

Length = 296

Score = 68.4 bits (167), Expect = 2e-15
Identities = 56/266 (21%), Positives = 102/266 (38%), Gaps = 26/266 (9%)

Query: 29 VACVNQHPKTAKETEQQRIVATSVAVVDICDRLNLDLVGVCDSKLYTL----PKRYDAVK 84
+ A + RIVA V++ L + GV D+ Y L P D+V
Sbjct: 20 PLLWQMNTAHAAAIDPNRIVALEWLPVELLLALGIVPYGVADTINYRLWVSEPPLPDSVI 79

Query: 85 RVGLPMNPDIELIASLKPTWILSPNSLQEDLEPKYQKLDTEYGFLNLRSVEG------MY 138
VGL P++EL+ +KP++++ P + L +G
Sbjct: 80 DVGLRTEPNLELLTEMKPSFMV----WSAGYGPSPEMLARIAPGRGFNFSDGKQPLAMAR 135

Query: 139 QSIDDLGNLFQRQQEAKELRQQYQDYYRAFQAKRKGK-KKPKVLILMGLPGSYLVATNQS 197
+S+ ++ +L Q A+ QY+D+ R+ + + + +P +L + P LV S
Sbjct: 136 KSLTEMADLLNLQSAAETHLAQYEDFIRSMKPRFVKRGARPLLLTTLIDPRHMLVFGPNS 195

Query: 198 YVGNLLDLAGGENVYQSDEKEFLSANP---EDMLA-KEPDLILRTAHAIPDKVKVMFDKE 253
+LD G N +Q E F + + + A K+ D++ D +M
Sbjct: 196 LFQEILDEYGIPNAWQG-ETNFWGSTAVSIDRLAAYKDVDVLCFDHDNSKDMDALM---- 250

Query: 254 FAENDIWKHFTAVKEGKVYDLDNTLF 279
+W+ V+ G+ + F
Sbjct: 251 --ATPLWQAMPFVRAGRFQRVPAVWF 274


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1590TONBPROTEIN300.015 Gram-negative bacterial tonB protein signature.
		>TONBPROTEIN#Gram-negative bacterial tonB protein signature.

Length = 239

Score = 30.3 bits (68), Expect = 0.015
Identities = 14/42 (33%), Positives = 17/42 (40%)

Query: 117 KPTDHSKPTDQPKPTDQPKPSPSKVDTAPASSLSRQLPEVRT 158
KP KP K +QPK V++ PAS P T
Sbjct: 93 KPKPKPKPKPVKKVQEQPKRDVKPVESRPASPFENTAPARLT 134


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1591ALARACEMASE345e-120 Alanine racemase signature.
		>ALARACEMASE#Alanine racemase signature.

Length = 356

Score = 345 bits (888), Expect = e-120
Identities = 122/367 (33%), Positives = 194/367 (52%), Gaps = 21/367 (5%)

Query: 7 RPTVARVNLQAIKENVASVQKHIPLGVKTYAVVKADAYGHGAVQVSKALLPQVDGYCVSN 66
RP A ++LQA+K+N++ V++ + ++VVKA+AYGHG ++ A+ DG+ + N
Sbjct: 3 RPIQASLDLQALKQNLSIVRQAAT-HARVWSVVKANAYGHGIERIWSAI-GATDGFALLN 60

Query: 67 LDEALQLRQAGIDKEILIL-GVLLPNELKLAITRQVTVTVASLEWLAMAKQEWPDLKG-L 124
L+EA+ LR+ G IL+L G +L++ ++T V S L + LK L
Sbjct: 61 LEEAITLRERGWKGPILMLEGFFHAQDLEIYDQHRLTTCVHSNWQLKALQNA--RLKAPL 118

Query: 125 KVHIKIDSGMGRIGLRSVTEVDNLIAGLKSMGA-EVEGIFTHFATADEADDTKFNQQLQF 183
+++K++SGM R+G + V + L++M + +HFA A+ D +
Sbjct: 119 DIYLKVNSGMNRLGFQP-DRVLTVWQQLRAMANVGEMTLMSHFAEAEHPDGIS--GAMAR 175

Query: 184 FKKLIAGLEDKPRLVHASNSATSIWHSDTIFNAVRLGIVSYGLNPSGS-DLSLPFPLQEA 242
++ GL SNSA ++WH + F+ VR GI+ YG +PSG L+
Sbjct: 176 IEQAAEGL---ECRRSLSNSAATLWHPEAHFDWVRPGIILYGASPSGQWRDIANTGLRPV 232

Query: 243 LSLESSLVHVKMISAGDTVGYGATYTAKKSEYVGTVPIGYADGWTRNM-QGFSVLVDGQF 301
++L S ++ V+ + AG+ VGYG YTA+ + +G V GYADG+ R+ G VLVDG
Sbjct: 233 MTLSSEIIGVQTLKAGERVGYGGRYTARDEQRIGIVAAGYADGYPRHAPTGTPVLVDGVR 292

Query: 302 CEIIGRVSMDQLTIRLPKA--YPLGTKVTLIGSNQQKNISTTDIANYRNTINYEVLCLLS 359
+G VSMD L + L +GT V L G K I D+A T+ YE++C L+
Sbjct: 293 TMTVGTVSMDMLAVDLTPCPQAGIGTPVELWG----KEIKIDDVAAAAGTVGYELMCALA 348

Query: 360 DRIPRIY 366
R+P +
Sbjct: 349 LRVPVVT 355


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1593SECA10520.0 SecA protein signature.
		>SECA#SecA protein signature.

Length = 901

Score = 1052 bits (2723), Expect = 0.0
Identities = 394/903 (43%), Positives = 560/903 (62%), Gaps = 73/903 (8%)

Query: 1 MANILRKVIENDKG-ELRKLEKIAKKVESYADQMASLSDRDLQGKTLEFKERYQKGETLE 59
+ +L KV + LR++ K+ + + +M LSD +L+GKT EF+ R +KGE LE
Sbjct: 2 LIKLLTKVFGSRNDRTLRRMRKVVNIINAMEPEMEKLSDEELKGKTAEFRARLEKGEVLE 61

Query: 60 QLLPEAFAVVREAAKRVLGLFPYRVQIMGGIVLHNGDVPEMRTGEGKTLTATMPVYLNAI 119
L+PEAFAVVREA+KRV G+ + VQ++GG+VL+ + EMRTGEGKTLTAT+P YLNA+
Sbjct: 62 NLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNERCIAEMRTGEGKTLTATLPAYLNAL 121

Query: 120 AGEGVHVITVNEYLSTRDATEMGEVYSWLGLSVGINLAAKSPAEKREAYNCDITYSTNSE 179
G+GVHV+TVN+YL+ RDA ++ +LGL+VGINL KREAY DITY TN+E
Sbjct: 122 TGKGVHVVTVNDYLAQRDAENNRPLFEFLGLTVGINLPGMPAPAKREAYAADITYGTNNE 181

Query: 180 VGFDYLRDNMVVRQEDMVQRPLNFALVDEVDSVLIDEARTPLIVSGAVSSETNQLYIRAD 239
GFDYLRDNM E+ VQR L++ALVDEVDS+LIDEARTPLI+SG + ++Y R +
Sbjct: 182 YGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSS-EMYKRVN 240

Query: 240 MFVKTLT------------SVDYVIDVPTKTIGLSDSGIDKAESYFNLS-------NLYD 280
+ L + +D ++ + L++ G+ E +LY
Sbjct: 241 KIIPHLIRQEKEDSETFQGEGHFSVDEKSRQVNLTERGLVLIEELLVKEGIMDEGESLYS 300

Query: 281 IENVALTHFIDNALRANYIMLLDIDYVVSEDGEILIVDQFTGRTMEGRRFSDGLHQAIEA 340
N+ L H + ALRA+ + D+DY+V +DGE++IVD+ TGRTM+GRR+SDGLHQA+EA
Sbjct: 301 PANIMLMHHVTAALRAHALFTRDVDYIV-KDGEVIIVDEHTGRTMQGRRWSDGLHQAVEA 359

Query: 341 KEGVRIQEESKTSASITYQNMFRMYKKLAGMTGTAKTEEEEFREVYNMRIIPIPTNRPIA 400
KEGV+IQ E++T ASIT+QN FR+Y+KLAGMTGTA TE EF +Y + + +PTNRP+
Sbjct: 360 KEGVQIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMI 419

Query: 401 RIDHTDLLYPTLESKFRAVVEDVKTRHAKGQPILVGTVAVETSDLISRKLVEAGIPHEVL 460
R D DL+Y T K +A++ED+K R AKGQP+LVGT+++E S+L+S +L +AGI H VL
Sbjct: 420 RKDLPDLVYMTEAEKIQAIIEDIKERTAKGQPVLVGTISIEKSELVSNELTKAGIKHNVL 479

Query: 461 NAKNHFKEAQIIMNAGQRGAVTIATNMAGRGTDIKLG----------------------- 497
NAK H EA I+ AG AVTIATNMAGRGTDI LG
Sbjct: 480 NAKFHANEAAIVAQAGYPAAVTIATNMAGRGTDIVLGGSWQAEVAALENPTAEQIEKIKA 539

Query: 498 ------EGVRELGGLCVIGTERHESRRIDNQLRGRSGRQGDPGESQFYLSLEDDLMRRFG 551
+ V E GGL +IGTERHESRRIDNQLRGRSGRQGD G S+FYLS+ED LMR F
Sbjct: 540 DWQVRHDAVLEAGGLHIIGTERHESRRIDNQLRGRSGRQGDAGSSRFYLSMEDALMRIFA 599

Query: 552 SDRIKAFLDRMKLDEEDTVIKSGMLGRQVESAQKRVEGNNYDTRKQVLQYDDVMREQREI 611
SDR+ + ++ + + I+ + + + +AQ++VE N+D RKQ+L+YDDV +QR
Sbjct: 600 SDRVSGMMRKLGM-KPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRA 658

Query: 612 IYANRRDVITANRDLGPEIKAMIKRTIDRAVDAHARSNR---KDAVDAIVTFARTSLVPE 668
IY+ R +++ + D+ I ++ + +DA+ + + + +
Sbjct: 659 IYSQRNELLDVS-DVSETINSIREDVFKATIDAYIPPQSLEEMWDIPGLQERLKNDFDLD 717

Query: 669 ESIS--AKELRGLKDEQIKEKLYQRALAIYDQQLSKLRDQEAIIEFQKVLILMIVDNKWT 726
I+ + L +E ++E++ +++ +Y ++ + E + F+K ++L +D+ W
Sbjct: 718 LPIAEWLDKEPELHEETLRERILAQSIEVYQRKEEVVG-AEMMRHFEKGVMLQTLDSLWK 776

Query: 727 EHIDALDQLRNAVGLRGYAQNNPVVEYQAEGFKMFQDMIGAIEFDVTRTMMKAQIH-EQE 785
EH+ A+D LR + LRGYAQ +P EY+ E F MF M+ +++++V T+ K Q+ +E
Sbjct: 777 EHLAAMDYLRQGIHLRGYAQKDPKQEYKRESFSMFAAMLESLKYEVISTLSKVQVRMPEE 836

Query: 786 RERASQRATTAAPQNIQSQQSANTDD-------------LPKVERNEACPCGSGKKFKNC 832
E Q+ A + Q QQ ++ DD KV RN+ CPCGSGKK+K C
Sbjct: 837 VEELEQQRRMEAERLAQMQQLSHQDDDSAAAAALAAQTGERKVGRNDPCPCGSGKKYKQC 896

Query: 833 HGR 835
HGR
Sbjct: 897 HGR 899


35MGAS10750_Spy1774MGAS10750_Spy1781N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy1774-2173.951019Pullulanase
MGAS10750_Spy1773-2203.795708hypothetical protein
MGAS10750_Spy1775-2224.448216glucan 1,6-alpha-glucosidase
MGAS10750_Spy1776-1215.591737Multiple sugar transport ATP-binding protein
MGAS10750_Spy1777-2246.007073hypothetical protein
MGAS10750_Spy1778-3245.758943Streptokinase
MGAS10750_Spy1779-1226.366075D-tyrosyl-tRNA(Tyr) deacylase
MGAS10750_Spy1780-1226.322888GTP pyrophosphokinase /
MGAS10750_Spy17810216.496634Collagen-like surface protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1774GPOSANCHOR350.003 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 34.7 bits (79), Expect = 0.003
Identities = 24/96 (25%), Positives = 38/96 (39%), Gaps = 5/96 (5%)

Query: 1066 QAGVTAIAKPKGVQFTKEGLTIDSLTALVLKVSSKPADPSQKKSQTGNHQTKTPDGSKDL 1125
QA + A AK + K+ + L A S P K+ G Q +
Sbjct: 434 QAKLEAEAKALKEKLAKQAEELAKLRAGKASDSQTPDAKPGNKAVPGKGQAPQAGTKPNQ 493

Query: 1126 DKSLMTRPKRAQTNQKLPKTGEASSKGLLAAGVALL 1161
+K+ M KR +LP TGE ++ AA + ++
Sbjct: 494 NKAPMKETKR-----QLPSTGETANPFFTAAALTVM 524


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1776PF05272320.003 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 32.4 bits (73), Expect = 0.003
Identities = 14/56 (25%), Positives = 20/56 (35%), Gaps = 9/56 (16%)

Query: 34 IVFVGPSGCGKSTTLPMIAGLEDISEGELKIGGEVVNDKSPKDRDIAMVFQNYALY 89
+V G G GKST + + GL+ S+ IG +D Y
Sbjct: 599 VVLEGTGGIGKSTLINTLVGLDFFSDTHFDIG---------TGKDSYEQIAGIVAY 645


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1777HTHFIS347e-04 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 34.0 bits (78), Expect = 7e-04
Identities = 10/30 (33%), Positives = 19/30 (63%)

Query: 243 ALWSEHGNLVQTAQRLYIHRNSLQYKLDKF 272
AL + GN ++ A L ++RN+L+ K+ +
Sbjct: 444 ALTATRGNQIKAADLLGLNRNTLRKKIREL 473


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1778STREPKINASE7890.0 Streptococcus streptokinase protein signature.
		>STREPKINASE#Streptococcus streptokinase protein signature.

Length = 440

Score = 789 bits (2039), Expect = 0.0
Identities = 374/440 (85%), Positives = 398/440 (90%)

Query: 1 MKNYLSFGMFALLFALTFGTVKPVQAIAGPEWLLDRPSVNNIQLVVSVAGTVEGTNQEIS 60
MKNYLSFGMFALLFALTFGTV VQAIAGPEWLLDRPSVNN QLVVSVAGTVEGTNQ+IS
Sbjct: 1 MKNYLSFGMFALLFALTFGTVNSVQAIAGPEWLLDRPSVNNSQLVVSVAGTVEGTNQDIS 60

Query: 61 LKFFEIDLTSGPAQGGKTEQGLSPKSKPFATNKGAMPHKLEKADLLKAIQEQLIANVHSN 120
LKFFEIDLTS PA GGKTEQGLSPKSKPFAT+ GAM HKLEKADLLKAIQEQLIANVHSN
Sbjct: 61 LKFFEIDLTSRPAHGGKTEQGLSPKSKPFATDSGAMSHKLEKADLLKAIQEQLIANVHSN 120

Query: 121 DGYFEVIDFASDATITDRNGKVYFADRDDSVTLPTQPVQEFLLSGHVRVRPYQPKAVHNS 180
D YFEVIDFASDATITDRNGKVYFAD+D SVTLPTQPVQEFLLSGHVRVRPY+ K + N
Sbjct: 121 DDYFEVIDFASDATITDRNGKVYFADKDGSVTLPTQPVQEFLLSGHVRVRPYKEKPIQNQ 180

Query: 181 AERVNVNYEVSFVSETGDLDFTPLLRNQYQLTTLAVGDSLSSQELAAIAQFILSKKYPDY 240
A+ V+V Y V F D DF P L++ L TLA+GD+++SQEL A AQ IL+K +P Y
Sbjct: 181 AKSVDVEYTVQFTPLNPDDDFRPGLKDTKLLKTLAIGDTITSQELLAQAQSILNKNHPGY 240

Query: 241 IITKRDSSIVTHDNDIFRTILPMDQEFTYHIKDREQAYKANSKTGIVEKTNNTDLISEKY 300
I +RDSSIVTHDNDIFRTILPMDQEFTY +K+REQAY+ N K+G+ E+ NNTDLISEKY
Sbjct: 241 TIYERDSSIVTHDNDIFRTILPMDQEFTYRVKNREQAYRINKKSGLNEEINNTDLISEKY 300

Query: 301 YVLKKGEKPYDPFDRSHLKLFTINYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAK 360
YVLKKGEKPYDPFDRSHLKLFTI YVDV+TNELLKSEQLLTASERNLDFRDLYDPRDKAK
Sbjct: 301 YVLKKGEKPYDPFDRSHLKLFTIKYVDVDTNELLKSEQLLTASERNLDFRDLYDPRDKAK 360

Query: 361 LLYNNLDAFGIMDYTLTGKVEDNHNDTNRIITVYMGKRPEGENASYHLAYDKDRYTEEER 420
LLYNNLDAFGIMDYTLTGKVEDNH+DTNRIITVYMGKRPEGENASYHLAYDKDRYTEEER
Sbjct: 361 LLYNNLDAFGIMDYTLTGKVEDNHDDTNRIITVYMGKRPEGENASYHLAYDKDRYTEEER 420

Query: 421 EVYSYLRYTGTPIPDNPNDK 440
EVYSYLRYTGTPIPDNPNDK
Sbjct: 421 EVYSYLRYTGTPIPDNPNDK 440


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1781GPOSANCHOR635e-13 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 63.2 bits (153), Expect = 5e-13
Identities = 42/124 (33%), Positives = 53/124 (42%), Gaps = 3/124 (2%)

Query: 272 EKAPEKSPEVTPTPETPEQP---GEKAPEKSPEVTPTPETPEQPGEKAPEKSKEVTPAPE 328
K E+S ++T + Q E K E + KA +
Sbjct: 416 NKELEESKKLTEKEKAELQAKLEAEAKALKEKLAKQAEELAKLRAGKASDSQTPDAKPGN 475

Query: 329 KPADKEANQTPERRNGNMAKTPVANNHRRLPATGEQANPFFTAAAVAVMTTAGVLAVTKR 388
K + N K P+ R+LP+TGE ANPFFTAAA+ VM TAGV AV KR
Sbjct: 476 KAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETANPFFTAAALTVMATAGVAAVVKR 535

Query: 389 KENN 392
KE N
Sbjct: 536 KEEN 539


36MGAS10750_Spy1800MGAS10750_Spy1828N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
MGAS10750_Spy1800-2130.697083peptide ABC transporter ATP-binding protein
MGAS10750_Spy18011141.703747peptide ABC transporter ATP-binding protein
MGAS10750_Spy18020132.411469hypothetical protein
MGAS10750_Spy18031132.397168Streptococcal histidine triad protein
MGAS10750_Spy18044162.276914Streptococcal histidine triad protein
MGAS10750_Spy18056192.342967Laminin-binding surface protein
MGAS10750_Spy18066181.632644Fibronectin-binding protein
MGAS10750_Spy18076190.992033C5A peptidase precursor
MGAS10750_Spy18081021-0.283637M protein
MGAS10750_Spy18096211.250405M protein
MGAS10750_Spy18103210.986402M protein
MGAS10750_Spy18112220.712051trans-acting positive regulator Mry
MGAS10750_Spy18120241.244499hypothetical protein
MGAS10750_Spy1813-1231.409915Immunogenic protein
MGAS10750_Spy1814-1221.361881Immunogenic secreted protein
MGAS10750_Spy1815-122-0.072813two-component system histidine kinase
MGAS10750_Spy1816-2220.138063two-component response regulator
MGAS10750_Spy1817-1242.356783ABC transporter permease
MGAS10750_Spy18181161.967848ABC transporter ATP-binding protein
MGAS10750_Spy18192172.435644periplasmic component of efflux system
MGAS10750_Spy18202192.765084hypothetical protein
MGAS10750_Spy18212202.992654hypothetical protein
MGAS10750_Spy18222203.070565Fibronectin-binding protein
MGAS10750_Spy18232181.483263Fibronectin-binding protein
MGAS10750_Spy18242312.698948hypothetical protein
MGAS10750_Spy18252331.354237foldase PrsA
MGAS10750_Spy1826020-1.456374hypothetical protein
MGAS10750_Spy1827020-1.008732Streptopain precursor
MGAS10750_Spy1828020-1.522563Streptopain precursor
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1800HTHFIS290.022 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 29.0 bits (65), Expect = 0.022
Identities = 9/16 (56%), Positives = 12/16 (75%)

Query: 45 IIGASGSGKSLLAHAI 60
I G SG+GK L+A A+
Sbjct: 165 ITGESGTGKELVARAL 180


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1803PF05616340.002 Neisseria meningitidis TspB protein
		>PF05616#Neisseria meningitidis TspB protein

Length = 501

Score = 34.0 bits (77), Expect = 0.002
Identities = 24/87 (27%), Positives = 35/87 (40%), Gaps = 2/87 (2%)

Query: 41 IPKKDLSPSELAAAQAYWSQKQGRGARPSDY-RPTPAPGRRKAPIPDVTPNPGQGHQPD- 98
IP+ DL+P A A + P++ P PG R P PD NP D
Sbjct: 310 IPRPDLTPGSAEAPNAQPLPEVSPAENPANNPAPNENPGTRPNPEPDPDLNPDANPDTDG 369

Query: 99 NGGYHPAPPRPNDASQNKHQRDEFKGK 125
G P P D +H+++ +G+
Sbjct: 370 QPGTRPDSPAVPDRPNGRHRKERKEGE 396


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1805ADHESNFAMILY2473e-83 Adhesin family signature.
		>ADHESNFAMILY#Adhesin family signature.

Length = 309

Score = 247 bits (633), Expect = 3e-83
Identities = 82/323 (25%), Positives = 143/323 (44%), Gaps = 34/323 (10%)

Query: 1 MKKGFFLMAMAVSLVMIAGCDKSANPKQPTQGMSVVTSFYPMYAMTKEVSGDLNDVR-MI 59
MKK L+ + +S +++ C Q + VV + + +TK ++GD D+ ++
Sbjct: 1 MKKLGTLLVLFLSAIILVACASGKKDTTSGQKLKVVATNSIIADITKNIAGDKIDLHSIV 60

Query: 60 QSGAGIHSFEPSVNDVAAIYDADLFVYHSHTLE----AWARDLDPNLKKSKVDVFEASKP 115
G H +EP DV +ADL Y+ LE AW L N KK++ + A
Sbjct: 61 PIGQDPHEYEPLPEDVKKTSEADLIFYNGINLETGGNAWFTKLVENAKKTENKDYFA--- 117

Query: 116 LTLDRVKGLEDMEVTQGIDPATLY--------DPHTWTDPVLAGEEAVNIAKELGRLDPK 167
V+ G+D L DPH W + A NIAK+L DP
Sbjct: 118 -------------VSDGVDVIYLEGQNEKGKEDPHAWLNLENGIIFAKNIAKQLSAKDPN 164

Query: 168 HKDSYTKKAKAFKKEAEQLTEEYTQKFKKVR--SKTFVTQHTAFSYLAKRFGLKQLGISG 225
+K+ Y K K + + ++L +E KF K+ K VT AF Y +K +G+ I
Sbjct: 165 NKEFYEKNLKEYTDKLDKLDKESKDKFNKIPAEKKLIVTSEGAFKYFSKAYGVPSAYIWE 224

Query: 226 ISPEQEPSPRQLKEIQDFVKEYNVKTIFAEDNVNPKIAHAIAKSTGAKVKT---LSPLEA 282
I+ E+E +P Q+K + + +++ V ++F E +V+ + +++ T + +
Sbjct: 225 INTEEEGTPEQIKTLVEKLRQTKVPSLFVESSVDDRPMKTVSQDTNIPIYAQIFTDSIAE 284

Query: 283 APSGNKTYLENLRANLEVLYQQL 305
+Y ++ NL+ + + L
Sbjct: 285 QGKEGDSYYSMMKYNLDKIAEGL 307


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1806IGASERPTASE423e-06 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 41.6 bits (97), Expect = 3e-06
Identities = 37/249 (14%), Positives = 76/249 (30%), Gaps = 27/249 (10%)

Query: 37 AVDSIPPISLTQRTPATTSEKWHHIDDKGSIPLGISLEAAKKDFKEEVEKSRLSEEQKQT 96
VD P TP+ T+E ++ + ++ E + +E Q
Sbjct: 1019 RVDEAPVPPPAPATPSETTET-------------VAENSKQESKTVEKNEQDATETTAQ- 1064

Query: 97 YNQKIDAETDKDELLSTYHRDYLTAVKNLPTSTEPVEASVQETQASVSDSMVTGDSTSVT 156
+ A+ K + + + + + T+ E T + V + T
Sbjct: 1065 --NREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETKETATVEKEEKAKVETEKTQ-- 1120

Query: 157 ADSPKESPVAPASSPESEDSSVASSEETSSPETPVAPETPEEPAAPSPSPESEEPSVAAS 216
+ V SP+ E S + + E +EP + + + E +
Sbjct: 1121 ----EVPKVTSQVSPKQEQSETVQPQAEPARE-NDPTVNIKEPQSQTNTTADTEQPAKET 1175

Query: 217 SEETPTPSTPEEPA----APSPSPESEEPSVAASSEETPTPSTPEEPAAPSPSPESEDSS 272
S P T + +PE+ P+ + + + + P+ S +
Sbjct: 1176 SSNVEQPVTESTTVNTGNSVVENPENTTPATTQPTVNSESSNKPKNRHRRSVRSVPHNVE 1235

Query: 273 VAATTSPSP 281
A T+S
Sbjct: 1236 PATTSSNDR 1244



Score = 35.4 bits (81), Expect = 2e-04
Identities = 36/195 (18%), Positives = 72/195 (36%), Gaps = 13/195 (6%)

Query: 90 SEEQKQTYNQKIDAETDKDELLSTYHRDYLTAVKNLPTSTEPVEASVQE-TQASVSDSMV 148
S ++D +T T +N ++ VE + Q+ T+ + + V
Sbjct: 1009 SVPSNNEEIARVDEAPVPPPAPATPSETTETVAENSKQESKTVEKNEQDATETTAQNREV 1068

Query: 149 TGDSTSVTADSPKESPVAPASSPESEDSSVASSEETSSPETPVAPETPEEPAAPSPSPES 208
++ S + + + VA + S E++++ ++ET++ E EE A
Sbjct: 1069 AKEAKSNVKANTQTNEVAQSGS-ETKETQTTETKETATVEK-------EEKAKVETEKTQ 1120

Query: 209 EEPSVAASSEETPTPSTPEEPAAPSPSPESEEPSVAASSEETPTPSTPEEPA----APSP 264
E P V + S +P A ++ +T T + E+PA +
Sbjct: 1121 EVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQTNTTADTEQPAKETSSNVE 1180

Query: 265 SPESEDSSVAATTSP 279
P +E ++V S
Sbjct: 1181 QPVTESTTVNTGNSV 1195



Score = 28.5 bits (63), Expect = 0.033
Identities = 15/75 (20%), Positives = 27/75 (36%), Gaps = 5/75 (6%)

Query: 203 SPSPESEEPSVAASSEETPTPSTPEEPAAPSPSPESEEPSVAASSEETPTPSTPEEPAAP 262
+P E +V ++ TP + P+ PS + E +A E P P P+
Sbjct: 982 NPEVEKRNQTVDTTNITTPNNIQADVPSVPSNNEE-----IARVDEAPVPPPAPATPSET 1036

Query: 263 SPSPESEDSSVAATT 277
+ + + T
Sbjct: 1037 TETVAENSKQESKTV 1051


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1807SUBTILISIN1073e-27 Subtilisin serine protease family (S8) signature.
		>SUBTILISIN#Subtilisin serine protease family (S8) signature.

Length = 326

Score = 107 bits (269), Expect = 3e-27
Identities = 50/226 (22%), Positives = 85/226 (37%), Gaps = 47/226 (20%)

Query: 118 KAGKGAGTVVAVIDAGFDKNHEAWRLTDKSKARYQSKEDLEKAKKDHGITYGEWVNDKVA 177
+G G VAV+D G D +H DL KA+ G + +
Sbjct: 36 NQTRGRGVKVAVLDTGCDADHP----------------DL-KARIIGGRNFTDDDEGDPE 78

Query: 178 YYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLA 237
+ DY+ HGTHV+G ++ + G PEA LL+++V G
Sbjct: 79 IFKDYNG---------HGTHVAGTIAATENE-----NGVVGVAPEADLLIIKVLNKQGSG 124

Query: 238 DYARNYAQAIRDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGND 297
Y Q I A+ +I+MS G E +A A + + ++ +AGN+
Sbjct: 125 QYD-WIIQGIYYAIEQKVDIISMSLGGPED-----VPELHEAVKKAVASQILVMCAAGNE 178

Query: 298 SSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETAT 343
+T +G P + ++V + + D+ +E +
Sbjct: 179 GDGDDRT----------DELGYPGCYNEVISVGAINFDRHASEFSN 214



Score = 79.9 bits (197), Expect = 5e-18
Identities = 37/139 (26%), Positives = 58/139 (41%), Gaps = 22/139 (15%)

Query: 458 NATPKVLPTASGTK---LSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSM 514
+V+ + S FS+ + D+ APG+DILS+V KYA SGTSM
Sbjct: 192 GCYNEVISVGAINFDRHASEFSNSNN------EVDLVAPGEDILSTVPGGKYATFSGTSM 245

Query: 515 SAPLVAGIMGL-LQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGA 573
+ P VAG + L Q + D+T E L+ L + SP+ +G
Sbjct: 246 ATPHVAGALALIKQLANASFERDLTEPE----LYAQLIKRTIPLGN-------SPKMEGN 294

Query: 574 GAVDAKKASA-ATMYVTDK 591
G + + ++ T +
Sbjct: 295 GLLYLTAVEELSRIFDTQR 313


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1808GPOSANCHOR1172e-31 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 117 bits (293), Expect = 2e-31
Identities = 151/314 (48%), Positives = 202/314 (64%), Gaps = 20/314 (6%)

Query: 28 KAKYDALRDENTGLRGDRTKLLKKLEEEQEKSKNLEKQKQELENQALNFHDVIETQEKEK 87
+ + + +T L + + + LEK + N + I+T E EK
Sbjct: 231 EKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEK 290

Query: 88 EDLKTTLAKTTKENEISEASRKGLSSDLEASRAAKKELEAKHQKLEAENKKLTEANQVSE 147
L+ A ++++ A+R+ L DL+ASR AKK+LEA+HQKLE E N++SE
Sbjct: 291 AALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLE-------EQNKISE 343

Query: 148 ASRKGLSNDLEASRAAKKELEAKHQKLEADYQVSETSRKGLSRDLEASREANKKVTSELT 207
ASR+ L DL+ASR AKK+LEA+HQKLE ++SE SR+ L RDL+ASREA K+V L
Sbjct: 344 ASRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQVEKALE 403

Query: 208 QAKAQLSALE-------ESKKLSEKEKAELQAKLDAQGKALKEQLAKQTEELAKLRAEKA 260
+A ++L+ALE ESKKL+EKEKAELQAKL+A+ KALKE+LAKQ EELAKLRA KA
Sbjct: 404 EANSKLAALEKLNKELEESKKLTEKEKAELQAKLEAEAKALKEKLAKQAEELAKLRAGKA 463

Query: 261 AGSKTPATKPANKERSGR--AAQTATRPSQNKG----MRSQLPSTGEAANPFFTAAAATV 314
+ S+TP KP NK G+ A Q T+P+QNK + QLPSTGE ANPFFTAAA TV
Sbjct: 464 SDSQTPDAKPGNKAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETANPFFTAAALTV 523

Query: 315 MVSAGMLALKRKEE 328
M +AG+ A+ +++E
Sbjct: 524 MATAGVAAVVKRKE 537



Score = 52.8 bits (126), Expect = 9e-10
Identities = 51/250 (20%), Positives = 91/250 (36%), Gaps = 11/250 (4%)

Query: 1 MTVLGAGFANQTEVRAEGVKATTNLPEKAKYDALRDENTGLRGDRTKLLKKLEEEQEKSK 60
+TVLGAG T + + + + +++ + L K + +K
Sbjct: 26 LTVLGAGLVVNTNEVSAVATRS----QTDTLEKVQERADKFEIENNTLKLKNSDLSFNNK 81

Query: 61 NLEKQKQELENQALNFHDVIETQEKEKEDLKTTLAKTTKENEISEASRKGLSSDLEASRA 120
L+ EL + + +++ +L++ + + EA + L LE +
Sbjct: 82 ALKDHNDELTEE-------LSNAKEKLRKNDKSLSEKASKIQELEARKADLEKALEGAMN 134

Query: 121 AKKELEAKHQKLEAENKKLTEANQVSEASRKGLSNDLEASRAAKKELEAKHQKLEADYQV 180
AK + LEAE L E + +G N A A K LEA+ LEA
Sbjct: 135 FSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAE 194

Query: 181 SETSRKGLSRDLEASREANKKVTSELTQAKAQLSALEESKKLSEKEKAELQAKLDAQGKA 240
E + +G A K + +E A+ + LE++ + + AK+
Sbjct: 195 LEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAE 254

Query: 241 LKEQLAKQTE 250
A+Q E
Sbjct: 255 KAALEARQAE 264



Score = 40.4 bits (94), Expect = 7e-06
Identities = 50/211 (23%), Positives = 83/211 (39%)

Query: 11 QTEVRAEGVKATTNLPEKAKYDALRDENTGLRGDRTKLLKKLEEEQEKSKNLEKQKQELE 70
+ A+ L G T K++ + + LE ++ ELE
Sbjct: 137 TADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELE 196

Query: 71 NQALNFHDVIETQEKEKEDLKTTLAKTTKENEISEASRKGLSSDLEASRAAKKELEAKHQ 130
+ + + L+ A E + +G + A A K LEA+
Sbjct: 197 KALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKA 256

Query: 131 KLEAENKKLTEANQVSEASRKGLSNDLEASRAAKKELEAKHQKLEADYQVSETSRKGLSR 190
LEA +L +A + + S ++ A K LEA+ LE QV +R+ L R
Sbjct: 257 ALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRR 316

Query: 191 DLEASREANKKVTSELTQAKAQLSALEESKK 221
DL+ASREA K++ +E + + Q E S++
Sbjct: 317 DLDASREAKKQLEAEHQKLEEQNKISEASRQ 347



Score = 37.7 bits (87), Expect = 5e-05
Identities = 51/232 (21%), Positives = 83/232 (35%)

Query: 30 KYDALRDENTGLRGDRTKLLKKLEEEQEKSKNLEKQKQELENQALNFHDVIETQEKEKED 89
K L L + + K K LE +K L + + +E
Sbjct: 114 KIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTA 173

Query: 90 LKTTLAKTTKENEISEASRKGLSSDLEASRAAKKELEAKHQKLEAENKKLTEANQVSEAS 149
+ E EA + L LE + AK + LEAE L E +
Sbjct: 174 DSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKA 233

Query: 150 RKGLSNDLEASRAAKKELEAKHQKLEADYQVSETSRKGLSRDLEASREANKKVTSELTQA 209
+G N A A K LEA+ LEA E + +G A K + +E
Sbjct: 234 LEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAAL 293

Query: 210 KAQLSALEESKKLSEKEKAELQAKLDAQGKALKEQLAKQTEELAKLRAEKAA 261
+A+ + LE ++ + L+ LDA +A K+ A+ + + + +A+
Sbjct: 294 EAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEAS 345



Score = 37.7 bits (87), Expect = 5e-05
Identities = 51/238 (21%), Positives = 86/238 (36%), Gaps = 10/238 (4%)

Query: 33 ALRDENTGLRGDRTKLLKKLEEEQEKSKNLEKQKQELENQALNFHDVIETQEKEKEDLKT 92
+++ ++ K++E + + +LEK + N + I+T E EK L
Sbjct: 96 NAKEKLRKNDKSLSEKASKIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAA 155

Query: 93 TLAKTTKENEISEASRKGLSSDLEASRAAKKELEAKHQKLEAENKKLTEANQVSEASRKG 152
A K E + S+ ++ A K LEA+ +LE + + A K
Sbjct: 156 RKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKT 215

Query: 153 LSNDLEASRAAKKELEAKHQKLEADYQVSETSRKGLSRDLEASREANKKVTSELTQAKAQ 212
L + A A K +LE + K L + A ++ L A
Sbjct: 216 LEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNF 275

Query: 213 LSALEESKKLSEKEKAELQAKL----------DAQGKALKEQLAKQTEELAKLRAEKA 260
+A K E EKA L+A+ +A ++L+ L E +L AE
Sbjct: 276 STADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQ 333


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1809GPOSANCHOR1002e-25 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 100 bits (250), Expect = 2e-25
Identities = 148/308 (48%), Positives = 193/308 (62%), Gaps = 28/308 (9%)

Query: 64 KENEELKVEREKYLSYADDKEKDPQYRALMGENQDLRKREGQYQDKIEELEKERKEKQER 123
N + A+ + + L + KI+ LE E+ +
Sbjct: 237 AMNFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAE 296

Query: 124 QEQLERQYQIE--ADKHYQEQQKKHQQEQQQLEAEKQKLAKDKQISDASRQGLSRDLEAS 181
+ LE Q Q+ + + ++ ++QLEAE QKL + +IS+ASRQ L RDL+AS
Sbjct: 297 KADLEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDAS 356

Query: 182 REAKKKVEADLAALTAEHQKLKEDKQISDASRQGLSRDLEASREAKKKVEADLAEANSKL 241
REAKK++EA EHQKL+E +IS+ASRQ L RDL+ASREAKK+VE L EANSKL
Sbjct: 357 REAKKQLEA-------EHQKLEEQNKISEASRQSLRRDLDASREAKKQVEKALEEANSKL 409

Query: 242 QALEKLNKELEEGKKLSEKEKAELQARLEAEAKALKEQLAKQAEELAKLK-----GNQTP 296
ALEKLNKELEE KKL+EKEKAELQA+LEAEAKALKE+LAKQAEELAKL+ +QTP
Sbjct: 410 AALEKLNKELEESKKLTEKEKAELQAKLEAEAKALKEKLAKQAEELAKLRAGKASDSQTP 469

Query: 297 NAKVAPQA--------------NRSRSAMTQQKRTLPSTGETANPFFTAAAATVMVSAGM 342
+AK +A N++++ M + KR LPSTGETANPFFTAAA TVM +AG+
Sbjct: 470 DAKPGNKAVPGKGQAPQAGTKPNQNKAPMKETKRQLPSTGETANPFFTAAALTVMATAGV 529

Query: 343 LALKRKEE 350
A+ +++E
Sbjct: 530 AAVVKRKE 537



Score = 69.7 bits (170), Expect = 4e-15
Identities = 77/320 (24%), Positives = 122/320 (38%), Gaps = 4/320 (1%)

Query: 1 MARKDTNKQYSLRKLKTGTASVAVAVAVLGAGFANQTEVKAAEIKKPQADSAWNWPKEYN 60
M + +TN+ YSLRKLKTGTASVAVA+ VLGAG T +A + Q D+ + +
Sbjct: 1 MTKNNTNRHYSLRKLKTGTASVAVALTVLGAGLVVNTNEVSAVATRSQTDTLEKVQERAD 60

Query: 61 ALLKENEELKVEREKYLSYADDKEKDPQYRALMGENQDLRKREGQYQDKIEELEKERKEK 120
EN LK++ + L E + +++ + + E + +E
Sbjct: 61 KFEIENNTLKLKNSDLSFNNKALKD--HNDELTEELSNAKEKLRKNDKSLSEKASKIQEL 118

Query: 121 QERQEQLERQYQI--EADKHYQEQQKKHQQEQQQLEAEKQKLAKDKQISDASRQGLSRDL 178
+ R+ LE+ + + K + E+ L A K L K + + S +
Sbjct: 119 EARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKI 178

Query: 179 EASREAKKKVEADLAALTAEHQKLKEDKQISDASRQGLSRDLEASREAKKKVEADLAEAN 238
+ K +EA A L + A + L + A K +E L A
Sbjct: 179 KTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAM 238

Query: 239 SKLQALEKLNKELEEGKKLSEKEKAELQARLEAEAKALKEQLAKQAEELAKLKGNQTPNA 298
+ A K LE K E +AEL+ LE AK A+ + A
Sbjct: 239 NFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKA 298

Query: 299 KVAPQANRSRSAMTQQKRTL 318
+ Q+ + +R L
Sbjct: 299 DLEHQSQVLNANRQSLRRDL 318



Score = 31.6 bits (71), Expect = 0.005
Identities = 52/234 (22%), Positives = 90/234 (38%), Gaps = 21/234 (8%)

Query: 57 KEYNALLKENEELKVEREKYLSYADDKEKDPQY-----RALMGENQDLRKREGQYQDKIE 111
A + + L+ E+ + D EK + A + + L + + +
Sbjct: 134 NFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEAEKAALEARQA 193

Query: 112 ELEKERKEKQERQEQLERQYQIEADKH----------------YQEQQKKHQQEQQQLEA 155
ELEK + + + + + + LEA
Sbjct: 194 ELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLEA 253

Query: 156 EKQKLAKDKQISDASRQGLSRDLEASREAKKKVEADLAALTAEHQKLKEDKQISDASRQG 215
EK L + + + +G A K +EA+ AAL AE L+ Q+ +A+RQ
Sbjct: 254 EKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQS 313

Query: 216 LSRDLEASREAKKKVEADLAEANSKLQALEKLNKELEEGKKLSEKEKAELQARL 269
L RDL+ASREAKK++EA+ + + + E + L S + K +L+A
Sbjct: 314 LRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQLEAEH 367


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1810GPOSANCHOR1292e-35 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 129 bits (326), Expect = 2e-35
Identities = 117/346 (33%), Positives = 176/346 (50%), Gaps = 16/346 (4%)

Query: 57 KEANKVFEERKALEKQARDLGDTINHMSQTISEQSRKIAALKSEAELKNQQALEALNNKN 116
E K E T+ ++ + + A + +
Sbjct: 193 AELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIKTLE 252

Query: 117 KQISDLTNENAQLKEAIEGYVQ-------TIQNASREIAAKQQELAAAKSQLEAKNAEIE 169
+ + L A+L++A+EG + I+ E AA + E A + Q + NA +
Sbjct: 253 AEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQ 312

Query: 170 ALKQQDASKTEEIAKLQSEAATLENLLGSAKRELTELQAKLDTATAEKAKLESQVTTLEN 229
+L++ + E +L++E LE ++ L+ LD + K +LE++ LE
Sbjct: 313 SLRRDLDASREAKKQLEAEHQKLEEQNKISEASRQSLRRDLDASREAKKQLEAEHQKLEE 372

Query: 230 LLGSAKRELTDLQAKLDAANAEKEKLQSQAATLEKQLEATKKELADLQAKLAATNQEKE- 288
++ L+ LDA+ K++++ +L A +K +L+ T +EK
Sbjct: 373 QNKISEASRQSLRRDLDASREAKKQVEKALEEANSKLAALEKLNKELEESKKLTEKEKAE 432

Query: 289 ---KLEAEAKALKEQLAKQAEELAKLKADKASGAQKPDTKPGNKEVPTR----PSQTRTN 341
KLEAEAKALKE+LAKQAEELAKL+A KAS +Q PD KPGNK VP + + T+ N
Sbjct: 433 LQAKLEAEAKALKEKLAKQAEELAKLRAGKASDSQTPDAKPGNKAVPGKGQAPQAGTKPN 492

Query: 342 TNKAPMAQTKRQLPSTGEETTNPFFTAAALTVIASAGVLALKRKEE 387
NKAPM +TKRQLPSTG ET NPFFTAAALTV+A+AGV A+ +++E
Sbjct: 493 QNKAPMKETKRQLPSTG-ETANPFFTAAALTVMATAGVAAVVKRKE 537



Score = 86.7 bits (214), Expect = 1e-20
Identities = 93/334 (27%), Positives = 149/334 (44%), Gaps = 19/334 (5%)

Query: 1 MSKRNPNKLYSLRKLKTGTASVAVALTVLGTGLANTTDVKAESRRYQAPPRVLLQGKEAN 60
M+K N N+ YSLRKLKTGTASVAVALTVLG GL T+ + + + A+
Sbjct: 1 MTKNNTNRHYSLRKLKTGTASVAVALTVLGAGLVVNTNEVSAVATRSQTDTLEKVQERAD 60

Query: 61 KVFEERKALEKQARDLGDTINHMSQTISEQSRKIAALKSEAELKNQQALEALNNKNKQIS 120
K E L+ + DL + E + +++ K + KN ++L +K +++
Sbjct: 61 KFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLR-KNDKSLSEKASKIQELE 119

Query: 121 DLTNENAQLKEAIEGYVQTIQNASREIAAKQQELAAAKSQLEAKNAEIEALKQQDASKTE 180
+ + E + + + A++ LAA K+ LE D++K +
Sbjct: 120 ARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMNFSTADSAKIK 179

Query: 181 EI----AKLQSEAATLENLLGSAKRELTELQAKLDTATAEKAKLESQVTTLENLLGSAKR 236
+ A L++ A LE L A T AK+ T AEKA L ++ LE L A
Sbjct: 180 TLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAMN 239

Query: 237 ELTDLQAKLDAANAEKEKLQSQAATLEK--------------QLEATKKELADLQAKLAA 282
T AK+ AEK L+++ A LEK +++ + E A L+A+ A
Sbjct: 240 FSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALEAEKAD 299

Query: 283 TNQEKEKLEAEAKALKEQLAKQAEELAKLKADKA 316
+ + L A ++L+ L E +L+A+
Sbjct: 300 LEHQSQVLNANRQSLRRDLDASREAKKQLEAEHQ 333



Score = 29.6 bits (66), Expect = 0.022
Identities = 34/203 (16%), Positives = 74/203 (36%)

Query: 123 TNENAQLKEAIEGYVQTIQNASREIAAKQQELAAAKSQLEAKNAEIEALKQQDASKTEEI 182
T+ +++E + + + + A K + E+ K++ + +
Sbjct: 49 TDTLEKVQERADKFEIENNTLKLKNSDLSFNNKALKDHNDELTEELSNAKEKLRKNDKSL 108

Query: 183 AKLQSEAATLENLLGSAKRELTELQAKLDTATAEKAKLESQVTTLENLLGSAKRELTDLQ 242
++ S+ LE ++ L +A+ LE++ L ++ L
Sbjct: 109 SEKASKIQELEARKADLEKALEGAMNFSTADSAKIKTLEAEKAALAARKADLEKALEGAM 168

Query: 243 AKLDAANAEKEKLQSQAATLEKQLEATKKELADLQAKLAATNQEKEKLEAEAKALKEQLA 302
A +A+ + L+++ A LE + +K L A + + + LEAE AL + A
Sbjct: 169 NFSTADSAKIKTLEAEKAALEARQAELEKALEGAMNFSTADSAKIKTLEAEKAALAARKA 228

Query: 303 KQAEELAKLKADKASGAQKPDTK 325
+ L + + K T
Sbjct: 229 DLEKALEGAMNFSTADSAKIKTL 251


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1811PF050435360.0 Transcriptional activator
		>PF05043#Transcriptional activator

Length = 493

Score = 536 bits (1383), Expect = 0.0
Identities = 107/491 (21%), Positives = 217/491 (44%), Gaps = 16/491 (3%)

Query: 16 RELKLISYLTENSNVIGVKDKELSKALNISMLTLQSCLTNMQFMKEVGGITYKDGYINIW 75
R+L+L+ L E+ EL++ LN + ++ L++++ I I
Sbjct: 11 RQLELLELLFEHKRWFHRS--ELAELLNCTERAVKDDLSHVKSAFPDLIFHSSTNGIRII 68

Query: 76 YHQCCGLQEVYQKALRESPSLKLLELLFFRDFSSLEELAEELFVSLSTLKRLIKKTNTYL 135
++ VY + S +LE +FF + E + +E ++S S+L R+I + N +
Sbjct: 69 NTDDSDIEMVYHHFFKHSTHFSILEFIFFNEGCQAESICKEFYISSSSLYRIISQINKVI 128

Query: 136 SHTFAISIVTSPVQVSGDERQIRLFYLKYFSEAYKISEWPFGDILNLKNCERLLSLLIKE 195
F + +PVQ+ G+ER IR F+ +YFSE Y EWPF + + + +LL L+ KE
Sbjct: 129 KRQFQFEVSLTPVQIIGNERDIRYFFAQYFSEKYYFLEWPFEN-FSSEPLSQLLELVYKE 187

Query: 196 VDVKVHFTLFQHLKILSGVNLIRYYKGYSCSYNNKKTSHRFSQLIQHSSEIQDLSRLFYL 255
++ + + LK+L NL R G+ + + + + + I+ +++ F
Sbjct: 188 TSFPMNLSTHRMLKLLLVTNLYRIKFGHFMEVDKDSFNDQSLDFLMQAEGIEGVAQSFES 247

Query: 256 KFGLHLDEYTIAEMLSNHLNDKLEIGCAFEIINQDPTSGGRQVTNWIHLL----DEMEIK 311
++ + LDE + ++ ++ I E + V HLL D++ +K
Sbjct: 248 EYNISLDEEVVCQLFVSYFQKMFFID---ESLFMKCVKKDSYVEKSYHLLSDFIDQISVK 304

Query: 312 LNLSITNKYEVAVTLHNASVLNEEDITANYLLFDYKKSYLNFYQKEHPRIYEAFVTSVEK 371
+ I NK + LHN + L +++ ++LFD K + + +Q P+ +
Sbjct: 305 YQIEIENKDNLIWHLHNTAHLYRQELFTEFILFDQKGNTIRNFQNIFPKFVSDVKKELSH 364

Query: 372 LMQADNAQVSKELINQLTYCFFITWENSFLKVNQKDEKVRLLVI----ERSYNSVGNFLK 427
++ S ++N L+Y F ++ + + Q K+++LV+ + V L
Sbjct: 365 YLETLEVCSSSMMVNHLSYTFITHTKHLVINLLQNQPKLKVLVMSNFDQYHAKFVAETLS 424

Query: 428 KYIGEFFSITNFDELDCLTIDLVEIEKQYDVIVTDVMVGKSEELEIFFFYKMIPEAIIDR 487
Y F + + EL+ L + YD+I+++ ++ E + + + ++I
Sbjct: 425 YYCSNNFELEVWTELELSKESLE--DSPYDIIISNFIIPPIENKRLIYSNNINTVSLIYL 482

Query: 488 LNEFLNVSFTD 498
LN + + +
Sbjct: 483 LNAMMFIRLDE 493


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1814PF03544354e-04 Gram-negative bacterial tonB protein
		>PF03544#Gram-negative bacterial tonB protein

Length = 243

Score = 35.3 bits (81), Expect = 4e-04
Identities = 15/74 (20%), Positives = 18/74 (24%), Gaps = 2/74 (2%)

Query: 119 PSPKDQSSQKESQNKDGRPTPSPDQQKDQTPDKTPEKSADKAPEKGPEKAVEKTPEPNRD 178
P+P Q P Q P PE + PE E V +
Sbjct: 44 PAP-AQPISVTMVAPADLEPP-QAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKP 101

Query: 179 TPKPIQPPLAAAAP 192
PKP
Sbjct: 102 KPKPKPVKKVEQPK 115



Score = 32.6 bits (74), Expect = 0.003
Identities = 14/87 (16%), Positives = 23/87 (26%), Gaps = 4/87 (4%)

Query: 111 PNSSDQSTPSPKDQSSQKESQNKDGRPTPSPDQQKDQTPDKTPEKSADKAPEKGPE---- 166
P T ++ P P+ + + P+ E K
Sbjct: 46 PAQPISVTMVAPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKPKP 105

Query: 167 KAVEKTPEPNRDTPKPIQPPLAAAAPV 193
K V+K +P RD P +
Sbjct: 106 KPVKKVEQPKRDVKPVESRPASPFENT 132



Score = 32.3 bits (73), Expect = 0.004
Identities = 19/84 (22%), Positives = 29/84 (34%), Gaps = 6/84 (7%)

Query: 139 PSPDQQKD---QTPDKTPEK---SADKAPEKGPEKAVEKTPEPNRDTPKPIQPPLAAAAP 192
P+P Q P P PE E PEP ++ P I+ P P
Sbjct: 44 PAPAQPISVTMVAPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKP 103

Query: 193 VFAPWRESDKDLSKLKPSSRSSAA 216
P ++ ++ +KP A+
Sbjct: 104 KPKPVKKVEQPKRDVKPVESRPAS 127



Score = 30.3 bits (68), Expect = 0.017
Identities = 13/87 (14%), Positives = 25/87 (28%), Gaps = 4/87 (4%)

Query: 108 TKQPNSSDQSTPSPKDQSSQKE-SQNKDGRPTPSPDQQKDQTPDKTPEKSADKAPEKGPE 166
+ + P + + + +P P P + + P+ PE +
Sbjct: 38 HQVIELPAPAQPISVTMVAPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKP 97

Query: 167 KAVEKTPEPNRDTPKPIQPPLAAAAPV 193
K K K ++ P PV
Sbjct: 98 KPKPKPKPK---PVKKVEQPKRDVKPV 121


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1815MECHCHANNEL320.002 Bacterial mechano-sensitive ion channel signature.
		>MECHCHANNEL#Bacterial mechano-sensitive ion channel signature.

Length = 136

Score = 32.1 bits (73), Expect = 0.002
Identities = 14/62 (22%), Positives = 28/62 (45%), Gaps = 8/62 (12%)

Query: 10 VINGLIIVVVTSILLVLYFAMPIYYTKVKDKEVKREFDQTSKQIKGKTVTEIRDILTKKI 69
V + LI+ ++ A+ + + KE +K+ +TEIRD+L ++
Sbjct: 82 VFDFLIVA------FAIFMAIKLINKLNRKKEEPAAAPAPTKEEV--LLTEIRDLLKEQN 133

Query: 70 NK 71
N+
Sbjct: 134 NR 135


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1816HTHFIS831e-20 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 83.0 bits (205), Expect = 1e-20
Identities = 31/128 (24%), Positives = 55/128 (42%), Gaps = 1/128 (0%)

Query: 3 KILVVEDDDTISQVICEFLKANNYDPDCVFDGQAALDKWQTTSYDLIILDIMLPSLSGLE 62
ILV +DD I V+ + L YD + DL++ D+++P + +
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64

Query: 63 VLKTIRKT-SDVPIIMLTALDDEYTQLVSFNHLISDYVTKPFSPLILIKRIENVLRVSTP 121
+L I+K D+P+++++A + T + + DY+ KPF LI I L
Sbjct: 65 LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKR 124

Query: 122 DEKRQIGD 129
+ D
Sbjct: 125 RPSKLEDD 132


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1819RTXTOXIND544e-10 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 54.4 bits (131), Expect = 4e-10
Identities = 34/144 (23%), Positives = 55/144 (38%), Gaps = 10/144 (6%)

Query: 60 DISLTLAGEVTANNSSKVKIDSSKGEVKDVFVKKGDVVKVGQPLFSYETSQRLTAQSSEF 119
+I T G++T + SK VK++ VK+G+ V+ G L +LTA +E
Sbjct: 81 EIVATANGKLTHSGRSKEIKPIENSIVKEIIVKEGESVRKGDVLL------KLTALGAEA 134

Query: 120 DVQTKANQLQVAKTNAALKWETYNRKVNEINTLKSRYNTAPDESLLEQIRSAEDSVSQAL 179
D + Q + A L+ Y I K PDE + + E +L
Sbjct: 135 DTL----KTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSL 190

Query: 180 SDAKTADSDVKTAQIELDKANATA 203
+ + + Q EL+ A
Sbjct: 191 IKEQFSTWQNQKYQKELNLDKKRA 214



Score = 39.4 bits (92), Expect = 2e-05
Identities = 28/180 (15%), Positives = 61/180 (33%), Gaps = 16/180 (8%)

Query: 120 DVQTKANQLQVAKTNAALKWETYNRKVNEINTLKSRYNTAPDESL---LEQIRSAEDSVS 176
D + ++ +AK + Y VNE+ KS+ E L E + +
Sbjct: 239 DFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKN 298

Query: 177 QALSDAKTADSDVKTAQIELDKANATATTEKGKLEYDTVKSDTAGTIVSLNTDLPNQSKS 236
+ L + ++ +EL K + + +++ + + L
Sbjct: 299 EILDKLRQTTDNIGLLTLELAKNEE-------RQQASVIRAPVSVKVQQLKVHTEGGVV- 350

Query: 237 KKENETFMEII-DKSKMLVKGNISEFDRDKLKIGQKVEV-IDRKDNSK--KWTGKVTQVG 292
ET M I+ + + V + D + +GQ + ++ ++ GKV +
Sbjct: 351 -TTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNIN 409


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1822IGASERPTASE465e-07 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 45.8 bits (108), Expect = 5e-07
Identities = 62/330 (18%), Positives = 108/330 (32%), Gaps = 49/330 (14%)

Query: 290 KVVLSEEAPNLRTAKEKVKTLKGI--LHDYYVE-------TNDLEKAKEYHVEDETSPSQ 340
V L +L K K++ + G L++ VE T ++ + + PS
Sbjct: 954 NVSLVGNTVDLGAWKYKLRNVNGRYDLYNPEVEKRNQTVDTTNITTPNNIQADVPSVPSN 1013

Query: 341 PEAPAKP-EAPSPSPAPGQKPAEDERSSQATEPANPSKEDSSTDASQGSHDSENPATDSP 399
E A+ EAP P PAP E ++ ++ + + E + DA++ + +
Sbjct: 1014 NEEIARVDEAPVPPPAPATPSETTETVAENSKQESKTVEKNEQDATETTAQNR------- 1066

Query: 400 SQPQAPDQGNHQSQVPNDKPQTDKTDTPNVPAPPQDTPKVPEAGGQSGPAGNAEEKAPDS 459
+ K NV A Q T +V ++G ++ E K +
Sbjct: 1067 --------------------EVAKEAKSNVKANTQ-TNEVAQSGSETKETQTTETKETAT 1105

Query: 460 GPKESDQ----SSSKESPSVGEDTTPNQPDVLVGGQSEPIDITEDTITDAPPTVSGHNAS 515
KE ++E P V +P Q QSE + + + PTV+
Sbjct: 1106 VEKEEKAKVETEKTQEVPKVTSQVSPKQE------QSETVQPQAEPARENDPTVNIKEPQ 1159

Query: 516 TQPQSVVEDTAPQRPDVLVGGQSEPIDITQDTQPGMSGSNDATVINEDTKPKRVFHFDNK 575
+Q + + P + Q T +T + N T+P NK
Sbjct: 1160 SQTNTTADTEQPAKETSSNVEQPVTESTTVNTGNSVV-ENPENTTPATTQPTVNSESSNK 1218

Query: 576 ESQASEKAAEQKLAPHDSHTTPQASDDTAA 605
++ + TT T A
Sbjct: 1219 PKNRHRRSVRSVPHNVEPATTSSNDRSTVA 1248


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1823ICENUCLEATIN350.002 Ice nucleation protein signature.
		>ICENUCLEATIN#Ice nucleation protein signature.

Length = 1258

Score = 34.7 bits (79), Expect = 0.002
Identities = 33/117 (28%), Positives = 48/117 (41%), Gaps = 5/117 (4%)

Query: 33 STSASSTKTSASTNINTNTSTASAGTG---TSGTASTTPSVGTSTGGAAGGEAAVASSGG 89
T T ST T+ S AG G T+G +ST + STG A VA G
Sbjct: 155 PTQTIEIATYGSTLSGTHQSQLIAGYGSTETAGDSSTLIAGYGSTGTAGADSTLVAGYGS 214

Query: 90 SQSS--ESAQASTQPQAQTAVAASASTTASPSSSEEKTPKTVTSSTSSTPAASSSSN 144
+Q++ ES+Q + QT + S T S+ ++ + ST A S+
Sbjct: 215 TQTAGEESSQMAGYGSTQTGMKGSDLTAGYGSTGTAGDDSSLIAGYGSTQTAGEDSS 271



Score = 34.3 bits (78), Expect = 0.003
Identities = 37/148 (25%), Positives = 57/148 (38%), Gaps = 8/148 (5%)

Query: 12 SVGLVSVGTMLIAPTVLGQEVSTSASSTKTSASTNINTNTSTASAGTGTSGTASTTPSVG 71
S G + LIA Q ++ T ST S +AG G++GTA S+
Sbjct: 294 STGTAGADSSLIAGYGSTQTAGEESTQTAGYGSTQTAQKGSDLTAGYGSTGTAGDDSSLI 353

Query: 72 T---STGGAAGGEAAVASSGGSQSSESAQASTQPQAQTAVAASASTT-----ASPSSSEE 123
ST A + A G +Q+++ T T A + S+ ++ ++ EE
Sbjct: 354 AGYGSTQTAGEDSSLTAGYGSTQTAQKGSDLTAGYGSTGTAGADSSLIAGYGSTQTAGEE 413

Query: 124 KTPKTVTSSTSSTPAASSSSNGNQVTGT 151
T ST + S + G TGT
Sbjct: 414 STQTAGYGSTQTAQKGSDLTAGYGSTGT 441



Score = 32.8 bits (74), Expect = 0.009
Identities = 34/138 (24%), Positives = 58/138 (42%), Gaps = 5/138 (3%)

Query: 12 SVGLVSVGTMLIAPTVLGQEVSTSASSTKTSASTNINTNTSTASAGTGTSGTASTTPSV- 70
S G + LIA Q ++ T ST S +AG G++GTA S+
Sbjct: 390 STGTAGADSSLIAGYGSTQTAGEESTQTAGYGSTQTAQKGSDLTAGYGSTGTAGDDSSLI 449

Query: 71 -GTSTGGAAGGEAAV-ASSGGSQSSESAQASTQPQAQTAVAASASTTASPSSSEEKT--P 126
G + AG ++++ A G +Q+++ T T+ A S+ + S +
Sbjct: 450 AGYGSTQTAGEDSSLTAGYGSTQTAQKGSDLTAGYGSTSTAGYESSLIAGYGSTQTAGYG 509

Query: 127 KTVTSSTSSTPAASSSSN 144
T+T+ ST A + S+
Sbjct: 510 STLTAGYGSTQTAQNESD 527



Score = 32.8 bits (74), Expect = 0.009
Identities = 32/138 (23%), Positives = 55/138 (39%), Gaps = 5/138 (3%)

Query: 12 SVGLVSVGTMLIAPTVLGQEVSTSASSTKTSASTNINTNTSTASAGTGTSGTASTTPSV- 70
S + LIA Q S ++ T ST S +AG G++GTA + S+
Sbjct: 534 STSTAGANSSLIAGYGSTQTASYNSVLTAGYGSTQTAREGSDLTAGYGSTGTAGSDSSII 593

Query: 71 -GTSTGGAAGGEAAV-ASSGGSQSSESAQASTQPQAQTAVAASASTTASPSSSEEKT--P 126
G + A +++ A G +Q++ T T+ A + S+ + S +
Sbjct: 594 AGYGSTQTASYHSSLTAGYGSTQTAREQSVLTTGYGSTSTAGADSSLIAGYGSTQTAGYN 653

Query: 127 KTVTSSTSSTPAASSSSN 144
+T+ ST A S+
Sbjct: 654 SILTAGYGSTQTAQEGSD 671



Score = 32.4 bits (73), Expect = 0.011
Identities = 37/148 (25%), Positives = 56/148 (37%), Gaps = 8/148 (5%)

Query: 12 SVGLVSVGTMLIAPTVLGQEVSTSASSTKTSASTNINTNTSTASAGTGTSGTASTTPSVG 71
S G + LIA Q +S T ST S +AG G++ TA S+
Sbjct: 438 STGTAGDDSSLIAGYGSTQTAGEDSSLTAGYGSTQTAQKGSDLTAGYGSTSTAGYESSLI 497

Query: 72 T---STGGAAGGEAAVASSGGSQSSESAQASTQPQAQTAVAASASTTASPSSSEEKTP-- 126
ST A G A G +Q++++ T+ A + S+ + S +
Sbjct: 498 AGYGSTQTAGYGSTLTAGYGSTQTAQNESDLITGYGSTSTAGANSSLIAGYGSTQTASYN 557

Query: 127 KTVTSSTSSTPAASSSSN---GNQVTGT 151
+T+ ST A S+ G TGT
Sbjct: 558 SVLTAGYGSTQTAREGSDLTAGYGSTGT 585



Score = 31.6 bits (71), Expect = 0.017
Identities = 37/148 (25%), Positives = 58/148 (39%), Gaps = 8/148 (5%)

Query: 12 SVGLVSVGTMLIAPTVLGQEVSTSASSTKTSASTNINTNTSTASAGTGTSGTASTTPSV- 70
S G + LIA Q +S T ST S +AG G++GTA S+
Sbjct: 246 STGTAGDDSSLIAGYGSTQTAGEDSSLTAGYGSTQTAQKGSDLTAGYGSTGTAGADSSLI 305

Query: 71 -GTSTGGAAGGEAA-VASSGGSQSSESAQASTQPQAQTAVAASASTT-----ASPSSSEE 123
G + AG E+ A G +Q+++ T T A S+ ++ ++ E+
Sbjct: 306 AGYGSTQTAGEESTQTAGYGSTQTAQKGSDLTAGYGSTGTAGDDSSLIAGYGSTQTAGED 365

Query: 124 KTPKTVTSSTSSTPAASSSSNGNQVTGT 151
+ ST + S + G TGT
Sbjct: 366 SSLTAGYGSTQTAQKGSDLTAGYGSTGT 393



Score = 31.6 bits (71), Expect = 0.020
Identities = 36/148 (24%), Positives = 56/148 (37%), Gaps = 8/148 (5%)

Query: 12 SVGLVSVGTMLIAPTVLGQEVSTSASSTKTSASTNINTNTSTASAGTGTSGTASTTPSVG 71
S G + L+A Q +S ST S +AG G++GTA S+
Sbjct: 198 STGTAGADSTLVAGYGSTQTAGEESSQMAGYGSTQTGMKGSDLTAGYGSTGTAGDDSSLI 257

Query: 72 T---STGGAAGGEAAVASSGGSQSSESAQASTQPQAQTAVAASASTT-----ASPSSSEE 123
ST A + A G +Q+++ T T A + S+ ++ ++ EE
Sbjct: 258 AGYGSTQTAGEDSSLTAGYGSTQTAQKGSDLTAGYGSTGTAGADSSLIAGYGSTQTAGEE 317

Query: 124 KTPKTVTSSTSSTPAASSSSNGNQVTGT 151
T ST + S + G TGT
Sbjct: 318 STQTAGYGSTQTAQKGSDLTAGYGSTGT 345



Score = 31.6 bits (71), Expect = 0.021
Identities = 36/148 (24%), Positives = 57/148 (38%), Gaps = 8/148 (5%)

Query: 12 SVGLVSVGTMLIAPTVLGQEVSTSASSTKTSASTNINTNTSTASAGTGTSGTASTTPSV- 70
S G + LIA Q +S T ST S +AG G++GTA S+
Sbjct: 342 STGTAGDDSSLIAGYGSTQTAGEDSSLTAGYGSTQTAQKGSDLTAGYGSTGTAGADSSLI 401

Query: 71 -GTSTGGAAGGEAA-VASSGGSQSSESAQASTQPQAQTAVAASASTT-----ASPSSSEE 123
G + AG E+ A G +Q+++ T T A S+ ++ ++ E+
Sbjct: 402 AGYGSTQTAGEESTQTAGYGSTQTAQKGSDLTAGYGSTGTAGDDSSLIAGYGSTQTAGED 461

Query: 124 KTPKTVTSSTSSTPAASSSSNGNQVTGT 151
+ ST + S + G T T
Sbjct: 462 SSLTAGYGSTQTAQKGSDLTAGYGSTST 489



Score = 31.3 bits (70), Expect = 0.023
Identities = 35/144 (24%), Positives = 54/144 (37%), Gaps = 7/144 (4%)

Query: 12 SVGLVSVGTMLIAPTVLGQEVSTSASSTKTSASTNINTNTSTASAGTGTSGTASTTPSV- 70
S G + +IA Q S +S T ST S + G G++ TA S+
Sbjct: 582 STGTAGSDSSIIAGYGSTQTASYHSSLTAGYGSTQTAREQSVLTTGYGSTSTAGADSSLI 641

Query: 71 -GTSTGGAAGGEAAVASSGGSQSSESAQASTQPQAQTAVAASASTTASPSSSEEKTPKTV 129
G + AG + + + G S Q + + TA S ST + SS T
Sbjct: 642 AGYGSTQTAGYNSILTAGYG-----STQTAQEGSDLTAGYGSTSTAGADSSLIAGYGSTQ 696

Query: 130 TSSTSSTPAASSSSNGNQVTGTEV 153
T+ +S A S G+++
Sbjct: 697 TAGYNSILTAGYGSTQTAQEGSDL 720



Score = 30.5 bits (68), Expect = 0.041
Identities = 32/138 (23%), Positives = 48/138 (34%), Gaps = 5/138 (3%)

Query: 12 SVGLVSVGTMLIAPTVLGQEVSTSASSTKTSASTNINTNTSTASAGTGTSGTASTTPSVG 71
S + LIA Q ++ T ST N S G G++ TA S+
Sbjct: 486 STSTAGYESSLIAGYGSTQTAGYGSTLTAGYGSTQTAQNESDLITGYGSTSTAGANSSLI 545

Query: 72 T---STGGAAGGEAAVASSGGSQSSESAQASTQPQAQTAVAASASTTASPSSSEEKT--P 126
ST A+ A G +Q++ T T A S S+ + S +
Sbjct: 546 AGYGSTQTASYNSVLTAGYGSTQTAREGSDLTAGYGSTGTAGSDSSIIAGYGSTQTASYH 605

Query: 127 KTVTSSTSSTPAASSSSN 144
++T+ ST A S
Sbjct: 606 SSLTAGYGSTQTAREQSV 623



Score = 30.5 bits (68), Expect = 0.043
Identities = 28/105 (26%), Positives = 42/105 (40%), Gaps = 5/105 (4%)

Query: 44 STNINTNTSTASAGTGTSGTASTTPSVGT---STGGAAGGEAAVASSGGSQ--SSESAQA 98
ST S +AG G++ TA + + ST A + +A G +Q S S+
Sbjct: 694 STQTAGYNSILTAGYGSTQTAQEGSDLTSGYGSTSTAGADSSLIAGYGSTQTASYHSSLT 753

Query: 99 STQPQAQTAVAASASTTASPSSSEEKTPKTVTSSTSSTPAASSSS 143
+ QTA S TT S+S ++ + ST A S
Sbjct: 754 AGYGSTQTAREQSVLTTGYGSTSTAGADSSLIAGYGSTQTAGYHS 798


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy182460KDINNERMP270.006 60kDa inner membrane protein signature.
		>60KDINNERMP#60kDa inner membrane protein signature.

Length = 548

Score = 27.2 bits (60), Expect = 0.006
Identities = 6/24 (25%), Positives = 9/24 (37%)

Query: 22 YSKKVLADEPTSYQPPAAHSPCDD 45
+ + A + T AA S D
Sbjct: 27 KNPQPQAQQTTQTTTTAAGSAADQ 50


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1827STREPTOPAIN596e-14 Streptopain (C10) cysteine protease family signature.
		>STREPTOPAIN#Streptopain (C10) cysteine protease family signature.

Length = 398

Score = 59.3 bits (143), Expect = 6e-14
Identities = 39/102 (38%), Positives = 56/102 (54%), Gaps = 7/102 (6%)

Query: 2 EMHFVRTEPEARRIAETFCAENTQTKTPMRVQQLSYPSDTDHSGGEL-----YIYALSPA 56
+ +F R E EA+ A TF ++ K R + D + GGEL Y+Y +S
Sbjct: 28 DQNFARNEKEAKDSAITFIQKSAAIKAGARSAE-DIKLDKVNLGGELSGSNMYVYNISTG 86

Query: 57 GFIIVSGDTRAHTILGYSFDNNLDLN-HDNVRSMVEAYQKQI 97
GF+IVSGD R+ ILGYS + D N +N+ S +E+Y +QI
Sbjct: 87 GFVIVSGDKRSPEILGYSTSGSFDANGKENIASFMESYVEQI 128


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
MGAS10750_Spy1828STREPTOPAIN7110.0 Streptopain (C10) cysteine protease family signature.
		>STREPTOPAIN#Streptopain (C10) cysteine protease family signature.

Length = 398

Score = 711 bits (1835), Expect = 0.0
Identities = 395/398 (99%), Positives = 396/398 (99%)

Query: 1 MNKKKLGIRLLSLLALGGFVLANPVFADQNFARNEKEAKDSAITFIQKSAAIKAGARSTE 60
MNKKKLG+RLLSLLALGGFVLANPVFADQNFARNEKEAKDSAITFIQKSAAIKAGARS E
Sbjct: 1 MNKKKLGVRLLSLLALGGFVLANPVFADQNFARNEKEAKDSAITFIQKSAAIKAGARSAE 60

Query: 61 DIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASF 120
DIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASF
Sbjct: 61 DIKLDKVNLGGELSGSNMYVYNISTGGFVIVSGDKRSPEILGYSTSGSFDANGKENIASF 120

Query: 121 MESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGE 180
MESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGE
Sbjct: 121 MESYVEQIKENKKLDTTYAGTAEIKQPVVKSLLDSKGIHYNQGNPYNLLTPVIEKVKPGE 180

Query: 181 QSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQY 240
QSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQY
Sbjct: 181 QSFVGQHAATGCVATATAQIMKYHNYPNKGLKDYTYTLSSNNPYFNHPKNLFAAISTRQY 240

Query: 241 NWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQ 300
NWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQ
Sbjct: 241 NWNNILPTYSGRESNVQKMAISELMADVGISVDMDYGPSSGSAGSSRVQRALKENFGYNQ 300

Query: 301 SVHQINRSDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWG 360
SVHQINR DFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWG
Sbjct: 301 SVHQINRGDFSKQDWEAQIDKELSQNQPVYYQGVGKVGGHAFVIDGADGRNFYHVNWGWG 360

Query: 361 GVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP 398
GVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP
Sbjct: 361 GVSDGFFRLDALNPSALGTGGGAGGFNGYQSAVVGIKP 398



 
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