PredictBias

identification of genomic and pathogenicity islands in prokaryotic genome
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A) Input parameters
Genome2253.gbkThreshold dinucleotide bias2
Threshold codon bias4Threshold %GC bias3
E-value (RPSBlast)0.05Genome (non-pathogenic)
 
B) Compare a potential GI or PAI in related non-pathogenic sp. (phylogenetic tree)
Potential GI or PAI start    end  
Select Organism     
 
C) Potential GIs and PAIs in NC_009901 (download)
S.NoStartEndBiasVirulenceInsertion elementsPrediction
1Spea_0038Spea_0080Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_0038-118-3.187577coproporphyrinogen III oxidase
Spea_0039-121-4.666738globin
Spea_0040-121-4.471587shikimate 5-dehydrogenase
Spea_0041-219-5.544526hypothetical protein
Spea_0042-217-4.885863carbonic anhydrase
Spea_0043-320-5.382847hypothetical protein
Spea_0044-220-3.915565hypothetical protein
Spea_0045-121-3.808931hypothetical protein
Spea_0046-126-4.728541polysaccharide biosynthesis protein CapD
Spea_0047029-4.600611DegT/DnrJ/EryC1/StrS aminotransferase
Spea_0048030-5.594732UDP-N-acetylglucosamine 2-epimerase
Spea_0049028-6.079255N-acylneuraminate-9-phosphate synthase
Spea_0050126-5.449646sialic acid synthase
Spea_0051122-4.729683nucleotidyl transferase
Spea_0052020-3.144528acylneuraminate cytidylyltransferase
Spea_0053020-2.589986hypothetical protein
Spea_0054018-0.734581hypothetical protein
Spea_00551170.048263OmpA/MotB domain-containing protein
Spea_00562160.235156MotA/TolQ/ExbB proton channel
Spea_00573130.485653flagellar biosynthesis sigma factor
Spea_00583170.434168flagellar basal body-associated protein FliL
Spea_00593160.612358flagellar hook-length control protein
Spea_00603170.165559hypothetical protein
Spea_00611150.186430flagellar protein FliS
Spea_00621140.248599flagellar hook-associated 2 domain-containing
Spea_0063-1151.080247flagellin domain-containing protein
Spea_0064-1161.519415hypothetical protein
Spea_0065-1172.258060flagellar hook-associated protein 3
Spea_0066-1163.198643flagellar hook-associated protein FlgK
Spea_00670194.061465peptidoglycan hydrolase
Spea_00681193.946305flagellar basal body P-ring protein
Spea_00690203.792177flagellar basal body L-ring protein
Spea_0070-1183.705652flagellar basal-body rod protein FlgG
Spea_0071-1163.279088flagellar basal-body rod protein FlgF
Spea_00720152.115665flagellar hook protein FlgE
Spea_0073-1141.494571flagellar hook capping protein
Spea_00741171.239886flagellar basal-body rod protein FlgC
Spea_00750182.567186flagellar basal body rod protein FlgB
Spea_00760162.976742SAF domain-containing protein
Spea_00770153.228835hypothetical protein
Spea_0078-1143.262920hypothetical protein
Spea_0079-2153.276855hypothetical protein
Spea_0080-2153.369808FliI/YscN family ATPase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0040BCTERIALGSPF310.003 Bacterial general secretion pathway protein F signa...
		>BCTERIALGSPF#Bacterial general secretion pathway protein F

signature.
Length = 408

Score = 31.3 bits (71), Expect = 0.003
Identities = 17/75 (22%), Positives = 31/75 (41%), Gaps = 9/75 (12%)

Query: 67 EQAFALCDELSEQAKLAGAVNTLSVLADGKIRGDNTDGLGLVADLQRNLGSLTGLKVLLV 126
E+A + SE+ L+ ++A +R +G L ++ GS L +V
Sbjct: 88 EEALDAVAKQSEKPHLS------QLMAA--VRSKVMEGHSLADAMKCFPGSFERLYCAMV 139

Query: 127 GAGGAARGSVLPLLQ 141
AG + G + +L
Sbjct: 140 AAGETS-GHLDAVLN 153


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0046NUCEPIMERASE384e-05 Nucleotide sugar epimerase signature.
		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

Length = 334

Score = 38.2 bits (89), Expect = 4e-05
Identities = 41/210 (19%), Positives = 77/210 (36%), Gaps = 26/210 (12%)

Query: 31 SFLILGGAGSIGQAVTKEIFKRQPKKLHVVDISENNMVELVRDLRSSFGYIDGEFNTYAL 90
+L+ G AG IG V+K + + + + + ++++ V L + F + +
Sbjct: 2 KYLVTGAAGFIGFHVSKRLLEAGHQVVGIDNLNDYYDVSLKQARLELLA--QPGFQFHKI 59

Query: 91 DIGSIEYDAFIKADGHYDYVLNLSALKHVR-SEKDPFTLMRMIDVNI------------F 137
D+ E + A GH++ V VR S ++P D N+
Sbjct: 60 DLADREGMTDLFASGHFERVFISPHRLAVRYSLENPHAY---ADSNLTGFLNILEGCRHN 116

Query: 138 NTDKTVQQAIDS--GAKKYFCVST-DKAANPVNMMGASKRIMEMFLMRKSEHIAISTA-- 192
+ + S G + ST D +PV++ A+K+ E+ S +
Sbjct: 117 KIQHLLYASSSSVYGLNRKMPFSTDDSVDHPVSLYAATKKANELMAHTYSHLYGLPATGL 176

Query: 193 RFANVAFSDGS---LLHGFNQRIQKSQPIV 219
RF V G L F + + + + I
Sbjct: 177 RFFTVYGPWGRPDMALFKFTKAMLEGKSID 206


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0059FLGHOOKFLIK392e-05 Flagellar hook-length control protein signature.
		>FLGHOOKFLIK#Flagellar hook-length control protein signature.

Length = 375

Score = 39.4 bits (91), Expect = 2e-05
Identities = 29/100 (29%), Positives = 49/100 (49%)

Query: 236 ASSTRSQTAVAQWGPVAVSQTAPLLQQAHEMLSPLREQLKFQIDQQIKQAEIRLDPPELG 295
A+S Q P + +HE L + + Q + AE+RL P +LG
Sbjct: 210 AASPLITPHQTQPLPTVAAPVLSAPLGSHEWQQSLSQHISLFTRQGQQSAELRLHPQDLG 269

Query: 296 KVELNVRLDGDRLHIQMHAANSSVRDALLMGLDRLRAELA 335
+V++++++D ++ IQM + + VR AL L LR +LA
Sbjct: 270 EVQISLKVDDNQAQIQMVSPHQHVRAALEAALPVLRTQLA 309


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0063FLAGELLIN1072e-28 Flagellin signature.
		>FLAGELLIN#Flagellin signature.

Length = 507

Score = 107 bits (267), Expect = 2e-28
Identities = 76/269 (28%), Positives = 123/269 (45%), Gaps = 8/269 (2%)

Query: 4 VMTNNASNIAQNSVNRNNDLLSNAMERLSTGLRINSAADDAAGLQIASRMEANVTGMETA 63
+ TN+ S + QN++N++ LS+A+ERLS+GLRINSA DDAAG IA+R +N+ G+ A
Sbjct: 4 INTNSLSLLTQNNLNKSQSSLSSAIERLSSGLRINSAKDDAAGQAIANRFTSNIKGLTQA 63

Query: 64 NRNVSDATSMLQTADGALDELATIANRQKELATQAANGVNSTADRAALNDEFTALTAEMT 123
+RN +D S+ QT +GAL+E+ R +EL+ QA NG NS +D ++ DE E+
Sbjct: 64 SRNANDGISIAQTTEGALNEINNNLQRVRELSVQATNGTNSDSDLKSIQDEIQQRLEEID 123

Query: 124 RIMEKTTYAGNDLFGAISGNVSFQIGAGSGETLTV------SGASGITGIRSGIATLSGV 177
R+ +T + G + + Q+GA GET+T+ + G+ G + V
Sbjct: 124 RVSNQTQFNGVKVLSQ-DNQMKIQVGANDGETITIDLQKIDVKSLGLDGFNVNGPKEATV 182

Query: 178 KASTL-GAQIGEIDDFIDAVGSMRSDLGANINRLGHTASNLTNVTENTKAAAGRIMDADF 236
+ D + R D+ + TA + + A D
Sbjct: 183 GDLKSSFKNVTGYDTYAVGANKYRVDVNSGAVVTDTTAPTVPDKVYVNAANGQLTTDDAE 242

Query: 237 ASETAAMSKNQLLVQAGTNILSSSNQNTG 265
+ + K + + G
Sbjct: 243 NNTAVDLFKTTKSTAGTAEAKAIAGAIKG 271



Score = 64.7 bits (157), Expect = 6e-14
Identities = 43/204 (21%), Positives = 74/204 (36%)

Query: 68 SDATSMLQTADGALDELATIANRQKELATQAANGVNSTADRAALNDEFTALTAEMTRIME 127
+ + T A + + + V + + +
Sbjct: 303 INGEKVTLTVADITAGAANVDAATLQSSKNVYTSVVNGQFTFDDKTKNESAKLSDLEANN 362

Query: 128 KTTYAGNDLFGAISGNVSFQIGAGSGETLTVSGASGITGIRSGIATLSGVKASTLGAQIG 187
+ + T+ +G+ + I + + +
Sbjct: 363 AVKGESKITVNGAEYTANAAGDKVTLAGKTMFIDKTASGVSTLINEDAAAAKKSTANPLA 422

Query: 188 EIDDFIDAVGSMRSDLGANINRLGHTASNLTNVTENTKAAAGRIMDADFASETAAMSKNQ 247
ID + V ++RS LGA NR +NL N N +A RI DAD+A+E + MSK Q
Sbjct: 423 SIDSALSKVDAVRSSLGAIQNRFDSAITNLGNTVTNLNSARSRIEDADYATEVSNMSKAQ 482

Query: 248 LLVQAGTNILSSSNQNTGLVMGLL 271
+L QAGT++L+ +NQ V+ LL
Sbjct: 483 ILQQAGTSVLAQANQVPQNVLSLL 506


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0064FbpA_PF05833371e-04 Fibronectin-binding protein
		>FbpA_PF05833#Fibronectin-binding protein

Length = 577

Score = 36.8 bits (85), Expect = 1e-04
Identities = 32/270 (11%), Positives = 95/270 (35%), Gaps = 17/270 (6%)

Query: 40 PTHRLESYNKWAKVTQGQHRISAAQVAEQGLQQVQQ---------LLKQLQSQVKQSLAS 90
+ +L ++ + + + ++ Q+ + ++ + +L++ S
Sbjct: 167 KSPKLNPFDFSYDMIENFTKENSLQLNDNIFSKIFTGVSKTLSSEICFRLKNNSIDLSLS 226

Query: 91 SASEQSMLEQTARSKLIQNKLSQLAISYDNKPLIDHQLNLISAKRPAAQHSFSLKSVDLT 150
+ E + + ++ NK + +N + + LNL+S + S +
Sbjct: 227 NLKEIVEVCKDLFKEIQSNKFEFNCYTKNNSFVGFYCLNLMSKEDYKKIQYDSSSKLLEN 286

Query: 151 ASKQRDERLII-QVGNQSTSLVLPANKQPQQLLTKINDSLKALEIKANHSKEGKLIFTSP 209
+D+ + + +V+ + + +N++LK E K G+L+ +
Sbjct: 287 FYYAKDKSDRLKSKSSDLQKIVMNNINRCTKKDKILNNTLKKCEDKDIFKLYGELLTAN- 345

Query: 210 KSQWQQIQTGILMTGQGQRLPAGEPRTIKVNEELSWQDPREWRFGSNAELKQAIAKIAKS 269
++ + I + + I ++E + + + +LK++ +
Sbjct: 346 IYALKKGLSHIELANYYS--ENYDTVKITLDENKTPSQNVQSYYKKYNKLKKSEEAANEQ 403

Query: 270 LHKVEQQLQELSDSKQKILQQLQQLSLKKD 299
L + E++L L +L + +
Sbjct: 404 LLQNEEELNYL----YSVLTNINNADNYDE 429


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0065FLAGELLIN492e-08 Flagellin signature.
		>FLAGELLIN#Flagellin signature.

Length = 507

Score = 48.5 bits (115), Expect = 2e-08
Identities = 33/201 (16%), Positives = 66/201 (32%), Gaps = 5/201 (2%)

Query: 1 MRVSMHNLYANNLQSLQNSTVDIARLNEMMATGSSILRPSDDPIGAVKVMGNERDMAATE 60
++ ++L +L S ++ E +++G I DD G ++
Sbjct: 2 QVINTNSLSLLTQNNLNKSQSSLSSAIERLSSGLRINSAKDDAAGQAIANRFTSNIKGLT 61

Query: 61 QYLKNTESLSSSFGRAETYMSSMVELQNRMREITVSASNGSLSAEDRTAYAAELEELLES 120
Q +N S E ++ + R+RE++V A+NG+ S D + E+++ LE
Sbjct: 62 QASRNANDGISIAQTTEGALNEINNNLQRVRELSVQATNGTNSDSDLKSIQDEIQQRLEE 121

Query: 121 FSDVLNAKDEGGNYLFSGNETDTPPIGKDAAGNYVYQGDTSHREVQTSSSSWMTANSTAA 180
V N G + S + +G + S + +
Sbjct: 122 IDRVSNQTQFNGVKVLSQDNQMKIQVGANDGETITIDLQKI-----DVKSLGLDGFNVNG 176

Query: 181 DFIFSNGSADILNQTKDFIDA 201
+ G + D
Sbjct: 177 PKEATVGDLKSSFKNVTGYDT 197


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0066FLGHOOKAP11672e-48 Flagellar hook-associated protein signature.
		>FLGHOOKAP1#Flagellar hook-associated protein signature.

Length = 546

Score = 167 bits (425), Expect = 2e-48
Identities = 95/320 (29%), Positives = 158/320 (49%), Gaps = 8/320 (2%)

Query: 2 SMLNIGMSGLNASMAALTATSNNVSNAMVPGYSRQQVVMSSVGNGTYGS---GSGVMVDG 58
S++N MSGLNA+ AAL SNN+S+ V GY+RQ +M+ + G+GV V G
Sbjct: 2 SLINNAMSGLNAAQAALNTASNNISSYNVAGYTRQTTIMAQANSTLGAGGWVGNGVYVSG 61

Query: 59 VRRISDQYQVTQQWNATSNLGFAETQASYFGQVEQIFGSEGNSISAGLDLLFASLNSAME 118
V+R D + Q A + + +++ + + +S++ + F SL + +
Sbjct: 62 VQREYDAFITNQLRAAQTQSSGLTARYEQMSKIDNMLSTSTSSLATQMQDFFTSLQTLVS 121

Query: 119 QPNEIALRQGVLNEAKALTQRFNSISEGVHTQVNQIEGQIGASAKEINAQLETISSFNEQ 178
+ A RQ ++ +++ L +F + + + Q Q+ IGAS +IN + I+S N+Q
Sbjct: 122 NAEDPAARQALIGKSEGLVNQFKTTDQYLRDQDKQVNIAIGASVDQINNYAKQIASLNDQ 181

Query: 179 IQAS--NASGNVPLSLLDARDAAIDDLSKIIDVNIVHDANNMVNISLVQGQPLLSGTTAS 236
I +G P +LLD RD + +L++I+ V + NI++ G L+ G+TA
Sbjct: 182 ISRLTGVGAGASPNNLLDQRDQLVSELNQIVGVEVSVQDGGTYNITMANGYSLVQGSTAR 241

Query: 237 KIQV---SPDPSNPLFSQLSVQFGQSSFPLDESAGGSLGALLDYRDNSLVESIAFNNELA 293
++ S DPS + + G P GSLG +L +R L ++ +LA
Sbjct: 242 QLAAVPSSADPSRTTVAYVDGTAGNIEIPEKLLNTGSLGGILTFRSQDLDQTRNTLGQLA 301

Query: 294 QTMADEFNTILKAGTDLNGN 313
A+ FNT KAG D NG+
Sbjct: 302 LAFAEAFNTQHKAGFDANGD 321



Score = 69.2 bits (169), Expect = 9e-15
Identities = 39/110 (35%), Positives = 63/110 (57%), Gaps = 3/110 (2%)

Query: 346 QDGTPGDNSNLKALVELADKSFTFDSMGIDATMGDAFASKIGELGSASRQAKMAKETAEK 405
+D DN N +AL++L S ++G + DA+AS + ++G+ + K + T
Sbjct: 438 EDAGDSDNRNGQALLDLQSNS---KTVGGAKSFNDAYASLVSDIGNKTATLKTSSATQGN 494

Query: 406 VQIEAQSQWASTSGVNMDEEGVNLIIYQQSYQANAKVISTADQLFQTILN 455
V + +Q S SGVN+DEE NL +QQ Y ANA+V+ TA+ +F ++N
Sbjct: 495 VVTQLSNQQQSISGVNLDEEYGNLQRFQQYYLANAQVLQTANAIFDALIN 544


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0067FLGFLGJ491e-09 Flagellar protein FlgJ signature.
		>FLGFLGJ#Flagellar protein FlgJ signature.

Length = 313

Score = 48.6 bits (115), Expect = 1e-09
Identities = 29/124 (23%), Positives = 56/124 (45%), Gaps = 16/124 (12%)

Query: 26 GALKLVSQQFEAQFLQTVLKQMRSASDVMADEDSPLSSQNDGMYRDWHDAELAGRLSQMQ 85
++ V++Q E F+Q +LK MR A +D SS++ +Y +D ++A +++ +
Sbjct: 31 ANIRPVARQVEGMFVQMMLKSMRDALP----KDGLFSSEHTRLYTSMYDQQIAQQMTAGK 86

Query: 86 STGLASVMTKQLSSA------------LKSSPETVASNQHETVNVANPNTRAMQPALIVP 133
GLA +M KQ++ +K ETV Q++ ++ +P
Sbjct: 87 GLGLAEMMVKQMTPEQPLPEESTPAAPMKFPLETVVRYQNQALSQLVQKAVPRNYDDSLP 146

Query: 134 FIAK 137
+K
Sbjct: 147 GDSK 150


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0068FLGPRINGFLGI343e-119 Flagellar P-ring protein signature.
		>FLGPRINGFLGI#Flagellar P-ring protein signature.

Length = 373

Score = 343 bits (882), Expect = e-119
Identities = 151/381 (39%), Positives = 219/381 (57%), Gaps = 15/381 (3%)

Query: 1 MKKIALFITSMLLALLPLL-PVQAEIQNRYLMDIVDVQGIRDNQLVGYGLVVGLDGTGDK 59
M+ + + +++ + LP L A+ + DI +Q RDNQL+GYGLVVGL GTGD
Sbjct: 1 MRVLRIIAAALVFSALPFLSTPPAQADTSRIKDIASLQAGRDNQLIGYGLVVGLQGTGDS 60

Query: 60 -NQVKFTSQSVVNMLKQFGVQIDDKTDPKLKNVAAVAVSATVPPLASPGQTLDITVSSLG 118
FT QS+ ML+ G+ KN+AAV V+A +PP ASPG +D+TVSSLG
Sbjct: 61 LRSSPFTEQSMRAMLQNLGITTQG-GQSNAKNIAAVMVTANLPPFASPGSRVDVTVSSLG 119

Query: 119 DAKSLRGGTLLMTPLRAVDGEIYAVAQGNLVVGGVSAQGRNGSSITVNIPTVGNIPNGAL 178
DA SLRGG L+MT L DG+IYAVAQG L+V G SAQG + +++T + T +PNGA+
Sbjct: 120 DATSLRGGNLIMTSLSGADGQIYAVAQGALIVNGFSAQG-DAATLTQGVTTSARVPNGAI 178

Query: 179 LEAAMKSNFNETEHIVLNLKQPSFKTARNIERAVNEL----FGPSVAEADSNAKVMVRAP 234
+E + S F ++ ++VL L+ P F TA + VN +G +AE + ++ V+ P
Sbjct: 179 IERELPSKFKDSVNLVLQLRNPDFSTAVRVADVVNAFARARYGDPIAEPRDSQEIAVQKP 238

Query: 235 SSNRERVTFMSMLEELQIEQGRKSPRVVFNSRTGTVVMGGDVVVRKAAVSHGNLTVSIVE 294
+ M+ +E L +E +VV N RTGT+V+G DV + + AVS+G LTV + E
Sbjct: 239 -RVADLTRLMAEIENLTVETDTP-AKVVINERTGTIVIGADVRISRVAVSYGTLTVQVTE 296

Query: 295 QQNVSQPNGAFLGQAQGETVVTNDSTVDIEQGNGHMFVWEEGVALDDIVRAVNSLGASPM 354
V QP F G+T V + + Q + + EG L +V +NS+G
Sbjct: 297 SPQVIQPA-PFSR---GQTAVQPQTDIMAMQEGSKVAI-VEGPDLRTLVAGLNSIGLKAD 351

Query: 355 DLMSILQALDEAGALEAELVV 375
+++ILQ + AGAL+AELV+
Sbjct: 352 GIIAILQGIKSAGALQAELVL 372


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0069FLGLRINGFLGH1445e-45 Flagellar L-ring protein signature.
		>FLGLRINGFLGH#Flagellar L-ring protein signature.

Length = 232

Score = 144 bits (364), Expect = 5e-45
Identities = 72/223 (32%), Positives = 112/223 (50%), Gaps = 15/223 (6%)

Query: 12 LVLLLSGCISHIPELDTKPGKPEWAPPEIDYSLPDAKDGSVYRPGFMLT-----LFKDKR 66
LVL L+GC + IP + P + +GS+++ + LF+D+R
Sbjct: 15 LVLSLTGC-AWIP---STPLVQGATSAQPVPGPTPVANGSIFQSAQPINYGYQPLFEDRR 70

Query: 67 AFREGDILTVALDEKTYSSKSADTKTNK--NTGLSLDGQGTTGNNSIAGSG---EANLGS 121
GD LT+ L E +SKS+ ++ T D + EA+ G+
Sbjct: 71 PRNIGDTLTIVLQENVSASKSSSANASRDGKTNFGFDTVPRYLQGLFGNARADVEASGGN 130

Query: 122 SFSGTGSSTQQNQLSGSITVTVAKVLPNGALLIRGEKWLRLNQGDEYLRLLGLIRTDDIG 181
+F+G G + N SG++TVTV +VL NG L + GEK + +NQG E++R G++ I
Sbjct: 131 TFNGKGGANASNTFSGTLTVTVDQVLVNGNLHVVGEKQIAINQGTEFIRFSGVVNPRTIS 190

Query: 182 NDNTISSQRIADARIIYGGQGAITDSNRMGWASRYFNSPWFPL 224
NT+ S ++ADARI Y G G I ++ MGW R+F + P+
Sbjct: 191 GSNTVPSTQVADARIEYVGNGYINEAQNMGWLQRFFLN-LSPM 232


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0070FLGHOOKAP1412e-06 Flagellar hook-associated protein signature.
		>FLGHOOKAP1#Flagellar hook-associated protein signature.

Length = 546

Score = 41.5 bits (97), Expect = 2e-06
Identities = 11/47 (23%), Positives = 21/47 (44%)

Query: 213 QVRQGALEGANVNVVEEMVEMISTQRAYEMNAKVVSASDDMLKFLNQ 259
Q+ + VN+ EE + Q+ Y NA+V+ ++ + L
Sbjct: 498 QLSNQQQSISGVNLDEEYGNLQRFQQYYLANAQVLQTANAIFDALIN 544



Score = 40.7 bits (95), Expect = 4e-06
Identities = 22/89 (24%), Positives = 36/89 (40%), Gaps = 17/89 (19%)

Query: 3 SALWVSKTGLTAQDTKMTTIANNLANVNTTGFKRDRVAFNDLFYQVQRQPGGQVDEQNQL 62
S + + +GL A + T +NN+++ N G+ R + L
Sbjct: 2 SLINNAMSGLNAAQAALNTASNNISSYNVAGYTRQTTI--------------MAQANSTL 47

Query: 63 PAGLQLGTGTRVAGTQKVFTPGDMLTTNQ 91
AG +G G V+G Q+ + D TNQ
Sbjct: 48 GAGGWVGNGVYVSGVQREY---DAFITNQ 73


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0072FLGHOOKAP1340.001 Flagellar hook-associated protein signature.
		>FLGHOOKAP1#Flagellar hook-associated protein signature.

Length = 546

Score = 33.8 bits (77), Expect = 0.001
Identities = 15/41 (36%), Positives = 22/41 (53%)

Query: 360 LEGSNVDQTAEMVNLMTAQRNYQSNAKVLDTNSTMQQALLN 400
S V+ E NL Q+ Y +NA+VL T + + AL+N
Sbjct: 504 QSISGVNLDEEYGNLQRFQQYYLANAQVLQTANAIFDALIN 544



Score = 33.0 bits (75), Expect = 0.002
Identities = 21/57 (36%), Positives = 27/57 (47%), Gaps = 5/57 (8%)

Query: 2 SFNIALSGLQATTQDLNTISNNIANSSTVGFRSGR----SEFSAIYNGGQAG-GVNV 53
N A+SGL A LNT SNNI++ + G+ S + GG G GV V
Sbjct: 3 LINNAMSGLNAAQAALNTASNNISSYNVAGYTRQTTIMAQANSTLGAGGWVGNGVYV 59


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0074FLGHOOKAP1334e-04 Flagellar hook-associated protein signature.
		>FLGHOOKAP1#Flagellar hook-associated protein signature.

Length = 546

Score = 32.6 bits (74), Expect = 4e-04
Identities = 8/39 (20%), Positives = 19/39 (48%)

Query: 98 SNVNTVEEMADMMAASRSFETSVEVMNRARSMQQGLLQL 136
S VN EE ++ + + + +V+ A ++ L+ +
Sbjct: 507 SGVNLDEEYGNLQRFQQYYLANAQVLQTANAIFDALINI 545



Score = 26.5 bits (58), Expect = 0.048
Identities = 14/59 (23%), Positives = 25/59 (42%), Gaps = 4/59 (6%)

Query: 9 IAGAGMNAQTIRLNTVASNLANAGAAAESPDQAFRALKPVFSTIYKQTQEGELAGAHVE 67
A +G+NA LNT ++N+++ A + + ST+ G G +V
Sbjct: 6 NAMSGLNAAQAALNTASNNISSYNVAGYTRQTTI--MAQANSTLGAGGWVGN--GVYVS 60


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_00772FE2SRDCTASE260.024 Ferric iron reductase signature.
		>2FE2SRDCTASE#Ferric iron reductase signature.

Length = 262

Score = 25.8 bits (56), Expect = 0.024
Identities = 11/37 (29%), Positives = 18/37 (48%)

Query: 39 AEVSDDCKLIAHNQPQLEQLADVDLDKVAQIRQSLID 75
A + +D H QPQ LA +A+ R+ L++
Sbjct: 6 APLYEDVIWRTHLQPQDPTLAQAVRATIAKHREHLLE 42


2Spea_0267Spea_0296Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_02672200.425294glutathione-dependent formaldehyde-activating
Spea_0268316-0.410608hypothetical protein
Spea_0269316-0.777140S-(hydroxymethyl)glutathione dehydrogenase
Spea_0270314-1.320903S-formylglutathione hydrolase
Spea_0271118-1.476030small multidrug resistance protein
Spea_0272118-0.824311hypothetical protein
Spea_0273119-0.877472hypothetical protein
Spea_02742150.629253hypothetical protein
Spea_02752150.875657hypothetical protein
Spea_02762140.895567hypothetical protein
Spea_02772161.327389hypothetical protein
Spea_02781161.571855hypothetical protein
Spea_0279-1162.563587hypothetical protein
Spea_02800212.034936hypothetical protein
Spea_0281-118-0.614458lipid A biosynthesis lauroyl (or palmitoleoyl)
Spea_0282017-0.841347hypothetical protein
Spea_0283016-1.168389hypothetical protein
Spea_0284016-1.675909peptidase S9 prolyl oligopeptidase
Spea_0285118-3.602723hypothetical protein
Spea_0286020-3.794916histidine kinase
Spea_0287018-2.579058hypothetical protein
Spea_0288017-1.778625hypothetical protein
Spea_0289221-0.900449hypothetical protein
Spea_0290020-0.472657hypothetical protein
Spea_0291021-0.052416hypothetical protein
Spea_0292020-0.113223hypothetical protein
Spea_0293018-0.206751hypothetical protein
Spea_0294119-0.422354hypothetical protein
Spea_0295119-0.903690hypothetical protein
Spea_0296219-1.220970hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0280ACRIFLAVINRP270.022 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 26.7 bits (59), Expect = 0.022
Identities = 7/21 (33%), Positives = 11/21 (52%)

Query: 58 VIFGALAYFISPIDAIPDLTP 78
++ GALA P+ P + P
Sbjct: 20 MMAGALAILQLPVAQYPTIAP 40


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0286HTHFIS641e-12 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 64.1 bits (156), Expect = 1e-12
Identities = 28/108 (25%), Positives = 56/108 (51%), Gaps = 8/108 (7%)

Query: 762 ILIVEDNLVNQKVASLLVKQAGFDFIIANNGQEAYDFISAGEAFHAILMDCMMPVMDGFT 821
IL+ +D+ + V + + +AG+D I +N + +I+AG+ ++ D +MP + F
Sbjct: 6 ILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGD-GDLVVTDVVMPDENAFD 64

Query: 822 ATEKIREWESQNSQQRLPIIALTA-SVLDQDIEKCYQSGMDDYLAKPF 868
+I++ + LP++ ++A + I+ + G DYL KPF
Sbjct: 65 LLPRIKKA-----RPDLPVLVMSAQNTFMTAIKA-SEKGAYDYLPKPF 106


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0294IGASERPTASE330.002 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 32.7 bits (74), Expect = 0.002
Identities = 28/135 (20%), Positives = 45/135 (33%), Gaps = 22/135 (16%)

Query: 169 SPKLGLSRHQQAPVTLAPTINPTPLSAESSGLEQGQKKLSGIQTNVSQTPSFTPTPITKT 228
SPK S Q A +PT E + + +T S P+T++
Sbjct: 1130 SPKQEQSETVQPQAEPARENDPTVNIKEPQSQTNTT---ADTEQPAKETSSNVEQPVTES 1186

Query: 229 STVPKTAKTIDSPEANIAAAQQAVVQPKIPADNPMAKGNLATGQNPRVRVRVSAKQKRQI 288
+TV +++PE A Q V N + P+ R R R +
Sbjct: 1187 TTVNTGNSVVENPENTTPATTQPTV-------------NSESSNKPKNRHR------RSV 1227

Query: 289 QPVPTTPTEAPVNKS 303
+ VP A + +
Sbjct: 1228 RSVPHNVEPATTSSN 1242


3Spea_0342Spea_0350Y        NNGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_03420163.661677LysR family transcriptional regulator
Spea_03430174.649369DNA-binding transcriptional regulator IlvY
Spea_03440184.476291ketol-acid reductoisomerase
Spea_03450164.868129acetolactate synthase 2 catalytic subunit
Spea_0346-1184.899052amino acid-binding ACT domain-containing
Spea_0347-1194.697097branched-chain amino acid aminotransferase
Spea_0348-1204.605575dihydroxy-acid dehydratase
Spea_0349-1204.126002threonine dehydratase
Spea_03500193.404899serine--pyruvate transaminase
4Spea_0363Spea_0381Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_03634190.285984hypothetical protein
Spea_03644180.459133OmpA/MotB domain-containing protein
Spea_03654180.440214TolC family type I secretion outer membrane
Spea_03663180.345379HlyD family type I secretion membrane fusion
Spea_03673180.352072ABC transporter-like protein
Spea_03684200.275105cadherin
Spea_03690100.558476outer membrane adhesin-like protein
Spea_03703110.340004HemY domain-containing protein
Spea_03712110.516917hypothetical protein
Spea_03721141.359561uroporphyrinogen III synthase HEM4
Spea_03731161.804625porphobilinogen deaminase
Spea_03742221.532364adenylate cyclase
Spea_03752212.060664frataxin family protein
Spea_03762222.304795hypothetical protein
Spea_03772201.748359diaminopimelate decarboxylase
Spea_03782190.950354diaminopimelate epimerase
Spea_03792160.133183hypothetical protein
Spea_03801140.924597tyrosine recombinase XerC
Spea_03812121.457294HAD family hydrolase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0364OMPADOMAIN761e-18 OMPA domain signature.
		>OMPADOMAIN#OMPA domain signature.

Length = 346

Score = 76.1 bits (187), Expect = 1e-18
Identities = 29/119 (24%), Positives = 52/119 (43%), Gaps = 14/119 (11%)

Query: 76 KILFANDSYYIDPQYYPQVEVIASFMQKF--PNTQAVIEGHCSKTGSHQHNQVLSQNRAN 133
+LF + + P+ ++ + S + + V+ G+ + GS +NQ LS+ RA
Sbjct: 220 DVLFNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGLSERRAQ 279

Query: 134 AVSSLLAERFGIDSGRLSAVGYSFDRPIDPTHTASAHK----------INRRVIAELTG 182
+V L + GI + ++SA G P+ +T K +RRV E+ G
Sbjct: 280 SVVDYLISK-GIPADKISARGMGESNPV-TGNTCDNVKQRAALIDCLAPDRRVEIEVKG 336


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0366RTXTOXIND2994e-99 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 299 bits (767), Expect = 4e-99
Identities = 93/441 (21%), Positives = 200/441 (45%), Gaps = 11/441 (2%)

Query: 20 MMTDAPTSHRLIIWALAALAVTFLVWAYFAELDQVTTGMGKVIPSSQVQVIQSLDGGILQ 79
+ T RL+ + + V + + +++ V T GK+ S + + I+ ++ I++
Sbjct: 49 IETPVSRRPRLVAYFIMGFLVIAFILSVLGQVEIVATANGKLTHSGRSKEIKPIENSIVK 108

Query: 80 EMYVQEGLIVTKGQPLVRIDATRFQSDFAQQEQEVNSLVANVVRLQAELNSITISGITND 139
E+ V+EG V KG L+++ A ++D + + + R Q SI ++
Sbjct: 109 EIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNK---- 164

Query: 140 WREQVKISPQPLIFPAALEEGDPKLTNRQREEYTGRLDNLSNQLEIQARQIQQRNQEIQE 199
++K+ +P + E + R + NQ + + ++ E
Sbjct: 165 -LPELKLPDEPY--FQNVSEEEVL---RLTSLIKEQFSTWQNQKYQKELNLDKKRAERLT 218

Query: 200 LASKIRTLTTSFQLVSRELELTRPLAEKGIVPEVELLKLQRVVNDIQGELASLRLLRPKV 259
+ ++I ++ L+ L K + + +L+ + + EL + ++
Sbjct: 219 VLARINRYENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQI 278

Query: 260 KSTMDEAILKRRESVLIYAADSRAQLNEMQTKLSRMNEAQVGAQDKVSKAEIVSPVNGTV 319
+S + A + + ++ + +L + + + +++ + I +PV+ V
Sbjct: 279 ESEILSAKEEYQLVTQLFKNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKV 338

Query: 320 KTIHINTLGGVVQPGVDIIEIVPSEDKLLIETKIIPKDIAFLHPGLPAVVKVTAYDFTRY 379
+ + ++T GGVV ++ IVP +D L + + KDI F++ G A++KV A+ +TRY
Sbjct: 339 QQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRY 398

Query: 380 GGLNGVVEHISADTTQDEEGNSFYIVKVRTEFSSLTKDDGTQMPIIPGMLTSVDVITGQR 439
G L G V++I+ D +D+ + V + E + L+ +P+ GM + ++ TG R
Sbjct: 399 GYLVGKVKNINLDAIEDQRLGLVFNVIISIEENCLS-TGNKNIPLSSGMAVTAEIKTGMR 457

Query: 440 SVLEYILNPILRAKDTALRER 460
SV+ Y+L+P+ + +LRER
Sbjct: 458 SVISYLLSPLEESVTESLRER 478


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0368CABNDNGRPT671e-12 NodO calcium binding signature.
		>CABNDNGRPT#NodO calcium binding signature.

Length = 479

Score = 66.9 bits (163), Expect = 1e-12
Identities = 45/197 (22%), Positives = 68/197 (34%), Gaps = 17/197 (8%)

Query: 5201 GDDAVNAGEGNDIIFGDLVSFDGIDGQGYSALQAFVAQETSQQATDVTVQDIHDFISNNT 5260
D A + + + + G D +S + + D+ N +
Sbjct: 278 DRDFYTATDSSKALIFSVWDAGGTDTFDFSGYS----NNQRINLNEGSFSDVGGLKGNVS 333

Query: 5261 HLFGANNAE----DGADTLEGGEGNDILFGQGGNDTLIGGLDNDTMIGGLGEDTFKWTVD 5316
G G D L G ++IL G GND L GG DT+ GG G DTF +
Sbjct: 334 IAHGVTIENAIGGSGNDILVGNSADNILQGGAGNDVLYGGAGADTLYGGAGRDTFVYGSG 393

Query: 5317 SVDGTDTTDHITDFNLAEDKLDLSDILQGDTVHELAQH---------LSFTDENGSTSIN 5367
D I DF DK+DLS + + L + N T++
Sbjct: 394 QDSTVAAYDWIADFQKGIDKIDLSAFRNEGQLSFVQDQFTGKGQEVMLQWDAANSITNLW 453

Query: 5368 IDTDGNGSFDQHIVLDG 5384
+ G+ S D + + G
Sbjct: 454 LHEAGHSSVDFLVRIVG 470


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0369CABNDNGRPT803e-17 NodO calcium binding signature.
		>CABNDNGRPT#NodO calcium binding signature.

Length = 479

Score = 80.4 bits (198), Expect = 3e-17
Identities = 44/184 (23%), Positives = 71/184 (38%), Gaps = 17/184 (9%)

Query: 1822 FVEAVFTHEQIADDSITVVGTDNINNLIFGSTNTDSLTGANLDDRIFGREDNDILIGLSG 1881
F A + + + GTD + + + +L + D + G + N +
Sbjct: 281 FYTATDSSKALIFSVWDAGGTDTFDFSGYSNNQRINLNEGSFSD-VGGLKGNVSIAHGVT 339

Query: 1882 NDELIGGSGDDNIQGGEDNDFVIGGIGDDLLDGGVGRDYLSGGQGNDSLDGGELNGSDDG 1941
+ IGGSG+D + G ++ + GG G+D+L GG G D L GG G D+ G
Sbjct: 340 IENAIGGSGNDILVGNSADNILQGGAGNDVLYGGAGADTLYGGAGRDTFVYG-------- 391

Query: 1942 ERDFFVWESDTADNSTDTVFNFNPDIDVLDLSDLLIGEESGNLEDFLFFSFSGGNTTITV 2001
D+ + D + +F ID +DLS E F+ G +
Sbjct: 392 ------SGQDSTVAAYDWIADFQKGIDKIDLSAF--RNEGQLSFVQDQFTGKGQEVMLQW 443

Query: 2002 DADG 2005
DA
Sbjct: 444 DAAN 447



Score = 62.7 bits (152), Expect = 8e-12
Identities = 29/159 (18%), Positives = 46/159 (28%), Gaps = 43/159 (27%)

Query: 1833 ADDSITVVGTDNINNLIFGSTNTDSLTGANLDDRIFGREDNDILIGLSGNDELIGGSGDD 1892
++ + + + + G S+ + G NDIL+G S ++ L GG+G+D
Sbjct: 309 YSNNQRINLNEGSFSDVGGLKGNVSIAHGVTIENAIGGSGNDILVGNSADNILQGGAGND 368

Query: 1893 NIQGGEDNDFVIGGIGDDLLDGGVG-----------RDYLSGGQGNDSLDGGELNG---- 1937
+ GG D + GG G D G G D+ G D
Sbjct: 369 VLYGGAGADTLYGGAGRDTFVYGSGQDSTVAAYDWIADFQKGIDKIDLSAFRNEGQLSFV 428

Query: 1938 ----------------------------SDDGERDFFVW 1948
+ DF V
Sbjct: 429 QDQFTGKGQEVMLQWDAANSITNLWLHEAGHSSVDFLVR 467



Score = 38.4 bits (89), Expect = 3e-04
Identities = 22/116 (18%), Positives = 30/116 (25%), Gaps = 14/116 (12%)

Query: 1833 ADDSITVVGTDNINNLIFGSTN---TDSLTGANLDDRIFGREDNDILIGLSGNDELIGGS 1889
A + ++ T GA + D I + L G N G
Sbjct: 214 AVYAEDSYQFSIMSYWGENETGADYNGHYGGAPMIDDIAAIQR---LYG--ANMTTRTGD 268

Query: 1890 GDDNIQGGEDNDFVIGGIGDDLL------DGGVGRDYLSGGQGNDSLDGGELNGSD 1939
D DF L GG SG N ++ E + SD
Sbjct: 269 SVYGFNSNTDRDFYTATDSSKALIFSVWDAGGTDTFDFSGYSNNQRINLNEGSFSD 324


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0371RTXTOXIND310.008 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 31.0 bits (70), Expect = 0.008
Identities = 14/79 (17%), Positives = 28/79 (35%), Gaps = 5/79 (6%)

Query: 83 GYYFYQQLQAQQAETAELQQTLEQKLQTVLVEPNQRIASLEQQ----QNQFKSSVDLTLA 138
+ Q+ + E L ++ L + I S +++ FK+ + L
Sbjct: 247 QAIAKHAVLEQENKYVEAVNELRV-YKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLR 305

Query: 139 QTLDQQTQLEERVSIIAQR 157
QT D L ++ +R
Sbjct: 306 QTTDNIGLLTLELAKNEER 324


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0375MALTOSEBP290.003 Maltose binding protein signature.
		>MALTOSEBP#Maltose binding protein signature.

Length = 396

Score = 28.9 bits (64), Expect = 0.003
Identities = 19/62 (30%), Positives = 29/62 (46%), Gaps = 6/62 (9%)

Query: 44 QLEFDGASKIVINKQEPLHEIWLATQFGGFHFSYVDGKW------MDERNGHEFMPFLVE 97
+L+ G S ++ N QEP L GG+ F Y +GK+ +D + FLV+
Sbjct: 164 ELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVD 223

Query: 98 SI 99
I
Sbjct: 224 LI 225


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0378IGASERPTASE300.011 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 30.0 bits (67), Expect = 0.011
Identities = 20/96 (20%), Positives = 35/96 (36%), Gaps = 14/96 (14%)

Query: 165 VIEVEDVAATDVDTIGGELTNHERFPKGVNVGFMQVLNSGHIKLRVYERGAAETLACGTG 224
V EV + A+ + G + ++P V +G SG +Y++G +L
Sbjct: 174 VTEVAPIEASTASSDAGTYNDQNKYPAFVRLG------SG--SQFIYKKGDNYSLILNNH 225

Query: 225 ACAAVVVGILQGKLDRNVQVDLPGGSLM-INWDGEG 259
VG KL + G+ +N + G
Sbjct: 226 E-----VGGNNLKLVGDAYTYGIAGTPYKVNHENNG 256


5Spea_0398Spea_0406Y        NYGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_0398020-3.062214thioredoxin
Spea_0399122-2.955482ATP-dependent RNA helicase RhlB
Spea_0400224-3.496509Ppx/GppA phosphatase
Spea_0401125-3.643725TonB-dependent receptor
Spea_0402021-3.755732transposase
Spea_0403021-3.760757integrase catalytic subunit
Spea_0404022-3.305041TonB-dependent receptor
Spea_0405124-4.063843hypothetical protein
Spea_0406221-2.793236transposase IS116/IS110/IS902 family protein
6Spea_0429Spea_0451Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_04292192.471906short chain dehydrogenase
Spea_04302192.380939hypothetical protein
Spea_04312182.207828phosphoribosylamine--glycine ligase
Spea_04323172.033541bifunctional
Spea_04332181.705325zinc-responsive transcriptional regulator
Spea_04342202.122167permease
Spea_04353231.807907DSBA oxidoreductase
Spea_04363242.543154putative thiol-disulfide oxidoreductase DCC
Spea_04372213.166849molybdopterin oxidoreductase Fe4S4 region
Spea_04382193.104385formate dehydrogenase subunit alpha
Spea_04393162.521930formate dehydrogenase subunit beta
Spea_04403182.410085formate dehydrogenase subunit gamma
Spea_04413182.341220formate dehydrogenase accessory protein FdhE
Spea_04423151.645631selenocysteine synthase
Spea_04432140.801981selenocysteine-specific translation elongation
Spea_0444213-0.170631*formate dehydrogenase accessory protein
Spea_04450121.626682putative inner membrane protein
Spea_04460141.101107hypothetical protein
Spea_0447-1141.013050hypothetical protein
Spea_04481141.257984LysR family transcriptional regulator
Spea_04492121.410124hypothetical protein
Spea_04502121.297802hypothetical protein
Spea_04512140.519530N-acetyltransferase GCN5
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0429DHBDHDRGNASE702e-16 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase sig...
		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

signature.
Length = 261

Score = 70.5 bits (172), Expect = 2e-16
Identities = 49/180 (27%), Positives = 72/180 (40%), Gaps = 2/180 (1%)

Query: 7 KVIIITGASEGIGRALALALAPHGCKLVISARNLERLNSLAKELAELGTAPLVHVADVSK 66
K+ ITGA++GIG A+A LA G + N E+L + L ADV
Sbjct: 9 KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVRD 68

Query: 67 QTECAGLILACVSHFGKLDILVNNAGMTMWSRFDKLEDLSVLSQIMQVNYLGPAYLTHAA 126
+ G +DILVN AG+ L D VN G + +
Sbjct: 69 SAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEW-EATFSVNSTGVFNASRSV 127

Query: 127 IPYLK-QTQGQIVAVASLTGMTGVPTRSGYAASKHAVIGLFDSLRIELSNDNVAVTVICP 185
Y+ + G IV V S + + YA+SK A + L +EL+ N+ ++ P
Sbjct: 128 SKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSP 187


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0443TCRTETOQM571e-10 Tetracycline resistance protein TetO/TetQ/TetM family ...
		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

signature.
Length = 639

Score = 56.8 bits (137), Expect = 1e-10
Identities = 37/144 (25%), Positives = 63/144 (43%), Gaps = 18/144 (12%)

Query: 8 HVDHGKTSLIQALT---------------GTDADRLPEEKQRGMTIELGYAFMDLSDGER 52
HVD GKT+L ++L T D E+QRG+TI+ G + +
Sbjct: 11 HVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGITSFQW-ENTK 69

Query: 53 LAFVDVPGHSKFINTMLAGVSCAKHALLIIACDDGVMPQTYEHLAILQLLNLEHLIVVLT 112
+ +D PGH F+ + +S A+L+I+ DGV QT L+ + + + +
Sbjct: 70 VNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALRKMGIPTIFFI-N 128

Query: 113 KQDKVDATRVDEVKEQVSELLAQH 136
K D+ + V + + E L+
Sbjct: 129 KIDQNGI-DLSTVYQDIKEKLSAE 151


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0446PF01206921e-28 SirA family protein
		>PF01206#SirA family protein

Length = 76

Score = 91.7 bits (228), Expect = 1e-28
Identities = 19/71 (26%), Positives = 38/71 (53%)

Query: 8 DYNLEIYGEPCPYPAVATLEAMQSLKAGEVLEVITDCSQSINNIPNDAKNHGYEVLDISQ 67
D +L+ G CP P + + + ++ AGEVL V+ S+ + + +K G+E+L+ +
Sbjct: 5 DQSLDATGLNCPLPILKAKKTLATMNAGEVLYVMATDPGSVKDFESFSKQTGHELLEQKE 64

Query: 68 QGVMLRYLLKK 78
+ + LK+
Sbjct: 65 EDGTYHFRLKR 75


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0451AUTOINDCRSYN328e-04 Autoinducer synthesis protein signature.
		>AUTOINDCRSYN#Autoinducer synthesis protein signature.

Length = 216

Score = 31.7 bits (72), Expect = 8e-04
Identities = 14/63 (22%), Positives = 24/63 (38%), Gaps = 12/63 (19%)

Query: 5 SLSFSELSLNELYDLLKLRVDVFV--------VEQNCPYPELDDKDRQSQTQHLLGLNEQ 56
++ + LS + +L LR + F E D D + T +L G+ +
Sbjct: 6 DVNHTLLSETKSGELFTLRKETFKDRLNWAVQCTDGM---EFDQYDN-NNTTYLFGIKDN 61

Query: 57 GVI 59
VI
Sbjct: 62 TVI 64


7Spea_0479Spea_0503Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_0479326-0.518573cytochrome c
Spea_0480218-0.332445rhodanese domain-containing protein
Spea_04810150.862844FKBP-type peptidylprolyl isomerase
Spea_0482-2161.419404hypothetical protein
Spea_0483-1182.1179624Fe-4S ferredoxin
Spea_0484-2161.208594polysulfide reductase NrfD
Spea_0485-2160.568660NosL family protein
Spea_0486-215-0.101257periplasmic copper-binding protein
Spea_0487-216-1.093832ABC transporter-like protein
Spea_0488-118-3.990451copper ABC transporter permease
Spea_0489021-4.914502transcriptional regulator CadC
Spea_0490331-6.776919hypothetical protein
Spea_0491329-6.466674hypothetical protein
Spea_0492127-5.173242hypothetical protein
Spea_0493-120-1.470073lysine exporter protein LysE/YggA
Spea_0494-117-0.458190hypothetical protein
Spea_0495-117-0.344610hypothetical protein
Spea_0496017-0.477140hypothetical protein
Spea_0497016-0.338162hypothetical protein
Spea_04983140.192595hypothetical protein
Spea_0499320-1.462082hypothetical protein
Spea_0500318-1.402104ferredoxin
Spea_0501218-2.034209RNA polymerase sigma factor SigZ
Spea_0502219-1.561188glutathione S-transferase domain-containing
Spea_0503220-1.142052cytochrome c
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0481INFPOTNTIATR1533e-48 Macrophage infectivity potentiator signature.
		>INFPOTNTIATR#Macrophage infectivity potentiator signature.

Length = 233

Score = 153 bits (389), Expect = 3e-48
Identities = 86/234 (36%), Positives = 132/234 (56%), Gaps = 9/234 (3%)

Query: 6 KSVLAVVSCLTLSVSASCFANSDLTTDVEKESYSIGASFGHHISSQVYGQTQLGAEVDMG 65
K V A + L +S + + + LTTD +K SYSIGA G + +Q G +++
Sbjct: 4 KLVTAAIMGLAMSTAMAATDATSLTTDKDKLSYSIGADLGKNFKNQ-------GIDINPD 56

Query: 66 QVVNGLLDALQ-DETKMSKEEIVTYLNQRAETLNAAKQVKLDALTAKNLAAGEAFMAENA 124
+ G+ D + + +++E++ L++ + L A + + + +N A G+AF++ N
Sbjct: 57 VLAKGMQDGMSGAQLILTEEQMKDVLSKFQKDLMAKRSAEFNKKAEENKAKGDAFLSANK 116

Query: 125 KNSGVKQTESGLQYEVITLGEGTMPQGNDVVTVHYKGTLIDGTEFDSTYDRDEPNRFSLV 184
G+ SGLQY++I G G P +D VTV Y GTLIDGT FDST +P F +
Sbjct: 117 SKPGIVVLPSGLQYKIIDAGTGAKPGKSDTVTVEYTGTLIDGTVFDSTEKAGKPATFQVS 176

Query: 185 TVIEGWQEALALMPQGSKFKLTIPPALAYGDRVV-GMIQPHSTLVFEVELVKVE 237
VI GW EAL LMP GS +++ +P LAYG R V G I P+ TL+F++ L+ V+
Sbjct: 177 QVIPGWTEALQLMPAGSTWEVFVPADLAYGPRSVGGPIGPNETLIFKIHLISVK 230


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0490PF06340260.044 Vibrio cholerae toxin co-regulated pilus biosynthesis pr...
		>PF06340#Vibrio cholerae toxin co-regulated pilus biosynthesis

protein F (TcpF)
Length = 338

Score = 26.5 bits (58), Expect = 0.044
Identities = 14/53 (26%), Positives = 23/53 (43%), Gaps = 6/53 (11%)

Query: 38 GIKGEGHSPNYLIKNINGEKKAYKGLSHTLDPEG------DYNPNNLSQQGFS 84
G+ G N + I K Y+G L P G +Y+ + LS+ G++
Sbjct: 192 GLMGTTSVVNAIPNEIYPHIKVYEGTLSRLKPGGAMIAVLEYDVSELSKHGYT 244


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0491FbpA_PF05833260.019 Fibronectin-binding protein
		>FbpA_PF05833#Fibronectin-binding protein

Length = 577

Score = 26.0 bits (57), Expect = 0.019
Identities = 7/24 (29%), Positives = 10/24 (41%)

Query: 31 ADKATFDRFKQLAGSMTKQVMKEL 54
K DR K + + K VM +
Sbjct: 289 YAKDKSDRLKSKSSDLQKIVMNNI 312


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0497VACCYTOTOXIN290.049 Helicobacter pylori vacuolating cytotoxin signature.
		>VACCYTOTOXIN#Helicobacter pylori vacuolating cytotoxin signature.

Length = 1291

Score = 28.8 bits (64), Expect = 0.049
Identities = 20/76 (26%), Positives = 30/76 (39%), Gaps = 4/76 (5%)

Query: 119 KNALMNVTIPHSVTHIGDWAFINNALTSVTVPNSVTYIGFRAFKNNELASVSIPNSVTYM 178
NA I + THIG +A ++ P Y K N+ S + N+
Sbjct: 295 HNAAQAGIIASNKTHIGTLDLWQSAGLNIIAPPEGGY----KDKPNDKPSNTTQNNAKND 350

Query: 179 GKESFSNNALTSITIP 194
+ES NN+ T + P
Sbjct: 351 KQESSQNNSNTQVINP 366


8Spea_0532Spea_0543Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_0532-2233.593352short-chain dehydrogenase/reductase SDR
Spea_05331222.898406acetyl-CoA carboxylase, biotin carboxyl carrier
Spea_05342183.1913023-dehydroquinate dehydratase
Spea_05351163.715643peptidyl-tRNA hydrolase domain-containing
Spea_05361214.824111hypothetical protein
Spea_05370194.567406hypothetical protein
Spea_05380194.580482hypothetical protein
Spea_05390184.352623outer membrane efflux family protein
Spea_0540-1183.953022RND family efflux transporter MFP subunit
Spea_05410183.303295CzcA family heavy metal efflux protein
Spea_05422151.340386hypothetical protein
Spea_05432151.485884penicillin-insensitive murein endopeptidase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0532DHBDHDRGNASE577e-12 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase sig...
		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

signature.
Length = 261

Score = 56.6 bits (136), Expect = 7e-12
Identities = 44/184 (23%), Positives = 80/184 (43%), Gaps = 10/184 (5%)

Query: 2 ILISGASSGLGAALAKRYGAEQPICISGRNSERLQLVAKEVSQPCQAQVT-----DLCDA 56
I+GA+ G+G A+A+ A Q I+ + +L S +A+ D+ D+
Sbjct: 11 AFITGAAQGIGEAVARTL-ASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVRDS 69

Query: 57 SAVESLFDNLPTTPS---LIIHSAGSGYFGPIESQSPEAIKDLLNNNVTSAIFLLREAVK 113
+A++ + + ++++ AG G I S S E + + N T R K
Sbjct: 70 AAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRSVSK 129

Query: 114 RYKEQNV-TVVIVMSTAALVPKAEESTYCAAKWAVKGLIESVRLELKNSPMKLIAVYPGG 172
++ ++V V S A VP+ + Y ++K A + + LEL ++ V PG
Sbjct: 130 YMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSPGS 189

Query: 173 MDTD 176
+TD
Sbjct: 190 TETD 193


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0533RTXTOXIND270.031 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 27.1 bits (60), Expect = 0.031
Identities = 5/26 (19%), Positives = 16/26 (61%)

Query: 125 KSGVISAILVEDGQQVDFEQAILEIE 150
++ ++ I+V++G+ V +L++
Sbjct: 103 ENSIVKEIIVKEGESVRKGDVLLKLT 128


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0540RTXTOXIND501e-08 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 49.8 bits (119), Expect = 1e-08
Identities = 31/138 (22%), Positives = 54/138 (39%), Gaps = 9/138 (6%)

Query: 204 AVAQAQADYINAAAEWSRVKRMSASAVSASRRLQA---QVDAELKRAILEAMKMTPAQIK 260
AV + + Y+ A E K S + V K IL+ ++ T I
Sbjct: 253 AVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLRQTTDNIG 312

Query: 261 A----LANAPETIGSYQLIAPINGRVQQ-DIALLGQIVPAGTALMQLT-DESHLWVEAEL 314
LA E + + AP++ +VQQ + G +V LM + ++ L V A +
Sbjct: 313 LLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALV 372

Query: 315 TPTQAEKVSLGSKTVVKV 332
+++G ++KV
Sbjct: 373 QNKDIGFINVGQNAIIKV 390



Score = 38.7 bits (90), Expect = 4e-05
Identities = 26/140 (18%), Positives = 51/140 (36%), Gaps = 5/140 (3%)

Query: 157 VATATIVVDRDRTVTIAPQVDVRVLKRNVVPGQEVAQGDVLLTLGGV----AVAQAQADY 212
A + R+ I P + V + V G+ V +GDVLL L + + Q+
Sbjct: 85 TANGKLTHS-GRSKEIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSL 143

Query: 213 INAAAEWSRVKRMSASAVSASRRLQAQVDAELKRAILEAMKMTPAQIKALANAPETIGSY 272
+ A E +R + +S S D + + E + + + Y
Sbjct: 144 LQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKY 203

Query: 273 QLIAPINGRVQQDIALLGQI 292
Q ++ + + + +L +I
Sbjct: 204 QKELNLDKKRAERLTVLARI 223


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0541ACRIFLAVINRP6540.0 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 654 bits (1688), Expect = 0.0
Identities = 221/1091 (20%), Positives = 437/1091 (40%), Gaps = 85/1091 (7%)

Query: 5 LIDVAIRNRLLVILALIGAIIASAAMLPKLNLDAFPDVTNVQVTVNTAAEGLAAEEVEKL 64
+ + IR + + I ++A A + +L + +P + V+V+ G A+ V+
Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60

Query: 65 ISYPVESAMYALPAVTEVRSLS-RTGLSIVTVVFAEGTDIYFARQQVFEQLQAAREMIPD 123
++ +E M + + + S S G +T+ F GTD A+ QV +LQ A ++P
Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120

Query: 124 GVGVPEIGPNTSGLGQIYQYILRATPESGVNAAELRSINDYMVKLIMMPVGGVTEVLSFG 183
V I S + + ++ VK + + GV +V FG
Sbjct: 121 EVQQQGISVEKSSSSYLMVAGFVSDNPG-TTQDDISDYVASNVKDTLSRLNGVGDVQLFG 179

Query: 184 GEVRQYQVQIEPNKLLSYGLSMAQVTSALESNNRNAGGWFMDQGQE------QLVVRGYG 237
+ ++ ++ + L Y L+ V + L+ N + +
Sbjct: 180 AQ-YAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQT 238

Query: 238 MLPSGDAGLKAIAQIPLTEVA-GTPVRVGDIAKVDYGSEIRVGAVTMTRRDEAGNAQDLG 296
+ + ++ L + G+ VR+ D+A+V+ G E + N +
Sbjct: 239 RFKN----PEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARI-------NGK--- 284

Query: 297 EVVAGVVLKRMGANTKETIDDISARTAMIEQALPDGVSFEVFYDQSDLVNQAVTTVRDAL 356
+ GAN +T I A+ A ++ P G+ YD + V ++ V L
Sbjct: 285 PAAGLGIKLATGANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTL 344

Query: 357 LMAFVFIVVILALFLVNIRATMLVLLSIPVSIGLALLVMSYFGMSANLMSLGGLAVAIGM 416
A + + +++ LFL N+RAT++ +++PV + +++ FG S N +++ G+ +AIG+
Sbjct: 345 FEAIMLVFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGL 404

Query: 417 LVDGSVVMVENIFKHLTQPDRRHLANAQKRASGEDDPYHADEDGTSTASHDESSAGIAMR 476
LVD ++V+VEN+ + + + P A
Sbjct: 405 LVDDAIVVVENVERVM--------------MEDKLPPKEA-------------------- 430

Query: 477 IMLAAKEVCSPIFFATAIIIVVFAPLFALEGVEGKLFQPMAVSIILAMISALLVALIAVP 536
+ ++ + ++ VF P+ G G +++ +++I+ AM ++LVALI P
Sbjct: 431 TEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTP 490

Query: 537 ALAVYLFK----------RGVVLRESAVLKPIESVYRKLLSSTMAHPKVVGITAVVMFAM 586
AL L K G + + Y + + + ++ A
Sbjct: 491 ALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGRYLLIYALIVAG 550

Query: 587 SMMLLPRLGTEFVPELEEGTINLRVTLAPTASLATSLDVAPKLEALLLDFPEVDYALSRI 646
++L RL + F+PE ++G + L A+ + V ++ L + + S
Sbjct: 551 MVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYLKNEKANVE-SVF 609

Query: 647 GAAELGGDPEPVNNIEIYIGLKPVDEWVSASNRFE--LQRKMEEKLNVYPGLLFTFSQPI 704
+ N ++ LKP +E N E + R E + G + F+ P
Sbjct: 610 TVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKIRDGFVIPFNMP- 668

Query: 705 ATRVDELLSGVKAQLA-IKIFGPDLDVLSERGQVLTELVSQIPGAV-DVSLEQVSGEAQL 762
+ EL + I G D L++ L + +Q P ++ V + AQ
Sbjct: 669 --AIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRPNGLEDTAQF 726

Query: 763 VVRPKRDQLARYGISVDEIMALVSQGVGGASAGQVIDGNARYDIYVRLAEQYRSSPDILE 822
+ +++ G+S+ +I +S +GG ID +YV+ ++R P+ ++
Sbjct: 727 KLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADAKFRMLPEDVD 786

Query: 823 DLLLTGVSGATVRLGEVADVVIEMAPPNIRRDDVQRRVVVQANVADRDMGSVVNDIYAIV 882
L + +G V P + R + + +Q A G+ D A++
Sbjct: 787 KLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAP---GTSSGDAMALM 843

Query: 883 PQA--ELPPGYTVVVGGQYENQQRAQQKLMLVVPVSIALIALLLYFSFGSVKQVGLIMAN 940
+LP G G ++ + + +V +S ++ L L + S +M
Sbjct: 844 ENLASKLPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYESWSIPVSVMLV 903

Query: 941 VPLALIGGVVALFASGTYLSVPSSIGFITLFGVAVLNGVVLVDSINQRRSSVKEETDESL 1000
VPL ++G ++A V +G +T G++ N +++V+ E+ + +
Sbjct: 904 VPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAKDL----MEKEGKGV 959

Query: 1001 YDAVYEGTVGRLRPVLMTALTSALGLIPILLSSGVGSEIQQPLAVVIIGGLFSSTALTLL 1060
+A RLRP+LMT+L LG++P+ +S+G GS Q + + ++GG+ S+T L +
Sbjct: 960 VEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLLAIF 1019

Query: 1061 VLPTLYRWIYQ 1071
+P + I +
Sbjct: 1020 FVPVFFVVIRR 1030



Score = 106 bits (265), Expect = 3e-25
Identities = 79/552 (14%), Positives = 176/552 (31%), Gaps = 70/552 (12%)

Query: 10 IRNRLLVILALIGAIIASAAMLPKLNLDAFPDVTNVQVTVN-TAAEGLAAEEVEKLI--- 65
+ + +L + + +L P+ G E +K++
Sbjct: 534 LGSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQV 593

Query: 66 -SYPVESAMYALPAVTEVRSLSRTGLS----IVTVVFAEGTDIYFARQQVFEQLQAAREM 120
Y +++ + +V V S +G + + V + + A+
Sbjct: 594 TDYYLKNEKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKME 653

Query: 121 ---IPDGVGVPEIGPNTSGLGQIYQYILRATPESGVNAAELRSINDYMVKLIMMPVGGVT 177
I DG +P P LG + ++G+ L + ++ + +
Sbjct: 654 LGKIRDGFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLV 713

Query: 178 EVLSFGGEVRQYQVQIEPN--KLLSYGLSMAQVTSALES--NNRNAGGWFMDQGQEQLVV 233
V G Q ++E + K + G+S++ + + + + ++L V
Sbjct: 714 SVRP-NGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYV 772

Query: 234 RGYGMLPSGDAGLKAIAQIPLTEVAGTPVRVGDIAKVDYGSEIRVGAVTMTRRDEAGNAQ 293
+ + + ++ + G V + G+ + R + + +
Sbjct: 773 QADAKFRML---PEDVDKLYVRSANGEMVPFSAFTTSHWVY----GSPRLERYNGLPSME 825

Query: 294 DLGEVVAGVVLKRMGANTKETIDDISARTAMIEQALPDGVSFEVFYDQSDLVNQAVTTVR 353
GE G D A + LP G+ ++ + S +
Sbjct: 826 IQGEAAPGTSS-----------GDAMALMENLASKLPAGIGYD-WTGMSYQERLSGNQAP 873

Query: 354 DALLMAFVFIVVILALFLVNIRATMLVLLSIPVSIGLALLVMSYFGMSANLMSLGGLAVA 413
+ ++FV + + LA + + V+L +P+ I LL + F ++ + GL
Sbjct: 874 ALVAISFVVVFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTT 933

Query: 414 IGMLVDGSVVMVENIFKHLTQPDRRHLANAQKRASGEDDPYHADEDGTSTASHDESSAGI 473
IG+ ++++VE A G+ G+
Sbjct: 934 IGLSAKNAILIVE-------------FAKDLMEKEGK---------------------GV 959

Query: 474 AMRIMLAAKEVCSPIFFATAIIIVVFAPLFALEGVEGKLFQPMAVSIILAMISALLVALI 533
++A + PI + I+ PL G + + ++ M+SA L+A+
Sbjct: 960 VEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLLAIF 1019

Query: 534 AVPALAVYLFKR 545
VP V + +
Sbjct: 1020 FVPVFFVVIRRC 1031



Score = 90.3 bits (224), Expect = 2e-20
Identities = 87/480 (18%), Positives = 175/480 (36%), Gaps = 54/480 (11%)

Query: 636 FPEVDYALSRIGAAELGGDPEPV-NNIEIYI-----GLKPVDEWVSASNR---------F 680
+P + + A G D + V + + I G+ + S S+ F
Sbjct: 35 YPTIAPPAVSVSANYPGADAQTVQDTVTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTF 94

Query: 681 EL-------QRKMEEKLNVYPGLLFTFSQPIATRVDELLSGVKAQLAIKIFGPDLDVLSE 733
+ Q +++ KL + LL Q V++ S P
Sbjct: 95 QSGTDPDIAQVQVQNKLQLATPLLPQEVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDI 154

Query: 734 RGQVLTEL---VSQIPGAVDVSLEQVSGEAQLVVRPKRDQLARYGISVDEIM-ALVSQ-- 787
V + + +S++ G DV L + + + D L +Y ++ +++ L Q
Sbjct: 155 SDYVASNVKDTLSRLNGVGDVQL--FGAQYAMRIWLDADLLNKYKLTPVDVINQLKVQND 212

Query: 788 --GVGGASAGQVIDGNARYDIYVRLAEQYRSSPDILEDLLLTGVSGATVRLGEVADVVIE 845
G + G + + + ++++ + + L G+ VRL +VA V +
Sbjct: 213 QIAAGQLGGTPALPGQ-QLNASIIAQTRFKNPEEFGKVTLRVNSDGSVVRLKDVARVELG 271

Query: 846 MAPPNIR-RDDVQRRVVVQANVA-DRDMGSVVNDIYAIVP--QAELPPGYTVVVGGQYEN 901
N+ R + + + +A + I A + Q P G V+ Y+
Sbjct: 272 GENYNVIARINGKPAAGLGIKLATGANALDTAKAIKAKLAELQPFFPQGMKVLY--PYDT 329

Query: 902 QQRAQQKLMLVVP---VSIALIALLLYFSFGSVKQVGLIMANVPLALIGGVVALFASGTY 958
Q + VV +I L+ L++Y +++ + VP+ L+G L A G
Sbjct: 330 TPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGY- 388

Query: 959 LSVPSSIGFITLFGVAVLNGVVLVDSI----NQRRSSVKEETDESLYDAVYEGTVGRLRP 1014
SI +T+FG+ + G+++ D+I N R V E +A +
Sbjct: 389 -----SINTLTMFGMVLAIGLLVDDAIVVVENVER--VMMEDKLPPKEATEKSMSQIQGA 441

Query: 1015 VLMTALTSALGLIPILLSSGVGSEIQQPLAVVIIGGLFSSTALTLLVLPTLYRWIYQGRK 1074
++ A+ + IP+ G I + ++ I+ + S + L++ P L + +
Sbjct: 442 LVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATLLKPVS 501


9Spea_0621Spea_0626Y        NNGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_0621-2173.561755quinol dehydrogenase membrane component
Spea_0622-2183.515047quinol dehydrogenase periplasmic component
Spea_06230183.349901nitrate reductase catalytic subunit
Spea_06242253.467772NapD family protein
Spea_06251243.508092hypothetical protein
Spea_06261213.460800hypothetical protein
10Spea_0645Spea_0651Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_0645-3163.635327lipid A biosynthesis lauroyl (or palmitoleoyl)
Spea_0646-2173.775557bifunctional heptose 7-phosphate kinase/heptose
Spea_0647-2173.219483hypothetical protein
Spea_0648-1203.681645TetR family transcriptional regulator
Spea_0649-1183.840527MltA-interacting MipA family protein
Spea_0650-1173.961558NAD(P)(+) transhydrogenase
Spea_0651-2163.134262oxidoreductase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0646LPSBIOSNTHSS310.008 Lipopolysaccharide core biosynthesis protein signat...
		>LPSBIOSNTHSS#Lipopolysaccharide core biosynthesis protein

signature.
Length = 166

Score = 30.6 bits (69), Expect = 0.008
Identities = 10/37 (27%), Positives = 21/37 (56%)

Query: 354 GCFDILHAGHVSYLQQARALGDRLIVAVNTDASVKRL 390
G FD + GH+ +++ L D++ VAV + + + +
Sbjct: 7 GSFDPITFGHLDIIERGCRLFDQVYVAVLRNPNKQPM 43


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0648HTHTETR521e-10 TetR bacterial regulatory protein HTH signature.
		>HTHTETR#TetR bacterial regulatory protein HTH signature.

Length = 215

Score = 51.6 bits (123), Expect = 1e-10
Identities = 19/62 (30%), Positives = 35/62 (56%)

Query: 1 MAKRSKIQTEQTVQQILDEAMKQILDIGYEAMSYSTLSQATGISRTGISHHFPYKVDFLK 60
MA+++K + ++T Q ILD A++ G + S +++A G++R I HF K D
Sbjct: 1 MARKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFS 60

Query: 61 QL 62
++
Sbjct: 61 EI 62


11Spea_0699Spea_0704Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_06990143.166281sugar fermentation stimulation protein A
Spea_0700-1163.959578aminopeptidase B
Spea_07010173.281337transcriptional regulator CadC
Spea_07020173.956628hypothetical protein
Spea_07030184.2312762'-5' RNA ligase
Spea_07040174.024160ATP-dependent helicase HrpB
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0701HTHFIS392e-05 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 38.7 bits (90), Expect = 2e-05
Identities = 13/81 (16%), Positives = 26/81 (32%), Gaps = 2/81 (2%)

Query: 190 GRVLWVDDHPENNLVEKAYLEQKNIGVYNTVTSEEALMLLSMYHYQAVISDMGRHGDSLA 249
+L DD V L + V T + ++ V++D+ ++
Sbjct: 4 ATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDEN-- 61

Query: 250 GLKLLQAIRAKGNKTPFYLYT 270
LL I+ P + +
Sbjct: 62 AFDLLPRIKKARPDLPVLVMS 82


12Spea_0749Spea_0754Y        NNGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_0749-1184.524237hypothetical protein
Spea_0750-2204.351928hypothetical protein
Spea_0751-2184.233570hypothetical protein
Spea_0752-3193.945983FAD dependent oxidoreductase
Spea_0753-2173.293501chromate transporter
Spea_0754-2173.220644formate dehydrogenase subunit alpha
13Spea_0771Spea_0796Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_0771225-0.350842aromatic amino acid permease
Spea_07722210.135649L-serine dehydratase 1
Spea_07731140.401269N-acetyltransferase GCN5
Spea_0774-1150.385838hypothetical protein
Spea_0775015-0.002027sodium:dicarboxylate symporter
Spea_0776-117-0.885299hypothetical protein
Spea_0777-117-0.696634hypothetical protein
Spea_0778-115-2.487526diguanylate cyclase
Spea_0779016-3.943210N-acetyltransferase GCN5
Spea_0780120-4.829613hypothetical protein
Spea_0781020-4.562642hypothetical protein
Spea_0782018-3.110398hypothetical protein
Spea_0783126-1.298336hypothetical protein
Spea_07842230.337363hypothetical protein
Spea_07852261.672701hypothetical protein
Spea_07863342.656253N-acetyltransferase GCN5
Spea_07873352.500221S-adenosylmethionine synthetase
Spea_07882281.472531transketolase
Spea_07891180.383803erythrose 4-phosphate dehydrogenase
Spea_0790119-0.026658phosphoglycerate kinase
Spea_0791012-0.616494fructose-1,6-bisphosphate aldolase
Spea_0792-112-1.028204hypothetical protein
Spea_0793013-1.225884putative transcriptional regulator CadC
Spea_0794115-0.516521hypothetical protein
Spea_07952170.922195hypothetical protein
Spea_07962181.223440putative diguanylate cyclase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0781PHPHTRNFRASE310.004 Phosphoenolpyruvate-protein phosphotransferase sign...
		>PHPHTRNFRASE#Phosphoenolpyruvate-protein phosphotransferase

signature.
Length = 572

Score = 30.5 bits (69), Expect = 0.004
Identities = 22/99 (22%), Positives = 43/99 (43%), Gaps = 10/99 (10%)

Query: 7 TAVITATL---TIAGCAQQQESTEPQNFLTNDGNVNILWQNPSDYSDIEATTGVQSKFEQ 63
+A+++ +L + G + E + + + DG I+ NP++ +++A ++ FE
Sbjct: 191 SAIMSRSLEIPAVVGTKEVTEKIQHGDMVIVDGIEGIVIVNPTE-EEVKAYEEKRAAFE- 248

Query: 64 YLFTELTDELAKLANKH-LTKDQQLDLTVTNVDLAGDVQ 101
+ E AKL + TKD N+ DV
Sbjct: 249 ----KQKQEWAKLVGEPSTTKDGAHVELAANIGTPKDVD 283


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0786SACTRNSFRASE290.005 Streptothricin acetyltransferase signature.
		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

Length = 173

Score = 29.1 bits (65), Expect = 0.005
Identities = 14/62 (22%), Positives = 25/62 (40%), Gaps = 12/62 (19%)

Query: 70 QLAILTGMLVHPDFRGQGVGHRLM---------RELESVLCDGNTYIFALAHLEQFYAQH 120
A++ + V D+R +GVG L+ ++ + + H FYA+H
Sbjct: 88 GYALIEDIAVAKDYRKKGVGTALLHKAIEWAKENHFCGLMLETQDINISACH---FYAKH 144

Query: 121 GF 122
F
Sbjct: 145 HF 146


14Spea_1082Spea_1091Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_1082217-0.792291riboflavin biosynthesis protein RibF
Spea_1083216-0.764390isoleucyl-tRNA synthetase
Spea_1084-117-1.332396lipoprotein signal peptidase
Spea_1085121-1.887816FKBP-type peptidylprolyl isomerase
Spea_1086223-2.3786304-hydroxy-3-methylbut-2-enyl diphosphate
Spea_1087226-3.265758type IV pilus modification protein PilV
Spea_1088226-3.537136type IV pilus assembly protein PilW
Spea_1089324-3.446289type IV pilus assembly protein PilX
Spea_1090323-3.609176type IV pilin biogenesis protein
Spea_1091024-4.385602methylation site containing protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1082LPSBIOSNTHSS320.002 Lipopolysaccharide core biosynthesis protein signat...
		>LPSBIOSNTHSS#Lipopolysaccharide core biosynthesis protein

signature.
Length = 166

Score = 31.7 bits (72), Expect = 0.002
Identities = 29/154 (18%), Positives = 56/154 (36%), Gaps = 23/154 (14%)

Query: 22 GNFDGVHRGHAEVINRLVKKAEHLGLPAAVMTFEPQPRELFQGESAPARLSLLRDKIVLL 81
G+FD + GH ++I R + + + + P + +F + RL + I L
Sbjct: 7 GSFDPITFGHLDIIERGCRLFDQVYVAVLR---NPNKQPMFSVQE---RLEQIAKAIAHL 60

Query: 82 DELKIDRLLCVNFNNKFSSYSAEDFIEQLLVKALGVKYLVVGDDFCFGKQRQGNFDMLRK 141
++D F + ++ Q A+ ++ L V DF Q L
Sbjct: 61 PNAQVDS---------FEGLTV-NYARQRQAGAI-LRGLRVLSDFELELQMANTNKTLAS 109

Query: 142 AGEKFGFAVVSTQSFILGDKRVSSTEIRKLLAKG 175
E + SF+ SS+ ++++ G
Sbjct: 110 DLETVFLTTSTEYSFL------SSSLVKEVARFG 137


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1087PilS_PF08805280.027 PilS N terminal
		>PilS_PF08805#PilS N terminal

Length = 185

Score = 27.6 bits (61), Expect = 0.027
Identities = 14/71 (19%), Positives = 31/71 (43%), Gaps = 9/71 (12%)

Query: 5 EKGLSLIEVLVALVILTVGLIGVFNLHVISKRGSFESFQQTQAAYLANDIISRIKLNRSQ 64
+KG +L+EVL+ + ++ V + L+ + Q + +I+ +K + Q
Sbjct: 25 DKGATLMEVLLVVGVIVVLAASAYKLY----SMVQSNIQSSNEQNNVLTVIANMKSLKFQ 80

Query: 65 LTSYAGTYSGT 75
G Y+ +
Sbjct: 81 -----GRYTDS 86


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1091BCTERIALGSPG457e-09 Bacterial general secretion pathway protein G signa...
		>BCTERIALGSPG#Bacterial general secretion pathway protein G

signature.
Length = 145

Score = 44.9 bits (106), Expect = 7e-09
Identities = 19/59 (32%), Positives = 34/59 (57%)

Query: 5 KGFTLIELMITVAIIGILASIAYPSYIDYILQAGRSDAKVILLEAANKQEQLYLDSRTY 63
+GFTL+E+M+ + IIG+LAS+ P+ + +A + A ++ N + LD+ Y
Sbjct: 8 RGFTLLEIMVVIVIIGVLASLVVPNLMGNKEKADKQKAVSDIVALENALDMYKLDNHHY 66


15Spea_1160Spea_1171Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_11602172.490937serine hydroxymethyltransferase
Spea_11612162.639495transcriptional regulator NrdR
Spea_11620142.542078riboflavin biosynthesis protein RibD
Spea_1163-1161.777604riboflavin synthase subunit alpha
Spea_1164-1131.9139263,4-dihydroxy-2-butanone 4-phosphate synthase
Spea_11650120.5877326,7-dimethyl-8-ribityllumazine synthase
Spea_1166014-2.853119transcription antitermination protein NusB
Spea_1167014-3.037814thiamine-monophosphate kinase
Spea_1168-115-3.872056phosphatidylglycerophosphatase A
Spea_1169-117-4.346302recombination and repair protein
Spea_1170-125-5.890252transposase IS116/IS110/IS902 family protein
Spea_1171018-5.290196putative transcriptional regulator
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1169RTXTOXIND330.003 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 33.3 bits (76), Expect = 0.003
Identities = 19/161 (11%), Positives = 52/161 (32%), Gaps = 2/161 (1%)

Query: 228 RNQLHILQDNDDGSVESLLNTSISQGQDLESYDPELASVLAMLNDALIQVQESSSEIERY 287
N+L L+ D+ +++ + + L + ++ + + + +E
Sbjct: 162 LNKLPELKLPDEPYFQNVSEEEVLRLTSL--IKEQFSTWQNQKYQKELNLDKKRAERLTV 219

Query: 288 LDGLELDPEYFAHLEQRLSKTMQLARKHQVMPNELYTHHQSLLEELEDLGSDSDKLDDIR 347
L + + RL L K + + + +E + +L +L+ I
Sbjct: 220 LARINRYENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIE 279

Query: 348 EQLNANREAYLQHARKLSQSRSRYAKELDKQVTQSIHELNM 388
++ + +E Y + ++ + EL
Sbjct: 280 SEILSAKEEYQLVTQLFKNEILDKLRQTTDNIGLLTLELAK 320


16Spea_1239Spea_1278Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_1239216-2.790338extracellular solute-binding protein
Spea_1240219-2.470552hypothetical protein
Spea_1241219-2.034074hypothetical protein
Spea_1242120-2.657345hypothetical protein
Spea_1243017-2.153938diguanylate phosphodiesterase
Spea_1244019-1.412850hypothetical protein
Spea_1245019-1.493736nitroreductase A
Spea_1246-120-3.090050PEBP family protein
Spea_1247024-5.534795AraC family transcriptional regulator
Spea_1248129-8.077424alkylphosphonate utilization operon protein
Spea_1249229-8.322176AraC family transcriptional regulator
Spea_1250327-8.799244alkylhydroperoxidase
Spea_1251325-8.603154hypothetical protein
Spea_1252222-7.645247hypothetical protein
Spea_1253121-6.068852hypothetical protein
Spea_1254-118-2.720623transposase
Spea_1255-120-1.455407integrase family protein
Spea_1256021-0.099671hypothetical protein
Spea_1257119-1.933405hypothetical protein
Spea_1258221-2.926298hypothetical protein
Spea_1259221-3.357509DNA repair protein RadC
Spea_1260318-4.167730phage transcriptional regulator AlpA
Spea_1261317-3.629383hypothetical protein
Spea_1262216-3.961238hypothetical protein
Spea_1263315-3.622072hypothetical protein
Spea_1264317-3.985744hypothetical protein
Spea_1265318-3.929261hypothetical protein
Spea_1266219-2.604644hypothetical protein
Spea_1267220-2.328811hypothetical protein
Spea_1268219-1.365448hypothetical protein
Spea_1269221-1.056063helicase domain-containing protein
Spea_1270221-0.294995DNA-cytosine methyltransferase
Spea_1271221-0.507435helicase domain-containing protein
Spea_1272221-0.943489hypothetical protein
Spea_1273221-1.284269helicase domain-containing protein
Spea_1274426-3.792127hypothetical protein
Spea_1275327-6.028370hypothetical protein
Spea_1276224-5.057814hypothetical protein
Spea_1277224-4.297617hypothetical protein
Spea_1278221-3.492108hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1265IGASERPTASE451e-06 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 45.1 bits (106), Expect = 1e-06
Identities = 40/198 (20%), Positives = 71/198 (35%), Gaps = 26/198 (13%)

Query: 414 DKLNKVLNSQVMQLSASKYSLDINTLRQLLKSEETEQFSLLGLTVSLDELIPQHIQKTEQ 473
D LN L + L A KY L R L + E E+ TV + + + +
Sbjct: 951 DHLNVSLVGNTVDLGAWKYKLRNVNGRYDLYNPEVEK---RNQTVDTTNITTPNNIQADV 1007

Query: 474 ELLEERQSLTEQIADLKGLVEA-------SKQGELAEKKKDQLERAVKKCEQDLTDYQQL 526
S E+IA + S+ E + Q + V+K EQD T+
Sbjct: 1008 P---SVPSNNEEIARVDEAPVPPPAPATPSETTETVAENSKQESKTVEKNEQDATETTAQ 1064

Query: 527 QKLRDKQAERS-----EQKEVFEQDLKAINT--------ELSNAEQKHKELTDQINEIAG 573
+ K+A+ + + EV + + T E+K K T++ E+
Sbjct: 1065 NREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETKETATVEKEEKAKVETEKTQEVPK 1124

Query: 574 KLTKLIAANESVDNLKKQ 591
+++ E + ++ Q
Sbjct: 1125 VTSQVSPKQEQSETVQPQ 1142


17Spea_1304Spea_1313Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_13042181.474529hypothetical protein
Spea_13053180.4279074-hydroxy-3-methylbut-2-en-1-yl diphosphate
Spea_1306216-0.700132histidyl-tRNA synthetase
Spea_13071130.046942hypothetical protein
Spea_13082150.400671outer membrane protein assembly complex subunit
Spea_13091180.482752GTP-binding protein EngA
Spea_13101150.117020hypothetical protein
Spea_13110121.321339hypothetical protein
Spea_13121173.004651exodeoxyribonuclease VII large subunit
Spea_13132212.307099inosine 5'-monophosphate dehydrogenase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1309TCRTETOQM290.041 Tetracycline resistance protein TetO/TetQ/TetM family ...
		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

signature.
Length = 639

Score = 29.4 bits (66), Expect = 0.041
Identities = 38/159 (23%), Positives = 65/159 (40%), Gaps = 35/159 (22%)

Query: 200 IKLAIIGKPNVGKSTLTNRIL----GEERVVVYDEPGTTRDSIYIPMERQGREYVLIDTA 255
I + ++ + GK+TLT +L + D+ T D+ + +R
Sbjct: 4 INIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQR----------- 52

Query: 256 GVRRRSKVHETV---EKFSVIKT------LKAVEDSNVVL----LVIDAREGIAEQDLGL 302
G+ ++ + K ++I T L V S VL L+I A++G+ Q L
Sbjct: 53 GITIQTGITSFQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRIL 112

Query: 303 LGFVLNAGRALVIAINKWD--GID-----QNIKDRVKTE 334
+ G + INK D GID Q+IK+++ E
Sbjct: 113 FHALRKMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAE 151


18Spea_1360Spea_1369Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_1360-1133.004278flagellar hook-basal body complex subunit FliE
Spea_13612112.951209flagellar MS-ring protein
Spea_13622152.955495flagellar motor switch protein G
Spea_13631143.028097flagellar assembly protein FliH
Spea_13640142.777203flagellum-specific ATP synthase
Spea_13651161.431887flagellar export protein FliJ
Spea_13661130.605451flagellar hook-length control protein
Spea_1367115-0.018359flagellar basal body-associated protein FliL
Spea_13682170.401269flagellar motor switch protein FliM
Spea_13692190.955743flagellar motor switch protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1360FLGHOOKFLIE547e-13 Flagellar hook-basal body complex protein FliE signa...
		>FLGHOOKFLIE#Flagellar hook-basal body complex protein FliE

signature.
Length = 103

Score = 53.9 bits (129), Expect = 7e-13
Identities = 28/71 (39%), Positives = 45/71 (63%)

Query: 40 FSQLLSQAVGNVSELQSNAANLATRLDMGDTTVTLSDTVIAREKSSVAFEATVQVRNKLV 99
F+ L A+ +S+ Q+ A A + +G+ V L+D + +K+SV+ + +QVRNKLV
Sbjct: 33 FAGQLHAALDRISDTQTAARTQAEKFTLGEPGVALNDVMTDMQKASVSMQMGIQVRNKLV 92

Query: 100 EAYKEIMSMPV 110
AY+E+MSM V
Sbjct: 93 AAYQEVMSMQV 103


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1361FLGMRINGFLIF3013e-97 Flagellar M-ring protein signature.
		>FLGMRINGFLIF#Flagellar M-ring protein signature.

Length = 559

Score = 301 bits (771), Expect = 3e-97
Identities = 156/563 (27%), Positives = 263/563 (46%), Gaps = 49/563 (8%)

Query: 30 LGGVDMLRQLTMILALAICLAVAVFVMIWAQEPEYRPL-GQMSTAEMVQVLDALDKNQVK 88
L + ++ +I+A + +A+ V +++WA+ P+YR L +S + ++ L + +
Sbjct: 16 LNRLRANPRIPLIVAGSAAVAIVVAMVLWAKTPDYRTLFSNLSDQDGGAIVAQLTQMNIP 75

Query: 89 YEIQGD--VVKVPEDKYQDVKMLLSREGLDNQEANNDFLNKDSGFGVSQRMEQARLKHSQ 146
Y ++VP DK ++++ L+++GL A L FG+SQ EQ + +
Sbjct: 76 YRFANGSGAIEVPADKVHELRLRLAQQGLPKGGAVGFELLDQEKFGISQFSEQVNYQRAL 135

Query: 147 EQNLARVIEELKSVTRAKVILALPRENVFARNRSKPSATVVVSTRRS-GLSQEEVDSIVD 205
E LAR IE L V A+V LA+P+ ++F R + PSA+V V+ L + ++ ++V
Sbjct: 136 EGELARTIETLGPVKSARVHLAMPKPSLFVREQKSPSASVTVTLEPGRALDEGQISAVVH 195

Query: 206 IVASAVHNLEPNKVTVTDANGRLLNSGTQDGASAIARRELEIVQQKESEYRTKVESILMP 265
+V+SAV L P VT+ D +G LL G +L+ ES + ++E+IL P
Sbjct: 196 LVSSAVAGLPPGNVTLVDQSGHLLTQSNTSGRDL-NDAQLKFANDVESRIQRRIEAILSP 254

Query: 266 ILGPENFTSQVDVSMDFTAVEQTAKRYNPDLPALRSEMVVENNS-----AGGTSGGIPGA 320
I+G N +QV +DF EQT + Y+P+ A ++ + + G GG+PGA
Sbjct: 255 IVGNGNVHAQVTAQLDFANKEQTEEHYSPNGDASKATLRSRQLNISEQVGAGYPGGVPGA 314

Query: 321 LSNQPP---------------MAADIPQEVNAEESLAVSSGTSHKEATRNFELNTTISHT 365
LSNQP A + PQ + S + ++ + T N+E++ TI HT
Sbjct: 315 LSNQPAPPNEAPIATPPTNQQNAQNTPQTSTSTNSNSAGPRSTQRNETSNYEVDRTIRHT 374

Query: 366 RQQVGTLRRVSVSVAVDFKNGPVSEDGSVNRVPRTEQELANIRRLLEGAVGFNTQRGDII 425
+ VG + R+SV+V V++K + +P T ++ I L A+GF+ +RGD +
Sbjct: 375 KMNVGDIERLSVAVVVNYKTLADGKP-----LPLTADQMKQIEDLTREAMGFSDKRGDTL 429

Query: 426 EVVSVPFMDQLIEDAPPQEMWEQPWFWRAVKLVLGALVVLV----LILAVVRPMLKRLVY 481
VV+ PF + W+Q F + L+VLV L VRP L R V
Sbjct: 430 NVVNSPF-SAVDNTGGELPFWQQQSFIDQLLAAGRWLLVLVVAWILWRKAVRPQLTRRV- 487

Query: 482 PDSVKMPDEPQTGGELAEIEDQYAADTLGMLQRPEAEYSYADDGSILIPNLHKDDDMIKA 541
+ K E + E + LQ+ A + + + M +
Sbjct: 488 -EEAKAAQEQAQVRQETEEAVEVRLSKDEQLQQRRA--------NQRLGA----EVMSQR 534

Query: 542 IRALVANEPELSTQVVKNWLLED 564
IR + N+P + V++ W+ D
Sbjct: 535 IREMSDNDPRVVALVIRQWMSND 557


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1362FLGMOTORFLIG2871e-97 Flagellar motor switch protein FliG signature.
		>FLGMOTORFLIG#Flagellar motor switch protein FliG signature.

Length = 344

Score = 287 bits (735), Expect = 1e-97
Identities = 109/343 (31%), Positives = 191/343 (55%)

Query: 7 VEAKPEAAALKTSDLSGIEKTAILLLSLSESDAASILKHLEPKQVQKVGMAMAAMQDFGQ 66
+E K E L S L+G +K AILL+S+ ++ + K+L ++++ + +A ++
Sbjct: 1 MEEKKEKEILDVSALTGKQKAAILLVSIGSEISSKVFKYLSQEEIESLTFEIAKLETITS 60

Query: 67 EKVIGVHKLFLDEIQKYSSIGFNSEEFVRKALTAALGEDKAGNLIEQIIMGGGAKGLDSL 126
E V F + + I ++ R+ L +LG KA ++I + ++ + +
Sbjct: 61 ELKDNVLLEFKELMMAQEFIQKGGIDYARELLEKSLGTQKAVDIINNLGSALQSRPFEFV 120

Query: 127 KWMDARQVATIIQNEHPQIQTIVLSYLEPDQAAEIFGQFPENTRLDLMMRIANLEEVQPA 186
+ D + IQ EHPQ ++LSYL+P +A+ I P + ++ RIA ++ P
Sbjct: 121 RRADPANILNFIQQEHPQTIALILSYLDPQKASFILSSLPTEVQTNVARRIALMDRTSPE 180

Query: 187 ALQELNDIMEKQFAGQGGAQAAKMGGLKAAANIMNYLDTGVESHLMETMRESDEEMAQQI 246
++E+ ++EK+ A GG+ I+N D E ++E++ E D E+A++I
Sbjct: 181 VVREVERVLEKKLASLSSEDYTSAGGVDNVVEIINMADRKTEKFIIESLEEEDPELAEEI 240

Query: 247 QDLMFVFENLSEVDDMGIQVLLREVQQDVLIKALKGADDQLKEKLLSNMSKRAAELLRDD 306
+ MFVFE++ +DD IQ +LRE+ L KALK D ++EK+ NMSKRAA +L++D
Sbjct: 241 KKKMFVFEDIVLLDDRSIQRVLREIDGQELAKALKSVDIPVQEKIFKNMSKRAASMLKED 300

Query: 307 LEAMGPIRISEVEVAQKEILSIARRLSDSGEIMLGGGGGEEFL 349
+E +GP R +VE +Q++I+S+ R+L + GEI++ GG E+ L
Sbjct: 301 MEFLGPTRRKDVEESQQKIVSLIRKLEEQGEIVISRGGEEDVL 343


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1363FLGFLIH771e-18 Flagellar assembly protein FliH signature.
		>FLGFLIH#Flagellar assembly protein FliH signature.

Length = 228

Score = 76.8 bits (188), Expect = 1e-18
Identities = 57/205 (27%), Positives = 99/205 (48%), Gaps = 4/205 (1%)

Query: 47 AEEQTEVESILPPTLSEIEDIRAHAEQEGFG---EGLEKGHSEGLEKGRLEGLEQGHSEG 103
A Q E I+ P + IE+ EQ+ + E+G+ G+ +GR +G +QG+ EG
Sbjct: 16 APPQAEFVPIVEPEETIIEEAEPSLEQQLAQLQMQAHEQGYQAGIAEGRQQGHKQGYQEG 75

Query: 104 FSQGQQQGYLEGLQAASEMLQRFESLLSQFEAPLSILDTEIEKELLNTSMVLAKAVIGHE 163
+QG +QG E + + R + L+S+F+ L LD+ I L+ ++ A+ VIG
Sbjct: 76 LAQGLEQGLAEAKSQQAPIHARMQQLVSEFQTTLDALDSVIASRLMQMALEAARQVIGQT 135

Query: 164 LKTYPEHILAALRQGVDSLPIKDQKINVRVTPSDEILISELYSQAQLERNRWEIEADPSL 223
++ ++Q + P+ K +RV P D + ++ A L + W + DP+L
Sbjct: 136 PTVDNSALIKQIQQLLQQEPLFSGKPQLRVHPDDLQRVDDMLG-ATLSLHGWRLRGDPTL 194

Query: 224 TAGDCIIDCGRSHIDMTVETRIQSV 248
G C + +D +V TR Q +
Sbjct: 195 HPGGCKVSADEGDLDASVATRWQEL 219


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1365FLGFLIJ413e-07 Flagellar FliJ protein signature.
		>FLGFLIJ#Flagellar FliJ protein signature.

Length = 147

Score = 40.6 bits (94), Expect = 3e-07
Identities = 40/145 (27%), Positives = 70/145 (48%)

Query: 1 MARADPLLMVLKLAEDAEEQASLQLRSAQLELQRRQNQLDALQNYRLDYMKQMEQQQGQS 60
MA L + LAE E A+ L + Q+ + QL L +Y+ +Y +
Sbjct: 1 MAEHGALATLKDLAEKEVEDAARLLGEMRRGCQQAEEQLKMLIDYQNEYRNNLNSDMSAG 60

Query: 61 ISASHYHQFHQFVRQIDTAIIQQVNTVQDADNQRQHRQVYWQEKQQKRKAVELLLANKAE 120
I+++ + + QF++ ++ AI Q + + W+EK+Q+ +A + L ++
Sbjct: 61 ITSNRWINYQQFIQTLEKAITQHRQQLNQWTQKVDIALNSWREKKQRLQAWQTLQERQST 120

Query: 121 KAQLAELRAEQKMVDEFASQQFYRK 145
A LAE R +QK +DEFA + RK
Sbjct: 121 AALLAENRLDQKKMDEFAQRAAMRK 145


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1366FLGHOOKFLIK485e-08 Flagellar hook-length control protein signature.
		>FLGHOOKFLIK#Flagellar hook-length control protein signature.

Length = 375

Score = 47.9 bits (113), Expect = 5e-08
Identities = 32/109 (29%), Positives = 55/109 (50%), Gaps = 1/109 (0%)

Query: 381 MNQQLITMVSNGIQQAEIRLDPPELGQMMVRIQVQGDTTQVQFQVSQHQTRDLVEQAMPR 440
++Q + G Q AE+RL P +LG++ + ++V + Q+Q R +E A+P
Sbjct: 244 LSQHISLFTRQGQQSAELRLHPQDLGEVQISLKVDDNQAQIQMVSPHQHVRAALEAALPV 303

Query: 441 LREMLAEQGMQLTDGQVSQGDGRNSQGEQGSGAGNGTATAETDEISSEE 489
LR LAE G+QL +S G+ + Q + S TA + ++ E+
Sbjct: 304 LRTQLAESGIQLGQSNIS-GESFSGQQQAASQQQQSQRTANHEPLAGED 351


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1368FLGMOTORFLIM2495e-83 Flagellar motor switch protein FliM signature.
		>FLGMOTORFLIM#Flagellar motor switch protein FliM signature.

Length = 344

Score = 249 bits (638), Expect = 5e-83
Identities = 87/326 (26%), Positives = 168/326 (51%), Gaps = 11/326 (3%)

Query: 1 MSDLLSQDEIDALLHGVDDVEEDMID----DNELDARSYDFSSQDRIVRGRMPTLEIVNE 56
M+++LSQDEID LL + + + D + YDF D+ + +M TL +++E
Sbjct: 1 MTEVLSQDEIDQLLTAISSGDASIEDARPISDTRKITLYDFRRPDKFSKEQMRTLSLMHE 60

Query: 57 RFARHLRISMFNMMRRAAEVSINGVQMLKFGEYVHTLFVPTSLNMVRFSPLKGTALITME 116
FAR S+ +R V + V L + E++ ++ P++L ++ PLKG A++ ++
Sbjct: 61 TFARLTTTSLSAQLRSMVHVHVASVDQLTYEEFIRSIPTPSTLAVITMDPLKGNAVLEVD 120

Query: 117 ARLVFILVDNFFGGDGRFHAKIEGREFTPTERRIVQLLLKIIFEDYKEAWAPVMEVQFDY 176
+ F ++D FGG G+ R+ T E +++ ++ I + +E+W V++++
Sbjct: 121 PSITFSIIDRLFGGTGQAAKVQ--RDLTDIENSVMEGVIVRILANVRESWTQVIDLRPRL 178

Query: 177 LDSEVNPAMANIVSPTEVVVVSSFHIEVDGGGGDFHITMPYSMIEPIRELLDAG--VQSD 234
E NP A IV P+E+VV+ + +V G + +PY IEPI L + S
Sbjct: 179 GQIETNPQFAQIVPPSEMVVLVTLETKVGEEEGMMNFCIPYITIEPIISKLSSQFWFSSV 238

Query: 235 TQDTDMRWSQALRDEIMDVDVGIDATIVEHKLTLREVLEFKAGDVIPVE---LPEHIILK 291
+ + ++ LRD++ VD+ + A + +L++R++L + GD+I + + + +L
Sbjct: 239 RRSSTTQYMGVLRDKLSTVDMDVVAEVGSLRLSVRDILGLRVGDIIRLHDTHVGDPFVLS 298

Query: 292 VEDLPTYRCKMGKAKDNLALKICEKI 317
+ + + C+ G +A +I E+I
Sbjct: 299 IGNRKKFLCQPGVVGKKIAAQILERI 324


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1369FLGMOTORFLIN1132e-35 Flagellar motor switch protein FliN signature.
		>FLGMOTORFLIN#Flagellar motor switch protein FliN signature.

Length = 137

Score = 113 bits (283), Expect = 2e-35
Identities = 57/119 (47%), Positives = 81/119 (68%)

Query: 7 DDWAAAMAEQAIEEAKAVELDEFNSDGAPLSEEEASKLDAIMDIPVTISMEVGRSFINIR 66
D WA A+ EQ K+ F G +D IMDIPV +++E+GR+ + I+
Sbjct: 17 DLWADALNEQKATTTKSAADAVFQQLGGGDVSGAMQDIDLIMDIPVKLTVELGRTRMTIK 76

Query: 67 NLLQLNQGSVVELDRVAGEPLDVMVNGTLIAHGEVVVVNDKFGIRLTDVISQTERIKKL 125
LL+L QGSVV LD +AGEPLD+++NG LIA GEVVVV DK+G+R+TD+I+ +ER+++L
Sbjct: 77 ELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVVADKYGVRITDIITPSERMRRL 135


19Spea_1394Spea_1414Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_1394-220-3.540366transcriptional acivator RfaH
Spea_1395-222-4.249523polysaccharide export protein
Spea_1396031-7.463373hypothetical protein
Spea_1397134-9.066545lipopolysaccharide biosynthesis protein
Spea_1398238-10.576740dTDP-glucose-4,6-dehydratase
Spea_1399342-11.301017glucose-1-phosphate thymidylyltransferase
Spea_1400343-11.445095WxcM domain-containing protein
Spea_1401240-11.165059N-acetyltransferase GCN5
Spea_1402239-11.284788hypothetical protein
Spea_1403338-10.797407DegT/DnrJ/EryC1/StrS aminotransferase
Spea_1404339-11.092971hypothetical protein
Spea_1405438-11.889153peptidase C26
Spea_1406438-12.280054nucleotidyl transferase
Spea_1407441-12.486270CDP-glycerol:poly(glycerophosphate)
Spea_1408342-11.494292polysaccharide biosynthesis protein
Spea_1409444-11.657215group 1 glycosyl transferase
Spea_1410036-8.554151hypothetical protein
Spea_1411-128-6.209606glycosyl transferase family protein
Spea_1412-123-5.081259glycosyl transferase family protein
Spea_1413-120-4.239040DegT/DnrJ/EryC1/StrS aminotransferase
Spea_1414-116-3.159679sugar transferase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1396NUCEPIMERASE280.008 Nucleotide sugar epimerase signature.
		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

Length = 334

Score = 28.2 bits (63), Expect = 0.008
Identities = 17/88 (19%), Positives = 32/88 (36%), Gaps = 10/88 (11%)

Query: 21 EIYKELNTCRDFGLKDQITRAAVSIASNIAEGEERES------KAESARFLYFAKGSSGE 74
++Y RDF D I A + + I + + + A A + + G+S
Sbjct: 206 DVYNYGKMKRDFTYIDDIAEAIIRLQDVIPHADTQWTVETGTPAASIAPYRVYNIGNSSP 265

Query: 75 LATQIYIAIEIGVIEKQIGLKLIKEARE 102
+ YI +E +G++ K
Sbjct: 266 VELMDYIQA----LEDALGIEAKKNMLP 289


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1398NUCEPIMERASE1791e-55 Nucleotide sugar epimerase signature.
		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

Length = 334

Score = 179 bits (455), Expect = 1e-55
Identities = 80/356 (22%), Positives = 142/356 (39%), Gaps = 48/356 (13%)

Query: 1 MKILVTGGAGFIGSAVVRHIINNTQDSVINVDKLT--YAGNL-ESLSSIESNERYVFEQV 57
MK LVTG AGFIG V + ++ V+ +D L Y +L ++ + + + F ++
Sbjct: 1 MKYLVTGAAGFIGFHVSKRLLEAG-HQVVGIDNLNDYYDVSLKQARLELLAQPGFQFHKI 59

Query: 58 DICDRAELDRVFAQCQPNAVMHLAAESHVDRSITGPADFIQTNIVGTYTLLEATRAYWNT 117
D+ DR + +FA V V S+ P + +N+ G +LE R
Sbjct: 60 DLADREGMTDLFASGHFERVFISPHRLAVRYSLENPHAYADSNLTGFLNILEGCRHN--- 116

Query: 118 LSKGAKQAFRFHHISTDEVYGDLPHPDEVESGKELPLFTETTAYEPSSPYSASKASSDHL 177
+ + S+ VYG +P T+ + P S Y+A+K +++ +
Sbjct: 117 ------KIQHLLYASSSSVYGLNRK---------MPFSTDDSVDHPVSLYAATKKANELM 161

Query: 178 VRAWLRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKPLPIYGKGDQIRDWLYVE 237
+ YGLP YGP+ P+ + LEGK + +Y G RD+ Y++
Sbjct: 162 AHTYSHLYGLPATGLRFFTVYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYID 221

Query: 238 DHARALYKVV------------------TEGLVGETYNIGGHNEKQNLEVVQTICSILDF 279
D A A+ ++ YNIG + + ++ +Q + L
Sbjct: 222 DIAEAIIRLQDVIPHADTQWTVETGTPAASIAPYRVYNIGNSSPVELMDYIQALEDALGI 281

Query: 280 LVPKETKYSQQITYVTDRPGHDRRYAIDSSKMQRELGWTPVETFETGLRKTIEWYL 335
K + +PG + D+ + +G+TP T + G++ + WY
Sbjct: 282 EAKKN--------MLPLQPGDVLETSADTKALYEVIGFTPETTVKDGVKNFVNWYR 329


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1404PHPHTRNFRASE399e-05 Phosphoenolpyruvate-protein phosphotransferase sign...
		>PHPHTRNFRASE#Phosphoenolpyruvate-protein phosphotransferase

signature.
Length = 572

Score = 39.0 bits (91), Expect = 9e-05
Identities = 13/48 (27%), Positives = 20/48 (41%), Gaps = 7/48 (14%)

Query: 918 MIPQADPGYDWLFGHEIGGLITKYGGANSHMAIRAAEIGLPAAIGVGE 965
Q + + + G T GG SH AI + + +PA +G E
Sbjct: 168 DTAQLNKQF-------VKGFATDIGGRTSHSAIMSRSLEIPAVVGTKE 208


20Spea_1486Spea_1526Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_1486215-0.593055serine O-acetyltransferase
Spea_14870140.250584BadM/Rrf2 family transcriptional regulator
Spea_14881150.205787cysteine desulfurase
Spea_1489113-0.140745scaffold protein
Spea_1490115-1.002027iron-sulfur cluster assembly protein IscA
Spea_1491116-1.165503co-chaperone HscB
Spea_1492016-1.047492chaperone protein HscA
Spea_1493121-3.710181ferredoxin, 2Fe-2S type, ISC system
Spea_1494426-3.142911transposase
Spea_1495426-2.905855integrase catalytic subunit
Spea_1496323-1.376100hypothetical protein
Spea_1497223-0.753700hypothetical protein
Spea_1498220-1.098528nucleoside diphosphate kinase
Spea_1499115-1.649909TonB-dependent receptor
Spea_1500-115-1.300286TraR/DksA family transcriptional regulator
Spea_1501016-1.706118dihydrouridine synthase
Spea_1502118-3.385221hypothetical protein
Spea_1503214-0.992420hypothetical protein
Spea_1504414-0.399092hypothetical protein
Spea_1505314-0.372099hypothetical protein
Spea_1506313-0.516987hypothetical protein
Spea_1507312-0.304947adenine phosphoribosyltransferase
Spea_1508-114-0.972443DNA polymerase III subunits gamma and tau
Spea_1509-117-2.468528hypothetical protein
Spea_1510018-2.091782acetyltransferase
Spea_1511-117-1.887165Sel1 domain-containing protein
Spea_1512-118-2.028552hypothetical protein
Spea_1513018-2.028830TonB-dependent receptor
Spea_1514219-1.443038kelch repeat-containing protein
Spea_1515219-1.329499exo-alpha-sialidase
Spea_1516319-1.866928putative hydrolase
Spea_1517321-1.774902transcriptional regulator NanR
Spea_1518320-1.577807SSS family solute/sodium (Na+) symporter
Spea_1519322-2.029996N-acetylmannosamine-6-phosphate 2-epimerase
Spea_1520221-1.821182ROK family protein
Spea_1521-114-1.433732glucosamine-6-phosphate isomerase
Spea_1522012-1.115374dihydrodipicolinate synthetase
Spea_1523013-0.871955N-acetylglucosamine-6-phosphate deacetylase
Spea_1524015-0.204450hypothetical protein
Spea_15252180.423047recombination protein RecR
Spea_1526218-0.212915heat shock protein 90
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1488PF07328280.024 T-DNA border endonuclease VirD1
		>PF07328#T-DNA border endonuclease VirD1

Length = 144

Score = 28.5 bits (63), Expect = 0.024
Identities = 13/54 (24%), Positives = 19/54 (35%), Gaps = 2/54 (3%)

Query: 329 TSASLEP-SYVLRALGLNDEMAHSSIRFSIGRFT-TDEEIDHAIETIKESIGNL 380
T A L + LGLN A IG F D + + + +I +
Sbjct: 28 TEAELAEFDAQIAELGLNRNRALRIAARRIGGFVENDAKTVELLRDMSRAIAGV 81


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1492SHAPEPROTEIN1119e-29 Bacterial cell shape determinant MreB/Mbl protein s...
		>SHAPEPROTEIN#Bacterial cell shape determinant MreB/Mbl protein

signature.
Length = 347

Score = 111 bits (278), Expect = 9e-29
Identities = 76/373 (20%), Positives = 137/373 (36%), Gaps = 72/373 (19%)

Query: 22 VGIDLGTTNSLVAAVRSGVANTLPDEDSQHSLPSVVRYTQDS-------VLVGREAEAFS 74
+ IDLGT N+L+ G+ + PSVV QD VG +A+
Sbjct: 13 LSIDLGTANTLIYVKGQGIV---------LNEPSVVAIRQDRAGSPKSVAAVGHDAKQML 63

Query: 75 AQDPQNTIVSIKRFMGRSLEDIQSGDQTLPYIFEASENGLPIFVTPSGKVNPVQISSEIL 134
+ P N I +I+ + D ++ L + + +V+
Sbjct: 64 GRTPGN-IAAIRPMKDGVIADFFVTEKMLQHFIK--------------QVHSNSFMRPSP 108

Query: 135 KPLVARAELTLGGTLEGVVITVPAYFDDAQRQGTKDAASLTGVKVLRLLNEPTAAAIAYG 194
+ V++ VP +R+ +++A G + + L+ EP AAAI G
Sbjct: 109 R----------------VLVCVPVGATQVERRAIRESAQGAGAREVFLIEEPMAAAIGAG 152

Query: 195 LDSGQEGVIAVYDLGGGTFDISILRLNKGVFEVLATGGDSALGGDDFDHMLQAYFAEQWQ 254
L + V D+GGGT +++++ LN V +GGD FD + Y +
Sbjct: 153 LPVSEATGSMVVDIGGGTTEVAVISLNGVV-----YSSSVRIGGDRFDEAIINYVRRNYG 207

Query: 255 VSSASASMNR-KMQIEARRVKEALTESAETTASVVDDAGTKLTLTVTRELFDSL------ 307
A+ R K +I + + + E ++ + TL + E+ ++L
Sbjct: 208 SLIGEATAERIKHEIGSAYPGDEVREIEVRGRNLAEGVPRGFTLN-SNEILEALQEPLTG 266

Query: 308 IAKLVKKTISSC----RRALRDAGVSNDEVLETVMVGGSTRVPLVRQEVESFMGKTPLTS 363
I V + C + + G+ V+ GG + + + + G + +
Sbjct: 267 IVSAVMVALEQCPPELASDISERGM--------VLTGGGALLRNLDRLLMEETGIPVVVA 318

Query: 364 IDPDRVVAIGAAI 376
DP VA G
Sbjct: 319 EDPLTCVARGGGK 331


21Spea_1664Spea_1669Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_1664226-1.330601D-erythro-7,8-dihydroneopterin triphosphate
Spea_1665227-1.092402hypothetical protein
Spea_1666228-1.057434hypothetical protein
Spea_1667540-0.539067hypothetical protein
Spea_1668441-0.197502phosphate acetyltransferase
Spea_1669331-0.260584acetate kinase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1669ACETATEKNASE502e-180 Acetate kinase family signature.
		>ACETATEKNASE#Acetate kinase family signature.

Length = 400

Score = 502 bits (1293), Expect = e-180
Identities = 185/398 (46%), Positives = 265/398 (66%), Gaps = 8/398 (2%)

Query: 6 VLVLNCGSSSLKFAVIDALTGDDQISGLAECFGLEDSRIKWKVNGQKSEASLGAFTAHRE 65
+LV+NCGSSSLK+ +I++ G+ GLAE G+ DS + NG+K + H++
Sbjct: 3 ILVINCGSSSLKYQLIESKDGNVLAKGLAERIGINDSLLTHNANGEKIKIKKD-MKDHKD 61

Query: 66 AVEYIVNDILGAHPEIA---AEIQAIGHRVVHGGEKFTRSVIIDESVIHGIEDCATLAPL 122
A++ +++ ++ + + +EI A+GHRVVHGGE FT SV+I + V+ I DC LAPL
Sbjct: 62 AIKLVLDALVNSDYGVIKDMSEIDAVGHRVVHGGEYFTSSVLITDDVLKAITDCIELAPL 121

Query: 123 HNPAHLIGIRAAQASFPALPQVAVFDTAFHQTMPEKAYIYALPYKLYRENAIRRYGMHGT 182
HNPA++ GI+A P +P VAVFDTAFHQTMP+ AY+Y +PY+ Y + IR+YG HGT
Sbjct: 122 HNPANIEGIKACTQIMPDVPMVAVFDTAFHQTMPDYAYLYPIPYEYYTKYKIRKYGFHGT 181

Query: 183 SHLFISREAAAALGKDEADTNIICAHLGNGASVTAIKGGKSVDTSMGLTPLEGLVMGTRC 242
SH ++S+ AA L K II HLGNG+S+ A+K GKS+DTSMG TPLEGL MGTR
Sbjct: 182 SHKYVSQRAAEILNKPIESLKIITCHLGNGSSIAAVKNGKSIDTSMGFTPLEGLAMGTRS 241

Query: 243 GDLDPSVIFHLVNRLGYTLDEVESVLNKQSGLLGISELTNDCRGIEEG-FGSGHKGATLA 301
G +DPS+I +L+ + + +EV ++LNK+SG+ GIS +++D R +E+ F +G K A LA
Sbjct: 242 GSIDPSIISYLMEKENISAEEVVNILNKKSGVYGISGISSDFRDLEDAAFKNGDKRAQLA 301

Query: 302 LEIFCYRLAKYIASYTVPLERLDAVVFTGGIGENSDLIREKVLNSLAIFNFNVDKERNAA 361
L +F YR+ K I SY + +D +VFT GIGEN IRE +L+ L F +DKE+N
Sbjct: 302 LNVFAYRVKKTIGSYAAAMGGVDVIVFTAGIGENGPEIREFILDGLEFLGFKLDKEKNKV 361

Query: 362 ARFGNGGQITTDEGTV-AMVIPTNEEWVIAQDAIELIK 398
G I+T + V MV+PTNEE++IA+D ++++
Sbjct: 362 R--GEEAIISTADSKVNVMVVPTNEEYMIAKDTEKIVE 397


22Spea_1782Spea_1787Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_17823260.558197citrate synthase I
Spea_17833211.065155type II citrate synthase
Spea_17843221.265968succinate dehydrogenase cytochrome b556 subunit
Spea_17853241.152449succinate dehydrogenase hydrophobic membrane
Spea_17863271.149534succinate dehydrogenase flavoprotein subunit
Spea_17873260.574488succinate dehydrogenase iron-sulfur subunit
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1785TYPE3OMOPROT280.009 Type III secretion system outer membrane O protein ...
		>TYPE3OMOPROT#Type III secretion system outer membrane O protein

family signature.
Length = 303

Score = 27.7 bits (61), Expect = 0.009
Identities = 12/28 (42%), Positives = 16/28 (57%)

Query: 5 TNAASLGRSGVHDFILIRASAVVLACYT 32
T + LGR G+ D +LIR S + CY
Sbjct: 161 TQRSLLGRIGIGDVLLIRTSRAEVYCYA 188


23Spea_1864Spea_1912Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_1864214-0.019110gamma-glutamyltransferase
Spea_1865020-4.083439hypothetical protein
Spea_1866025-6.549041hypothetical protein
Spea_1867327-8.535443hypothetical protein
Spea_1868323-7.835349hypothetical protein
Spea_1869219-6.468086lysine exporter protein LysE/YggA
Spea_1870220-6.297566hypothetical protein
Spea_1871118-5.748322hypothetical protein
Spea_1872013-3.594955hypothetical protein
Spea_1873-215-0.4965094-hydroxyphenylpyruvate dioxygenase
Spea_1874-115-0.212594homogentisate 12-dioxygenase
Spea_1875118-0.915536LysR family transcriptional regulator
Spea_1876117-1.235077hypothetical protein
Spea_1877014-1.239986cytochrome-c peroxidase
Spea_1878219-1.761918integral membrane protein TerC
Spea_1879117-2.157094ABC transporter
Spea_1880015-2.368165alpha/beta hydrolase fold protein
Spea_1881-214-3.333060hypothetical protein
Spea_1882-120-5.353501hypothetical protein
Spea_1883024-6.665326hypothetical protein
Spea_1884-126-6.750327hypothetical protein
Spea_1885027-6.503800mechanosensitive ion channel protein MscS
Spea_1886328-7.706185hypothetical protein
Spea_1887229-7.699195phage exclusion protein Lit
Spea_1888330-7.105998hypothetical protein
Spea_1890228-6.872665hypothetical protein
Spea_1891326-7.056236XRE family transcriptional regulator
Spea_1892119-6.249354hypothetical protein
Spea_1893219-6.222277type III restriction protein res subunit
Spea_1894219-5.782189hypothetical protein
Spea_1895118-5.169646hypothetical protein
Spea_1896117-4.790523hypothetical protein
Spea_1897015-4.693410integrase family protein
Spea_1898113-4.464830hypothetical protein
Spea_1899012-1.990150integrase family protein
Spea_1900-212-0.696759mechanosensitive ion channel protein MscS
Spea_1901-211-0.751442response regulator receiver modulated CheW
Spea_1902-113-0.089043hypothetical protein
Spea_1903117-0.476683hypothetical protein
Spea_1904116-0.638155lytic murein transglycosylase
Spea_1905218-1.461732FKBP-type peptidylprolyl isomerase
Spea_1906214-0.956033hypothetical protein
Spea_1907011-0.577093carboxylesterase
Spea_1908-111-0.649915bifunctional UDP-sugar hydrolase/5'-nucleotidase
Spea_1909-112-0.061085heat shock protein Hsp20
Spea_1910-213-0.178972acetolactate synthase small subunit
Spea_1911-213-0.996175acetolactate synthase large subunit
Spea_1912214-1.344372Bcr/CflA subfamily drug resistance transporter
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1892PF05616300.007 Neisseria meningitidis TspB protein
		>PF05616#Neisseria meningitidis TspB protein

Length = 501

Score = 29.7 bits (66), Expect = 0.007
Identities = 18/41 (43%), Positives = 21/41 (51%), Gaps = 4/41 (9%)

Query: 130 GESEEYMRL---YKSFPEMKEHLESQ-YMLARESSSKLLGQ 166
G MRL Y FPE+KE +ESQ LAR KL +
Sbjct: 146 GVDSSIMRLMSDYSRFPEVKELMESQMERLARPYWEKLRNR 186


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1896FbpA_PF05833316e-04 Fibronectin-binding protein
		>FbpA_PF05833#Fibronectin-binding protein

Length = 577

Score = 31.4 bits (71), Expect = 6e-04
Identities = 13/52 (25%), Positives = 23/52 (44%), Gaps = 1/52 (1%)

Query: 54 KQKEQALVDQQKDQTKKLLKRNENLERKLAEAKGKDD-KETIAMLMAHIHEL 104
K K L + + K+++ L L + + KD K +L A+I+ L
Sbjct: 298 KSKSSDLQKIVMNNINRCTKKDKILNNTLKKCEDKDIFKLYGELLTANIYAL 349


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1901HTHFIS482e-08 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 47.9 bits (114), Expect = 2e-08
Identities = 21/130 (16%), Positives = 49/130 (37%), Gaps = 18/130 (13%)

Query: 180 MLGRKVLIVDDSATARRQVRETLEQLGLEVVEATDGLMALNQLKRWCDEGKVITDHILML 239
M G +L+ DD A R + + L + G +V ++ + ++
Sbjct: 1 MTGATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAA---------GDGDLV 51

Query: 240 ITDAEMPEMDGYKLTHEIRS-DKRMSDLFITLNTSLSGSFNNAMVE--KVGCDRFISK-F 295
+TD MP+ + + L I+ + L ++ + ++ + G ++ K F
Sbjct: 52 VTDVVMPDENAFDLLPRIKKARPDLPVLVMSAQNTF-----MTAIKASEKGAYDYLPKPF 106

Query: 296 QPDLLVEVVQ 305
L+ ++
Sbjct: 107 DLTELIGIIG 116


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1912TCRTETB446e-07 Tetracycline resistance protein TetB signature.
		>TCRTETB#Tetracycline resistance protein TetB signature.

Length = 458

Score = 44.5 bits (105), Expect = 6e-07
Identities = 58/304 (19%), Positives = 112/304 (36%), Gaps = 23/304 (7%)

Query: 43 AMATLAASFNTDITLVQQSLSLYLGGYALGMLCFGPLADRFGRKRLVLMGLTGFMLCSLA 102
++ +A FN + ++ +++G +G L+D+ G KRL+L G+ S+
Sbjct: 36 SLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSVI 95

Query: 103 LAFVTTIEAFLSI--RFLQAFIGAAA-----TVVVPGYIKELYGKNTAKGMSYVSLIMML 155
FV L I RF+Q GAAA VVV YI + +N K + I+ +
Sbjct: 96 -GFVGHSFFSLLIMARFIQG-AGAAAFPALVMVVVARYIPK---ENRGKAFGLIGSIVAM 150

Query: 156 APLIAPSIGSLILELGDWHLIFFILAFYAFILLLLVGLKLKMPSDIDKSSRSTQSFFGAY 215
+ P+IG +I W + I + L+ L K
Sbjct: 151 GEGVGPAIGGMIAHYIHWSYLLLIPMITIITVPFLMKLLKKEVRIKGHFDIKGIILMSVG 210

Query: 216 ATVFTKKGVKLNIASGVLTSFAFFCYL-----TASPFVYMEVFGLDKSLFAILFSTNVGA 270
F +I+ +++ +F ++ PFV + + G
Sbjct: 211 IVFFMLFTTSYSISFLIVSVLSFLIFVKHIRKVTDPFVDPGLG----KNIPFMIGVLCGG 266

Query: 271 LMLANVVNSKIVGRYGSKRMLKVSTFFGVIAGIALLSVNLLGLSYHFTVIMLLPLMACLG 330
++ V + Y K + ++ST I + + + + + + +L+ L
Sbjct: 267 IIFGTVAGFVSMVPYMMKDVHQLSTA--EIGSVIIFPGTMSVIIFGYIGGILVDRRGPLY 324

Query: 331 VMSV 334
V+++
Sbjct: 325 VLNI 328


24Spea_1930Spea_1946Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_1930-117-3.545079paraquat-inducible protein A
Spea_1931017-3.796892paraquat-inducible protein A
Spea_1932018-3.889081hypothetical protein
Spea_1933017-2.953979putative GAF sensor protein
Spea_1934-116-2.587658putative solute/DNA competence effector
Spea_1935016-2.792904carboxy-terminal protease
Spea_1936014-2.632770aminopeptidase N
Spea_1937016-2.349960hypothetical protein
Spea_1938017-2.589329hypothetical protein
Spea_1939018-3.114203hypothetical protein
Spea_1940019-3.585070BNR repeat-containing protein
Spea_1941018-3.484194hypothetical protein
Spea_1942019-3.825861NAD-glutamate dehydrogenase
Spea_1943-119-4.030347dihydroorotate dehydrogenase 2
Spea_1944017-3.783034hypothetical protein
Spea_1945117-3.564105cyclophilin type peptidyl-prolyl cis-trans
Spea_1946117-3.171494****23S rRNA m(2)G2445 methyltransferase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1941ACRIFLAVINRP703e-14 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 69.9 bits (171), Expect = 3e-14
Identities = 34/206 (16%), Positives = 84/206 (40%), Gaps = 9/206 (4%)

Query: 566 ETIELVIDKVNKLQKELDNDKIQFKLASGPVGVMAATNEAVAEAQLPMMLYVYGAVFILC 625
+T + + K+ +LQ ++ + + V + + VF++
Sbjct: 301 DTAKAIKAKLAELQPFFPQG-MKVLYPYDTTPFVQLSIHEVVKT----LFEAIMLVFLVM 355

Query: 626 LISFRSLRATIAVILPLYVVSTLAQALMTQLDIGLAVSTLPVIALGVGIGVDYGIYILST 685
+ +++RAT+ + + VV A++ + T+ + L +G+ VD I ++
Sbjct: 356 YLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVEN 415

Query: 686 MA-VRLRDGMPVQKAYYEALVERGSAVIFTGLTLAIGVSTWFF---SALKFQMDMGILLT 741
+ V + D +P ++A +++ + A++ + L+ F S I +
Sbjct: 416 VERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIV 475

Query: 742 FMFLVNMLGAIIILPAIAAMFWRQPK 767
+++L A+I+ PA+ A +
Sbjct: 476 SAMALSVLVALILTPALCATLLKPVS 501



Score = 44.8 bits (106), Expect = 1e-06
Identities = 26/146 (17%), Positives = 65/146 (44%), Gaps = 4/146 (2%)

Query: 233 LIAILVTAVMVYFFSKSVALTILPLVCSLIAVVWQLGLLTVIGFGLDPMSILIPFLVFAI 292
AI++ +++Y F +++ T++P + + ++ +L G+ ++ +++ L +
Sbjct: 345 FEAIMLVFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGL 404

Query: 293 GVSHSVQMI-NAVRRRVTDGQTTKAAAALAFRSLLIPGGVALLSDTIGFMTLLAID--IG 349
V ++ ++ N R + D K A + + + + F+ + G
Sbjct: 405 LVDDAIVVVENVERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTG 464

Query: 350 II-RELAISASLGVAVIILTNLILLP 374
I R+ +I+ +A+ +L LIL P
Sbjct: 465 AIYRQFSITIVSAMALSVLVALILTP 490



Score = 37.5 bits (87), Expect = 2e-04
Identities = 31/151 (20%), Positives = 58/151 (38%), Gaps = 8/151 (5%)

Query: 620 AVFILCLISFRSLRATIAVIL--PLYVVSTLAQALMTQLDIGLAVSTLPVIALGVGIGVD 677
VF+ + S ++V+L PL +V L A + + + ++ +G+
Sbjct: 882 VVFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVY-FMVGLLTT-IGLSAK 939

Query: 678 YGIYILS-TMAVRLRDGMPVQKAYYEALVERGSAVIFTGLTLAIGVSTWFFSA---LKFQ 733
I I+ + ++G V +A A+ R ++ T L +GV S Q
Sbjct: 940 NAILIVEFAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQ 999

Query: 734 MDMGILLTFMFLVNMLGAIIILPAIAAMFWR 764
+GI + + L AI +P + R
Sbjct: 1000 NAVGIGVMGGMVSATLLAIFFVPVFFVVIRR 1030


25Spea_2002Spea_2019Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_2002-116-3.371352GreA/GreB family elongation factor
Spea_2003-118-3.906462hypothetical protein
Spea_2004019-4.469515XRE family transcriptional regulator
Spea_2005022-6.125757malate synthase
Spea_2006223-5.958154Fmu (Sun) domain-containing protein
Spea_2007326-6.814534sulfatase
Spea_2008429-6.163947peptidoglycan-binding domain-containing protein
Spea_2009430-5.833126transposase and inactivated derivative
Spea_2010330-5.384725peptidase A24A prepilin type IV
Spea_2011429-5.227471ATPase AAA
Spea_2012331-5.414995SAF domain-containing protein
Spea_2013232-6.425779type II and III secretion system protein
Spea_2014330-6.043149hypothetical protein
Spea_2015228-5.757614hypothetical protein
Spea_2016328-5.797255TadE family protein
Spea_2017328-5.360181TadE family protein
Spea_2018327-5.079133Flp pilus assembly protein ATPase CpaE-like
Spea_2019223-3.368747type II secretion system protein E
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2010PREPILNPTASE290.008 Type IV prepilin cysteine protease (C20) family sig...
		>PREPILNPTASE#Type IV prepilin cysteine protease (C20) family

signature.
Length = 290

Score = 29.4 bits (66), Expect = 0.008
Identities = 37/186 (19%), Positives = 70/186 (37%), Gaps = 40/186 (21%)

Query: 5 QLLFQVVTAGVFFVLAITFDLVREKIPNWLCLIAIFCGFLIN---SYFAQLNGLMLSFIG 61
L ++ V L DL + +P+ L L ++ G L N + + + ++ + G
Sbjct: 133 GTLAALLLTWVLVALTFI-DLDKMLLPDQLTLPLLWGGLLFNLLGGFVSLGDAVIGAMAG 191

Query: 62 FSLAFIILFPTFMFKI------LGAGDIKLMMGIGALIGPQLLVWSIAYAIIAGAITSLL 115
+ + + + + FK+ +G GD KL+ +GA +G Q L + + + GA +
Sbjct: 192 YLVLWSL---YWAFKLLTGKEGMGYGDFKLLAALGAWLGWQALPIVLLLSSLVGAFMGIG 248

Query: 116 LVIWKSGLSGCFKTVRRYWDCFYLRTYFKPEEGEAAGQRVPYAPALAIGWLWACSLNPDI 175
L++ + + +P+ P LAI A I
Sbjct: 249 LILLR---------------------------NHHQSKPIPFGPYLAIAGWIALLWGDSI 281

Query: 176 TYLYST 181
T Y T
Sbjct: 282 TRWYLT 287


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2011HTHFIS300.018 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 30.2 bits (68), Expect = 0.018
Identities = 9/34 (26%), Positives = 17/34 (50%)

Query: 159 KDLLFKIGPAMNSSRPVLIYGPPGTGKSYLCRHL 192
+++ + M + ++I G GTGK + R L
Sbjct: 147 QEIYRVLARLMQTDLTLMITGESGTGKELVARAL 180


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2013BCTERIALGSPD1451e-39 Bacterial general secretion pathway protein D signa...
		>BCTERIALGSPD#Bacterial general secretion pathway protein D

signature.
Length = 660

Score = 145 bits (367), Expect = 1e-39
Identities = 58/256 (22%), Positives = 113/256 (44%), Gaps = 23/256 (8%)

Query: 176 QVMLEVVVAEVQRNVARQFDSKFFI--------FNQGSNLSGGLVGGGGGFDPGSIGG-- 225
QV++E ++AEVQ ++ N G +S + G G++
Sbjct: 346 QVLVEAIIAEVQDADGLNLGIQWANKNAGMTQFTNSGLPISTAIAGANQYNKDGTVSSSL 405

Query: 226 IDAKGLFAQYINGDLMMNFALDIA--KQNGLAKVLAEPNVTAMSGQSAEFLSGGEFPIPV 283
A F G N+A+ + + +LA P++ + A F G E P+
Sbjct: 406 ASALSSFNGIAAGFYQGNWAMLLTALSSSTKNDILATPSIVTLDNMEATFNVGQEVPVLT 465

Query: 284 P-----GENGNTTIEYRDYGVGVKFVPTVLDSGQINLNLNVVVSEISTANGFAISGNTST 338
G+N T+E + G+ +K P + + + L + VS ++ A +++
Sbjct: 466 GSQTTSGDNIFNTVERKTVGIKLKVKPQINEGDSVLLEIEQEVSSVADAAS------STS 519

Query: 339 TLVVPSLVKRSTATTVELADGQTIAISGLISDTLRENIDKLPGLGDVPVLGQLFTSKSFQ 398
+ + + R+ V + G+T+ + GL+ ++ + DK+P LGD+PV+G LF S S +
Sbjct: 520 SDLGATFNTRTVNNAVLVGSGETVVVGGLLDKSVSDTADKVPLLGDIPVIGALFRSTSKK 579

Query: 399 SGQSELVILVTPRLVR 414
+ L++ + P ++R
Sbjct: 580 VSKRNLMLFIRPTVIR 595


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2019HTHFIS290.043 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 29.0 bits (65), Expect = 0.043
Identities = 11/59 (18%), Positives = 27/59 (45%)

Query: 170 ALDGPSLSIRRFAVDKLNAGQLIEIGSVTEAMIELLKGGVKGKLNILVSGGTGSGKTTL 228
AL P + D + L+ + + + +L ++ L ++++G +G+GK +
Sbjct: 118 ALAEPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELV 176


26Spea_2045Spea_2113Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_2045-214-3.083594hypothetical protein
Spea_2046-114-2.643913deoxyguanosinetriphosphate
Spea_2047015-3.159235hypothetical protein
Spea_2048016-3.115416aminotransferase AlaT
Spea_2049117-3.023789elongation factor P
Spea_2050114-3.009713hypothetical protein
Spea_2051-114-1.758908flavodoxin FldA
Spea_2052018-2.514892LexA regulated protein
Spea_2053-119-2.979367hypothetical protein
Spea_2054-123-3.997382alpha/beta hydrolase fold protein
Spea_2055-223-5.623073replication initiation regulator SeqA
Spea_2056025-7.740174phosphoglucomutase
Spea_2057128-9.184238hypothetical protein
Spea_2058123-8.457746hypothetical protein
Spea_2059118-6.745460hypothetical protein
Spea_2060115-5.716313hypothetical protein
Spea_2061-114-4.937673hypothetical protein
Spea_2062222-1.561614ferredoxin
Spea_2063219-1.755461ribonucleotide-diphosphate reductase subunit
Spea_2064115-1.152353ribonucleotide-diphosphate reductase subunit
Spea_2065013-0.569975HAD family hydrolase
Spea_2066114-0.9814093-demethylubiquinone-9 3-methyltransferase
Spea_2067115-0.906965DNA gyrase subunit A
Spea_2068017-1.008438beta-lactamase
Spea_2069121-0.639093phosphoserine aminotransferase
Spea_2070225-1.106579aromatic amino acid aminotransferase
Spea_2071224-1.6660543-phosphoshikimate 1-carboxyvinyltransferase
Spea_2072330-1.548093cytidylate kinase
Spea_2073228-1.19091330S ribosomal protein S1
Spea_2074116-1.848388integration host factor subunit beta
Spea_2075016-3.267698hypothetical protein
Spea_2076014-2.274798hypothetical protein
Spea_2077-114-2.647891orotidine 5'-phosphate decarboxylase
Spea_2078-114-2.958060short chain dehydrogenase
Spea_2079-115-3.603910hypothetical protein
Spea_2080-114-3.369888magnesium and cobalt transport protein CorA
Spea_2081-113-2.230520acyl-CoA dehydrogenase domain-containing
Spea_2082117-2.926381D-alanyl-D-alanine
Spea_2083016-2.246866hypothetical protein
Spea_2084014-2.041555hypothetical protein
Spea_2085-114-3.293581phosphatidylserine synthase
Spea_2086-212-3.414370DTW domain-containing protein
Spea_2087-314-3.843297hypothetical protein
Spea_2088-315-4.097140two component LuxR family transcriptional
Spea_2089-115-4.311532histidine kinase
Spea_2090017-5.170504ApbE family lipoprotein
Spea_2091016-4.461012FMN-binding domain-containing protein
Spea_2092119-4.166020porin
Spea_2093321-4.737928pseudouridine synthase
Spea_2094316-4.325639integrase family protein
Spea_2095117-4.364281hypothetical protein
Spea_2096015-3.839954hypothetical protein
Spea_2097115-3.667464hypothetical protein
Spea_2098215-4.218265putative orphan protein
Spea_2099217-3.586232putative Zn-dependent aminopeptidase
Spea_2100121-3.657554short-chain dehydrogenase/reductase SDR
Spea_2101324-3.233397alpha-L-glutamate ligase
Spea_2102322-3.451447hypothetical protein
Spea_2103323-3.582412hypothetical protein
Spea_2104224-3.067524glyceraldehyde-3-phosphate dehydrogenase
Spea_2105221-3.016588hypothetical protein
Spea_2106223-2.582459glyceraldehyde-3-phosphate dehydrogenase
Spea_2107-117-2.194945*******DsrC family protein
Spea_2108017-3.060063DsrH family protein
Spea_2109018-2.170900DsrE family protein
Spea_2110115-1.815245DsrE family protein
Spea_2111015-1.294202hypothetical protein
Spea_2112016-1.084633putative DNA-binding transcriptional regulator
Spea_2113217-1.103683inner membrane transport protein YdhC
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2055TETREPRESSOR270.039 Tetracycline repressor protein signature.
		>TETREPRESSOR#Tetracycline repressor protein signature.

Length = 218

Score = 27.2 bits (60), Expect = 0.039
Identities = 18/82 (21%), Positives = 30/82 (36%), Gaps = 10/82 (12%)

Query: 60 VVQAAPEEISHPSLEESSPKPIKVTKLAAKPVSDFSNLI-DADALAAQKGAVGRFLFILD 118
+ A E+ H + P P + L+ +A + FL L+
Sbjct: 141 TLGAVLEQQEHTAALTDRPAA---------PDENLPPLLREALQIMDSDDGEQAFLHGLE 191

Query: 119 TVYRASTKQFEQVLQIQGRDRL 140
++ R Q +LQI G D+L
Sbjct: 192 SLIRGFEVQLTALLQIVGGDKL 213


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2074DNABINDINGHU1143e-37 Prokaryotic integration host factor signature.
		>DNABINDINGHU#Prokaryotic integration host factor signature.

Length = 91

Score = 114 bits (287), Expect = 3e-37
Identities = 32/89 (35%), Positives = 56/89 (62%), Gaps = 1/89 (1%)

Query: 2 TKSELIEKLATRQSQLSAKEVEAAIKEMLEQMADTLETGDRIEIRGFGSFSLHYRAPRTG 61
K +LI K+A ++L+ K+ AA+ + ++ L G+++++ GFG+F + RA R G
Sbjct: 3 NKQDLIAKVA-EATELTKKDSAAAVDAVFSAVSSYLAKGEKVQLIGFGNFEVRERAARKG 61

Query: 62 RNPKTGTSVELEGKYVPHFKPGKELRERV 90
RNP+TG ++++ VP FK GK L++ V
Sbjct: 62 RNPQTGEEIKIKASKVPAFKAGKALKDAV 90


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2078DHBDHDRGNASE1061e-29 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase sig...
		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

signature.
Length = 261

Score = 106 bits (265), Expect = 1e-29
Identities = 78/257 (30%), Positives = 115/257 (44%), Gaps = 12/257 (4%)

Query: 5 QGKNVVVVGGTSGINLAIAVHFSQAGANVAVASRSVEKVDAAVELLKQANPNGEHLGVCF 64
+GK + G GI A+A + GA++A + EK++ V LK + E
Sbjct: 7 EGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPA-- 64

Query: 65 DVRDLEALSKGFATISDAFSTIDVLVSGAAGNFPSTAEKLSENGFKSVMDIDLLGSFQVL 124
DVRD A+ + A I ID+LV+ A P LS+ +++ ++ G F
Sbjct: 65 DVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNAS 124

Query: 125 KQAYPLMSDT-GGAIIQISAPQAFVPMPMQVHVCAAKAGVDMLTKTLAIEWGRKGIRINS 183
+ M D G+I+ + + A VP ++KA M TK L +E IR N
Sbjct: 125 RSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNI 184

Query: 184 IVPGPIAGTEGFNRLAPSEELQAHVAQG--------VPLKRNGRCEDIANAALFLASDMA 235
+ PG T+ L E V +G +PLK+ + DIA+A LFL S A
Sbjct: 185 VSPGS-TETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQA 243

Query: 236 SYITGTVLPVDGGWSLG 252
+IT L VDGG +LG
Sbjct: 244 GHITMHNLCVDGGATLG 260


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2088HTHFIS962e-25 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 95.7 bits (238), Expect = 2e-25
Identities = 33/148 (22%), Positives = 66/148 (44%)

Query: 4 LYLVDDDQAVLDSLTWMLNGLGFQPQGFLSADSFLNQVNLHNEGIAVLDVQMPGMDGSAL 63
+ + DDD A+ L L+ G+ + +A + + + + V DV MP + L
Sbjct: 6 ILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFDL 65

Query: 64 LSLLTKAQSPIAVIMLSGHGNIAMAVQAIQRGALDFLEKPVDGDKLVVLLEQAKTQTKLN 123
L + KA+ + V+++S A++A ++GA D+L KP D +L+ ++ +A + K
Sbjct: 66 LPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKRR 125

Query: 124 MQRKLAREALSDKLEALTPREHEVMEKV 151
+ L + E+ +
Sbjct: 126 PSKLEDDSQDGMPLVGRSAAMQEIYRVL 153


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2092ECOLNEIPORIN595e-12 E.coli/Neisseria porin superfamily signature.
		>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature.

Length = 331

Score = 59.4 bits (144), Expect = 5e-12
Identities = 68/353 (19%), Positives = 113/353 (32%), Gaps = 30/353 (8%)

Query: 2 MKTIKLTLLAAAVLASPSVMADAYKFYGRIDYSVTHSDS----GSATHSGKSGTILENNW 57
MK + L AA+ + YG I V S S G+ S ++GT + +
Sbjct: 1 MKKSLIALTLAALPVAAMADVT---LYGTIKAGVETSRSVAHNGAQAASVETGTGIVDLG 57

Query: 58 SRLGVKGDAALNEEFTVFYQIEVGVNGASEGKSNNPFSARPTFLGIKHSTAGQLAAGRID 117
S++G KG L +Q+E + A +++ + R +F+G+K G+L GR++
Sbjct: 58 SKIGFKGQEDLGNGLKAIWQVEQKASIAG---TDSGWGNRQSFIGLK-GGFGKLRVGRLN 113

Query: 118 PVFKMAKGTADAMDMYSLKHDRLFAGDKRWGDSLEYKTVKWNKLQFGASYILEDNYYDED 177
V K A + S+ Y + ++ L Y L DN
Sbjct: 114 SVLKDTGDINPWDSKSDYLGVNKIAEPEARLISVRYDSPEFAGLSGSVQYALNDN----- 168

Query: 178 DVRRDNGN-YQVALTYGDKLFKTGDLYLAAAYTDGVEDIKGFRAVAQYKIDKLMLGTIYQ 236
R N Y Y + F + E++ + + +Y
Sbjct: 169 -AGRHNSESYHAGFNYKNGGFFVQYGGAYKRHHQVQENVNIEKYQIHRLVSGYDNDALYA 227

Query: 237 SSEIVNPNLDNWQQRDGDG--FIVSAKYQIDKLTLKAQYGQDDSGTGKIAGRVYSQLGAA 294
S + + ++ V+A + + G Y+
Sbjct: 228 SVAVQQQDAKLVEENYSHNSQTEVAATLAYRFGNVTPRVSYAHGFKGSFDATNYNND--- 284

Query: 295 ATEVPEVSQWAIGAEYRLSKSTRVHTEIGQFDVKQYSD-FDDTIASVGFRIDF 346
Q +GAEY SK T G + F T VG R F
Sbjct: 285 ------YDQVVVGAEYDFSKRTSALVSAGWLQEGKGESKFVSTAGGVGLRHKF 331


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2094PF05272310.012 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 30.8 bits (69), Expect = 0.012
Identities = 11/52 (21%), Positives = 20/52 (38%), Gaps = 5/52 (9%)

Query: 228 LRDKAILQLGLQGGFRRSELAEVRIEHISFL-REKLKVRVPYSKSNQQGQRE 278
+ +L FRR++ V+ +F K + R Y + Q R+
Sbjct: 639 IAGIVAYELSEMTAFRRADAEAVK----AFFSSRKDRYRGAYGRYVQDHPRQ 686


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2097ECOLNEIPORIN260.035 E.coli/Neisseria porin superfamily signature.
		>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature.

Length = 331

Score = 26.3 bits (58), Expect = 0.035
Identities = 38/126 (30%), Positives = 51/126 (40%), Gaps = 18/126 (14%)

Query: 1 MRRHILTLGLLLLPVSAMANIIV---DKTGVDEKDYVYDLHQCTEMSTQVEQKQTEGSAI 57
M++ ++ L L LPV+AMA++ + K GV+ V GS I
Sbjct: 1 MKKSLIALTLAALPVAAMADVTLYGTIKAGVETSRSVAHNGAQAASVETGTGIVDLGSKI 60

Query: 58 GTAAKGAA-IGSAGKAI---------AGGSGSEGAKQGAAIGL--GVGVLSKGRERRNNK 105
G KG +G+ KAI AG G +Q + IGL G G L GR K
Sbjct: 61 GF--KGQEDLGNGLKAIWQVEQKASIAGTDSGWGNRQ-SFIGLKGGFGKLRVGRLNSVLK 117

Query: 106 DTYAAE 111
DT
Sbjct: 118 DTGDIN 123


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2100DHBDHDRGNASE702e-16 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase sig...
		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

signature.
Length = 261

Score = 69.7 bits (170), Expect = 2e-16
Identities = 49/191 (25%), Positives = 79/191 (41%), Gaps = 8/191 (4%)

Query: 3 KHALITGGNRGIGRAFVEHYLKAGWNVTAC-CRDPKRAVELSVLKSDYEQLKVMSLDVSL 61
K A ITG +GIG A G ++ A K +S LK++ + DV
Sbjct: 9 KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVRD 68

Query: 62 SESIAILTKELAG--TPIDLLINNAGYYGPKGVEFGSCDAKEWGKVIEVNTIAPLMLTEA 119
S +I +T + PID+L+N AG P + S +EW VN+ + +
Sbjct: 69 SAAIDEITARIEREMGPIDILVNVAGVLRPGLIH--SLSDEEWEATFSVNSTGVFNASRS 126

Query: 120 LYQNLKLVGNPVVAFISSKVGSMEDNTSGGGYYYRSSKAALNSVVKSLSIDLKDDGIKCV 179
+ + + + + + S + + Y SSKAA K L ++L + I+C
Sbjct: 127 VSKYMMDRRSGSIVTVGSNPAGVPRTSMAA---YASSKAAAVMFTKCLGLELAEYNIRCN 183

Query: 180 ALHPGWVLTAM 190
+ PG T M
Sbjct: 184 IVSPGSTETDM 194


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2113TCRTETB605e-12 Tetracycline resistance protein TetB signature.
		>TCRTETB#Tetracycline resistance protein TetB signature.

Length = 458

Score = 60.3 bits (146), Expect = 5e-12
Identities = 37/194 (19%), Positives = 77/194 (39%), Gaps = 2/194 (1%)

Query: 3 SLTSVKYYIFLAYLAVLSMLGFIATDMYLPAFKAIEDTMATSPSQVAMSLTFFLAGLALG 62
S +++++ L +L +LS + + + I + P+ T F+ ++G
Sbjct: 6 SQSNLRHNQILIWLCILSFFSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIG 65

Query: 63 QLLYGPLVERFGKRNSLILGLVLFAAASFSISVSDSILVFNI-SRFIQALGACSAGVIWQ 121
+YG L ++ G + L+ G+++ S V S I +RFIQ GA + +
Sbjct: 66 TAVYGKLSDQLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVM 125

Query: 122 AIVIEKYDAAKAQGVFSNIMPLVALSPALAPILGAFILQSLGWQSIFITLTGMAAVMILL 181
+V F I +VA+ + P +G I + W + + + + +
Sbjct: 126 VVVARYIPKENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYIHWSYLLLIPM-ITIITVPF 184

Query: 182 TVWFVPAETKAISH 195
+ + E + H
Sbjct: 185 LMKLLKKEVRIKGH 198


27Spea_2146Spea_2171Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_21462180.321219NADH:flavin oxidoreductase
Spea_2147119-0.248618alpha/beta hydrolase fold protein
Spea_21482170.053407short-chain dehydrogenase/reductase SDR
Spea_2149217-0.046531hypothetical protein
Spea_21502160.101924long-chain-acyl-CoA synthetase
Spea_21513160.932856nonspecific lipid-transfer protein
Spea_21522170.413061hypothetical protein
Spea_21533170.961247glyoxalase/bleomycin resistance
Spea_21543181.030173coenzyme A transferase
Spea_21553171.030837coenzyme A transferase
Spea_21564201.277962enoyl-CoA hydratase
Spea_21573221.5783732-nitropropane dioxygenase
Spea_21583211.930657enoyl-CoA hydratase
Spea_21592230.839542acyl-CoA dehydrogenase domain-containing
Spea_2160122-0.069609acyl-CoA dehydrogenase domain-containing
Spea_2161022-0.387971acetyl-CoA acetyltransferase
Spea_2162220-0.895476short chain dehydrogenase
Spea_2163120-1.098814amidase
Spea_2164120-1.939884hypothetical protein
Spea_2165119-0.260209hypothetical protein
Spea_21661180.341379hypothetical protein
Spea_21672180.447209hypothetical protein
Spea_21683200.424130short chain dehydrogenase
Spea_2169220-0.289083dehydratase
Spea_2170321-0.488852acetyl-CoA acetyltransferase
Spea_2171321-1.338204enoyl-CoA hydratase/isomerase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2146FERRIBNDNGPP310.015 Ferrichrome-binding periplasmic protein signature.
		>FERRIBNDNGPP#Ferrichrome-binding periplasmic protein signature.

Length = 296

Score = 31.1 bits (70), Expect = 0.015
Identities = 11/32 (34%), Positives = 22/32 (68%)

Query: 465 LKQSKVDIRLNTEASVELLSQLQPDEILLAVG 496
L S +D+ L TE ++ELL++++P ++ + G
Sbjct: 74 LPDSVIDVGLRTEPNLELLTEMKPSFMVWSAG 105


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2148DHBDHDRGNASE1421e-43 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase sig...
		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

signature.
Length = 261

Score = 142 bits (358), Expect = 1e-43
Identities = 77/252 (30%), Positives = 119/252 (47%), Gaps = 18/252 (7%)

Query: 6 KVIFVTGAGQGMGLAMVKLFAEQGAKVAAIDINEAAAKKVAEQQSAESGTEVIGIGCDIS 65
K+ F+TGA QG+G A+ + A QGA +AA+D N +KV AE+ D+
Sbjct: 9 KIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAE-AFPADVR 67

Query: 66 QSSSVRDAITEVVQRLGSIDVVINNAGIGSIDSFIDTPDENWHKVINVNLTGTFYCCREA 125
S+++ + + + +G ID+++N AG+ DE W +VN TG F R
Sbjct: 68 DSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRSV 127

Query: 126 ARVMKEQGSGCIINISSTAVMSGD-GPSHYCASKAGVIGLTRSIAKELAASGIRVNTIVP 184
++ M ++ SG I+ + S + Y +SKA + T+ + ELA IR N + P
Sbjct: 128 SKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSP 187

Query: 185 GPTNTPMMADIPEEWTQQMIDA-------------IPLGRMGEPADIAKLASFIASDDAS 231
G T T M + W + IPL ++ +P+DIA F+ S A
Sbjct: 188 GSTETDMQWSL---WADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQAG 244

Query: 232 FITGQNLAVNGG 243
IT NL V+GG
Sbjct: 245 HITMHNLCVDGG 256


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2162DHBDHDRGNASE681e-15 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase sig...
		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

signature.
Length = 261

Score = 68.2 bits (166), Expect = 1e-15
Identities = 61/259 (23%), Positives = 100/259 (38%), Gaps = 19/259 (7%)

Query: 2 KACNSRTVIITGSGGGLGRAYALALAAEGANVVVNDIRADAAAAVVDEILTQGGQAIANS 61
K + ITG+ G+G A A LA++GA++ D + VV + + A A
Sbjct: 4 KGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFP 63

Query: 62 DDITRMDTATNIVDAALEAFGEVHVLINNAGVLADRMFISLSEADWDKVMQVHLKGHFCL 121
D+ I G + +L+N AGVL + SLS+ +W+ V+ G F
Sbjct: 64 ADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNA 123

Query: 122 ANILGRRWRDLAKAGQPVDARIINTSSGAGLQGSIGQSNYSAAKGGIASLTLVQAAELGR 181
+ + + D I+ S + Y+++K T EL
Sbjct: 124 SRSVSKYMMDRRSGS------IVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAE 177

Query: 182 YGVTVNALAPAA-RTSMTQSAMPD-----VVKKPEDGSFDLW-------APENVAPLVVW 228
Y + N ++P + T M S D V K +F P ++A V++
Sbjct: 178 YNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLF 237

Query: 229 LSSSESKHISGQILESQGG 247
L S ++ HI+ L GG
Sbjct: 238 LVSGQAGHITMHNLCVDGG 256


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2168DHBDHDRGNASE944e-25 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase sig...
		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

signature.
Length = 261

Score = 94.0 bits (233), Expect = 4e-25
Identities = 68/245 (27%), Positives = 113/245 (46%), Gaps = 13/245 (5%)

Query: 14 LKGKSVLITAAAGAGIGFAAARRAAEEGCRALMISDIHPRRLDEAVTRLRAETGLEQVYG 73
++GK IT AA GIG A AR A +G + D +P +L++ V+ L+AE + +
Sbjct: 6 IEGKIAFITGAA-QGIGEAVARTLASQGAH-IAAVDYNPEKLEKVVSSLKAEARHAEAFP 63

Query: 74 QICDVTNQQDVSTLVQLAESKLAGIDVLINNAGLGGQKNVVDMSDNEWSTVLDITLTGTF 133
DV + + + E ++ ID+L+N AG+ + +SD EW + TG F
Sbjct: 64 --ADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVF 121

Query: 134 RMIREILPHMQARGHGVIVNNASVLGWRAQKEQAHYAAAKAGVMALTRCSALEAAEHGVR 193
R + +M R G IV S + A YA++KA + T+C LE AE+ +R
Sbjct: 122 NASRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIR 181

Query: 194 INAVSPSIALHDFLKKASSEE---------LLNQLASKEAFGRAAEVWEVANVMMFLASD 244
N VSP D ++E L + + A+ ++A+ ++FL S
Sbjct: 182 CNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSG 241

Query: 245 YSSYM 249
+ ++
Sbjct: 242 QAGHI 246


28Spea_2195Spea_2214Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_2195-216-3.251774DNA-directed DNA polymerase
Spea_2196-216-4.258931peptidase S24/S26 domain-containing protein
Spea_2197-216-4.890625diguanylate cyclase
Spea_2198-117-2.543482AraC family transcriptional regulator
Spea_2199-218-3.255996hypothetical protein
Spea_2200018-2.666986hypothetical protein
Spea_2201119-2.669697hypothetical protein
Spea_2202221-4.165120hypothetical protein
Spea_2203122-4.026330hypothetical protein
Spea_2204121-4.076673trimethyllysine dioxygenase
Spea_2205023-5.167105threonine aldolase
Spea_2206019-4.979791amino acid permease-associated protein
Spea_2207-120-5.663517hypothetical protein
Spea_2208-120-4.277773N-acetyltransferase GCN5
Spea_2209018-2.868459hypothetical protein
Spea_2210017-1.987791hypothetical protein
Spea_2211118-0.625149integrase family protein
Spea_2212529-0.815248hypothetical protein
Spea_2213529-1.191817hypothetical protein
Spea_22142180.176928cbb3-type cytochrome c oxidase subunit I
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2208SACTRNSFRASE402e-06 Streptothricin acetyltransferase signature.
		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

Length = 173

Score = 39.5 bits (92), Expect = 2e-06
Identities = 19/89 (21%), Positives = 38/89 (42%), Gaps = 5/89 (5%)

Query: 67 LWLAFDDNKKIVGHIDIRGHAENHTKHRVLLGMGVDRSVRRFGIGKQLINQMLEWVADEP 126
+L + +N +G I IR N + ++ + V + R+ G+G L+++ +EW +
Sbjct: 67 AFLYYLENN-CIGRIKIR---SNWNGYALIEDIAVAKDYRKKGVGTALLHKAIEWAKENH 122

Query: 127 LIEFIDLWVLSNNLAAQKLYISTGFQKCG 155
+ L N++A Y F
Sbjct: 123 FCG-LMLETQDINISACHFYAKHHFIIGA 150


29Spea_2257Spea_2277Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_2257225-2.114162peptidase M14 carboxypeptidase A
Spea_2258428-2.141883thioredoxin reductase
Spea_2259528-3.000650N-acetyltransferase GCN5
Spea_2260327-1.74253650S ribosomal protein L20
Spea_2261224-1.58707750S ribosomal protein L35
Spea_2262223-1.673760translation initiation factor IF-3
Spea_2263016-1.271869threonyl-tRNA synthetase
Spea_2264115-1.291961hypothetical protein
Spea_2265214-0.686576short-chain dehydrogenase/reductase SDR
Spea_2266414-2.848388hypothetical protein
Spea_2267414-0.888134riboflavin synthase subunit alpha
Spea_2268316-1.271869MATE efflux family protein
Spea_2269318-2.234360transposase
Spea_2270320-3.755102PEBP family protein
Spea_2271114-2.520792hypothetical protein
Spea_2272015-2.714105pentapeptide repeat-containing protein
Spea_2273116-4.741189hypothetical protein
Spea_2274014-3.933247N-acetyltransferase GCN5
Spea_2275113-3.389622hypothetical protein
Spea_2276012-2.206962radical SAM domain-containing protein
Spea_2277016-4.010989peptidase S15
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2265DHBDHDRGNASE841e-21 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase sig...
		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

signature.
Length = 261

Score = 84.3 bits (208), Expect = 1e-21
Identities = 71/248 (28%), Positives = 109/248 (43%), Gaps = 18/248 (7%)

Query: 5 ALVTGAAKRIGLAIATQLHDDGYNVVLHYGQSIDDAQALCDTLNTKRADSAIIMQADLAN 64
A +TGAA+ IG A+A L G ++ + + A A AD+ +
Sbjct: 11 AFITGAAQGIGEAVARTLASQGAHIAA--VDYNPEKLEKVVSSLKAEARHAEAFPADVRD 68

Query: 65 SDAIDTLIAKINSAGIRLSVLINNASCFYPTPIGETSFIKAQQLLATNLIAPYLLAEKLS 124
S AID + A+I + +L+N A P I S + + + N + + +S
Sbjct: 69 SAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRSVS 128

Query: 125 PLLEA-NNGCVINLLDIHGRRPLKDHGLYSISKAALEMATLSLAQELAP-NIRVNGVSPG 182
+ +G ++ + P Y+ SKAA M T L ELA NIR N VSPG
Sbjct: 129 KYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVSPG 188

Query: 183 AI-------LWPEQSGEQ-----SQQAILSAIPLAKLGQVDDIARLISHLVS--APYISG 228
+ LW +++G + S + + IPL KL + DIA + LVS A +I+
Sbjct: 189 STETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQAGHITM 248

Query: 229 QVIAVDGG 236
+ VDGG
Sbjct: 249 HNLCVDGG 256


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2271TCRTETB371e-04 Tetracycline resistance protein TetB signature.
		>TCRTETB#Tetracycline resistance protein TetB signature.

Length = 458

Score = 37.2 bits (86), Expect = 1e-04
Identities = 40/218 (18%), Positives = 90/218 (41%), Gaps = 13/218 (5%)

Query: 4 RNRILLTWISFLSYALTGSLIIVTGIVMGDIAKFFNLPISSMSNTFTFLNTGVLISIFLN 63
R+ +L W+ LS+ + +V + + DIA FN P +S + T I +
Sbjct: 11 RHNQILIWLCILSF-FSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVY 69

Query: 64 VWLMEIIALKKQLIFGFILMVLAVLGLMFGHNLA-IFSASMFVLGVVSGITMSIGTYLIT 122
L + + +K+ L+FG I+ + GH+ + + F+ G + ++ ++
Sbjct: 70 GKLSDQLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVA 129

Query: 123 RLYHGKQCGSRLLFTDSFFSMAGMIFPLISAALLAHSVAWYWVYAAIGMIYVAIFILALV 182
R + G S +M + P I + + I Y+ + + +
Sbjct: 130 RYIPKENRGKAFGLIGSIVAMGEGVGPAIGGMIAHY----------IHWSYLLLIPMITI 179

Query: 183 CEFPVLIKSEEQQQAVKEKWGL-GILFLAIAALCYILG 219
P L+K +++ +K + + GI+ +++ + ++L
Sbjct: 180 ITVPFLMKLLKKEVRIKGHFDIKGIILMSVGIVFFMLF 217


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2272cloacin402e-05 Cloacin signature.
		>cloacin#Cloacin signature.

Length = 551

Score = 40.5 bits (94), Expect = 2e-05
Identities = 27/82 (32%), Positives = 30/82 (36%), Gaps = 2/82 (2%)

Query: 560 GNGGNGANDGKDGIGGQ--GGQGFLGANSEWVNGDPGVGSNGRGGNADDSFSASGGGGGG 617
G G G N G G GG LG +G N G S GGG G
Sbjct: 3 GGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGH 62

Query: 618 GGYGGGGAGDDGAGAGGGSWSV 639
G GG G G+G GG +V
Sbjct: 63 GNGGGNGNSGGGSGTGGNLSAV 84



Score = 35.8 bits (82), Expect = 6e-04
Identities = 24/81 (29%), Positives = 30/81 (37%), Gaps = 5/81 (6%)

Query: 552 DGGSTDEWGNGGNGANDGKDGIGGQGGQGFLGANSEWVNGDPGVGSNGRGGNADDSFSAS 611
+ G+ GN G G G G G+ N+ W G GS S +
Sbjct: 10 NTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPW-----GGGSGSGIHWGGGSGHGN 64

Query: 612 GGGGGGGGYGGGGAGDDGAGA 632
GGG G G G G G+ A A
Sbjct: 65 GGGNGNSGGGSGTGGNLSAVA 85


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2274SACTRNSFRASE523e-11 Streptothricin acetyltransferase signature.
		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

Length = 173

Score = 51.9 bits (124), Expect = 3e-11
Identities = 27/96 (28%), Positives = 45/96 (46%), Gaps = 3/96 (3%)

Query: 31 DDVVFEPDTKFAAFAKDENGKVVGGIRAVAFWN-YCILELLWLSDETRGQGVGSKLMDAA 89
DV + + AAF +G I+ + WN Y ++E + ++ + R +GVG+ L+ A
Sbjct: 55 MDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAVAKDYRKKGVGTALLHKA 114

Query: 90 ENFAKEKGFGYMRTETLSFQ--AKPFYEKRGYKVFG 123
+AKE F + ET A FY K + +
Sbjct: 115 IEWAKENHFCGLMLETQDINISACHFYAKHHFIIGA 150


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2276SECA330.005 SecA protein signature.
		>SECA#SecA protein signature.

Length = 901

Score = 32.5 bits (74), Expect = 0.005
Identities = 15/58 (25%), Positives = 21/58 (36%), Gaps = 15/58 (25%)

Query: 30 RGYEAVQRDPAIE-------LFIEMMTAPALEVIRQ------HVEENYEHFEDDELPD 74
RGY Q+DP E +F M+ + EVI + E E E +
Sbjct: 792 RGYA--QKDPKQEYKRESFSMFAAMLESLKYEVISTLSKVQVRMPEEVEELEQQRRME 847


30Spea_2301Spea_2326Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_2301018-4.473600hypothetical protein
Spea_2302018-3.974675hypothetical protein
Spea_2303019-3.978724hypothetical protein
Spea_2304-122-6.089577hypothetical protein
Spea_2305-124-5.985912hypothetical protein
Spea_2306-125-6.807611hypothetical protein
Spea_2307030-7.994181SMC domain-containing protein
Spea_2308035-8.871407hypothetical protein
Spea_2309034-8.853861sigma-70 region 4 domain-containing protein
Spea_2310-119-5.679977hypothetical protein
Spea_2311-118-5.746083hypothetical protein
Spea_2312-116-5.630972hypothetical protein
Spea_2313-114-5.130539type III restriction protein res subunit
Spea_2314-212-3.682829HNH nuclease
Spea_2315-29-1.739535hypothetical protein
Spea_2316-1120.073477putative orphan protein
Spea_2317-1141.622623hypothetical protein
Spea_23180173.684063hypothetical protein
Spea_2319-1133.215517putative AcnD-accessory protein PrpF
Spea_2320-1132.231304aconitate hydratase
Spea_2321-1140.2483392-methylcitrate synthase/citrate synthase II
Spea_2322016-0.3383902-methylisocitrate lyase
Spea_2323014-1.128788GntR family transcriptional regulator
Spea_2324114-1.574734N-acetyltransferase GCN5
Spea_2325016-3.318977diguanylate cyclase
Spea_2326-115-3.558829sulfatase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2307CHANLCOLICIN320.009 Channel forming colicin signature.
		>CHANLCOLICIN#Channel forming colicin signature.

Length = 522

Score = 32.0 bits (72), Expect = 0.009
Identities = 57/287 (19%), Positives = 108/287 (37%), Gaps = 51/287 (17%)

Query: 214 AQIDKLESDRTAAEHAAVELTNKASLCRAKIELIAKDI---------------------- 251
AQ+ K ++++ A AA E KA R + KDI
Sbjct: 60 AQLKKTQAEQAARAKAAAEAQAKAKANRDALTQRLKDIVNEALRHNASRTPSATELAHAN 119

Query: 252 ------EKTELDLSSRGGAWAQSREQEKAKQFELDAERKELEKTLRAEIEGDLPFALAPN 305
E L L+ + E + E + RKE+E+ +AE E L A A
Sbjct: 120 NAAMQAEDERLRLAKAEEKARKEAEAAEKAFQEAEQRRKEIERE-KAETERQLKLAEAEE 178

Query: 306 AMQALLTQLE-----AEKKAKQADSFNSELKGFLTELEQKLSFSLSNSFVAIETIKECLN 360
A L++ A+KK A S ++ G + L +LS S+ ++T+ N
Sbjct: 179 KRLAALSEEAKAVEIAQKKLSAAQSEVVKMDGEIKTLNSRLSSSIHARDAEMKTLAGKRN 238

Query: 361 D----RESQQVKTDIQLDLADREYDQIKAQINNQAPSSYKR----FDEARKRLAIVEEQL 412
+ + ++ L+ R D ++ + +A +E +K++ E ++
Sbjct: 239 ELAQASAKYKELDELVKKLSPRANDPLQNRPFFEATRRRVGAGKIREEKQKQVTASETRI 298

Query: 413 DSISINIARAPEQEQLETQLEALKELNSRRTAAIVEHRDTTEAAKRK 459
+ I+ +I + +A+ ++++ R A I + E K+
Sbjct: 299 NRINADITQIQ---------KAISQVSNNRNAGIARVHEAEENLKKA 336


31Spea_2370Spea_2375Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_2370-113-3.875605hypothetical protein
Spea_2371-113-3.899044gonadoliberin III-like protein
Spea_2372-215-4.262194alpha-L-glutamate ligase-like protein
Spea_2373-215-3.913504peptidase M3A and M3B, thimet/oligopeptidase F
Spea_2374-118-3.132980hypothetical protein
Spea_2375-221-3.431822histidine kinase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2373TYPE4SSCAGA300.027 Type IV secretion system CagA exotoxin signature.
		>TYPE4SSCAGA#Type IV secretion system CagA exotoxin signature.

Length = 1147

Score = 30.4 bits (68), Expect = 0.027
Identities = 16/64 (25%), Positives = 32/64 (50%)

Query: 382 IESMAKIITQFASGQPFYLNNTIGETQDTAQIDTLWLQQYLQNQLMPKLAADSREAIVLK 441
+ES K +F + + + D ++I+T ++ +++N + P + D +A LK
Sbjct: 102 VESSTKSFQKFGDQRYRIFTSWVSHQNDPSKINTRSIRNFMENIIQPPILDDKEKAEFLK 161

Query: 442 YAKQ 445
AKQ
Sbjct: 162 SAKQ 165


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2375HTHFIS619e-12 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 61.0 bits (148), Expect = 9e-12
Identities = 25/123 (20%), Positives = 51/123 (41%), Gaps = 7/123 (5%)

Query: 682 SKKIVLVVEDNKVNQQVVSINLKKLNLPYLIANDGREALENYKRHIGGVSVILMDCMMPI 741
+ +LV +D+ + V++ L + I ++ G +++ D +MP
Sbjct: 2 TGATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAA--GDGDLVVTDVVMPD 59

Query: 742 MDGFEATRAIRIFEKEEGEPRVTIIALTASILDDDIQKCFESGMDDYLPKPFKRDVLVRK 801
+ F+ I+ + P + ++ ++A K E G DYLPKPF L+
Sbjct: 60 ENAFDLLPRIK-----KARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGI 114

Query: 802 LAK 804
+ +
Sbjct: 115 IGR 117


32Spea_2408Spea_2413Y        NNGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_2408217-2.941272intracellular proteinase inhibitor
Spea_2409214-3.329482AsmA family protein
Spea_2410217-2.948381ribonuclease activity A regulator
Spea_2411216-2.255199hypothetical protein
Spea_2412215-1.428163putative sulfite oxidase subunit YedZ
Spea_2413216-0.139526putative sulfite oxidase subunit YedY
33Spea_2470Spea_2482Y        NNGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_2470012-3.237099phenylalanyl-tRNA synthetase subunit alpha
Spea_2471016-3.533850methyl-accepting chemotaxis sensory transducer
Spea_2472016-3.960745putative PAS/PAC sensor protein
Spea_2473-216-2.497359hypothetical protein
Spea_2474-117-3.182011hypothetical protein
Spea_2475015-1.903040hypothetical protein
Spea_2476-115-2.303860hypothetical protein
Spea_2477013-2.007704pyridoxamine 5'-phosphate oxidase
Spea_2478-113-2.069448agmatinase
Spea_2479012-2.343218adenosylmethionine decarboxylase
Spea_2480114-1.823040arginine decarboxylase
Spea_2481318-2.821888hypothetical protein
Spea_2482214-2.287026hypothetical protein
34Spea_2588Spea_2601Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_2588014-3.933803chorismate synthase
Spea_2589015-4.798980N5-glutamine S-adenosyl-L-methionine-dependent
Spea_2590016-5.199172hypothetical protein
Spea_2591117-5.608112phosphohistidine phosphatase SixA
Spea_2592119-5.958043peptidase M16 domain-containing protein
Spea_2593119-5.110000PAS/PAC sensor-containing diguanylate
Spea_25940180.788101hypothetical protein
Spea_2595-1171.576780hypothetical protein
Spea_2596-1132.153762hypothetical protein
Spea_2597-1122.227302hypothetical protein
Spea_2598-2112.186654multifunctional fatty acid oxidation complex
Spea_25990132.2190553-ketoacyl-CoA thiolase
Spea_26001141.872157ATPase
Spea_26012141.373634hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2600HTHFIS320.003 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 32.1 bits (73), Expect = 0.003
Identities = 34/131 (25%), Positives = 50/131 (38%), Gaps = 17/131 (12%)

Query: 34 DGHLLVEGPPGLAKT---RAVKALCDGVEGDFHRIQ---FTPDLLPADLTG------TDI 81
D L++ G G K RA+ G F I DL+ ++L G T
Sbjct: 160 DLTLMITGESGTGKELVARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGA 219

Query: 82 YRAQTATFEFEAGPIFHNLILADEINRAPAKVQSALLEAMAEGQVT-VGKHSYQLPELFL 140
T FE G + DEI P Q+ LL + +G+ T VG + ++ +
Sbjct: 220 QTRSTGRFEQAEG----GTLFLDEIGDMPMDAQTRLLRVLQQGEYTTVGGRTPIRSDVRI 275

Query: 141 VMATQNPLENE 151
V AT L+
Sbjct: 276 VAATNKDLKQS 286


35Spea_2675Spea_2682Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_2675221-0.855417ABC transporter-like protein
Spea_2676322-0.538447trans-2-enoyl-CoA reductase
Spea_2677527-0.721513PpiC-type peptidyl-prolyl cis-trans isomerase
Spea_2678424-0.393756histone family protein DNA-binding protein
Spea_2679321-0.325969ATP-dependent protease La
Spea_2680326-0.636144ATP-dependent protease ATP-binding subunit ClpX
Spea_2681225-0.414300ATP-dependent Clp protease proteolytic subunit
Spea_2682223-0.747930trigger factor
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2675PF05272300.015 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 29.7 bits (66), Expect = 0.015
Identities = 12/50 (24%), Positives = 19/50 (38%), Gaps = 1/50 (2%)

Query: 43 LAIVGEAGSGKSTIARILVGAEIRSGGEIFFEGEPLDKHDLKQRCRLIRM 92
+ + G G GKST+ LVG + S G D ++ +
Sbjct: 599 VVLEGTGGIGKSTLINTLVGLDFFSDTHFDI-GTGKDSYEQIAGIVAYEL 647


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2678DNABINDINGHU1172e-38 Prokaryotic integration host factor signature.
		>DNABINDINGHU#Prokaryotic integration host factor signature.

Length = 91

Score = 117 bits (295), Expect = 2e-38
Identities = 50/88 (56%), Positives = 67/88 (76%)

Query: 2 NKSELIEKIASGADISKAAAGRALDSFIGAVTEGLKEGDKIALVGFGTFEVRQRAERTGR 61
NK +LI K+A +++K + A+D+ AV+ L +G+K+ L+GFG FEVR+RA R GR
Sbjct: 3 NKQDLIAKVAEATELTKKDSAAAVDAVFSAVSSYLAKGEKVQLIGFGNFEVRERAARKGR 62

Query: 62 NPQTGKEIKIAAANIPAFKAGKALKDAV 89
NPQTG+EIKI A+ +PAFKAGKALKDAV
Sbjct: 63 NPQTGEEIKIKASKVPAFKAGKALKDAV 90


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2679HTHFIS350.001 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 34.8 bits (80), Expect = 0.001
Identities = 28/152 (18%), Positives = 60/152 (39%), Gaps = 26/152 (17%)

Query: 304 HKRSKIKRDLAKAQDVLD--TDHFGLEKVKERILEYLAVQSRVKQLKGPILCLVGPPGVG 361
+ + + +QD + ++++ + +R+ Q ++ + G G G
Sbjct: 121 EPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVL-------ARLMQTDLTLM-ITGESGTG 172

Query: 362 KTSLGQSIAKATGRK---YVRVALGGVRD---EAEIRGHRRTYIGSMPGKVIQKMSKVGV 415
K + +++ R+ +V + + + E+E+ GH + G+ G + +
Sbjct: 173 KELVARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEK---GAFTGAQTRSTGRFEQ 229

Query: 416 KN--PLFLLDEIDKMSSDMRGDPASALLEVLD 445
LFL DEI M D + + LL VL
Sbjct: 230 AEGGTLFL-DEIGDMPMDAQ----TRLLRVLQ 256


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2680HTHFIS310.013 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 30.6 bits (69), Expect = 0.013
Identities = 14/74 (18%), Positives = 30/74 (40%), Gaps = 13/74 (17%)

Query: 60 QDQDKLPTPHELRAHLDDYVIGQDKAKKVLAVAVYNHYKRLRNASPKDGVELGKSNILLI 119
+ + P+ E + ++G+ A + + Y+ L D +++
Sbjct: 120 AEPKRRPSKLEDDSQDGMPLVGRSAAMQEI-------YRVLARLMQTD------LTLMIT 166

Query: 120 GPTGSGKTLLAETL 133
G +G+GK L+A L
Sbjct: 167 GESGTGKELVARAL 180


36Spea_2693Spea_2698Y        NNGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_26932160.504775outer membrane protein
Spea_26944190.921523decaheme cytochrome c MtrF
Spea_26954230.373913decaheme cytochrome c
Spea_2696524-0.274018hypothetical protein
Spea_2697425-0.075107decaheme cytochrome c
Spea_26982200.310311decaheme cytochrome c
37Spea_2715Spea_2721Y        NNGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_2715-313-3.686075pyridoxal-dependent decarboxylase
Spea_2716-216-5.696501hypothetical protein
Spea_2717018-6.806231AraC family transcriptional regulator
Spea_2718-116-6.111600hypothetical protein
Spea_2719-116-5.158173diguanylate cyclase
Spea_2720-116-4.689170basic membrane lipoprotein
Spea_2721-117-4.415098hypothetical protein
38Spea_2775Spea_2780Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_27752142.614529hypothetical protein
Spea_27762143.171227short-chain dehydrogenase/reductase SDR
Spea_27772133.3973313-ketoacyl-ACP reductase
Spea_27783154.3133173-hydroxyisobutyrate dehydrogenase
Spea_27791143.714581enoyl-CoA hydratase/isomerase
Spea_27801153.198183enoyl-CoA hydratase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2777DHBDHDRGNASE1074e-30 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase sig...
		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

signature.
Length = 261

Score = 107 bits (267), Expect = 4e-30
Identities = 74/263 (28%), Positives = 128/263 (48%), Gaps = 22/263 (8%)

Query: 3 LKDKVVVITGGAGGLGYAMAENLAAAGAKLALIDVDQEKLEKACANLGASTEVQ-GYAVD 61
++ K+ ITG A G+G A+A LA+ GA +A +D + EKLEK ++L A + D
Sbjct: 6 IEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPAD 65

Query: 62 ITDEEDVFATFQFIKEDFGQVNVLINNAGILRDGLLLKAKEGQVFERMSFDQFQSVINVN 121
+ D + I+ + G +++L+N AG+LR GL+ +S +++++ +VN
Sbjct: 66 VRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLI---------HSLSDEEWEATFSVN 116

Query: 122 LTGSFLCGREAAAAMIETGQEGVIINISSLAKAGNVGQTNYAASKAGVAAMSVGWAKELA 181
TG F R + M++ ++ S+ A YA+SKA + ELA
Sbjct: 117 STGVFNASRSVSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELA 176

Query: 182 RYNIRSAAVAPGVIETEMTAAMKPE----------ALERLEKMVPVGRLGQAEEIASTVR 231
YNIR V+PG ET+M ++ + +LE + +P+ +L + +IA V
Sbjct: 177 EYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVL 236

Query: 232 FIIEND--YVNGRVFEIDGGIRL 252
F++ ++ +DGG L
Sbjct: 237 FLVSGQAGHITMHNLCVDGGATL 259


39Spea_2793Spea_2798Y        NNGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_27930133.2184491,4-dihydroxy-2-naphthoate
Spea_27940153.2308466-phosphogluconate dehydrogenase
Spea_2795-1153.580504AMP-dependent synthetase and ligase
Spea_27960173.460555MerR family transcriptional regulator
Spea_2797-1173.672374acyl-CoA dehydrogenase domain-containing
Spea_27980173.432316propionyl-CoA carboxylase
40Spea_2812Spea_2846Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_28122131.106756nitrite reductase
Spea_28134240.946518hypothetical protein
Spea_28144240.879776endoribonuclease L-PSP
Spea_28154241.063990hypothetical protein
Spea_28163240.591400cytoplasmic chaperone TorD family protein
Spea_28172200.429871dimethylsulfoxide reductase subunit B
Spea_28182190.069653anaerobic dimethyl sulfoxide reductase subunit
Spea_2819011-0.601074outer membrane protein
Spea_2820212-0.222751cytochrome C family protein
Spea_28212170.402146isoprenylcysteine carboxyl methyltransferase
Spea_28220150.736108hypothetical protein
Spea_28231171.017840hypothetical protein
Spea_28240170.830234hypothetical protein
Spea_28250171.157218MoxR-like protein ATPase-like protein
Spea_28261180.408135hypothetical protein
Spea_2827117-0.050640hypothetical protein
Spea_2828017-1.298527hypothetical protein
Spea_2829017-3.375308hypothetical protein
Spea_2830-115-3.917693hypothetical protein
Spea_2831019-3.982365hypothetical protein
Spea_2832122-5.286340hypothetical protein
Spea_2833226-6.305882hypothetical protein
Spea_2834124-5.272184hypothetical protein
Spea_2835021-3.406206hypothetical protein
Spea_2836121-2.351384Sel1 domain-containing protein
Spea_2837-123-3.522826hypothetical protein
Spea_2838-122-3.264893hypothetical protein
Spea_2839-122-3.519443hypothetical protein
Spea_2841-124-4.745491putative hydrolase
Spea_2842025-5.317475hypothetical protein
Spea_2843-223-5.499902TonB-dependent receptor
Spea_2844-219-4.955638LysR family transcriptional regulator
Spea_2845-115-3.956772hypothetical protein
Spea_2846-113-3.527464hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2841PF06057300.010 Type IV secretory pathway VirJ component
		>PF06057#Type IV secretory pathway VirJ component

Length = 243

Score = 29.8 bits (67), Expect = 0.010
Identities = 17/64 (26%), Positives = 29/64 (45%), Gaps = 5/64 (7%)

Query: 110 LADDVAQIVHHDIAETGNAETVLLIGHAFGNRVMRATASKYP----DIAKGVVLIAAGGQ 165
+ D I+ AE G + V+LIG++FG V+ ++ P G VL++
Sbjct: 99 VTQDTLAIIDKYQAEFG-TQKVILIGYSFGAEVIPFVLNEMPARYRKNVLGAVLLSPSQS 157

Query: 166 REVE 169
+ E
Sbjct: 158 SDFE 161


41Spea_2877Spea_2894Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_2877217-1.313174surface antigen (D15)
Spea_2878016-0.872450putative membrane-associated zinc
Spea_2879020-1.4699281-deoxy-D-xylulose 5-phosphate reductoisomerase
Spea_2880231-1.395406phosphatidate cytidylyltransferase
Spea_2881333-1.544128undecaprenyl diphosphate synthase
Spea_2882223-1.229439ribosome recycling factor
Spea_2883125-0.875043uridylate kinase
Spea_2884224-1.017869elongation factor Ts
Spea_2885116-0.61930230S ribosomal protein S2
Spea_2886011-0.428131methionine aminopeptidase
Spea_2887-112-0.290563PII uridylyl-transferase
Spea_2888-115-0.5659862,3,4,5-tetrahydropyridine-2,6-carboxylate
Spea_2889-119-1.193345hypothetical protein
Spea_2890022-1.440821flavodoxin
Spea_2891020-1.640349pseudouridine synthase
Spea_2892421-2.500060hypothetical protein
Spea_2893521-2.738310hypothetical protein
Spea_2894627-3.121293hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2877ENTEROVIROMP330.002 Enterobacterial virulence outer membrane protein si...
		>ENTEROVIROMP#Enterobacterial virulence outer membrane protein

signature.
Length = 171

Score = 33.3 bits (76), Expect = 0.002
Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 17/121 (14%)

Query: 430 SFNAGVGYGTESGLSLQFGVQQSNFLGTGNQA-GVNLNTNKYSKNVNINYTDPYFTKDGV 488
+F AG S ++ G QS+ G N+ G NL KY Y + +
Sbjct: 15 AFTAGTSVAATSTVTG--GYAQSDAQGQMNKMGGFNL---KY------RYEE---DNSPL 60

Query: 489 SLGGSIYWSEFDADEANLEAYKNSSYGVSLNSGFPINEYNRING--GIGYRHNEISEISA 546
+ GS ++E ++ + KN YG++ + IN++ I G G+GY + +E
Sbjct: 61 GVIGSFTYTEKSRTASSGDYNKNQYYGITAGPAYRINDWASIYGVVGVGYGKFQTTEYPT 120

Query: 547 Y 547
Y
Sbjct: 121 Y 121


42Spea_2903Spea_2921Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_29032141.970992LysR family transcriptional regulator
Spea_29041152.452955beta-lactamase domain-containing protein
Spea_29051172.8143724'-phosphopantetheinyl transferase
Spea_29060172.701066transcriptional regulator
Spea_29071182.645980polyketide-type polyunsaturated fatty acid
Spea_2908-1132.530590PfaB family protein
Spea_2909-2132.469154beta-hydroxyacyl-(acyl-carrier-protein)
Spea_29100121.204552PfaD family protein
Spea_2912016-3.002027diguanylate cyclase
Spea_2913020-3.694489hypothetical protein
Spea_2914021-3.909861penicillin amidase
Spea_2915235-9.607716hypothetical protein
Spea_2916339-10.978040hypothetical protein
Spea_2917035-9.430377putative deoxyguanosinetriphosphate
Spea_2918030-8.595653hypothetical protein
Spea_2919132-8.691780integrase, catalytic region
Spea_2920231-8.395317hypothetical protein
Spea_2921120-5.659952radical SAM domain-containing protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2907PF03544330.012 Gram-negative bacterial tonB protein
		>PF03544#Gram-negative bacterial tonB protein

Length = 243

Score = 33.0 bits (75), Expect = 0.012
Identities = 19/93 (20%), Positives = 25/93 (26%), Gaps = 6/93 (6%)

Query: 1201 PATPVQPAPVQTTAVQTAPTQAPQVKTAPVATTPQVQAPQVVRQAAPAQAAVV------P 1254
P P+ T V A + PQ P + + P +A VV
Sbjct: 41 IELPAPAQPISVTMVAPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPK 100

Query: 1255 TNTSPVAVISAETALSATLSSEKVQATMLEVVA 1287
P V E E A+ E A
Sbjct: 101 PKPKPKPVKKVEQPKRDVKPVESRPASPFENTA 133



Score = 32.6 bits (74), Expect = 0.019
Identities = 25/133 (18%), Positives = 42/133 (31%), Gaps = 11/133 (8%)

Query: 1169 SPATYAPVIENKVIQTEVVQREVV---AQPAIIATPATPVQPAPVQTTAVQTAPTQAPQV 1225
PA P+ V ++ + V +P + P P P + AP +
Sbjct: 43 LPAPAQPISVTMVAPADLEPPQAVQPPPEPVVEPEPEPEPIPEP-----PKEAPVVIEKP 97

Query: 1226 KTAPVATTPQVQA-PQVVRQAAPAQ--AAVVPTNTSPVAVISAETALSATLSSEKVQATM 1282
K P V+ Q R P + A NT+P S+ + + V +
Sbjct: 98 KPKPKPKPKPVKKVEQPKRDVKPVESRPASPFENTAPARPTSSTATAATSKPVTSVASGP 157

Query: 1283 LEVVAEKTGYPTE 1295
+ + YP
Sbjct: 158 RALSRNQPQYPAR 170


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2913BCTERIALGSPG482e-09 Bacterial general secretion pathway protein G signa...
		>BCTERIALGSPG#Bacterial general secretion pathway protein G

signature.
Length = 145

Score = 47.6 bits (113), Expect = 2e-09
Identities = 17/52 (32%), Positives = 32/52 (61%)

Query: 6 KGFTLIELVVVIIILGILAIVAIPKFINLQNDARMSAMAGQFGAFKSAVGLY 57
+GFTL+E++VVI+I+G+LA + +P + + A A ++A+ +Y
Sbjct: 8 RGFTLLEIMVVIVIIGVLASLVVPNLMGNKEKADKQKAVSDIVALENALDMY 59


43Spea_3052Spea_3060Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_3052225-1.001888hypothetical protein
Spea_3053224-0.889606peptide chain release factor 3
Spea_3054323-1.047854lipoprotein NlpI
Spea_3055434-0.561480polynucleotide phosphorylase/polyadenylase
Spea_3056528-0.412937diguanylate cyclase/phosphodiesterase
Spea_3057636-0.38742830S ribosomal protein S15
Spea_3058635-0.417571tRNA pseudouridine synthase B
Spea_3059536-0.421721ribosome-binding factor A
Spea_30603320.145173translation initiation factor IF-2
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3052BINARYTOXINB260.026 Binary toxin B family signature.
		>BINARYTOXINB#Binary toxin B family signature.

Length = 764

Score = 25.8 bits (56), Expect = 0.026
Identities = 11/54 (20%), Positives = 15/54 (27%), Gaps = 9/54 (16%)

Query: 8 WHQYIQWCDSM---------GLTPENRRSCAPRLTDPELKPAPKFKLAPELESA 52
W + + L RR A +DP P L L+ A
Sbjct: 506 WSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIA 559


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3053TCRTETOQM2032e-60 Tetracycline resistance protein TetO/TetQ/TetM family ...
		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

signature.
Length = 639

Score = 203 bits (519), Expect = 2e-60
Identities = 107/460 (23%), Positives = 209/460 (45%), Gaps = 45/460 (9%)

Query: 10 KRRTFAIISHPDAGKTTITEKVLLFGNALQKAGTV-KGKKSGQHAKSDWMEMEKDRGISI 68
K +++H DAGKTT+TE +L A+ + G+V KG ++D +E+ RGI+I
Sbjct: 2 KIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGT-----TRTDNTLLERQRGITI 56

Query: 69 TTSVMQFPYSDALVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDSAKGVEQRTIKLMEVT 128
T + F + + VN++DTPGH DF + YR+L+ +D +++I + GV+ +T L
Sbjct: 57 QTGITSFQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHAL 116

Query: 129 RLRDTPIVTFMNKLDRDIRDPIELMDEVEEVLNIKCAPITWPIGAGKEFKGVYHLLRDEV 188
R P + F+NK+D++ D + +++E L+ + + +V
Sbjct: 117 RKMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAEIVI------------------KQKV 158

Query: 189 ILYQGGMGHTIQDSRVIKGLDNPELDEAIGSYAAEIRDEMELVVGASHEFDHQQFLKGEL 248
LY +S + D+ + Y + E + + + +F L
Sbjct: 159 ELYPNMCVTNFTESEQWDTVIEGN-DDLLEKYMSGKSLEALEL----EQEESIRFHNCSL 213

Query: 249 TPVYFGTALGNFGVDHILDGIVEWAPVPQPRETEIREVQPEEEKFSGFVFKIQANMDPKH 308
PVY G+A N G+D++++ I R + + G VFKI+ K
Sbjct: 214 FPVYHGSAKNNIGIDNLIEVITNKFYSSTHR---------GQSELCGKVFKIE--YSEK- 261

Query: 309 RDRVAFMRICSGRYEQGMKMHHVRLGKDVNVSDALTFMAGDRNRAEAAYPGDIIGLHNHG 368
R R+A++R+ SG + K + +++ T + G+ + + AY G+I+ L N
Sbjct: 262 RQRLAYIRLYSGVLHLRDSVRISEKEK-IKITEMYTSINGELCKIDKAYSGEIVILQNEF 320

Query: 369 TIRIGDTFTQGEKLRFTGVPNFAPEMFR-RIRLKDPLKQKQLLKGLVQLSEEG-AVQVFR 426
+++ + L + + + P +++ LL L+++S+ ++ +
Sbjct: 321 -LKLNSVLGDTKLLPQRERIENPLPLLQTTVEPSKPQQREMLLDALLEISDSDPLLRYYV 379

Query: 427 PLDSNDLIVGAVGVLQFEVVVGRLKTEYKVEAIYEAISVA 466
++++I+ +G +Q EV L+ +Y VE + +V
Sbjct: 380 DSATHEIILSFLGKVQMEVTCALLQEKYHVEIEIKEPTVI 419


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3055RTXTOXIND330.004 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 32.9 bits (75), Expect = 0.004
Identities = 35/192 (18%), Positives = 63/192 (32%), Gaps = 27/192 (14%)

Query: 497 VAGTRDGITALQMDIKIEGITKEIMQIALKQAYGARVHILDVMDRAISGHRGDISEHAPR 556
I + ++E + L + A+ +L+ + ++ + +
Sbjct: 216 RLTVLARINRYENLSRVEKSRLDDFSSLLHKQAIAKHAVLE-QENKYVEAVNELRVYKSQ 274

Query: 557 ITTIKINPEKIRDVIGKGGATIRALTEETGTTIELDD--DGTVKIASSNGEATK-EAIRR 613
+ E+I I + +T+ I LD T I E K E ++
Sbjct: 275 L-------EQIESEILSAKEEYQLVTQLFKNEI-LDKLRQTTDNIGLLTLELAKNEERQQ 326

Query: 614 IEEITAEVEVGTVYNGKVVRIVDFGAFVT-------ILPGKDGLVHISQIAEERVANVSD 666
I A V V KV G VT I+P D L + + + +
Sbjct: 327 ASVIRAPVS-VKVQQLKVHTE---GGVVTTAETLMVIVPEDDTLEVTALVQNKDI----G 378

Query: 667 YLEVGQEVKVKV 678
++ VGQ +KV
Sbjct: 379 FINVGQNAIIKV 390


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3060TCRTETOQM742e-15 Tetracycline resistance protein TetO/TetQ/TetM family ...
		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

signature.
Length = 639

Score = 73.7 bits (181), Expect = 2e-15
Identities = 69/279 (24%), Positives = 102/279 (36%), Gaps = 80/279 (28%)

Query: 403 IMGHVDHGKTSLLDYI-----RRAKVASGEAG-------------GITQHIGAYHVETEN 444
++ HVD GKT+L + + ++ S + G GIT G + EN
Sbjct: 8 VLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGITSFQWEN 67

Query: 445 GMITFLDTPGHAAFTAMRARGAKATDIVILVVAADDGVMPQTIEAIQHAKAGGVPLIVAV 504
+ +DTPGH F A R D IL+++A DGV QT + G+P I +
Sbjct: 68 TKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALRKMGIPTIFFI 127

Query: 505 NKIDKPEADPDRV----KSELSQHGVM-----------------SEDWG----GNNMFV- 538
NKID+ D V K +LS V+ SE W GN+ +
Sbjct: 128 NKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVELYPNMCVTNFTESEQWDTVIEGNDDLLE 187

Query: 539 ------------------------------HVSAKDGTGIDELLEGILLEAEVLELQAVR 568
H SAK+ GID L+E I + +
Sbjct: 188 KYMSGKSLEALELEQEESIRFHNCSLFPVYHGSAKNNIGIDNLIEVITNKF----YSSTH 243

Query: 569 EGMA--AGVVVESKLDKGRGPVATVLVQEGTLKQGDIVL 605
G + G V + + + R +A + + G L D V
Sbjct: 244 RGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLHLRDSVR 282


44Spea_3215Spea_3227Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_32152110.160069dihydroorotase
Spea_3216212-1.144573hypothetical protein
Spea_3217211-1.344783hypothetical protein
Spea_3218112-2.229630PpiC-type peptidyl-prolyl cis-trans isomerase
Spea_3219013-2.562314glucose sorbosone dehydrogenase
Spea_3220015-3.801108hypothetical protein
Spea_3221-118-4.678062glutathione synthetase
Spea_3222-120-2.973171hypothetical protein
Spea_3223-119-2.446586diguanylate cyclase
Spea_3224016-1.647825outer membrane adhesin-like protein
Spea_3225117-1.006723hypothetical protein
Spea_3226118-0.092892LVIVD repeat-containing protein
Spea_32272201.013896ferredoxin-dependent glutamate synthase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3221HELNAPAPROT280.032 Helicobacter neutrophil-activating protein A family ...
		>HELNAPAPROT#Helicobacter neutrophil-activating protein A family

signature.
Length = 153

Score = 27.9 bits (62), Expect = 0.032
Identities = 12/62 (19%), Positives = 21/62 (33%)

Query: 275 IDVINEKLIEVNVQSPGGIMRINKLNNVKLQKKVIDFVESVVNAKEALTQRRSEFRKAID 334
+D I E+L+ + Q + + ++ E V Q SE + I
Sbjct: 61 VDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQALVNDYKQISSESKFVIG 120

Query: 335 DA 336
A
Sbjct: 121 LA 122


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3224FLAGELLIN310.009 Flagellin signature.
		>FLAGELLIN#Flagellin signature.

Length = 507

Score = 30.8 bits (69), Expect = 0.009
Identities = 42/194 (21%), Positives = 68/194 (35%), Gaps = 14/194 (7%)

Query: 168 TNEDVELRSSLIVAEVDS--DELQFVLVTDTLNGVVTLSESGEYSYQATANFNGTDSFTF 225
TN D +L+S I E+ +E+ V NGV LS+ + Q AN T +
Sbjct: 102 TNSDSDLKS--IQDEIQQRLEEIDRVSNQTQFNGVKVLSQDNQMKIQVGANDGETITIDL 159

Query: 226 SVTDG---------VNAAVEASVTINILAV-NDAPVASHQSLNIGYNREVASRLSAFDVD 275
D VN EA+V + N ++ Y +V S D
Sbjct: 160 QKIDVKSLGLDGFNVNGPKEATVGDLKSSFKNVTGYDTYAVGANKYRVDVNSGAVVTDTT 219

Query: 276 EDELMFEVVTNVSHGELALNDDGSFIYNPKTDFSGNDSFTYRVTDTAGSTSEAVVSITVS 335
+ +V N ++G+L +D + + + + T AG+ T
Sbjct: 220 APTVPDKVYVNAANGQLTTDDAENNTAVDLFKTTKSTAGTAEAKAIAGAIKGGKEGDTFD 279

Query: 336 AKPKESTSDSSGGS 349
K T D+ G+
Sbjct: 280 YKGVTFTIDTKTGN 293


45Spea_3280Spea_3311Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_32803263.423343multiple resistance and pH regulation protein F
Spea_32813253.189510monovalent cation/proton antiporter subunit
Spea_32824253.498105putative monovalent cation/H+ antiporter subunit
Spea_32834241.733798NADH-ubiquinone oxidoreductase chain 4L
Spea_32843211.306995putative monovalent cation/H+ antiporter subunit
Spea_3285319-0.310994NADH dehydrogenase (quinone)
Spea_3286217-2.506436hypothetical protein
Spea_3287117-2.468450putative monovalent cation/H+ antiporter subunit
Spea_3288119-5.583275hypothetical protein
Spea_3289019-4.561078hypothetical protein
Spea_3290223-4.466692hypothetical protein
Spea_3291424-5.945344hypothetical protein
Spea_3292427-6.983479hypothetical protein
Spea_3293632-9.578847hypothetical protein
Spea_3294534-9.335945hypothetical protein
Spea_3295335-9.255356hypothetical protein
Spea_3296020-4.135853hypothetical protein
Spea_3297020-2.869705hypothetical protein
Spea_3298022-1.149320NACHT family-like NTPase
Spea_32991243.109767hypothetical protein
Spea_33001234.133537hypothetical protein
Spea_33010244.350783glycine dehydrogenase
Spea_33020163.982169glycine cleavage system protein H
Spea_33030153.566387glycine cleavage system aminomethyltransferase
Spea_33041152.627027UbiH/UbiF/VisC/COQ6 family ubiquinone
Spea_33052171.6765342-polyprenyl-6-methoxyphenol 4-hydroxylase
Spea_33061170.399225yecA family protein
Spea_3307317-0.181475hypothetical protein
Spea_3308416-0.182360hypothetical protein
Spea_33094170.806653hypothetical protein
Spea_33103171.272308hypothetical protein
Spea_33112171.3236875-formyltetrahydrofolate cyclo-ligase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3309BACINVASINB290.016 Salmonella/Shigella invasin protein B signature.
		>BACINVASINB#Salmonella/Shigella invasin protein B signature.

Length = 593

Score = 29.3 bits (65), Expect = 0.016
Identities = 16/48 (33%), Positives = 23/48 (47%)

Query: 185 EAKKAEIAGSVGGALVGAKVGAVMGSIVPGAGTIVGAAAGATIGKHFG 232
+ K AE+AGS+ GA+V A + +V G A G + K G
Sbjct: 399 DKKTAEMAGSIVGAIVAAIAMVAVIVVVAVVGKGAAAKLGNALSKMMG 446


46Spea_3325Spea_3336Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_33252161.232044pyridoxamine 5'-phosphate oxidase-like
Spea_33262161.391879hypothetical protein
Spea_33272152.483921TonB-dependent heme/hemoglobin receptor family
Spea_33284163.339490TonB family protein
Spea_33293172.554964MotA/TolQ/ExbB proton channel
Spea_33302201.742108biopolymer transport protein ExbD/TolR
Spea_33311171.722235periplasmic-binding protein
Spea_33322201.367020transport system permease
Spea_3333-119-0.690837hemin importer ATP-binding subunit
Spea_3334121-0.026263TetR family transcriptional regulator
Spea_33352190.087216deaminase-reductase domain-containing protein
Spea_33363180.276900hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3328PF03544752e-18 Gram-negative bacterial tonB protein
		>PF03544#Gram-negative bacterial tonB protein

Length = 243

Score = 75.4 bits (185), Expect = 2e-18
Identities = 42/210 (20%), Positives = 81/210 (38%), Gaps = 19/210 (9%)

Query: 43 AVSISIAMQASQAVKTPEQVQAPVETQAKPTTQANPVAQTIAKPQPIAKTNAIAQTQAKP 102
A IS+ M A ++ P+ VQ P E +P + P+ + + +
Sbjct: 47 AQPISVTMVAPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPV----------VIEK 96

Query: 103 LSPKMAVTDKPKTLKEVAKKLDPIKPIEKTQESAAEVQTEQLSHNQPKADAKQGVSKQAV 162
PK KP K+V + +KP+E S E + A SK
Sbjct: 97 PKPKPKPKPKPV--KKVEQPKRDVKPVESRPASPFENTAPA---RPTSSTATAATSKPVT 151

Query: 163 ALSQPTFATPPSQPHYPKKARKKGFQGTATVEVMFNQLGEQLSLTLVDSSGYRLLDKAAL 222
+++ A +QP YP +A+ +G V+ G ++ ++ + + ++
Sbjct: 152 SVASGPRALSRNQPQYPARAQALRIEGQVKVKFDVTPDGRVDNVQILSAKPANMFEREVK 211

Query: 223 NAVEKWQFAAPSPQTAYAYTVRVPVKFALN 252
NA+ +W++ P + + V + F +N
Sbjct: 212 NAMRRWRYEPGKPGS----GIVVNILFKIN 237


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3333PF05272290.026 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 28.9 bits (64), Expect = 0.026
Identities = 10/25 (40%), Positives = 12/25 (48%)

Query: 37 KIKAGQVTALLGPNGAGKSTLLKSL 61
K L G G GKSTL+ +L
Sbjct: 592 GCKFDYSVVLEGTGGIGKSTLINTL 616


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3334TETREPRESSOR462e-08 Tetracycline repressor protein signature.
		>TETREPRESSOR#Tetracycline repressor protein signature.

Length = 218

Score = 45.7 bits (108), Expect = 2e-08
Identities = 26/90 (28%), Positives = 48/90 (53%), Gaps = 4/90 (4%)

Query: 18 LSQELIVVQAKALMLKEG-KIPSIRNLASALSVDAMAIYYYFKNKEALLEAITISLVS-- 74
L++E ++ A L+ + G + R LA L ++ +Y++ KNK ALL+A+ + +++
Sbjct: 4 LNRESVIDAALELLNETGIDGLTTRKLAQKLGIEQPTLYWHVKNKRALLDALAVEILARH 63

Query: 75 -DIYQPKTGGCWQEALTELSLSYLNLLKQY 103
D P G WQ L ++S+ L +Y
Sbjct: 64 HDYSLPAAGESWQSFLRNNAMSFRRALLRY 93


47Spea_3376Spea_3388Y        NNGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_3376-1224.336822cob(I)yrinic acid a,c-diamide
Spea_33771214.107365cobyric acid synthase
Spea_33782224.293770cobalbumin biosynthesis protein
Spea_33790183.954208cobalamin 5'-phosphate synthase
Spea_33800132.142831nicotinate-nucleotide--dimethylbenzimidazole
Spea_3381-1111.632055transport system permease
Spea_3382-190.807867ABC transporter-like protein
Spea_3383-1110.005271phosphoglycerate mutase
Spea_3384011-0.635129B12-dependent methionine synthase
Spea_3385-215-3.297497TonB-dependent receptor
Spea_3386-218-3.846807hypothetical protein
Spea_3387-115-3.688738glutathione-dependent formaldehyde-activating
Spea_3388-115-3.193424FAD-dependent pyridine nucleotide-disulfide
48Spea_3444Spea_3482Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_34440193.563562anaerobic nitric oxide reductase transcriptional
Spea_34450223.589799peptidase M16 domain-containing protein
Spea_3446-1233.389936peptidase M16 domain-containing protein
Spea_3447-1233.936993StbA family protein
Spea_34480182.866609hypothetical protein
Spea_3449-2130.640945D-serine dehydratase
Spea_3450-111-1.876600permease DsdX
Spea_3451118-3.903448DNA-binding transcriptional regulator DsdC
Spea_3452128-6.093671ATPase-like protein
Spea_3453328-7.706185hypothetical protein
Spea_3454229-7.699195phage exclusion protein Lit
Spea_3455330-7.105998hypothetical protein
Spea_3456228-6.872665hypothetical protein
Spea_3457326-7.056236XRE family transcriptional regulator
Spea_3458119-6.249354hypothetical protein
Spea_3459219-6.222277type III restriction protein res subunit
Spea_3460219-5.782189hypothetical protein
Spea_3461017-4.511336hypothetical protein
Spea_3462018-4.381069hypothetical protein
Spea_3463-116-4.149537integrase family protein
Spea_3464-115-3.792205hypothetical protein
Spea_3465-216-2.557182integrase family protein
Spea_3466-117-1.562612AFG1 family ATPase
Spea_3467119-2.385590transposase IS116/IS110/IS902 family protein
Spea_3468219-1.252891hypothetical protein
Spea_3469220-2.034209hypothetical protein
Spea_3470220-1.092113hypothetical protein
Spea_3471121-0.162953hypothetical protein
Spea_34720212.555705hypothetical protein
Spea_34731202.918123hypothetical protein
Spea_34743202.971351hypothetical protein
Spea_34751203.497586hypothetical protein
Spea_34761203.099287hypothetical protein
Spea_34770173.363279bifunctional glutamine-synthetase
Spea_3478-1162.421437hypothetical protein
Spea_3479-2171.663275hypothetical protein
Spea_3480-1151.410124spermidine synthase
Spea_3481211-0.463510hypothetical protein
Spea_3482311-0.545981phage shock protein A
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3444HTHFIS385e-132 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 385 bits (991), Expect = e-132
Identities = 128/370 (34%), Positives = 196/370 (52%), Gaps = 27/370 (7%)

Query: 166 KLEKQALQSQE--PSSFNHSSDSEVEMIGQSPAMLAMKNELKVVASTDLNVLILGDTGTG 223
+ +AL + PS S + ++G+S AM + L + TDL ++I G++GTG
Sbjct: 113 GIIGRALAEPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTG 172

Query: 224 KELVAKSIHQGSPRSSKSLVYLNCAALPESVAESELFGHVKGAFTGAISHRSGKFEIADK 283
KELVA+++H R + V +N AA+P + ESELFGH KGAFTGA + +G+FE A+
Sbjct: 173 KELVARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQTRSTGRFEQAEG 232

Query: 284 GTLFLDEIGELPLSLQSKLLRVLQYGDLQKVGSDKSLKVDVRIIAATNKDLKQEVLAGRF 343
GTLFLDEIG++P+ Q++LLRVLQ G+ VG ++ DVRI+AATNKDLKQ + G F
Sbjct: 233 GTLFLDEIGDMPMDAQTRLLRVLQQGEYTTVGGRTPIRSDVRIVAATNKDLKQSINQGLF 292

Query: 344 RADLYHRLSVFPVIVPPLKEREGDIILLSGFFVERSRGKLGLKSLRLSPDSIKLLNSYDW 403
R DLY+RL+V P+ +PPL++R DI L FV+++ K GL R ++++L+ ++ W
Sbjct: 293 REDLYYRLNVVPLRLPPLRDRAEDIPDLVRHFVQQAE-KEGLDVKRFDQEALELMKAHPW 351

Query: 404 PGNVRELEHVLHRAAVLARAQAQSNIALITPQHFDFYNQQAKNIAAVPPSIGS------- 456
PGNVRELE+++ R L +IT + + + + + +
Sbjct: 352 PGNVRELENLVRRLTALYPQD------VITREIIENELRSEIPDSPIEKAAARSGSLSIS 405

Query: 457 -----------KSVLQSTKTEQTLKLATEAFQAQYIRQALAANGHNWAATARALDVDSGN 505
S + + I AL A N A L ++
Sbjct: 406 QAVEENMRQYFASFGDALPPSGLYDRVLAEMEYPLILAALTATRGNQIKAADLLGLNRNT 465

Query: 506 LHRLAKRIGI 515
L + + +G+
Sbjct: 466 LRKKIRELGV 475


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3447SHAPEPROTEIN290.030 Bacterial cell shape determinant MreB/Mbl protein s...
		>SHAPEPROTEIN#Bacterial cell shape determinant MreB/Mbl protein

signature.
Length = 347

Score = 29.0 bits (65), Expect = 0.030
Identities = 14/42 (33%), Positives = 25/42 (59%), Gaps = 2/42 (4%)

Query: 149 DVEVLPESLPAVLTTLMDSGVNEFTKSLVIDCGGTTLDMGVI 190
+V ++ E + A + + V+E T S+V+D GG T ++ VI
Sbjct: 137 EVFLIEEPMAAAIGAGLP--VSEATGSMVVDIGGGTTEVAVI 176


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3458PF05616300.007 Neisseria meningitidis TspB protein
		>PF05616#Neisseria meningitidis TspB protein

Length = 501

Score = 29.7 bits (66), Expect = 0.007
Identities = 18/41 (43%), Positives = 21/41 (51%), Gaps = 4/41 (9%)

Query: 130 GESEEYMRL---YKSFPEMKEHLESQ-YMLARESSSKLLGQ 166
G MRL Y FPE+KE +ESQ LAR KL +
Sbjct: 146 GVDSSIMRLMSDYSRFPEVKELMESQMERLARPYWEKLRNR 186


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3462FbpA_PF05833316e-04 Fibronectin-binding protein
		>FbpA_PF05833#Fibronectin-binding protein

Length = 577

Score = 31.4 bits (71), Expect = 6e-04
Identities = 13/52 (25%), Positives = 23/52 (44%), Gaps = 1/52 (1%)

Query: 54 KQKEQALVDQQKDQTKKLLKRNENLERKLAEAKGKDD-KETIAMLMAHIHEL 104
K K L + + K+++ L L + + KD K +L A+I+ L
Sbjct: 298 KSKSSDLQKIVMNNINRCTKKDKILNNTLKKCEDKDIFKLYGELLTANIYAL 349


49Spea_3517Spea_3525Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_3517215-0.612052metal-dependent hydrolase HDOD
Spea_3518215-0.254184peptidase S9 prolyl oligopeptidase
Spea_35196190.269832glutamine amidotransferase of anthranilate
Spea_35207210.336833hypothetical protein
Spea_35216210.561792TonB family protein
Spea_35227210.454129biopolymer transport protein ExbD/TolR
Spea_35235190.494176MotA/TolQ/ExbB proton channel
Spea_35245191.084868MotA/TolQ/ExbB proton channel
Spea_35252180.950354hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3521PF03544672e-15 Gram-negative bacterial tonB protein
		>PF03544#Gram-negative bacterial tonB protein

Length = 243

Score = 66.5 bits (162), Expect = 2e-15
Identities = 32/154 (20%), Positives = 54/154 (35%), Gaps = 1/154 (0%)

Query: 56 PEKPKIPTAKEVQSKPVTANAATPVSTSIPIMPTVADMPLQVPIMAVPTVNSLSLPSITP 115
P K ++ + KP + P S +
Sbjct: 86 PPKEAPVVIEKPKPKPKPKPKPVKKVEQPKRDVKPVESRPASPFENTAPARPTSSTATAA 145

Query: 116 VIAGIKDVDKAPELLRFIQPKMPLAGRKFKQGGRVLLRLIVEADGVVSQAEVLEAKPKQV 175
+ V P L QP+ P + + G+V ++ V DG V ++L AKP +
Sbjct: 146 TSKPVTSVASGPRALSRNQPQYPARAQALRIEGQVKVKFDVTPDGRVDNVQILSAKPANM 205

Query: 176 FDQSAIEAARKWRFKPAVLSGEAVKVFVDVPINF 209
F++ A R+WR++P G + V + IN
Sbjct: 206 FEREVKNAMRRWRYEPG-KPGSGIVVNILFKING 238


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3524RTXTOXIND330.002 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 33.3 bits (76), Expect = 0.002
Identities = 18/142 (12%), Positives = 52/142 (36%), Gaps = 10/142 (7%)

Query: 49 IRQQNSAWE---HQLKQEIDEVKSNQQELSARLASKRAQLAALNEQLVALNQ-QKQQLTG 104
I++Q S W+ +Q + +D+ ++ + + AR+ +L + +Q
Sbjct: 191 IKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSRVEKSRLDDFSSLLHKQAIA 250

Query: 105 SYQLAVDDMQLVQ-----GAYQKALSSLTQQWQQSSTSLIEVQRE-QSLAVAKASSSFPS 158
+ + + + V+ Y+ L + + + V + ++ + K + +
Sbjct: 251 KHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLRQTTDN 310

Query: 159 LSQLNELIGYAVDDMQMTAQVA 180
+ L + + Q + A
Sbjct: 311 IGLLTLELAKNEERQQASVIRA 332



Score = 31.0 bits (70), Expect = 0.011
Identities = 11/106 (10%), Positives = 36/106 (33%), Gaps = 10/106 (9%)

Query: 51 QQNSAWEHQLKQEIDEVKSNQQELSARLASKRAQLAALNEQLVALNQQ----KQQLTGSY 106
++ +K++ ++ + + L KRA+ + ++ K +L
Sbjct: 182 EEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSRVEKSRLDDFS 241

Query: 107 QLA----VDDMQLVQGAYQKALSSLTQQWQQSSTSLIEVQREQSLA 148
L + +++ + + + + L +++ E A
Sbjct: 242 SLLHKQAIAKHAVLE--QENKYVEAVNELRVYKSQLEQIESEILSA 285



Score = 29.4 bits (66), Expect = 0.031
Identities = 15/75 (20%), Positives = 30/75 (40%), Gaps = 9/75 (12%)

Query: 34 NYLQQKAQIDNRVADIRQQNSAWEHQLKQEIDEVKSN--------QQELSARLASKRAQL 85
L+Q+ + V ++R S E Q++ EI K + E+ +L +
Sbjct: 253 AVLEQENKYVEAVNELRVYKSQLE-QIESEILSAKEEYQLVTQLFKNEILDKLRQTTDNI 311

Query: 86 AALNEQLVALNQQKQ 100
L +L +++Q
Sbjct: 312 GLLTLELAKNEERQQ 326


50Spea_3634Spea_3643Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_36342160.099760major facilitator transporter
Spea_36351181.59339823S rRNA methyluridine methyltransferase
Spea_36361243.182530TOBE domain-containing protein
Spea_36374284.526111hypothetical protein
Spea_36384284.764213hypothetical protein
Spea_36392275.316494hypothetical protein
Spea_36402285.331532ABC transporter-like protein
Spea_36412285.160880ABC transporter-like protein
Spea_36421274.344737binding-protein-dependent transport system inner
Spea_3643-1193.086027binding-protein-dependent transport system inner
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3634TCRTETA290.029 Tetracycline resistance protein signature.
		>TCRTETA#Tetracycline resistance protein signature.

Length = 399

Score = 29.0 bits (65), Expect = 0.029
Identities = 34/159 (21%), Positives = 60/159 (37%), Gaps = 5/159 (3%)

Query: 24 AIASGFLMSLIPLSLASFGMDSSLVA---WLASIFYLGILVGTTCIQNIVAKVGHRFSLI 80
A+ G +M ++P L + + A L +++ L + + + G R L+
Sbjct: 18 AVGIGLIMPVLPGLLRDLVHSNDVTAHYGILLALYALMQFACAPVLGALSDRFGRRPVLL 77

Query: 81 LFLAMLTLTIVAMLVIPTATVWLIARFIAGFAVAGVFVVVESWLLMADSAKQRAKRLGLY 140
+ LA + M P V I R +AG A V +++ +RA+ G
Sbjct: 78 VSLAGAAVDYAIMATAPFLWVLYIGRIVAGITGA-TGAVAGAYIADITDGDERARHFGFM 136

Query: 141 MTSLYGGSALGQLAIGPLG-VNGNTPFYWVIGLLMLAIL 178
G G + G +G + + PF+ L L L
Sbjct: 137 SACFGFGMVAGPVLGGLMGGFSPHAPFFAAAALNGLNFL 175


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3640PF05272310.002 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 31.2 bits (70), Expect = 0.002
Identities = 9/22 (40%), Positives = 14/22 (63%)

Query: 28 VLGLSGPSGVGKSSLASVLAGM 49
+ L G G+GKS+L + L G+
Sbjct: 598 SVVLEGTGGIGKSTLINTLVGL 619


51Spea_3681Spea_3714Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_3681024-3.989866hypothetical protein
Spea_3682025-5.053578hypothetical protein
Spea_3683128-6.504192hypothetical protein
Spea_3684230-3.554384hypothetical protein
Spea_3685231-3.629831NERD domain-containing protein
Spea_3686023-1.620736hypothetical protein
Spea_36872231.342511hypothetical protein
Spea_36882232.225679hypothetical protein
Spea_36890233.510685chaperonin GroEL
Spea_3690-1264.505066co-chaperonin GroES
Spea_3691-1284.509451MATE efflux family protein
Spea_36920253.779100pentapeptide repeat-containing protein
Spea_36930243.506070hypothetical protein
Spea_3694-1243.244051LysR family transcriptional regulator
Spea_3695-1233.052073RND family efflux transporter MFP subunit
Spea_36960213.565915acriflavin resistance protein
Spea_36972213.895171hypothetical protein
Spea_36982213.831041hypothetical protein
Spea_36993203.786776hypothetical protein
Spea_37002203.961380hypothetical protein
Spea_37012193.760327hypothetical protein
Spea_37023182.610088PAS/PAC sensor hybrid histidine kinase
Spea_37031120.933097PhoH family protein
Spea_37041110.482242ATP-dependent helicase HepA
Spea_3705115-1.002508hypothetical protein
Spea_3706016-1.733281transposase
Spea_3707116-1.568560integrase catalytic subunit
Spea_3708115-0.682756hypothetical protein
Spea_37092210.890792enoyl-CoA hydratase
Spea_37104211.896804MCP methylation inhibitor CheC
Spea_37112202.327599diguanylate cyclase
Spea_37122192.747535hypothetical protein
Spea_37130182.4135391-acyl-sn-glycerol-3-phosphate acyltransferase
Spea_37142141.608069ABC-3 protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3691SECFTRNLCASE300.015 Bacterial translocase SecF protein signature.
		>SECFTRNLCASE#Bacterial translocase SecF protein signature.

Length = 333

Score = 30.2 bits (68), Expect = 0.015
Identities = 25/140 (17%), Positives = 60/140 (42%), Gaps = 15/140 (10%)

Query: 169 MMLAALINLILDPLLIFGIGPFPRLEIEGAAIATVISWVVALSLSTHLLIFKRHLVDFVE 228
L A++ L+ D LL G+ +L+ + +A +++ + S++ +++F R +
Sbjct: 178 FALGAVVALVHDVLLTVGLFAVLQLKFDLTTVAALLT-ITGYSINDTVVVFDR-----LR 231

Query: 229 PNIKRLKCNWKQLAHIAQPAAMMNLLNPLANAIIMAMLARIDHSAVAAFGAGT--RLESV 286
N+ + K L + +++ L+ ++ M + + +G
Sbjct: 232 ENLIKYK--TMPLRDVMN----LSVNETLSRTVMTGMTTLLALVPMLIWGGDVIRGFVFA 285

Query: 287 MLIAVMALSSSLVPFVAQNL 306
M+ V + S V +VA+N+
Sbjct: 286 MVWGVFTGTYSSV-YVAKNI 304


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3692NUCEPIMERASE310.003 Nucleotide sugar epimerase signature.
		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

Length = 334

Score = 30.9 bits (70), Expect = 0.003
Identities = 21/95 (22%), Positives = 36/95 (37%), Gaps = 8/95 (8%)

Query: 2 HAVDQIFNDEDFSDQDLQDARFERCSFYHCRFNHADLTDAEFIQCKFIVPGEDEGCDF-- 59
H V I N D+ D L+ AR E + +F+ DL D E + F +
Sbjct: 25 HQVVGIDNLNDYYDVSLKQARLELLAQPGFQFHKIDLADREGMTDLFASGHFERVFISPH 84

Query: 60 ----SYATLTSASFKHCNL--SMALFKGARCYGLE 88
Y+ ++ NL + + +G R ++
Sbjct: 85 RLAVRYSLENPHAYADSNLTGFLNILEGCRHNKIQ 119


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3695RTXTOXIND484e-08 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 47.5 bits (113), Expect = 4e-08
Identities = 23/182 (12%), Positives = 64/182 (35%), Gaps = 29/182 (15%)

Query: 104 EADYELAKADFKRKGELLRRELISQAEYDLASAQLKSS--KANLASAQDQLSYTELTAPY 161
E++ AK +++ +L + E++ + L LA +++ + + AP
Sbjct: 279 ESEILSAKEEYQLVTQLFKNEILDK----LRQTTDNIGLLTLELAKNEERQQASVIRAPV 334

Query: 162 DGTVAKISI-DNYQMVQANQPVL-VLQKDSDIDVVIQVPESLASKVTQFNPNAITQPV-V 218
V ++ + +V + ++ ++ +D ++V V + Q +
Sbjct: 335 SVKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFINV------GQNAII 388

Query: 219 RFANDPSSSYAALLKEHATQVTPGT-------QSYEVVFTLPRPA------NMTVLPGMS 265
+ P + Y L+ + + + V+ ++ N+ + GM+
Sbjct: 389 KVEAFPYTRYGYLVGK-VKNINLDAIEDQRLGLVFNVIISIEENCLSTGNKNIPLSSGMA 447

Query: 266 AE 267

Sbjct: 448 VT 449



Score = 34.8 bits (80), Expect = 5e-04
Identities = 18/83 (21%), Positives = 31/83 (37%), Gaps = 7/83 (8%)

Query: 78 EGQQVNKGAVLARLDRRDSQNTLLNREADYELAKADFKRKGELLR-------RELISQAE 130
EG+ V KG VL +L ++ L ++ A+ + R L R EL E
Sbjct: 114 EGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDE 173

Query: 131 YDLASAQLKSSKANLASAQDQLS 153
+ + + ++Q S
Sbjct: 174 PYFQNVSEEEVLRLTSLIKEQFS 196


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3696ACRIFLAVINRP488e-158 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 488 bits (1259), Expect = e-158
Identities = 210/1045 (20%), Positives = 439/1045 (42%), Gaps = 45/1045 (4%)

Query: 4 AEYSITHKVISWMFALLLLVGGSISFFSLGQLEFPEFTIKQALVVTAYPGASPEQVEEEV 63
A + I + +W+ A++L++ G+++ L ++P V YPGA + V++ V
Sbjct: 2 ANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDTV 61

Query: 64 TLPLEDALQQLDGIKHITSV-NSAGLSQIEIEIKENYDASELPQVWDEVRRKINDKAVEL 122
T +E + +D + +++S +SAG I + + D +V+ K+ L
Sbjct: 62 TQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTD---PDIAQVQVQNKLQLATPLL 118

Query: 123 PPGVHAPSVIDDFGD---VYGILLNVSGDGYSDRELQNYADF-LRRELVLVDGIKKVTIA 178
P V + + + G + ++ +Y ++ L ++G+ V +
Sbjct: 119 PQEVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLF 178

Query: 179 GIVNEQVVVEISQQKLNALGLDQNYIYGLINSQNVVSNAGSMLVGDN------RIRIHPT 232
G + + + LN L + + QN AG + I
Sbjct: 179 G-AQYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQ 237

Query: 233 GEFDNVRQMERLIISPPGSAKLIYLGDIAKIYKDTEETPSNIYHASGNKALSIGIAFSSG 292
F N + ++ + ++ L D+A++ + E + I +G A +GI ++G
Sbjct: 238 TRFKNPEEFGKVTLRVNSDGSVVRLKDVARV-ELGGENYNVIARINGKPAAGLGIKLATG 296

Query: 293 VNVVKVGEAVNERMSELNSELPIGMALDTVYDQSKMVDQTVNGFLVNLAESIAIVIGVLL 352
N + +A+ +++EL P GM + YD + V +++ + L E+I +V V+
Sbjct: 297 ANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMY 356

Query: 353 VFMG-VRSGLLMGLVLLLTILGTFIMMNVLNIELQIISLGALIIALGMLVDNAIVVTEGI 411
+F+ +R+ L+ + + + +LGTF ++ + +++ +++A+G+LVD+AIVV E +
Sbjct: 357 LFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENV 416

Query: 412 L-IGIKRGQTRLETAKQVISQTQWPLLGATIIAIIAFAPIGLSDNATGEFCASLFQVLLI 470
+ ++ E ++ +SQ Q L+G ++ F P+ +TG ++
Sbjct: 417 ERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVS 476

Query: 471 SLFISWITAMTLTPFFCNLMFKDGIVSDDENDDPYKGW-------LFGLYRHSLNYAMRF 523
++ +S + A+ LTP C + K EN + GW Y +S+ +
Sbjct: 477 AMALSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGS 536

Query: 524 RGLTLTLVVAALITSVIGFGYVKNVFFPASNTPMFFVDVWMPEGSDIKATERLLSRIETD 583
G L + + V+ F + + F P + +F + +P G+ + T+++L ++
Sbjct: 537 TGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDY 596

Query: 584 LLEQQKTTDTGLVNLTTVIGQG-AQRFVLSYVPEKGYK-AYGQILLEMTDLQALNKYMRL 641
L+ +K + + G AQ +++V K ++ G + M L
Sbjct: 597 YLKNEKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAK--MEL 654

Query: 642 LERELSLKFPEAEYRFKYMENGPSPAAKIEARFFGEDPQVLRQLAAQAETILKAEPTAV- 700
+ P + ++ + G L Q Q + P ++
Sbjct: 655 GKIRDGFVIPFNMPAIVELGTATGFDFELIDQA-GLGHDALTQARNQLLGMAAQHPASLV 713

Query: 701 GVRHNWRNQVTLVRPQLAQAQARETGISKQDLDTALLTNFSGQQIGTYRENSHLLPIIAR 760
VR N + ++ Q +A+ G+S D++ + T G + + + + + +
Sbjct: 714 SVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQ 773

Query: 761 APAEERLDAQSIWKLQVWSRDNNTFVPVTQVVSDFSTEWEDPLIMRRDRKRVISVLADPI 820
A A+ R+ + + KL V S N VP + + P + R + + + +
Sbjct: 774 ADAKFRMLPEDVDKLYVRSA-NGEMVPFSAFT-TSHWVYGSPRLERYNGLPSMEIQGEAA 831

Query: 821 NGAD-ETADSVFRKIKADIEAIPLPAGYELEWGGEYETSMEAQESVFSSIPLGYLAMFLI 879
G A ++ + + LPAG +W G + + + + ++ +FL
Sbjct: 832 PGTSSGDAMALMENLASK-----LPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLC 886

Query: 880 TVLLFNSVRQPLVIWFTVPLALIGVVSGLLLFDAPFSFMALLGLLSLTGMIIKNGIVLVD 939
L+ S P+ + VPL ++GV+ LF+ ++GLL+ G+ KN I++V+
Sbjct: 887 LAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVE 946

Query: 940 QIN-LELSQGKEAYQAVVDSAVSRVRPVLMAAITTMLGMLPLLSDAFFGS-----MAITI 993
L +GK +A + + R+RP+LM ++ +LG+LPL GS + I +
Sbjct: 947 FAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGV 1006

Query: 994 IFGLGFASVLTLIVLPVTYTLAFRI 1018
+ G+ A++L + +PV + + R
Sbjct: 1007 MGGMVSATLLAIFFVPVFFVVIRRC 1031


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3702HTHFIS788e-17 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 77.9 bits (192), Expect = 8e-17
Identities = 29/112 (25%), Positives = 48/112 (42%), Gaps = 2/112 (1%)

Query: 1108 DAGYVLLVEDNFINQQVATELLKSAGYTVDVAENGQIALDMLDKAKYDAVLMDIQMPVMD 1167
+L+ +D+ + V + L AGY V + N + D V+ D+ MP +
Sbjct: 2 TGATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDEN 61

Query: 1168 GLTATKELRKRYPVDELPVIAMTAHAMSGDREKSLAAGMNAHITKPIVLTEL 1219
++K P +LPV+ M+A K+ G ++ KP LTEL
Sbjct: 62 AFDLLPRIKKARP--DLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTEL 111



Score = 62.5 bits (152), Expect = 6e-12
Identities = 19/110 (17%), Positives = 46/110 (41%), Gaps = 10/110 (9%)

Query: 968 KTLVIDDNPTALQIYSSVMRDFHFNVDTAASGPEGLYKLSKNPVDLLLLDWMMPEMDGVE 1027
LV DD+ + + + ++V ++ ++ DL++ D +MP+ + +
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64

Query: 1028 VIKQIDQMVADGRLEKRPIIIMMTAYTAEPMQKDVEA--ANVFALLQKPF 1075
++ +I + P+++ M+A ++A + L KPF
Sbjct: 65 LLPRIKK-----ARPDLPVLV-MSAQNTFMTA--IKASEKGAYDYLPKPF 106


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3710HTHFIS672e-14 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 67.2 bits (164), Expect = 2e-14
Identities = 28/112 (25%), Positives = 47/112 (41%), Gaps = 1/112 (0%)

Query: 5 ILICDDSALARKQMARTLPKDWDVDITYATNGLEGMEAIREGKGEVVFLDLNMPVMDGYQ 64
IL+ DD A R + + L D+ +N I G G++V D+ MP + +
Sbjct: 6 ILVADDDAAIRTVLNQAL-SRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64

Query: 65 VLEAIQKEDLPALVIVVSGDIQIKAHERVRSLGALDFIQKPVSADAISHILQ 116
+L I+K V+V+S + GA D++ KP + I+
Sbjct: 65 LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIG 116


52Spea_3742Spea_3747Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_37420133.177163Ig domain-containing protein
Spea_37432194.247998ABC-2 type transporter
Spea_37440194.037866ABC-2 type transporter
Spea_37451183.831951secretion protein HlyD family protein
Spea_37461183.573628outer membrane efflux protein
Spea_37470173.217323peptidase U62 modulator of DNA gyrase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3742INTIMIN398e-05 Intimin signature.
		>INTIMIN#Intimin signature.

Length = 939

Score = 39.3 bits (91), Expect = 8e-05
Identities = 51/251 (20%), Positives = 90/251 (35%), Gaps = 28/251 (11%)

Query: 279 NELATTLPLEADKYTVSAGGTFGVTADLATKNDDGSYTRLQTPTSVSFSSSCVSSNSASI 338
N + T+ + ++ V G TAD + DG+ + + + A++
Sbjct: 540 NNVLLTITVLSNGQVVDQVGVTDFTADKTSAKADGT-----EAITYTATVKKNGVAQANV 594

Query: 339 DSPVTTLSGTA--SSTFQNTSCSG------NSERNDQIIASVVAGNQTLTAELDFS-LAS 389
+SGTA S+ NT+ SG S++ Q++ S T +
Sbjct: 595 PVSFNIVSGTAVLSANSANTNGSGKATVTLKSDKPGQVVVSAKTAEMTSALNANAVIFVD 654

Query: 390 QTLANLSFISAEPTSIRIKGAGGTNSSKSSLITFKV-ADANGQPIAQQDVDFSLDTSVGG 448
QT A+++ I A+ T+ ++ IT+ V +P++ Q+V F+
Sbjct: 655 QTKASITEIKADKTTA--------VANGQDAITYTVKVMKGDKPVSNQEVTFTTTLGKLS 706

Query: 449 IKFANGDTNTSNTSNSAGLVSTTVLSGTVPTPVRVLASATANGESVTTQSEQLTINTGLP 508
+ +N L STT V RV A LTI+ G
Sbjct: 707 NS---TEKTDTNGYAKVTLTSTTPGKSLV--SARVSDVAVDVKAPEVEFFTTLTIDDGNI 761

Query: 509 QQLGFSLSSSL 519
+ +G + L
Sbjct: 762 EIVGTGVKGKL 772


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3745RTXTOXIND416e-06 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 40.6 bits (95), Expect = 6e-06
Identities = 22/155 (14%), Positives = 45/155 (29%), Gaps = 27/155 (17%)

Query: 45 ISSKVPGRVEEVLVRRGDKVNEGDLL---------YAIYSPELKAKLMQAEGGRDAALAM 95
I V+E++V+ G+ V +GD+L + + E R L+
Sbjct: 99 IKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSR 158

Query: 96 QQEADNGARKQQIAASKEQWLKAQAAAKLARTTFDRVEVLFNEGVLARQKRDEAFTQWQA 155
E + ++ E + + + ++ R E F+ WQ
Sbjct: 159 SIELNK---LPELKLPDEPYFQNVSEEEVLR---------------LTSLIKEQFSTWQN 200

Query: 156 AKYTEQAALAMYQMADEGARVETKAAAAGNARMAE 190
KY ++ L + +
Sbjct: 201 QKYQKELNLDKKRAERLTVLARINRYENLSRVEKS 235


53Spea_3853Spea_3869Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_38532221.501629GntR family transcriptional regulator
Spea_38543211.921612LysR family transcriptional regulator
Spea_38554242.530450D-galactarate dehydratase/Altronate hydrolase
Spea_38563243.030924D-galactarate dehydratase
Spea_38573243.155957putative transporter
Spea_38583243.307940mandelate racemase/muconate lactonizing protein
Spea_38592212.789187cytochrome C family protein
Spea_38602212.389459hypothetical protein
Spea_38613161.512004anaerobic dimethyl sulfoxide reductase subunit
Spea_38623151.032053dimethylsulfoxide reductase subunit B
Spea_38632120.926534hypothetical protein
Spea_38642152.704085cytoplasmic chaperone TorD family protein
Spea_38652152.666725hypothetical protein
Spea_38661152.860671TetR family transcriptional regulator
Spea_38672143.114797OPT family oligopeptide transporter
Spea_38682162.911209OmpA/MotB domain-containing protein
Spea_38692162.963071outer membrane adhesin-like protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3866HTHTETR671e-15 TetR bacterial regulatory protein HTH signature.
		>HTHTETR#TetR bacterial regulatory protein HTH signature.

Length = 215

Score = 66.6 bits (162), Expect = 1e-15
Identities = 25/137 (18%), Positives = 56/137 (40%), Gaps = 7/137 (5%)

Query: 3 RRDREVKLLDIARELILEYGMVSFKFTDIAKRAEVSRATLYKYFSGKEDVLVSLFVHDAE 62
++ +LD+A L + G+ S +IAK A V+R +Y +F K D+ ++
Sbjct: 9 AQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSES 68

Query: 63 NTKQMLVDIQADLTLNNREKILLSLLAPVASSMETLNRSGTLLLSANPGIFMYASDKQQA 122
N ++ ++ QA + + L+ + S++ R + ++ +
Sbjct: 69 NIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLM-------EIIFHKCEFVG 121

Query: 123 RLEQIVSEIRQITLEFW 139
+ + R + LE +
Sbjct: 122 EMAVVQQAQRNLCLESY 138


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3868OMPADOMAIN1221e-33 OMPA domain signature.
		>OMPADOMAIN#OMPA domain signature.

Length = 346

Score = 122 bits (307), Expect = 1e-33
Identities = 88/401 (21%), Positives = 136/401 (33%), Gaps = 111/401 (27%)

Query: 22 VVQAAENESQQTEHMWSQGWYLGGQFGLATTNVSNAGLDELYEQAGIDASSTKVDDSGAS 81
V QAA ++ WY G + G + Y G ++ ++
Sbjct: 18 VAQAAPKDNT---------WYTGAKLGWSQ-----------YHDTGFINNNGPTHENQLG 57

Query: 82 YGLFLGYKFNQYFSVEAGYLDLGERSVEFSGQTTDLDAYYDLAEHVYPETGDGWSLSVLG 141
G F GY+ N Y E GY LG + S + A G L+
Sbjct: 58 AGAFGGYQVNPYVGFEMGYDWLGRMPYKGSVENGAYKAQ-------------GVQLTAKL 104

Query: 142 TYPLSERFSVTGKLGYFAWELDAVTSSIADEASQVGSDSHSGSGVWLGAELGYQINHDMQ 201
YP+++ + +LG W D +++ G + +G + Y I ++
Sbjct: 105 GYPITDDLDIYTRLGGMVWRADT-------KSNVYGKNHDTGVSPVFAGGVEYAITPEIA 157

Query: 202 AYVSYQHMPLDADE--------VGVFALGLRYWFGSDSRDAAPVLPAAVVPTLAKIGSDG 253
+ YQ D G+ +LG+ Y FG +AAPV+ A P
Sbjct: 158 TRLEYQWTNNIGDAHTIGTRPDNGMLSLGVSYRFGQG--EAAPVVAPAPAP--------- 206

Query: 254 DSDSDGVFNAQDQCLDTPSTHAVDSRGCTLFAPRVVEMKLT----VLYENDSDKIDLSNT 309
AP V T VL+ + +
Sbjct: 207 -------------------------------APEVQTKHFTLKSDVLFNFNKATLKPEGQ 235

Query: 310 DKIQKLADFIEQYDIK--QITVFGHTSAVGSQAYNQKLSERRAASVAEMLAADFNIATGI 367
+ +L + D K + V G+T +GS AYNQ LSERRA SV + L + I
Sbjct: 236 AALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGLSERRAQSVVDYLISK-GIPADK 294

Query: 368 IKAVGKGESEPIS--------------HIPEQNRRIEVYLN 394
I A G GES P++ +RR+E+ +
Sbjct: 295 ISARGMGESNPVTGNTCDNVKQRAALIDCLAPDRRVEIEVK 335


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3869CHLAMIDIAOM6320.044 Chlamydia cysteine-rich outer membrane protein 6 si...
		>CHLAMIDIAOM6#Chlamydia cysteine-rich outer membrane protein 6

signature.
Length = 547

Score = 32.4 bits (73), Expect = 0.044
Identities = 39/155 (25%), Positives = 59/155 (38%), Gaps = 31/155 (20%)

Query: 936 VEVTIELSNTGTAPAYDVVLTDVLNANLFDVTSALEATTPANFSYSFVSPTVTYTTSSAI 995
VE I +SN G DVV+ D L+ + + LEA +S T +
Sbjct: 333 VEYVISVSNPGDLVLRDVVVEDTLSPGV----TVLEAAGAQ------ISCNKVVWTVKEL 382

Query: 996 APGQSLTFSYTANVKQGVVTGSSYDNNVSVVGDSQQGDISNPDRDSNDSATPTAAIGSLA 1055
PG+SL + + T + NNV V S G ++ A T +A
Sbjct: 383 NPGESLQYKVLVRAQ----TPGQFTNNVVVKSCSDCGTCTS-------CAEATTYWKGVA 431

Query: 1056 ISELVLIDSTESWTSDAVDGVEAAIGETLTYRLTV 1090
+ + ++D T D V +GE YR+ V
Sbjct: 432 ATHMCVVD-----TCDPV-----CVGENTVYRICV 456


54Spea_3881Spea_3902Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_3881-1173.161062tRNA guanosine-2'-O-methyltransferase
Spea_3882-1163.026625AMP-dependent synthetase and ligase
Spea_3883-1173.271185CaCA family Na(+)/Ca(+) antiporter
Spea_3884-1183.324454ATP-dependent DNA helicase RecG
Spea_3885-2202.203964hypothetical protein
Spea_3886-1223.077050hypothetical protein
Spea_3887-1232.731063phospholipid/glycerol acyltransferase
Spea_3888-1223.082289acyl carrier protein
Spea_3889-1213.909919acyl carrier protein
Spea_3890-2214.012618hypothetical protein
Spea_3891-1213.846137hypothetical protein
Spea_38920223.668933beta-hydroxyacyl-(acyl-carrier-protein)
Spea_38930233.791166glycosyl transferase family protein
Spea_38941223.634336histidine ammonia-lyase
Spea_38952243.6094814-hydroxybenzoyl-CoA thioesterase
Spea_38963253.662659outer membrane lipoprotein carrier protein LolA
Spea_38972254.001201hypothetical protein
Spea_38980234.649796tryptophan halogenase
Spea_38991224.545577hypothetical protein
Spea_39002214.4493603-oxoacyl-ACP synthase
Spea_39011193.792689beta-hydroxyacyl-(acyl-carrier-protein)
Spea_3902-1163.1566653-ketoacyl-ACP reductase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3884SECA412e-05 SecA protein signature.
		>SECA#SecA protein signature.

Length = 901

Score = 40.6 bits (95), Expect = 2e-05
Identities = 31/84 (36%), Positives = 41/84 (48%), Gaps = 8/84 (9%)

Query: 294 MRLVQGDV-----GSGKTLVAALAA-LQAIESGYQVAMMAPTELLAEQHAINFKSWFEPL 347
M L + + G GKTL A L A L A+ +G V ++ + LA++ A N + FE L
Sbjct: 92 MVLNERCIAEMRTGEGKTLTATLPAYLNAL-TGKGVHVVTVNDYLAQRDAENNRPLFEFL 150

Query: 348 GLKVGW-LAGKLKGKARAQSLADI 370
GL VG L G R ADI
Sbjct: 151 GLTVGINLPGMPAPAKREAYAADI 174


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3885TONBPROTEIN336e-04 Gram-negative bacterial tonB protein signature.
		>TONBPROTEIN#Gram-negative bacterial tonB protein signature.

Length = 239

Score = 33.4 bits (76), Expect = 6e-04
Identities = 21/92 (22%), Positives = 31/92 (33%), Gaps = 11/92 (11%)

Query: 36 GYYYLSGNEKIEEPQIIAPVVI-----------PDPVPEQPLETEAVPEPEIVEAVPVQL 84
G Y S ++ IE P P+ + P E PEPE + P +
Sbjct: 26 GLLYTSVHQVIELPAPAQPISVTMVTPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEA 85

Query: 85 PEVEPVPEVEPLPALADSDTYVQQKVIEVADG 116
P V P+ +P P +Q +V
Sbjct: 86 PVVIEKPKPKPKPKPKPVKKVQEQPKRDVKPV 117


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3897ACRIFLAVINRP429e-06 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 42.1 bits (99), Expect = 9e-06
Identities = 29/145 (20%), Positives = 57/145 (39%), Gaps = 25/145 (17%)

Query: 668 LLALALLVAGIIFTFRFGAKLAAIV-VAVPA--LSALLTLACLGITHNPLTLFHALALIL 724
L +LV +++ F + I +AVP L LA G + N LT+F ++L
Sbjct: 344 LFEAIMLVFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMF---GMVL 400

Query: 725 VFGIGVDYSL----------------FFAESKQQTRGVMMAVFMSAVSTLLAFGLLAF-- 766
G+ VD ++ +++ + A+ A+ F +AF
Sbjct: 401 AIGLLVDDAIVVVENVERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFG 460

Query: 767 -SQTPAINAFGLTLLLGISFTFLLS 790
S F +T++ ++ + L++
Sbjct: 461 GSTGAIYRQFSITIVSAMALSVLVA 485



Score = 35.2 bits (81), Expect = 0.001
Identities = 45/221 (20%), Positives = 86/221 (38%), Gaps = 23/221 (10%)

Query: 212 AIVMAKGSDSAFNPKAQQSQLAALQTAFHSVNQQDADIEIIKAGALFHAAAATENAKQEV 271
I +A G+++ KA +++LA LQ F Q + + + + EV
Sbjct: 290 GIKLATGANALDTAKAIKAKLAELQPFF----PQGMKVLY-----PYDTTPFVQLSIHEV 340

Query: 272 SSIGLLSLIGVITLVWLAFRSFMPLTIAVITVSTSLLFAVVMTTLLFGELHLLTLVFGTS 331
+++ V +++L ++ I I V LL + ++ LT+
Sbjct: 341 VKTLFEAIMLVFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVL 400

Query: 332 LIGISIDYCFHYY--CERLHH-----PSDSSEKVIQKIFAAITLALVTSVIAYSAIGIAP 384
IG+ +D ER+ P +++EK + +I A+ + + I +A
Sbjct: 401 AIGLLVDDAIVVVENVERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVF--IPMAF 458

Query: 385 FPG-----MQQVAVFCASGLVGAYLTLLLAYPTLAARPLKE 420
F G +Q ++ S + + L L+ P L A LK
Sbjct: 459 FGGSTGAIYRQFSITIVSAMALSVLVALILTPALCATLLKP 499


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3902DHBDHDRGNASE1035e-29 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase sig...
		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

signature.
Length = 261

Score = 103 bits (259), Expect = 5e-29
Identities = 69/250 (27%), Positives = 115/250 (46%), Gaps = 15/250 (6%)

Query: 3 KRVLITGSSRGIGKAIALKLAASGFDIAMHFHSNQIAADATKAELQQLGIKVSCLQFDIA 62
K ITG+++GIG+A+A LA+ G I N + + L+ D+
Sbjct: 9 KIAFITGAAQGIGEAVARTLASQGAHI-AAVDYNPEKLEKVVSSLKAEARHAEAFPADVR 67

Query: 63 ARAAVKQAIEQDIEQHGAYYGVVLNAGINADTAFPAMTESEWDSVVHTNLDGFYNVIHPT 122
AA+ + + + G +V AG+ ++++ EW++ N G +N +
Sbjct: 68 DSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASR-S 126

Query: 123 VMPMVQGRQGGRIITLASVSGIAGNRGQVNYSASKAGIIGATKALSLELAKRKITVNCIA 182
V + R+ G I+T+ S Y++SKA + TK L LELA+ I N ++
Sbjct: 127 VSKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEYNIRCNIVS 186

Query: 183 PGLIETDM-----VSDIPKEMV--------NTIVPMRRMGKPSEIAGLANYLMSEDAAYI 229
PG ETDM + E V T +P++++ KPS+IA +L+S A +I
Sbjct: 187 PGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQAGHI 246

Query: 230 TRQVISVNGG 239
T + V+GG
Sbjct: 247 TMHNLCVDGG 256


55Spea_3917Spea_3949Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_39172170.637854sodium:dicarboxylate symporter
Spea_39180201.555994hypothetical protein
Spea_39190192.203211XRE family transcriptional regulator
Spea_39200172.318956BNR repeat-containing glycosyl hydrolase
Spea_3921-2172.461410hypothetical protein
Spea_3922-2172.570112class V aminotransferase
Spea_3923-2172.102299hypothetical protein
Spea_3924-2182.038608AsnC family transcriptional regulator
Spea_3925-1183.224906iron-containing alcohol dehydrogenase
Spea_3926-1183.570778ThiJ/PfpI domain-containing protein
Spea_3927-1183.192596hypothetical protein
Spea_3928-1193.548685hypothetical protein
Spea_39290203.695452signal transduction histidine kinase, nitrogen
Spea_39301204.119213nitrogen metabolism transcriptional regulator
Spea_39311192.970556cation diffusion facilitator family transporter
Spea_39320141.532513hypothetical protein
Spea_39330151.396851two component transcriptional regulator
Spea_3934-1151.407838histidine kinase
Spea_39350141.250944regulatory protein TetR
Spea_39361151.413035LysR family transcriptional regulator
Spea_39370172.247074hypothetical protein
Spea_3938-1173.147323tetraheme cytochrome c
Spea_3939-1183.424301flavocytochrome c
Spea_3940-2213.784861LysR family transcriptional regulator
Spea_3941-2223.850275quinone oxidoreductase
Spea_3942-2233.461367aldehyde dehydrogenase
Spea_3943-2233.188686hypothetical protein
Spea_3944-2232.941288radical SAM domain-containing protein
Spea_3945-1222.369157LysR family transcriptional regulator
Spea_3946-1191.773756RNA methyltransferase
Spea_39470191.733140peptidase M16 domain-containing protein
Spea_39481180.704048peptidase M16 domain-containing protein
Spea_3949219-0.044121type IV pilus assembly PilZ
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3922ADHESNFAMILY290.022 Adhesin family signature.
		>ADHESNFAMILY#Adhesin family signature.

Length = 309

Score = 29.4 bits (66), Expect = 0.022
Identities = 17/71 (23%), Positives = 27/71 (38%), Gaps = 4/71 (5%)

Query: 127 IPKSLDITDPAVWQSHIKA--DVDLVFVSHVYSNTGQLAPVNDIVEAAKSKAALTLIDVA 184
+P D + +K + DL+F + + TG A +VE AK V
Sbjct: 60 VPIGQDPHEYEPLPEDVKKTSEADLIFYNGINLETGGNAWFTKLVENAKKTENKDYFAV- 118

Query: 185 QSAGIVPLDLG 195
S G+ + L
Sbjct: 119 -SDGVDVIYLE 128


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3929PF06580452e-07 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 44.9 bits (106), Expect = 2e-07
Identities = 37/196 (18%), Positives = 70/196 (35%), Gaps = 39/196 (19%)

Query: 161 LNEFTDLIIEQADRLRNLVDRL-------LGPQKPTQHSLYNIHEVIQKVLKLVNVTLPD 213
LN LI+E + R ++ L L Q SL + V+ L+L ++ D
Sbjct: 179 LNNIRALILEDPTKAREMLTSLSELMRYSLRYSNARQVSLADELTVVDSYLQLASIQFED 238

Query: 214 NIELTQDYDPSIPDIEMDPDQLQQTILNIVQNAVQ-ALEPS--GGHIRLKTRTQHQVTIG 270
++ +P+I D+++ P +Q +V+N ++ + GG I LK +
Sbjct: 239 RLQFENQINPAIMDVQVPPMLVQT----LVENGIKHGIAQLPQGGKILLKGTKDNGT--- 291

Query: 271 TKRHKLVLMLSVIDDGPGIQPELMDTLFYPMVTGREQGSGLGLSIAHNFARLHGG---RI 327
+ L V + G ++ +G GL ++ G +I
Sbjct: 292 -------VTLEVENTGSLALKN------------TKESTGTGLQNVRERLQMLYGTEAQI 332

Query: 328 DCDSTVGHTEFTITLP 343
G + +P
Sbjct: 333 KLSEKQGKVNAMVLIP 348


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3930HTHFIS5690.0 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 569 bits (1467), Expect = 0.0
Identities = 205/474 (43%), Positives = 296/474 (62%), Gaps = 12/474 (2%)

Query: 5 VWILDDDSSIRWVLEKALQSAKFSSASFAAAESLWQALETAQPQVIVSDIRMPGTDGLTL 64
+ + DDD++IR VL +AL A + + A +LW+ + ++V+D+ MP + L
Sbjct: 6 ILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFDL 65

Query: 65 LERLQNHYPHIPVIIMTAHSDLDSAVSAYQAGAFEYLPKPFDIDEAISLVDRALTHAKEQ 124
L R++ P +PV++M+A + +A+ A + GA++YLPKPFD+ E I ++ RAL K +
Sbjct: 66 LPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKRR 125

Query: 125 SSTITTEEPIVATPEIIGEAPAMQEVFRAIGRLSRSSISVLINGQSGTGKELVASALHKH 184
S E+ ++G + AMQE++R + RL ++ ++++I G+SGTGKELVA ALH +
Sbjct: 126 PSK--LEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVARALHDY 183

Query: 185 SPRKGKPFIAINMAAIPKDLIESELFGHEKGAFTGAGSVRQGRFEQANGGTLFLDEIGDM 244
R+ PF+AINMAAIP+DLIESELFGHEKGAFTGA + GRFEQA GGTLFLDEIGDM
Sbjct: 184 GKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQTRSTGRFEQAEGGTLFLDEIGDM 243

Query: 245 PLDVQTRLLRVLADGQFYRVGGHSPVQVDVRIIAATHQNLEQRVHQGGFREDLFHRLNVI 304
P+D QTRLLRVL G++ VGG +P++ DVRI+AAT+++L+Q ++QG FREDL++RLNV+
Sbjct: 244 PMDAQTRLLRVLQQGEYTTVGGRTPIRSDVRIVAATNKDLKQSINQGLFREDLYYRLNVV 303

Query: 305 RVHLPPLSQRREDIPQLARHFLVIAAKEIGVEPKVLTKETANKLSQLPWPGNVRQLENTC 364
+ LPPL R EDIP L RHF+ A KE G++ K +E + PWPGNVR+LEN
Sbjct: 304 PLRLPPLRDRAEDIPDLVRHFVQQAEKE-GLDVKRFDQEALELMKAHPWPGNVRELENLV 362

Query: 365 RWLTVMASGQEILPLDLPPELLQEPKLSHAQSSDCDDWQGALKLFIDQRLSD-------- 416
R LT + I + EL E S + + ++ +++ +
Sbjct: 363 RRLTALYPQDVITREIIENELRSEIPDSPIEKAAARSGSLSISQAVEENMRQYFASFGDA 422

Query: 417 -GDSDLLTEVQPAFERILLETALKHTNGHKQEAAKRLGWGRNTLTRKLKELEMD 469
S L V E L+ AL T G++ +AA LG RNTL +K++EL +
Sbjct: 423 LPPSGLYDRVLAEMEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIRELGVS 476


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3933HTHFIS986e-26 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 98.4 bits (245), Expect = 6e-26
Identities = 36/136 (26%), Positives = 66/136 (48%), Gaps = 1/136 (0%)

Query: 2 SRILLVDDDLGLSELLAQLLELEGFKLTLAHDGQSGLDLAIEQQFDLILLDVMLPKLNGF 61
+ IL+ DDD + +L Q L G+ + + + + DL++ DV++P N F
Sbjct: 4 ATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAF 63

Query: 62 EVLRALRS-KKQTPVLMLTARGDEIDRVVGLEIGADDYLPKPFNDRELVARIRAIIRRTH 120
++L ++ + PVL+++A+ + + E GA DYLPKPF+ EL+ I +
Sbjct: 64 DLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPK 123

Query: 121 IQPSEAPQAIHQYGDI 136
+PS+ +
Sbjct: 124 RRPSKLEDDSQDGMPL 139


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3934PF06580372e-04 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 36.8 bits (85), Expect = 2e-04
Identities = 27/124 (21%), Positives = 48/124 (38%), Gaps = 14/124 (11%)

Query: 282 EADQLEQMIAELLELSRVKLNANENKRSLELAETLSQVLDDADFEAQQ----QQKQLHID 337
+ + +M+ L EL R L N R + LA+ L+ V D+ + + Q
Sbjct: 189 DPTKAREMLTSLSELMRYSL-RYSNARQVSLADELTVV--DSYLQLASIQFEDRLQFENQ 245

Query: 338 IDESI----VIPLYPRPLSRAVENLLRNAIRYANTQVSIQAMASASASGVQIEIIDDGPG 393
I+ +I V P+ + L VEN +++ I I + V +E+ + G
Sbjct: 246 INPAIMDVQVPPMLVQTL---VENGIKHGIAQLPQGGKILLKGTKDNGTVTLEVENTGSL 302

Query: 394 ISDE 397

Sbjct: 303 ALKN 306


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3935HTHTETR387e-06 TetR bacterial regulatory protein HTH signature.
		>HTHTETR#TetR bacterial regulatory protein HTH signature.

Length = 215

Score = 38.5 bits (89), Expect = 7e-06
Identities = 26/170 (15%), Positives = 52/170 (30%), Gaps = 9/170 (5%)

Query: 3 NWQQRESYLTDIAERCLRGHKSFDLRRSHLVEASQISKGTIYNHFPTEADLVVAVATAHY 62
Q+ ++ D+A R + +A+ +++G IY HF ++DL +
Sbjct: 8 EAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSE 67

Query: 63 RKRLERAA-IDDALYADYLTRFL-----MHHCWGLRDDLLYDRFIISRVMPNSELLQQVT 116
E D L+ + + II + V
Sbjct: 68 SNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQ 127

Query: 117 DENRAAFEQIYGEYIRWNRELIKAVGVVEGFN---RAELVGNYLRGALIN 163
R + Y + + I+A + A ++ Y+ G + N
Sbjct: 128 QAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMEN 177


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3939HTHFIS310.010 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 31.3 bits (71), Expect = 0.010
Identities = 11/31 (35%), Positives = 17/31 (54%), Gaps = 1/31 (3%)

Query: 39 KWDKEVEVLIIGSGFAGLAAAIEATRKGAKD 69
K ++ VL++ S AI+A+ KGA D
Sbjct: 71 KARPDLPVLVM-SAQNTFMTAIKASEKGAYD 100


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3941NUCEPIMERASE290.017 Nucleotide sugar epimerase signature.
		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

Length = 334

Score = 29.4 bits (66), Expect = 0.017
Identities = 11/27 (40%), Positives = 16/27 (59%)

Query: 151 VLVTGASGGVGSVAVTLLAQLGYRVVA 177
LVTGA+G +G L + G++VV
Sbjct: 3 YLVTGAAGFIGFHVSKRLLEAGHQVVG 29


56Spea_3962Spea_4028Y        Y        YPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_3962215-0.827424hypothetical protein
Spea_3963115-2.466612hypothetical protein
Spea_3964015-4.140650hypothetical protein
Spea_3965-115-4.820327polysulfide reductase NrfD
Spea_3966010-2.8834524Fe-4S ferredoxin
Spea_3967211-2.377421formate-dependent nitrite reductase
Spea_3968114-1.299646hypothetical protein
Spea_39692160.700461LysR family transcriptional regulator
Spea_39703182.030143LysR family transcriptional regulator
Spea_39713192.3915392-succinyl-5-enolpyruvyl-6-hydroxy-3-
Spea_39723181.542459alpha/beta hydrolase fold protein
Spea_39732161.470524O-succinylbenzoate synthase
Spea_39741121.200781o-succinylbenzoate--CoA ligase
Spea_39753160.978189hypothetical protein
Spea_39764141.281718transposase IS116/IS110/IS902 family protein
Spea_39774161.793480RNA polymerase factor sigma-32
Spea_39784161.747670hypothetical protein
Spea_39795181.347705cell division ATP-binding protein FtsE
Spea_39806200.724843signal recognition particle-docking protein
Spea_3981017-1.551470putative methyltransferase
Spea_3982121-2.115286hypothetical protein
Spea_39830171.284603NapC/NirT cytochrome c domain-containing
Spea_39840193.318547hypothetical protein
Spea_39851193.762854hypothetical protein
Spea_39861193.360171hypothetical protein
Spea_39870213.494866hypothetical protein
Spea_39880233.836377RND family efflux transporter MFP subunit
Spea_39891223.084413CzcA family heavy metal efflux protein
Spea_39901211.763111glyoxalase/bleomycin resistance
Spea_3991-1181.185868diguanylate cyclase
Spea_3992-1171.581963secretion protein HlyD family protein
Spea_3993-2131.249005major facilitator superfamily permease
Spea_3994-2101.299113AraC family transcriptional regulator
Spea_3995-1111.824466aromatic amino acid transporter
Spea_3996-1111.576204glycerol-3-phosphate acyltransferase
Spea_39972141.597737LexA repressor
Spea_39982151.306912hypothetical protein
Spea_39992151.140269cytochrome c oxidase subunit II
Spea_40002151.084485cytochrome c oxidase subunit I type
Spea_40012190.609963cytochrome C oxidase assembly protein
Spea_40022201.061191cytochrome c oxidase subunit III
Spea_40031161.414916hypothetical protein
Spea_40042171.949986hypothetical protein
Spea_40051141.801029cytochrome oxidase assembly
Spea_40060172.218979protoheme IX farnesyltransferase
Spea_4007-1182.476983electron transport protein SCO1/SenC
Spea_4008-1182.910803polysaccharide deacetylase
Spea_4009-1193.141712MATE efflux family protein
Spea_4010-1163.278396putative DNA uptake protein
Spea_4011-1183.459401peptidase M14 carboxypeptidase A
Spea_4012-1153.697958competence protein ComF
Spea_40130153.373424bioH protein
Spea_40140152.318917hypothetical protein
Spea_40150131.668185RNA-binding S1 domain-containing protein
Spea_4016-1140.785944transcription elongation factor GreB
Spea_4017-1100.218484osmolarity response regulator
Spea_4018-110-0.411624osmolarity sensor protein
Spea_401909-0.735676methyl-accepting chemotaxis sensory transducer
Spea_4020211-2.142127LysR family transcriptional regulator
Spea_4021311-3.133315hypothetical protein
Spea_4022512-3.031620arylsulfotransferase
Spea_4023313-3.463631DSBA oxidoreductase
Spea_4024413-2.949765disulfide bond formation protein DsbB
Spea_4025212-3.045119TetR family transcriptional regulator
Spea_4026210-1.564896hypothetical protein
Spea_40272100.062435arylsulfotransferase
Spea_40282161.547694DSBA oxidoreductase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3963OUTRSURFACE280.020 Outer surface protein signature.
		>OUTRSURFACE#Outer surface protein signature.

Length = 273

Score = 27.6 bits (61), Expect = 0.020
Identities = 19/61 (31%), Positives = 31/61 (50%), Gaps = 6/61 (9%)

Query: 31 SLLLEVVMADESMSEQEAKLL--PDLLTTTLNLSTDDVQSLISEAKRSQQKSTSLYEFTQ 88
S +LE D+S +AKL DL TT L +D ++L+S S+ K+++ F +
Sbjct: 73 SGVLEGTKDDKS----KAKLTIADDLSKTTFELFKEDGKTLVSRKVSSKDKTSTDEMFNE 128

Query: 89 A 89

Sbjct: 129 K 129


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3980IGASERPTASE649e-13 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 64.3 bits (156), Expect = 9e-13
Identities = 40/275 (14%), Positives = 80/275 (29%), Gaps = 10/275 (3%)

Query: 11 RKDKSKEEAQAAEAAKLEAEKLELERIEAERFEVERVAAEQAEAARIEAEQAEAQRLADE 70
+K + + ++ + + E+ RV E A +E E
Sbjct: 984 EVEKRNQTVDTTNITTPNNIQADVPSVPSNNEEIARVD-EAPVPPPAPATPSETTETVAE 1042

Query: 71 QAAQVEAQRLADEQAAQVEAQRVAAEQAEAQRLAGEQAAQV-EAQRVAAEQAEAQRLADE 129
+ Q +EQ A E E A+ + + Q E + +E E Q +
Sbjct: 1043 NSKQESKTVEKNEQDAT-ETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETK 1101

Query: 130 QAGQAEAQRIEAERLESARIEAEQARLAAEQAEQARLAAGQAAQVEEERLESARIEADRV 189
+ E + E ++E+ + + E ++ ++ + + + Q E R +
Sbjct: 1102 ETATVEKE--EKAKVETEKTQ-EVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEP 1158

Query: 190 AAEQAAQAAQAEAQRVEAERIEAERLEAERVAAERVVAEQARLAAEQAEAVRIEQERLEA 249
++ A + + + +E E+ V V E A E+
Sbjct: 1159 QSQTNTTADTEQPAKETSSNVEQPVTESTTVNTGNSVVENPE---NTTPATTQPTVNSES 1215

Query: 250 ERLESERVAAEQARLAAEQAEAARIEQERLEAERL 284
R R E A L
Sbjct: 1216 SNKPKNR-HRRSVRSVPHNVEPATTSSNDRSTVAL 1249



Score = 57.8 bits (139), Expect = 1e-10
Identities = 29/227 (12%), Positives = 57/227 (25%), Gaps = 12/227 (5%)

Query: 110 QVEAQRVAAEQAEAQRLADEQAGQAEAQRIEAERLESARI---------EAEQARLAAEQ 160
+VE + + + QA E +E AE
Sbjct: 984 EVEKRNQTVDTTNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTETVAEN 1043

Query: 161 AEQARLAAGQAAQVEEERLESARIEADRVAAEQAAQAAQAEAQRVEAERIEAERLEAERV 220
++Q + Q E R A + A E + +E E + E +
Sbjct: 1044 SKQESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETKET 1103

Query: 221 AAERVVAEQARLAAEQAEAVRIE-QERLEAERLESERVAAEQAR--LAAEQAEAARIEQE 277
A + + E ++ Q + E+ E+ + AE AR + + +
Sbjct: 1104 ATVEKEEKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEPQSQTN 1163

Query: 278 RLEAERLESERLEAERIAAEQAEAQRVEAERIAAEAAAQQAEEQQPE 324
++ + + QP
Sbjct: 1164 TTADTEQPAKETSSNVEQPVTESTTVNTGNSVVENPENTTPATTQPT 1210



Score = 56.6 bits (136), Expect = 3e-10
Identities = 49/321 (15%), Positives = 96/321 (29%), Gaps = 35/321 (10%)

Query: 60 EQAEAQRLADEQAAQVEAQRLADEQAAQVEAQRVAAEQAEAQRLAGEQAAQVEAQRVAAE 119
E + + D + + QA E A A
Sbjct: 984 EVEKRNQTVD--TTNITT--PNNIQADVPSVPSNNEEIARVDEA-------PVPPPAPAT 1032

Query: 120 QAEAQRLADEQAGQAEAQRIEAERLESARIEAEQARLAAEQAEQARLAAGQAAQVEEERL 179
+E E + Q E++ +E ++ A Q R A++A+ A Q +V +
Sbjct: 1033 PSETTETVAENSKQ-ESKTVEKNEQDATETTA-QNREVAKEAKSNVKANTQTNEVAQSGS 1090

Query: 180 ESARIEADRVAAEQAAQAAQAEAQ---RVEAERIEAERLEAERVAAERVVAE----QARL 232
E+ E ++ A E + +VE E+ + +V+ ++ +E QA
Sbjct: 1091 ET--KETQTTETKETA---TVEKEEKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEP 1145

Query: 233 AAEQAEAVRIEQERLEAERLESERVAAEQARLAAEQAEAARIEQERLEA-ERLESERLEA 291
A E V I++ + + A++ EQ + A
Sbjct: 1146 ARENDPTVNIKEPQSQTNTTADTEQPAKETSSNVEQPVTESTTVNTGNSVVENPENTTPA 1205

Query: 292 ERIAAEQAEAQRVEAERIAAEAAAQQAEEQQPEPQAKPVKEGLFARLKRGLKRTSESIGS 351
+E+ R + ++ EP + L + ++ S
Sbjct: 1206 TTQPTVNSESSNKPKNR---HRRSVRSVPHNVEPATTSSNDRSTVALCDLTSTNTNAVLS 1262

Query: 352 ------GFIGLFSGKKIDDDL 366
F+ L GK + +
Sbjct: 1263 DARAKAQFVALNVGKAVSQHI 1283



Score = 52.4 bits (125), Expect = 5e-09
Identities = 34/201 (16%), Positives = 67/201 (33%), Gaps = 16/201 (7%)

Query: 143 RLESARIEAEQARLAAEQAEQARLAAGQAAQVEEERLESAR----IEADRVAAEQAAQAA 198
L + +E + V E AR A +
Sbjct: 979 DLYNPEVEKRNQTVDTTNITTPNNIQADVPSVPSNNEEIARVDEAPVPPPAPATPSETTE 1038

Query: 199 Q-AEAQRVEAERIEAERLEA-ERVAAERVVAEQARL----AAEQAEAVRIEQERLEAERL 252
AE + E++ +E +A E A R VA++A+ + E + E E +
Sbjct: 1039 TVAENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTT 1098

Query: 253 ESERVAAEQARLAAEQAEAARIEQERLEAERLESERLEAERIAAEQAEAQRVEAERIAAE 312
E++ A + + E + ++ ++ ++ ++E + QAE R E
Sbjct: 1099 ETKE-TATVEKEEKAKVETEKTQEVPKVTSQVSPKQEQSETVQP-QAEPAR---ENDPTV 1153

Query: 313 AAAQ-QAEEQQPEPQAKPVKE 332
+ Q++ +P KE
Sbjct: 1154 NIKEPQSQTNTTADTEQPAKE 1174


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3988RTXTOXIND425e-06 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 42.1 bits (99), Expect = 5e-06
Identities = 31/167 (18%), Positives = 54/167 (32%), Gaps = 28/167 (16%)

Query: 400 LRKARLRLELLGVSSDTIKQLERTGKTIYRVPFYAEQDGFISKLTVR-HGMYVQPGDTLF 458
LR+ + LL +L + + A + +L V G V +TL
Sbjct: 304 LRQTTDNIGLL------TLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTTAETLM 357

Query: 459 EIV-DLSSVWVIADVFENEQSWLEQGRPVEVTSAAQGLFD------LESTIDYIYPELDP 511
IV + ++ V A V + ++ G+ + A F L + I +
Sbjct: 358 VIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEA---FPYTRYGYLVGKVKNINLDAIE 414

Query: 512 VSR---AMRVRIKLDNPDKL-------LKPGTLVDVKLFGGPKREVL 548
R V I ++ L G V ++ G R V+
Sbjct: 415 DQRLGLVFNVIISIEENCLSTGNKNIPLSSGMAVTAEIKTG-MRSVI 460



Score = 33.3 bits (76), Expect = 0.003
Identities = 19/83 (22%), Positives = 37/83 (44%), Gaps = 10/83 (12%)

Query: 345 VNGWIETLMVHNVGQRVKKGQLLYELYSP----ELINAQDDYMQAVDYLTQDKSRGQGLL 400
N ++ ++V G+ V+KG +L +L + + + Q +QA +++R Q L
Sbjct: 103 ENSIVKEIIVKE-GESVRKGDVLLKLTALGAEADTLKTQSSLLQA----RLEQTRYQILS 157

Query: 401 RKARL-RLELLGVSSDTIKQLER 422
R L +L L + + Q
Sbjct: 158 RSIELNKLPELKLPDEPYFQNVS 180


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3989ACRIFLAVINRP6820.0 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 682 bits (1761), Expect = 0.0
Identities = 217/1056 (20%), Positives = 425/1056 (40%), Gaps = 53/1056 (5%)

Query: 9 SIKQRAMVLVLTAVIALIGYQAMRMTPLDALPDLSDVQVIVKTSYPGQAPQLVEDQITYP 68
I++ VL ++ + G A+ P+ P ++ V V +YPG Q V+D +T
Sbjct: 5 FIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDTVTQV 64

Query: 69 LSTAMLAVPGAQTVRGFSM-FGDSYVYIIFEDGTDIYWARSRVLEYLSQTQGQLPDSV-T 126
+ M + + S G + + F+ GTD A+ +V L LP V
Sbjct: 65 IEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQEVQQ 124

Query: 127 PTLGPDASGVGWVFQYALVDRKGKHDLAQLRSLQDWFLKLELQSVEGVSEVATIGGMEQS 186
+ + S ++ V + +K L + GV +V G + +
Sbjct: 125 QGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGA-QYA 183

Query: 187 YQIIVDPHKLALYQIDLMTVKNALDNSNSSTGGSVIEMA------EAEYMITSSGYRQTL 240
+I +D L Y++ + V N L N + + I + +
Sbjct: 184 MRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRFKNP 243

Query: 241 ADFEEIPLGIVSESGTPVLMKDVAQLRTGPAARRGIAELNGEGEVVGGIVVMRYGENALA 300
+F ++ L V+ G+ V +KDVA++ G IA +NG+ G + + G NAL
Sbjct: 244 EEFGKVTL-RVNSDGSVVRLKDVARVELGGENYNVIARINGK-PAAGLGIKLATGANALD 301

Query: 301 TINNVKQKLKEIENGLPDGVELVITYDRSELILNSVDNLKHKVLEEMLVVAVICLIFLLH 360
T +K KL E++ P G++++ YD + + S+ + + E +++V ++ +FL +
Sbjct: 302 TAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQN 361

Query: 361 ARSTLVAIISLPISILISFIVMNMIGVNANIMSLGGIAIAIGAVVDAAIVMVENTHKHLE 420
R+TL+ I++P+ +L +F ++ G + N +++ G+ +AIG +VD AIV+VEN + +
Sbjct: 362 MRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVMM 421

Query: 421 HYREQHNGATPTGEAHWELVRKSSVEVGPALFFSLLIITLSFVPVFALEAQEGRLFHPLA 480
E KS ++ AL ++++ F+P+ G ++ +
Sbjct: 422 ----------EDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFS 471

Query: 481 YTKTFAMAASAILAITLIPVLMGYFVRGKIPDERK---------NPISRFLIAIYEPTLR 531
T AMA S ++A+ L P L ++ + + N + Y ++
Sbjct: 472 ITIVSAMALSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVG 531

Query: 532 LVLRFPKITILLAIVTLASAVYPMTKMGSEFMPELEEGDLLYMPTTLPSVSAGKAAEILQ 591
+L +L+ + +A V ++ S F+PE ++G L M + + ++L
Sbjct: 532 KILGSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLD 591

Query: 592 QTDRLIKT--VPEVKRVFGKVGRAMTATDPAPLTMLETTIMLNPRDTW-REGMTLEGIIA 648
Q V+ VF G + + L P + + + E +I
Sbjct: 592 QVTDYYLKNEKANVESVFTVNGF---SFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIH 648

Query: 649 ELQRTVKVPGMTNAWVQPIK-TRIDMLSTGVRTPVG-IKISGADIEELQRIGTEIEAVVS 706
+ ++ + + +V P I L T I +G + L + ++ + +
Sbjct: 649 RAKM--ELGKIRDGFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAA 706

Query: 707 KLPGT-ESAFAQRTSGGRYIDIEPDLKNAARYGMTLKDIQDVVQMAIGGMQVGQSIQGQE 765
+ P + S +E D + A G++L DI + A+GG V I
Sbjct: 707 QHPASLVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGR 766

Query: 766 RYPINIRYPRELRDSIEKLEDLPVLTKTGKYLPLGNLASISISDGAPMLASENGRLISWV 825
+ ++ + R E ++ L V + G+ +P + G+P L NG +
Sbjct: 767 VKKLYVQADAKFRMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEI 826

Query: 826 F-VDLKDISIGEYITSARAALDEQISLPPRYSYSFAGQYEYMQRVEAKMQLVVPLMLAVI 884
S G+ + + LP Y + G + + +V + V+
Sbjct: 827 QGEAAPGTSSGDAMALMENLASK---LPAGIGYDWTGMSYQERLSGNQAPALVAISFVVV 883

Query: 885 FMLLMMTFSSFIQASVIMLSLPFSLVGSAWLLYFLNFDFSVAVSVGMIALAGVAAEFGVV 944
F+ L + S+ +ML +P +VG N V VG++ G++A+ ++
Sbjct: 884 FLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAIL 943

Query: 945 MQVYLNNSIRDRKLAGLYNKRSDLSEALIHGAVMRIRPKAMTVATIFFGLLPIMWGSGTG 1004
+ + + + + EA + MR+RP MT G+LP+ +G G
Sbjct: 944 IVEFAKDLMEKEGK--------GVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAG 995

Query: 1005 NEVMQKIAAPMVGGMVTAPILSLFVIPAIYLLIYGR 1040
+ + ++GGMV+A +L++F +P +++I
Sbjct: 996 SGAQNAVGIGVMGGMVSATLLAIFFVPVFFVVIRRC 1031


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3992RTXTOXIND491e-08 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 49.4 bits (118), Expect = 1e-08
Identities = 56/339 (16%), Positives = 111/339 (32%), Gaps = 70/339 (20%)

Query: 75 GKVENIYVKPNQKVEAGQLIYDLDAEPYQIALNKALVAQETAKVN--------------- 119
V+ I VK + V G ++ L A + K + A++
Sbjct: 105 SIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNK 164

Query: 120 ---LSLSREDVKLALKQHEVAIADVSIT------KNQLNAASKDLAWKQKTLARFVEQNR 170
L L E + + EV I +NQ +L K+ + +
Sbjct: 165 LPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARIN 224

Query: 171 VVPDT-------------------ITKSQLDEQQTAVDLANAQVQTYSTQIEKAQMAEHT 211
+ I K + EQ+ A +++ Y +Q+E+ E
Sbjct: 225 RYENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQ---IESE 281

Query: 212 ALLNIEKSRLAVESRQSDLNSEH-----------ENVAQAQWNIDNTKIYAPTDGYVTNF 260
L E+ +L + ++++ + +A+ + + I AP V
Sbjct: 282 ILSAKEEYQLVTQLFKNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQL 341

Query: 261 -IMREGQYVGVA-PRMQMY-TNEKY-VLMRVNHQAIRNVKVGQLAEFASAVYPGK---VF 313
+ EG V A M + ++ V V ++ I + VGQ A +P
Sbjct: 342 KVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYL 401

Query: 314 SAEVEGI------VEATGESQGRLVALDDNVRQTTGQNL 346
+V+ I + G ++++++N T +N+
Sbjct: 402 VGKVKNINLDAIEDQRLGLVFNVIISIEENCLSTGNKNI 440


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3994HTHFIS300.012 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 30.2 bits (68), Expect = 0.012
Identities = 7/19 (36%), Positives = 15/19 (78%)

Query: 257 AALFGISRQQLQRRLQKLG 275
A L G++R L++++++LG
Sbjct: 456 ADLLGLNRNTLRKKIRELG 474


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4015ANTHRAXTOXNA320.010 Anthrax toxin LF subunit signature.
		>ANTHRAXTOXNA#Anthrax toxin LF subunit signature.

Length = 800

Score = 32.0 bits (72), Expect = 0.010
Identities = 31/93 (33%), Positives = 38/93 (40%), Gaps = 4/93 (4%)

Query: 373 TTIFPHAPQNQWDKSVRTLANLVKMHKVELIAIGNGTASRETDKLAADLISQVKAELPRL 432
T I PQ +WDK V T +L K V + I G R+ D L + K L RL
Sbjct: 502 TEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGI-ERKPDSTKGTLSNWQKQMLDRL 560

Query: 433 T---KIMVSEAGASVYSASELASEEFPNIDVSI 462
K G V +E +EEFP D I
Sbjct: 561 NEAVKYTGYTGGDVVNHGTEQDNEEFPEKDNEI 593


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4017HTHFIS987e-26 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 98.4 bits (245), Expect = 7e-26
Identities = 39/137 (28%), Positives = 72/137 (52%), Gaps = 3/137 (2%)

Query: 6 SKILVVDDDMRLRALLERYLMEQGYQVRSAANAEQMDRLLERENFHLLVLDLMLPGEDGL 65
+ ILV DDD +R +L + L GY VR +NA + R + + L+V D+++P E+
Sbjct: 4 ATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAF 63

Query: 66 SICRRLRQTGNPIPIVMLTAKGDEVDRIIGLELGADDYLPKPFNPRELLARIKAVM---R 122
+ R+++ +P+++++A+ + I E GA DYLPKPF+ EL+ I + +
Sbjct: 64 DLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPK 123

Query: 123 RQTPEVPGAPTQQEEEI 139
R+ ++ +
Sbjct: 124 RRPSKLEDDSQDGMPLV 140


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4018PF06580446e-07 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 44.1 bits (104), Expect = 6e-07
Identities = 28/187 (14%), Positives = 64/187 (34%), Gaps = 44/187 (23%)

Query: 272 IVNDIEDMDAIINQFISYIRQDQEGTRELEQINI-----LIQDVIQAESNREGD------ 320
I+ D ++ +R + Q+++ ++ +Q S + D
Sbjct: 186 ILEDPTKAREMLTSLSELMRYSLRYSNA-RQVSLADELTVVDSYLQLASIQFEDRLQFEN 244

Query: 321 -IESELVTCPIVPMQAIAVKRVISNLVENAYRYG------NGWVRINSQFNGKYVGFSVE 373
I ++ + PM ++ LVEN ++G G + + + V VE
Sbjct: 245 QINPAIMDVQVPPM-------LVQTLVENGIKHGIAQLPQGGKILLKGTKDNGTVTLEVE 297

Query: 374 DNGPGIDEEQIPKLFQPFTQGDTARGSVGSGLGLA-IIKRIVDRHQGKVILT-NRSEGGL 431
+ G + +G GL + +R+ + + + + +G +
Sbjct: 298 NTGSLALKNTKE----------------STGTGLQNVRERLQMLYGTEAQIKLSEKQGKV 341

Query: 432 HAQVWLP 438
+A V +P
Sbjct: 342 NAMVLIP 348


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4025HTHTETR483e-09 TetR bacterial regulatory protein HTH signature.
		>HTHTETR#TetR bacterial regulatory protein HTH signature.

Length = 215

Score = 48.5 bits (115), Expect = 3e-09
Identities = 16/58 (27%), Positives = 31/58 (53%)

Query: 3 SKTLEYILNVSEQLIYKDGVIGFKFCTVAKEAGISTTSLYKFFGNKEDILVALASKSF 60
+T ++IL+V+ +L + GV +AK AG++ ++Y F +K D+ + S
Sbjct: 10 QETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSE 67


57Spea_4072Spea_4077Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_40722301.832938NADH:flavin oxidoreductase
Spea_40732321.169763hypothetical protein
Spea_40744380.835080amidohydrolase
Spea_40753380.583171hypothetical protein
Spea_40762281.210740Asp/Glu racemase
Spea_40772241.248043peptidase M24
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4072PYOCINKILLER290.023 Pyocin S killer protein signature.
		>PYOCINKILLER#Pyocin S killer protein signature.

Length = 617

Score = 29.4 bits (65), Expect = 0.023
Identities = 22/73 (30%), Positives = 28/73 (38%), Gaps = 2/73 (2%)

Query: 105 GTKTTYNVGERVIFAPSAIAERGTQTMGKAMTKAEIDYIVK--AFAEASRRAQESGFDGV 162
G YNV S T T KA +A + A AEA R+A+E
Sbjct: 183 GLTAAYNVKLFTEAISSLQIRMNTLTAAKASIEAAAANKAREQAAAEAKRKAEEQARQQA 242

Query: 163 EIHAAHTYLINQF 175
I AA+TY +
Sbjct: 243 AIRAANTYAMPAN 255


58Spea_4125Spea_4134Y        NNGenomic Island
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_41254331.532878ribokinase-like domain-containing protein
Spea_41264381.025325coproporphyrinogen III oxidase
Spea_41276441.426313formate dehydrogenase subunit gamma
Spea_41286452.3020744Fe-4S ferredoxin
Spea_41296432.180001molybdopterin oxidoreductase
Spea_41304331.659354formate dehydrogenase region TAT target
Spea_41314352.034050formate dehydrogenase subunit gamma
Spea_41324332.2762524Fe-4S ferredoxin
Spea_41333312.433278molybdopterin oxidoreductase
Spea_41342231.892383formate dehydrogenase region TAT target
59Spea_4164Spea_4211Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_4164-2204.0747231-aminocyclopropane-1-carboxylate deaminase
Spea_4165-1194.419557Na+/H+ antiporter NhaC
Spea_4166-1195.011016putative endoribonuclease L-PSP
Spea_4167-1153.949611LysR family transcriptional regulator
Spea_4168-2131.755438histidine ammonia-lyase
Spea_4169-39-0.699911urocanate hydratase
Spea_4170-214-2.528283histidine utilization repressor
Spea_4171-115-2.672950imidazolonepropionase
Spea_4172019-4.512815hypothetical protein
Spea_4173014-3.191443ATPase AAA
Spea_4174016-1.483106hypothetical protein
Spea_4175-115-0.648758ABC transporter-like protein
Spea_4176015-0.527584hypothetical protein
Spea_4177118-0.577018hypothetical protein
Spea_4178018-0.276061lytic transglycosylase
Spea_4179218-0.859770hypothetical protein
Spea_4180119-0.7163132,3-diketo-5-methylthio-1-phosphopentane
Spea_4181218-0.437810hypothetical protein
Spea_41821190.453083hypothetical protein
Spea_41830200.942398thioesterase superfamily protein
Spea_41840201.227796hypothetical protein
Spea_4185-1182.748285thioesterase superfamily protein
Spea_4186-2183.127224AMP-dependent synthetase and ligase
Spea_4187-1234.166316hypothetical protein
Spea_4188-1234.426836ABC transporter-like protein
Spea_4189-1234.352925GntR family transcriptional regulator
Spea_41900244.232278TAP domain-containing protein
Spea_41910171.482397ABC transporter-like protein
Spea_41920161.059574ABC-2 type transporter
Spea_4193-1140.656056hypothetical protein
Spea_4194-2141.128607AraC family transcriptional regulator
Spea_4195-3140.942469hypothetical protein
Spea_4196-2131.599790methyl-accepting chemotaxis sensory transducer
Spea_4197-1202.695943molybdenum cofactor biosynthesis protein MogA
Spea_4198-1203.352973hypothetical protein
Spea_4199-1213.492826hypothetical protein
Spea_42000213.671144NLP/P60 protein
Spea_42010224.014359ABC-2 type transporter
Spea_42020223.865133ABC transporter-like protein
Spea_42030183.261023hypothetical protein
Spea_42040172.784764outer membrane protein
Spea_42050172.759505TolC family type I secretion outer membrane
Spea_42060182.545930HlyD family type I secretion membrane fusion
Spea_42070162.348482ABC transporter-like protein
Spea_42080131.744107autotransporter adhesin
Spea_42090140.094416LysR family transcriptional regulator
Spea_42102140.193977glyoxalase/bleomycin resistance
Spea_4211215-0.535057hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4171UREASE354e-04 Urea amidohydrolase (urease) protein signature.
		>UREASE#Urea amidohydrolase (urease) protein signature.

Length = 570

Score = 35.5 bits (82), Expect = 4e-04
Identities = 14/33 (42%), Positives = 20/33 (60%)

Query: 354 LAGMTRNAAKALGIEDQVGVIEVGMTADFCMWN 386
+A T N A A G+ ++G +EVG AD +WN
Sbjct: 406 IAKYTINPAIAHGLSHEIGSLEVGKRADLVLWN 438



Score = 32.4 bits (74), Expect = 0.004
Identities = 17/61 (27%), Positives = 31/61 (50%), Gaps = 6/61 (9%)

Query: 23 YGAITDAALAVQDGKIAWVGKRSD---LPEFDVF---ATPIYKGKGGWITPGLIDAHTHL 76
+ I A + ++DG+IA +GK + P + T + G+G +T G +D+H H
Sbjct: 80 HWGIVKADIGLKDGRIAAIGKAGNPDMQPGVTIIVGPGTEVIAGEGKIVTAGGMDSHIHF 139

Query: 77 V 77
+
Sbjct: 140 I 140


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4176RTXTOXIND290.027 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 29.4 bits (66), Expect = 0.027
Identities = 14/82 (17%), Positives = 30/82 (36%), Gaps = 5/82 (6%)

Query: 116 SELALLEEQANQQRVMAESAQELEDQRGKIRLAKVRLALADAELIAHKKLKDNQVISTL- 174
++ A+LE Q+ E+ EL + ++ + + A E +L N+++ L
Sbjct: 250 AKHAVLE----QENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLR 305

Query: 175 DLHKALVAWEQEDAMLQMELSR 196
+ E A +
Sbjct: 306 QTTDNIGLLTLELAKNEERQQA 327


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4196FLAGELLIN300.036 Flagellin signature.
		>FLAGELLIN#Flagellin signature.

Length = 507

Score = 29.6 bits (66), Expect = 0.036
Identities = 31/222 (13%), Positives = 65/222 (29%), Gaps = 12/222 (5%)

Query: 312 VATAMNEMTATVVEVAKNANDAADAAVQTDTQSQAGLTVVNNTVQTIEGLAVGIERASQV 371
+A + + ++NAND A T+ L +NN +Q + L+V +
Sbjct: 49 IANRFTSNIKGLTQASRNANDGISIAQTTE----GALNEINNNLQRVRELSVQATNGTNS 104

Query: 372 VKDLEDDSHQIGSILDVIKGIAEQT-----NLLALNAAIEAARAGEQGRGFAVVADEVRT 426
DL+ +I L+ I ++ QT +L+ + ++ G + ++
Sbjct: 105 DSDLKSIQDEIQQRLEEIDRVSNQTQFNGVKVLSQDNQMKIQVGANDGETITIDLQKIDV 164

Query: 427 LASRTQESTEEIQRMIEKLQGGAKLAADAMSDSRQYVDDSVNHARSAGEVLQSIAKAIAT 486
+ + + D+ Y + + T
Sbjct: 165 KSLGLDGFNVNGPKEATVGDLKSSFKNVTGYDT--YAVGANKYRVDVNSGAVVTDTTAPT 222

Query: 487 ITDMNTQIATAAEEQSTVSEEINTNIVNISNAAEETAAGTMS 528
+ D A + +T E NT +
Sbjct: 223 VPDKVYVNAANG-QLTTDDAENNTAVDLFKTTKSTAGTAEAK 263


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4201ABC2TRNSPORT452e-07 ABC-2 type transport system membrane protein signat...
		>ABC2TRNSPORT#ABC-2 type transport system membrane protein

signature.
Length = 262

Score = 44.5 bits (105), Expect = 2e-07
Identities = 51/195 (26%), Positives = 91/195 (46%), Gaps = 14/195 (7%)

Query: 194 GVILTMTMIMFT----SAAIVRERERGNLEMLITTPIRSIELMLGKIIPYMFIGILQ--- 246
G++ T M T AA R + E ++ T +R +++LG++ L
Sbjct: 72 GMVATSAMTAATFETIYAAFGRMEGQRTWEAMLYTQLRLGDIVLGEMAWAATKAALAGAG 131

Query: 247 -VIIILGLGYSVFNVPINGSLLQLAGATLLFIMASLTLGLVISTIAKSQLQSMQMTIFVL 305
++ LGY+ + SLL L +A +LG+V++ +A S + V+
Sbjct: 132 IGVVAAALGYTQWL-----SLLYALPVIALTGLAFASLGMVVTALAPSYDYFIFYQTLVI 186

Query: 306 LPSILLSGFMFPYEGMPIEAQYIAEALPATHFMRLIRGVVLRDVEIIDMTYDVTWLAIFT 365
P + LSG +FP + +PI Q A LP +H + LIR ++L ++D+ V L I+
Sbjct: 187 TPILFLSGAVFPVDQLPIVFQTAARFLPLSHSIDLIRPIML-GHPVVDVCQHVGALCIYI 245

Query: 366 VIGLIVASMRFKKNL 380
VI +++ ++ L
Sbjct: 246 VIPFFLSTALLRRRL 260


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4203RTXTOXIND491e-08 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 49.1 bits (117), Expect = 1e-08
Identities = 28/163 (17%), Positives = 58/163 (35%), Gaps = 7/163 (4%)

Query: 42 SNEVVVALPVAQGSMVTKGTVLVQLDDTQQRAQVAKALADVAQSTANYEKLLKGARE-EE 100
N +V + V +G V KG VL++L A K + + Q+ + +R E
Sbjct: 103 ENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIEL 162

Query: 101 IAAARAKVSGAKATVQESEANYRRIASMAKDNLAS----KADLDRALASRDADTASLESA 156
K+ SE R+ S+ K+ ++ K + L + A+ ++ +
Sbjct: 163 NKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLAR 222

Query: 157 RENLRELVSGSREE--DIRFALANLQASEAVLLGEQKRLDDLT 197
L + D L ++ +L ++ + +
Sbjct: 223 INRYENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAV 265


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4204OMPADOMAIN509e-10 OMPA domain signature.
		>OMPADOMAIN#OMPA domain signature.

Length = 346

Score = 50.3 bits (120), Expect = 9e-10
Identities = 26/98 (26%), Positives = 44/98 (44%), Gaps = 5/98 (5%)

Query: 66 TSTVSVKEDFRVIMFGFDKDTLAPEQADKWRGIIAGLVQKQSP--SLYLVGDTSVEGSED 123
T ++K D ++F F+K TL PE + + L S+ ++G T GS+
Sbjct: 212 TKHFTLKSD---VLFNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDA 268

Query: 124 YNHALAKRRVDYITQLAVDQGFPASGIKEEVYFKQNHI 161
YN L++RR + + +G PA I + N +
Sbjct: 269 YNQGLSERRAQSVVDYLISKGIPADKISARGMGESNPV 306


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4206RTXTOXIND2531e-81 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 253 bits (648), Expect = 1e-81
Identities = 95/428 (22%), Positives = 191/428 (44%), Gaps = 8/428 (1%)

Query: 13 AKRANQLIFLVAALIVVTLVWASFAKLEEVVVGEGMVVPTLAVQQIESLDGGILKQVLVR 72
++R + + + +V+ + + ++E V G + + ++I+ ++ I+K+++V+
Sbjct: 54 SRRPRLVAYFIMGFLVIAFILSVLGQVEIVATANGKLTHSGRSKEIKPIENSIVKEIIVK 113

Query: 73 EGQSVSAGEPLLLLDELRFASAYDEANIQAAALKRQKARLDAEISSVVIDDAASYWRDKV 132
EG+SV G+ LL L L + + + ++ R S+ + +
Sbjct: 114 EGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSI-ELNKLPELKLPD 172

Query: 133 LIKPKAISALDVSVSTRSKAIYRSRLSQLSSQLEQSAQVIEQKVQAIEEGLITTQAQLSG 192
+ +S +V R ++ + + S +Q Q +++K L +
Sbjct: 173 EPYFQNVSEEEVL---RLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENL 229

Query: 193 LQLVKQEIVMTRAAVREGAVAELELLKLERDEIRLKGELSASKANGRQLRAAQNQAEAEY 252
++ K + + + + A+A+ +L+ E + EL K+ Q+ + A+ EY
Sbjct: 230 SRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEY 289

Query: 253 LTVALDFLSRAEAERNEVINELNALTESIKTLADRLARTQIVSPINGNVTNILVRSIGAV 312
V F + + + + + LT + +R + I +P++ V + V + G V
Sbjct: 290 QLVTQLFKNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGV 349

Query: 313 VEPGESIMGIVPQDGALIIETRIAPKDIAFVHTGLQATVKFTAYDFVIYGGLKGEVIYVS 372
V E++M IVP+D L + + KDI F++ G A +K A+ + YG L G+V ++
Sbjct: 350 VTTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNIN 409

Query: 373 PDAQQLDDGTTYFEAHIKTEENVL----NGWPIISGMQASTDILTGEKTVLNYWLKPLLR 428
DA + F I EEN L P+ SGM + +I TG ++V++Y L PL
Sbjct: 410 LDAIEDQRLGLVFNVIISIEENCLSTGNKNIPLSSGMAVTAEIKTGMRSVISYLLSPLEE 469

Query: 429 AKANALRE 436
+ +LRE
Sbjct: 470 SVTESLRE 477


60Spea_4231Spea_4242Y        Y        NPathogenicity Island (biased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_42313200.584857phosphate ABC transporter ATP-binding protein
Spea_42323200.722319hypothetical protein
Spea_42333210.700884guanosine 5'-monophosphate oxidoreductase
Spea_42342200.620922glucosamine--fructose-6-phosphate
Spea_42354240.387583DeoR family transcriptional regulator
Spea_42363250.205183TonB-dependent siderophore receptor
Spea_42373310.835702UDP-N-acetylglucosamine pyrophosphorylase
Spea_42385360.499373DsrE family protein
Spea_42395350.543756F0F1 ATP synthase subunit epsilon
Spea_42404360.069925F0F1 ATP synthase subunit beta
Spea_4241330-0.975375F0F1 ATP synthase subunit gamma
Spea_4242228-1.313328F0F1 ATP synthase subunit alpha
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4235FRAGILYSIN280.032 Fragilysin metallopeptidase (M10C) enterotoxin signat...
		>FRAGILYSIN#Fragilysin metallopeptidase (M10C) enterotoxin

signature.
Length = 405

Score = 28.5 bits (63), Expect = 0.032
Identities = 24/96 (25%), Positives = 36/96 (37%), Gaps = 8/96 (8%)

Query: 63 LLLRRYGGAVAVPDEVMQQFSAKIAPNKLSIARAAAELIKDHNRIIIDSGSTTSGLIGEL 122
+ LR G + P+EV Q A N + + H + S SG
Sbjct: 231 ICLRENGSTI-YPNEVSAQMQD--AANSVYAVHGLKRYVNFHFVLYTTEYSCPSG----- 282

Query: 123 NSKRGLLVMTNSLALANAIHDLENEPTLLMTGGTWD 158
++K GL T SL +++ L+ GTWD
Sbjct: 283 DAKEGLEGFTASLKSNPKAEGYDDQIYFLIRWGTWD 318


61Spea_0059Spea_0092N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_00593160.612358flagellar hook-length control protein
Spea_00603170.165559hypothetical protein
Spea_00611150.186430flagellar protein FliS
Spea_00621140.248599flagellar hook-associated 2 domain-containing
Spea_0063-1151.080247flagellin domain-containing protein
Spea_0064-1161.519415hypothetical protein
Spea_0065-1172.258060flagellar hook-associated protein 3
Spea_0066-1163.198643flagellar hook-associated protein FlgK
Spea_00670194.061465peptidoglycan hydrolase
Spea_00681193.946305flagellar basal body P-ring protein
Spea_00690203.792177flagellar basal body L-ring protein
Spea_0070-1183.705652flagellar basal-body rod protein FlgG
Spea_0071-1163.279088flagellar basal-body rod protein FlgF
Spea_00720152.115665flagellar hook protein FlgE
Spea_0073-1141.494571flagellar hook capping protein
Spea_00741171.239886flagellar basal-body rod protein FlgC
Spea_00750182.567186flagellar basal body rod protein FlgB
Spea_00760162.976742SAF domain-containing protein
Spea_00770153.228835hypothetical protein
Spea_0078-1143.262920hypothetical protein
Spea_0079-2153.276855hypothetical protein
Spea_0080-2153.369808FliI/YscN family ATPase
Spea_00810132.542393flagellar assembly protein H
Spea_0082-1132.025727flagellar motor switch protein G
Spea_0083-1141.655936flagellar MS-ring protein
Spea_00840151.003369flagellar hook-basal body complex subunit FliE
Spea_00850151.031107sigma-54 dependent trancsriptional regulator
Spea_00861170.466893OmpA/MotB domain-containing protein
Spea_00871170.439387hypothetical protein
Spea_00880211.956149flagellar motor switch protein FliN
Spea_00890212.498871flagellar biosynthesis protein FliP
Spea_0090-1203.260669flagellar biosynthetic protein FliQ
Spea_0091-2192.625036flagellar biosynthetic protein FliR
Spea_0092-1192.533014flagellar biosynthetic protein FlhB
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0059FLGHOOKFLIK392e-05 Flagellar hook-length control protein signature.
		>FLGHOOKFLIK#Flagellar hook-length control protein signature.

Length = 375

Score = 39.4 bits (91), Expect = 2e-05
Identities = 29/100 (29%), Positives = 49/100 (49%)

Query: 236 ASSTRSQTAVAQWGPVAVSQTAPLLQQAHEMLSPLREQLKFQIDQQIKQAEIRLDPPELG 295
A+S Q P + +HE L + + Q + AE+RL P +LG
Sbjct: 210 AASPLITPHQTQPLPTVAAPVLSAPLGSHEWQQSLSQHISLFTRQGQQSAELRLHPQDLG 269

Query: 296 KVELNVRLDGDRLHIQMHAANSSVRDALLMGLDRLRAELA 335
+V++++++D ++ IQM + + VR AL L LR +LA
Sbjct: 270 EVQISLKVDDNQAQIQMVSPHQHVRAALEAALPVLRTQLA 309


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0063FLAGELLIN1072e-28 Flagellin signature.
		>FLAGELLIN#Flagellin signature.

Length = 507

Score = 107 bits (267), Expect = 2e-28
Identities = 76/269 (28%), Positives = 123/269 (45%), Gaps = 8/269 (2%)

Query: 4 VMTNNASNIAQNSVNRNNDLLSNAMERLSTGLRINSAADDAAGLQIASRMEANVTGMETA 63
+ TN+ S + QN++N++ LS+A+ERLS+GLRINSA DDAAG IA+R +N+ G+ A
Sbjct: 4 INTNSLSLLTQNNLNKSQSSLSSAIERLSSGLRINSAKDDAAGQAIANRFTSNIKGLTQA 63

Query: 64 NRNVSDATSMLQTADGALDELATIANRQKELATQAANGVNSTADRAALNDEFTALTAEMT 123
+RN +D S+ QT +GAL+E+ R +EL+ QA NG NS +D ++ DE E+
Sbjct: 64 SRNANDGISIAQTTEGALNEINNNLQRVRELSVQATNGTNSDSDLKSIQDEIQQRLEEID 123

Query: 124 RIMEKTTYAGNDLFGAISGNVSFQIGAGSGETLTV------SGASGITGIRSGIATLSGV 177
R+ +T + G + + Q+GA GET+T+ + G+ G + V
Sbjct: 124 RVSNQTQFNGVKVLSQ-DNQMKIQVGANDGETITIDLQKIDVKSLGLDGFNVNGPKEATV 182

Query: 178 KASTL-GAQIGEIDDFIDAVGSMRSDLGANINRLGHTASNLTNVTENTKAAAGRIMDADF 236
+ D + R D+ + TA + + A D
Sbjct: 183 GDLKSSFKNVTGYDTYAVGANKYRVDVNSGAVVTDTTAPTVPDKVYVNAANGQLTTDDAE 242

Query: 237 ASETAAMSKNQLLVQAGTNILSSSNQNTG 265
+ + K + + G
Sbjct: 243 NNTAVDLFKTTKSTAGTAEAKAIAGAIKG 271



Score = 64.7 bits (157), Expect = 6e-14
Identities = 43/204 (21%), Positives = 74/204 (36%)

Query: 68 SDATSMLQTADGALDELATIANRQKELATQAANGVNSTADRAALNDEFTALTAEMTRIME 127
+ + T A + + + V + + +
Sbjct: 303 INGEKVTLTVADITAGAANVDAATLQSSKNVYTSVVNGQFTFDDKTKNESAKLSDLEANN 362

Query: 128 KTTYAGNDLFGAISGNVSFQIGAGSGETLTVSGASGITGIRSGIATLSGVKASTLGAQIG 187
+ + T+ +G+ + I + + +
Sbjct: 363 AVKGESKITVNGAEYTANAAGDKVTLAGKTMFIDKTASGVSTLINEDAAAAKKSTANPLA 422

Query: 188 EIDDFIDAVGSMRSDLGANINRLGHTASNLTNVTENTKAAAGRIMDADFASETAAMSKNQ 247
ID + V ++RS LGA NR +NL N N +A RI DAD+A+E + MSK Q
Sbjct: 423 SIDSALSKVDAVRSSLGAIQNRFDSAITNLGNTVTNLNSARSRIEDADYATEVSNMSKAQ 482

Query: 248 LLVQAGTNILSSSNQNTGLVMGLL 271
+L QAGT++L+ +NQ V+ LL
Sbjct: 483 ILQQAGTSVLAQANQVPQNVLSLL 506


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0064FbpA_PF05833371e-04 Fibronectin-binding protein
		>FbpA_PF05833#Fibronectin-binding protein

Length = 577

Score = 36.8 bits (85), Expect = 1e-04
Identities = 32/270 (11%), Positives = 95/270 (35%), Gaps = 17/270 (6%)

Query: 40 PTHRLESYNKWAKVTQGQHRISAAQVAEQGLQQVQQ---------LLKQLQSQVKQSLAS 90
+ +L ++ + + + ++ Q+ + ++ + +L++ S
Sbjct: 167 KSPKLNPFDFSYDMIENFTKENSLQLNDNIFSKIFTGVSKTLSSEICFRLKNNSIDLSLS 226

Query: 91 SASEQSMLEQTARSKLIQNKLSQLAISYDNKPLIDHQLNLISAKRPAAQHSFSLKSVDLT 150
+ E + + ++ NK + +N + + LNL+S + S +
Sbjct: 227 NLKEIVEVCKDLFKEIQSNKFEFNCYTKNNSFVGFYCLNLMSKEDYKKIQYDSSSKLLEN 286

Query: 151 ASKQRDERLII-QVGNQSTSLVLPANKQPQQLLTKINDSLKALEIKANHSKEGKLIFTSP 209
+D+ + + +V+ + + +N++LK E K G+L+ +
Sbjct: 287 FYYAKDKSDRLKSKSSDLQKIVMNNINRCTKKDKILNNTLKKCEDKDIFKLYGELLTAN- 345

Query: 210 KSQWQQIQTGILMTGQGQRLPAGEPRTIKVNEELSWQDPREWRFGSNAELKQAIAKIAKS 269
++ + I + + I ++E + + + +LK++ +
Sbjct: 346 IYALKKGLSHIELANYYS--ENYDTVKITLDENKTPSQNVQSYYKKYNKLKKSEEAANEQ 403

Query: 270 LHKVEQQLQELSDSKQKILQQLQQLSLKKD 299
L + E++L L +L + +
Sbjct: 404 LLQNEEELNYL----YSVLTNINNADNYDE 429


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0065FLAGELLIN492e-08 Flagellin signature.
		>FLAGELLIN#Flagellin signature.

Length = 507

Score = 48.5 bits (115), Expect = 2e-08
Identities = 33/201 (16%), Positives = 66/201 (32%), Gaps = 5/201 (2%)

Query: 1 MRVSMHNLYANNLQSLQNSTVDIARLNEMMATGSSILRPSDDPIGAVKVMGNERDMAATE 60
++ ++L +L S ++ E +++G I DD G ++
Sbjct: 2 QVINTNSLSLLTQNNLNKSQSSLSSAIERLSSGLRINSAKDDAAGQAIANRFTSNIKGLT 61

Query: 61 QYLKNTESLSSSFGRAETYMSSMVELQNRMREITVSASNGSLSAEDRTAYAAELEELLES 120
Q +N S E ++ + R+RE++V A+NG+ S D + E+++ LE
Sbjct: 62 QASRNANDGISIAQTTEGALNEINNNLQRVRELSVQATNGTNSDSDLKSIQDEIQQRLEE 121

Query: 121 FSDVLNAKDEGGNYLFSGNETDTPPIGKDAAGNYVYQGDTSHREVQTSSSSWMTANSTAA 180
V N G + S + +G + S + +
Sbjct: 122 IDRVSNQTQFNGVKVLSQDNQMKIQVGANDGETITIDLQKI-----DVKSLGLDGFNVNG 176

Query: 181 DFIFSNGSADILNQTKDFIDA 201
+ G + D
Sbjct: 177 PKEATVGDLKSSFKNVTGYDT 197


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0066FLGHOOKAP11672e-48 Flagellar hook-associated protein signature.
		>FLGHOOKAP1#Flagellar hook-associated protein signature.

Length = 546

Score = 167 bits (425), Expect = 2e-48
Identities = 95/320 (29%), Positives = 158/320 (49%), Gaps = 8/320 (2%)

Query: 2 SMLNIGMSGLNASMAALTATSNNVSNAMVPGYSRQQVVMSSVGNGTYGS---GSGVMVDG 58
S++N MSGLNA+ AAL SNN+S+ V GY+RQ +M+ + G+GV V G
Sbjct: 2 SLINNAMSGLNAAQAALNTASNNISSYNVAGYTRQTTIMAQANSTLGAGGWVGNGVYVSG 61

Query: 59 VRRISDQYQVTQQWNATSNLGFAETQASYFGQVEQIFGSEGNSISAGLDLLFASLNSAME 118
V+R D + Q A + + +++ + + +S++ + F SL + +
Sbjct: 62 VQREYDAFITNQLRAAQTQSSGLTARYEQMSKIDNMLSTSTSSLATQMQDFFTSLQTLVS 121

Query: 119 QPNEIALRQGVLNEAKALTQRFNSISEGVHTQVNQIEGQIGASAKEINAQLETISSFNEQ 178
+ A RQ ++ +++ L +F + + + Q Q+ IGAS +IN + I+S N+Q
Sbjct: 122 NAEDPAARQALIGKSEGLVNQFKTTDQYLRDQDKQVNIAIGASVDQINNYAKQIASLNDQ 181

Query: 179 IQAS--NASGNVPLSLLDARDAAIDDLSKIIDVNIVHDANNMVNISLVQGQPLLSGTTAS 236
I +G P +LLD RD + +L++I+ V + NI++ G L+ G+TA
Sbjct: 182 ISRLTGVGAGASPNNLLDQRDQLVSELNQIVGVEVSVQDGGTYNITMANGYSLVQGSTAR 241

Query: 237 KIQV---SPDPSNPLFSQLSVQFGQSSFPLDESAGGSLGALLDYRDNSLVESIAFNNELA 293
++ S DPS + + G P GSLG +L +R L ++ +LA
Sbjct: 242 QLAAVPSSADPSRTTVAYVDGTAGNIEIPEKLLNTGSLGGILTFRSQDLDQTRNTLGQLA 301

Query: 294 QTMADEFNTILKAGTDLNGN 313
A+ FNT KAG D NG+
Sbjct: 302 LAFAEAFNTQHKAGFDANGD 321



Score = 69.2 bits (169), Expect = 9e-15
Identities = 39/110 (35%), Positives = 63/110 (57%), Gaps = 3/110 (2%)

Query: 346 QDGTPGDNSNLKALVELADKSFTFDSMGIDATMGDAFASKIGELGSASRQAKMAKETAEK 405
+D DN N +AL++L S ++G + DA+AS + ++G+ + K + T
Sbjct: 438 EDAGDSDNRNGQALLDLQSNS---KTVGGAKSFNDAYASLVSDIGNKTATLKTSSATQGN 494

Query: 406 VQIEAQSQWASTSGVNMDEEGVNLIIYQQSYQANAKVISTADQLFQTILN 455
V + +Q S SGVN+DEE NL +QQ Y ANA+V+ TA+ +F ++N
Sbjct: 495 VVTQLSNQQQSISGVNLDEEYGNLQRFQQYYLANAQVLQTANAIFDALIN 544


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0067FLGFLGJ491e-09 Flagellar protein FlgJ signature.
		>FLGFLGJ#Flagellar protein FlgJ signature.

Length = 313

Score = 48.6 bits (115), Expect = 1e-09
Identities = 29/124 (23%), Positives = 56/124 (45%), Gaps = 16/124 (12%)

Query: 26 GALKLVSQQFEAQFLQTVLKQMRSASDVMADEDSPLSSQNDGMYRDWHDAELAGRLSQMQ 85
++ V++Q E F+Q +LK MR A +D SS++ +Y +D ++A +++ +
Sbjct: 31 ANIRPVARQVEGMFVQMMLKSMRDALP----KDGLFSSEHTRLYTSMYDQQIAQQMTAGK 86

Query: 86 STGLASVMTKQLSSA------------LKSSPETVASNQHETVNVANPNTRAMQPALIVP 133
GLA +M KQ++ +K ETV Q++ ++ +P
Sbjct: 87 GLGLAEMMVKQMTPEQPLPEESTPAAPMKFPLETVVRYQNQALSQLVQKAVPRNYDDSLP 146

Query: 134 FIAK 137
+K
Sbjct: 147 GDSK 150


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0068FLGPRINGFLGI343e-119 Flagellar P-ring protein signature.
		>FLGPRINGFLGI#Flagellar P-ring protein signature.

Length = 373

Score = 343 bits (882), Expect = e-119
Identities = 151/381 (39%), Positives = 219/381 (57%), Gaps = 15/381 (3%)

Query: 1 MKKIALFITSMLLALLPLL-PVQAEIQNRYLMDIVDVQGIRDNQLVGYGLVVGLDGTGDK 59
M+ + + +++ + LP L A+ + DI +Q RDNQL+GYGLVVGL GTGD
Sbjct: 1 MRVLRIIAAALVFSALPFLSTPPAQADTSRIKDIASLQAGRDNQLIGYGLVVGLQGTGDS 60

Query: 60 -NQVKFTSQSVVNMLKQFGVQIDDKTDPKLKNVAAVAVSATVPPLASPGQTLDITVSSLG 118
FT QS+ ML+ G+ KN+AAV V+A +PP ASPG +D+TVSSLG
Sbjct: 61 LRSSPFTEQSMRAMLQNLGITTQG-GQSNAKNIAAVMVTANLPPFASPGSRVDVTVSSLG 119

Query: 119 DAKSLRGGTLLMTPLRAVDGEIYAVAQGNLVVGGVSAQGRNGSSITVNIPTVGNIPNGAL 178
DA SLRGG L+MT L DG+IYAVAQG L+V G SAQG + +++T + T +PNGA+
Sbjct: 120 DATSLRGGNLIMTSLSGADGQIYAVAQGALIVNGFSAQG-DAATLTQGVTTSARVPNGAI 178

Query: 179 LEAAMKSNFNETEHIVLNLKQPSFKTARNIERAVNEL----FGPSVAEADSNAKVMVRAP 234
+E + S F ++ ++VL L+ P F TA + VN +G +AE + ++ V+ P
Sbjct: 179 IERELPSKFKDSVNLVLQLRNPDFSTAVRVADVVNAFARARYGDPIAEPRDSQEIAVQKP 238

Query: 235 SSNRERVTFMSMLEELQIEQGRKSPRVVFNSRTGTVVMGGDVVVRKAAVSHGNLTVSIVE 294
+ M+ +E L +E +VV N RTGT+V+G DV + + AVS+G LTV + E
Sbjct: 239 -RVADLTRLMAEIENLTVETDTP-AKVVINERTGTIVIGADVRISRVAVSYGTLTVQVTE 296

Query: 295 QQNVSQPNGAFLGQAQGETVVTNDSTVDIEQGNGHMFVWEEGVALDDIVRAVNSLGASPM 354
V QP F G+T V + + Q + + EG L +V +NS+G
Sbjct: 297 SPQVIQPA-PFSR---GQTAVQPQTDIMAMQEGSKVAI-VEGPDLRTLVAGLNSIGLKAD 351

Query: 355 DLMSILQALDEAGALEAELVV 375
+++ILQ + AGAL+AELV+
Sbjct: 352 GIIAILQGIKSAGALQAELVL 372


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0069FLGLRINGFLGH1445e-45 Flagellar L-ring protein signature.
		>FLGLRINGFLGH#Flagellar L-ring protein signature.

Length = 232

Score = 144 bits (364), Expect = 5e-45
Identities = 72/223 (32%), Positives = 112/223 (50%), Gaps = 15/223 (6%)

Query: 12 LVLLLSGCISHIPELDTKPGKPEWAPPEIDYSLPDAKDGSVYRPGFMLT-----LFKDKR 66
LVL L+GC + IP + P + +GS+++ + LF+D+R
Sbjct: 15 LVLSLTGC-AWIP---STPLVQGATSAQPVPGPTPVANGSIFQSAQPINYGYQPLFEDRR 70

Query: 67 AFREGDILTVALDEKTYSSKSADTKTNK--NTGLSLDGQGTTGNNSIAGSG---EANLGS 121
GD LT+ L E +SKS+ ++ T D + EA+ G+
Sbjct: 71 PRNIGDTLTIVLQENVSASKSSSANASRDGKTNFGFDTVPRYLQGLFGNARADVEASGGN 130

Query: 122 SFSGTGSSTQQNQLSGSITVTVAKVLPNGALLIRGEKWLRLNQGDEYLRLLGLIRTDDIG 181
+F+G G + N SG++TVTV +VL NG L + GEK + +NQG E++R G++ I
Sbjct: 131 TFNGKGGANASNTFSGTLTVTVDQVLVNGNLHVVGEKQIAINQGTEFIRFSGVVNPRTIS 190

Query: 182 NDNTISSQRIADARIIYGGQGAITDSNRMGWASRYFNSPWFPL 224
NT+ S ++ADARI Y G G I ++ MGW R+F + P+
Sbjct: 191 GSNTVPSTQVADARIEYVGNGYINEAQNMGWLQRFFLN-LSPM 232


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0070FLGHOOKAP1412e-06 Flagellar hook-associated protein signature.
		>FLGHOOKAP1#Flagellar hook-associated protein signature.

Length = 546

Score = 41.5 bits (97), Expect = 2e-06
Identities = 11/47 (23%), Positives = 21/47 (44%)

Query: 213 QVRQGALEGANVNVVEEMVEMISTQRAYEMNAKVVSASDDMLKFLNQ 259
Q+ + VN+ EE + Q+ Y NA+V+ ++ + L
Sbjct: 498 QLSNQQQSISGVNLDEEYGNLQRFQQYYLANAQVLQTANAIFDALIN 544



Score = 40.7 bits (95), Expect = 4e-06
Identities = 22/89 (24%), Positives = 36/89 (40%), Gaps = 17/89 (19%)

Query: 3 SALWVSKTGLTAQDTKMTTIANNLANVNTTGFKRDRVAFNDLFYQVQRQPGGQVDEQNQL 62
S + + +GL A + T +NN+++ N G+ R + L
Sbjct: 2 SLINNAMSGLNAAQAALNTASNNISSYNVAGYTRQTTI--------------MAQANSTL 47

Query: 63 PAGLQLGTGTRVAGTQKVFTPGDMLTTNQ 91
AG +G G V+G Q+ + D TNQ
Sbjct: 48 GAGGWVGNGVYVSGVQREY---DAFITNQ 73


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0072FLGHOOKAP1340.001 Flagellar hook-associated protein signature.
		>FLGHOOKAP1#Flagellar hook-associated protein signature.

Length = 546

Score = 33.8 bits (77), Expect = 0.001
Identities = 15/41 (36%), Positives = 22/41 (53%)

Query: 360 LEGSNVDQTAEMVNLMTAQRNYQSNAKVLDTNSTMQQALLN 400
S V+ E NL Q+ Y +NA+VL T + + AL+N
Sbjct: 504 QSISGVNLDEEYGNLQRFQQYYLANAQVLQTANAIFDALIN 544



Score = 33.0 bits (75), Expect = 0.002
Identities = 21/57 (36%), Positives = 27/57 (47%), Gaps = 5/57 (8%)

Query: 2 SFNIALSGLQATTQDLNTISNNIANSSTVGFRSGR----SEFSAIYNGGQAG-GVNV 53
N A+SGL A LNT SNNI++ + G+ S + GG G GV V
Sbjct: 3 LINNAMSGLNAAQAALNTASNNISSYNVAGYTRQTTIMAQANSTLGAGGWVGNGVYV 59


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0074FLGHOOKAP1334e-04 Flagellar hook-associated protein signature.
		>FLGHOOKAP1#Flagellar hook-associated protein signature.

Length = 546

Score = 32.6 bits (74), Expect = 4e-04
Identities = 8/39 (20%), Positives = 19/39 (48%)

Query: 98 SNVNTVEEMADMMAASRSFETSVEVMNRARSMQQGLLQL 136
S VN EE ++ + + + +V+ A ++ L+ +
Sbjct: 507 SGVNLDEEYGNLQRFQQYYLANAQVLQTANAIFDALINI 545



Score = 26.5 bits (58), Expect = 0.048
Identities = 14/59 (23%), Positives = 25/59 (42%), Gaps = 4/59 (6%)

Query: 9 IAGAGMNAQTIRLNTVASNLANAGAAAESPDQAFRALKPVFSTIYKQTQEGELAGAHVE 67
A +G+NA LNT ++N+++ A + + ST+ G G +V
Sbjct: 6 NAMSGLNAAQAALNTASNNISSYNVAGYTRQTTI--MAQANSTLGAGGWVGN--GVYVS 60


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_00772FE2SRDCTASE260.024 Ferric iron reductase signature.
		>2FE2SRDCTASE#Ferric iron reductase signature.

Length = 262

Score = 25.8 bits (56), Expect = 0.024
Identities = 11/37 (29%), Positives = 18/37 (48%)

Query: 39 AEVSDDCKLIAHNQPQLEQLADVDLDKVAQIRQSLID 75
A + +D H QPQ LA +A+ R+ L++
Sbjct: 6 APLYEDVIWRTHLQPQDPTLAQAVRATIAKHREHLLE 42


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0081FLGFLIH621e-13 Flagellar assembly protein FliH signature.
		>FLGFLIH#Flagellar assembly protein FliH signature.

Length = 228

Score = 61.7 bits (149), Expect = 1e-13
Identities = 45/200 (22%), Positives = 91/200 (45%), Gaps = 8/200 (4%)

Query: 24 FSPLIAPETDAEQSEMSWQDFQQAFDKGYDDGVQKGHQAGFDAGVEEGRQSGHAAGFNQG 83
F P++ PE E ++ + + ++ + H+ G+ AG+ EGRQ GH G+ +G
Sbjct: 22 FVPIVEPE------ETIIEEAEPSLEQQLAQLQMQAHEQGYQAGIAEGRQQGHKQGYQEG 75

Query: 84 RIEGQQKGKDNIDDQLNSIIAPLGALKSLLEEGHSQQIAQQQTLILDLVRRVSLQVIRCE 143
+G ++G Q I A + L S + + + ++ + + QVI
Sbjct: 76 LAQGLEQGLAEAKSQQAPIHARMQQLVSEFQTTLDALDSVIASRLMQMALEAARQVIGQT 135

Query: 144 LTLQPQQILNLVEETLSALPDDPTEVKIHLEPSAVDKLKEL--AADKIKHWTLVADASIS 201
T+ ++ +++ L P + ++ + P + ++ ++ A + W L D ++
Sbjct: 136 PTVDNSALIKQIQQLLQQEPLFSGKPQLRVHPDDLQRVDDMLGATLSLHGWRLRGDPTLH 195

Query: 202 AGGCRIVSATSDADASVETR 221
GGC++ + D DASV TR
Sbjct: 196 PGGCKVSADEGDLDASVATR 215


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0082FLGMOTORFLIG1746e-54 Flagellar motor switch protein FliG signature.
		>FLGMOTORFLIG#Flagellar motor switch protein FliG signature.

Length = 344

Score = 174 bits (442), Expect = 6e-54
Identities = 81/334 (24%), Positives = 168/334 (50%), Gaps = 4/334 (1%)

Query: 7 GIKMDNL---DQAAMLLLSMGEKGAAQVMAHLDRNDVQHLSHKMARLSSITQQEADAVLG 63
+ + L +AA+LL+S+G + +++V +L + +++ L+ ++A+L +IT + D VL
Sbjct: 9 ILDVSALTGKQKAAILLVSIGSEISSKVFKYLSQEEIESLTFEIAKLETITSELKDNVLL 68

Query: 64 RFFKRYQEQSGIARASRSYLQKTLDLALGDRVAKGLIDGIYGDEIKILVKRLEWVDPQLL 123
F + Q I + Y ++ L+ +LG + A +I+ + + + DP +
Sbjct: 69 EFKELMMAQEFIQKGGIDYARELLEKSLGTQKAVDIINNLGSALQSRPFEFVRRADPANI 128

Query: 124 AREIANEHCQLQAVLLGLLPPENAALVLEGLPASGQDEVLVRIAQLGDLDREVVDELRQL 183
I EH Q A++L L P+ A+ +L LP Q V RIA + EVV E+ ++
Sbjct: 129 LNFIQQEHPQTIALILSYLDPQKASFILSSLPTEVQTNVARRIALMDRTSPEVVREVERV 188

Query: 184 VERCMLMAMEKSHTQISGVRQVADILNRFN-GDREQLMEMLKLHDKQLASSVADNMFDFI 242
+E+ + + +T GV V +I+N + + ++E L+ D +LA + MF F
Sbjct: 189 LEKKLASLSSEDYTSAGGVDNVVEIINMADRKTEKFIIESLEEEDPELAEEIKKKMFVFE 248

Query: 243 ILGRQKQETLQEIMSTVPSEVLAFALKGIDAELKTTLLTALPKRMSSAIETQVEAIGTIP 302
+ ++Q ++ + + LA ALK +D ++ + + KR +S ++ +E +G
Sbjct: 249 DIVLLDDRSIQRVLREIDGQELAKALKSVDIPVQEKIFKNMSKRAASMLKEDMEFLGPTR 308

Query: 303 LSQAVAARKEIMEIAKQMADEGLIELQLFEEQVV 336
++++I+ + +++ ++G I + E+ V
Sbjct: 309 RKDVEESQQKIVSLIRKLEEQGEIVISRGGEEDV 342


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0083FLGMRINGFLIF3063e-99 Flagellar M-ring protein signature.
		>FLGMRINGFLIF#Flagellar M-ring protein signature.

Length = 559

Score = 306 bits (784), Expect = 3e-99
Identities = 164/588 (27%), Positives = 270/588 (45%), Gaps = 70/588 (11%)

Query: 9 SPAATNAGVNNPLNSLKEKWQQYNRGDRQVVILAVLAIVAACVIVLMLWSASQGYRPLYG 68
S A+ A PL W R + ++ ++ + A V+ ++LW+ + YR L+
Sbjct: 1 SATASTATQPKPLE-----WLNRLRANPRIPLIVAGSAAVAIVVAMVLWAKTPDYRTLFS 55

Query: 69 NQEGVETSQIIEVLEAEGISYRIDANSGLILVTEDKLGPARMLLAARGVKAKVPSGMESL 128
N + I+ L I YR SG I V DK+ R+ LA +G+ G E L
Sbjct: 56 NLSDQDGGAIVAQLTQMNIPYRFANGSGAIEVPADKVHELRLRLAQQGLPKGGAVGFELL 115

Query: 129 ENSNIGTSQFMEQAKYRYSLEGELSRTIMALKAVKTARVHLAIPKKTLFIRQQPELPTAS 188
+ G SQF EQ Y+ +LEGEL+RTI L VK+ARVHLA+PK +LF+R+Q + P+AS
Sbjct: 116 DQEKFGISQFSEQVNYQRALEGELARTIETLGPVKSARVHLAMPKPSLFVREQ-KSPSAS 174

Query: 189 VMLELYAGSNIQPEQIESIVNLVAGSVTGMTPDRVQVVDQEGNHLSSSISVNKDITQARD 248
V + L G + QI ++V+LV+ +V G+ P V +VDQ G+ L+ S + +D D
Sbjct: 175 VTVTLEPGRALDEGQISAVVHLVSSAVAGLPPGNVTLVDQSGHLLTQSNTSGRD---LND 231

Query: 249 RQLKYTQELEQSLIDRASSMLLPILGRDHFEVQVAANVNFNQVEETKESLDP------LA 302
QLK+ ++E + R ++L PI+G + QV A ++F E+T+E P
Sbjct: 232 AQLKFANDVESRIQRRIEAILSPIVGNGNVHAQVTAQLDFANKEQTEEHYSPNGDASKAT 291

Query: 303 VVTKENLTSNETNSDMALGIPGALSNQPPAAEADESNAR--------------------- 341
+ +++ S + + G+PGALSNQP
Sbjct: 292 LRSRQLNISEQVGAGYPGGVPGALSNQPAPPNEAPIATPPTNQQNAQNTPQTSTSTNSNS 351

Query: 342 ---RNLNSQESRQFDTGRSVRHTRYQQMQLENLSVSVLINKQSAGETG---WTQTQLDQL 395
R+ E+ ++ R++RHT+ +E LSV+V++N ++ + T Q+ Q+
Sbjct: 352 AGPRSTQRNETSNYEVDRTIRHTKMNVGDIERLSVAVVVNYKTLADGKPLPLTADQMKQI 411

Query: 396 SSMVQDAIGFSAARGDQFSINSFDFAP--TQIAEFEPMPWWQGESYQTYLRYFIGALLGL 453
+ ++A+GFS RGD ++ + F+ E +P+WQ +S+ L LL L
Sbjct: 412 EDLTREAMGFSDKRGDTLNVVNSPFSAVDNTGGE---LPFWQQQSFIDQLLAAGRWLLVL 468

Query: 454 AMIFFVLRPLVKHLTKTVEHNLKSIDEPAQPSLPPAQATVTKLEG-GNNAQAIADQLIGQ 512
+ + + R V+ K+ E AQ +A +L Q A+Q +G
Sbjct: 469 VVAWILWRKAVRPQLTRRVEEAKAAQEQAQVRQETEEAVEVRLSKDEQLQQRRANQRLGA 528

Query: 513 NQKTGDLNWSGDASLPEPSSPLAVKMEHLSLLANQEPARVAEVIAHWI 560
V + + +++ +P VA VI W+
Sbjct: 529 E----------------------VMSQRIREMSDNDPRVVALVIRQWM 554


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0084FLGHOOKFLIE502e-11 Flagellar hook-basal body complex protein FliE signa...
		>FLGHOOKFLIE#Flagellar hook-basal body complex protein FliE

signature.
Length = 103

Score = 50.0 bits (119), Expect = 2e-11
Identities = 23/73 (31%), Positives = 34/73 (46%), Gaps = 1/73 (1%)

Query: 41 PSFTELMKNKVAAVNTDQNASAALMRAVDTGQSG-DLVGAMVASQKAGLAFSTMIQIRNR 99
SF + + ++ Q A+ G+ G L M QKA ++ IQ+RN+
Sbjct: 31 ISFAGQLHAALDRISDTQTAARTQAEKFTLGEPGVALNDVMTDMQKASVSMQMGIQVRNK 90

Query: 100 LVQAFDEVMKMPV 112
LV A+ EVM M V
Sbjct: 91 LVAAYQEVMSMQV 103


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0085HTHFIS378e-130 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 378 bits (972), Expect = e-130
Identities = 144/401 (35%), Positives = 214/401 (53%), Gaps = 47/401 (11%)

Query: 74 ELASIAMQCGVQDYLLLPIDAEQLCSLLQR--------LRRLELPNNE---LICAAPVSR 122
A A + G DYL P D +L ++ R +LE + + L+ + +
Sbjct: 88 MTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKRRPSKLEDDSQDGMPLVGRSAAMQ 147

Query: 123 QLLMLAHRAASTEATVLLTGESGTGKEPLARYIHRHSNRADKAFIAINCAAIPESILESI 182
++ + R T+ T+++TGESGTGKE +AR +H + R + F+AIN AAIP ++ES
Sbjct: 148 EIYRVLARLMQTDLTLMITGESGTGKELVARALHDYGKRRNGPFVAINMAAIPRDLIESE 207

Query: 183 LFGHIKGAFTGATTDQPGKFELANGGTLLLDEIGEMPLLLQAKLLRVLQEREVERLGSHR 242
LFGH KGAFTGA T G+FE A GGTL LDEIG+MP+ Q +LLRVLQ+ E +G
Sbjct: 208 LFGHEKGAFTGAQTRSTGRFEQAEGGTLFLDEIGDMPMDAQTRLLRVLQQGEYTTVGGRT 267

Query: 243 SIALDIRVIAATNKDLRQAVQDGKFREDLFYRLDVLPIKILPLRQRREDILPIAEHFLQR 302
I D+R++AATNKDL+Q++ G FREDL+YRL+V+P+++ PLR R EDI + HF+Q+
Sbjct: 268 PIRSDVRIVAATNKDLKQSINQGLFREDLYYRLNVVPLRLPPLRDRAEDIPDLVRHFVQQ 327

Query: 303 YKILAANQQCYFSEQARNLLLSHNWPGNVRELENTIQRALVMRRGQALQAEDLGLENQDG 362
+ + + F ++A L+ +H WPGNVRELEN ++R + + E + E +
Sbjct: 328 AEKEGLDVKR-FDQEALELMKAHPWPGNVRELENLVRRLTALYPQDVITREIIENELRSE 386

Query: 363 ------------------SILVEQNELG--------------LKASKRQAEFQYIIDTLK 390
S VE+N + E+ I+ L
Sbjct: 387 IPDSPIEKAAARSGSLSISQAVEENMRQYFASFGDALPPSGLYDRVLAEMEYPLILAALT 446

Query: 391 RHNGHRIQTAEALGMTTRALRYKLAQMREEGIDIERLLAQA 431
G++I+ A+ LG+ LR K +RE G+ + R A
Sbjct: 447 ATRGNQIKAADLLGLNRNTLRKK---IRELGVSVYRSSRSA 484


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0086OMPADOMAIN662e-14 OMPA domain signature.
		>OMPADOMAIN#OMPA domain signature.

Length = 346

Score = 65.7 bits (160), Expect = 2e-14
Identities = 32/111 (28%), Positives = 43/111 (38%), Gaps = 10/111 (9%)

Query: 180 EFLFAPSSSLLNAAHEQDLYAVYRYL-QADPSIVEVLVDGHADASGDHLANLVLSKERAD 238
+ LF + + L + L +Y L DP V+V G+ D G N LS+ RA
Sbjct: 220 DVLFNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGLSERRAQ 279

Query: 239 EVVSRLIELGVSPKMIQTRHHGTRTPVASNNSTQGR---------ELNRRV 280
VV LI G+ I R G PV N + +RRV
Sbjct: 280 SVVDYLISKGIPADKISARGMGESNPVTGNTCDNVKQRAALIDCLAPDRRV 330


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0087FLGMOTORFLIM310.004 Flagellar motor switch protein FliM signature.
		>FLGMOTORFLIM#Flagellar motor switch protein FliM signature.

Length = 344

Score = 31.4 bits (71), Expect = 0.004
Identities = 15/67 (22%), Positives = 27/67 (40%), Gaps = 3/67 (4%)

Query: 206 DPALSEKLAHRLRQIPLRVLLELGHQSTSLTSLQNLAVGDVLPMN-LHSRCPVT--VGKR 262
L +L + + V+ E+G S+ + L VGD++ ++ H P +G R
Sbjct: 243 TTQYMGVLRDKLSTVDMDVVAEVGSLRLSVRDILGLRVGDIIRLHDTHVGDPFVLSIGNR 302

Query: 263 PLFYATV 269
F
Sbjct: 303 KKFLCQP 309


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0088FLGMOTORFLIN814e-23 Flagellar motor switch protein FliN signature.
		>FLGMOTORFLIN#Flagellar motor switch protein FliN signature.

Length = 137

Score = 81.1 bits (200), Expect = 4e-23
Identities = 41/121 (33%), Positives = 68/121 (56%), Gaps = 16/121 (13%)

Query: 4 HNILQDEDFLLDD---EFFTEEESHQSKSQAK-------------PVKDMSFFHQLPVQV 47
+N + LDD + E+++ +KS A ++D+ +PV++
Sbjct: 5 NNPSDENTGALDDLWADALNEQKATTTKSAADAVFQQLGGGDVSGAMQDIDLIMDIPVKL 64

Query: 48 TLELASAEMSLGELTKMGEGDVVALDRMVGEPLDIRVNGALLGRGEVVEVNGRYGVRLLE 107
T+EL M++ EL ++ +G VVALD + GEPLDI +NG L+ +GEVV V +YGVR+ +
Sbjct: 65 TVELGRTRMTIKELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVVADKYGVRITD 124

Query: 108 V 108
+
Sbjct: 125 I 125


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0089FLGBIOSNFLIP2431e-83 Escherichia coli: Flagellar biosynthetic protein Fl...
		>FLGBIOSNFLIP#Escherichia coli: Flagellar biosynthetic protein FliP

signature.
Length = 245

Score = 243 bits (623), Expect = 1e-83
Identities = 115/238 (48%), Positives = 165/238 (69%)

Query: 4 VLLILLLGFSSTAYANDGLTLFTLNDGAESESVSVKLEILALMTVLSFLPAMLMMLTSFT 63
+ +LL + + + +S S+ ++ L +T L+F+PA+L+M+TSFT
Sbjct: 6 SVAPVLLWLITPLAFAQLPGITSQPLPGGGQSWSLPVQTLVFITSLTFIPAILLMMTSFT 65

Query: 64 RIIVVLGILRQALGLQQSPPNKVLIGIALVMTIFIMRPVGEEIYEKAFLPYDQGIIELPE 123
RII+V G+LR ALG +PPN+VL+G+AL +T FIM PV ++IY A+ P+ + I + E
Sbjct: 66 RIIIVFGLLRNALGTPSAPPNQVLLGLALFLTFFIMSPVIDKIYVDAYQPFSEEKISMQE 125

Query: 124 AVERGEKPLRQFMLAQTRETDLEQMLKIADEPTTLTAEEIPFFVLMPAYVLSELKTAFQI 183
A+E+G +PLR+FML QTRE DL ++A+ E +P +L+PAYV SELKTAFQI
Sbjct: 126 ALEKGAQPLREFMLRQTREADLGLFARLANTGPLQGPEAVPMRILLPAYVTSELKTAFQI 185

Query: 184 GFLLFLPFLVIDLVVASVLMSMGMMMLSPLIISLPFKLMVFVLVDGWSMTVSTLVASY 241
GF +F+PFL+IDLV+ASVLM++GMMM+ P I+LPFKLM+FVLVDGW + V +L S+
Sbjct: 186 GFTIFIPFLIIDLVIASVLMALGMMMVPPATIALPFKLMLFVLVDGWQLLVGSLAQSF 243


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0090TYPE3IMQPROT485e-11 Type III secretion system inner membrane Q protein ...
		>TYPE3IMQPROT#Type III secretion system inner membrane Q protein

family signature.
Length = 86

Score = 47.8 bits (114), Expect = 5e-11
Identities = 20/80 (25%), Positives = 41/80 (51%)

Query: 3 VNELTSFFADAVFLVIAMVGVLVLPSLLVGLVVAVFQAATQVNEQTLSFLPRLVITLLMV 62
+++L A++LV+ + G + + ++GL+V +FQ TQ+ EQTL F +L+ L +
Sbjct: 1 MDDLVFAGNKALYLVLILSGWPTIVATIIGLLVGLFQTVTQLQEQTLPFGIKLLGVCLCL 60

Query: 63 LFAGEWMLMQMSDLFQRLFL 82
W + +++
Sbjct: 61 FLLSGWYGEVLLSYGRQVIF 80


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0091TYPE3IMRPROT1211e-35 Type III secretion system inner membrane R protein ...
		>TYPE3IMRPROT#Type III secretion system inner membrane R protein

family signature.
Length = 261

Score = 121 bits (306), Expect = 1e-35
Identities = 75/256 (29%), Positives = 133/256 (51%), Gaps = 2/256 (0%)

Query: 1 MLSLTSTELSTFIGTFWWPFCRIMGAFMVMPFLSSTYIPVTVRILLALTLSALIAPMLPP 60
ML +TS + +++ ++WP R++ P LS +P V++ LA+ ++ IAP LP
Sbjct: 1 MLQVTSEQWLSWLNLYFWPLLRVLALISTAPILSERSVPKRVKLGLAMMITFAIAPSLPA 60

Query: 61 LPEVDAISIQALLLAIEQLLVGFMMALFLTIMLYVMTQLGEMLSMQMGLAMAVMNDPSSG 120
S AL LA++Q+L+G + + + GE++ +QMGL+ A DP+S
Sbjct: 61 NDVPV-FSFFALWLAVQQILIGIALGFTMQFAFAAVRTAGEIIGLQMGLSFATFVDPASH 119

Query: 121 GSHPILGQWFLLYGTLVFLVLDGHLVAIGVLVDSFRLWPVG-MGVFDLPLMGLIGRISWL 179
+ P+L + + L+FL +GHL I +LVD+F P+G + + L S +
Sbjct: 120 LNMPVLARIMDMLALLLFLTFNGHLWLISLLVDTFHTLPIGGEPLNSNAFLALTKAGSLI 179

Query: 180 FAVSFMLAIPSILAMLMVNITFGVLSRSAPSLNVFALGFPMSMLMGLLCVFFSFSGLPSR 239
F MLA+P I +L +N+ G+L+R AP L++F +GFP+++ +G+ + +
Sbjct: 180 FLNGLMLALPLITLLLTLNLALGLLNRMAPQLSIFVIGFPLTLTVGISLMAALMPLIAPF 239

Query: 240 YSDLCLDALSAMYQFI 255
L + + + I
Sbjct: 240 CEHLFSEIFNLLADII 255


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0092TYPE3IMSPROT314e-107 Type III secretion system inner membrane S protein ...
		>TYPE3IMSPROT#Type III secretion system inner membrane S protein

family signature.
Length = 354

Score = 314 bits (805), Expect = e-107
Identities = 113/349 (32%), Positives = 184/349 (52%), Gaps = 6/349 (1%)

Query: 9 KTEDATPKKLKQAREQGQVPRSKDFTSAALVMGCALLLTTSAGEIGARVAQLARTNMQFT 68
KTE TPKK++ AR++GQV +SK+ S AL++ + +L + ++L M
Sbjct: 5 KTEQPTPKKIRDARKKGQVAKSKEVVSTALIVALSAMLMGLSDYYFEHFSKL----MLIP 60

Query: 69 KAQ--LDEPGMMTRHLGQALLEILYILAPLFILVALIAMIAGAMPGGWIFNFGNAGFKYS 126
Q L ++ + LLE Y+ PL + AL+A+ + + G++ +
Sbjct: 61 AEQSYLPFSQALSYVVDNVLLEFFYLCFPLLTVAALMAIASHVVQYGFLISGEAIKPDIK 120

Query: 127 RIDPIAGLGRMVSIKSLAELIKSVLKIVLLGGIMLVFLDKNLQTLLTFSQLPIDEAITRV 186
+I+PI G R+ SIKSL E +KS+LK+VLL ++ + + NL TLL I+ +
Sbjct: 121 KINPIEGAKRIFSIKSLVEFLKSILKVVLLSILIWIIIKGNLVTLLQLPTCGIECITPLL 180

Query: 187 IDMLSLGVFYLGLGLLFIACIDLPYQYWQHHNELKMSLQEVKDEHKQQEGKPEIKAKIRQ 246
+L + +G + I+ D ++Y+Q+ ELKMS E+K E+K+ EG PEIK+K RQ
Sbjct: 181 GQILRQLMVICTVGFVVISIADYAFEYYQYIKELKMSKDEIKREYKEMEGSPEIKSKRRQ 240

Query: 247 MQQRISRSRADVSIPNADVLLVNPTHYAVALKYDANKADAPYVLTKGTDELALYMREVAK 306
Q I ++ + V++ NPTH A+ + Y + P V K TD +R++A+
Sbjct: 241 FHQEIQSRNMRENVKRSSVVVANPTHIAIGILYKRGETPLPLVTFKYTDAQVQTVRKIAE 300

Query: 307 RHGVEILELPPLTRAIYYSTNIEQQIPASLFVAIAHVLTYVMQIRAARQ 355
GV IL+ PL RA+Y+ ++ IPA A A VL ++ + +Q
Sbjct: 301 EEGVPILQRIPLARALYWDALVDHYIPAEQIEATAEVLRWLERQNIEKQ 349


62Spea_0143Spea_0150N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_01432130.415285general secretion pathway protein C
Spea_01442120.526824general secretion pathway protein D
Spea_01451160.982560general secretory pathway protein E
Spea_0146-1160.548252general secretion pathway protein F
Spea_0147-1170.775520general secretion pathway protein G
Spea_0148-1180.945797general secretion pathway protein H
Spea_0149-1190.507386general secretion pathway protein I
Spea_0150-1180.371910general secretion pathway protein J
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0143BCTERIALGSPC1961e-63 Bacterial general secretion pathway protein C signa...
		>BCTERIALGSPC#Bacterial general secretion pathway protein C

signature.
Length = 272

Score = 196 bits (499), Expect = 1e-63
Identities = 75/284 (26%), Positives = 134/284 (47%), Gaps = 32/284 (11%)

Query: 17 KPVSTAIFSIGLLIVLYLLAQITWKL-VPDDSTQARWVPTPVSSNAAGQVNILNLQQLSL 75
+ +F + +L+ LA I W++ +PD++ + TP + L +L
Sbjct: 12 SVIRRILFYLLMLLFCQQLAMIFWRIGLPDNAPVSSVQITPAQARQQPVT----LNDFTL 67

Query: 76 FGKPDAAGNKPKAAAIEEIITDAPKTSLSIQLTGVVASTTEQKGLAVIASSGSQDTYGLG 135
FG A +++ P ++L++ LTGV+A + + +A+I+ Q + G+
Sbjct: 68 FGVSPEKNKAGALDA--SQMSNLPPSTLNLSLTGVMAGDDDSRSIAIISKDNEQFSRGVN 125

Query: 136 DKIKGTSASLKEVYADRIIITNSGRYETLMLDGLEYNTNGTANQQLQKAKSVSKGKTIDN 195
+++ G +A + + DR+++ GRYE L L E + G ++
Sbjct: 126 EEVPGYNAKIVSIRPDRVVLQYQGRYEVLGLYSQEDS-----------GSDGVPGAQVN- 173

Query: 196 RNNRAVAAELSQSRDEILADPSKITDYLSISPVKSGGELAGYRLNPGKDRELFKQAGFRA 255
E Q R + ++DY+S SP+ + +L GYRLNPG + F + G +
Sbjct: 174 --------EQLQQRA-----STTMSDYVSFSPIMNDNKLQGYRLNPGPKSDSFYRVGLQD 220

Query: 256 NDLAKSINGYDLTDMGQALEVMAQLPEMTEVALMVERDGQLIEI 299
ND+A ++NG DL D QA + M ++ ++ L VERDGQ +I
Sbjct: 221 NDMAVALNGLDLRDAEQAKKAMERMADVHNFTLTVERDGQRQDI 264


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0144BCTERIALGSPD6100.0 Bacterial general secretion pathway protein D signa...
		>BCTERIALGSPD#Bacterial general secretion pathway protein D

signature.
Length = 660

Score = 610 bits (1574), Expect = 0.0
Identities = 333/677 (49%), Positives = 448/677 (66%), Gaps = 29/677 (4%)

Query: 6 IRRRLIAGMVMGASLLAPQLAWSEQYAANFKGTDIQEFINIVGKNLNRTIIVDPTVRGKI 65
IR + ++ A L P A +E+++A+FKGTDIQEFIN V KNLN+T+I+DP+VRG I
Sbjct: 7 IRSFSLTLLIFAALLFRP--AAAEEFSASFKGTDIQEFINTVSKNLNKTVIIDPSVRGTI 64

Query: 66 NVRSYDLLNDEQYYQFFLNVLQVYGYAVVEMDNNIIKVIKDKDAKTASIRVADDDAPGLG 125
VRSYD+LN+EQYYQFFL+VL VYG+AV+ M+N ++KV++ KDAKTA++ VA D APG+G
Sbjct: 65 TVRSYDMLNEEQYYQFFLSVLDVYGFAVINMNNGVLKVVRSKDAKTAAVPVASDAAPGIG 124

Query: 126 DEMVTRIVALYNTEAKQLAPLLRQLNDNAGGGNVVNYDPSNVLMISGRAAVVNKLVEIVR 185
DE+VTR+V L N A+ LAPLLRQLNDNAG G+VV+Y+PSNVL+++GRAAV+ +L+ IV
Sbjct: 125 DEVVTRVVPLTNVAARDLAPLLRQLNDNAGVGSVVHYEPSNVLLMTGRAAVIKRLLTIVE 184

Query: 186 RVDKQGDTAVEVVKLEYASAGEIVRIIDTLYRSTANQAQMPGQAPKVVADERTNAVVVSG 245
RVD GD +V V L +ASA ++V+++ L + T+ A VVADERTNAV+VSG
Sbjct: 185 RVDNAGDRSVVTVPLSWASAADVVKLVTELNKDTSKSALPGSMVANVVADERTNAVLVSG 244

Query: 246 DEKSRERVVKLIKNLDAEQASTGNTKVRYLRYAKAEDLVEVLTGFAEQLVDDKGTSQGGG 305
+ SR+R++ +IK LD +QA+ GNTKV YL+YAKA DLVEVLTG + + +K ++
Sbjct: 245 EPNSRQRIIAMIKQLDRQQATQGNTKVIYLKYAKASDLVEVLTGISSTMQSEKQAAKPVA 304

Query: 306 SKRRNEINIMAHNDTNALVISAEPDQMRTIESVINQLDIRRAQVLVEAIIVEVGEGDDVG 365
+ +N I I AH TNAL+++A PD M +E VI QLDIRR QVLVEAII EV + D +
Sbjct: 305 ALDKN-IIIKAHGQTNALIVTAAPDVMNDLERVIAQLDIRRPQVLVEAIIAEVQDADGLN 363

Query: 366 FGVQWATEAGGGTQFNNLGPTIGEIGAGVWQAQGEEGSTVCNDGTCTENPDTRGDITLLA 425
G+QWA + G TQF N G I AG + DGT + + LA
Sbjct: 364 LGIQWANKNAGMTQFTNSGLPISTAIAG--------ANQYNKDGTVS---------SSLA 406

Query: 426 QALGKVNGMAWGVAMGDFAALIQAVSSDTKSNVLATPSITTLDNQEASFIVGDEVPILTG 485
AL NG+A G G++A L+ A+SS TK+++LATPSI TLDN EA+F VG EVP+LTG
Sbjct: 407 SALSSFNGIAAGFYQGNWAMLLTALSSSTKNDILATPSIVTLDNMEATFNVGQEVPVLTG 466

Query: 486 SQNSSNGNSNPFQTVERKEVGVKLKVVPQINEGSSVKLTIEQEVSGINGK-----TGVDV 540
SQ +S N F TVERK VG+KLKV PQINEG SV L IEQEVS + + +
Sbjct: 467 SQTTSGD--NIFNTVERKTVGIKLKVKPQINEGDSVLLEIEQEVSSVADAASSTSSDLGA 524

Query: 541 TFATRRLTTTVMADSGQIVVLGGLIKEEVQESVQKVPFLGDIPIIGHLFKSSSSGKKKTN 600
TF TR + V+ SG+ VV+GGL+ + V ++ KVP LGDIP+IG LF+S+S K N
Sbjct: 525 TFNTRTVNNAVLVGSGETVVVGGLLDKSVSDTADKVPLLGDIPVIGALFRSTSKKVSKRN 584

Query: 601 LMVFIKPTIIRDGMTMEGIAGRKYNYFRALQLEQQ-ERGVNLMPNTDVPILEEWNQADYL 659
LM+FI+PT+IRD + +Y F Q +Q+ + + M N D+ + Q
Sbjct: 585 LMLFIRPTVIRDRDEYRQASSGQYTAFNDAQSKQRGKENNDAMLNQDLLEIYP-RQDTAA 643

Query: 660 PPEVNDVLNRYKEGKGL 676
+V+ ++ + G L
Sbjct: 644 FRQVSAAIDAFNLGGNL 660


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0146BCTERIALGSPF502e-180 Bacterial general secretion pathway protein F signa...
		>BCTERIALGSPF#Bacterial general secretion pathway protein F

signature.
Length = 408

Score = 502 bits (1293), Expect = e-180
Identities = 230/407 (56%), Positives = 302/407 (74%), Gaps = 1/407 (0%)

Query: 1 MPAFEYKALDKTGKQKKGVVEADTARHARTQLREQRLMPLEITPVVEKESKTKAAGFSF- 59
M + Y+ALD GK+ +G EAD+AR AR LRE+ L+PL + + K+ + G S
Sbjct: 1 MAQYHYQALDAQGKKCRGTQEADSARQARQLLRERGLVPLSVDENRGDQQKSGSTGLSLR 60

Query: 60 LKRGISTAELALITRQIATLVAAGLPVEEALKAVGQQCEKDRLASMVMAVRSRVVEGYSL 119
K +ST++LAL+TRQ+ATLVAA +P+EEAL AV +Q EK L+ ++ AVRS+V+EG+SL
Sbjct: 61 RKIRLSTSDLALLTRQLATLVAASMPLEEALDAVAKQSEKPHLSQLMAAVRSKVMEGHSL 120

Query: 120 ADSMAEFPHIFDELYRAMVASGEKSGHLEVVLNRLADYTERRQQLKSKMTQAMIYPIVLT 179
AD+M FP F+ LY AMVA+GE SGHL+ VLNRLADYTE+RQQ++S++ QAMIYP VLT
Sbjct: 121 ADAMKCFPGSFERLYCAMVAAGETSGHLDAVLNRLADYTEQRQQMRSRIQQAMIYPCVLT 180

Query: 180 VVAIGVIAILLAAVVPQVVGQFEHMGQELPWTTELLIASSDFIRDYGLIVLAVIVGLFFI 239
VVAI V++ILL+ VVP+VV QF HM Q LP +T +L+ SD +R +G +L ++ F
Sbjct: 181 VVAIAVVSILLSVVVPKVVEQFIHMKQALPLSTRVLMGMSDAVRTFGPWMLLALLAGFMA 240

Query: 240 AKRLLVSPKNRMKYDSMLLRLPVISKVSKSLNTARFARTLSILTASSVPLLDAMRIASDV 299
+ +L K R+ + LL LP+I ++++ LNTAR+ARTLSIL AS+VPLL AMRI+ DV
Sbjct: 241 FRVMLRQEKRRVSFHRRLLHLPLIGRIARGLNTARYARTLSILNASAVPLLQAMRISGDV 300

Query: 300 LINVKVKAAVEDATLRVREGTSLGTALANTKLFPPMMLYMITSGEKSGQLEQMLERAADN 359
+ N + + AT VREG SL AL T LFPPMM +MI SGE+SG+L+ MLERAADN
Sbjct: 301 MSNDYARHRLSLATDAVREGVSLHKALEQTALFPPMMRHMIASGERSGELDSMLERAADN 360

Query: 360 QDRDFESNVTIALGVFEPMLVVSMAAVVLFIVLAILQPILALNNMIS 406
QDR+F S +T+ALG+FEP+LVVSMAAVVLFIVLAILQPIL LN ++S
Sbjct: 361 QDREFSSQMTLALGLFEPLLVVSMAAVVLFIVLAILQPILQLNTLMS 407


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0147BCTERIALGSPG2361e-83 Bacterial general secretion pathway protein G signa...
		>BCTERIALGSPG#Bacterial general secretion pathway protein G

signature.
Length = 145

Score = 236 bits (603), Expect = 1e-83
Identities = 100/144 (69%), Positives = 122/144 (84%)

Query: 1 MQARNKQKGFTLLEVMVVIVILGILASMVVPNLMGNKDKADQQKAVSDIVALENALDMYK 60
M+A +KQ+GFTLLE+MVVIVI+G+LAS+VVPNLMGNK+KAD+QKAVSDIVALENALDMYK
Sbjct: 1 MRATDKQRGFTLLEIMVVIVIIGVLASLVVPNLMGNKEKADKQKAVSDIVALENALDMYK 60

Query: 61 LDNSVYPTTEQGLEALVQKPTISPEPRNYRADGYVKRLPQDPWRNDYLLLSPGENGKLDI 120
LDN YPTT QGLE+LV+ PT+ P NY +GY+KRLP DPW NDY+L++PGE+G D+
Sbjct: 61 LDNHHYPTTNQGLESLVEAPTLPPLAANYNKEGYIKRLPADPWGNDYVLVNPGEHGAYDL 120

Query: 121 FSSGPDGQAGTEDDIGNWNLQNFQ 144
S+GPDG+ GTEDDI NW L +
Sbjct: 121 LSAGPDGEMGTEDDITNWGLSKKK 144


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0148BCTERIALGSPH832e-22 Bacterial general secretion pathway protein H signa...
		>BCTERIALGSPH#Bacterial general secretion pathway protein H

signature.
Length = 170

Score = 83.5 bits (206), Expect = 2e-22
Identities = 37/170 (21%), Positives = 69/170 (40%), Gaps = 39/170 (22%)

Query: 23 RQTGFTLMEVLLVVLLMGLAATAVTLGMGGASKEKALERTAQQFMMSTEMVLDETVLSGH 82
RQ GFTL+E++L++LLMG++A V L + + A + T +F V + +G
Sbjct: 2 RQRGFTLLEMMLILLLMGVSAGMVLLAFPASRDDSAAQ-TLARFEAQLRFVQQRGLQTGQ 60

Query: 83 FVGIVIEDNSYKYVYYDEG---------------KWKPLEQDRLLAERQMEPGVEMVLVL 127
F G+ + + ++++ + +W PL R+ +
Sbjct: 61 FFGVSVHPDRWQFLVLEARDGADPAPADDGWSGYRWLPLRAGRVATSGS----------I 110

Query: 128 DGLPLVQDDEEQDSWFDEPLIEKSADEKKKFPEPQIMLFPSGEMSAFELS 177
G L + ++W P +++FP GEM+ F L+
Sbjct: 111 AGGKLNLAFAQGEAW-------------TPGDNPDVLIFPGGEMTPFRLT 147


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0149PilS_PF08805319e-04 PilS N terminal
		>PilS_PF08805#PilS N terminal

Length = 185

Score = 30.7 bits (69), Expect = 9e-04
Identities = 13/54 (24%), Positives = 23/54 (42%)

Query: 3 RRTDQTGMTLLEVIVALAVFSIAAVSITKSLGEQMANMPILEERTMAQWVAHNK 56
++ G TL+EV++ + V + A S K +N+ E+ V N
Sbjct: 21 KKEQDKGATLMEVLLVVGVIVVLAASAYKLYSMVQSNIQSSNEQNNVLTVIANM 74


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0150BCTERIALGSPG371e-05 Bacterial general secretion pathway protein G signa...
		>BCTERIALGSPG#Bacterial general secretion pathway protein G

signature.
Length = 145

Score = 37.2 bits (86), Expect = 1e-05
Identities = 21/55 (38%), Positives = 33/55 (60%), Gaps = 7/55 (12%)

Query: 3 LRLTKSQRGFTLLEMLIAIAIFAMLGLAANTVLSTVMKNDTATRDFAAKLKAMQQ 57
+R T QRGFTLLE+++ I I +G+ A+ V+ +M N ++ A K KA+
Sbjct: 1 MRATDKQRGFTLLEIMVVIVI---IGVLASLVVPNLMGN----KEKADKQKAVSD 48


63Spea_0357Spea_0375N        Y        YPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_0357-212-0.065285acriflavin resistance protein
Spea_0358-112-1.234819RND family efflux transporter MFP subunit
Spea_0359012-1.385809TetR family transcriptional regulator
Spea_0360-111-0.866851ATP-dependent DNA helicase Rep
Spea_0361013-1.144950GAF sensor-containing diguanylate
Spea_0362-1120.337439****diguanylate cyclase/phosphodiesterase
Spea_03634190.285984hypothetical protein
Spea_03644180.459133OmpA/MotB domain-containing protein
Spea_03654180.440214TolC family type I secretion outer membrane
Spea_03663180.345379HlyD family type I secretion membrane fusion
Spea_03673180.352072ABC transporter-like protein
Spea_03684200.275105cadherin
Spea_03690100.558476outer membrane adhesin-like protein
Spea_03703110.340004HemY domain-containing protein
Spea_03712110.516917hypothetical protein
Spea_03721141.359561uroporphyrinogen III synthase HEM4
Spea_03731161.804625porphobilinogen deaminase
Spea_03742221.532364adenylate cyclase
Spea_03752212.060664frataxin family protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0357ACRIFLAVINRP7990.0 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 799 bits (2064), Expect = 0.0
Identities = 310/1029 (30%), Positives = 534/1029 (51%), Gaps = 34/1029 (3%)

Query: 5 DIFIRRPVLAASISFLILLLGFYALKSMQVREYPEMTNTVVTISTSYYGADSNLIQGFIT 64
+ FIRRP+ A ++ ++++ G A+ + V +YP + V++S +Y GAD+ +Q +T
Sbjct: 3 NFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDTVT 62

Query: 65 QPLEQALAQADNVDFMTSDSF-LGSSKITVYMKLNTDPNGALADILAKVNSVRSQLPKEA 123
Q +EQ + DN+ +M+S S GS IT+ + TDP+ A + K+ LP+E
Sbjct: 63 QVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQEV 122

Query: 124 EDPTVEMSTGSQTSALYISFYSDQINSSQ--ITDYLERVVKPELFTIDGVAKVNLYGGIK 181
+ + + S + + F SD ++Q I+DY+ VK L ++GV V L+G +
Sbjct: 123 QQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGA-Q 181

Query: 182 YAMRIWLDPARMGAFNLSSTDVMSVLQANNYQSAVGQTNNTFTL------LNGTADTQVA 235
YAMRIWLD + + L+ DV++ L+ N Q A GQ T L + A T+
Sbjct: 182 YAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRFK 241

Query: 236 TVAELEKLVI-GSKNGLVIRLGDIATVNLEKSHDVYRALADGQEAVVVGLDVTPTANPLV 294
E K+ + + +G V+RL D+A V L + A +G+ A +G+ + AN L
Sbjct: 242 NPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANALD 301

Query: 295 VAADARAMMPQIERNLPVTMKTRILYDSSLAIDESINEVIKTIGEAALIVIVVITLFLGS 354
A +A + +++ P MK YD++ + SI+EV+KT+ EA ++V +V+ LFL +
Sbjct: 302 TAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQN 361

Query: 355 LRAVIIPIVTIPLSLIGVAIIMQMFGFTLNLMTLLAMVLAIGLVVDDAIVVVENVDRHIK 414
+RA +IP + +P+ L+G I+ FG+++N +T+ MVLAIGL+VDDAIVVVENV+R +
Sbjct: 362 MRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVMM 421

Query: 415 LGETPFRAAII-GTREIAVPVISMTITLAAVYAPIALMGGVTGSLFKEFALTLAGAVFIS 473
+ P + A +I ++ + + L+AV+ P+A GG TG+++++F++T+ A+ +S
Sbjct: 422 EDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALS 481

Query: 474 GIVALTLSPMMCSKILKA-----HSEPNRFERSVENFLEGLTSRYNRMLTAVLDKRPVII 528
+VAL L+P +C+ +LK H F + + Y + +L +
Sbjct: 482 VLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGRYL 541

Query: 529 GFAIIVFASLPVMFSFIPSELAPNEDKSVVMMMGTAPSSANLDYIQANMTLVTDMISAQP 588
++ A + V+F +PS P ED+ V + M P+ A + Q + VTD
Sbjct: 542 LIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYLKNE 601

Query: 589 EAAASLAF----VGVPNANQAFGIA--PLVPWSERDKSQKQMQEFFGK---EVKNVPGMA 639
+A F Q G+A L PW ER+ + + + E+ +
Sbjct: 602 KANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKIRDGF 661

Query: 640 VTTFQMPE--LPGASSGLPIQFVITSSTSFESLFQIGSGVLEQVQKSPLFVYS-EVNLKF 696
V F MP G ++G + + + ++L Q + +L + P + S N
Sbjct: 662 VIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRPNGLE 721

Query: 697 DSGSMKIHIKRDVAGAYGITMQDIGLTLTTMMSDGYVNRINLDGRSYEVIPQVERKLRAN 756
D+ K+ + ++ A A G+++ DI T++T + YVN GR ++ Q + K R
Sbjct: 722 DTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADAKFRML 781

Query: 757 PEALAGYYLTAADGRSVPLASLVDIEIVSEPRSLPHFNQMNAITVGGVAAPGVAIGDAIA 816
PE + Y+ +A+G VP ++ V L +N + ++ + G AAPG + GDA+A
Sbjct: 782 PEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAPGTSSGDAMA 841

Query: 817 FLKNIGDNELPKGYSYDFLGEARQYVTEGSALYATFGLALAIIFLVLASQFESLKDPLVI 876
++N+ ++LP G YD+ G + Q G+ A ++ ++FL LA+ +ES P+ +
Sbjct: 842 LMENL-ASKLPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYESWSIPVSV 900

Query: 877 LVSVPLAISGALVALGWTHVFGLSSMNIYTQVGLITLVGLITKHGILMCEVAKEEQLHNG 936
++ VPL I G L+A + ++Y VGL+T +GL K+ IL+ E AK+ G
Sbjct: 901 MLVVPLGIVGVLLAATLFN----QKNDVYFMVGLLTTIGLSAKNAILIVEFAKDLMEKEG 956

Query: 937 LSRADAIKHAATIRLRPILMTTAAMIAGLIPLLFASGAGAVARFNIGLVIVSGLAIGTVF 996
+A A +RLRPILMT+ A I G++PL ++GAG+ A+ +G+ ++ G+ T+
Sbjct: 957 KGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLL 1016

Query: 997 TLFVLPVIY 1005
+F +PV +
Sbjct: 1017 AIFFVPVFF 1025



Score = 76.0 bits (187), Expect = 5e-16
Identities = 72/378 (19%), Positives = 140/378 (37%), Gaps = 20/378 (5%)

Query: 651 ASSGLPIQFVITSSTSFESLFQIGSGVLEQVQKSPLFVYS---EVNLKFDSGSMKIHIKR 707
+SS + S + I V V K L + +V L +M+I +
Sbjct: 132 SSSSYLMVAGFVSDNPGTTQDDISDYVASNV-KDTLSRLNGVGDVQLFGAQYAMRIWLDA 190

Query: 708 DVAGAYGITMQDIGLTLTTMMSDGYVNRIN----LDGRSYEVIPQVERKLRANPEALAGY 763
D+ Y +T D+ L ++ L G+ + + + E
Sbjct: 191 DLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRFKNPEEFGKVT 250

Query: 764 YLTAADGRSVPLASLVDIEI-VSEPRSLPHFNQMNAITVGGVAAPG---VAIGDAI-AFL 818
+DG V L + +E+ + N A +G A G + AI A L
Sbjct: 251 LRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANALDTAKAIKAKL 310

Query: 819 KNIGDNELPKGYSYDFLGEARQYVTEG-SALYATFGLALAIIFLVLASQFESLKDPLVIL 877
+ P+G + + +V + T A+ ++FLV+ ++++ L+
Sbjct: 311 AELQPF-FPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQNMRATLIPT 369

Query: 878 VSVPLAISGALVALGWTHVFGLSSMNIYTQVGLITLVGLITKHGILMCEVAKEEQLHNGL 937
++VP+ + G L FG S +N T G++ +GL+ I++ E + + + L
Sbjct: 370 IAVPVVLLGTFAIL---AAFGYS-INTLTMFGMVLAIGLLVDDAIVVVENVERVMMEDKL 425

Query: 938 SRADAIKHAATIRLRPILMTTAAMIAGLIPLLFASGAGAVARFNIGLVIVSGLAIGTVFT 997
+A + + + ++ + A IP+ F G+ + IVS +A+ +
Sbjct: 426 PPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSVLVA 485

Query: 998 LFVLPVI-YTYLAEQHEP 1014
L + P + T L
Sbjct: 486 LILTPALCATLLKPVSAE 503


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0358RTXTOXIND446e-07 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 44.0 bits (104), Expect = 6e-07
Identities = 34/213 (15%), Positives = 77/213 (36%), Gaps = 24/213 (11%)

Query: 78 GVVSAIRFENGSQVQAGQMLVELDSKVEKANLKSKQVQLPAAEADYKRLSKLYKQNSISK 137
++ + + + + +V K+ L+ + ++ +A+ +Y+ +++L+K + K
Sbjct: 247 QAIAKHAVL---EQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDK 303

Query: 138 QDLDNSQSKYLALMADIESLSATIDRREIKAAFTGLVGIRNVN-LGEYLQTGT---DIVR 193
L + L ++ I+A + V V+ G + T IV
Sbjct: 304 --LRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTTAETLMVIVP 361

Query: 194 LEDISTMKIRFTIPQTQLPRIETGQVVHVHVDAYP---TEPFEGTISAIEP--------A 242
+D T+++ + + I GQ + V+A+P G + I
Sbjct: 362 EDD--TLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNINLDAIEDQRLG 419

Query: 243 VFYQSGLIQV--QALIPNSHGKLRSGMFAKVDI 273
+ + + N + L SGM +I
Sbjct: 420 LVFNVIISIEENCLSTGNKNIPLSSGMAVTAEI 452



Score = 43.7 bits (103), Expect = 8e-07
Identities = 20/100 (20%), Positives = 38/100 (38%), Gaps = 1/100 (1%)

Query: 72 IANEVAGVVSAIRFENGSQVQAGQMLVELDSKVEKANLKSKQVQLPAAEADYKRLSKLYK 131
I +V I + G V+ G +L++L + +A+ Q L A + R L +
Sbjct: 99 IKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSR 158

Query: 132 Q-NSISKQDLDNSQSKYLALMADIESLSATIDRREIKAAF 170
+L Y +++ E L T +E + +
Sbjct: 159 SIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTW 198


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0359HTHTETR704e-17 TetR bacterial regulatory protein HTH signature.
		>HTHTETR#TetR bacterial regulatory protein HTH signature.

Length = 215

Score = 70.0 bits (171), Expect = 4e-17
Identities = 32/146 (21%), Positives = 56/146 (38%), Gaps = 9/146 (6%)

Query: 19 ILRAAEKIIATGGIQGLSMQQVATEAGVAAGTIYRYFKDKNELILELRKDVLSQVAGAI- 77
IL A ++ + G+ S+ ++A AGV G IY +FKDK++L E+ + S +
Sbjct: 16 ILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSESNIGELEL 75

Query: 78 -LADHDLGTLEQRFKRIWMKMHNYGKQRTSTNLSYEQYAHLPES------NTNEIRQLEM 130
G + I + + L E H E R L +
Sbjct: 76 EYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQQAQRNLCL 135

Query: 131 ELFAPLQQLFEEGIKQGLIQP-LNPR 155
E + ++Q + I+ ++ L R
Sbjct: 136 ESYDRIEQTLKHCIEAKMLPADLMTR 161


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0364OMPADOMAIN761e-18 OMPA domain signature.
		>OMPADOMAIN#OMPA domain signature.

Length = 346

Score = 76.1 bits (187), Expect = 1e-18
Identities = 29/119 (24%), Positives = 52/119 (43%), Gaps = 14/119 (11%)

Query: 76 KILFANDSYYIDPQYYPQVEVIASFMQKF--PNTQAVIEGHCSKTGSHQHNQVLSQNRAN 133
+LF + + P+ ++ + S + + V+ G+ + GS +NQ LS+ RA
Sbjct: 220 DVLFNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGLSERRAQ 279

Query: 134 AVSSLLAERFGIDSGRLSAVGYSFDRPIDPTHTASAHK----------INRRVIAELTG 182
+V L + GI + ++SA G P+ +T K +RRV E+ G
Sbjct: 280 SVVDYLISK-GIPADKISARGMGESNPV-TGNTCDNVKQRAALIDCLAPDRRVEIEVKG 336


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0366RTXTOXIND2994e-99 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 299 bits (767), Expect = 4e-99
Identities = 93/441 (21%), Positives = 200/441 (45%), Gaps = 11/441 (2%)

Query: 20 MMTDAPTSHRLIIWALAALAVTFLVWAYFAELDQVTTGMGKVIPSSQVQVIQSLDGGILQ 79
+ T RL+ + + V + + +++ V T GK+ S + + I+ ++ I++
Sbjct: 49 IETPVSRRPRLVAYFIMGFLVIAFILSVLGQVEIVATANGKLTHSGRSKEIKPIENSIVK 108

Query: 80 EMYVQEGLIVTKGQPLVRIDATRFQSDFAQQEQEVNSLVANVVRLQAELNSITISGITND 139
E+ V+EG V KG L+++ A ++D + + + R Q SI ++
Sbjct: 109 EIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNK---- 164

Query: 140 WREQVKISPQPLIFPAALEEGDPKLTNRQREEYTGRLDNLSNQLEIQARQIQQRNQEIQE 199
++K+ +P + E + R + NQ + + ++ E
Sbjct: 165 -LPELKLPDEPY--FQNVSEEEVL---RLTSLIKEQFSTWQNQKYQKELNLDKKRAERLT 218

Query: 200 LASKIRTLTTSFQLVSRELELTRPLAEKGIVPEVELLKLQRVVNDIQGELASLRLLRPKV 259
+ ++I ++ L+ L K + + +L+ + + EL + ++
Sbjct: 219 VLARINRYENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQI 278

Query: 260 KSTMDEAILKRRESVLIYAADSRAQLNEMQTKLSRMNEAQVGAQDKVSKAEIVSPVNGTV 319
+S + A + + ++ + +L + + + +++ + I +PV+ V
Sbjct: 279 ESEILSAKEEYQLVTQLFKNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKV 338

Query: 320 KTIHINTLGGVVQPGVDIIEIVPSEDKLLIETKIIPKDIAFLHPGLPAVVKVTAYDFTRY 379
+ + ++T GGVV ++ IVP +D L + + KDI F++ G A++KV A+ +TRY
Sbjct: 339 QQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRY 398

Query: 380 GGLNGVVEHISADTTQDEEGNSFYIVKVRTEFSSLTKDDGTQMPIIPGMLTSVDVITGQR 439
G L G V++I+ D +D+ + V + E + L+ +P+ GM + ++ TG R
Sbjct: 399 GYLVGKVKNINLDAIEDQRLGLVFNVIISIEENCLS-TGNKNIPLSSGMAVTAEIKTGMR 457

Query: 440 SVLEYILNPILRAKDTALRER 460
SV+ Y+L+P+ + +LRER
Sbjct: 458 SVISYLLSPLEESVTESLRER 478


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0368CABNDNGRPT671e-12 NodO calcium binding signature.
		>CABNDNGRPT#NodO calcium binding signature.

Length = 479

Score = 66.9 bits (163), Expect = 1e-12
Identities = 45/197 (22%), Positives = 68/197 (34%), Gaps = 17/197 (8%)

Query: 5201 GDDAVNAGEGNDIIFGDLVSFDGIDGQGYSALQAFVAQETSQQATDVTVQDIHDFISNNT 5260
D A + + + + G D +S + + D+ N +
Sbjct: 278 DRDFYTATDSSKALIFSVWDAGGTDTFDFSGYS----NNQRINLNEGSFSDVGGLKGNVS 333

Query: 5261 HLFGANNAE----DGADTLEGGEGNDILFGQGGNDTLIGGLDNDTMIGGLGEDTFKWTVD 5316
G G D L G ++IL G GND L GG DT+ GG G DTF +
Sbjct: 334 IAHGVTIENAIGGSGNDILVGNSADNILQGGAGNDVLYGGAGADTLYGGAGRDTFVYGSG 393

Query: 5317 SVDGTDTTDHITDFNLAEDKLDLSDILQGDTVHELAQH---------LSFTDENGSTSIN 5367
D I DF DK+DLS + + L + N T++
Sbjct: 394 QDSTVAAYDWIADFQKGIDKIDLSAFRNEGQLSFVQDQFTGKGQEVMLQWDAANSITNLW 453

Query: 5368 IDTDGNGSFDQHIVLDG 5384
+ G+ S D + + G
Sbjct: 454 LHEAGHSSVDFLVRIVG 470


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0369CABNDNGRPT803e-17 NodO calcium binding signature.
		>CABNDNGRPT#NodO calcium binding signature.

Length = 479

Score = 80.4 bits (198), Expect = 3e-17
Identities = 44/184 (23%), Positives = 71/184 (38%), Gaps = 17/184 (9%)

Query: 1822 FVEAVFTHEQIADDSITVVGTDNINNLIFGSTNTDSLTGANLDDRIFGREDNDILIGLSG 1881
F A + + + GTD + + + +L + D + G + N +
Sbjct: 281 FYTATDSSKALIFSVWDAGGTDTFDFSGYSNNQRINLNEGSFSD-VGGLKGNVSIAHGVT 339

Query: 1882 NDELIGGSGDDNIQGGEDNDFVIGGIGDDLLDGGVGRDYLSGGQGNDSLDGGELNGSDDG 1941
+ IGGSG+D + G ++ + GG G+D+L GG G D L GG G D+ G
Sbjct: 340 IENAIGGSGNDILVGNSADNILQGGAGNDVLYGGAGADTLYGGAGRDTFVYG-------- 391

Query: 1942 ERDFFVWESDTADNSTDTVFNFNPDIDVLDLSDLLIGEESGNLEDFLFFSFSGGNTTITV 2001
D+ + D + +F ID +DLS E F+ G +
Sbjct: 392 ------SGQDSTVAAYDWIADFQKGIDKIDLSAF--RNEGQLSFVQDQFTGKGQEVMLQW 443

Query: 2002 DADG 2005
DA
Sbjct: 444 DAAN 447



Score = 62.7 bits (152), Expect = 8e-12
Identities = 29/159 (18%), Positives = 46/159 (28%), Gaps = 43/159 (27%)

Query: 1833 ADDSITVVGTDNINNLIFGSTNTDSLTGANLDDRIFGREDNDILIGLSGNDELIGGSGDD 1892
++ + + + + G S+ + G NDIL+G S ++ L GG+G+D
Sbjct: 309 YSNNQRINLNEGSFSDVGGLKGNVSIAHGVTIENAIGGSGNDILVGNSADNILQGGAGND 368

Query: 1893 NIQGGEDNDFVIGGIGDDLLDGGVG-----------RDYLSGGQGNDSLDGGELNG---- 1937
+ GG D + GG G D G G D+ G D
Sbjct: 369 VLYGGAGADTLYGGAGRDTFVYGSGQDSTVAAYDWIADFQKGIDKIDLSAFRNEGQLSFV 428

Query: 1938 ----------------------------SDDGERDFFVW 1948
+ DF V
Sbjct: 429 QDQFTGKGQEVMLQWDAANSITNLWLHEAGHSSVDFLVR 467



Score = 38.4 bits (89), Expect = 3e-04
Identities = 22/116 (18%), Positives = 30/116 (25%), Gaps = 14/116 (12%)

Query: 1833 ADDSITVVGTDNINNLIFGSTN---TDSLTGANLDDRIFGREDNDILIGLSGNDELIGGS 1889
A + ++ T GA + D I + L G N G
Sbjct: 214 AVYAEDSYQFSIMSYWGENETGADYNGHYGGAPMIDDIAAIQR---LYG--ANMTTRTGD 268

Query: 1890 GDDNIQGGEDNDFVIGGIGDDLL------DGGVGRDYLSGGQGNDSLDGGELNGSD 1939
D DF L GG SG N ++ E + SD
Sbjct: 269 SVYGFNSNTDRDFYTATDSSKALIFSVWDAGGTDTFDFSGYSNNQRINLNEGSFSD 324


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0371RTXTOXIND310.008 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 31.0 bits (70), Expect = 0.008
Identities = 14/79 (17%), Positives = 28/79 (35%), Gaps = 5/79 (6%)

Query: 83 GYYFYQQLQAQQAETAELQQTLEQKLQTVLVEPNQRIASLEQQ----QNQFKSSVDLTLA 138
+ Q+ + E L ++ L + I S +++ FK+ + L
Sbjct: 247 QAIAKHAVLEQENKYVEAVNELRV-YKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLR 305

Query: 139 QTLDQQTQLEERVSIIAQR 157
QT D L ++ +R
Sbjct: 306 QTTDNIGLLTLELAKNEER 324


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0375MALTOSEBP290.003 Maltose binding protein signature.
		>MALTOSEBP#Maltose binding protein signature.

Length = 396

Score = 28.9 bits (64), Expect = 0.003
Identities = 19/62 (30%), Positives = 29/62 (46%), Gaps = 6/62 (9%)

Query: 44 QLEFDGASKIVINKQEPLHEIWLATQFGGFHFSYVDGKW------MDERNGHEFMPFLVE 97
+L+ G S ++ N QEP L GG+ F Y +GK+ +D + FLV+
Sbjct: 164 ELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVD 223

Query: 98 SI 99
I
Sbjct: 224 LI 225


64Spea_0589Spea_0595N        Y        YPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_0589221-1.633794porin
Spea_0590011-0.933549porin
Spea_05910140.261808UBA/THIF-type NAD/FAD-binding protein
Spea_0592015-0.009125hypothetical protein
Spea_05930150.715750hypothetical protein
Spea_0594-1140.987948*peptidase S9 prolyl oligopeptidase
Spea_05950181.944506peptidase M50
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0589ECOLNEIPORIN573e-11 E.coli/Neisseria porin superfamily signature.
		>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature.

Length = 331

Score = 56.7 bits (137), Expect = 3e-11
Identities = 71/359 (19%), Positives = 127/359 (35%), Gaps = 43/359 (11%)

Query: 1 MKKTLISASVASVLTLASFGALADGPGFYGRLD----LSATHSDTGATTQNGKEGAILEN 56
MKK+LI+ ++A++ A YG + S + + GA + + G + +
Sbjct: 1 MKKSLIALTLAALPVAAMADV-----TLYGTIKAGVETSRSVAHNGAQAASVETGTGIVD 55

Query: 57 NFSHLGVKGSENIADGYDIVYQMEFGVDNTSNSNKTFTTRNTFLGLKTNAGTVLVGRNDH 116
S +G KG E++ +G ++Q+E + + ++ + R +F+GLK G + VGR +
Sbjct: 56 LGSKIGFKGQEDLGNGLKAIWQVEQKA-SIAGTDSGWGNRQSFIGLKGGFGKLRVGRLNS 114

Query: 117 VFKQT------EGGADVFGNTNADIDRLVAGQDRVGDGIWYYSPKIAGLVTLNATYLMEG 170
V K T + +D G +A + + Y SP+ AGL + Y +
Sbjct: 115 VLKDTGDINPWDSKSDYLGVNK------IAEPEARLISVRYDSPEFAGLSG-SVQYALND 167

Query: 171 NYTDEANKTSYDQ--QYALSATIGDKKLKAQNYYVAAAYNTIKGIDAYRGVAQVKLGDF- 227
N N SY Y + ++ I+ +R V+
Sbjct: 168 N-AGRHNSESYHAGFNYKNGGFFVQYGGAYKRHHQVQENVNIEKYQIHRLVSGYDNDALY 226

Query: 228 -KVAGIFQNTESQTTDQEGNSYF-VNVVYNLNGVNLKAEYGKDEGGFGKYYKNITGGYEE 285
VA Q+ + + NS V N+ Y + G +
Sbjct: 227 ASVAVQQQDAKLVEENYSHNSQTEVAATLAYRFGNVTPRVS---------YAHGFKGSFD 277

Query: 286 GVTSDINVQVITVGADYKISKSTMVYGHYAMYEGDHKVGTATKDLEDDNVFTVGVRYNF 344
+ + + VGA+Y SK T + VG+R+ F
Sbjct: 278 ATNYNNDYDQVVVGAEYDFSKRTSALVSAGWLQEGKGESKFV-----STAGGVGLRHKF 331


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0590ECOLNEIPORIN596e-12 E.coli/Neisseria porin superfamily signature.
		>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature.

Length = 331

Score = 59.0 bits (143), Expect = 6e-12
Identities = 72/365 (19%), Positives = 127/365 (34%), Gaps = 45/365 (12%)

Query: 1 MKKTVLSATIISALAATSFTALADGPSFYGRADLAITNSDM----GIATQNQKSGTIIEN 56
MKK++++ T+ + A + YG + S G + ++GT I +
Sbjct: 1 MKKSLIALTLAALPVAAMADV-----TLYGTIKAGVETSRSVAHNGAQAASVETGTGIVD 55

Query: 57 NFSWLGVKGTEAINSDLEVVYQMEFGVSNFDNSNNTFAARNTFLGLKSATAGTILVGRND 116
S +G KG E + + L+ ++Q+E S +++ + R +F+GLK G + VGR +
Sbjct: 56 LGSKIGFKGQEDLGNGLKAIWQVEQKASI-AGTDSGWGNRQSFIGLK-GGFGKLRVGRLN 113

Query: 117 TVFK------ASEGGFDIFGNTNSDIDLLAAGQSRSADGFSYYSPKIADLVTLNATYLMD 170
+V K + D G ++ +A ++R Y SP+ A L + Y ++
Sbjct: 114 SVLKDTGDINPWDSKSDYLG-----VNKIAEPEARLI-SVRYDSPEFAGLSG-SVQYALN 166

Query: 171 DNYDQVNASGEEVYTDNMYALSATVGDKGLKAQNYYVSAAYNDGIDNVKAYRGVAQVKLG 230
DN + N+ Y + G Q ++ +NV +
Sbjct: 167 DNAGRHNSES--------YHAGFNYKNGGFFVQYGGAYKRHHQVQENVNIEKYQIHR--- 215

Query: 231 QVILGGFYQNSEHVDSKYSNLEGDTYFVNAAYVMGDLKLKAMYGSDDSGLGKYVSRYVGD 290
L Y N S + ++ A + VS Y
Sbjct: 216 ---LVSGYDNDALYASVAVQQQDAKLVEENYSHNSQTEVAATLAYRFGNVTPRVS-YA-H 270

Query: 291 TNGATLETVSDVDL-QQFSVGADYRLSKNTLVYGHYTKYDGDMKLSGFTHDLSDDIFTVG 349
+ + + + Q VGA+Y SK T S F VG
Sbjct: 271 GFKGSFDATNYNNDYDQVVVGAEYDFSKRTSALVSAGWLQEGKGESKFV----STAGGVG 326

Query: 350 MRFDF 354
+R F
Sbjct: 327 LRHKF 331


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0591BONTOXILYSIN290.032 Bontoxilysin signature.
		>BONTOXILYSIN#Bontoxilysin signature.

Length = 1196

Score = 28.7 bits (64), Expect = 0.032
Identities = 9/40 (22%), Positives = 19/40 (47%), Gaps = 1/40 (2%)

Query: 98 VNEVEDFITPENLSEYFQGKKQGGNIDYVVDCIDSVKAKT 137
+N V++F+ ++ F I Y+ I+++ KT
Sbjct: 741 MNRVDNFLNKASIC-VFVEDIYPKFISYMEKYINNINIKT 779


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0595SECFTRNLCASE290.039 Bacterial translocase SecF protein signature.
		>SECFTRNLCASE#Bacterial translocase SecF protein signature.

Length = 333

Score = 28.7 bits (64), Expect = 0.039
Identities = 20/68 (29%), Positives = 30/68 (44%), Gaps = 3/68 (4%)

Query: 106 KDIERQTPTTPIPEKRQFSVVGLASLGFKLLKSAKVIKVLLAGASVAAYSWL-FSFQFAL 164
K T P + F VG + +L+ +A V +L A + Y W+ F +QFAL
Sbjct: 123 KVETALTAVDPALKITSFESVG-PKVSGELVWTA-VWSLLAATVVIMFYIWVRFEWQFAL 180

Query: 165 ALIACLVF 172
+ LV
Sbjct: 181 GAVVALVH 188


65Spea_0664Spea_0670N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_0664-2233.065340sulfate adenylyltransferase subunit 1
Spea_0665-1233.011483TrkA domain-containing protein
Spea_0666-2192.768535adenylylsulfate kinase
Spea_0667-2173.092147N-acetyltransferase GCN5
Spea_0668-2173.313669hypothetical protein
Spea_0669-2162.908957major facilitator transporter
Spea_0670-2152.950354hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0664TCRTETOQM752e-16 Tetracycline resistance protein TetO/TetQ/TetM family ...
		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

signature.
Length = 639

Score = 74.5 bits (183), Expect = 2e-16
Identities = 52/150 (34%), Positives = 70/150 (46%), Gaps = 17/150 (11%)

Query: 41 VDDGKSTLIGRLLHDSAQIYEDQLASLKSDSAKLGTTGEEVDLALLVDGLQAEREQGITI 100
VD GK+TL LL++S I E S GTT D ER++GITI
Sbjct: 12 VDAGKTTLTESLLYNSGAITE-------LGSVDKGTT--------RTDNTLLERQRGITI 56

Query: 101 DVAYRYFSSDKRKFIIADTPGHEQYTRNMATGASTCDLAVLLVDARYGVQTQTRRHAFIA 160
F + K I DTPGH + + S D A+LL+ A+ GVQ QTR
Sbjct: 57 QTGITSFQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHAL 116

Query: 161 SQLGIRHFVVAVNKMDLLGFD-EKVFNDIR 189
++GI + +NK+D G D V+ DI+
Sbjct: 117 RKMGIPT-IFFINKIDQNGIDLSTVYQDIK 145


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0667SACTRNSFRASE458e-09 Streptothricin acetyltransferase signature.
		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

Length = 173

Score = 45.3 bits (107), Expect = 8e-09
Identities = 25/95 (26%), Positives = 43/95 (45%), Gaps = 6/95 (6%)

Query: 40 ERLQNGDATVFISYSCENNPVGFVLNYHTFSSVSLGKIIILNDLFVTESHRKQGVANSLI 99
++ F+ Y ENN +G + ++ +L + D+ V + +RK+GV +L+
Sbjct: 58 SYVEEEGKAAFLYYL-ENNCIGRIKIRSNWNGYAL-----IEDIAVAKDYRKKGVGTALL 111

Query: 100 DCAIDLAKRTGSVRVDLGTAKDNLKAQALYEKIGF 134
AI+ AK + L T N+ A Y K F
Sbjct: 112 HKAIEWAKENHFCGLMLETQDINISACHFYAKHHF 146


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0669TCRTETA362e-04 Tetracycline resistance protein signature.
		>TCRTETA#Tetracycline resistance protein signature.

Length = 399

Score = 36.0 bits (83), Expect = 2e-04
Identities = 34/142 (23%), Positives = 51/142 (35%), Gaps = 12/142 (8%)

Query: 245 VVNLMFAPAIGRFIGRIGERNALTIEYLGLIAVFVSYALVEHAEFAAALY---VIDHLLF 301
++ AP +G R G R L + L V YA++ A F LY ++ +
Sbjct: 54 LMQFACAPVLGALSDRFGRRPVLLV---SLAGAAVDYAIMATAPFLWVLYIGRIVAGITG 110

Query: 302 AMAIAVKTYFQKIADPKDIAAT---MSVSFTINHIAAVIIPALLGLLWLSSPEIVFYIGA 358
A Y I D + A MS F +A P L GL+ SP F+ A
Sbjct: 111 ATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAG---PVLGGLMGGFSPHAPFFAAA 167

Query: 359 GFAACSLLLAINVPRHPQRGDE 380
+ L + +G+
Sbjct: 168 ALNGLNFLTGCFLLPESHKGER 189


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_067056KDTSANTIGN300.022 Rickettsia 56kDa type-specific antigen protein sign...
		>56KDTSANTIGN#Rickettsia 56kDa type-specific antigen protein

signature.
Length = 533

Score = 29.9 bits (67), Expect = 0.022
Identities = 16/44 (36%), Positives = 22/44 (50%), Gaps = 8/44 (18%)

Query: 47 ALKSQLQ---QLAQQQKQQQLQSQQKEAEQQQALQVASEAKSSA 87
A +Q+ + Q +QQQ Q Q QQQA A EA ++A
Sbjct: 325 AFVNQIHLNFVMPPQAQQQQGQGQ-----QQQAQATAQEAVAAA 363


66Spea_0844Spea_0849N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_0844015-1.175616extracellular solute-binding protein
Spea_0845-114-0.369815binding-protein-dependent transport system inner
Spea_0846014-1.112445ABC transporter-like protein
Spea_0847020-1.239285Dyp-type peroxidase family protein
Spea_0848127-1.037333cupin
Spea_0849129-0.971787arginine repressor
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0844adhesinmafb330.002 Neisseria meningitidis: adhesin MafB signature.
		>adhesinmafb#Neisseria meningitidis: adhesin MafB signature.

Length = 467

Score = 32.7 bits (74), Expect = 0.002
Identities = 14/43 (32%), Positives = 20/43 (46%)

Query: 117 YALTMRVRNIYSSKDRLGKLDINYEDLADPKYKGKICTRSGKH 159
AL+ R +Y + LDI+YEDL K G +G+
Sbjct: 348 LALSDSARQLYQNAKYREALDIHYEDLIRRKTDGSSKFINGRE 390


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0846PF05272300.012 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 30.4 bits (68), Expect = 0.012
Identities = 11/31 (35%), Positives = 14/31 (45%)

Query: 34 LLGPSGCGKTTLLRAIAGLQAISHGSITIND 64
L G G GK+TL+ + GL S I
Sbjct: 601 LEGTGGIGKSTLINTLVGLDFFSDTHFDIGT 631


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0847AEROLYSIN300.009 Aerolysin signature.
		>AEROLYSIN#Aerolysin signature.

Length = 493

Score = 30.4 bits (68), Expect = 0.009
Identities = 20/66 (30%), Positives = 30/66 (45%), Gaps = 17/66 (25%)

Query: 30 ESVESDMRPCV--------------ANVAQYIFEL-ADQYSDSAFNGFVAIGANYWDTLY 74
S+ +RP V A+++ Y +E AD D +GF+ G N W T +
Sbjct: 298 TSLSQSVRPTVPARSKIPVKIELYKADIS-YPYEFKADVSYDLTLSGFLRWGGNAWYT-H 355

Query: 75 PDARPS 80
PD RP+
Sbjct: 356 PDNRPN 361


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0849ARGREPRESSOR1486e-49 Bacterial arginine repressor signature.
		>ARGREPRESSOR#Bacterial arginine repressor signature.

Length = 149

Score = 148 bits (376), Expect = 6e-49
Identities = 40/141 (28%), Positives = 70/141 (49%), Gaps = 5/141 (3%)

Query: 15 KSILKEERFGSQSEIVNALQAEGFSNINQSKVSRMLSKFGAVRTRNAKQEMVYCLPAELG 74
+ I+ +Q E+V+ L+ +G+ N+ Q+ VSR + + V+ Y LPA+
Sbjct: 11 REIITANEIETQDELVDILKKDGY-NVTQATVSRDIKELHLVKVPTNNGSYKYSLPADQR 69

Query: 75 VPTAGSPLKNLV---LDVDHNQSMIVVRTSPGAAQLIARLLDSIGKPEGILGTIAGDDTI 131
++L+ + +D +IV++T PG AQ I L+D++ E I+GTI GDDTI
Sbjct: 70 FNPLSKLKRSLMDAFVKIDSASHLIVLKTMPGNAQAIGALMDNLDWEE-IMGTICGDDTI 128

Query: 132 FICPSSIHSIEDTLETVKSLF 152
I + + + + L
Sbjct: 129 LIICRTHDDTKVVQKKILELL 149


67Spea_0871Spea_0878N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_0871-1140.993695phosphoribosylglycinamide formyltransferase 2
Spea_08721180.211333hypothetical protein
Spea_0873017-0.155266secretion protein HlyD family protein
Spea_0874117-1.087863ATPase central domain-containing protein
Spea_0875119-1.774707hypothetical protein
Spea_0876017-1.581416hypothetical protein
Spea_0877017-1.553163histidine kinase
Spea_0878015-2.391981two component transcriptional regulator
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0871PF06057310.006 Type IV secretory pathway VirJ component
		>PF06057#Type IV secretory pathway VirJ component

Length = 243

Score = 31.0 bits (70), Expect = 0.006
Identities = 10/28 (35%), Positives = 13/28 (46%), Gaps = 2/28 (7%)

Query: 17 GCGELGKEVAIELQRYGIEVIGVD--RY 42
G L K V LQ+ G V+G +Y
Sbjct: 62 GWATLDKAVGGILQQQGWPVVGWSSLKY 89


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0873RTXTOXIND483e-08 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 48.3 bits (115), Expect = 3e-08
Identities = 36/230 (15%), Positives = 78/230 (33%), Gaps = 25/230 (10%)

Query: 99 FQAIVKQKRAALVAAELEVPQLEAAWETARASVTRATADRDRTKSAFDRYEKGRKRGGVN 158
+ + EL + + A T A + R KS D + + +
Sbjct: 191 IKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSRVEKSRLDDFSSLLHKQAI- 249

Query: 159 SPFTELELDNKRQLYFAS-------------EAQLTAANAEELRVRLAYESNVDG----V 201
+ L+ + + A E+++ +A E V +++ +
Sbjct: 250 -AKHAV-LEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLRQT 307

Query: 202 NTKVAGIQGELEKAQFELEQTVVKAPADGMVTQMALRPGIVAVPMPLRPLLSFIPDEERA 261
+ + EL K + + +V++AP V Q+ + V L+ +P+++
Sbjct: 308 TDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVH-TEGGVVTTAETLMVIVPEDDTL 366

Query: 262 FVGAFWQNSLL-RLKEGDEAEVILDGAPGQ---VFKGRVAKVLPAMAEGE 307
V A QN + + G A + ++ P G+V + E +
Sbjct: 367 EVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNINLDAIEDQ 416



Score = 46.0 bits (109), Expect = 2e-07
Identities = 26/174 (14%), Positives = 61/174 (35%), Gaps = 20/174 (11%)

Query: 66 INPAVRGVVVSVEVEPNTPIKKGDVLFRIDPTPFQAIVKQKRAALVAAELEVPQLEAAWE 125
I P +V + V+ ++KGDVL ++ +A + +++L+ A LE
Sbjct: 99 IKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQ-------- 150

Query: 126 TARASVTRATADRDRTKSAFDRYEKGRKRGGVNSPFTELELDNKRQLYFASEAQLTAANA 185
R + + + ++ E + +E E+ L + Q +
Sbjct: 151 -TRYQILSRSIELNKLPELKLPDEPYFQN------VSEEEVLRLTSLI---KEQFSTWQN 200

Query: 186 EELRVRLAYESNVDGVNTKVAGIQGELEKAQFELEQTVVKAP--ADGMVTQMAL 237
++ + L + T +A I ++ E + + + + A+
Sbjct: 201 QKYQKELNLDKKRAERLTVLARINRYENLSRVEKSRLDDFSSLLHKQAIAKHAV 254


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0877PF06580320.003 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 32.1 bits (73), Expect = 0.003
Identities = 20/122 (16%), Positives = 41/122 (33%), Gaps = 29/122 (23%)

Query: 305 EETIYLIAEPSLVERALQNLITNA------QRFSTDDIKVKISQDTDGIRLSVTDHGEGI 358
I + P ++ +Q L+ N Q I +K ++D + L V + G
Sbjct: 247 NPAIMDVQVPPML---VQTLVENGIKHGIAQLPQGGKILLKGTKDNGTVTLEVENTGSLA 303

Query: 359 LEEDQSKIFEPFYRSSSSKNGNKGHGLGLAIIKRIMDRHH---AEVSLQSRPGFTQFTLF 415
L+ + + G GL ++ + + A++ L + G +
Sbjct: 304 LKNTK-----------------ESTGTGLQNVRERLQMLYGTEAQIKLSEKQGKVNAMVL 346

Query: 416 WP 417
P
Sbjct: 347 IP 348


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0878HTHFIS742e-17 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 74.1 bits (182), Expect = 2e-17
Identities = 29/130 (22%), Positives = 57/130 (43%), Gaps = 4/130 (3%)

Query: 9 RVLLVEDDIRLANLIVDFLKSHGMHVEVERRGDTVLTRLINYKPDIILLDIMLPGMDGLT 68
+L+ +DD + ++ L G V + T+ + D+++ D+++P +
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64

Query: 69 LCEKLPDYFAG-PILLMSALGSNEDQIKGLELGADDYVVKPVDP---ALLVARINNLLRR 124
L ++ P+L+MSA + IK E GA DY+ KP D ++ R +R
Sbjct: 65 LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKR 124

Query: 125 QAKPAQVESH 134
+ + +S
Sbjct: 125 RPSKLEDDSQ 134


68Spea_0908Spea_0924N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_0908-210-0.271409response regulator receiver modulated
Spea_0909-28-0.382035Hpt sensor hybrid histidine kinase
Spea_09100101.573331leucyl aminopeptidase
Spea_0911-1131.621085YjgP/YjgQ family permease
Spea_0912-1121.966159YjgP/YjgQ family permease
Spea_0913-1121.932891RDD domain-containing protein
Spea_0914-2121.668816hypothetical protein
Spea_0915-2122.354983N-acetyltransferase GCN5
Spea_0916-1112.788428carboxypeptidase Taq
Spea_09170122.518390peptidase S8/S53 subtilisin kexin sedolisin
Spea_09180122.261879hypothetical protein
Spea_09190101.973808DEAD/DEAH box helicase
Spea_09200112.048854peptidase M24
Spea_09210141.454907major facilitator transporter
Spea_0922-1130.669721peptidase M24
Spea_0923-2160.397677FKBP-type peptidylprolyl isomerase
Spea_0924-1170.534403OmpA/MotB domain-containing protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0908HTHFIS568e-11 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 56.4 bits (136), Expect = 8e-11
Identities = 13/86 (15%), Positives = 34/86 (39%), Gaps = 5/86 (5%)

Query: 2 KILLIEDHLFQREAMQMQLELITSPKISLIRTAASGVEALQIMADFKPDILLCDLKMPEM 61
IL+ +D R + L +R ++ + +A D+++ D+ MP+
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYD----VRITSNAATLWRWIAAGDGDLVVTDVVMPDE 60

Query: 62 DGITFLSHISEL-MFTGSIIITSASN 86
+ L I + +++++ +
Sbjct: 61 NAFDLLPRIKKARPDLPVLVMSAQNT 86


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0909HTHFIS643e-12 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 63.7 bits (155), Expect = 3e-12
Identities = 32/129 (24%), Positives = 55/129 (42%), Gaps = 15/129 (11%)

Query: 1067 ILVAEDHPINQDVIQMQLNKLGYFSDIFDDGQQALTAYKQNKYNLVLTDCHMPELDGYGL 1126
ILVA+D + V+ L++ GY I + +LV+TD MP+ + + L
Sbjct: 6 ILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFDL 65

Query: 1127 VSAIREHEQQEKLTRLAVIALTA-----NAISSEKARCHQFGFDDYLIKPVTLEQLQRVL 1181
+ I++ L V+ ++A AI + + G DYL KP L +L ++
Sbjct: 66 LPRIKKARP-----DLPVLVMSAQNTFMTAIKASEK-----GAYDYLPKPFDLTELIGII 115

Query: 1182 SEHLVMTQS 1190
L +
Sbjct: 116 GRALAEPKR 124


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0914VACCYTOTOXIN250.039 Helicobacter pylori vacuolating cytotoxin signature.
		>VACCYTOTOXIN#Helicobacter pylori vacuolating cytotoxin signature.

Length = 1291

Score = 25.0 bits (54), Expect = 0.039
Identities = 11/43 (25%), Positives = 21/43 (48%), Gaps = 8/43 (18%)

Query: 7 YKFKNQAKEINFAYDKFHDMYEAVAAAEGIDLTQYLMMEQQVA 49
++ N++ +I D A + A+G DL Q L+++ A
Sbjct: 888 FELANRSNDI--------DTLYANSGAQGRDLLQTLLIDSHDA 922


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0915SACTRNSFRASE310.001 Streptothricin acetyltransferase signature.
		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

Length = 173

Score = 30.7 bits (69), Expect = 0.001
Identities = 18/69 (26%), Positives = 29/69 (42%), Gaps = 5/69 (7%)

Query: 81 DTLYLHDIALSSLSQGKGAGRQVLTALMNLALSKGYPSISLVAVQG----AHHYWAKQGF 136
+ DIA++ + KG G +L + A + + L Q A H++AK F
Sbjct: 88 GYALIEDIAVAKDYRKKGVGTALLHKAIEWAKENHFCGLML-ETQDINISACHFYAKHHF 146

Query: 137 EIKKIDKDL 145
I +D L
Sbjct: 147 IIGAVDTML 155


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0917SUBTILISIN1352e-37 Subtilisin serine protease family (S8) signature.
		>SUBTILISIN#Subtilisin serine protease family (S8) signature.

Length = 326

Score = 135 bits (341), Expect = 2e-37
Identities = 71/210 (33%), Positives = 97/210 (46%), Gaps = 24/210 (11%)

Query: 124 AGMKVCVIDSGLDRSNQDFVWNNISG----DNDSGTGDWDQNGGPHGTHVAGTIGAADNN 179
G+KV V+D+G D + D I G D+D G + ++ HGTHVAGTI A +N
Sbjct: 41 RGVKVAVLDTGCDADHPDLKARIIGGRNFTDDDEGDPEIFKDYNGHGTHVAGTIAATENE 100

Query: 180 VGVVGMAPGVDMHIIKVFNADGWGYSSDLAHAADLCSNAGANIISMSLGGGGSNSTESNA 239
GVVG+AP D+ IIKV N G G + +IISMSLGG A
Sbjct: 101 NGVVGVAPEADLLIIKVLNKQGSGQYDWIIQGIYYAIEQKVDIISMSLGGPEDVPELHEA 160

Query: 240 FQSFSDAGGLVLAAAGNDGNSVRS-----YPAGYPSVMMIGANDATDAIADFSQFPSCTT 294
+ + LV+ AAGN+G+ YP Y V+ +GA + ++FS +
Sbjct: 161 VKKAVASQILVMCAAGNEGDGDDRTDELGYPGCYNEVISVGAINFDRHASEFSNSNN--- 217

Query: 295 GRGKKQRTDLSICVEIAAGGVDTLSTYPAG 324
V++ A G D LST P G
Sbjct: 218 ------------EVDLVAPGEDILSTVPGG 235



Score = 46.4 bits (110), Expect = 2e-07
Identities = 20/73 (27%), Positives = 25/73 (34%), Gaps = 5/73 (6%)

Query: 442 TSDYGFMSGTSMATPAVSGIAARVWSN-----HNQCTGEEIRAALNASARDSGASGHDVY 496
Y SGTSMATP V+G A + T E+ A L G S
Sbjct: 234 GGKYATFSGTSMATPHVAGALALIKQLANASFERDLTEPELYAQLIKRTIPLGNSPKMEG 293

Query: 497 FGHGIVDAAAADA 509
G + A +
Sbjct: 294 NGLLYLTAVEELS 306


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0919SECA290.037 SecA protein signature.
		>SECA#SecA protein signature.

Length = 901

Score = 29.1 bits (65), Expect = 0.037
Identities = 35/173 (20%), Positives = 64/173 (36%), Gaps = 42/173 (24%)

Query: 220 SQVVYPVEQRRKRELLSELIGK-KNWQQVLVFTATRDAADKLEKELNLDGIPTAVVHGEK 278
+VY E + + ++ ++ + Q VLV T + + ++ + EL GI V++
Sbjct: 424 PDLVYMTEAEKIQAIIEDIKERTAKGQPVLVGTISIEKSELVSNELTKAGIKHNVLN--- 480

Query: 279 AQGSRRRALREFKEGKM-RVLVATEVAARGLDIQ---------------GLEYVVNYDLP 322
A+ A + G V +AT +A RG DI E +
Sbjct: 481 AKFHANEAAIVAQAGYPAAVTIATNMAGRGTDIVLGGSWQAEVAALENPTAEQIEKIKAD 540

Query: 323 FLAED---------YV--------HRI-----GRTGRAGKSGVAISFVSREEE 353
+ ++ RI GR+GR G +G + ++S E+
Sbjct: 541 WQVRHDAVLEAGGLHIIGTERHESRRIDNQLRGRSGRQGDAGSSRFYLSMEDA 593


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0921TCRTETB362e-04 Tetracycline resistance protein TetB signature.
		>TCRTETB#Tetracycline resistance protein TetB signature.

Length = 458

Score = 36.0 bits (83), Expect = 2e-04
Identities = 26/140 (18%), Positives = 54/140 (38%), Gaps = 1/140 (0%)

Query: 243 SLADTKWVIQSHIIAMYLPSLFSGALVARLGVSKMMLLGLLAYLVTIITAVIGRDLLNYW 302
A T WV + ++ + + G L +LG+ +++L G++ + +G +
Sbjct: 47 PPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGIIINCFGSVIGFVGHSFFSLL 106

Query: 303 -AALVLLGIGWNFLFVAGTALLPRCYAKTERYKVQSFNDTFIFGAQAMASLSAGWVIHLL 361
A + G G ++ R K R K + + + + G + H +
Sbjct: 107 IMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGLIGSIVAMGEGVGPAIGGMIAHYI 166

Query: 362 GWNVLLLSCLPLIVAQVLLI 381
W+ LLL + I+ L+
Sbjct: 167 HWSYLLLIPMITIITVPFLM 186


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0923INFPOTNTIATR1417e-45 Macrophage infectivity potentiator signature.
		>INFPOTNTIATR#Macrophage infectivity potentiator signature.

Length = 233

Score = 141 bits (356), Expect = 7e-45
Identities = 70/132 (53%), Positives = 90/132 (68%), Gaps = 2/132 (1%)

Query: 25 KAAKENIALGNAFLAENKLKDGVTTTASGLQYQVLEPGTGTVHPKASDTVTVHYHGTLID 84
K A+EN A G+AFL+ NK K G+ SGLQY++++ GTG P SDTVTV Y GTLID
Sbjct: 99 KKAEENKAKGDAFLSANKSKPGIVVLPSGLQYKIIDAGTGA-KPGKSDTVTVEYTGTLID 157

Query: 85 GTVFDSSVERGEPIAFPLNRVIKGWTEGVQLMVVGEKARFFIPSELAYGNRS-AGKISGG 143
GTVFDS+ + G+P F +++VI GWTE +QLM G F+P++LAYG RS G I
Sbjct: 158 GTVFDSTEKAGKPATFQVSQVIPGWTEALQLMPAGSTWEVFVPADLAYGPRSVGGPIGPN 217

Query: 144 STLIFDVELISI 155
TLIF + LIS+
Sbjct: 218 ETLIFKIHLISV 229


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_0924OMPADOMAIN2013e-64 OMPA domain signature.
		>OMPADOMAIN#OMPA domain signature.

Length = 346

Score = 201 bits (513), Expect = 3e-64
Identities = 105/345 (30%), Positives = 158/345 (45%), Gaps = 36/345 (10%)

Query: 24 SVYAAEADSSEPANEFAPYFYLGAKAGQMHYQNAC-ESWSVSCDGNYVGFGGFAGYQAWQ 82
+V A + A +Y GAK G Y + + + N +G G F GYQ
Sbjct: 9 AVALAGFATVAQAAPKDNTWYTGAKLGWSQYHDTGFINNNGPTHENQLGAGAFGGYQVNP 68

Query: 83 YLGFETAYLDLGEAVSGYSESAVNNTYVGSMKGWELSAVTRFGLSEDFELFAKAGSFYWD 142
Y+GFE Y LG Y S N Y +G +L+A + +++D +++ + G W
Sbjct: 69 YVGFEMGYDWLGRM--PYKGSVENGAY--KAQGVQLTAKLGYPITDDLDIYTRLGGMVWR 124

Query: 143 GDNQG-PYSRNSDSGWAPMLGAGLAYQISPSWVARLEYQYIDKLGS--DLIGGSNGHLTT 199
D + Y +N D+G +P+ G+ Y I+P RLEYQ+ + +G + + + +
Sbjct: 125 ADTKSNVYGKNHDTGVSPVFAGGVEYAITPEIATRLEYQWTNNIGDAHTIGTRPDNGMLS 184

Query: 200 LGISYRFGQKKPASVSQVKEKPITLPEKVIPVTAKPVVFPALTVTS--LFDFDSSELTNS 257
LG+SYRFGQ + A P+ P P A V T+ S LF+F+ + L
Sbjct: 185 LGVSYRFGQGEAA--------PVVAPA---PAPAPEVQTKHFTLKSDVLFNFNKATLKPE 233

Query: 258 -----DSLTAVIERLNQVPTAIANIKGYTDSTGAAAYNQALSERRAQAVADDLIAAGIKP 312
D L + + L+ + GYTD G+ AYNQ LSERRAQ+V D LI+ GI
Sbjct: 234 GQAALDQLYSQLSNLD-PKDGSVVVLGYTDRIGSDAYNQGLSERRAQSVVDYLISKGIPA 292

Query: 313 EQIEVHGFGEQFPVMKNDTSEHRH---------ENRRVLIHIQST 348
++I G GE PV N + +RRV I ++
Sbjct: 293 DKISARGMGESNPVTGNTCDNVKQRAALIDCLAPDRRVEIEVKGI 337


69Spea_1087Spea_1100N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_1087226-3.265758type IV pilus modification protein PilV
Spea_1088226-3.537136type IV pilus assembly protein PilW
Spea_1089324-3.446289type IV pilus assembly protein PilX
Spea_1090323-3.609176type IV pilin biogenesis protein
Spea_1091024-4.385602methylation site containing protein
Spea_1092019-2.284270hypothetical protein
Spea_1093-116-1.608106type IV pilus biogenesis protein
Spea_1094-114-1.499535type IV pilus biogenesis protein
Spea_1095-111-0.753772nitrogen regulatory protein P-II
Spea_1096-111-0.331617LacI family transcriptional regulator
Spea_1097-1100.280776TonB-dependent receptor
Spea_10980100.322989tryptophan halogenase
Spea_10991110.173411SapC family protein
Spea_11002110.440550beta-N-acetylhexosaminidase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1087PilS_PF08805280.027 PilS N terminal
		>PilS_PF08805#PilS N terminal

Length = 185

Score = 27.6 bits (61), Expect = 0.027
Identities = 14/71 (19%), Positives = 31/71 (43%), Gaps = 9/71 (12%)

Query: 5 EKGLSLIEVLVALVILTVGLIGVFNLHVISKRGSFESFQQTQAAYLANDIISRIKLNRSQ 64
+KG +L+EVL+ + ++ V + L+ + Q + +I+ +K + Q
Sbjct: 25 DKGATLMEVLLVVGVIVVLAASAYKLY----SMVQSNIQSSNEQNNVLTVIANMKSLKFQ 80

Query: 65 LTSYAGTYSGT 75
G Y+ +
Sbjct: 81 -----GRYTDS 86


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1091BCTERIALGSPG457e-09 Bacterial general secretion pathway protein G signa...
		>BCTERIALGSPG#Bacterial general secretion pathway protein G

signature.
Length = 145

Score = 44.9 bits (106), Expect = 7e-09
Identities = 19/59 (32%), Positives = 34/59 (57%)

Query: 5 KGFTLIELMITVAIIGILASIAYPSYIDYILQAGRSDAKVILLEAANKQEQLYLDSRTY 63
+GFTL+E+M+ + IIG+LAS+ P+ + +A + A ++ N + LD+ Y
Sbjct: 8 RGFTLLEIMVVIVIIGVLASLVVPNLMGNKEKADKQKAVSDIVALENALDMYKLDNHHY 66


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1093BCTERIALGSPH388e-06 Bacterial general secretion pathway protein H signa...
		>BCTERIALGSPH#Bacterial general secretion pathway protein H

signature.
Length = 170

Score = 37.6 bits (87), Expect = 8e-06
Identities = 16/77 (20%), Positives = 33/77 (42%), Gaps = 6/77 (7%)

Query: 7 RISAFTLVELMVTLAVATILITVAAPSFNSFYENSRSDSAIRNIQQSLQLARSQAVSYGS 66
R FTL+E+M+ L + + + +F + ++S + + R + L+ + + + G
Sbjct: 2 RQRGFTLLEMMLILLLMGVSAGMVLLAFPASRDDSAAQTLAR-FEAQLRFVQQRGLQTGQ 60

Query: 67 TVTVCPLRDGTCGTDWQ 83
V D WQ
Sbjct: 61 FFGVSVHPDR-----WQ 72


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1094BCTERIALGSPG362e-05 Bacterial general secretion pathway protein G signa...
		>BCTERIALGSPG#Bacterial general secretion pathway protein G

signature.
Length = 145

Score = 36.0 bits (83), Expect = 2e-05
Identities = 21/76 (27%), Positives = 31/76 (40%), Gaps = 4/76 (5%)

Query: 4 KTTGFTLIELMVTLVVATILIVIAVPSFTIFYAQARADSNIRKIQQSIQLARNHAVSYGS 63
K GFTL+E+MV +V+ +L + VP+ + + +AD I N Y
Sbjct: 6 KQRGFTLLEIMVVIVIIGVLASLVVPN--LMGNKEKADKQKAVSD--IVALENALDMYKL 61

Query: 64 RVTVCPITAQGCSENW 79
P T QG
Sbjct: 62 DNHHYPTTNQGLESLV 77


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1097ACRIFLAVINRP350.002 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 34.8 bits (80), Expect = 0.002
Identities = 28/146 (19%), Positives = 55/146 (37%), Gaps = 29/146 (19%)

Query: 67 SVVDAVTAEDIGKFPDGDVGESLGRIPGVAVNRQFGQGQQVSIRGASSQLTRTLLNGHSV 126
S T +DI + +V ++L R+ GV + FG + I
Sbjct: 144 SDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGAQYAMRI----------------- 186

Query: 127 ASTGWYDQQAIDRSFNYSLLPPEMVGAIEVYKSSQADIPEGGIGGT-VIVKTRKPLDLDA 185
W D + Y L P +++ + K I G +GGT + + + A
Sbjct: 187 ----WLDADLL---NKYKLTPVDVINQL---KVQNDQIAAGQLGGTPALPGQQLNASIIA 236

Query: 186 NSVFISAKGDYGTISEEVDPELSGLY 211
+ F + + ++G ++ V+ + S +
Sbjct: 237 QTRFKNPE-EFGKVTLRVNSDGSVVR 261


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1100DHBDHDRGNASE300.028 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase sig...
		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

signature.
Length = 261

Score = 30.4 bits (68), Expect = 0.028
Identities = 17/69 (24%), Positives = 29/69 (42%), Gaps = 6/69 (8%)

Query: 238 DTPNSPKLAENAILPTPTKVALKSDAKSVSLK-SGLKLTLNGVSPGAVDAALQR---LAQ 293
+ P+ + A +K A K + L+ + + N VSPG+ + +Q +
Sbjct: 145 NPAGVPRTSMAAY--ASSKAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADE 202

Query: 294 LGVEQTDKG 302
G EQ KG
Sbjct: 203 NGAEQVIKG 211


70Spea_1150Spea_1156N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_1150-1162.336597RND family efflux transporter MFP subunit
Spea_1151-2172.583007hydrophobe/amphiphile efflux-1 (HAE1) family
Spea_1152-3161.464010iron-containing alcohol dehydrogenase
Spea_1153-1181.053502hypothetical protein
Spea_1154-1171.628871hypothetical protein
Spea_1155-1151.568032acriflavin resistance protein
Spea_11560161.244602RND family efflux transporter MFP subunit
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1150RTXTOXIND320.003 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 32.1 bits (73), Expect = 0.003
Identities = 22/124 (17%), Positives = 44/124 (35%), Gaps = 13/124 (10%)

Query: 97 STYKAELAQHQAVLKQAVASRDVAVMNWERGRRLLPDGMISAQDMDELTSRKLTTA-AGV 155
EL +++ L+Q + A + +L+ Q KL +
Sbjct: 262 VEAVNELRVYKSQLEQIESEILSA----KEEYQLV------TQLFKNEILDKLRQTTDNI 311

Query: 156 VQAEAAVDAAELQLSYTKVYAPISGRISHSKV-SIGDIITPQSEMANIV-QLQPMWVNFQ 213
+ E + + + AP+S ++ KV + G ++T + IV + + V
Sbjct: 312 GLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTAL 371

Query: 214 VAEK 217
V K
Sbjct: 372 VQNK 375



Score = 29.0 bits (65), Expect = 0.034
Identities = 16/89 (17%), Positives = 32/89 (35%), Gaps = 12/89 (13%)

Query: 81 EGDDIAAGDLLFEIDPSTYKAELAQHQAVLKQAVASRDVAVMNWERGRRLLPDGMISAQD 140
EG+ + GD+L ++ +A+ + Q+ L QA + R + L + +
Sbjct: 114 EGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQ-------TRYQILS-----RSIE 161

Query: 141 MDELTSRKLTTAAGVVQAEAAVDAAELQL 169
+++L KL L
Sbjct: 162 LNKLPELKLPDEPYFQNVSEEEVLRLTSL 190


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1151ACRIFLAVINRP9940.0 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 994 bits (2572), Expect = 0.0
Identities = 439/1034 (42%), Positives = 643/1034 (62%), Gaps = 12/1034 (1%)

Query: 2 ISEFFINRPKFAFVISTVLTLVGLISIPVLSVSEFPEIAPPQVSVSTSYSGASADIVKDT 61
++ FFI RP FA+V++ +L + G ++I L V+++P IAPP VSVS +Y GA A V+DT
Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60

Query: 62 IAQPLEAEVNGVEGMLYMESKSANDGSYSLNVTFEVGTDADMAQVKVQNRVQQAMPRLPE 121
+ Q +E +NG++ ++YM S S + GS ++ +TF+ GTD D+AQV+VQN++Q A P LP+
Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120

Query: 122 EVKRQGVKVEKQSPNMLMVVNLVSPNETFDSLFITNYAGLNVKDALARQYGVSKVQVIGA 181
EV++QG+ VEK S + LMV VS N I++Y NVKD L+R GV VQ+ GA
Sbjct: 121 EVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGA 180

Query: 182 LDYAMRIWLDPDQMASLGVTATDVIGALQEQNIQVAAGRIGAAPVDPEQQFQYTLQTKGR 241
YAMRIWLD D + +T DVI L+ QN Q+AAG++G P P QQ ++ + R
Sbjct: 181 -QYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTR 239

Query: 242 LKDPQEFYDVMIRANNDGSKVVVGDVARVELGSQTYDAQGKLNNKPSAIISIYQSPDANA 301
K+P+EF V +R N+DGS V + DVARVELG + Y+ ++N KP+A + I + ANA
Sbjct: 240 FKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANA 299

Query: 302 LEVGKAIKAEMEKLSERFPNDLEYEVLYDTTEFVETSIKEVVQTLFISIALVVFVVFIFL 361
L+ KAIKA++ +L FP ++ YDTT FV+ SI EVV+TLF +I LV V+++FL
Sbjct: 300 LDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFL 359

Query: 362 QDVRSTLVPAIAIPVSLIGTFAFLLAFGMSINTVSLFALILAIGIVVDDAIVVVENVTRL 421
Q++R+TL+P IA+PV L+GTFA L AFG SINT+++F ++LAIG++VDDAIVVVENV R+
Sbjct: 360 QNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERV 419

Query: 422 MQDEGLSPKEATSKAMKEVTGPIIATTLVLLAVFAPTAVMPGITGQMYAQFSVTICISVL 481
M ++ L PKEAT K+M ++ G ++ +VL AVF P A G TG +Y QFS+TI ++
Sbjct: 420 MMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMA 479

Query: 482 ISSINALTLSPALCASVLRAPKLHE----KGFHAAFNKHFERVTGKYMKLVSSLTRKLVL 537
+S + AL L+PALCA++L+ GF FN F+ Y V +
Sbjct: 480 LSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGR 539

Query: 538 VGIVYGCLILLTGGIAKILPSGFVPMEDKKAFMVDIQLPDGASLNRTEDVMRDLVELTLA 597
++Y ++ + LPS F+P ED+ F+ IQLP GA+ RT+ V+ + + L
Sbjct: 540 YLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYLK 599

Query: 598 --EPGVENVIHASGFSILTGSVSSNGGLMIVTLSTWDERESADMMESAIVAKLQAKYAAN 655
+ VE+V +GFS + N G+ V+L W+ER + A++ + + +
Sbjct: 600 NEKANVESVFTVNGFS--FSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKI 657

Query: 656 PAVKAMAFSLPPIPGVGSVGGFEFVLQDTQGRTPQELASVMRALIMKANEQP-EIAMAFS 714
+ F++P I +G+ GF+F L D G L L+ A + P +
Sbjct: 658 RDGFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRP 717

Query: 715 NFRADVPQMFVDVDRDKAKALGVSLNEIFATMQTMLGSMYVNDFNRFGKVFRVILQAETE 774
N D Q ++VD++KA+ALGVSL++I T+ T LG YVNDF G+V ++ +QA+ +
Sbjct: 718 NGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADAK 777

Query: 775 YRNSDKDISRFYVRSKTGEMVPLSTLVTVTPILGPDVMNNYNMFSSTTINGFPAAGFSSG 834
+R +D+ + YVRS GEMVP S T + G + YN S I G A G SSG
Sbjct: 778 FRMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAPGTSSG 837

Query: 835 DAITAMERAANESLPSGYTYEWTGQTYQEIKAGNLAPLIFGLALVFTYLFLVAQYESWTI 894
DA+ ME A++ LP+G Y+WTG +YQE +GN AP + ++ V +L L A YESW+I
Sbjct: 838 DAMALMENLASK-LPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYESWSI 896

Query: 895 PFAVILAVPIAVLGAFLNILLVGSDLNLYAQIGLVLLIGLACKNAILIVEFAKQLRE-EG 953
P +V+L VP+ ++G L L ++Y +GL+ IGL+ KNAILIVEFAK L E EG
Sbjct: 897 PVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAKDLMEKEG 956

Query: 954 KSILEAGETAARLRFRAVLMTAFSFLLGVLPLVIATGAGAGSRRALGYSVFGGMLAATVV 1013
K ++EA A R+R R +LMT+ +F+LGVLPL I+ GAG+G++ A+G V GGM++AT++
Sbjct: 957 KGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLL 1016

Query: 1014 GTLLVPVFYVIMQK 1027
VPVF+V++++
Sbjct: 1017 AIFFVPVFFVVIRR 1030



Score = 86.0 bits (213), Expect = 5e-19
Identities = 103/516 (19%), Positives = 190/516 (36%), Gaps = 60/516 (11%)

Query: 545 LILLTGGIA-KILPSGFVPMEDKKAFMVDIQLPDGASLNRTEDVMRDLVELTLAEPGVEN 603
++++ G +A LP P A V P GA +D + ++E + G++N
Sbjct: 18 ILMMAGALAILQLPVAQYPTIAPPAVSVSANYP-GADAQTVQDTVTQVIEQNMN--GIDN 74

Query: 604 VIHASGFSILTGSVSSNGGLMIVTLSTWDERESADMMESAIVAKLQAKYAANPAVKAMAF 663
+++ S S S + G + +TL T+ D+ + + KLQ P
Sbjct: 75 LMYMS-------STSDSAGSVTITL-TFQSGTDPDIAQVQVQNKLQLATPLLPQ----EV 122

Query: 664 SLPPIPGVGSVGGFEFVL---QDTQGRTPQEL----ASVMRALIMKANEQPEIAMAFSNF 716
I S + V D G T ++ AS ++ + + N ++ + + +
Sbjct: 123 QQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGAQY 182

Query: 717 RADVPQMFVDVDRDKAKALGVSLNEIF-----ATMQTMLGSMYVNDFNRFGKVFRVILQA 771
M + +D D ++ ++ Q G G+ + A
Sbjct: 183 -----AMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQ-LGGTPALPGQQLNASIIA 236

Query: 772 ETEYRNSDKDISRFYVR-SKTGEMVPLSTLVTVTPILGPDVMNNYNMFSSTTINGFPAAG 830
+T ++ + ++ + +R + G +V L + V LG + NYN ING PAAG
Sbjct: 237 QTRFK-NPEEFGKVTLRVNSDGSVVRLKDVARVE--LGGE---NYN--VIARINGKPAAG 288

Query: 831 FS-----------SGDAITAMERAANESLPSGYTYEWTGQTYQEIKAGNLA---PLIFGL 876
+ AI A P G + T ++ L +
Sbjct: 289 LGIKLATGANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAI 348

Query: 877 ALVFTYLFLVAQYESWTIPFAVILAVPIAVLGAFLNILLVGSDLNLYAQIGLVLLIGLAC 936
LVF ++L ++ +AVP+ +LG F + G +N G+VL IGL
Sbjct: 349 MLVFLVMYLF--LQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLV 406

Query: 937 KNAILIVE-FAKQLREEGKSILEAGETAARLRFRAVLMTAFSFLLGVLPLVIATGAGAGS 995
+AI++VE + + E+ EA E + A++ A +P+ G+
Sbjct: 407 DDAIVVVENVERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAI 466

Query: 996 RRALGYSVFGGMLAATVVGTLLVPVFYVIMQKMREK 1031
R ++ M + +V +L P + K
Sbjct: 467 YRQFSITIVSAMALSVLVALILTPALCATLLKPVSA 502


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1155ACRIFLAVINRP7740.0 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 774 bits (1999), Expect = 0.0
Identities = 305/1032 (29%), Positives = 516/1032 (50%), Gaps = 28/1032 (2%)

Query: 3 LSDVSVKRPVVAIVLSLLLCVFGAVSFTKLAVREMPDVESPVVTVMTTYEGASATIMESQ 62
+++ ++RP+ A VL+++L + GA++ +L V + P + P V+V Y GA A ++
Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60

Query: 63 ITTALESELTGISGVDQIESVT-RNGMSRITVTFLLGWDLTEGVSDVRDAVARAQRRLPD 121
+T +E + GI + + S + G IT+TF G D V++ + A LP
Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120

Query: 122 EAKDPIVSKDNGSGEPAVYVNLSSSVMDRTQ--LTDYAQRVLEDRFSLISGVSSVDISGG 179
E + +S + S + S TQ ++DY ++D S ++GV V + G
Sbjct: 121 EVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGA 180

Query: 180 LYKVMYVQLNPELMAGRNITASDIVSVLNRENVETPGGEVRNDTTV------MAVRTARL 233
Y + + L+ +L+ +T D+++ L +N + G++ + ++
Sbjct: 181 QYAMR-IWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTR 239

Query: 234 YQTPDDFNYLVLRTAADGSQVYLKDVANVFIGAENENSTFKSDGVVNISLGIVPQSDANP 293
++ P++F + LR +DGS V LKDVA V +G EN N + +G LGI + AN
Sbjct: 240 FKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANA 299

Query: 294 LEVAQDVHKEVDQIQKFLPEGTKLIVDYDSTVFIDRSIDEVFSTLAVTALLVILVLYIFI 353
L+ A+ + ++ ++Q F P+G K++ YD+T F+ SI EV TL +LV LV+Y+F+
Sbjct: 300 LDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFL 359

Query: 354 GQARATLIPAVTVPVSLISAFIAANVFGYSINLLTLMALILSIGLVVDDAIVVVENIFHH 413
RATLIP + VPV L+ F FGYSIN LT+ ++L+IGL+VDDAIVVVEN+
Sbjct: 360 QNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERV 419

Query: 414 I-EKGEPPILAAYNGTREVGFAVMATTAVLVMVFLPISFMEGMVGLLFTEFSVMLAVSVL 472
+ E PP A ++ A++ VL VF+P++F G G ++ +FS+ + ++
Sbjct: 420 MMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMA 479

Query: 473 FSSLIALTLTPVLGSKILKANVK-----PNRFNVWVESIFTRLENFYRKMVTKAVTLRLA 527
S L+AL LTP L + +LK F W + F N Y V K +
Sbjct: 480 LSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGR 539

Query: 528 APLVIIACILGSGWLMQQVPAQLAPQEDRGVIFAFIKGAEGTSYNRMAANMEIVEDKLMP 587
L+ + G L ++P+ P+ED+GV I+ G + R ++ V D +
Sbjct: 540 YLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYLK 599

Query: 588 LLGQGVVKSFSIQAPAFGGRAGDQTGFVIIQLEDWNERTVNAQQALGIVAKA---LKGIP 644
V F++ +F G+ G + L+ W ER + A ++ +A L I
Sbjct: 600 NEKANVESVFTVNGFSFSGQ-AQNAGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKIR 658

Query: 645 DVMVRP--LLPGFRGGSSEPVQFVL---GGSDYQELFKWAQMLEEEALYSPI-LDSPEID 698
D V P + G++ F L G + L + L A P L S +
Sbjct: 659 DGFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRPN 718

Query: 699 YKETSPELVVTVDKERAAQLGISVAEVSETLEIMLGGRSETTFVERGEEYDVYLRGDENS 758
E + + + VD+E+A LG+S++++++T+ LGG F++RG +Y++ D
Sbjct: 719 GLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADAKF 778

Query: 759 FNNVADLSQIYMRSAKGELITLDTITHIEEVASALKLSHNNKQKSITLKANLAEGYTLGE 818
D+ ++Y+RSA GE++ T V + +L N S+ ++ A G + G+
Sbjct: 779 RMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAPGTSSGD 838

Query: 819 ALDFLDQKAIEMLPSDISVAYTGESKDFKENQSSIFIVFGLALLVAYLVLAAQFESFINP 878
A+ + + LP+ I +TG S + + + + ++ +V +L LAA +ES+ P
Sbjct: 839 AMALM-ENLASKLPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYESWSIP 897

Query: 879 LVVMFTVPMGVFGGFLGLYLTGQGLNIYSQIGMIMLIGMVTKNGILIVEFANQLRDR-GL 937
+ VM VP+G+ G L L Q ++Y +G++ IG+ KN ILIVEFA L ++ G
Sbjct: 898 VSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAKDLMEKEGK 957

Query: 938 EIEQAIIDASVRRLRPILMTAFTTLIGAIPLILSTGAGAESRISVGTVVFFGMAFATFVT 997
+ +A + A RLRPILMT+ ++G +PL +S GAG+ ++ +VG V GM AT +
Sbjct: 958 GVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLLA 1017

Query: 998 LLVIPAMYRLIS 1009
+ +P + +I
Sbjct: 1018 IFFVPVFFVVIR 1029


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1156RTXTOXIND384e-05 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 38.3 bits (89), Expect = 4e-05
Identities = 35/189 (18%), Positives = 74/189 (39%), Gaps = 20/189 (10%)

Query: 100 AKAQAALAESAAYLAD---EKRKLKEFLKLIDQNAITKTEIDAQKASVDMA--TARLAAA 154
+A L + L E KE +L+ Q + ++ + ++ T LA
Sbjct: 262 VEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLRQTTDNIGLLTLELAKN 321

Query: 155 QADLDYHYLSAPFSGT-AGLIDFSQGKMVSAGTELLTL-DDLSSMRLDLQIPENYLSQLS 212
+ + AP S L ++G +V+ L+ + + ++ + + + ++
Sbjct: 322 EERQQASVIRAPVSVKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFIN 381

Query: 213 VGMSVTASSRAWPQKQF---IGKV--IAIDSRVNQDT-LNLRVRVQFD-------NPSHR 259
VG + A+P ++ +GKV I +D+ +Q L V + + N +
Sbjct: 382 VGQNAIIKVEAFPYTRYGYLVGKVKNINLDAIEDQRLGLVFNVIISIEENCLSTGNKNIP 441

Query: 260 LKPGMMMSA 268
L GM ++A
Sbjct: 442 LSSGMAVTA 450



Score = 36.7 bits (85), Expect = 1e-04
Identities = 32/183 (17%), Positives = 64/183 (34%), Gaps = 13/183 (7%)

Query: 69 ISPQIAGKIKSIQVSTEQEIAQGQILIQLDDAKAQAALAESAAYLADEKRKLKEFLKLID 128
I P +K I V + + +G +L++L A+A ++ + L +L++ I
Sbjct: 99 IKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQA--RLEQTRYQIL 156

Query: 129 QNAITKTEIDAQKASVDMATARLAAAQADLDYHYLSAPFSGTAGLIDFSQGKMVSAGTEL 188
+I ++ K + ++ + + FS + + E
Sbjct: 157 SRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAER 216

Query: 189 LTLDDLSSMRLDLQIPENYLSQLSVGMSVTASSRAWPQKQFIGK--VIAIDSRVNQDTLN 246
LT+ L Y + V S + KQ I K V+ +++ +
Sbjct: 217 LTV---------LARINRYENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNE 267

Query: 247 LRV 249
LRV
Sbjct: 268 LRV 270


71Spea_1322Spea_1326N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_1322-1213.118777methyl-accepting chemotaxis sensory transducer
Spea_1323-2213.025366hypothetical protein
Spea_1324-3192.984303acriflavin resistance protein
Spea_1325-2151.551105RND family efflux transporter MFP subunit
Spea_1326-111-0.015958TetR family transcriptional regulator
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1322RTXTOXIND320.010 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 31.7 bits (72), Expect = 0.010
Identities = 20/185 (10%), Positives = 55/185 (29%), Gaps = 5/185 (2%)

Query: 473 LQSLSNQLTDSHNSVEIVNKESQAISKITEVINSIAEQTNLLALNAAIEAARAGEQGRGF 532
LQ+ Q S I + + E + +L L + I+ + Q +
Sbjct: 144 LQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQ-- 201

Query: 533 AVVADEVRTLAQRTQTSIAEISQTITQLQSQVKFTTEQMNQSNELGDVSAAQGNEAIAQL 592
+ + + + I + ++ + +++ + L A + + Q
Sbjct: 202 ---KYQKELNLDKKRAERLTVLARINRYENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQE 258

Query: 593 LEINTSIAELAATSTSIASATEQQSAVAEEITRNLHQITELARDGEQRAGESVDSAESLA 652
+ ++ EL + + + + EE D ++ +++
Sbjct: 259 NKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLRQTTDNIGLLTLEL 318

Query: 653 TIANE 657
E
Sbjct: 319 AKNEE 323


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1324ACRIFLAVINRP375e-115 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 375 bits (965), Expect = e-115
Identities = 202/1045 (19%), Positives = 432/1045 (41%), Gaps = 67/1045 (6%)

Query: 10 RLISLVIALLIV-AGFGAISSLPRMEDPEITNRFASVITHYPGASAERVEALVTEVLESE 68
+ + V+A++++ AG AI LP + P I SV +YPGA A+ V+ VT+V+E
Sbjct: 9 PIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDTVTQVIEQN 68

Query: 69 LRRLEELKLVQSTS-RPGISVIQLELKDDVIETAPVWSR--ARDLIADAKGLLPQSAQNT 125
+ ++ L + STS G I L + T P ++ ++ + A LLPQ Q
Sbjct: 69 MNGIDNLMYMSSTSDSAGSVTITLTFQSG---TDPDIAQVQVQNKLQLATPLLPQEVQQQ 125

Query: 126 TLDDQLGYANTAILGVVWRGSGVVRTDMLNRYAKE-LQSRLRLLSGTDFVNLYGQPAEEI 184
+ + ++ ++ + D ++ Y ++ L L+G V L+G +
Sbjct: 126 GISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGAQ-YAM 184

Query: 185 LVQLDGNKVNQLQLSAKTIAQILQNADAKVSAGEINN------QQFRALVEVSGELDSLA 238
+ LD + +N+ +L+ + L+ + +++AG++ QQ A + +
Sbjct: 185 RIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRFKNPE 244

Query: 239 RISQVPLKVTASGQIIRLADIATISRQPKEPANSIALIDQEQGVMVAARMLSNTRVDLWL 298
+V L+V + G ++RL D+A + E N IA I+ + + ++ +
Sbjct: 245 EFGKVTLRVNSDGSVVRLKDVARV-ELGGENYNVIARINGKPAAGLGIKLATGANALDTA 303

Query: 299 EKVRTAVEELQTSIPANIEIQWLFDQEGYTTERLSDLVGSLLLG-FLIILAVLMLTLGLR 357
+ ++ + ELQ P +++ + +D + + ++V +L L+ L + + +R
Sbjct: 304 KAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQNMR 363

Query: 358 NALIVALSLPLTALFTLACMKYIGLPIHQMSVTGLVVALGIMVDNAIVIVDAISQRRQK- 416
LI +++P+ L T A + G I+ +++ G+V+A+G++VD+AIV+V+ + + +
Sbjct: 364 ATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVMMED 423

Query: 417 GTDRLTAVKETLQHLWLPLAGSTITTMLAFAPIVLMPGAAGEFVGGIAISVMFALLGSFI 476
A ++++ + L G + F P+ G+ G +I+++ A+ S +
Sbjct: 424 KLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALSVL 483

Query: 477 ISHTIIAGLAGRFGVDGKSQHWYQHGINLPWLSDAFRQTLTLA-------LARPLLAAIV 529
++ + L ++H G W + F ++ L ++
Sbjct: 484 VALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGRYLLI 543

Query: 530 IGVLPVMGFIAAGKMTEQFFPPSDRDMFQIEVYLAPHASIANTREQVSQIDADL--RATA 587
++ + ++ F P D+ +F + L A+ T++ + Q+ A
Sbjct: 544 YALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYLKNEKA 603

Query: 588 GITRIDWVVGGNAPSFYYNLLQRQQGASHYAQAMVKVSDFD-------TANKLIPQLQKT 640
+ + V G + A + A V + ++ +A +I + +
Sbjct: 604 NVESVFTVNGFSFSG----------QAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKME 653

Query: 641 LD-----IRYPQAQIIVRKLEQGPPFNAPVEVRIFGPNLDQLKLLGEQVRKLLSET-ADV 694
L P + +L F+ + + G D L Q+ + ++ A +
Sbjct: 654 LGKIRDGFVIPFNMPAIVELGTATGFDFELIDQ-AGLGHDALTQARNQLLGMAAQHPASL 712

Query: 695 IHTRATLSAGAPKVWLQIDEDASLMSGLSLTDIAKQVEMATTGINGGSILEQTESLPVRV 754
+ R + L++D++ + G+SL+DI + + A G +++ + V
Sbjct: 713 VSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYV 772

Query: 755 RLNDSTREEQTKLAEITLVSSQGKGIPLSAISSSEIEVSRGAIPRRDGQRVNTIEAYITS 814
+ + R + ++ + S+ G+ +P SA ++S + R +G I
Sbjct: 773 QADAKFRMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPS----MEIQG 828

Query: 815 GVLPQTVVDSVSAKLSDIA--LPSGYRLELGGESAKRNEAVGNLMSNLVLVVTLLLATVV 872
P T A + ++A LP+G + G S + + + + + ++ +
Sbjct: 829 EAAPGTSSGDAMALMENLASKLPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLA 888

Query: 873 LSFNSFRLTAIILFSAMQSAGLGLLAVYSFGYPFGFTVIIGLLGLMGLAINAAIVILAEL 932
+ S+ + ++ LLA F ++GLL +GL+ AI+I+
Sbjct: 889 ALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFA 948

Query: 933 EEVPKARAGDKQTIVDLVTSCG----RHIGSTTITTIGGFLPLII---AGGGFWPPFAIA 985
++ + + +V+ R I T++ I G LPL I AG G I
Sbjct: 949 KD---LMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIG 1005

Query: 986 IAGGTLLTTLLSLIWVPTMYHLLMR 1010
+ GG + TLL++ +VP + ++ R
Sbjct: 1006 VMGGMVSATLLAIFFVPVFFVVIRR 1030


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1325RTXTOXIND393e-05 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 38.7 bits (90), Expect = 3e-05
Identities = 18/121 (14%), Positives = 38/121 (31%), Gaps = 21/121 (17%)

Query: 76 GKIKALGVDSGDKVKQGQLLAKLDTRLLMAEKNELTASLAQNKADL-------------- 121
+K + V G+ V++G +L KL A+ + +SL Q + +
Sbjct: 105 SIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNK 164

Query: 122 -----DLAKATLDRSLGLQKQGYVS--EQQLDELKGQLSSLQAAKTRLNASLLANQLKIE 174
+ + S ++Q + Q + + A L +I
Sbjct: 165 LPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARIN 224

Query: 175 K 175
+
Sbjct: 225 R 225


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1326HTHTETR763e-19 TetR bacterial regulatory protein HTH signature.
		>HTHTETR#TetR bacterial regulatory protein HTH signature.

Length = 215

Score = 75.8 bits (186), Expect = 3e-19
Identities = 29/138 (21%), Positives = 48/138 (34%), Gaps = 5/138 (3%)

Query: 9 RSEQKRGQILQAAKELFCEHGFPNTSMDEVAKLAGVSKQTVYSHFGCKDDLFVA--SIES 66
+++ R IL A LF + G +TS+ E+AK AGV++ +Y HF K DLF +
Sbjct: 8 EAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSE 67

Query: 67 KCLVHGVNQEVFADPKAPEQSLMLFAKHFGEVITSPEAVTVFKACVSQADTHP---EISE 123
+ + P P L H E + E + + + +
Sbjct: 68 SNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQ 127

Query: 124 LFYSAGPQHILGLLRDYL 141
+ L
Sbjct: 128 QAQRNLCLESYDRIEQTL 145


72Spea_1338Spea_1398N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_1338016-0.309655response regulator receiver modulated CheW
Spea_1339-1151.099183CheR-type MCP methyltransferase
Spea_1340-1151.211185flagellar basal body rod protein FlgB
Spea_1341-1151.406516flagellar basal body rod protein FlgC
Spea_13420171.873938flagellar basal body rod modification protein
Spea_13430161.703492flagellar hook protein FlgE
Spea_13440121.734854flagellar basal body rod protein FlgF
Spea_1345-1121.219744flagellar basal body rod protein FlgG
Spea_13460111.361427flagellar basal body L-ring protein
Spea_13470111.275875flagellar basal body P-ring protein
Spea_1348190.706693flagellar rod assembly protein/muramidase FlgJ
Spea_13491100.415492flagellar hook-associated protein FlgK
Spea_1350114-0.401652flagellar hook-associated protein FlgL
Spea_1351120-0.743405flagellin domain-containing protein
Spea_1352116-1.278240flagellin domain-containing protein
Spea_1353013-1.310583flagellar protein FlaG protein
Spea_1354012-0.273799flagellar hook-associated 2 domain-containing
Spea_1355-112-0.241831hypothetical protein
Spea_1356-1110.647467flagellar protein FliS
Spea_1357-1100.855893sigma-54 dependent trancsriptional regulator
Spea_1358-1111.685286PAS/PAC sensor signal transduction histidine
Spea_1359-1112.864457Fis family two component sigma54 specific
Spea_1360-1133.004278flagellar hook-basal body complex subunit FliE
Spea_13612112.951209flagellar MS-ring protein
Spea_13622152.955495flagellar motor switch protein G
Spea_13631143.028097flagellar assembly protein FliH
Spea_13640142.777203flagellum-specific ATP synthase
Spea_13651161.431887flagellar export protein FliJ
Spea_13661130.605451flagellar hook-length control protein
Spea_1367115-0.018359flagellar basal body-associated protein FliL
Spea_13682170.401269flagellar motor switch protein FliM
Spea_13692190.955743flagellar motor switch protein
Spea_13701192.221072flagellar biosynthesis protein FliO
Spea_13711161.531677flagellar biosynthesis protein FliP
Spea_13720161.844293flagellar biosynthetic protein FliQ
Spea_13730151.886524flagellar biosynthesis protein FliR
Spea_13740151.647364flagellar biosynthesis protein FlhB
Spea_1375-1140.825773flagellar biosynthesis protein FlhA
Spea_1376015-0.311585flagellar biosynthesis regulator FlhF
Spea_13770140.336319cobyrinic acid ac-diamide synthase
Spea_13780150.014269flagellar biosynthesis sigma factor
Spea_1379-114-0.282864response regulator receiver protein
Spea_1380015-0.263157chemotaxis phosphatase CheZ
Spea_1381-115-0.043771signal transduction histidine kinase CheA
Spea_1382018-0.430343chemotaxis-specific methylesterase
Spea_1383119-1.059083hypothetical protein
Spea_1384116-2.086533cobyrinic acid ac-diamide synthase
Spea_1385015-2.075812CheW protein
Spea_1386-113-2.740746CheW protein
Spea_1387-114-2.325816hypothetical protein
Spea_1388-113-2.391729FlhB domain-containing protein
Spea_1389-115-2.287881hypothetical protein
Spea_1390-217-1.970740VacJ family lipoprotein
Spea_1391-218-2.106463response regulator receiver protein
Spea_1393-221-2.396754amino acid/peptide transporter
Spea_1394-220-3.540366transcriptional acivator RfaH
Spea_1395-222-4.249523polysaccharide export protein
Spea_1396031-7.463373hypothetical protein
Spea_1397134-9.066545lipopolysaccharide biosynthesis protein
Spea_1398238-10.576740dTDP-glucose-4,6-dehydratase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1338HTHFIS662e-14 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 66.4 bits (162), Expect = 2e-14
Identities = 22/128 (17%), Positives = 52/128 (40%), Gaps = 12/128 (9%)

Query: 180 HIMVIDDSSVARKQIIRALTSLDLQIDTAKDGKEALEKLRAIAVGCEDVSTEIPLIISDI 239
I+V DD + R + +AL+ + + + A +++D+
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDL---------VVTDV 55

Query: 240 EMPEMDGYTLTAEIRDDPKLKNIKVVLHTSLSGVFNQAMVQKVGANDFIAK-FNPDELAA 298
MP+ + + L I+ ++ V++ ++ + + GA D++ K F+ EL
Sbjct: 56 VMPDENAFDLLPRIKK--ARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIG 113

Query: 299 AVNKHLSL 306
+ + L+
Sbjct: 114 IIGRALAE 121


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1341FLGHOOKAP1342e-04 Flagellar hook-associated protein signature.
		>FLGHOOKAP1#Flagellar hook-associated protein signature.

Length = 546

Score = 33.8 bits (77), Expect = 2e-04
Identities = 11/38 (28%), Positives = 18/38 (47%)

Query: 99 NVNVMEEMANMISASRSYQMNVQVTEAAKSMLQQTLRI 136
VN+ EE N+ + Y N QV + A ++ + I
Sbjct: 508 GVNLDEEYGNLQRFQQYYLANAQVLQTANAIFDALINI 545



Score = 26.5 bits (58), Expect = 0.047
Identities = 10/25 (40%), Positives = 17/25 (68%)

Query: 8 NVAGSGMSAQSVRLNTTASNIANAD 32
N A SG++A LNT ++NI++ +
Sbjct: 5 NNAMSGLNAAQAALNTASNNISSYN 29


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1343FLGHOOKAP1415e-06 Flagellar hook-associated protein signature.
		>FLGHOOKAP1#Flagellar hook-associated protein signature.

Length = 546

Score = 41.5 bits (97), Expect = 5e-06
Identities = 28/94 (29%), Positives = 41/94 (43%), Gaps = 7/94 (7%)

Query: 2 SFNIALSGISSAQKDLNTTANNIANVNTTGFKESRAEFADVYASSIFANSKTTVGGGVAT 61
N A+SG+++AQ LNT +NNI++ N G+ A S++ A VG GV
Sbjct: 3 LINNAMSGLNAAQAALNTASNNISSYNVAGYTRQTTIMAQA-NSTLGAGG--WVGNGVYV 59

Query: 62 SQVAQQFHQGSMQFTNNSLDMAINGGGFFVTSSE 95
S V +++ F N L A E
Sbjct: 60 SGVQREYD----AFITNQLRAAQTQSSGLTARYE 89



Score = 38.0 bits (88), Expect = 6e-05
Identities = 12/49 (24%), Positives = 24/49 (48%)

Query: 405 SIRSSALEQSNVDLTTELVDLISAQRNFQANSRTLEVNNTLQQTVLQIR 453
+ + S V+L E +L Q+ + AN++ L+ N + ++ IR
Sbjct: 498 QLSNQQQSISGVNLDEEYGNLQRFQQYYLANAQVLQTANAIFDALINIR 546


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1344FLGHOOKAP1290.020 Flagellar hook-associated protein signature.
		>FLGHOOKAP1#Flagellar hook-associated protein signature.

Length = 546

Score = 28.8 bits (64), Expect = 0.020
Identities = 10/34 (29%), Positives = 18/34 (52%)

Query: 4 LLYVAMSGAKQNMNSLAVSANNLANANTDGFKSS 37
L+ AMSG +L ++NN+++ N G+
Sbjct: 3 LINNAMSGLNAAQAALNTASNNISSYNVAGYTRQ 36


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1345FLGHOOKAP1466e-08 Flagellar hook-associated protein signature.
		>FLGHOOKAP1#Flagellar hook-associated protein signature.

Length = 546

Score = 46.5 bits (110), Expect = 6e-08
Identities = 20/119 (16%), Positives = 40/119 (33%), Gaps = 4/119 (3%)

Query: 145 EDATSITVSAEGEVSVKTPGNAENQVVGQLAISDFINPSGLDPMGQNLYMETG---ASGT 201
D I +++E + N + + Q + +L + G A+
Sbjct: 427 TDEAKIAMASEEDAGDSDNRNGQALLDLQSNSKTVGGAKSFNDAYASLVSDIGNKTATLK 486

Query: 202 PIQGTASLDGMGAIRQGALETSNVNVTEELVNLIESQRIYEMNSKVISAVDQMLSYVNQ 260
T + + S VN+ EE NL Q+ Y N++V+ + + +
Sbjct: 487 TSSATQGNV-VTQLSNQQQSISGVNLDEEYGNLQRFQQYYLANAQVLQTANAIFDALIN 544



Score = 35.3 bits (81), Expect = 2e-04
Identities = 8/36 (22%), Positives = 21/36 (58%)

Query: 5 LWISKTGLDAQQTDISVISNNVANASTVGFKKSRAV 40
+ + +GL+A Q ++ SNN+++ + G+ + +
Sbjct: 4 INNAMSGLNAAQAALNTASNNISSYNVAGYTRQTTI 39


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1346FLGLRINGFLGH1422e-44 Flagellar L-ring protein signature.
		>FLGLRINGFLGH#Flagellar L-ring protein signature.

Length = 232

Score = 142 bits (359), Expect = 2e-44
Identities = 72/219 (32%), Positives = 108/219 (49%), Gaps = 15/219 (6%)

Query: 1 MLMAAISGCNSTNGKPIADDPYYAPVYPEAPPTKIAATGSMYQDSQ-----ASSLYSDIK 55
+L+ +++GC P+ A P P A GS++Q +Q L+ D +
Sbjct: 14 LLVLSLTGCAWIPSTPLVQGATSAQPVPGPTP---VANGSIFQSAQPINYGYQPLFEDRR 70

Query: 56 ALKVGDIITVLLMEQTQAKKSANNEISK----GTDLSLDPIYAGGGNVTIGGNPIDLRYK 111
+GD +T++L E A KS++ S+ P Y G G D+
Sbjct: 71 PRNIGDTLTIVLQENVSASKSSSANASRDGKTNFGFDTVPRYLQGLF---GNARADVEAS 127

Query: 112 DSMNTKRESDADQSNSLSGSISANVMQVLNNGNLVIRGEKWISINNGDEFVRITGIVRAQ 171
+ A+ SN+ SG+++ V QVL NGNL + GEK I+IN G EF+R +G+V +
Sbjct: 128 GGNTFNGKGGANASNTFSGTLTVTVDQVLVNGNLHVVGEKQIAINQGTEFIRFSGVVNPR 187

Query: 172 DIRPDNTIDSQRVANARIQYSGTGTFAEVQKVGWLASFF 210
I NT+ S +VA+ARI+Y G G E Q +GWL FF
Sbjct: 188 TISGSNTVPSTQVADARIEYVGNGYINEAQNMGWLQRFF 226


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1347FLGPRINGFLGI383e-134 Flagellar P-ring protein signature.
		>FLGPRINGFLGI#Flagellar P-ring protein signature.

Length = 373

Score = 383 bits (984), Expect = e-134
Identities = 164/367 (44%), Positives = 223/367 (60%), Gaps = 14/367 (3%)

Query: 6 LVLLCAILALSAPVHAQ--RIKDIANVQGVRSNQLIGYGLVVGLPGTGEKTR---YTEQT 60
LV + P A RIKDIA++Q R NQLIGYGLVVGL GTG+ R +TEQ+
Sbjct: 11 LVFSALPFLSTPPAQADTSRIKDIASLQAGRDNQLIGYGLVVGLQGTGDSLRSSPFTEQS 70

Query: 61 FKTMLKNFGINLPDNFRPKIKNIAVVAVSAEMPPFIKPGQTLDVTVSSLGEAKSLRGGML 120
+ ML+N GI + KNIA V V+A +PPF PG +DVTVSSLG+A SLRGG L
Sbjct: 71 MRAMLQNLGITTQGG-QSNAKNIAAVMVTANLPPFASPGSRVDVTVSSLGDATSLRGGNL 129

Query: 121 LQTFLKGVDGNVYAIAQGSMVVSGFSAEGMDGSKVVQNTPTVGRIPNGAIIERTVATPFS 180
+ T L G DG +YA+AQG+++V+GFSA+G D + + Q T R+PNGAIIER + + F
Sbjct: 130 IMTSLSGADGQIYAVAQGALIVNGFSAQG-DAATLTQGVTTSARVPNGAIIERELPSKFK 188

Query: 181 TGDHLTFNLRRADFSTAKRLADSINDL----LGPGMARPLDAASVQVSAPRDVSQRVSFL 236
+L LR DFSTA R+AD +N G +A P D+ + V PR V+ +
Sbjct: 189 DSVNLVLQLRNPDFSTAVRVADVVNAFARARYGDPIAEPRDSQEIAVQKPR-VADLTRLM 247

Query: 237 ATLENIEVEPAAESAKVIVNSRTGTIVVGQNVKLLPAAVTHGGLTVTIAEATQVSQPNAF 296
A +EN+ VE AKV++N RTGTIV+G +V++ AV++G LTV + E+ QV QP F
Sbjct: 248 AEIENLTVETDTP-AKVVINERTGTIVIGADVRISRVAVSYGTLTVQVTESPQVIQPAPF 306

Query: 297 GNGQTVVTTDSTIDVAEEDSRMFMFNPGTTLDELVRAVNLVGAAPSDVLAILEALKMAGA 356
GQT V + I +E S++ + G L LV +N +G ++AIL+ +K AGA
Sbjct: 307 SRGQTAVQPQTDIMAMQEGSKVAIVE-GPDLRTLVAGLNSIGLKADGIIAILQGIKSAGA 365

Query: 357 LHGELII 363
L EL++
Sbjct: 366 LQAELVL 372


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1348FLGFLGJ1992e-63 Flagellar protein FlgJ signature.
		>FLGFLGJ#Flagellar protein FlgJ signature.

Length = 313

Score = 199 bits (506), Expect = 2e-63
Identities = 105/344 (30%), Positives = 173/344 (50%), Gaps = 58/344 (16%)

Query: 7 ASQFLDLGGLDSLRSRAQKDETSALKEVAQQFEGIFVQMLMKSMRDANAVFESDSPMNSQ 66
AS D L+ L+++A +D + ++ VA+Q EG+FVQM++KSMRDA D +S+
Sbjct: 9 ASAAWDAQSLNELKAKAGEDPAANIRPVARQVEGMFVQMMLKSMRDALP---KDGLFSSE 65

Query: 67 YTKFYEQMHDQQMSLNLSGEGMLGLADLMVQQLDPANSPMTPASVLRGDINGGSKAAALT 126
+T+ Y M+DQQ++ ++ LGLA++MV+Q+ P
Sbjct: 66 HTRLYTSMYDQQIAQQMTAGKGLGLAEMMVKQMTPEQ----------------------- 102

Query: 127 MDRPDMLQMPSSRIASPDTITDHVPKNQNSFASNSQASAPQAITSSVQSQTLDSVLSGKI 186
P ++P + + + QA++ VQ
Sbjct: 103 ---------PLPEESTPAAPMKFPLETVVRYQN-------QALSQLVQ------------ 134

Query: 187 LPSAAVNADKSQANFTSQDEFVARLYPHAQKAAQTLGTTPEVLIAQSALETGWGQKMVKG 246
+ N D S S+ F+A+L AQ A+Q G +++AQ+ALE+GWGQ+ ++
Sbjct: 135 -KAVPRNYDDS-LPGDSKA-FLAQLSLPAQLASQQSGVPHHLILAQAALESGWGQRQIRR 191

Query: 247 HQGQQSNNLFNIKADNRWQGEKASVSTLEYEQGIAVKQQANFRVYEDIGQSFNDFVSFVS 306
G+ S NLF +KA W+G ++T EYE G A K +A FRVY ++ +D+V ++
Sbjct: 192 ENGEPSYNLFGVKASGNWKGPVTEITTTEYENGEAKKVKAKFRVYSSYLEALSDYVGLLT 251

Query: 307 NGERYQDAMKQAANPQAFIRSLQEAGYATDPKYADKVIQVMKTI 350
RY A+ AA+ + ++LQ+AGYATDP YA K+ +++ +
Sbjct: 252 RNPRYA-AVTTAASAEQGAQALQDAGYATDPHYARKLTNMIQQM 294


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1349FLGHOOKAP12176e-65 Flagellar hook-associated protein signature.
		>FLGHOOKAP1#Flagellar hook-associated protein signature.

Length = 546

Score = 217 bits (553), Expect = 6e-65
Identities = 117/454 (25%), Positives = 197/454 (43%), Gaps = 19/454 (4%)

Query: 4 DLMNIARTGVLASQSQLAITSNNIANANTAGYNRQVVSQSALDSQRMGNDFYGAGTYVSD 63
L+N A +G+ A+Q+ L SNNI++ N AGY RQ + +S + G G YVS
Sbjct: 2 SLINNAMSGLNAAQAALNTASNNISSYNVAGYTRQTTIMAQANSTLGAGGWVGNGVYVSG 61

Query: 64 VKRVYNDYATRELRIGSTAVSETQTTFGKMSELDQLFSQIGKGVPEGLNNFFASMNALSD 123
V+R Y+ + T +LR T S + +MS++D + S + + +FF S+ L
Sbjct: 62 VQREYDAFITNQLRAAQTQSSGLTARYEQMSKIDNMLSTSTSSLATQMQDFFTSLQTLVS 121

Query: 124 IPGDLGMRGSMLTSANQLADSINQMQGHLDSQMTQTNDQIAAVTTRINEISKELGNINRE 183
D R +++ + L + +L Q Q N I A +IN +K++ ++N +
Sbjct: 122 NAEDPAARQALIGKSEGLVNQFKTTDQYLRDQDKQVNIAIGASVDQINNYAKQIASLNDQ 181

Query: 184 LMKSQGEDM-----QLLDKQDALILELSEYASVNVVPLDSGAKSVMLGGSMMLVSGEVSM 238
+ + G LLD++D L+ EL++ V V D G ++ + LV G +
Sbjct: 182 ISRLTGVGAGASPNNLLDQRDQLVSELNQIVGVEVSVQDGGTYNITMANGYSLVQGSTAR 241

Query: 239 QMGTVQGDPYPNELQITAQSG--NKSMIVDATKLGGQLGALVNYRDETLTPSQMEFGQYA 296
Q+ V P+ + G I + G LG ++ +R + L ++ GQ A
Sbjct: 242 QLAAVPSSADPSRTTVAYVDGTAGNIEIPEKLLNTGSLGGILTFRSQDLDQTRNTLGQLA 301

Query: 297 LGVADAFNQAQAQGFDLNGQVGANIFTDINDPSMQIGRVGALSSNTGTANLSVNIDDVGS 356
L A+AFN GFD NG G + F + V + N G + + D +
Sbjct: 302 LAFAEAFNTQHKAGFDANGDAGEDFFA------IGKPAVLQNTKNKGDVAIGATVTDASA 355

Query: 357 LTGSSYELKF--TAPSTYELKDAASGNITPLTLNGTKLEGADGFSIDIDAGALASGDTFE 414
+ + Y++ F L + +TP +G + G A D+F
Sbjct: 356 VLATDYKISFDNNQWQVTRLASNTTFTVTPDANGKVAFDGLELTFT----GTPAVNDSFT 411

Query: 415 IRPTSGAAASISVEMTDGKGIAAAGTKITADAAN 448
++P S A ++ V +TD IA A + D+ N
Sbjct: 412 LKPVSDAIVNMDVLITDEAKIAMASEEDAGDSDN 445



Score = 93.1 bits (231), Expect = 5e-22
Identities = 40/104 (38%), Positives = 58/104 (55%)

Query: 534 AEGDNTNMVNMAKLNEAKLMNGGKTTLNDVYENTKFDVGSKTKAAEVAMGSADAIYTQAY 593
+ DN N + L GG + ND Y + D+G+KT + + + + TQ
Sbjct: 441 GDSDNRNGQALLDLQSNSKTVGGAKSFNDAYASLVSDIGNKTATLKTSSATQGNVVTQLS 500

Query: 594 TRVQSVSGVNLDEEAANLMRFQQSYQASARIMTTANEIFNTLFS 637
+ QS+SGVNLDEE NL RFQQ Y A+A+++ TAN IF+ L +
Sbjct: 501 NQQQSISGVNLDEEYGNLQRFQQYYLANAQVLQTANAIFDALIN 544


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1350FLAGELLIN613e-12 Flagellin signature.
		>FLAGELLIN#Flagellin signature.

Length = 507

Score = 61.2 bits (148), Expect = 3e-12
Identities = 49/307 (15%), Positives = 104/307 (33%), Gaps = 3/307 (0%)

Query: 1 MRISTAQMFHQTSSNVLKGQSATSQILEQLASGKKVNTAGDDPIAAAGIDNLNQQSALTN 60
I+T + T +N+ K QS+ S +E+L+SG ++N+A DD A +
Sbjct: 2 QVINTNSLSLLTQNNLNKSQSSLSSAIERLSSGLRINSAKDDAAGQAIANRFTSNIKGLT 61

Query: 61 QFLKNIDYASNRLAVSESKIGSAETLIQSMHEGMLRSVNGTLNDADRQAIADEMRSSLEE 120
Q +N + + +E + +Q + E +++ NGT +D+D ++I DE++ LEE
Sbjct: 62 QASRNANDGISIAQTTEGALNEINNNLQRVRELSVQATNGTNSDSDLKSIQDEIQQRLEE 121

Query: 121 LMSIANSKDESGNSLFAGFATDTTPFAFDNSGNVVYSGDSGVRDSIVASGITVGSNIA-- 178
+ ++N +G + + ++ + S+ G V
Sbjct: 122 IDRVSNQTQFNGVKVLSQDNQMKIQVGANDGETITIDLQKIDVKSLGLDGFNVNGPKEAT 181

Query: 179 -GDSIFMNAANAIGDYSVNYSASQTGSFTVESAKVTDASLPVVGDYTFDFVDNGAGGLDL 237
GD D + + + V + + D
Sbjct: 182 VGDLKSSFKNVTGYDTYAVGANKYRVDVNSGAVVTDTTAPTVPDKVYVNAANGQLTTDDA 241

Query: 238 NVTDSSGGVDTIPNFDPSQPVTVDGIELQFKGTPVAGDTFSMSPETQSNIFDTLNSAISL 297
+ T + + ++ D ++ + + N +S
Sbjct: 242 ENNTAVDLFKTTKSTAGTAEAKAIAGAIKGGKEGDTFDYKGVTFTIDTKTGNDGNGKVST 301

Query: 298 LEDGAKL 304
+G K+
Sbjct: 302 TINGEKV 308


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1351FLAGELLIN1453e-41 Flagellin signature.
		>FLAGELLIN#Flagellin signature.

Length = 507

Score = 145 bits (368), Expect = 3e-41
Identities = 107/326 (32%), Positives = 156/326 (47%), Gaps = 2/326 (0%)

Query: 2 AISVNTNVTSMRAQNNLNSANSSTQTSMERLSSGLRINSAKDDAAGLQISNRMTSQINGI 61
A +NTN S+ QNNLN + SS +++ERLSSGLRINSAKDDAAG I+NR TS I G+
Sbjct: 1 AQVINTNSLSLLTQNNLNKSQSSLSSAIERLSSGLRINSAKDDAAGQAIANRFTSNIKGL 60

Query: 62 GVAMRNANDGISIAQTAEGAMQESTNILQRMRDLSLQSANGSNSADDRAAMQKEMTSLQA 121
A RNANDGISIAQT EGA+ E N LQR+R+LS+Q+ NG+NS D ++Q E+
Sbjct: 61 TQASRNANDGISIAQTTEGALNEINNNLQRVRELSVQATNGTNSDSDLKSIQDEIQQRLE 120

Query: 122 ELTRISDTTSFGGQKLLNGDYGTQNFQVGANANETISLTLSDISADQLGSSGQSVDGALT 181
E+ R+S+ T F G K+L+ D QVGAN ETI++ L I LG G +V+G
Sbjct: 121 EIDRVSNQTQFNGVKVLSQD-NQMKIQVGANDGETITIDLQKIDVKSLGLDGFNVNGPKE 179

Query: 182 AAEITATVAGGTGSGEISFSYTPLDGSAETLTADLTGVTDADGMAAAINTALAGASISTG 241
A + +G +++ + + + T A + + A ++T
Sbjct: 180 ATVGDLKSSFKNVTGYDTYAVGANKYRVDVNSGAVVTDTTAPTVPDKVYVNAANGQLTTD 239

Query: 242 VIASSDGTDVTFGGIGNNGDVLTLTRKIDDGTTTAPATAFALGGDDSQVISVDDIDLTTE 301
++ D+ G T G + + D +
Sbjct: 240 DAENNTAVDLFKTTKSTAGTAEAKAIAGAIKGGKEGDTFDYKGVTFTID-TKTGNDGNGK 298

Query: 302 AGAQSAISTIDAAIIQIDSQRADLGA 327
+ + I + A++ A
Sbjct: 299 VSTTINGEKVTLTVADITAGAANVDA 324



Score = 89.7 bits (222), Expect = 1e-21
Identities = 59/278 (21%), Positives = 96/278 (34%), Gaps = 8/278 (2%)

Query: 124 TRISDTTSFGGQKLLNGDYGTQNFQVGANANETISLTLSDISADQLGSSGQSVDGALTAA 183
++ N I + G + T
Sbjct: 229 VNAANGQLTTDDAENNTAVDLFKTTKSTAGTAEAKAIAGAIKGGKEGDTFDYKGVTFTID 288

Query: 184 EITATVAGGTGSGEISFSYTPLDGSAETLTADLTGVTDADGMAAAINTALAGASISTGVI 243
T G S I+ L + T A + + G
Sbjct: 289 TKTGNDGNGKVSTTINGEKVTLTVADITAGAANVDAATLQSSKNVYTSVVNGQFTFDDKT 348

Query: 244 ASSDGTDVTFGGIGNNGDVLTLTRKIDDGTTTAPATAFALGGDD--------SQVISVDD 295
+ +T + T A L G +++
Sbjct: 349 KNESAKLSDLEANNAVKGESKITVNGAEYTANAAGDKVTLAGKTMFIDKTASGVSTLINE 408

Query: 296 IDLTTEAGAQSAISTIDAAIIQIDSQRADLGAVQNRMSFTINNLSNIQSNVTDARSRIQD 355
+ + +++ID+A+ ++D+ R+ LGA+QNR I NL N +N+ ARSRI+D
Sbjct: 409 DAAAAKKSTANPLASIDSALSKVDAVRSSLGAIQNRFDSAITNLGNTVTNLNSARSRIED 468

Query: 356 VDFAKETAELTKQQILSQTSSAMLAQANQLPQTALSLL 393
D+A E + ++K QIL Q +++LAQANQ+PQ LSLL
Sbjct: 469 ADYATEVSNMSKAQILQQAGTSVLAQANQVPQNVLSLL 506


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1352FLAGELLIN1462e-41 Flagellin signature.
		>FLAGELLIN#Flagellin signature.

Length = 507

Score = 146 bits (370), Expect = 2e-41
Identities = 107/326 (32%), Positives = 159/326 (48%), Gaps = 2/326 (0%)

Query: 2 AISVNTNVTSMRAQGNLNSANSSVQTSMERLSSGLRINSAKDDAAGLQISNRMTSQINGI 61
A +NTN S+ Q NLN + SS+ +++ERLSSGLRINSAKDDAAG I+NR TS I G+
Sbjct: 1 AQVINTNSLSLLTQNNLNKSQSSLSSAIERLSSGLRINSAKDDAAGQAIANRFTSNIKGL 60

Query: 62 GVAMRNANDGISIAQTAEGAMQESTNILQRMRDLSLQSANGSNSADDRAAMQKEITSLNA 121
A RNANDGISIAQT EGA+ E N LQR+R+LS+Q+ NG+NS D ++Q EI
Sbjct: 61 TQASRNANDGISIAQTTEGALNEINNNLQRVRELSVQATNGTNSDSDLKSIQDEIQQRLE 120

Query: 122 ELTRISDTTSFGGQKLLDGNYGTQNFQVGANANETISLTLSDISADQLGSSGQSVDGALT 181
E+ R+S+ T F G K+L + QVGAN ETI++ L I LG G +V+G
Sbjct: 121 EIDRVSNQTQFNGVKVLSQD-NQMKIQVGANDGETITIDLQKIDVKSLGLDGFNVNGPKE 179

Query: 182 AAEITATVAGGTGSGEISFSYTPLDGSAETLTADLTGVTDADGMAAAINTALAGASISTG 241
A + +G +++ + + + T A + + A ++T
Sbjct: 180 ATVGDLKSSFKNVTGYDTYAVGANKYRVDVNSGAVVTDTTAPTVPDKVYVNAANGQLTTD 239

Query: 242 VVASSDGTDVTFGGIGNNGDVLTLTRKIDDGTTTAPATAFALGGDDSQVNSVNDIDLTTE 301
++ D+ G T F G +++ D +
Sbjct: 240 DAENNTAVDLFKTTKSTAGTAEAKAIAGAIKGGKEGDT-FDYKGVTFTIDTKTGNDGNGK 298

Query: 302 AGSQSAISTIDAAISQIDSQRADLGA 327
+ + ++ I + A++ A
Sbjct: 299 VSTTINGEKVTLTVADITAGAANVDA 324



Score = 89.7 bits (222), Expect = 1e-21
Identities = 57/218 (26%), Positives = 93/218 (42%), Gaps = 5/218 (2%)

Query: 181 TAAEITATVAGGTGSGEISFSYTPLDGSAETLTADLTGVTDADGMAAA-----INTALAG 235
T T + T D +A D + + + +
Sbjct: 289 TKTGNDGNGKVSTTINGEKVTLTVADITAGAANVDAATLQSSKNVYTSVVNGQFTFDDKT 348

Query: 236 ASISTGVVASSDGTDVTFGGIGNNGDVLTLTRKIDDGTTTAPATAFALGGDDSQVNSVND 295
+ S + V D T A T F +N+
Sbjct: 349 KNESAKLSDLEANNAVKGESKITVNGAEYTANAAGDKVTLAGKTMFIDKTASGVSTLINE 408

Query: 296 IDLTTEAGSQSAISTIDAAISQIDSQRADLGAVQNRMNFTINNLSNIQSNVSDARSRIQD 355
+ + + +++ID+A+S++D+ R+ LGA+QNR + I NL N +N++ ARSRI+D
Sbjct: 409 DAAAAKKSTANPLASIDSALSKVDAVRSSLGAIQNRFDSAITNLGNTVTNLNSARSRIED 468

Query: 356 VDFAKETAELTKQQILSQTSSAMLAQANQLPQAALSLL 393
D+A E + ++K QIL Q +++LAQANQ+PQ LSLL
Sbjct: 469 ADYATEVSNMSKAQILQQAGTSVLAQANQVPQNVLSLL 506


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1354FLAGELLIN300.014 Flagellin signature.
		>FLAGELLIN#Flagellin signature.

Length = 507

Score = 30.4 bits (68), Expect = 0.014
Identities = 38/263 (14%), Positives = 70/263 (26%), Gaps = 12/263 (4%)

Query: 104 AESQKIGSAAVADATAALGEGSLTFGVDGKDFTVAVEAGDSLETVMKKINDAEDNVGVTA 163
K + ++ G T+ V + V V +G + D V V A
Sbjct: 174 VNGPKEATVGDLKSSFKNVTGYDTYAVGANKYRVDVNSGAVVTDT--TAPTVPDKVYVNA 231

Query: 164 TIINGDNGPQLVMTSDKTGTANNITVAATDTDGGTGLAKTFTMTELSAAKDAVLYVDGLK 223
T+ T + G K + K +D
Sbjct: 232 ANGQLTTDDAENNTAVDLFKTTKSTAGTAEAKAIAGAIKGGKEGDTFDYKGVTFTIDTKT 291

Query: 224 VTSASNEVENVITGVSLTLKDEDLSKSTTLTISPDTDSVKKSVEGFVEAYNALMGTVSDL 283
+ +V I G +TL D++ + S K V +
Sbjct: 292 GNDGNGKVSTTINGEKVTLTVADITAGAANVDAATLQSSKNVYTSVVNGQFTFDDKTKNE 351

Query: 284 SSYDAETEQAGILQGDSMIRSLQSQLRGVLSSSFDTSEGTTMLA----------NIGIKT 333
S+ ++ E ++G+S I ++ + T G TM
Sbjct: 352 SAKLSDLEANNAVKGESKITVNGAEYTANAAGDKVTLAGKTMFIDKTASGVSTLINEDAA 411

Query: 334 TQQGTLEIDEDILDKALNSDMSQ 356
+ + +D AL+ +
Sbjct: 412 AAKKSTANPLASIDSALSKVDAV 434


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1357HTHFIS440e-153 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 440 bits (1132), Expect = e-153
Identities = 172/480 (35%), Positives = 264/480 (55%), Gaps = 19/480 (3%)

Query: 7 RILLVGNQSERINRLSCVFEFLGEQVELID-----FDKLETYTKQTRFRAIVLPSENQSK 61
IL+ + + L+ G V + + + +V+P EN +
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDEN-AF 63

Query: 62 ELIQSLTGTLPWQPFLMLGERGDIKT------SNILGCIEEPLNYPQLTELLHFCQVYGQ 115
+L+ + P P L++ + T + +P + +L ++ +
Sbjct: 64 DLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPK 123

Query: 116 VKRPEIPTSANQTKLFRSLVGRSEGIANVRHLINQVAGSDATVLVLGQSGTGKEVVARNI 175
+ ++ + LVGRS + + ++ ++ +D T+++ G+SGTGKE+VAR +
Sbjct: 124 RRPSKLEDDSQD---GMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVARAL 180

Query: 176 HYISERRNGPFIPVNCGAIPPELLESELFGHEKGSFTGAISARKGRFELAEKGTLFLDEI 235
H +RRNGPF+ +N AIP +L+ESELFGHEKG+FTGA + GRFE AE GTLFLDEI
Sbjct: 181 HDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQTRSTGRFEQAEGGTLFLDEI 240

Query: 236 GDMPLQMQVKLLRVLQERMFERVGGSKSISADVRVVAATHRNLETMIEKGDFREDLYYRL 295
GDMP+ Q +LLRVLQ+ + VGG I +DVR+VAAT+++L+ I +G FREDLYYRL
Sbjct: 241 GDMPMDAQTRLLRVLQQGEYTTVGGRTPIRSDVRIVAATNKDLKQSINQGLFREDLYYRL 300

Query: 296 NVFPIEMPALCERKEDIPLLLQELVSRVYNEGRGRVRFTQRAIESLKEHLWSGNVRELSN 355
NV P+ +P L +R EDIP L++ V + EG RF Q A+E +K H W GNVREL N
Sbjct: 301 NVVPLRLPPLRDRAEDIPDLVRHFVQQAEKEGLDVKRFDQEALELMKAHPWPGNVRELEN 360

Query: 356 LVERLTILYPGGLVDVNDLPIKYRHIDVPEYCVEISEEQQERDALASIFNDEEPIEIPET 415
LV RLT LYP ++ + + R ++P+ +E + + +++ EE +
Sbjct: 361 LVRRLTALYPQDVITREIIENELRS-EIPDSPIEKAAARSGSLSISQAV--EENMRQYFA 417

Query: 416 RFPSELPPEGVNLKDLLAELEIDMIRQALDQQDSVVARAAEMLGIRRTTLVEKMRKYGLS 475
F LPP G+ +LAE+E +I AL +AA++LG+ R TL +K+R+ G+S
Sbjct: 418 SFGDALPPSGL-YDRVLAEMEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIRELGVS 476


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1359HTHFIS461e-162 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 461 bits (1189), Expect = e-162
Identities = 172/483 (35%), Positives = 251/483 (51%), Gaps = 39/483 (8%)

Query: 1 MSEGKLLLVEDDASLREALLDTLMLAHYDCVDVASAEEAILSLKANRYDMVISDVQMEGV 60
M+ +L+ +DDA++R L L A YD ++A + A D+V++DV M
Sbjct: 1 MTGATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDE 60

Query: 61 GGIGLLNYMQQHHPKIPVLLMTAYATIDNAVNAMKLGAVDYLAKPFSSEVLLNQVSRYL- 119
LL +++ P +PVL+M+A T A+ A + GA DYL KPF L+ + R L
Sbjct: 61 NAFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALA 120

Query: 120 ---------PAKVVEGTPIVADEKSI-ALLALAQRVAASDASVMIMGPSGSGKEVLARYI 169
+G P+V ++ + + R+ +D ++MI G SG+GKE++AR +
Sbjct: 121 EPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVARAL 180

Query: 170 HQNSQRVDQPFVAINCAAIPENMLEATLFGYEKGAFTGAYQACPGKFEQAQGGTLLLDEI 229
H +R + PFVAIN AAIP +++E+ LFG+EKGAFTGA G+FEQA+GGTL LDEI
Sbjct: 181 HDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQTRSTGRFEQAEGGTLFLDEI 240

Query: 230 SEMEVGLQAKLLRVLQEREVERLGGRKTIKLNVRVLATSNRDLKAMASSGEFREDLYYRI 289
+M + Q +LLRVLQ+ E +GGR I+ +VR++A +N+DLK + G FREDLYYR+
Sbjct: 241 GDMPMDAQTRLLRVLQQGEYTTVGGRTPIRSDVRIVAATNKDLKQSINQGLFREDLYYRL 300

Query: 290 NVFPLTWPSLNQRPADILPLARHLLQRHALIANRSEIPEFSECATRRLLTHRWPGNVREL 349
NV PL P L R DI L RH +Q+ ++ F + A + H WPGNVREL
Sbjct: 301 NVVPLRLPPLRDRAEDIPDLVRHFVQQAE--KEGLDVKRFDQEALELMKAHPWPGNVREL 358

Query: 350 DNVVQRALILSVSAEVTAADI----------------IIDSQELGFTAEV-------IPM 386
+N+V+R L +T I S L + V
Sbjct: 359 ENLVRRLTALYPQDVITREIIENELRSEIPDSPIEKAAARSGSLSISQAVEENMRQYFAS 418

Query: 387 VESKPAELDGLGDELKAQEHVIILETLTQCDGSRKLVAEKLGISARTLRYKMAKMRELGI 446
L E+ +IL LT G++ A+ LG++ TLR K+RELG+
Sbjct: 419 FGDALPPSGLYDRVLAEMEYPLILAALTATRGNQIKAADLLGLNRNTLRK---KIRELGV 475

Query: 447 QIP 449
+
Sbjct: 476 SVY 478


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1360FLGHOOKFLIE547e-13 Flagellar hook-basal body complex protein FliE signa...
		>FLGHOOKFLIE#Flagellar hook-basal body complex protein FliE

signature.
Length = 103

Score = 53.9 bits (129), Expect = 7e-13
Identities = 28/71 (39%), Positives = 45/71 (63%)

Query: 40 FSQLLSQAVGNVSELQSNAANLATRLDMGDTTVTLSDTVIAREKSSVAFEATVQVRNKLV 99
F+ L A+ +S+ Q+ A A + +G+ V L+D + +K+SV+ + +QVRNKLV
Sbjct: 33 FAGQLHAALDRISDTQTAARTQAEKFTLGEPGVALNDVMTDMQKASVSMQMGIQVRNKLV 92

Query: 100 EAYKEIMSMPV 110
AY+E+MSM V
Sbjct: 93 AAYQEVMSMQV 103


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1361FLGMRINGFLIF3013e-97 Flagellar M-ring protein signature.
		>FLGMRINGFLIF#Flagellar M-ring protein signature.

Length = 559

Score = 301 bits (771), Expect = 3e-97
Identities = 156/563 (27%), Positives = 263/563 (46%), Gaps = 49/563 (8%)

Query: 30 LGGVDMLRQLTMILALAICLAVAVFVMIWAQEPEYRPL-GQMSTAEMVQVLDALDKNQVK 88
L + ++ +I+A + +A+ V +++WA+ P+YR L +S + ++ L + +
Sbjct: 16 LNRLRANPRIPLIVAGSAAVAIVVAMVLWAKTPDYRTLFSNLSDQDGGAIVAQLTQMNIP 75

Query: 89 YEIQGD--VVKVPEDKYQDVKMLLSREGLDNQEANNDFLNKDSGFGVSQRMEQARLKHSQ 146
Y ++VP DK ++++ L+++GL A L FG+SQ EQ + +
Sbjct: 76 YRFANGSGAIEVPADKVHELRLRLAQQGLPKGGAVGFELLDQEKFGISQFSEQVNYQRAL 135

Query: 147 EQNLARVIEELKSVTRAKVILALPRENVFARNRSKPSATVVVSTRRS-GLSQEEVDSIVD 205
E LAR IE L V A+V LA+P+ ++F R + PSA+V V+ L + ++ ++V
Sbjct: 136 EGELARTIETLGPVKSARVHLAMPKPSLFVREQKSPSASVTVTLEPGRALDEGQISAVVH 195

Query: 206 IVASAVHNLEPNKVTVTDANGRLLNSGTQDGASAIARRELEIVQQKESEYRTKVESILMP 265
+V+SAV L P VT+ D +G LL G +L+ ES + ++E+IL P
Sbjct: 196 LVSSAVAGLPPGNVTLVDQSGHLLTQSNTSGRDL-NDAQLKFANDVESRIQRRIEAILSP 254

Query: 266 ILGPENFTSQVDVSMDFTAVEQTAKRYNPDLPALRSEMVVENNS-----AGGTSGGIPGA 320
I+G N +QV +DF EQT + Y+P+ A ++ + + G GG+PGA
Sbjct: 255 IVGNGNVHAQVTAQLDFANKEQTEEHYSPNGDASKATLRSRQLNISEQVGAGYPGGVPGA 314

Query: 321 LSNQPP---------------MAADIPQEVNAEESLAVSSGTSHKEATRNFELNTTISHT 365
LSNQP A + PQ + S + ++ + T N+E++ TI HT
Sbjct: 315 LSNQPAPPNEAPIATPPTNQQNAQNTPQTSTSTNSNSAGPRSTQRNETSNYEVDRTIRHT 374

Query: 366 RQQVGTLRRVSVSVAVDFKNGPVSEDGSVNRVPRTEQELANIRRLLEGAVGFNTQRGDII 425
+ VG + R+SV+V V++K + +P T ++ I L A+GF+ +RGD +
Sbjct: 375 KMNVGDIERLSVAVVVNYKTLADGKP-----LPLTADQMKQIEDLTREAMGFSDKRGDTL 429

Query: 426 EVVSVPFMDQLIEDAPPQEMWEQPWFWRAVKLVLGALVVLV----LILAVVRPMLKRLVY 481
VV+ PF + W+Q F + L+VLV L VRP L R V
Sbjct: 430 NVVNSPF-SAVDNTGGELPFWQQQSFIDQLLAAGRWLLVLVVAWILWRKAVRPQLTRRV- 487

Query: 482 PDSVKMPDEPQTGGELAEIEDQYAADTLGMLQRPEAEYSYADDGSILIPNLHKDDDMIKA 541
+ K E + E + LQ+ A + + + M +
Sbjct: 488 -EEAKAAQEQAQVRQETEEAVEVRLSKDEQLQQRRA--------NQRLGA----EVMSQR 534

Query: 542 IRALVANEPELSTQVVKNWLLED 564
IR + N+P + V++ W+ D
Sbjct: 535 IREMSDNDPRVVALVIRQWMSND 557


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1362FLGMOTORFLIG2871e-97 Flagellar motor switch protein FliG signature.
		>FLGMOTORFLIG#Flagellar motor switch protein FliG signature.

Length = 344

Score = 287 bits (735), Expect = 1e-97
Identities = 109/343 (31%), Positives = 191/343 (55%)

Query: 7 VEAKPEAAALKTSDLSGIEKTAILLLSLSESDAASILKHLEPKQVQKVGMAMAAMQDFGQ 66
+E K E L S L+G +K AILL+S+ ++ + K+L ++++ + +A ++
Sbjct: 1 MEEKKEKEILDVSALTGKQKAAILLVSIGSEISSKVFKYLSQEEIESLTFEIAKLETITS 60

Query: 67 EKVIGVHKLFLDEIQKYSSIGFNSEEFVRKALTAALGEDKAGNLIEQIIMGGGAKGLDSL 126
E V F + + I ++ R+ L +LG KA ++I + ++ + +
Sbjct: 61 ELKDNVLLEFKELMMAQEFIQKGGIDYARELLEKSLGTQKAVDIINNLGSALQSRPFEFV 120

Query: 127 KWMDARQVATIIQNEHPQIQTIVLSYLEPDQAAEIFGQFPENTRLDLMMRIANLEEVQPA 186
+ D + IQ EHPQ ++LSYL+P +A+ I P + ++ RIA ++ P
Sbjct: 121 RRADPANILNFIQQEHPQTIALILSYLDPQKASFILSSLPTEVQTNVARRIALMDRTSPE 180

Query: 187 ALQELNDIMEKQFAGQGGAQAAKMGGLKAAANIMNYLDTGVESHLMETMRESDEEMAQQI 246
++E+ ++EK+ A GG+ I+N D E ++E++ E D E+A++I
Sbjct: 181 VVREVERVLEKKLASLSSEDYTSAGGVDNVVEIINMADRKTEKFIIESLEEEDPELAEEI 240

Query: 247 QDLMFVFENLSEVDDMGIQVLLREVQQDVLIKALKGADDQLKEKLLSNMSKRAAELLRDD 306
+ MFVFE++ +DD IQ +LRE+ L KALK D ++EK+ NMSKRAA +L++D
Sbjct: 241 KKKMFVFEDIVLLDDRSIQRVLREIDGQELAKALKSVDIPVQEKIFKNMSKRAASMLKED 300

Query: 307 LEAMGPIRISEVEVAQKEILSIARRLSDSGEIMLGGGGGEEFL 349
+E +GP R +VE +Q++I+S+ R+L + GEI++ GG E+ L
Sbjct: 301 MEFLGPTRRKDVEESQQKIVSLIRKLEEQGEIVISRGGEEDVL 343


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1363FLGFLIH771e-18 Flagellar assembly protein FliH signature.
		>FLGFLIH#Flagellar assembly protein FliH signature.

Length = 228

Score = 76.8 bits (188), Expect = 1e-18
Identities = 57/205 (27%), Positives = 99/205 (48%), Gaps = 4/205 (1%)

Query: 47 AEEQTEVESILPPTLSEIEDIRAHAEQEGFG---EGLEKGHSEGLEKGRLEGLEQGHSEG 103
A Q E I+ P + IE+ EQ+ + E+G+ G+ +GR +G +QG+ EG
Sbjct: 16 APPQAEFVPIVEPEETIIEEAEPSLEQQLAQLQMQAHEQGYQAGIAEGRQQGHKQGYQEG 75

Query: 104 FSQGQQQGYLEGLQAASEMLQRFESLLSQFEAPLSILDTEIEKELLNTSMVLAKAVIGHE 163
+QG +QG E + + R + L+S+F+ L LD+ I L+ ++ A+ VIG
Sbjct: 76 LAQGLEQGLAEAKSQQAPIHARMQQLVSEFQTTLDALDSVIASRLMQMALEAARQVIGQT 135

Query: 164 LKTYPEHILAALRQGVDSLPIKDQKINVRVTPSDEILISELYSQAQLERNRWEIEADPSL 223
++ ++Q + P+ K +RV P D + ++ A L + W + DP+L
Sbjct: 136 PTVDNSALIKQIQQLLQQEPLFSGKPQLRVHPDDLQRVDDMLG-ATLSLHGWRLRGDPTL 194

Query: 224 TAGDCIIDCGRSHIDMTVETRIQSV 248
G C + +D +V TR Q +
Sbjct: 195 HPGGCKVSADEGDLDASVATRWQEL 219


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1365FLGFLIJ413e-07 Flagellar FliJ protein signature.
		>FLGFLIJ#Flagellar FliJ protein signature.

Length = 147

Score = 40.6 bits (94), Expect = 3e-07
Identities = 40/145 (27%), Positives = 70/145 (48%)

Query: 1 MARADPLLMVLKLAEDAEEQASLQLRSAQLELQRRQNQLDALQNYRLDYMKQMEQQQGQS 60
MA L + LAE E A+ L + Q+ + QL L +Y+ +Y +
Sbjct: 1 MAEHGALATLKDLAEKEVEDAARLLGEMRRGCQQAEEQLKMLIDYQNEYRNNLNSDMSAG 60

Query: 61 ISASHYHQFHQFVRQIDTAIIQQVNTVQDADNQRQHRQVYWQEKQQKRKAVELLLANKAE 120
I+++ + + QF++ ++ AI Q + + W+EK+Q+ +A + L ++
Sbjct: 61 ITSNRWINYQQFIQTLEKAITQHRQQLNQWTQKVDIALNSWREKKQRLQAWQTLQERQST 120

Query: 121 KAQLAELRAEQKMVDEFASQQFYRK 145
A LAE R +QK +DEFA + RK
Sbjct: 121 AALLAENRLDQKKMDEFAQRAAMRK 145


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1366FLGHOOKFLIK485e-08 Flagellar hook-length control protein signature.
		>FLGHOOKFLIK#Flagellar hook-length control protein signature.

Length = 375

Score = 47.9 bits (113), Expect = 5e-08
Identities = 32/109 (29%), Positives = 55/109 (50%), Gaps = 1/109 (0%)

Query: 381 MNQQLITMVSNGIQQAEIRLDPPELGQMMVRIQVQGDTTQVQFQVSQHQTRDLVEQAMPR 440
++Q + G Q AE+RL P +LG++ + ++V + Q+Q R +E A+P
Sbjct: 244 LSQHISLFTRQGQQSAELRLHPQDLGEVQISLKVDDNQAQIQMVSPHQHVRAALEAALPV 303

Query: 441 LREMLAEQGMQLTDGQVSQGDGRNSQGEQGSGAGNGTATAETDEISSEE 489
LR LAE G+QL +S G+ + Q + S TA + ++ E+
Sbjct: 304 LRTQLAESGIQLGQSNIS-GESFSGQQQAASQQQQSQRTANHEPLAGED 351


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1368FLGMOTORFLIM2495e-83 Flagellar motor switch protein FliM signature.
		>FLGMOTORFLIM#Flagellar motor switch protein FliM signature.

Length = 344

Score = 249 bits (638), Expect = 5e-83
Identities = 87/326 (26%), Positives = 168/326 (51%), Gaps = 11/326 (3%)

Query: 1 MSDLLSQDEIDALLHGVDDVEEDMID----DNELDARSYDFSSQDRIVRGRMPTLEIVNE 56
M+++LSQDEID LL + + + D + YDF D+ + +M TL +++E
Sbjct: 1 MTEVLSQDEIDQLLTAISSGDASIEDARPISDTRKITLYDFRRPDKFSKEQMRTLSLMHE 60

Query: 57 RFARHLRISMFNMMRRAAEVSINGVQMLKFGEYVHTLFVPTSLNMVRFSPLKGTALITME 116
FAR S+ +R V + V L + E++ ++ P++L ++ PLKG A++ ++
Sbjct: 61 TFARLTTTSLSAQLRSMVHVHVASVDQLTYEEFIRSIPTPSTLAVITMDPLKGNAVLEVD 120

Query: 117 ARLVFILVDNFFGGDGRFHAKIEGREFTPTERRIVQLLLKIIFEDYKEAWAPVMEVQFDY 176
+ F ++D FGG G+ R+ T E +++ ++ I + +E+W V++++
Sbjct: 121 PSITFSIIDRLFGGTGQAAKVQ--RDLTDIENSVMEGVIVRILANVRESWTQVIDLRPRL 178

Query: 177 LDSEVNPAMANIVSPTEVVVVSSFHIEVDGGGGDFHITMPYSMIEPIRELLDAG--VQSD 234
E NP A IV P+E+VV+ + +V G + +PY IEPI L + S
Sbjct: 179 GQIETNPQFAQIVPPSEMVVLVTLETKVGEEEGMMNFCIPYITIEPIISKLSSQFWFSSV 238

Query: 235 TQDTDMRWSQALRDEIMDVDVGIDATIVEHKLTLREVLEFKAGDVIPVE---LPEHIILK 291
+ + ++ LRD++ VD+ + A + +L++R++L + GD+I + + + +L
Sbjct: 239 RRSSTTQYMGVLRDKLSTVDMDVVAEVGSLRLSVRDILGLRVGDIIRLHDTHVGDPFVLS 298

Query: 292 VEDLPTYRCKMGKAKDNLALKICEKI 317
+ + + C+ G +A +I E+I
Sbjct: 299 IGNRKKFLCQPGVVGKKIAAQILERI 324


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1369FLGMOTORFLIN1132e-35 Flagellar motor switch protein FliN signature.
		>FLGMOTORFLIN#Flagellar motor switch protein FliN signature.

Length = 137

Score = 113 bits (283), Expect = 2e-35
Identities = 57/119 (47%), Positives = 81/119 (68%)

Query: 7 DDWAAAMAEQAIEEAKAVELDEFNSDGAPLSEEEASKLDAIMDIPVTISMEVGRSFINIR 66
D WA A+ EQ K+ F G +D IMDIPV +++E+GR+ + I+
Sbjct: 17 DLWADALNEQKATTTKSAADAVFQQLGGGDVSGAMQDIDLIMDIPVKLTVELGRTRMTIK 76

Query: 67 NLLQLNQGSVVELDRVAGEPLDVMVNGTLIAHGEVVVVNDKFGIRLTDVISQTERIKKL 125
LL+L QGSVV LD +AGEPLD+++NG LIA GEVVVV DK+G+R+TD+I+ +ER+++L
Sbjct: 77 ELLRLTQGSVVALDGLAGEPLDILINGYLIAQGEVVVVADKYGVRITDIITPSERMRRL 135


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1371FLGBIOSNFLIP2704e-94 Escherichia coli: Flagellar biosynthetic protein Fl...
		>FLGBIOSNFLIP#Escherichia coli: Flagellar biosynthetic protein FliP

signature.
Length = 245

Score = 270 bits (693), Expect = 4e-94
Identities = 126/246 (51%), Positives = 180/246 (73%), Gaps = 3/246 (1%)

Query: 2 MKWILVIVGLTLCLAAPAAFAENGILPAVTVSTGADGSTQYSVTMQILLLMTALSFIPAM 61
M+ +L + + L L P AFA+ LP +T G +S+ +Q L+ +T+L+FIPA+
Sbjct: 1 MRRLLSVAPVLLWLITPLAFAQ---LPGITSQPLPGGGQSWSLPVQTLVFITSLTFIPAI 57

Query: 62 VIMLTSFTRIIVVLSILRQAIGLQQTPSNQVLIGISMFMTFFIMSPVFDKIYDQAVQPYI 121
++M+TSFTRII+V +LR A+G P NQVL+G+++F+TFFIMSPV DKIY A QP+
Sbjct: 58 LLMMTSFTRIIIVFGLLRNALGTPSAPPNQVLLGLALFLTFFIMSPVIDKIYVDAYQPFS 117

Query: 122 EQGMPLQDAFTKGQGPLKDFMLAQTRLTDLDTFIEISGYQNINEPEDAPMTVIIPAFITS 181
E+ + +Q+A KG PL++FML QTR DL F ++ + PE PM +++PA++TS
Sbjct: 118 EEKISMQEALEKGAQPLREFMLRQTREADLGLFARLANTGPLQGPEAVPMRILLPAYVTS 177

Query: 182 ELKTAFQIGFMLFVPFLVLDLVVASILMAMGMMMLSPMIVSLPFKIMLFVLVDGWSLVMG 241
ELKTAFQIGF +F+PFL++DLV+AS+LMA+GMMM+ P ++LPFK+MLFVLVDGW L++G
Sbjct: 178 ELKTAFQIGFTIFIPFLIIDLVIASVLMALGMMMVPPATIALPFKLMLFVLVDGWQLLVG 237

Query: 242 TLANSF 247
+LA SF
Sbjct: 238 SLAQSF 243


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1372TYPE3IMQPROT434e-09 Type III secretion system inner membrane Q protein ...
		>TYPE3IMQPROT#Type III secretion system inner membrane Q protein

family signature.
Length = 86

Score = 42.8 bits (101), Expect = 4e-09
Identities = 24/81 (29%), Positives = 44/81 (54%)

Query: 4 ESLVDIFREALAVIVIIVSMIIVPGLIIGLVVAVFQAATSINEQTLSFLPRLLTTLLALM 63
+ LV +AL +++I+ + IIGL+V +FQ T + EQTL F +LL L L
Sbjct: 2 DDLVFAGNKALYLVLILSGWPTIVATIIGLLVGLFQTVTQLQEQTLPFGIKLLGVCLCLF 61

Query: 64 LMGHLLIQMMMDFFMQMVDMI 84
L+ ++++ + Q++ +
Sbjct: 62 LLSGWYGEVLLSYGRQVIFLA 82


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1373TYPE3IMRPROT1205e-35 Type III secretion system inner membrane R protein ...
		>TYPE3IMRPROT#Type III secretion system inner membrane R protein

family signature.
Length = 261

Score = 120 bits (302), Expect = 5e-35
Identities = 80/243 (32%), Positives = 139/243 (57%), Gaps = 1/243 (0%)

Query: 15 YLWPLTRISSMFMVMAVFGATTTPTRVRLLLSVTVTAAVAPVLPAMPNIDLFSLSAAFVT 74
Y WPL R+ ++ + + P RV+L L++ +T A+AP LPA ++ +FS A ++
Sbjct: 16 YFWPLLRVLALISTAPILSERSVPKRVKLGLAMMITFAIAPSLPA-NDVPVFSFFALWLA 74

Query: 75 AQQIIIGVAMGFATLLLMQTFVLTGQIIGMQTSLGFASMVDPSSGQQTPVVGNFFLLLTT 134
QQI+IG+A+GF G+IIG+Q L FA+ VDP+S PV+ +L
Sbjct: 75 VQQILIGIALGFTMQFAFAAVRTAGEIIGLQMGLSFATFVDPASHLNMPVLARIMDMLAL 134

Query: 135 MIFLAVDGHLLLIKMVIASFESIPVSMQGLSLASYRLFTEFVGYMFGAALTMSLSAIVAL 194
++FL +GHL LI +++ +F ++P+ + L+ ++ T+ +F L ++L I L
Sbjct: 135 LLFLTFNGHLWLISLLVDTFHTLPIGGEPLNSNAFLALTKAGSLIFLNGLMLALPLITLL 194

Query: 195 LTINLSFGVMTRASPQLNIFAIGFPVTMVAGLFILWLTLSPIMSHFDEVWRETQILLCNA 254
LT+NL+ G++ R +PQL+IF IGFP+T+ G+ ++ + I + ++ E LL +
Sbjct: 195 LTLNLALGLLNRMAPQLSIFVIGFPLTLTVGISLMAALMPLIAPFCEHLFSEIFNLLADI 254

Query: 255 LEL 257
+
Sbjct: 255 ISE 257


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1374TYPE3IMSPROT339e-117 Type III secretion system inner membrane S protein ...
		>TYPE3IMSPROT#Type III secretion system inner membrane S protein

family signature.
Length = 354

Score = 339 bits (871), Expect = e-117
Identities = 108/359 (30%), Positives = 181/359 (50%), Gaps = 15/359 (4%)

Query: 7 SQEKTEEATSRKLQQAKDKGQVARSKDLGTSAVLIAASVGLLMTGPNIAQAMFNIMNKMY 66
S EKTE+ T +K++ A+ KGQVA+SK++ ++A+++A S L+ F +K+
Sbjct: 2 SGEKTEQPTPKKIRDARKKGQVAKSKEVVSTALIVALSAMLMGLSD----YYFEHFSKLM 57

Query: 67 TLSRDEIFD--TNQMMNVWGVVGSELAFPLLGFIVFLALIAFAGNIALGGISFSVSAFMP 124
+ ++ + + + V V E + + AL+A A ++ G S A P
Sbjct: 58 LIPAEQSYLPFSQALSYVVDNVLLEFFYLCFPLLTVAALMAIASHVVQYGFLISGEAIKP 117

Query: 125 KASKMSPVAGFKRMFGVQAVVELAKGIAKFSVVAITAYLLLSIYLNDILLLSQEHLPGNI 184
K++P+ G KR+F ++++VE K I K +++I ++++ L +L L I
Sbjct: 118 DIKKINPIEGAKRIFSIKSLVEFLKSILKVVLLSILIWIIIKGNLVTLLQLPT----CGI 173

Query: 185 YHALDLIVWIFILLCAST----LLIVMIDVPFQIWNHAKQLKMTKQEIKDEYKDTEGKPE 240
L+ I L ++I + D F+ + + K+LKM+K EIK EYK+ EG PE
Sbjct: 174 ECITPLLGQILRQLMVICTVGFVVISIADYAFEYYQYIKELKMSKDEIKREYKEMEGSPE 233

Query: 241 VKGRIRQLQREMAQRRMMGEVPNADVIVVNPEHYAVAVKYDAGRSTAPFVVAKGVDEVAF 300
+K + RQ +E+ R M V + V+V NP H A+ + Y G + P V K D
Sbjct: 234 IKSKRRQFHQEIQSRNMRENVKRSSVVVANPTHIAIGILYKRGETPLPLVTFKYTDAQVQ 293

Query: 301 KIREIAREHDVAIVSAPPLARAIYHTTKIDQEIPEGLFTAVAQVLAYVFQLR-QYQKGK 358
+R+IA E V I+ PLARA+Y +D IP A A+VL ++ + + Q +
Sbjct: 294 TVRKIAEEEGVPILQRIPLARALYWDALVDHYIPAEQIEATAEVLRWLERQNIEKQHSE 352


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1376PF05272381e-04 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 37.7 bits (87), Expect = 1e-04
Identities = 42/265 (15%), Positives = 74/265 (27%), Gaps = 43/265 (16%)

Query: 59 SSAMFTDLAEERVTLGVQSGGRAPNVRAESRA----NPTP-----APDSLQALLERQQSR 109
+ A+ D++ G GG P R S P D L+ + +R
Sbjct: 380 ARALLADVSSPTAAAGGAGGGEPPKKRDPSAGAGTDPGGPGGGDDGEDPFGEWLDDEVAR 439

Query: 110 ISQQTQSRSSDEL--------DMPEWAKGLQAQVKKNEPVKAEFTP-NRAPDSFNGQKQN 160
+ + + P A + + +PV P +AP
Sbjct: 440 LRLRGRWLLKPRRAALIEALRSAPALAGCVAFDELREQPVAVRAFPWRKAPGPLEDADVL 499

Query: 161 NTAEIDAMKQELASIRNLLTHQVSSLMVEQKNRIDPVGAMLESKLLD--AEFSPAIAKKL 218
A+ T + + + NR+ P ++++ D + L
Sbjct: 500 RLADYVETTYGTGEASAQ-TTEQAINVAADMNRVHPFRDWVKAQQWDEVPRLEKWLVHVL 558

Query: 219 SSLSEHYSPAE-----------LVASLPRSLANMLDNQGDDIVRQGGVVAFVGPTGVGKT 267
+ Y P L+ + R + G + V G G+GK+
Sbjct: 559 GKTPDDYKPRRLRYLQLVGKYILMGHVARVM-----EPG---CKFDYSVVLEGTGGIGKS 610

Query: 268 TTVAKLAARFAAYHGSDQVALITTD 292
T + L SD I T
Sbjct: 611 TLINTL---VGLDFFSDTHFDIGTG 632


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1379HTHFIS881e-23 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 88.3 bits (219), Expect = 1e-23
Identities = 35/121 (28%), Positives = 54/121 (44%), Gaps = 3/121 (2%)

Query: 14 KILVVDDFSTMRRIIKNLLRDLGFNNTQEADDGSTALPMLQKGDFDFVVTDWNMPGMQGI 73
ILV DD + +R ++ L G++ + +T + GD D VVTD MP
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRI-TSNAATLWRWIAAGDGDLVVTDVVMPDENAF 63

Query: 74 DLLKAIRADDNLKHLPVLMVTAEAKREQIITAAQAGVNGYVVKPFTAATLKEKLEKIFER 133
DLL I+ LPVL+++A+ I A++ G Y+ KPF L + +
Sbjct: 64 DLLPRIKKAR--PDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAE 121

Query: 134 L 134

Sbjct: 122 P 122


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1381PF06580442e-06 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 43.7 bits (103), Expect = 2e-06
Identities = 13/77 (16%), Positives = 32/77 (41%), Gaps = 10/77 (12%)

Query: 448 DLDKNLVEALADPLV--HLVRNSVDHGIEMPDAREENGKTRTGTITLSASQEGDHILLKI 505
++ +++ P++ LV N + HGI + G I L +++ + L++
Sbjct: 245 QINPAIMDVQVPPMLVQTLVENGIKHGIA--------QLPQGGKILLKGTKDNGTVTLEV 296

Query: 506 EDDGAGMDPDKLKGIAI 522
E+ G+ + +
Sbjct: 297 ENTGSLALKNTKESTGT 313


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1382HTHFIS665e-14 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 66.4 bits (162), Expect = 5e-14
Identities = 30/135 (22%), Positives = 61/135 (45%), Gaps = 7/135 (5%)

Query: 2 GIKVLVVDDSSFFRRRVSEIVNQDPELEVVGTACNGAEAVKMAAELNPQVITMDIEMPVM 61
G +LV DD + R +++ +++ V N A + A + ++ D+ MP
Sbjct: 3 GATILVADDDAAIRTVLNQALSR--AGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDE 60

Query: 62 DGITAVKEIMASKP-IPILMFSSLTHDGAKATLEALDAGALDFLPKRF--EDIASNKDDA 118
+ + I ++P +P+L+ S+ + ++A + GA D+LPK F ++ A
Sbjct: 61 NAFDLLPRIKKARPDLPVLVMSA--QNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRA 118

Query: 119 IALLQQRIRALGRRR 133
+A ++R L
Sbjct: 119 LAEPKRRPSKLEDDS 133


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1383INTIMIN290.019 Intimin signature.
		>INTIMIN#Intimin signature.

Length = 939

Score = 28.9 bits (64), Expect = 0.019
Identities = 22/106 (20%), Positives = 38/106 (35%)

Query: 109 SSSQAVNLKSSDLVVDESKAESGSRQEPVKVNSLLEPEQKKASNNVIANAEQQAVASERD 168
S V LKS A++ + N+++ +Q KAS I + AVA+ +D
Sbjct: 617 SGKATVTLKSDKPGQVVVSAKTAEMTSALNANAVIFVDQTKASITEIKADKTTAVANGQD 676

Query: 169 ITAGLSDKPEERNTPSNMNAAFSSKRVPKHAVTLTETPDGVKLISL 214
+ SN F++ T +G ++L
Sbjct: 677 AITYTVKVMKGDKPVSNQEVTFTTTLGKLSNSTEKTDTNGYAKVTL 722


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1388TYPE3IMSPROT663e-16 Type III secretion system inner membrane S protein ...
		>TYPE3IMSPROT#Type III secretion system inner membrane S protein

family signature.
Length = 354

Score = 65.6 bits (160), Expect = 3e-16
Identities = 23/98 (23%), Positives = 41/98 (41%), Gaps = 10/98 (10%)

Query: 6 NPKK-AVALSYQPGT--APKVSAKGEDRLAEEIIALAQQAGIPIHQDEYLCDFL-QRLEV 61
NP A+ + Y+ G P V+ K D + + +A++ G+PI Q L L V
Sbjct: 263 NPTHIAIGILYKRGETPLPLVTFKYTDAQVQTVRKIAEEEGVPILQRIPLARALYWDALV 322

Query: 62 GDEIPSELYLLIAELIAFVYVLDGKFPEKWNNMHQKIM 99
IP+E AE++ ++ H +++
Sbjct: 323 DHYIPAEQIEATAEVLRWLERQ------NIEKQHSEML 354


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1390VACJLIPOPROT2255e-76 VacJ lipoprotein signature.
		>VACJLIPOPROT#VacJ lipoprotein signature.

Length = 251

Score = 225 bits (574), Expect = 5e-76
Identities = 86/208 (41%), Positives = 121/208 (58%), Gaps = 3/208 (1%)

Query: 39 PRDPIEGFNRAMWDFNYLFMDRYFYRPVAHGYNDYIPHPVKSGVNNFVLNLEEPSTLVNN 98
DP+EGFNR M++FN+ +D Y RPVA + DY+P P ++G++NF NLEEP+ +VN
Sbjct: 28 RSDPLEGFNRTMYNFNFNVLDPYIVRPVAVAWRDYVPQPARNGLSNFTGNLEEPAVMVNY 87

Query: 99 TLQGNWGWAANAGGRFTVNTTLGLLGVIDVAEMMGMTRK---QDAFNEVLGYYGVPNGPY 155
LQG+ RF +NT LG+ G IDVA M + F LG+YGV GPY
Sbjct: 88 FLQGDPYQGMVHFTRFFLNTILGMGGFIDVAGMANPKLQRTEPHRFGSTLGHYGVGYGPY 147

Query: 156 FMAPFFGPYVTRELASDWVDDLYFPLSELTFWQSVLKWGLKNLHTRASAIDQERLVDNAL 215
PF+G + R+ D D LY LS LT+ SV KW L+ + TRA +D + L+ +
Sbjct: 148 VQLPFYGSFTLRDDGGDMADALYPVLSWLTWPMSVGKWTLEGIETRAQLLDSDGLLRQSS 207

Query: 216 DPYTFVKDAYFQHMDYKVYDGDIPQSDD 243
DPY V++AYFQ D+ G++ ++
Sbjct: 208 DPYIMVREAYFQRHDFIANGGELKPQEN 235


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1391HTHFIS965e-24 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 96.4 bits (240), Expect = 5e-24
Identities = 30/101 (29%), Positives = 45/101 (44%)

Query: 7 TILFVEDDPVFRKLVTSYLESRGADVTEAENGEQGLISFKSQQFDIVIADLSMPKLGGLD 66
TIL +DD R ++ L G DV N + D+V+ D+ MP D
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64

Query: 67 MLEAMNQHSPSTPSIIISGNQAMSDVIEALRRGASDYLVKP 107
+L + + P P +++S I+A +GA DYL KP
Sbjct: 65 LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKP 105


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1396NUCEPIMERASE280.008 Nucleotide sugar epimerase signature.
		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

Length = 334

Score = 28.2 bits (63), Expect = 0.008
Identities = 17/88 (19%), Positives = 32/88 (36%), Gaps = 10/88 (11%)

Query: 21 EIYKELNTCRDFGLKDQITRAAVSIASNIAEGEERES------KAESARFLYFAKGSSGE 74
++Y RDF D I A + + I + + + A A + + G+S
Sbjct: 206 DVYNYGKMKRDFTYIDDIAEAIIRLQDVIPHADTQWTVETGTPAASIAPYRVYNIGNSSP 265

Query: 75 LATQIYIAIEIGVIEKQIGLKLIKEARE 102
+ YI +E +G++ K
Sbjct: 266 VELMDYIQA----LEDALGIEAKKNMLP 289


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1398NUCEPIMERASE1791e-55 Nucleotide sugar epimerase signature.
		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

Length = 334

Score = 179 bits (455), Expect = 1e-55
Identities = 80/356 (22%), Positives = 142/356 (39%), Gaps = 48/356 (13%)

Query: 1 MKILVTGGAGFIGSAVVRHIINNTQDSVINVDKLT--YAGNL-ESLSSIESNERYVFEQV 57
MK LVTG AGFIG V + ++ V+ +D L Y +L ++ + + + F ++
Sbjct: 1 MKYLVTGAAGFIGFHVSKRLLEAG-HQVVGIDNLNDYYDVSLKQARLELLAQPGFQFHKI 59

Query: 58 DICDRAELDRVFAQCQPNAVMHLAAESHVDRSITGPADFIQTNIVGTYTLLEATRAYWNT 117
D+ DR + +FA V V S+ P + +N+ G +LE R
Sbjct: 60 DLADREGMTDLFASGHFERVFISPHRLAVRYSLENPHAYADSNLTGFLNILEGCRHN--- 116

Query: 118 LSKGAKQAFRFHHISTDEVYGDLPHPDEVESGKELPLFTETTAYEPSSPYSASKASSDHL 177
+ + S+ VYG +P T+ + P S Y+A+K +++ +
Sbjct: 117 ------KIQHLLYASSSSVYGLNRK---------MPFSTDDSVDHPVSLYAATKKANELM 161

Query: 178 VRAWLRTYGLPTIVTNCSNNYGPYHFPEKLIPLVILNALEGKPLPIYGKGDQIRDWLYVE 237
+ YGLP YGP+ P+ + LEGK + +Y G RD+ Y++
Sbjct: 162 AHTYSHLYGLPATGLRFFTVYGPWGRPDMALFKFTKAMLEGKSIDVYNYGKMKRDFTYID 221

Query: 238 DHARALYKVV------------------TEGLVGETYNIGGHNEKQNLEVVQTICSILDF 279
D A A+ ++ YNIG + + ++ +Q + L
Sbjct: 222 DIAEAIIRLQDVIPHADTQWTVETGTPAASIAPYRVYNIGNSSPVELMDYIQALEDALGI 281

Query: 280 LVPKETKYSQQITYVTDRPGHDRRYAIDSSKMQRELGWTPVETFETGLRKTIEWYL 335
K + +PG + D+ + +G+TP T + G++ + WY
Sbjct: 282 EAKKN--------MLPLQPGDVLETSADTKALYEVIGFTPETTVKDGVKNFVNWYR 329


73Spea_1432Spea_1441N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_1432-117-0.178124response regulator receiver modulated serine
Spea_1433-2150.386882phosphonate ABC transporter periplasmic
Spea_1434-1150.544985multi-sensor hybrid histidine kinase
Spea_14350131.136150Fis family two component sigma54 specific
Spea_14361131.371961putative hydrolase
Spea_14370141.459723dTDP-4-dehydrorhamnose reductase
Spea_14381151.511728hypothetical protein
Spea_14390210.884994glycoside hydrolase family 3
Spea_14400190.6143023'(2'),5'-bisphosphate nucleotidase
Spea_1441-2140.473495fructokinase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1432HTHFIS832e-19 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 83.3 bits (206), Expect = 2e-19
Identities = 37/163 (22%), Positives = 67/163 (41%), Gaps = 6/163 (3%)

Query: 12 KIIVVEDCYSERCLLLTLLESMGFTAQGFSNAQEAIELLQREHVDMVITDWMMPKISGIE 71
I+V +D + R +L L G+ + SNA + D+V+TD +MP + +
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64

Query: 72 LCKTIKSMPCSPYTILLTGNSQNAHLIEGIESGADDFIAKPF---HSGVLKVRILAGLRI 128
L IK ++++ + I+ E GA D++ KPF + R LA +
Sbjct: 65 LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPK- 123

Query: 129 IAMQQKLESHNQALNNMLLKEQGYLNNLKHDLSLAAQLQRALL 171
KLE +Q ++ + + + L+ Q L+
Sbjct: 124 -RRPSKLEDDSQDGMPLVGRSAA-MQEIYRVLARLMQTDLTLM 164


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1434HTHFIS819e-18 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 81.0 bits (200), Expect = 9e-18
Identities = 28/102 (27%), Positives = 51/102 (50%)

Query: 878 ILLAEDSPANQIVASALLSKAGFKVEIANNGIEALKMASAKDYGLILMDMRMPEMDGIEA 937
IL+A+D A + V + LS+AG+ V I +N + +A D L++ D+ MP+ + +
Sbjct: 6 ILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFDL 65

Query: 938 TQKILQRNPSQVVIAMTANVQKEDVEQCMNAGMKAFVPKPVN 979
+I + P V+ M+A + G ++PKP +
Sbjct: 66 LPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFD 107


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1435HTHFIS490e-173 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 490 bits (1262), Expect = e-173
Identities = 163/484 (33%), Positives = 255/484 (52%), Gaps = 16/484 (3%)

Query: 5 SSFTTLLVEDSMSLGALYTEYLRTEGARVTHVNHGSDALNELKRWQPDLLVLDIQLPDMS 64
+ T L+ +D ++ + + L G V ++ + + DL+V D+ +PD +
Sbjct: 2 TGATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDEN 61

Query: 65 GMDILEIVQSEYPDVTVIMITAHGSIDIAVDAMRSGAFDFLIKPFDAKRLSITVRNALKQ 124
D+L ++ PD+ V++++A + A+ A GA+D+L KPFD L + AL +
Sbjct: 62 AFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAE 121

Query: 125 RQLVNLVAKYESSLPKPHYMGFIGESLAMQTVYKTIDCVASSKASAFIIGESGTGKEVCA 184
+ + M +G S AMQ +Y+ + + + + I GESGTGKE+ A
Sbjct: 122 PKR----RPSKLEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVA 177

Query: 185 HAIHNAGNRSDGPFVALNCASIPKDLIESEIFGHTKGAFTGAIANRDGAATRAHKGTLFL 244
A+H+ G R +GPFVA+N A+IP+DLIESE+FGH KGAFTGA G +A GTLFL
Sbjct: 178 RALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQTRSTGRFEQAEGGTLFL 237

Query: 245 DEICEMDLELQSKLLRFIQTGVFQRVGATKEEKVDVRFVSATNRMPWDEVKAGRFREDLF 304
DEI +M ++ Q++LLR +Q G + VG + DVR V+ATN+ + G FREDL+
Sbjct: 238 DEIGDMPMDAQTRLLRVLQQGEYTTVGGRTPIRSDVRIVAATNKDLKQSINQGLFREDLY 297

Query: 305 YRLHVIPIELPPLRMRGKDILLLASSLLKEYNKEEGKTFKGFSPEAKQCLKSYPWPGNVR 364
YRL+V+P+ LPPLR R +DI L +++ K EG K F EA + +K++PWPGNVR
Sbjct: 298 YRLNVVPLRLPPLRDRAEDIPDLVRHFVQQAEK-EGLDVKRFDQEALELMKAHPWPGNVR 356

Query: 365 QLQNVIRQIVVLNDSETIEIDMLPIQLTSTSAIKSEVAKPQAAVVKSQSLRGDSDASSFL 424
+L+N++R++ L + I +++ +L S I + AA S S+ + +
Sbjct: 357 ELENLVRRLTALYPQDVITREIIENELRSE--IPDSPIEKAAARSGSLSISQAVEENMRQ 414

Query: 425 DGIERAAFSGSEQYAKSANEKSDDIVPLWKTEKQTIENAIARCDGNVPKAAALLDISAST 484
L + E I A+ GN KAA LL ++ +T
Sbjct: 415 YFASFGDALPPSGLYDRV---------LAEMEYPLILAALTATRGNQIKAADLLGLNRNT 465

Query: 485 IYRK 488
+ +K
Sbjct: 466 LRKK 469


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1437NUCEPIMERASE529e-10 Nucleotide sugar epimerase signature.
		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

Length = 334

Score = 52.5 bits (126), Expect = 9e-10
Identities = 46/210 (21%), Positives = 80/210 (38%), Gaps = 30/210 (14%)

Query: 1 MRILITGAAGQLG----QALLS----IAGLTQVNLAERTVAQQMLVALLPEALECIETTD 52
M+ L+TGAAG +G + LL + G+ +N +Q + LL +
Sbjct: 1 MKYLVTGAAGFIGFHVSKRLLEAGHQVVGIDNLNDYYDVSLKQARLELLAQP-------- 52

Query: 53 EVIGVSHQALDICDIDSIRKAFDTIAPDVVINCAAYNAVDKAEFDIDKAMLINAEGPKLL 112
G +D+ D + + F + + V AV + + N G +
Sbjct: 53 ---GFQFHKIDLADREGMTDLFASGHFERVFISPHRLAVRYSLENPHAYADSNLTGFLNI 109

Query: 113 AGECQRHNI-RLVHISTDFVFDGELLRAYTEQDSPA-PLSVYGKSKLEGERWV---SDIL 167
C+ + I L++ S+ V+ ++ DS P+S+Y +K E S +
Sbjct: 110 LEGCRHNKIQHLLYASSSSVYGLNRKMPFSTDDSVDHPVSLYAATKKANELMAHTYSHLY 169

Query: 168 GSKATIIRTSWLYSCYG------HNFVKTM 191
G AT +R +Y +G F K M
Sbjct: 170 GLPATGLRFFTVYGPWGRPDMALFKFTKAM 199


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1441ACETATEKNASE300.013 Acetate kinase family signature.
		>ACETATEKNASE#Acetate kinase family signature.

Length = 400

Score = 29.8 bits (67), Expect = 0.013
Identities = 9/42 (21%), Positives = 18/42 (42%), Gaps = 1/42 (2%)

Query: 211 MQEGDVIACAAFERYVDRLARSLAHVINVLDP-DIIVLGGGV 251
+ GD A A + R+ +++ + D+IV G+
Sbjct: 291 FKNGDKRAQLALNVFAYRVKKTIGSYAAAMGGVDVIVFTAGI 332


74Spea_1561Spea_1564N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_1561-2171.549205TetR family transcriptional regulator
Spea_1562-2181.995004RND family efflux transporter MFP subunit
Spea_15630161.120144acriflavin resistance protein
Spea_1564-114-1.683738purine phosphorylase family 1
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1561HTHTETR602e-13 TetR bacterial regulatory protein HTH signature.
		>HTHTETR#TetR bacterial regulatory protein HTH signature.

Length = 215

Score = 60.4 bits (146), Expect = 2e-13
Identities = 21/129 (16%), Positives = 44/129 (34%), Gaps = 12/129 (9%)

Query: 7 PKGIAEQATEKAAEQNVRVALIRAANQCFTASDYDSVSIRKIAQQAGVNMAMIRYYFGNK 66
+ ++A E R ++ A + F+ S S+ +IA+ AGV I ++F +K
Sbjct: 2 ARKTKQEAQET------RQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDK 55

Query: 67 LGLFEAMVTEQIHPIHQRAKTLQKHQAK---PTIADLINEFYQTMIPNPDFPRF---LFR 120
LF + I + Q + +++ ++ + +F
Sbjct: 56 SDLFSEIWELSESNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFH 115

Query: 121 LMNSDGSSE 129
G
Sbjct: 116 KCEFVGEMA 124


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1562RTXTOXIND545e-10 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 54.4 bits (131), Expect = 5e-10
Identities = 56/289 (19%), Positives = 100/289 (34%), Gaps = 60/289 (20%)

Query: 110 RLAQAQADRKALEGQIEGKKLQLENLKLSLEIENNRYDLVKSDLKRKETLRKQNLISQSE 169
+ + Q + E ++ K+ + + + N + KS L +L + I+
Sbjct: 194 QFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSRVEKSRLDDFSSLLHKQAIA--- 250

Query: 170 LDGERQNLLAQQQKLQELDNSLN-----LMPNETQILQA-----------------QLLQ 207
+ +L Q+ K E N L L E++IL A +L Q
Sbjct: 251 ----KHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLRQ 306

Query: 208 AIAREQEAQSQLTK-------TEIRLPFEGRVAEVNV--EGSQVVSPQQVLARINGIEVM 258
+L K + IR P +V ++ V EG V + + ++ + + +
Sbjct: 307 TTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTTAETLMVIVPEDDTL 366

Query: 259 EVEAQVSLGDVMTLMKTVNRPQGQDKQLPRAEALGLTAEITLKGATYSF--SWPAEITRI 316
EV A V D+ G A I ++ Y+ ++ I
Sbjct: 367 EVTALVQNKDI-------------GFINV-----GQNAIIKVEAFPYTRYGYLVGKVKNI 408

Query: 317 G--ETVDPTLATVNIVLQVEQQYRELKIGQSPPLVNGMFVSARIKGGER 363
D L V V+ ++ ++ PL +GM V+A IK G R
Sbjct: 409 NLDAIEDQRLGLVFNVIISIEENCLSTGNKNIPLSSGMAVTAEIKTGMR 457


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1563ACRIFLAVINRP447e-142 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 447 bits (1152), Expect = e-142
Identities = 216/1051 (20%), Positives = 439/1051 (41%), Gaps = 55/1051 (5%)

Query: 1 MIGFFVRHPTATSLLMLAFIVLGIKALPELKRETFPEFSKSYITAQVVLPGASPQDVEEN 60
M FF+R P +L + ++ G A+ +L +P + ++ PGA Q V++
Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60

Query: 61 LCLRMEDAVDSLGSIIETKCDAL-EGVARMTLKLDDKADLSRSLVDVQTKISAIKD-FPA 118
+ +E ++ + +++ + G +TL D + V VQ K+ P
Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120

Query: 119 EIEPPIVEELDFNERII----DIAVSASTSKPELKAYAED-LKRRLKLDTSISQVEISGF 173
E++ + + + ++ + T++ ++ Y +K L + V++ G
Sbjct: 121 EVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFG- 179

Query: 174 SSHQLLVEVSLGAIKRLGMSVADVAKQIEQQNVQLPSGTVETPSK------NILIRFDQR 227
+ + + + + + + ++ DV Q++ QN Q+ +G + N I R
Sbjct: 180 AQYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTR 239

Query: 228 EVEPERLANIVIRSDAQGGVVRLRDIATITDRFELDEESIRFDGEQAAILTVFKNKSQDS 287
PE + +R ++ G VVRL+D+A + E R +G+ AA L + ++
Sbjct: 240 FKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANA 299

Query: 288 LRLKEEIIGFLDAEKLRTPNGITISTSNDLSSLLWDRLTMLVKNGWQGVVLVFLCMWLF- 346
L + I L + P G+ + D + + + +VK ++ ++LVFL M+LF
Sbjct: 300 LDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFL 359

Query: 347 FSLRYSFWVAMGLPVAFMGSLFFMAQLGLTINIMTLVAFLMAIGIMMDDAIVIAESIA-A 405
++R + + +PV +G+ +A G +IN +T+ ++AIG+++DDAIV+ E++
Sbjct: 360 QNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERV 419

Query: 406 HIERGMNKADAVIQGVKRVLPGVVSSFLTTVFIFSSIAFMEGDMGKVLRVIPQTLLLILT 465
+E + +A + + ++ +V + +F +AF G G + R T++ +
Sbjct: 420 MMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMA 479

Query: 466 VSLVEAFLILPNHLAHAAKGKERKTSRFKQAFNQKFE---YFRTVQLVAAVEWVINWRYV 522
+S++ A ++ P A K + K F F +V ++
Sbjct: 480 LSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGR 539

Query: 523 FMGSMVSLLFISISLAAGGAIKFVGFPELDGDVAEARIILPPGSTLEQTELVVNRIVSVA 582
++ ++ + L F PE D V I LP G+T E+T+ V++++
Sbjct: 540 YLLIYALIVAGMVVLFLRLPSSF--LPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYY 597

Query: 583 KALDAKYSDKEDGQRLVQHITERFNFNADAGESGAHVATVKIDLLSAEVRQTLMSTFI-R 641
+ V+ + F+ A +A V + + +
Sbjct: 598 LKNEKA---------NVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIH 648

Query: 642 EWQQGVGEMVDPIAIVFKQPK---MGPAGRA--IEIRVRGDNLDQLKSASIEV-QQYLQG 695
+ +G++ D I F P +G A I G D L A ++ Q
Sbjct: 649 RAKMELGKIRDGFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQH 708

Query: 696 FNGVSGVMDSMRPGKAEILMTLKPG-AEAFGVN----GMMLASQLRGAYFHQTADNIQVG 750
+ V + A+ + + A+A GV+ +++ L G Y +
Sbjct: 709 PASLVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVND----FIDR 764

Query: 751 PESIQIDVQLDKADAAKLENLANFPISIGSAGEQVPLSAVANFEWQRGYVKISRLDGMRF 810
++ VQ D E++ + + GE VP SA W G ++ R +G+
Sbjct: 765 GRVKKLYVQADAKFRMLPEDVDKLYVRS-ANGEMVPFSAFTTSHWVYGSPRLERYNGLPS 823

Query: 811 VTITGEVDTHLANASEINNAFKDELLPELKQRYP-GIRVSYEGEVKESKTTQNSMASGFI 869
+ I GE A ++ L+ L + P GI + G + + + N +
Sbjct: 824 MEIQGEA------APGTSSGDAMALMENLASKLPAGIGYDWTGMSYQERLSGNQAPALVA 877

Query: 870 VGLLAVFAILSLQFKSYIEPLVVMAVIPLGLIGVLWGHLLLGYSMSMPSILGFVALAGVV 929
+ + VF L+ ++S+ P+ VM V+PLG++GVL L + ++G + G+
Sbjct: 878 ISFVVVFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLS 937

Query: 930 VNDSILLVQYIR-YHVEEGQSVHQAVVSASKERFRAVFITSLTTAAGMLPLLLETSIQAQ 988
++IL+V++ + +EG+ V +A + A + R R + +TSL G+LPL + +
Sbjct: 938 AKNAILIVEFAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSG 997

Query: 989 VLQPLVVSMVFGIFASTALVLFMVPACYAIL 1019
+ + ++ G+ ++T L +F VP + ++
Sbjct: 998 AQNAVGIGVMGGMVSATLLAIFFVPVFFVVI 1028


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1564ANTHRAXTOXNA280.048 Anthrax toxin LF subunit signature.
		>ANTHRAXTOXNA#Anthrax toxin LF subunit signature.

Length = 800

Score = 28.2 bits (62), Expect = 0.048
Identities = 11/40 (27%), Positives = 24/40 (60%)

Query: 230 LVVIRTISDKADGSAHLVYEEAKQVTADNSVAITLNMLSQ 269
L +I+++SD +D S L ++ K+ N+ +I +N + +
Sbjct: 193 LNLIKSLSDDSDSSDLLFSQKFKEKLELNNKSIDINFIKE 232


75Spea_1681Spea_1688N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_1681-211-0.760536TetR family transcriptional regulator
Spea_1682010-0.089622cysteine synthase A
Spea_1683011-0.270868RDD domain-containing protein
Spea_16840110.562366response regulator receiver modulated
Spea_1685-1110.762278hypothetical protein
Spea_16860100.546108putative sulfate transport protein CysZ
Spea_16870100.508734chromosome segregation protein SMC
Spea_1688-1110.309266cell division protein ZipA
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1681HTHTETR426e-07 TetR bacterial regulatory protein HTH signature.
		>HTHTETR#TetR bacterial regulatory protein HTH signature.

Length = 215

Score = 41.9 bits (98), Expect = 6e-07
Identities = 15/57 (26%), Positives = 26/57 (45%)

Query: 11 QSNRSDGQARRIEILEATLRLIVKEGIRGVRHRAVATEANVPLSSTTYYFNDIKDLI 67
+ + + Q R IL+ LRL ++G+ +A A V + ++F D DL
Sbjct: 3 RKTKQEAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLF 59


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1684HTHFIS652e-13 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 64.9 bits (158), Expect = 2e-13
Identities = 24/112 (21%), Positives = 48/112 (42%), Gaps = 3/112 (2%)

Query: 120 QSVKVLVADDSLVSRKFIRSLLEQHLFQVIEADDGISALETLNDNPDIKLLITDYNMPGL 179
+LVADD R + L + + V + + + L++TD MP
Sbjct: 2 TGATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGD-GDLVVTDVVMPDE 60

Query: 180 DGFGLIIKVREQFSREELVIIGLSSDSDESLSARFIKNGANDFLQKPFVHEE 231
+ F L+ ++++ ++++ + ++ A + GA D+L KPF E
Sbjct: 61 NAFDLLPRIKKARPDLPVLVMSAQNTFMTAIKA--SEKGAYDYLPKPFDLTE 110



Score = 53.7 bits (129), Expect = 5e-10
Identities = 20/116 (17%), Positives = 48/116 (41%), Gaps = 5/116 (4%)

Query: 2 RILVVEDSKTVSRVMRHLLTQELSCEVDVAPDMGSAKELLAQNEYFVAITDLNLPDAQEG 61
ILV +D + V+ L++ +V + + + +A + + +TD+ +PD
Sbjct: 5 TILVADDDAAIRTVLNQALSRA-GYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAF 63

Query: 62 EIVKFVLA--KQIPCIVLTGSWDAEQRERLLQLGIVDYVFKENRFSYEYTAKLVKR 115
+++ + +P +V++ + + G DY+ K F ++ R
Sbjct: 64 DLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKP--FDLTELIGIIGR 117


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1687RTXTOXIND482e-07 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 47.5 bits (113), Expect = 2e-07
Identities = 42/226 (18%), Positives = 88/226 (38%), Gaps = 17/226 (7%)

Query: 653 KGDMAPLVSQIQQKLQFIQTQQIQLAALSSQLRSQQQSVTQTVSRLAKVEQELNEAQQEL 712
KGD+ ++ + + ++TQ L A Q R Q S + +++L +++ Q +
Sbjct: 120 KGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNV 179

Query: 713 QALQLSVELRVQQQQHFSEALEKAQAAKTDGQALKAQALEKVTQLKPLRQQLDAQVAQTA 772
++ + ++Q + +K Q + +K + + +++ +
Sbjct: 180 SEEEVLRLTSLIKEQFSTWQNQKYQ--------KELNLDKKRAERLTVLARINRYENLSR 231

Query: 773 ASEQSLHTQMMLIEQQVNQHQQRLLELEQSQTVLKLQLEAKDNALQEGESQPLKDQLEQA 832
+ L L+ +Q + +LE E +L + L++ ES+ L + E
Sbjct: 232 VEKSRLDDFSSLLHKQAIA-KHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQ 290

Query: 833 LQAQQLKQDALTALRLEQAELQELCDSAGTNKKQQLAKLEDLTQSS 878
L Q K + L LR + L +LAK E+ Q+S
Sbjct: 291 LVTQLFKNEILDKLRQTTDNIGLL--------TLELAKNEERQQAS 328



Score = 39.4 bits (92), Expect = 7e-05
Identities = 24/208 (11%), Positives = 65/208 (31%), Gaps = 11/208 (5%)

Query: 606 VGVDFVIEKTQAAGSIVELKNEQI-ALQESVDLNQSALVKLSETLVSLKGDMAPLVSQIQ 664
+G + KTQ++ L+ + L S++LN+ +KL + ++
Sbjct: 130 LGAEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTS 189

Query: 665 QKLQFIQTQQIQLAALSSQLRSQQQSVTQTVSRLAKVEQELNEAQQELQALQLSVELRVQ 724
+ T Q Q L ++ ++R+ + E + L + +
Sbjct: 190 LIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSRVEKSRLDDFSSLLHKQAI 249

Query: 725 QQQHFSEALEKAQAAKTDGQALKAQALEKVTQLKPLRQQLDAQVAQTAASEQSLHTQMML 784
+ A+ + + + ++ Q++ + ++
Sbjct: 250 AKH----AVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKN------E 299

Query: 785 IEQQVNQHQQRLLELEQSQTVLKLQLEA 812
I ++ Q + L + + +A
Sbjct: 300 ILDKLRQTTDNIGLLTLELAKNEERQQA 327


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1688TONBPROTEIN330.001 Gram-negative bacterial tonB protein signature.
		>TONBPROTEIN#Gram-negative bacterial tonB protein signature.

Length = 239

Score = 33.0 bits (75), Expect = 0.001
Identities = 17/55 (30%), Positives = 24/55 (43%)

Query: 140 PVITEQAVRTEPEPRLQPVFKPEPQLEPVELKPDPIVEPAPKQEQTEELGEPRDV 194
V EPEP +P+ +P + V KP P +P PK + + RDV
Sbjct: 60 AVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKPKPKPKPVKKVQEQPKRDV 114



Score = 31.9 bits (72), Expect = 0.003
Identities = 13/51 (25%), Positives = 21/51 (41%)

Query: 134 EISVAAPVITEQAVRTEPEPRLQPVFKPEPQLEPVELKPDPIVEPAPKQEQ 184
+++ P E +P P +PEP+ P K P+V PK +
Sbjct: 46 SVTMVTPADLEPPQAVQPPPEPVVEPEPEPEPIPEPPKEAPVVIEKPKPKP 96


76Spea_1729Spea_1736N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_17291160.908081acriflavin resistance protein
Spea_1730014-0.682173RND family efflux transporter MFP subunit
Spea_1731115-1.287742hypothetical protein
Spea_1732014-0.872076radical SAM domain-containing protein
Spea_1733014-0.335210two component LuxR family transcriptional
Spea_17340150.844534histidine kinase
Spea_17350171.680236sulfatase
Spea_17361211.704227ATPase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1729ACRIFLAVINRP428e-135 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 428 bits (1103), Expect = e-135
Identities = 218/1053 (20%), Positives = 423/1053 (40%), Gaps = 66/1053 (6%)

Query: 23 IAGYSMRNSVVSWLIIMVLAIGGILAFNDLGRLEDPEFTPRSALIVTAYPGASPEQVEEE 82
+A + +R + +W++ ++L + G LA L + P P + + YPGA + V++
Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60

Query: 83 VTLLIESALQQLPSVKWIKSVST-AGLSQVDVMMESEYTSLHLPQIWDEVRRKIGDLRT- 140
VT +IE + + ++ ++ S S AG + + +S T + Q +V+ K+
Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSG-TDPDIAQ--VQVQNKLQLATPL 117

Query: 141 LPPGASKP-IVNDDFGDVYGMIWGITGDG--YEMAELEQFAD-QLRRDVVTLEGVSKVMI 196
LP + I + Y M+ G D ++ + ++ + L GV V +
Sbjct: 118 LPQEVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQL 177

Query: 197 GGIQQQQVFVEISNSKIAALNIPIDHITALLQQQNTVSNAGRV------RIQDDTVRLFP 250
G Q + + + + + + L+ QN AG++ Q +
Sbjct: 178 FG-AQYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIA 236

Query: 251 TGEFQDISELRDLVISPVGASARILLGDVAEIRRGYVEVPTKLMSMNGLPALEFGVSFMP 310
F++ E + + + + L DVA + G E + +NG PA G+
Sbjct: 237 QTRFKNPEEFGKVTLRVNSDGSVVRLKDVARVELG-GENYNVIARINGKPAAGLGIKLAT 295

Query: 311 GENVIEVGARVQAHIDSMLNKQPVGIEMENIYNQPTQVEKAVDGFVWSLIEAVAIVIGVL 370
G N ++ ++A + + P G+++ Y+ V+ ++ V +L EA+ +V V+
Sbjct: 296 GANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVM 355

Query: 371 LLTMG-LKSGIIIGIVLILSVTGTFIFMEQMGIDLQRISLGALIIALGMLVDNAIVVVEG 429
L + +++ +I I + + + GTF + G + +++ +++A+G+LVD+AIVVVE
Sbjct: 356 YLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVEN 415

Query: 430 ILIGMQRGKSRFRAAI-DIVEQTKWPLLGATVIAVTAFAPIGLSEDISGELVGSLFWVVL 488
+ M K + A + Q + L+G ++ F P+ +G + ++
Sbjct: 416 VERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIV 475

Query: 489 ISLTLSWITAITTTPFLAAIFFKNTKPATEGEEVDPYKGV-------IFTSYRKFLKICI 541
++ LS + A+ TP L A K A E + G Y + +
Sbjct: 476 SAMALSVLVALILTPALCATLLK-PVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKIL 534

Query: 542 RRRKTTMLVLLVLLLGSVKGFGMLKNEFFPPMNLPKFMVDTWLPYSTDIRATAEEIQAME 601
+L+ +++ G V F L + F P + F+ LP T + + +
Sbjct: 535 GSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVT 594

Query: 602 QLVLSH--PEVTQVASSVGGGHVRFMLAYKPEKMYNNYGNLMVTIKDMDKLT----DVMT 655
L + V V + G N G V++K ++
Sbjct: 595 DYYLKNEKANVESVFTVNGFS---------FSGQAQNAGMAFVSLKPWEERNGDENSAEA 645

Query: 656 DVRALLEDNFAGANYNFKRFEMGPAPDGRIEARFQ-------GPDPEVLRDLSNQAKAIM 708
+ + + F M + F G + L NQ +
Sbjct: 646 VIHRAKMELGKIRDGFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMA 705

Query: 709 ARHEGA-TAVRDDWRERTKVIRPDFNVEAARNLGISKSQVDSALLANFSGRSVGLYREGS 767
A+H + +VR + E T + + + E A+ LG+S S ++ + G V + +
Sbjct: 706 AQHPASLVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRG 765

Query: 768 DLMPIIVQPPEAERTDINGIMEIQVWSHQLQSYVSLSQVVHSFDVEFEDPIIMRRDRKRT 827
+ + VQ R + ++ V S + V S + + P + R +
Sbjct: 766 RVKKLYVQADAKFRMLPEDVDKLYVRSANGEM-VPFSAFT-TSHWVYGSPRLERYNGLP- 822

Query: 828 VMVMTDEDQMGDLTTAAVLQSFKAEVESI--ELPEGYTMPWGGKHETSVDALVALGEKLS 885
M + E G + A+ A +E++ +LP G W G + ++
Sbjct: 823 SMEIQGEAAPGTSSGDAM-----ALMENLASKLPAGIGYDWTGMSYQERLSGNQAPALVA 877

Query: 886 GGYLVMILITILLFSSFKDAAVIWTVVPFAIIGVVVGLYSANMPFTFLALLGTMSLTGML 945
++V+ L L+ S+ + VVP I+GV++ N ++G ++ G+
Sbjct: 878 ISFVVVFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLS 937

Query: 946 IKNAIVLVEEIK-LQIKEGKEDYAAVIDASVSRVRPVSMAAVTTVLGMIPLITD-----G 999
KNAI++VE K L KEGK A + A R+RP+ M ++ +LG++PL G
Sbjct: 938 AKNAILIVEFAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSG 997

Query: 1000 FFQAMAVAMMAGLTFATILTLIVIPVMYTMIHR 1032
A+ + +M G+ AT+L + +PV + +I R
Sbjct: 998 AQNAVGIGVMGGMVSATLLAIFFVPVFFVVIRR 1030


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1730RTXTOXIND362e-04 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 36.0 bits (83), Expect = 2e-04
Identities = 23/155 (14%), Positives = 46/155 (29%), Gaps = 26/155 (16%)

Query: 40 AKIATVVSAAGSVQRSFPAQVSANASTSLAFRVPGQITKRYVTEGKRVEAGTLIAELDPT 99
++ V +A G + S ++ + + V EG+ V G ++ +L
Sbjct: 78 GQVEIVATANGKLTHSGRSKEIKPIEN-------SIVKEIIVKEGESVRKGDVLLKLTAL 130

Query: 100 DFNIHLDDARAKHELAVAQHDRNTTL---------------VPKGLATKAEFDTSRAEML 144
++ A + R L +E + R L
Sbjct: 131 GAEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSL 190

Query: 145 MAKANLDRASQ----NLKYTKIYAPYDGVVAQIHS 175
+ + +Q L K A V+A+I+
Sbjct: 191 IKEQFSTWQNQKYQKELNLDKKRAERLTVLARINR 225



Score = 35.6 bits (82), Expect = 3e-04
Identities = 20/139 (14%), Positives = 47/139 (33%), Gaps = 20/139 (14%)

Query: 150 LDRASQNLKYTKIYAPYDGVVAQ--IHSEDHDHVAATQPIVEF-QNDKVSDIQFDLPEKL 206
L + + + + I AP V Q +H+E V + ++ D ++ + K
Sbjct: 318 LAKNEERQQASVIRAPVSVKVQQLKVHTEG-GVVTTAETLMVIVPEDDTLEVTALVQNKD 376

Query: 207 LKQFDPDKFSELSTQVILDSYPEK---PLTATFKEMRKSTSS---GALSFRVTLSVMAK- 259
+ + + + ++++P L K + L F V +S+
Sbjct: 377 IGFINVG----QNAIIKVEAFPYTRYGYLVGKVKNINLDAIEDQRLGLVFNVIISIEENC 432

Query: 260 -----DGMRVLPGMSAKVQ 273
+ + GM+ +
Sbjct: 433 LSTGNKNIPLSSGMAVTAE 451


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1733HTHFIS554e-11 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 54.8 bits (132), Expect = 4e-11
Identities = 26/129 (20%), Positives = 54/129 (41%), Gaps = 5/129 (3%)

Query: 15 PTIIIADDHQIVSEGIARLVEK-NYQVQSITTNAEELIQAAKQFQPDIIITDISMPGMQL 73
TI++ADD + + + + + Y V+ T+NA L + D+++TD+ MP
Sbjct: 4 ATILVADDDAAIRTVLNQALSRAGYDVRI-TSNAATLWRWIAAGDGDLVVTDVVMPDENA 62

Query: 74 NQTLGLLKRTCKEAKIICLTMHDEAEILQAAFEYGADGYIVKHQAGFELLQALETVLAGK 133
L +K+ + ++ ++ + A E GA Y+ K F+L + + +
Sbjct: 63 FDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPK---PFDLTELIGIIGRAL 119

Query: 134 QYVSAELQE 142
+
Sbjct: 120 AEPKRRPSK 128


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1734PF06580310.010 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 30.6 bits (69), Expect = 0.010
Identities = 11/69 (15%), Positives = 28/69 (40%), Gaps = 2/69 (2%)

Query: 323 LSICLNREGKFAKLTIEDNGKGMAQDALANSSSLGIESMLER-AALIGGTIDFTVGHHQC 381
+ + ++ L +E+ G ++ S+ G++++ ER L G + Q
Sbjct: 281 ILLKGTKDNGTVTLEVENTGSLALKNT-KESTGTGLQNVRERLQMLYGTEAQIKLSEKQG 339

Query: 382 GFSVKLVWP 390
+ ++ P
Sbjct: 340 KVNAMVLIP 348


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1736HTHFIS340.001 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 33.7 bits (77), Expect = 0.001
Identities = 32/154 (20%), Positives = 65/154 (42%), Gaps = 19/154 (12%)

Query: 16 NQQILGQ----EQVVKQLVIALLANGHVLIQGLPGLAKT---RAVNEMANEVNAKLNRIQ 68
++G+ +++ + L + + ++I G G K RA+++ N I
Sbjct: 136 GMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVARALHDYGKRRNGPFVAIN 195

Query: 69 FTPDMLPADITGSEVYSNQ----TQSISFKPGPVFSH----FLLADEINRAPAKVQSALL 120
+P D+ SE++ ++ T + + G F L DEI P Q+ LL
Sbjct: 196 MAA--IPRDLIESELFGHEKGAFTGAQTRSTG-RFEQAEGGTLFLDEIGDMPMDAQTRLL 252

Query: 121 ESMAEGQVSVAGISHPLP-ELFMVLATQNPIEQE 153
+ +G+ + G P+ ++ +V AT ++Q
Sbjct: 253 RVLQQGEYTTVGGRTPIRSDVRIVAATNKDLKQS 286


77Spea_1776Spea_1785N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_1776-2140.135838sigma-54 dependent trancsriptional regulator
Spea_1777-2120.264649hypothetical protein
Spea_1778-2130.175160hypothetical protein
Spea_1779-1151.209673acriflavin resistance protein
Spea_1780-1150.601249acriflavin resistance protein
Spea_17811240.465287RND family efflux transporter MFP subunit
Spea_17823260.558197citrate synthase I
Spea_17833211.065155type II citrate synthase
Spea_17843221.265968succinate dehydrogenase cytochrome b556 subunit
Spea_17853241.152449succinate dehydrogenase hydrophobic membrane
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1776HTHFIS365e-125 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 365 bits (939), Expect = e-125
Identities = 119/380 (31%), Positives = 190/380 (50%), Gaps = 36/380 (9%)

Query: 111 DYHHLPVDWNHLNQTLGHAYGMALLKQKEQKGCTEFGQKTPLLGDSRSINNLRSNITKVA 170
DY P D L +G A +A K++ K + PL+G S ++ + + ++
Sbjct: 100 DYLPKPFDLTELIGIIGRA--LAEPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVLARLM 157

Query: 171 TSDEAVLISGETGTGKGLCAHLIHNQSRRKIGPFITINCGALPQSLIHSELFGHEKGAFT 230
+D ++I+GE+GTGK L A +H+ +R+ GPF+ IN A+P+ LI SELFGHEKGAFT
Sbjct: 158 QTDLTLMITGESGTGKELVARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFT 217

Query: 231 GADKQYIGHIERANKGTLFLDEIGDLTLESQVNLLQFLEEHIIERLGGSRNIAIDCRIIF 290
GA + G E+A GTLFLDEIGD+ +++Q LL+ L++ +GG I D RI+
Sbjct: 218 GAQTRSTGRFEQAEGGTLFLDEIGDMPMDAQTRLLRVLQQGEYTTVGGRTPIRSDVRIVA 277

Query: 291 ASHVNLETAVEEGRFREDLYYRINILHLHAPSLRQHKEDIPLLANEYLNLFSPEHHK-YT 349
A++ +L+ ++ +G FREDLYYR+N++ L P LR EDIP L ++ E
Sbjct: 278 ATNKDLKQSINQGLFREDLYYRLNVVPLRLPPLRDRAEDIPDLVRHFVQQAEKEGLDVKR 337

Query: 350 LTPKALDTMLDYEWPGNVRELKNRIHRAIIMASSDQLTAADLGIKI-----------TNI 398
+AL+ M + WPGNVREL+N + R + D +T + ++
Sbjct: 338 FDQEALELMKAHPWPGNVRELENLVRRLTALYPQDVITREIIENELRSEIPDSPIEKAAA 397

Query: 399 NPDEHDVVDLAQHRVV----------------------IDTELLLDAIKRNNHNISAAAR 436
+ + + ++ L+L A+ N AA
Sbjct: 398 RSGSLSISQAVEENMRQYFASFGDALPPSGLYDRVLAEMEYPLILAALTATRGNQIKAAD 457

Query: 437 ELKISRTTFYRLIKKCKIKL 456
L ++R T + I++ + +
Sbjct: 458 LLGLNRNTLRKKIRELGVSV 477


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1779ACRIFLAVINRP487e-157 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 487 bits (1254), Expect = e-157
Identities = 211/1051 (20%), Positives = 444/1051 (42%), Gaps = 73/1051 (6%)

Query: 3 ITRFALARPVTTTMFFVAILLFGLASSRLLPLEMFPGIDIPQVIVEVPYKGSTPAEVERD 62
+ F + RP+ + + +++ G + LP+ +P I P V V Y G+ V+
Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60

Query: 63 ITNVLEESLATMGGIEELRSSSSQNG-AEIDLRMKWGQNVATKSLEAREKIDAVRHLLPK 121
+T V+E+++ + + + S+S G I L + G + ++ + K+ LLP+
Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120

Query: 122 DVERVFIRQFSTADMPVLNLRISSDRELSSAFDLLD---KQLKKPLERVEGVSQVTLYGV 178
+V++ I ++ ++ SD ++ D+ D +K L R+ GV V L+G
Sbjct: 121 EVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFG- 179

Query: 179 EQKQIEIRINADKLSASNISVQSLNRRLQQENFVINAGVLKTDSRV------YQVSPKGE 232
Q + I ++AD L+ ++ + +L+ +N I AG L + + +
Sbjct: 180 AQYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTR 239

Query: 233 FRNLDDITALVLAPG-----ITLGDIANVSFSLPERLDGRHLDQNYAVGLDVFKESGANL 287
F+N ++ + L + L D+A V ++ A GL + +GAN
Sbjct: 240 FKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANA 299

Query: 288 VDVSQRVMKVIDEAKRDSQFEGIKLFVMEDQAYGVTSSLRDLLTAGLIGALLSFVVLYLF 347
+D ++ + + E + +G+K+ D V S+ +++ +L F+V+YLF
Sbjct: 300 LDTAKAIKAKLAELQPFFP-QGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLF 358

Query: 348 LRDLKMTLVIVSSVPIAICMTLAAMYFLGYSLNILSMMGLLLAVGMLIDNAVVVTESVLQ 407
L++++ TL+ +VP+ + T A + GYS+N L+M G++LA+G+L+D+A+VV E+V +
Sbjct: 359 LQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVER 418

Query: 408 QKQAQIADGSVQEVGVAKINSSAILRGVDKVSLAVLAGTLTTAIVFLPNIFGVKVELTIF 467
A + + ++ A++ + + VF+P F I+
Sbjct: 419 VMMEDKLPP-----------KEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIY 467

Query: 468 LEHVAIAICISLAASLLVAKTLLPLMLSRMSFSQKKAPKK-------------SQLQARY 514
+ +I I ++A S+LVA L P + + + + Y
Sbjct: 468 RQ-FSITIVSAMALSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHY 526

Query: 515 QTSLNWILAHPRISGVLAIVILASTALPLSMVKQDQSDGEGNNRLYINYQVEGRHSLDVT 574
S+ IL ++ +I+A + + E Q+ + + T
Sbjct: 527 TNSVGKILGSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERT 586

Query: 575 EAMITRMETYLYAN--KDEFQIDSVYSYFAADRGQSTLIL-------------KEDTEVD 619
+ ++ ++ Y N + + +V + + + Q+ + + E
Sbjct: 587 QKVLDQVTDYYLKNEKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAV 646

Query: 620 MKALK---KTIREGFPKFAIAKPQFGWGGENNGVRVSLTGRSTT---ELIHLSEQVIPLL 673
+ K IR+GF P G G L ++ L Q++ +
Sbjct: 647 IHRAKMELGKIRDGF-VIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMA 705

Query: 674 S-NIDGLTDVRSELNGAQQEVVIRIDRQMAARLDLKLNEIASSISMALRGSPLRSFRHDP 732
+ + L VR + + +D++ A L + L++I +IS AL G+ + F D
Sbjct: 706 AQHPASLVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFI-DR 764

Query: 733 SGELRIEMAFEQQWRLSLEKLKQLPVIRIDNRVYTLDSLAKIEILPRFDTIRHYDRQTAL 792
++ + + ++R+ E + +L V + + + + + Y+ ++
Sbjct: 765 GRVKKLYVQADAKFRMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSM 824

Query: 793 SIGANLDE-LTTEEAQDKITQVMENINFPAGYGYSLRGGFQKQDEDEAVMATNMILAIAM 851
I ++ +A + + + PAG GY G ++ + ++ +
Sbjct: 825 EIQGEAAPGTSSGDAMALMENLASKL--PAGIGYDWTGMSYQERLSGNQAPALVAISFVV 882

Query: 852 IYIVMAALFESLLLPTAIITSILFSITGVFWALLFTGTPMSIMAMIGILILMGIVVNNGI 911
+++ +AAL+ES +P +++ + I GV A + M+G+L +G+ N I
Sbjct: 883 VFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAI 942

Query: 912 VLVDQINQLSPELDK-LSDTISAVCYTRLRPVLMTVGTTVLGLVPLAMGDTQLGGGGPSY 970
++V+ L + K + + RLRP+LMT +LG++PLA+ G G +
Sbjct: 943 LIVEFAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAIS---NGAGSGAQ 999

Query: 971 SPMAIAIIGGLTFSTVTSLYLVPLCYQALYR 1001
+ + I ++GG+ +T+ +++ VP+ + + R
Sbjct: 1000 NAVGIGVMGGMVSATLLAIFFVPVFFVVIRR 1030


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1780ACRIFLAVINRP6480.0 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 648 bits (1673), Expect = 0.0
Identities = 248/1100 (22%), Positives = 466/1100 (42%), Gaps = 96/1100 (8%)

Query: 3 IIKTAVNRPVTVWMFMFAVILFGMVGFSRLAVKLLPDLSYPTITIRTQYIGAAPVEVEQL 62
+ + RP+ W+ +++ G + +L V P ++ P +++ Y GA V+
Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60

Query: 63 VSKPIEEAAGIVKGLRKISSISRS-GMSDVVLEFEWGTDMDMASLDVREKLDTIE--LPL 119
V++ IE+ + L +SS S S G + L F+ GTD D+A + V+ KL LP
Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120

Query: 120 DVKKPLLLRFNPNLDPIVRLALSVPETSGSTSETMSETELKQMRTYAEEELKRQLESLTG 179
+V++ + + ++ S + ++ ++ Y +K L L G
Sbjct: 121 EVQQQGISVEKSSSSYLMVAGFV------SDNPGTTQDDI---SDYVASNVKDTLSRLNG 171

Query: 180 VAAVRLSGGLQQEVHIQLNQQKLTQLNLSADLIRSRIAEENINLSAGKVIQGDK------ 233
V V+L G Q + I L+ L + L+ + +++ +N ++AG++
Sbjct: 172 VGDVQLFGA-QYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQL 230

Query: 234 EYLVRTLNQFNSLDELGQIVIFRDEQ-TLVRLFEVAQIVDAFKERNDITRIGDKESIELA 292
+ +F + +E G++ + + ++VRL +VA++ + N I RI K + L
Sbjct: 231 NASIIAQTRFKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLG 290

Query: 293 IYKEGDANTVAVARKVTDELNKLNQHNPKA-ELKVIYDQSEFIESAVNEVTSAALIGSLL 351
I AN + A+ + +L +L P+ ++ YD + F++ +++EV +L
Sbjct: 291 IKLATGANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIML 350

Query: 352 SMLVIYLFLRDIIPTLIISISIPFSVIATFNMMYFADISLNIMSLGGIALAVGLLVDNAI 411
LV+YLFL+++ TLI +I++P ++ TF ++ S+N +++ G+ LA+GLLVD+AI
Sbjct: 351 VFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAI 410

Query: 412 VVLENIDRC-KSLGMNRLEAAVTGTKEVSGAIFASTLTTLAVFVPLVFVDGVAGALFSDQ 470
VV+EN++R + EA ++ GA+ + AVF+P+ F G GA++
Sbjct: 411 VVVENVERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQF 470

Query: 471 ALTVTFALLASLLVALTTIPMLASREGFKALPPLLEKTAKPKPETKLAKLKHYSATVFSF 530
++T+ A+ S+LVAL P L + LL+ + E K
Sbjct: 471 SITIVSAMALSVLVALILTPALCAT--------LLKPVSAEHHENK-------------- 508

Query: 531 PFVLLFNYLPSALLTLVLILGRTLSWLAGLVMRPISSAFNWGYHKLERFYHKLLAAALKF 590
G W FN + Y + L
Sbjct: 509 --------------------GGFFGW------------FNTTFDHSVNHYTNSVGKILGS 536

Query: 591 RVLTLAIALMVTASAALLVPRLGMELIPPMNQGEFYVEVLLPPGTEVSETDRVLRTLALS 650
L I ++ A +L RL +P +QG F + LP G T +VL +
Sbjct: 537 TGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDY 596

Query: 651 IKDRTDVKHAYSQAGSGGLMTSDTSRGGENWGRLQVVLQDHNAFDAVADKLRATAMRIPE 710
+ + + S G S ++ N G V L+ + + A R
Sbjct: 597 YL-KNEKANVESVFTVNGFSFSGQAQ---NAGMAFVSLKPWEERNGDENSAEAVIHRAKM 652

Query: 711 LEAKVQHPELFSFKTPLEIEL-------------VGYDLAQLKQTADNLVDALSDS-DRF 756
K++ + F P +EL G L Q + L+ +
Sbjct: 653 ELGKIRDGFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASL 712

Query: 757 ADINTSLRDGQPELSIRFDHERLAALGMDAPTVANRIAQRIGGTIASQYTVRDRKIDILV 816
+ + + + + D E+ ALG+ + I+ +GGT + + R R + V
Sbjct: 713 VSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYV 772

Query: 817 RSELDERNQISDIDSMIINPNSSHPISLSAVADVSLKLGPSAINRISQQRVAIVSANLAY 876
+++ R D+D + + + + SA G + R + + A
Sbjct: 773 QADAKFRMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAP 832

Query: 877 GDLNDAVLNAREILANQTLPTSIQARFGGQNEEMEHSFKSLQIALVLAVFLVYLVMASQF 936
G + + E LA++ LP I + G + + S + ++ +V+L +A+ +
Sbjct: 833 GTSSGDAMALMENLASK-LPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALY 891

Query: 937 ESLLHPLLILIAVPMAVGGSILGLFITQTHLSVVVFIGLIMLAGIVVNNAIVLVDRINQL 996
ES P+ +++ VP+ + G +L + V +GL+ G+ NAI++V+ L
Sbjct: 892 ESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAKDL 951

Query: 997 -RQDGEEKITAISNAAKSRLRPIIMTTMTTALGLSPMALGLGDGSEVRAPMAITVIFGLS 1055
++G+ + A A + RLRPI+MT++ LG+ P+A+ G GS + + I V+ G+
Sbjct: 952 MEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMV 1011

Query: 1056 LSTLLTLVVIPVLYALFDRK 1075
+TLL + +PV + + R
Sbjct: 1012 SATLLAIFFVPVFFVVIRRC 1031



Score = 109 bits (275), Expect = 2e-26
Identities = 96/522 (18%), Positives = 203/522 (38%), Gaps = 40/522 (7%)

Query: 587 ALKFRVLTLAIALMVTASAALLVPRLGMELIPPMNQGEFYVEVLLPPGTEVSETDRVLRT 646
++ + +A+++ + AL + +L + P + V P + D V +
Sbjct: 5 FIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDTVTQV 64

Query: 647 LALSIKDRTDVKHAYSQAGSGGLMT-SDTSRGGENWGRLQVVLQDHNAFDAVADKLRATA 705
+ ++ ++ + S + S G +T + T + G + + V +KL+
Sbjct: 65 IEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTD---PDIAQVQ------VQNKLQLAT 115

Query: 706 MRIPELEAKVQHPELFSFKTPLEIELV--------GYDLAQLKQTAD-NLVDALSDSDRF 756
+P+ +VQ + K+ +V G + N+ D LS +
Sbjct: 116 PLLPQ---EVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGV 172

Query: 757 ADINTSLRDGQPELSIRFDHERLAALGMDAPTVANRI----AQRIGGTIASQYTVRDRKI 812
D+ Q + I D + L + V N++ Q G + + +++
Sbjct: 173 GDVQLF--GAQYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQL 230

Query: 813 DILVRSELDERNQISDIDSMIINPNSS-HPISLSAVADVSLKLGPSAIN---RISQQRVA 868
+ + ++ +N + + + NS + L VA V +LG N RI+ + A
Sbjct: 231 NASIIAQTRFKN-PEEFGKVTLRVNSDGSVVRLKDVARV--ELGGENYNVIARINGKPAA 287

Query: 869 IVSANLAYGDLNDAVLNA-REILA--NQTLPTSIQA-RFGGQNEEMEHSFKSLQIALVLA 924
+ LA G A + LA P ++ ++ S + L A
Sbjct: 288 GLGIKLATGANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEA 347

Query: 925 VFLVYLVMASQFESLLHPLLILIAVPMAVGGSILGLFITQTHLSVVVFIGLIMLAGIVVN 984
+ LV+LVM +++ L+ IAVP+ + G+ L ++ + G+++ G++V+
Sbjct: 348 IMLVFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVD 407

Query: 985 NAIVLVDRINQ-LRQDGEEKITAISNAAKSRLRPIIMTTMTTALGLSPMALGLGDGSEVR 1043
+AIV+V+ + + + +D A + ++ M + PMA G +
Sbjct: 408 DAIVVVENVERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIY 467

Query: 1044 APMAITVIFGLSLSTLLTLVVIPVLYALFDRKEFERKQSDKN 1085
+IT++ ++LS L+ L++ P L A + +K
Sbjct: 468 RQFSITIVSAMALSVLVALILTPALCATLLKPVSAEHHENKG 509


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1781RTXTOXIND446e-07 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 44.0 bits (104), Expect = 6e-07
Identities = 40/192 (20%), Positives = 74/192 (38%), Gaps = 30/192 (15%)

Query: 117 DLDRSQAEVEIIEQELNRLKK--ISNKEFFSADSMAKL--------EYNLQAAMAKRDLA 166
+L ++++E IE E+ K+ + F + + KL L+ A +
Sbjct: 267 ELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEILDKLRQTTDNIGLLTLELAKNEERQQ 326

Query: 167 ALYVQESMIRSPIDGIVATRFVKS-GNMAKEFDELFYVVNQDELYGI-VHLPEQQLQHLR 224
A S+IR+P+ V V + G + + L +V +D+ + + + + +
Sbjct: 327 A-----SVIRAPVSVKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFIN 381

Query: 225 LGQDAEIYANKHIQQTTH---ASVLRISP--IVDSQSGTF--------KVTLSVPNQNAT 271
+GQ+A I V I+ I D + G + LS N+N
Sbjct: 382 VGQNAIIKVEAFPYTRYGYLVGKVKNINLDAIEDQRLGLVFNVIISIEENCLSTGNKNIP 441

Query: 272 LKAGMFTRVELK 283
L +GM E+K
Sbjct: 442 LSSGMAVTAEIK 453



Score = 42.9 bits (101), Expect = 1e-06
Identities = 19/117 (16%), Positives = 49/117 (41%), Gaps = 12/117 (10%)

Query: 80 KVVTRVAGLIRSIEVEEGDRVKKGQLLAVIDSKRQKFDLDRSQA------------EVEI 127
++ +++ I V+EG+ V+KG +L + + + D ++Q+ ++
Sbjct: 98 EIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILS 157

Query: 128 IEQELNRLKKISNKEFFSADSMAKLEYNLQAAMAKRDLAALYVQESMIRSPIDGIVA 184
ELN+L ++ + ++++ E ++ K + Q+ +D A
Sbjct: 158 RSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRA 214


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_1785TYPE3OMOPROT280.009 Type III secretion system outer membrane O protein ...
		>TYPE3OMOPROT#Type III secretion system outer membrane O protein

family signature.
Length = 303

Score = 27.7 bits (61), Expect = 0.009
Identities = 12/28 (42%), Positives = 16/28 (57%)

Query: 5 TNAASLGRSGVHDFILIRASAVVLACYT 32
T + LGR G+ D +LIR S + CY
Sbjct: 161 TQRSLLGRIGIGDVLLIRTSRAEVYCYA 188


78Spea_2173Spea_2183N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_2173-111-0.715047short-chain dehydrogenase/reductase SDR
Spea_2174-111-0.700924nuclear transport factor 2
Spea_2175-210-0.702601acyl-CoA dehydrogenase domain-containing
Spea_2176-29-0.420789acyl-CoA dehydrogenase domain-containing
Spea_2177-18-0.380295acriflavin resistance protein
Spea_2178-111-0.890802RND family efflux transporter MFP subunit
Spea_2179-111-1.349208SecC motif-containing protein
Spea_2180-110-1.470137putative manganese-dependent inorganic
Spea_2181-18-2.006892putative ATP-dependent protease La-likeprotein
Spea_2182-110-2.200544peptidase U32
Spea_2183-211-2.296816hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2173DHBDHDRGNASE1228e-36 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase sig...
		>DHBDHDRGNASE#2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

signature.
Length = 261

Score = 122 bits (306), Expect = 8e-36
Identities = 77/254 (30%), Positives = 125/254 (49%), Gaps = 13/254 (5%)

Query: 7 GKVALITGAARGVGLATARLMAREGAQVVLTDINAEQGKEIANSIGNNSLFIEH---DVT 63
GK+A ITGAA+G+G A AR +A +GA + D N E+ +++ +S+ + E DV
Sbjct: 8 GKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEKLEKVVSSLKAEARHAEAFPADVR 67

Query: 64 KEADWSAVINHIEAKFGQLNILLNNAAILQLGDIKEETLAGWQRVHMVNSDSVFLRIHYA 123
A + IE + G ++IL+N A +L+ G I + W+ VNS VF
Sbjct: 68 DSAAIDEITARIEREMGPIDILVNVAGVLRPGLIHSLSDEEWEATFSVNSTGVFNASRSV 127

Query: 124 LPLMEKSGGGSIINMSSSSAVFGMPHFAAYGASKAAIRGLSQSVAVYCSQTKNNVRCNTL 183
M GSI+ + S+ A AAY +SKAA ++ + + ++ N+RCN +
Sbjct: 128 SKYMMDRRSGSIVTVGSNPAGVPRTSMAAYASSKAAAVMFTKCLGLELAEY--NIRCNIV 185

Query: 184 HPDSIMTPMVMEI-SAQAGDRSLADPDRAK-------AYVCRPEDVANSVLFLASDESKH 235
P S T M + + + G + + +P D+A++VLFL S ++ H
Sbjct: 186 SPGSTETDMQWSLWADENGAEQVIKGSLETFKTGIPLKKLAKPSDIADAVLFLVSGQAGH 245

Query: 236 INGAAIALDGGATV 249
I + +DGGAT+
Sbjct: 246 ITMHNLCVDGGATL 259


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2177ACRIFLAVINRP430e-136 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 430 bits (1108), Expect = e-136
Identities = 204/1054 (19%), Positives = 420/1054 (39%), Gaps = 62/1054 (5%)

Query: 12 FARNSVAANLLMIIILLGGLLTANTIRKQFFPAVEINWLEFNAVYPGAAPQEVEEGITIK 71
F R + A +L II+++ G L + +P + + +A YPGA Q V++ +T
Sbjct: 5 FIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDTVTQV 64

Query: 72 IEEALESVQGLKRVITYSNRNVSSG-YFRVEDSYDPQVVLEEVKSEIDSI-SSFPDGMER 129
IE+ + + L + + S+ S + DP + +V++++ P +++
Sbjct: 65 IEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQEVQQ 124

Query: 130 PKVERIKLRQE-VMYMSLY---GDLSQRQLKDLGEK-IHDELLQLPLVNITDFYGGLGYE 184
+ K +M +Q + D + D L +L V +G Y
Sbjct: 125 QGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGA-QYA 183

Query: 185 IAIEVSKDRLREFGLSFNDVAEAVRGYSRNMSAGQIRAE------NGYINLRVQNQAYVG 238
+ I + D L ++ L+ DV ++ + ++AGQ+ ++ Q +
Sbjct: 184 MRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRFKNP 243

Query: 239 YEFESLPLITLEDGTTLLLGDVATVVDGFEQGIQYSKFNGMNSVTFFIGAANDQSLTDVA 298
EF + L DG+ + L DVA V G E ++ NG + I A + D A
Sbjct: 244 EEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANALDTA 303

Query: 299 DVVKGYIAEKQKVLPQGVKLEPWVDMTYYLEGRLNLMLDSMKSGAVLVFILLALFLR-VR 357
+K +AE Q PQG+K+ D T +++ ++ ++ ++ +LVF+++ LFL+ +R
Sbjct: 304 KAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQNMR 363

Query: 358 LAFWVMMGLPVCFLGTLLFMPMGMIDVTINVISLFAFILVLGIVVDDAIVMGESAH-AEC 416
+ +PV LGT + +IN +++F +L +G++VDDAIV+ E+
Sbjct: 364 ATLIPTIAVPVVLLGTFAILA--AFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVMM 421

Query: 417 EEKGQTLDNVIRGVKRVAMPATFGVLTTIAAFLPITLDDGPSSAFGQAIGFVVILCLIFS 476
E+K + + + ++ + A F+P+ G + A + ++ + S
Sbjct: 422 EDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMALS 481

Query: 477 LIESKLILPAHLARMKQKTVVKPGSKNPLDWLRNGVNFLQGKVDAGLKILIHSYYRPTLE 536
++ + ++ PA A + +KP S + + D + +S +
Sbjct: 482 VLVALILTPALCATL-----LKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGK---- 532

Query: 537 LAVKYRYTVIMIFISMILVCAGLYSGGLVRFIGQPKIPHDF-PRI---TFEMNIDASENA 592
+ ++I+ ++ L+ ++P F P F I A
Sbjct: 533 -ILGSTGRYLLIYALIVAGMVVLF----------LRLPSSFLPEEDQGVFLTMIQLPAGA 581

Query: 593 TLSAALSIEEALRRVDNQLEEQYGQKMISDLQVELRGRTS----AQVMTKLVDPEIRPID 648
T + + + + E+ + + + G+ A V K + +
Sbjct: 582 TQERTQKVLDQVTDYYLKNEKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDEN 641

Query: 649 TFAVAELWRQNMPL--IPGMKSFTIQDNLFGGGRDDGDISFRLE---GKDDEQLIAAAKE 703
+ A A + R M L I F L G + L A +
Sbjct: 642 S-AEAVIHRAKMELGKIRDGFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQ 700

Query: 704 LKAKLNTLKG-VGDVNDSRQSSAKEIQFELK-PLAHSLGLTLADIARQVGNSFYGLEAQR 761
L + V + + + E+ A +LG++L+DI + + + G
Sbjct: 701 LLGMAAQHPASLVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVND 760

Query: 762 ILRNGEEIKVMLRYPEEQRNSIAQVSDVMIKTPQGAEIPLSEVAAIVVTDGVNSIRRENG 821
+ G K+ ++ + R V + +++ G +P S G + R NG
Sbjct: 761 FIDRGRVKKLYVQADAKFRMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNG 820

Query: 822 NRTINVWGSVDADQAEPFKLAKDIRDNFLPELLAKYPR-VKSEVSGNIQEQLDSADTQLR 880
++ + G + +A + L +K P + + +G ++ S +
Sbjct: 821 LPSMEIQGEAAPGTSSGDAMAL------MENLASKLPAGIGYDWTGMSYQERLSGNQAPA 874

Query: 881 DFLISMLVIYSLLAVPLKSYSQPIMIMSVIPFGVIGSVLGHMLLGLDLSALSVFGIIAAA 940
IS +V++ LA +S+S P+ +M V+P G++G +L L + G++
Sbjct: 875 LVAISFVVVFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTI 934

Query: 941 GVVVNDSLVMVDYINKSRE-SGVAMKLSVLEAGCRRFRAILLTSLTTFIGLVPIMTETSM 999
G+ +++++V++ E G + + L A R R IL+TSL +G++P+
Sbjct: 935 GLSAKNAILIVEFAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGA 994

Query: 1000 QAQMVIPMAVSLAFGVLFATVVTLVLIPCLYVMI 1033
+ + + + G++ AT++ + +P +V+I
Sbjct: 995 GSGAQNAVGIGVMGGMVSATLLAIFFVPVFFVVI 1028


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2178RTXTOXIND417e-06 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 41.0 bits (96), Expect = 7e-06
Identities = 28/154 (18%), Positives = 55/154 (35%), Gaps = 26/154 (16%)

Query: 52 PMSFAVSSYGVVNAKYETELVSQLNGEIVFLSEKFVR-GGFVKKGDILAKIDPSDYESAL 110
+ ++ G + ++ + + IV E V+ G V+KGD+L K+ E+
Sbjct: 79 QVEIVATANGKLTHSGRSKEIKPIENSIV--KEIIVKEGESVRKGDVLLKLTALGAEADT 136

Query: 111 IDAQANMASARA--------------------TLVQEKAYGKVAEEEWKRIKNGVPTELS 150
+ Q+++ AR L E + V+EEE R+ + + + S
Sbjct: 137 LKTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFS 196

Query: 151 LRKPQLAQ---EIAKLNSSEAGLKRAKRNLERTL 181
+ Q Q + K + + E
Sbjct: 197 TWQNQKYQKELNLDKKRAERLTVLARINRYENLS 230



Score = 40.6 bits (95), Expect = 9e-06
Identities = 20/124 (16%), Positives = 49/124 (39%), Gaps = 7/124 (5%)

Query: 105 DYESALIDAQANMASARATLVQEKAYGKVAEEEWKRIKNGVPTELSLRKPQLAQEIAKLN 164
+ E+ ++A + ++ L Q ++ A+EE++ + E+ +L Q +
Sbjct: 256 EQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQLFKNEIL---DKLRQTTDNIG 312

Query: 165 SSEAGLKRAKRNLERTLIKAPYDALIEARNI-GLGSYVSMGTPLGKVL---STAEAEIRL 220
L + + + ++I+AP ++ + G V+ L ++ T E +
Sbjct: 313 LLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALV 372

Query: 221 PIAD 224
D
Sbjct: 373 QNKD 376


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2179SECA532e-11 SecA protein signature.
		>SECA#SecA protein signature.

Length = 901

Score = 52.6 bits (126), Expect = 2e-11
Identities = 23/109 (21%), Positives = 43/109 (39%), Gaps = 11/109 (10%)

Query: 9 GRKTPKPKHESYGYNTKREIKVGTEEN------PLQLLVQTAEREAEVLQLLTDNELVGL 62
+K PK +++ ++ + + +Q+ + E E + + L +
Sbjct: 795 AQKDPKQEYKRESFSMFAAMLESLKYEVISTLSKVQVRMPEEVEELEQQRRMEAERLAQM 854

Query: 63 ITVDPNQEENILLLTGLLNKPQTTRFEKSPNRNDPCVCGSGKKYKKCCG 111
+ +++ E+ RNDPC CGSGKKYK+C G
Sbjct: 855 QQLSHQDDDS-----AAAAALAAQTGERKVGRNDPCPCGSGKKYKQCHG 898


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2181IGASERPTASE300.035 IgA-specific serine endopeptidase (S6) signature.
		>IGASERPTASE#IgA-specific serine endopeptidase (S6) signature.

Length = 1541

Score = 30.4 bits (68), Expect = 0.035
Identities = 32/179 (17%), Positives = 57/179 (31%), Gaps = 16/179 (8%)

Query: 165 EEAKRNSVGLSISAQGNYELVALNGEEPHTEESYVALSAQEQERMQNAISALEAQLRGIV 224
E +K+ S + + Q E A N E +S V + Q E Q+ E Q
Sbjct: 1042 ENSKQESKTVEKNEQDATETTAQNREVAKEAKSNVKANTQTNEVAQSGSETKETQTTETK 1101

Query: 225 RQITVWEEEYSEKQQKHDEQVAEEVLTHALASLKQQYKEQTNVKSYIKAMHKDILDNLDI 284
TV +E EK + E+ E + S KQ+ E ++ + ++ +
Sbjct: 1102 ETATVEKE---EKAKVETEKTQEVPKVTSQVSPKQEQSETVQPQAEPARENDPTVNIKEP 1158

Query: 285 FLEESEEQAALAYASMSKKMPR-------------RYQINVLVSQESQLQPIIVEETPN 330
+ + A + N + + QP + E+ N
Sbjct: 1159 QSQTNTTADTEQPAKETSSNVEQPVTESTTVNTGNSVVENPENTTPATTQPTVNSESSN 1217


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2183FbpA_PF05833290.039 Fibronectin-binding protein
		>FbpA_PF05833#Fibronectin-binding protein

Length = 577

Score = 28.7 bits (64), Expect = 0.039
Identities = 29/181 (16%), Positives = 58/181 (32%), Gaps = 16/181 (8%)

Query: 120 QSKVNAFNMQIDAIDKQIELNNVAAEKYIQMERIATGVTRIQKENNKLREQQQQLAMQRD 179
K+N F+ D I+ + N++ I +I TGV++ R + + +
Sbjct: 168 SPKLNPFDFSYDMIENFTKENSLQLNDNI-FSKIFTGVSKTLSSEICFRLKNNSIDLSLS 226

Query: 180 SVPVVSQGSIVGLIESLALSLNIKAETAQLGLVVFLSILLDFFAAF----FVGLIGEENR 235
++ + + E + T V F + L + +
Sbjct: 227 NLKEIVEVCKDLFKEIQSNKFEFNCYTKNNSFVGFYCLNLMSKEDYKKIQYDSSSKLLEN 286

Query: 236 F------RQRFKQQSQQLEPITLDAYRRLHNDDSDFIPIFEPKQLPEAEPKPLYERVLDA 289
F R K +S L+ I ++ R D L + E K +++ +
Sbjct: 287 FYYAKDKSDRLKSKSSDLQKIVMNNINRCTKKDKILN-----NTLKKCEDKDIFKLYGEL 341

Query: 290 L 290
L
Sbjct: 342 L 342


79Spea_2190Spea_2193N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_21900151.007596EmrB/QacA family drug resistance transporter
Spea_21910160.767610secretion protein HlyD family protein
Spea_2192-115-1.650231RND family efflux transporter MFP subunit
Spea_2193-115-1.704617hydrophobe/amphiphile efflux-1 (HAE1) family
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2190TCRTETB941e-22 Tetracycline resistance protein TetB signature.
		>TCRTETB#Tetracycline resistance protein TetB signature.

Length = 458

Score = 93.8 bits (233), Expect = 1e-22
Identities = 76/390 (19%), Positives = 156/390 (40%), Gaps = 16/390 (4%)

Query: 38 LDMTIANVALPHMMGALGVTSDQVTWVLTSYSMAEAIFIPLASFLALKFGIRNLLLISVS 97
L+ + NV+LP + WV T++ + +I + L+ + GI+ LLL +
Sbjct: 28 LNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVYGKLSDQLGIKRLLLFGII 87

Query: 98 GFIVSSALCGQADTITEMVTF-RVMQGAFGASVIPLSQSIMVQIYPANQRGKAMALFSVG 156
S + + ++ R +QGA A+ L ++ + P RGKA L
Sbjct: 88 INCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVARYIPKENRGKAFGLIGSI 147

Query: 157 VLLGPILGPTLGGIITENMDWRWIFYVNLPVGAICLTLIYTFVKLSGKGKPKIDWPIVIA 216
V +G +GP +GG+I + W ++ + + L+ +K + K D +I
Sbjct: 148 VAMGEGVGPAIGGMIAHYIHWSYLLLIPMITIITVPFLMK-LLKKEVRIKGHFDIKGIIL 206

Query: 217 MTIGIGLLQMVLDRGNQESWFESNTILFSTIISAIAIIFFVARSFTTKSEIAPVWLLRDR 276
M++GI + S +I F I+S ++ + FV L ++
Sbjct: 207 MSVGIVFFMLFTT---------SYSISF-LIVSVLSFLIFVKHIRKVTDPFVDPGLGKNI 256

Query: 277 NLAMSCLVMAGFSMG-MFGITQLQPMMLEQLLNY-PVETTGFAMAPRGLASAFVLLMMAR 334
M ++ G G + G + P M++ + E + P ++ +
Sbjct: 257 PF-MIGVLCGGIIFGTVAGFVSMVPYMMKDVHQLSTAEIGSVIIFPGTMSVIIFGYIGGI 315

Query: 335 YMDRIDARLLIVIGLSLNALGTYLMTQYSLEINIYWILLPSIIQGAGMGLVFAPLSQLAY 394
+DR ++ IG++ ++ +L + LE +++ + + G+ +S +
Sbjct: 316 LVDRRGPLYVLNIGVTFLSVS-FLTASFLLETTSWFMTIIIVFVLGGLSFTKTVISTIVS 374

Query: 395 ATLAPKDTIGGAVVFNLCRTIGGSFGISIV 424
++L ++ G + N + GI+IV
Sbjct: 375 SSLKQQEAGAGMSLLNFTSFLSEGTGIAIV 404


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2191RTXTOXIND693e-15 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 69.5 bits (170), Expect = 3e-15
Identities = 47/290 (16%), Positives = 92/290 (31%), Gaps = 41/290 (14%)

Query: 80 QEVSQGDLLVQIDPAPFQAQLDEARAAYEVAIQNNAASDDAILAASANVRSAVAQLTDAQ 139
+EV + L++ + +Q Q + + I R ++L D
Sbjct: 182 EEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENLSRVEKSRLDD-- 239

Query: 140 ATYQRIKQLVAKQLLPAQQLDDARAKLSSAEENVIAARATMSQLIK------------TQ 187
L+ KQ + + + K A + ++ + Q+ TQ
Sbjct: 240 -----FSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEYQLVTQ 294

Query: 188 GAQGNAAPEVKKAAAALSQ-------ASLSLSYTNIFAPKSGTLGKLTAHA-GSVVSVGQ 239
+ ++++ + + I AP S + +L H G VV+ +
Sbjct: 295 LFKNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTTAE 354

Query: 240 ALVPLV-EANTYWVQANFKETQLELITKGMQATITLDLYPSVDYH---GTIEAISPASGS 295
L+ +V E +T V A + + I G A I ++ +P Y G ++ I+ +
Sbjct: 355 TLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNINLDA-- 412

Query: 296 SFSLLPPENATGNWVKVPQRFPILIRLANESEHPDTPLRVGASANVTIDT 345
+ G V + PL G + I T
Sbjct: 413 -----IEDQRLGLVFNVIISIEENCLSTGN---KNIPLSSGMAVTAEIKT 454



Score = 43.7 bits (103), Expect = 7e-07
Identities = 16/116 (13%), Positives = 41/116 (35%)

Query: 63 IAPQVHGKVISVNASDYQEVSQGDLLVQIDPAPFQAQLDEARAAYEVAIQNNAASDDAIL 122
I P + V + + + V +GD+L+++ +A + +++ A
Sbjct: 99 IKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSR 158

Query: 123 AASANVRSAVAQLTDAQATYQRIKQLVAKQLLPAQQLDDARAKLSSAEENVIAARA 178
+ N + + ++++ L +Q + + E N+ RA
Sbjct: 159 SIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRA 214


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2192RTXTOXIND423e-06 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 42.1 bits (99), Expect = 3e-06
Identities = 24/112 (21%), Positives = 49/112 (43%), Gaps = 4/112 (3%)

Query: 102 VNRLSANVESQQSALEKAQRDVERLKPLYEQDAASQLDFDNALSVLSQAKSSVAASKAEL 161
+ +S LE+ + ++ K Y+ +QL + L L Q ++ EL
Sbjct: 261 YVEAVNELRVYKSQLEQIESEILSAKEEYQL--VTQLFKNEILDKLRQTTDNIGLLTLEL 318

Query: 162 EEARLELSYTEIQSPISGLVSRSEV-DIGALVGSSGQSLLTRVKQVDPIYVT 212
+ + I++P+S V + +V G +V + ++L+ V + D + VT
Sbjct: 319 AKNEERQQASVIRAPVSVKVQQLKVHTEGGVVT-TAETLMVIVPEDDTLEVT 369


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2193ACRIFLAVINRP9410.0 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 941 bits (2434), Expect = 0.0
Identities = 422/1028 (41%), Positives = 631/1028 (61%), Gaps = 9/1028 (0%)

Query: 1 MAQYFVNRPVFASVISIVIVLLGLIAMFQLPIDQYPYITPPQVKISASYPGATSTTAAES 60
MA +F+ RP+FA V++I++++ G +A+ QLP+ QYP I PP V +SA+YPGA + T ++
Sbjct: 1 MANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDT 60

Query: 61 VATPLEQELNGLPNMIYMSSKSTNSGSTNITITFDVGTNPDLAAVDAQNSTQQATGSLPI 120
V +EQ +NG+ N++YMSS S ++GS IT+TF GT+PD+A V QN Q AT LP
Sbjct: 61 VTQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQ 120

Query: 121 DVQTEGVSVSKEASVELLKLALTSEDERYDEIYLSNYATINIQSALKRIPGVGRVRNTGA 180
+VQ +G+SV K +S L+ S++ + +S+Y N++ L R+ GVG V+ GA
Sbjct: 121 EVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGA 180

Query: 181 RSYSMRVWLNPDTMAGYGLTTSDVIDAIKAQNKESPAGSIGSQPNADTLSMTLPITAAGR 240
+ Y+MR+WL+ D + Y LT DVI+ +K QN + AG +G P + I A R
Sbjct: 181 Q-YAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTR 239

Query: 241 MSSVPQFNEIIVRASADGSIIRLRDIANIELGSSSYTLQSQLNGNNATILQVYLLPGANA 300
+ +F ++ +R ++DGS++RL+D+A +ELG +Y + +++NG A L + L GANA
Sbjct: 240 FKNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGLGIKLATGANA 299

Query: 301 LEVTKKVKSEMAKLAQKFPQGMNWEVFFDASVFIENSIDEVVKTLVEALILVILVVFMFL 360
L+ K +K+++A+L FPQGM +D + F++ SI EVVKTL EA++LV LV+++FL
Sbjct: 300 LDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFL 359

Query: 361 QNIRATLIPAIAVPVSLIGTLAAMLAFGFTINTVSLLALVLAIGIVVDDAIVVVENVERL 420
QN+RATLIP IAVPV L+GT A + AFG++INT+++ +VLAIG++VDDAIVVVENVER+
Sbjct: 360 QNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERV 419

Query: 421 MDEKGLSSSQATKVAMKELSGALIATSLVLAAVFVPVSFLSGITGIMYREFAVAITVAVL 480
M E L +AT+ +M ++ GAL+ ++VL+AVF+P++F G TG +YR+F++ I A+
Sbjct: 420 MMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVSAMA 479

Query: 481 ISTLVALTLSPALCALLLRPG----DKATSGFFKWMNDRLDTATTKYVGLVVLTNKHAKR 536
+S LVAL L+PALCA LL+P + GFF W N D + Y V R
Sbjct: 480 LSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGSTGR 539

Query: 537 SYLLFALMVGGVYLTMSSLPSSFMPDEDQGRFFIDVSLPNGATVNRTQDVLKKAEATVLA 596
L++AL+V G+ + LPSSF+P+EDQG F + LP GAT RTQ VL + L
Sbjct: 540 YLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDYYLK 599

Query: 597 HPAV-AYSFTLAGENRRSGSNQANGQFEIILKPWSDRVDNDATVQKVMNEIKQSLHDVLE 655
+ S SG Q G + LKPW +R ++ + + V++ K L + +
Sbjct: 600 NEKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKMELGKIRD 659

Query: 656 AEFKIYLPSAVPGLGNGSGVEMELQDTSGSNFKGLMETADELVEALKLQP-EIATAGLSL 714
+ A+ LG +G + EL D +G L + ++L+ P + + +
Sbjct: 660 GFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHPASLVSVRPNG 719

Query: 715 QTAIPQLHLNVDEAKAMAIGVKVSDIYGTIKTFTDSSTVNDFNLFGRVYRVKVQAEEQYR 774
Q L VD+ KA A+GV +SDI TI T + VNDF GRV ++ VQA+ ++R
Sbjct: 720 LEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQADAKFR 779

Query: 775 QFPDQIEDYHVRSSSGAMVPIGVLATSDYSVGPAALTHYNMFTSASINASPAPGYASGDV 834
P+ ++ +VRS++G MVP TS + G L YN S I APG +SGD
Sbjct: 780 MLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEIQGEAAPGTSSGDA 839

Query: 835 IRAIERVAKPMLPDEFSYEWTGITYQEVQSANQTAIAVTLAMVFVFLFLAALYESWTLPI 894
+ +E +A LP Y+WTG++YQE S NQ V ++ V VFL LAALYESW++P+
Sbjct: 840 MALMENLASK-LPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLCLAALYESWSIPV 898

Query: 895 AVLLIAPIAMLGASVGTLVSGMESNLFFQVAFIALIGMAAKNSILIVEFANQLH-KEGKS 953
+V+L+ P+ ++G + + +++++F V + IG++AKN+ILIVEFA L KEGK
Sbjct: 899 SVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVEFAKDLMEKEGKG 958

Query: 954 RLDSAIEAANMRFRPILMTSLAFILGVLPLVFSVGPGAVSRQSISIPILCGMIFATTIGI 1013
+++ + A MR RPILMTSLAFILGVLPL S G G+ ++ ++ I ++ GM+ AT + I
Sbjct: 959 VVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGVMGGMVSATLLAI 1018

Query: 1014 IMVPLFFV 1021
VP+FFV
Sbjct: 1019 FFVPVFFV 1026



Score = 104 bits (262), Expect = 7e-25
Identities = 78/511 (15%), Positives = 180/511 (35%), Gaps = 29/511 (5%)

Query: 5 FVNRPVFASVISIVIVLLGLIAMFQLPIDQYPYITPPQVKISASYPGATSTTAAESVATP 64
+ +I +IV ++ +LP P P + + V
Sbjct: 533 ILGSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQ 592

Query: 65 LEQEL-----NGLPNMIYMSSKSTNSGSTNITITF------DVGTNPDLAAVDAQNSTQQ 113
+ + ++ ++ S + + N + F + + +A + +
Sbjct: 593 VTDYYLKNEKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAKM 652

Query: 114 ATGSLPIDVQTEGVSVSKEASVELL---KLALTSEDERYDEI-YLSNYATINIQSALKRI 169
G + + + A VEL D+ L+ + A +
Sbjct: 653 ELGKIRDGF---VIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAAQHP 709

Query: 170 PGVGRVRNTG-ARSYSMRVWLNPDTMAGYGLTTSDVIDAIKAQNKESPAGSIGSQPNADT 228
+ VR G + ++ ++ + G++ SD+ I + +
Sbjct: 710 ASLVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKK 769

Query: 229 LSMTLPITAAGRMSSVPQFNEIIVRASADGSIIRLRDIANIELGSSSYTLQSQLNGNNAT 288
L + +++ VR SA+G ++ S L + NG +
Sbjct: 770 LYVQADAKFR---MLPEDVDKLYVR-SANGEMVPFSAFTTSHWVYGSPRL-ERYNGLPSM 824

Query: 289 ILQVYLLPGANALEVTKKVKSEMAKLAQKFPQGMNWEVFFDASVFIENSIDEVVKTLVEA 348
+Q PG + + M LA K P G+ ++ + S ++ + +
Sbjct: 825 EIQGEAAPGT----SSGDAMALMENLASKLPAGIGYDWTGMSYQERL-SGNQAPALVAIS 879

Query: 349 LILVILVVFMFLQNIRATLIPAIAVPVSLIGTLAAMLAFGFTINTVSLLALVLAIGIVVD 408
++V L + ++ + + VP+ ++G L A F + ++ L+ IG+
Sbjct: 880 FVVVFLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAK 939

Query: 409 DAIVVVENVERLMDEKGLSSSQATKVAMKELSGALIATSLVLAAVFVPVSFLSGITGIMY 468
+AI++VE + LM+++G +AT +A++ ++ TSL +P++ +G
Sbjct: 940 NAILIVEFAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQ 999

Query: 469 REFAVAITVAVLISTLVALTLSPALCALLLR 499
+ + ++ +TL+A+ P ++ R
Sbjct: 1000 NAVGIGVMGGMVSATLLAIFFVPVFFVVIRR 1030



Score = 68.7 bits (168), Expect = 1e-13
Identities = 82/506 (16%), Positives = 179/506 (35%), Gaps = 44/506 (8%)

Query: 538 YLLFALMVGGVYLTMSSLPSSFMPDEDQGRFFIDVSLPNGATVNRTQD-VLKKAEATVLA 596
++L +++ L + LP + P + + P GA QD V + E +
Sbjct: 13 WVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYP-GADAQTVQDTVTQVIEQNMNG 71

Query: 597 HPAVAYSFTLAGENRRSGSNQANGQFEIILKPWSDRVDNDATVQKVMNEIKQSLHDVLEA 656
+ Y ++ + +GS F+ D D +V N+++ +
Sbjct: 72 IDNLMY---MSSTSDSAGSVTITLTFQ-------SGTDPDIAQVQVQNKLQLATPL---- 117

Query: 657 EFKIYLPSAVPGLG-----NGSGVEMELQDTSGSNFKGLMETADELVEALKLQPEIAT-- 709
LP V G + S M S + + +D + +K ++
Sbjct: 118 -----LPQEVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVK--DTLSRLN 170

Query: 710 --AGLSLQTAIPQLHLNVDEAKAMAIGVKVSDIYGTIKTFTDS----STVNDFNLFGRVY 763
+ L A + + +D + D+ +K D L G+
Sbjct: 171 GVGDVQLFGAQYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQL 230

Query: 764 RVKVQAEEQYRQFPDQIEDYHVRSS-SGAMVPIGVLAT-SDYSVGPAALTHYNMFTSASI 821
+ A+ ++ + P++ +R + G++V + +A + N +A +
Sbjct: 231 NASIIAQTRF-KNPEEFGKVTLRVNSDGSVVRLKDVARVELGGENYNVIARINGKPAAGL 289

Query: 822 NASPAPGYASGDVIRAI-ERVA--KPMLPDEFSYEWTGITYQEVQSANQTAI-AVTLAMV 877
A G + D +AI ++A +P P + T VQ + + + A++
Sbjct: 290 GIKLATGANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIM 349

Query: 878 FVFLFLAALYESWTLPIAVLLIAPIAMLGASVGTLVSGMESNLFFQVAFIALIGMAAKNS 937
VFL + ++ + + P+ +LG G N + IG+ ++
Sbjct: 350 LVFLVMYLFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDA 409

Query: 938 ILIVEFANQLHKEGKSR-LDSAIEAANMRFRPILMTSLAFILGVLPLVFSVGPGAVSRQS 996
I++VE ++ E K ++ ++ + ++ ++ +P+ F G +
Sbjct: 410 IVVVENVERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQ 469

Query: 997 ISIPILCGMIFATTIGIIMVPLFFVT 1022
SI I+ M + + +I+ P T
Sbjct: 470 FSITIVSAMALSVLVALILTPALCAT 495


80Spea_2271Spea_2279N        Y        YPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_2271114-2.520792hypothetical protein
Spea_2272015-2.714105pentapeptide repeat-containing protein
Spea_2273116-4.741189hypothetical protein
Spea_2274014-3.933247N-acetyltransferase GCN5
Spea_2275113-3.389622hypothetical protein
Spea_2276012-2.206962radical SAM domain-containing protein
Spea_2277016-4.010989peptidase S15
Spea_2278116-1.645167hypothetical protein
Spea_2279015-2.145256******major facilitator transporter
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2271TCRTETB371e-04 Tetracycline resistance protein TetB signature.
		>TCRTETB#Tetracycline resistance protein TetB signature.

Length = 458

Score = 37.2 bits (86), Expect = 1e-04
Identities = 40/218 (18%), Positives = 90/218 (41%), Gaps = 13/218 (5%)

Query: 4 RNRILLTWISFLSYALTGSLIIVTGIVMGDIAKFFNLPISSMSNTFTFLNTGVLISIFLN 63
R+ +L W+ LS+ + +V + + DIA FN P +S + T I +
Sbjct: 11 RHNQILIWLCILSF-FSVLNEMVLNVSLPDIANDFNKPPASTNWVNTAFMLTFSIGTAVY 69

Query: 64 VWLMEIIALKKQLIFGFILMVLAVLGLMFGHNLA-IFSASMFVLGVVSGITMSIGTYLIT 122
L + + +K+ L+FG I+ + GH+ + + F+ G + ++ ++
Sbjct: 70 GKLSDQLGIKRLLLFGIIINCFGSVIGFVGHSFFSLLIMARFIQGAGAAAFPALVMVVVA 129

Query: 123 RLYHGKQCGSRLLFTDSFFSMAGMIFPLISAALLAHSVAWYWVYAAIGMIYVAIFILALV 182
R + G S +M + P I + + I Y+ + + +
Sbjct: 130 RYIPKENRGKAFGLIGSIVAMGEGVGPAIGGMIAHY----------IHWSYLLLIPMITI 179

Query: 183 CEFPVLIKSEEQQQAVKEKWGL-GILFLAIAALCYILG 219
P L+K +++ +K + + GI+ +++ + ++L
Sbjct: 180 ITVPFLMKLLKKEVRIKGHFDIKGIILMSVGIVFFMLF 217


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2272cloacin402e-05 Cloacin signature.
		>cloacin#Cloacin signature.

Length = 551

Score = 40.5 bits (94), Expect = 2e-05
Identities = 27/82 (32%), Positives = 30/82 (36%), Gaps = 2/82 (2%)

Query: 560 GNGGNGANDGKDGIGGQ--GGQGFLGANSEWVNGDPGVGSNGRGGNADDSFSASGGGGGG 617
G G G N G G GG LG +G N G S GGG G
Sbjct: 3 GGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGH 62

Query: 618 GGYGGGGAGDDGAGAGGGSWSV 639
G GG G G+G GG +V
Sbjct: 63 GNGGGNGNSGGGSGTGGNLSAV 84



Score = 35.8 bits (82), Expect = 6e-04
Identities = 24/81 (29%), Positives = 30/81 (37%), Gaps = 5/81 (6%)

Query: 552 DGGSTDEWGNGGNGANDGKDGIGGQGGQGFLGANSEWVNGDPGVGSNGRGGNADDSFSAS 611
+ G+ GN G G G G G+ N+ W G GS S +
Sbjct: 10 NTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPW-----GGGSGSGIHWGGGSGHGN 64

Query: 612 GGGGGGGGYGGGGAGDDGAGA 632
GGG G G G G G+ A A
Sbjct: 65 GGGNGNSGGGSGTGGNLSAVA 85


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2274SACTRNSFRASE523e-11 Streptothricin acetyltransferase signature.
		>SACTRNSFRASE#Streptothricin acetyltransferase signature.

Length = 173

Score = 51.9 bits (124), Expect = 3e-11
Identities = 27/96 (28%), Positives = 45/96 (46%), Gaps = 3/96 (3%)

Query: 31 DDVVFEPDTKFAAFAKDENGKVVGGIRAVAFWN-YCILELLWLSDETRGQGVGSKLMDAA 89
DV + + AAF +G I+ + WN Y ++E + ++ + R +GVG+ L+ A
Sbjct: 55 MDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAVAKDYRKKGVGTALLHKA 114

Query: 90 ENFAKEKGFGYMRTETLSFQ--AKPFYEKRGYKVFG 123
+AKE F + ET A FY K + +
Sbjct: 115 IEWAKENHFCGLMLETQDINISACHFYAKHHFIIGA 150


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2276SECA330.005 SecA protein signature.
		>SECA#SecA protein signature.

Length = 901

Score = 32.5 bits (74), Expect = 0.005
Identities = 15/58 (25%), Positives = 21/58 (36%), Gaps = 15/58 (25%)

Query: 30 RGYEAVQRDPAIE-------LFIEMMTAPALEVIRQ------HVEENYEHFEDDELPD 74
RGY Q+DP E +F M+ + EVI + E E E +
Sbjct: 792 RGYA--QKDPKQEYKRESFSMFAAMLESLKYEVISTLSKVQVRMPEEVEELEQQRRME 847


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2279TCRTETA612e-12 Tetracycline resistance protein signature.
		>TCRTETA#Tetracycline resistance protein signature.

Length = 399

Score = 61.4 bits (149), Expect = 2e-12
Identities = 59/343 (17%), Positives = 113/343 (32%), Gaps = 15/343 (4%)

Query: 49 IALQNLLFGVFQPFVGMAADRFGSKRVIMLGAIAYGLGLLLTSISTSTEMFYVSISMLIG 108
+AL L+ P +G +DRFG + V+++ + + + + + Y I ++
Sbjct: 49 LALYALMQFACAPVLGALSDRFGRRPVLLVSLAGAAVDYAIMATAPFLWVLY--IGRIVA 106

Query: 109 LGLSATSYVVVLGAVAKVVPAEHTAKAFGLTTAAGSFGMFAVIPGAQSLLTEFDWQTALQ 168
G++ + V +A + + A+ FG +A FGM A P L+ F
Sbjct: 107 -GITGATGAVAGAYIADITDGDERARHFGFMSACFGFGMVAG-PVLGGLMGGFSPHAPFF 164

Query: 169 VFALLCCFMFAFASF-MKTVKPSETSSEQLDDQTLTEALKQACTNRNYWLIHLGFFVCGF 227
A L F F + E + + + + A + FF+
Sbjct: 165 AAAALNGLNFLTGCFLLPESHKGERRPLRREALNPLASFRWARGMTVVAALMAVFFIMQL 224

Query: 228 HVMFIATHLPSYLSDK-HLDSSTAALALAYVGIFNIFGSYFWGVMGDKFNKRYVMSALYL 286
A + D+ H D++T ++LA GI + ++ R
Sbjct: 225 VGQVPAALWVIFGEDRFHWDATTIGISLAAFGILHSL---AQAMITGPVAARL--GERRA 279

Query: 287 IRTVVIA---AFVTLPVTNHTAAIFGAAIGFCWLG-TVPLTSGLVRQIFGARYLSTLYGL 342
+ +IA ++ L F + G +P ++ + L G
Sbjct: 280 LMLGMIADGTGYILLAFATRGWMAFPIMVLLASGGIGMPALQAMLSRQVDEERQGQLQGS 339

Query: 343 VFFTHQIGSFLGAWVGGRIYDYYGSYEPIWWSTVVLAFVAALL 385
+ + S +G + IY + W A L
Sbjct: 340 LAALTSLTSIVGPLLFTAIYAASITTWNGWAWIAGAALYLLCL 382



Score = 35.6 bits (82), Expect = 3e-04
Identities = 25/102 (24%), Positives = 44/102 (43%), Gaps = 4/102 (3%)

Query: 46 SFAIALQNLLFGVFQPFV-GMAADRFGSKRVIMLGAIAYGLGLLLTSISTSTEMFYVSIS 104
++A +L + Q + G A R G +R +MLG IA G G +L + +T M + +
Sbjct: 249 GISLAAFGILHSLAQAMITGPVAARLGERRALMLGMIADGTGYILLAFATRGWMAFPIMV 308

Query: 105 MLIGLGLSATSYVVVLGAVAKVVPAEHTAKAFGLTTAAGSFG 146
+L G+ + +++ V E + G A S
Sbjct: 309 LLASGGIGMPALQ---AMLSRQVDEERQGQLQGSLAALTSLT 347


81Spea_2517Spea_2523N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_25170141.652108OmpA/MotB domain-containing protein
Spea_25180131.824170two component transcriptional regulator
Spea_2519-1131.526630histidine kinase
Spea_2520-1130.898270cystathionine beta-lyase
Spea_2521-1130.702507hypothetical protein
Spea_2522-2140.633065CreA family protein
Spea_2523-2140.783958putative chaperone
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2517OMPADOMAIN726e-17 OMPA domain signature.
		>OMPADOMAIN#OMPA domain signature.

Length = 346

Score = 72.3 bits (177), Expect = 6e-17
Identities = 26/95 (27%), Positives = 48/95 (50%), Gaps = 2/95 (2%)

Query: 126 ELALGLNVQFKTGSSVIEPHFQQQLNDIAYAMS--LSPELTLDLTGYADRRGDSDYNQAL 183
L +V F + ++P Q L+ + +S + ++ + GY DR G YNQ L
Sbjct: 214 HFTLKSDVLFNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGL 273

Query: 184 SEQRVAEVKNYLTEQGVEEERLHNQAFGDSSPLMA 218
SE+R V +YL +G+ +++ + G+S+P+
Sbjct: 274 SERRAQSVVDYLISKGIPADKISARGMGESNPVTG 308


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2518HTHFIS675e-15 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 66.8 bits (163), Expect = 5e-15
Identities = 30/134 (22%), Positives = 55/134 (41%), Gaps = 4/134 (2%)

Query: 3 RIAIVEDEAAIRENYKEVLQQQGYCVQAYANRPEAMLAFNTRLPDLAIIDIGLENEIDGG 62
I + +D+AAIR + L + GY V+ +N DL + D+ + +E
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDE--NA 62

Query: 63 FTLCQSLRAMSSTLPIIFLTARDSDFDTVCGLRLGADDYLSKDVSFPHLIA--RLAALFR 120
F L ++ LP++ ++A+++ + GA DYL K LI A
Sbjct: 63 FDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEP 122

Query: 121 RSDLKNVDSDNNQI 134
+ ++ D+
Sbjct: 123 KRRPSKLEDDSQDG 136


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2521BCTERIALGSPG445e-08 Bacterial general secretion pathway protein G signa...
		>BCTERIALGSPG#Bacterial general secretion pathway protein G

signature.
Length = 145

Score = 43.7 bits (103), Expect = 5e-08
Identities = 16/56 (28%), Positives = 31/56 (55%)

Query: 4 MQRPTASKGFTLIELVIVIIVLGILAVIAAAKYVDLKRDAEIARVKGVAAAFEQSL 59
M+ +GFTL+E+++VI+++G+LA + + K A+ + A E +L
Sbjct: 1 MRATDKQRGFTLLEIMVVIVIIGVLASLVVPNLMGNKEKADKQKAVSDIVALENAL 56


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2523SHAPEPROTEIN476e-08 Bacterial cell shape determinant MreB/Mbl protein s...
		>SHAPEPROTEIN#Bacterial cell shape determinant MreB/Mbl protein

signature.
Length = 347

Score = 47.4 bits (113), Expect = 6e-08
Identities = 40/158 (25%), Positives = 70/158 (44%), Gaps = 25/158 (15%)

Query: 109 VRSPKSFLGATGLRESQIALFEDIVTLMMMHIKQQAESN--FSPAQKITHAVIGRPVNFQ 166
R+P + +++ IA F + M+ H +Q SN P+ ++ ++ PV
Sbjct: 64 GRTPGNIAAIRPMKDGVIADFF-VTEKMLQHFIKQVHSNSFMRPSPRV---LVCVPVGAT 119

Query: 167 GIGGEQSNQQAEAILSLAASRAGFTEVDFLFEPLAAGMDYEASLDENVTVLVVDVGGGTT 226
+ + AI +A AG EV + EP+AA + + E +VVD+GGGTT
Sbjct: 120 QV-------ERRAIRE-SAQGAGAREVFLIEEPMAAAIGAGLPVSEATGSMVVDIGGGTT 171

Query: 227 DCSMVKMGPNHIDNRDRSADFLGHSGQRIGGNDLDIAL 264
+ +++ + + S RIGG+ D A+
Sbjct: 172 EVAVISLN-----------GVVYSSSVRIGGDRFDEAI 198



Score = 34.3 bits (79), Expect = 8e-04
Identities = 23/116 (19%), Positives = 47/116 (40%), Gaps = 18/116 (15%)

Query: 340 YKLV---RSAEQSKIALSSDACVDTPLEY-IH-----AGL--HARVSEDDFESAITIPLS 388
Y + +AE+ K + S D E + G+ ++ ++ A+ PL+
Sbjct: 206 YGSLIGEATAERIKHEIGSAYPGDEVREIEVRGRNLAEGVPRGFTLNSNEILEALQEPLT 265

Query: 389 KVEALMREALEQ------AGVMPDRIYVTGGTARSPAIYKRISGLFPEIPIVVGDH 438
+ + + ALEQ + + + +TGG A + + + IP+VV +
Sbjct: 266 GIVSAVMVALEQCPPELASDISERGMVLTGGGALLRNLDRLLME-ETGIPVVVAED 320


82Spea_2669Spea_2680N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_26690130.126880phage shock protein A
Spea_2670012-0.113707Fis family transcriptional regulator
Spea_2671-210-0.213183extracellular solute-binding protein
Spea_2672-114-0.446640binding-protein-dependent transport system inner
Spea_2673018-0.221042binding-protein-dependent transport system inner
Spea_2674118-0.426748oligopeptide/dipeptide ABC transporter ATPase
Spea_2675221-0.855417ABC transporter-like protein
Spea_2676322-0.538447trans-2-enoyl-CoA reductase
Spea_2677527-0.721513PpiC-type peptidyl-prolyl cis-trans isomerase
Spea_2678424-0.393756histone family protein DNA-binding protein
Spea_2679321-0.325969ATP-dependent protease La
Spea_2680326-0.636144ATP-dependent protease ATP-binding subunit ClpX
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2669RTXTOXIND290.013 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 29.0 bits (65), Expect = 0.013
Identities = 26/156 (16%), Positives = 62/156 (39%), Gaps = 18/156 (11%)

Query: 42 EVRSTSAKVLAEKKEIIRR-IAKVQEQVQDWESKAELALSKDREDLAKAALVEKQKANDL 100
+ A++ + +I+ R I + + + E L +L+++Q +
Sbjct: 140 QSSLLQARLEQTRYQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQ 199

Query: 101 AQ---------TLAAELVVVEEHILRLKDEVNLLQEKLADAKARQKTIIMRKQTASSRLE 151
Q AE + V I R ++ + + +L D + + + A ++
Sbjct: 200 NQKYQKELNLDKKRAERLTVLARINRYENLSRVEKSRLDDFSS------LLHKQAIAKHA 253

Query: 152 VKKQLDSSKIDNAMSKFEQYERRVESLESQVDSYDL 187
V +Q +K A+++ Y+ ++E +ES++ S
Sbjct: 254 VLEQ--ENKYVEAVNELRVYKSQLEQIESEILSAKE 287


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2670HTHFIS349e-119 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 349 bits (896), Expect = e-119
Identities = 118/363 (32%), Positives = 184/363 (50%), Gaps = 21/363 (5%)

Query: 6 QQDNLIGQSNALLEVLEHISQVAPLSKPVLIIGERGTGKELIAERLHYLSKRWDQSFIKL 65
L+G+S A+ E+ ++++ ++I GE GTGKEL+A LH KR + F+ +
Sbjct: 135 DGMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVARALHDYGKRRNGPFVAI 194

Query: 66 NCSSLSENLLESELFGHDAGAFTGASKKHEGRFERADGGTLFLDELANTSGLIQEKLLRV 125
N +++ +L+ESELFGH+ GAFTGA + GRFE+A+GGTLFLDE+ + Q +LLRV
Sbjct: 195 NMAAIPRDLIESELFGHEKGAFTGAQTRSTGRFEQAEGGTLFLDEIGDMPMDAQTRLLRV 254

Query: 126 IEYGEFERVGGSKTVQTNVRLVCAANEDLPSLAEAGEFRPDLLDRLAFDVITLPPLRHRS 185
++ GE+ VGG ++++VR+V A N+DL G FR DL RL + LPPLR R+
Sbjct: 255 LQQGEYTTVGGRTPIRSDVRIVAATNKDLKQSINQGLFREDLYYRLNVVPLRLPPLRDRA 314

Query: 186 EDIMPLAEYFAIGMARQLKLELFEGFSCNAIEQLMEYQWPGNIRELKNVVERSVYRNAET 245
EDI L +F ++ F A+E + + WPGN+REL+N+V R
Sbjct: 315 EDIPDLVRHFVQQAEKEGLDVK--RFDQEALELMKAHPWPGNVRELENLVRRLTAL-YPQ 371

Query: 246 NTAIDQIIIDPFAS--PYRPTKRVKTKERQQTVSPEVNSAATNSSAEVSANPSADMSTNN 303
+ +II + S P P ++ + ++S V A
Sbjct: 372 DVITREIIENELRSEIPDSPIEKAAARSGSLSISQAVEENMRQYFASFGDALPP------ 425

Query: 304 SAAADAKVNFPIDFKTHCEQGEVRILKQALEAGQFNQKKTAELLGLSYHQLRGILKKYNL 363
+ + E ++ AL A + NQ K A+LLGL+ + LR +++ +
Sbjct: 426 ----------SGLYDRVLAEMEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIRELGV 475

Query: 364 LDK 366

Sbjct: 476 SVY 478


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2674HTHFIS310.010 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 30.6 bits (69), Expect = 0.010
Identities = 9/16 (56%), Positives = 14/16 (87%)

Query: 38 LVGESGSGRTLLARAI 53
+ GESG+G+ L+ARA+
Sbjct: 165 ITGESGTGKELVARAL 180


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2675PF05272300.015 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 29.7 bits (66), Expect = 0.015
Identities = 12/50 (24%), Positives = 19/50 (38%), Gaps = 1/50 (2%)

Query: 43 LAIVGEAGSGKSTIARILVGAEIRSGGEIFFEGEPLDKHDLKQRCRLIRM 92
+ + G G GKST+ LVG + S G D ++ +
Sbjct: 599 VVLEGTGGIGKSTLINTLVGLDFFSDTHFDI-GTGKDSYEQIAGIVAYEL 647


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2678DNABINDINGHU1172e-38 Prokaryotic integration host factor signature.
		>DNABINDINGHU#Prokaryotic integration host factor signature.

Length = 91

Score = 117 bits (295), Expect = 2e-38
Identities = 50/88 (56%), Positives = 67/88 (76%)

Query: 2 NKSELIEKIASGADISKAAAGRALDSFIGAVTEGLKEGDKIALVGFGTFEVRQRAERTGR 61
NK +LI K+A +++K + A+D+ AV+ L +G+K+ L+GFG FEVR+RA R GR
Sbjct: 3 NKQDLIAKVAEATELTKKDSAAAVDAVFSAVSSYLAKGEKVQLIGFGNFEVRERAARKGR 62

Query: 62 NPQTGKEIKIAAANIPAFKAGKALKDAV 89
NPQTG+EIKI A+ +PAFKAGKALKDAV
Sbjct: 63 NPQTGEEIKIKASKVPAFKAGKALKDAV 90


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2679HTHFIS350.001 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 34.8 bits (80), Expect = 0.001
Identities = 28/152 (18%), Positives = 60/152 (39%), Gaps = 26/152 (17%)

Query: 304 HKRSKIKRDLAKAQDVLD--TDHFGLEKVKERILEYLAVQSRVKQLKGPILCLVGPPGVG 361
+ + + +QD + ++++ + +R+ Q ++ + G G G
Sbjct: 121 EPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVL-------ARLMQTDLTLM-ITGESGTG 172

Query: 362 KTSLGQSIAKATGRK---YVRVALGGVRD---EAEIRGHRRTYIGSMPGKVIQKMSKVGV 415
K + +++ R+ +V + + + E+E+ GH + G+ G + +
Sbjct: 173 KELVARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEK---GAFTGAQTRSTGRFEQ 229

Query: 416 KN--PLFLLDEIDKMSSDMRGDPASALLEVLD 445
LFL DEI M D + + LL VL
Sbjct: 230 AEGGTLFL-DEIGDMPMDAQ----TRLLRVLQ 256


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2680HTHFIS310.013 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 30.6 bits (69), Expect = 0.013
Identities = 14/74 (18%), Positives = 30/74 (40%), Gaps = 13/74 (17%)

Query: 60 QDQDKLPTPHELRAHLDDYVIGQDKAKKVLAVAVYNHYKRLRNASPKDGVELGKSNILLI 119
+ + P+ E + ++G+ A + + Y+ L D +++
Sbjct: 120 AEPKRRPSKLEDDSQDGMPLVGRSAAMQEI-------YRVLARLMQTD------LTLMIT 166

Query: 120 GPTGSGKTLLAETL 133
G +G+GK L+A L
Sbjct: 167 GESGTGKELVARAL 180


83Spea_2703Spea_2708N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_2703-114-0.155377transcriptional regulator CdaR
Spea_2704-115-0.557862type IV pilin
Spea_2705-116-0.324070OmpA/MotB domain-containing protein
Spea_2706-114-0.994755hypothetical protein
Spea_2707-113-1.500524hypothetical protein
Spea_2708-211-0.903664hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2703HTHFIS310.006 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 31.3 bits (71), Expect = 0.006
Identities = 10/32 (31%), Positives = 20/32 (62%)

Query: 325 LTAYLQHFGDLQQCANVLFIHRNTLRYRLDKI 356
L A G+ + A++L ++RNTLR ++ ++
Sbjct: 442 LAALTATRGNQIKAADLLGLNRNTLRKKIREL 473


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2704BCTERIALGSPG443e-08 Bacterial general secretion pathway protein G signa...
		>BCTERIALGSPG#Bacterial general secretion pathway protein G

signature.
Length = 145

Score = 44.1 bits (104), Expect = 3e-08
Identities = 18/58 (31%), Positives = 38/58 (65%), Gaps = 4/58 (6%)

Query: 4 ASTRRTGFTLIEMVVVIIVLGIIAVIALPKFVNF--HSDSKVATLDGIAAAMKSGLDL 59
A+ ++ GFTL+E++VVI+++G++A + +P + +D + A D A+++ LD+
Sbjct: 3 ATDKQRGFTLLEIMVVIVIIGVLASLVVPNLMGNKEKADKQKAVSD--IVALENALDM 58


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2705OMPADOMAIN1411e-41 OMPA domain signature.
		>OMPADOMAIN#OMPA domain signature.

Length = 346

Score = 141 bits (358), Expect = 1e-41
Identities = 87/350 (24%), Positives = 142/350 (40%), Gaps = 50/350 (14%)

Query: 4 MTKTLFCLLSPMFVYSSAAVAEGYYSDGDFYFGAKLGGALLDSQAKQEPEENKAVN-LSS 62
M KT + + + A VA+ D +Y GAKLG + N L +
Sbjct: 1 MKKTAIAIAVALAGF--ATVAQAAPKDNTWYTGAKLGWSQYHDTGFINNNGPTHENQLGA 58

Query: 63 GLVFGYNLNRYLALESDLSYLGKGQDKQQSTLSADKHLFSIATYLS--TRYRLSDEASLY 120
G GY +N Y+ E +LG+ K A K + L+ Y ++D+ +Y
Sbjct: 59 GAFGGYQVNPYVGFEMGYDWLGRMPYKGSVENGAYK---AQGVQLTAKLGYPITDDLDIY 115

Query: 121 FKLGPAWVNDD-------------ISISSGLGIKYRFSPRWELDTGYRWI-----KDTPS 162
+LG D +S G++Y +P Y+W T
Sbjct: 116 TRLGGMVWRADTKSNVYGKNHDTGVSPVFAGGVEYAITPEIATRLEYQWTNNIGDAHTIG 175

Query: 163 TDDDLYEFTLGFNYKFGVVSHPSVRPAIDPMHKPLDKQQVLITPTINVQSVSIRGNSVFG 222
T D +LG +Y+FG + P+ P + + +++ + +F
Sbjct: 176 TRPDNGMLSLGVSYRFG---------QGEAA--PVVAPAPAPAPEVQTKHFTLKSDVLFN 224

Query: 223 FDSSKLTDTS--ALDEVIK--SALASKNASISVTAYTDSLGAERYNLALAKRRAEATQAY 278
F+ + L ALD++ S L K+ S+ V YTD +G++ YN L++RRA++ Y
Sbjct: 225 FNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGLSERRAQSVVDY 284

Query: 279 FITHGVAPSRIHIDWKGEENPVSSNMTAKGR---------ALNRRVEIEI 319
I+ G+ +I GE NPV+ N + A +RRVEIE+
Sbjct: 285 LISKGIPADKISARGMGESNPVTGNTCDNVKQRAALIDCLAPDRRVEIEV 334


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2706RTXTOXIND310.011 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 30.6 bits (69), Expect = 0.011
Identities = 8/22 (36%), Positives = 13/22 (59%), Gaps = 2/22 (9%)

Query: 314 LVADGQVVEKGQ--AQIDAPGA 333
+V +G+ V KG ++ A GA
Sbjct: 111 IVKEGESVRKGDVLLKLTALGA 132


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2708PF00577604e-11 Outer membrane usher protein FimD
		>PF00577#Outer membrane usher protein FimD

Length = 878

Score = 59.9 bits (145), Expect = 4e-11
Identities = 69/476 (14%), Positives = 138/476 (28%), Gaps = 92/476 (19%)

Query: 285 RIEVYRDSHLIYSKNVDSGQQSIAFRDLPYGSY--TATVVVI-AAGREILKERQQIVN-- 339
++ + ++ + IY+ V G +I D+ V + A G + V
Sbjct: 310 QVTIKQNGYDIYNSTVPPGPFTI--NDIYAAGNSGDLQVTIKEADGST----QIFTVPYS 363

Query: 340 NSAFSLNKGEYDYSFSAGRFNDRYEDSYEGVVEQNRQRQLIKLQAKLGYRVNSDSLQADA 399
+ +G YS +AG + + Q+ L + +
Sbjct: 364 SVPLLQREGHTRYSITAGEYRSGNAQQEKPRF----------FQSTLLHGLP------AG 407

Query: 400 VNLSAQAIALDAYLEALPEQSKLQLDSNNFVEGKFSYQLT--------DSTMVGARLLSN 451
+ D Y + N G S +T DS G +
Sbjct: 408 WTIYGGTQLADRYRAFN-----FGIGKNMGALGALSVDMTQANSTLPDDSQHDGQSVRFL 462

Query: 452 SDSTLSELGIKTSFNDASTAQFKYASFSNGSQFMAADVSFYSIGVGYEKFDSADSDFGLD 511
+ +L+E G T+ ++ + + N + + ++ Y+I + D
Sbjct: 463 YNKSLNESG--TNIQLVGY-RYSTSGYFNFADTTYSRMNGYNI--ETQDGVIQVKPKFTD 517

Query: 512 NFMLSNTGYQRLNVNLSSDLWGGQGYLLYVNNKLDATNSPALFVDQSDYW-------SVS 564
+ L+ +L + ++ L G L L YW
Sbjct: 518 YYNLAYNKRGKLQLTVTQQL-GRTSTL-------------YLSGSHQTYWGTSNVDEQFQ 563

Query: 565 AGFSHSFIADSV-INFSATFQGGDSFGVEDDWYAGVLWSVPLSAGWSASSSVSVSRQGLD 623
AG + +F + +++S T + +V + S +
Sbjct: 564 AGLNTAFEDINWTLSYSLTKNAWQK-----GRDQMLALNVNIPFSHWLRSDSKSQWRHA- 617

Query: 624 EFRNSVANDRQVTRNLSMNNELGISYNGTDVDRNMSSDLSSNISY-DNSYVASDTYAYIS 682
S + N M N G+ D N+S + + + + S YA ++
Sbjct: 618 ----SASYSMSHDLNGRMTNLAGVYG-TLLEDNNLSYSVQTGYAGGGDGNSGSTGYATLN 672

Query: 683 SDGTH-----SVSSSFNSTQ--------VLSAKGEAYFTSEQSDSYIIVDAQNQGG 725
G + S S + Q VL+ +D+ ++V A
Sbjct: 673 YRGGYGNANIGYSHSDDIKQLYYGVSGGVLAHANGVTLGQPLNDTVVLVKAPGAKD 728


84Spea_2961Spea_2970N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_2961-211-1.609966diguanylate cyclase
Spea_2962-113-0.585713hypothetical protein
Spea_2963-211-0.235441putative lipoprotein
Spea_2964-311-0.008506glutathione peroxidase
Spea_2965-312-0.157746peptidase M1 membrane alanine aminopeptidase
Spea_2966-117-0.403813collagenase
Spea_2967015-0.324643phosphate-binding protein
Spea_2968-110-1.174216PAS/PAC sensor signal transduction histidine
Spea_2969112-2.207411two component transcriptional regulator
Spea_2970112-2.212713porin
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2961PF04647310.011 Accessory gene regulator B
		>PF04647#Accessory gene regulator B

Length = 212

Score = 30.5 bits (69), Expect = 0.011
Identities = 27/149 (18%), Positives = 52/149 (34%), Gaps = 12/149 (8%)

Query: 167 SDIYALFIILCIGGLIFITLYNGIIYVS---IRDKAFLYYA-CYVLCYLTGWALTFHLP- 221
++ + IIL + +I + +S R + + Y C LT + L
Sbjct: 34 GTVFQIIIILLVAFVIGLAKEVAFCLLSAAVYRRFSGGAHCEKYYRCTLTSLLVFNVLAY 93

Query: 222 -AHLFDFHNLELHHLFFIGLPIFNILFY------IHFLQLPELSPKLYRLSLGLLWLCII 274
AHL D +L L + +LF + + E L + +L +
Sbjct: 94 IAHLIDPAYFQLLILIAFITSLLALLFLVPVDNPRNLISNTEQRKTLKLKTSMVLMVLFG 153

Query: 275 ALPTSMYLVSYTAIIASVLIMLWIGLAMF 303
+ L ++ +A +L +LW +
Sbjct: 154 GSIGAYRLYTHQIALAILLGVLWQTFTLT 182


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2964PF03627280.019 PapG
		>PF03627#PapG

Length = 336

Score = 28.0 bits (62), Expect = 0.019
Identities = 13/42 (30%), Positives = 20/42 (47%), Gaps = 7/42 (16%)

Query: 77 QAISSFCELNFGVTFPLFEKIEVNGANTAPLYAHLKQSAKGL 118
Q +S C++ + F L NT P Y+H K+ + GL
Sbjct: 243 QTLSVSCDVPANIRFMLL-------RNTTPTYSHGKKFSVGL 277


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2966MICOLLPTASE1714e-50 Microbial collagenase metalloprotease (M9) signature.
		>MICOLLPTASE#Microbial collagenase metalloprotease (M9) signature.

Length = 1104

Score = 171 bits (434), Expect = 4e-50
Identities = 47/279 (16%), Positives = 104/279 (37%), Gaps = 43/279 (15%)

Query: 39 ESVLSQNHACSDTI-VIRSQA-LTEKQLSSACQLLIKQEASFHKLFGTLNKPVADDNNHK 96
E L + + D V+++ +TE+++ + +A F ++ + +
Sbjct: 387 EKYLPKTYTFDDGKFVVKAGDKVTEEKIKRLYWASKEVKAQFMRVVQNDKALEEGNPDDI 446

Query: 97 MRANVYHSRQDYVDHVTNHFDVPSDNGGMYLEGLPWESDNQAEFVAYEKKGQ-----VWN 151
+ +Y+S ++Y +DNGG+Y+E N F YE+ + +
Sbjct: 447 LTVVIYNSPEEY-KLNRIINGFSTDNGGIYIE-------NIGTFFTYERTPEESIYTLEE 498

Query: 152 LA-HEYVHYLDGRFNLYGDFCLSLHDSHSGPEYCPKPAPLYPHTVWWSEGVAEYISLGDN 210
L HE+ HYL GR+ + G + W+ EG AE+ +
Sbjct: 499 LFRHEFTHYLQGRYVVPGMWGQGEFYQEG-------------VLTWYEEGTAEFFAGSTR 545

Query: 211 NPKAIAL------IGGEPSYK--LSEIFNTSYEKNGGTDRVYRWGYLAVRFMIENHKDKV 262
+ + + + L + + Y G+ Y +G+ +M N+
Sbjct: 546 TDGIKPRKSVTQGLAYDRNNRMSLYGVLHAKY----GSWDFYNYGFALSNYMYNNNMGMF 601

Query: 263 DTMLGFTRKGDYPRYQALLAGWGT--SMDAEFDTWLEQL 299
+ M + + D Y+ +A + ++ ++ +++ L
Sbjct: 602 NKMTNYIKNNDVSGYKDYIASMSSDYGLNDKYQDYMDSL 640



Score = 83.2 bits (205), Expect = 9e-20
Identities = 26/169 (15%), Positives = 50/169 (29%), Gaps = 39/169 (23%)

Query: 147 GQVWNLAHEYVHYLDGRFNLYGDFCLSLHDSHSGPEYCPKPAPLYPHTVWWSEGVAEYIS 206
+ L +Y Y+D N + + L + + A+ I+
Sbjct: 624 SSDYGLNDKYQDYMDSLLNNIDNLDVPLVSD-----------------EYVNGHEAKDIN 666

Query: 207 LGDNNPKAIALIGGEPSYKLSEIFNTSYEKNGGTDRVYRWGYLAVRFMIENH-----KDK 261
N+ K ++ I S F T+Y+ R Y+ R E + K
Sbjct: 667 EITNDIKEVSNIKDLSSNVEKSQFFTTYD--------MRGTYVGGRSQGEENDWKDMNSK 718

Query: 262 VDTMLGFTRKGDYPRYQALLAGW---------GTSMDAEFDTWLEQLKS 301
++ +L K + Y+ + A + D F +
Sbjct: 719 LNDILKELSKKSWNGYKTVTAYFVNHKVDGNGNYVYDVVFHGMNTDTNT 767


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2968PF06580340.001 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 34.1 bits (78), Expect = 0.001
Identities = 18/106 (16%), Positives = 37/106 (34%), Gaps = 26/106 (24%)

Query: 327 LISNAIRY----TEPGGKVEISWRKIAIGGLFSVKDNGEGIAPHHIGRLTERFYRVDSAR 382
L+ N I++ GGK+ + K V++ G +
Sbjct: 263 LVENGIKHGIAQLPQGGKILLKGTKDNGTVTLEVENTGSLALKN---------------- 306

Query: 383 SRQSGGTGLGLAITKH---ALHNHQSELNIASQLGKGSTFSFVIPA 425
TG GL + L+ ++++ ++ + GK + +IP
Sbjct: 307 --TKESTGTGLQNVRERLQMLYGTEAQIKLSEKQGKVNAM-VLIPG 349


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2969HTHFIS921e-23 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 91.8 bits (228), Expect = 1e-23
Identities = 34/138 (24%), Positives = 63/138 (45%), Gaps = 5/138 (3%)

Query: 3 ARILIVEDELAIREMLTFVLEQHGYTTVAAEDYDSALDMLTEPYPDLVLLDWMFPGGSGI 62
A IL+ +D+ AIR +L L + GY + + + DLV+ D + P +
Sbjct: 4 ATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAF 63

Query: 63 QLAKRLRQDEFTRHIPIIMLTARGEEEDKVRGLEVGADDFMTKPFSPKELVARIKAVM-- 120
L R+++ +P+++++A+ ++ E GA D++ KPF EL+ I +
Sbjct: 64 DLLPRIKKAR--PDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAE 121

Query: 121 -RRSAPTCLEDPIDVQGL 137
+R +D D L
Sbjct: 122 PKRRPSKLEDDSQDGMPL 139


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_2970ECOLNEIPORIN663e-14 E.coli/Neisseria porin superfamily signature.
		>ECOLNEIPORIN#E.coli/Neisseria porin superfamily signature.

Length = 331

Score = 65.6 bits (160), Expect = 3e-14
Identities = 49/225 (21%), Positives = 92/225 (40%), Gaps = 17/225 (7%)

Query: 13 AVATATMSSAYAADPLTVYGKLN--VTAQSNDVND-------ESTTTIQSNASRFGVKGA 63
A+ A + A AD +T+YG + V + ++ E+ T I S+ G KG
Sbjct: 7 ALTLAALPVAAMAD-VTLYGTIKAGVETSRSVAHNGAQAASVETGTGIVDLGSKIGFKGQ 65

Query: 64 FELSNSLEAFYTVEYEVDTGDSSKDNFEARNQFVGLRGNFGAFSVGRNDTMLKAS---QG 120
+L N L+A + VE + + R F+GL+G FG VGR +++LK +
Sbjct: 66 EDLGNGLKAIWQVEQKASIAGTDSGWGN-RQSFIGLKGGFGKLRVGRLNSVLKDTGDINP 124

Query: 121 KVDQFNDLSGDLKNLFKGENRIEQTATYITPSFGGFKVGVTYAAEGASSQYTQDGFSVAA 180
+ + L + + + E R+ + Y +P F G V YA + ++ + +
Sbjct: 125 WDSKSDYLGVN--KIAEPEARL-ISVRYDSPEFAGLSGSVQYALNDNAGRHNSESYHAGF 181

Query: 181 MYGDAKLKKSPIYASVAYDSDVKGYEVARATVQGKIAGLKLGAMY 225
Y + A + + + + + ++G A+Y
Sbjct: 182 NYKNGGFFVQYGGAYKRHHQVQENVNIEKYQIHRLVSGYDNDALY 226


85Spea_3049Spea_3055N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_3049025-1.378365nucleoside-specific channel-forming protein Tsx
Spea_3050131-1.329966nucleoside transporter
Spea_3051121-1.306659TatD-like deoxyribonuclease
Spea_3052225-1.001888hypothetical protein
Spea_3053224-0.889606peptide chain release factor 3
Spea_3054323-1.047854lipoprotein NlpI
Spea_3055434-0.561480polynucleotide phosphorylase/polyadenylase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3049CHANNELTSX764e-18 Nucleoside-specific channel-forming protein Tsx signa...
		>CHANNELTSX#Nucleoside-specific channel-forming protein Tsx

signature.
Length = 294

Score = 76.2 bits (187), Expect = 4e-18
Identities = 83/305 (27%), Positives = 124/305 (40%), Gaps = 32/305 (10%)

Query: 4 VKTFALAATAIAATMSAPTFAADRSDLRSGDYSWMQFNAMYAVNELPRSDADDGGHDYLE 63
+K LAA A+ A + A +D W + + R YLE
Sbjct: 1 MKKTLLAAGAVVALSTTFAAGAAENDKPQYLSDWWHQSVNVVGSYHTRFGPQIRNDTYLE 60

Query: 64 MEFGGRAGIVDLYGYVDVFNLANSSSGDKG--AGKSKMFMKFAPRFSIDAMTGWDLSAGP 121
E + D YGY+D +S KG S +FM+ PRFSID +T DLS GP
Sbjct: 61 YEAFAKKDWFDFYGYIDAPVFFGGNSTAKGIWNKGSPLFMEIEPRFSIDKLTNTDLSFGP 120

Query: 122 IQEVYFSTLFNWGGGAISGVDADGNEHGGDVNMSFWGLGADVMVPWLGKTGMNLYATYD- 180
+E YF+ + + G + + + GLG D+ +N+YA Y
Sbjct: 121 FKEWYFANNYIYDM---------GRNDSQEQSTWYMGLGTDIDTGLPMSLSLNVYAKYQW 171

Query: 181 -----MNAKDWNGYQFSMNWFKPVMNFDNGSFVSFQGYVDYQFGADAVDDMYVPTT---- 231
N +W+GY+F + +F P+ + GS +S+ G+ ++ +G+D DD +
Sbjct: 172 QNYGASNENEWDGYRFKVKYFVPLTDLWGGS-LSYIGFTNFDWGSDLGDDNFYDLNGKHA 230

Query: 232 -------SSGGAAYFGLHWHSDNYALGY--GLKAYQDVYLVKDDGGIVGLESTGFAHYFT 282
SS A HWH A + G + D L DG + STG+ YF
Sbjct: 231 RTSNSIASSHILALNYAHWHYSIVARYFHNGGQWADDAKLNFGDGPF-SVRSTGWGGYFV 289

Query: 283 ATYKF 287
Y F
Sbjct: 290 VGYNF 294


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3052BINARYTOXINB260.026 Binary toxin B family signature.
		>BINARYTOXINB#Binary toxin B family signature.

Length = 764

Score = 25.8 bits (56), Expect = 0.026
Identities = 11/54 (20%), Positives = 15/54 (27%), Gaps = 9/54 (16%)

Query: 8 WHQYIQWCDSM---------GLTPENRRSCAPRLTDPELKPAPKFKLAPELESA 52
W + + L RR A +DP P L L+ A
Sbjct: 506 WSEVLPQIQETTARIIFNGKDLNLVERRIAAVNPSDPLETTKPDMTLKEALKIA 559


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3053TCRTETOQM2032e-60 Tetracycline resistance protein TetO/TetQ/TetM family ...
		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

signature.
Length = 639

Score = 203 bits (519), Expect = 2e-60
Identities = 107/460 (23%), Positives = 209/460 (45%), Gaps = 45/460 (9%)

Query: 10 KRRTFAIISHPDAGKTTITEKVLLFGNALQKAGTV-KGKKSGQHAKSDWMEMEKDRGISI 68
K +++H DAGKTT+TE +L A+ + G+V KG ++D +E+ RGI+I
Sbjct: 2 KIINIGVLAHVDAGKTTLTESLLYNSGAITELGSVDKGT-----TRTDNTLLERQRGITI 56

Query: 69 TTSVMQFPYSDALVNLLDTPGHEDFSEDTYRTLTAVDSCLMVIDSAKGVEQRTIKLMEVT 128
T + F + + VN++DTPGH DF + YR+L+ +D +++I + GV+ +T L
Sbjct: 57 QTGITSFQWENTKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHAL 116

Query: 129 RLRDTPIVTFMNKLDRDIRDPIELMDEVEEVLNIKCAPITWPIGAGKEFKGVYHLLRDEV 188
R P + F+NK+D++ D + +++E L+ + + +V
Sbjct: 117 RKMGIPTIFFINKIDQNGIDLSTVYQDIKEKLSAEIVI------------------KQKV 158

Query: 189 ILYQGGMGHTIQDSRVIKGLDNPELDEAIGSYAAEIRDEMELVVGASHEFDHQQFLKGEL 248
LY +S + D+ + Y + E + + + +F L
Sbjct: 159 ELYPNMCVTNFTESEQWDTVIEGN-DDLLEKYMSGKSLEALEL----EQEESIRFHNCSL 213

Query: 249 TPVYFGTALGNFGVDHILDGIVEWAPVPQPRETEIREVQPEEEKFSGFVFKIQANMDPKH 308
PVY G+A N G+D++++ I R + + G VFKI+ K
Sbjct: 214 FPVYHGSAKNNIGIDNLIEVITNKFYSSTHR---------GQSELCGKVFKIE--YSEK- 261

Query: 309 RDRVAFMRICSGRYEQGMKMHHVRLGKDVNVSDALTFMAGDRNRAEAAYPGDIIGLHNHG 368
R R+A++R+ SG + K + +++ T + G+ + + AY G+I+ L N
Sbjct: 262 RQRLAYIRLYSGVLHLRDSVRISEKEK-IKITEMYTSINGELCKIDKAYSGEIVILQNEF 320

Query: 369 TIRIGDTFTQGEKLRFTGVPNFAPEMFR-RIRLKDPLKQKQLLKGLVQLSEEG-AVQVFR 426
+++ + L + + + P +++ LL L+++S+ ++ +
Sbjct: 321 -LKLNSVLGDTKLLPQRERIENPLPLLQTTVEPSKPQQREMLLDALLEISDSDPLLRYYV 379

Query: 427 PLDSNDLIVGAVGVLQFEVVVGRLKTEYKVEAIYEAISVA 466
++++I+ +G +Q EV L+ +Y VE + +V
Sbjct: 380 DSATHEIILSFLGKVQMEVTCALLQEKYHVEIEIKEPTVI 419


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3055RTXTOXIND330.004 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 32.9 bits (75), Expect = 0.004
Identities = 35/192 (18%), Positives = 63/192 (32%), Gaps = 27/192 (14%)

Query: 497 VAGTRDGITALQMDIKIEGITKEIMQIALKQAYGARVHILDVMDRAISGHRGDISEHAPR 556
I + ++E + L + A+ +L+ + ++ + +
Sbjct: 216 RLTVLARINRYENLSRVEKSRLDDFSSLLHKQAIAKHAVLE-QENKYVEAVNELRVYKSQ 274

Query: 557 ITTIKINPEKIRDVIGKGGATIRALTEETGTTIELDD--DGTVKIASSNGEATK-EAIRR 613
+ E+I I + +T+ I LD T I E K E ++
Sbjct: 275 L-------EQIESEILSAKEEYQLVTQLFKNEI-LDKLRQTTDNIGLLTLELAKNEERQQ 326

Query: 614 IEEITAEVEVGTVYNGKVVRIVDFGAFVT-------ILPGKDGLVHISQIAEERVANVSD 666
I A V V KV G VT I+P D L + + + +
Sbjct: 327 ASVIRAPVS-VKVQQLKVHTE---GGVVTTAETLMVIVPEDDTLEVTALVQNKDI----G 378

Query: 667 YLEVGQEVKVKV 678
++ VGQ +KV
Sbjct: 379 FINVGQNAIIKV 390


86Spea_3060Spea_3071N        Y        YPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_30603320.145173translation initiation factor IF-2
Spea_3061121-0.111290transcription elongation factor NusA
Spea_30621180.228686hypothetical protein
Spea_30631170.603592**preprotein translocase subunit SecG
Spea_30641160.546728triosephosphate isomerase
Spea_30650150.525107phosphoglucosamine mutase
Spea_3066-1130.469734dihydropteroate synthase
Spea_3067-1120.534506ATP-dependent metalloprotease FtsH
Spea_3068-2120.09543123S rRNA methyltransferase J
Spea_30690170.587674hypothetical protein
Spea_30701170.467082protein-export membrane protein SecF
Spea_30711180.790073preprotein translocase subunit SecD
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3060TCRTETOQM742e-15 Tetracycline resistance protein TetO/TetQ/TetM family ...
		>TCRTETOQM#Tetracycline resistance protein TetO/TetQ/TetM family

signature.
Length = 639

Score = 73.7 bits (181), Expect = 2e-15
Identities = 69/279 (24%), Positives = 102/279 (36%), Gaps = 80/279 (28%)

Query: 403 IMGHVDHGKTSLLDYI-----RRAKVASGEAG-------------GITQHIGAYHVETEN 444
++ HVD GKT+L + + ++ S + G GIT G + EN
Sbjct: 8 VLAHVDAGKTTLTESLLYNSGAITELGSVDKGTTRTDNTLLERQRGITIQTGITSFQWEN 67

Query: 445 GMITFLDTPGHAAFTAMRARGAKATDIVILVVAADDGVMPQTIEAIQHAKAGGVPLIVAV 504
+ +DTPGH F A R D IL+++A DGV QT + G+P I +
Sbjct: 68 TKVNIIDTPGHMDFLAEVYRSLSVLDGAILLISAKDGVQAQTRILFHALRKMGIPTIFFI 127

Query: 505 NKIDKPEADPDRV----KSELSQHGVM-----------------SEDWG----GNNMFV- 538
NKID+ D V K +LS V+ SE W GN+ +
Sbjct: 128 NKIDQNGIDLSTVYQDIKEKLSAEIVIKQKVELYPNMCVTNFTESEQWDTVIEGNDDLLE 187

Query: 539 ------------------------------HVSAKDGTGIDELLEGILLEAEVLELQAVR 568
H SAK+ GID L+E I + +
Sbjct: 188 KYMSGKSLEALELEQEESIRFHNCSLFPVYHGSAKNNIGIDNLIEVITNKF----YSSTH 243

Query: 569 EGMA--AGVVVESKLDKGRGPVATVLVQEGTLKQGDIVL 605
G + G V + + + R +A + + G L D V
Sbjct: 244 RGQSELCGKVFKIEYSEKRQRLAYIRLYSGVLHLRDSVR 282


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3063SECGEXPORT1228e-40 Protein-export SecG membrane protein signature.
		>SECGEXPORT#Protein-export SecG membrane protein signature.

Length = 110

Score = 122 bits (308), Expect = 8e-40
Identities = 67/112 (59%), Positives = 83/112 (74%), Gaps = 3/112 (2%)

Query: 1 MYEVLMVVYLLVSIGLVGLILIQQGKGADMGASFGAGASGTLFGSSGSGNFLTRSTAILA 60
MYE L+VV+L+V+IGLVGLI++QQGKGADMGASFGAGAS TLFGSSGSGNF+TR TA+LA
Sbjct: 1 MYEALLVVFLIVAIGLVGLIMLQQGKGADMGASFGAGASATLFGSSGSGNFMTRMTALLA 60

Query: 61 VAFFALSLTIGNLSANHTKAEGAWDDLGSDAAQVVEQVQQEA-EKSEDKIPD 111
FF +SL +GN+++N T W++L A EQ Q A K IP+
Sbjct: 61 TLFFIISLVLGNINSNKTNKGSEWENL--SAPAKTEQTQPAAPAKPTSDIPN 110


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3064adhesinb330.001 Adhesin B signature.
		>adhesinb#Adhesin B signature.

Length = 310

Score = 32.5 bits (74), Expect = 0.001
Identities = 18/95 (18%), Positives = 34/95 (35%), Gaps = 16/95 (16%)

Query: 142 REARRTFEVIAEELDVVIEKNGTMAFDNAIIAY----EPLWAVGTGKSATPEQAQEVHAF 197
+EA+ F I E +++ G F AY +W + T + TP+Q + +
Sbjct: 186 KEAKEKFNNIPGEKKMIVTSEG--CFKYFSKAYNVPSAYIWEINTEEEGTPDQIKTLVEK 243

Query: 198 IRKRLSEVSPFIGENIRILYGGSVTPSNAADLFAQ 232
+RK + L+ S ++
Sbjct: 244 LRKT----------KVPSLFVESSVDDRPMKTVSK 268


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3067HTHFIS365e-04 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 35.6 bits (82), Expect = 5e-04
Identities = 22/82 (26%), Positives = 31/82 (37%), Gaps = 18/82 (21%)

Query: 193 VLLVGPPGTGKTLLAKAI---AGEAKVPFFT-----ISGSDFVEMFVGV------GASRV 238
+++ G GTGK L+A+A+ PF I G GA
Sbjct: 163 LMITGESGTGKELVARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQTR 222

Query: 239 RD-MFEQAKKSAPCIIFIDEID 259
FEQA+ +F+DEI
Sbjct: 223 STGRFEQAEGGT---LFLDEIG 241


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3070SECFTRNLCASE2348e-78 Bacterial translocase SecF protein signature.
		>SECFTRNLCASE#Bacterial translocase SecF protein signature.

Length = 333

Score = 234 bits (598), Expect = 8e-78
Identities = 88/302 (29%), Positives = 150/302 (49%), Gaps = 18/302 (5%)

Query: 14 KARYLSSVFSLLIMLASIGIILTNGFNLGLDFTGGVVTEVKLDPNIKAAQISELLGKDSQ 73
+ ++ + ++++M+AS+ + L G N G+DF GG + I L
Sbjct: 18 RWQWATFGAAIVMMIASVILPLVIGLNFGIDFKGGTTIRTESTTAIDVGVYRAALEPLEL 77

Query: 74 QEVSV------------------ISAGEPGRWVLRYAKVDDVSGADIRTVLAPLTNQVEV 115
+V + I E G+ + T L + +++
Sbjct: 78 GDVIISEVRDPSFREDQHVAMIRIQMQEDGQGAEGQGAQGQELVNKVETALTAVDPALKI 137

Query: 116 LNSSIVGPQIGQELAEQGGLALLAAMLCILGYLSFRFEWRLASGALLALFHDVIFVLAFF 175
+ VGP++ EL +LLAA + I+ Y+ RFEW+ A GA++AL HDV+ + F
Sbjct: 138 TSFESVGPKVSGELVWTAVWSLLAATVVIMFYIWVRFEWQFALGAVVALVHDVLLTVGLF 197

Query: 176 SLTQMEFNLTILAAVLAILGYSLNDSIVIADRVREVLIAKPKAAIDEICSSAVQATFSRT 235
++ Q++F+LT +AA+L I GYS+ND++V+ DR+RE LI + ++ + +V T SRT
Sbjct: 198 AVLQLKFDLTTVAALLTITGYSINDTVVVFDRLRENLIKYKTMPLRDVMNLSVNETLSRT 257

Query: 236 MVTSGTTLFTVAALWIMGGAPLQGFSIAMFLGILIGTISSVSVGTCLPEYLKVSAEHYKV 295
++T TTL + + I GG ++GF AM G+ GT SSV V + ++ + K
Sbjct: 258 VMTGMTTLLALVPMLIWGGDVIRGFVFAMVWGVFTGTYSSVYVAKNIVLFIGLDRNKEKK 317

Query: 296 EP 297
+P
Sbjct: 318 DP 319


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3071SECFTRNLCASE832e-19 Bacterial translocase SecF protein signature.
		>SECFTRNLCASE#Bacterial translocase SecF protein signature.

Length = 333

Score = 82.6 bits (204), Expect = 2e-19
Identities = 35/174 (20%), Positives = 81/174 (46%), Gaps = 4/174 (2%)

Query: 422 VTIVEERTIGPSLGEENITNGFSALALGMGVTLLFMGLWYR-RLGWIANVALVANMILIF 480
+ I ++GP + E + +L V + ++ + + + A VALV +++L
Sbjct: 135 LKITSFESVGPKVSGELVWTAVWSLLAATVVIMFYIWVRFEWQFALGAVVALVHDVLLTV 194

Query: 481 GLMALIPGAVLTLPGIAGLVLTVGMAVDTNVLIFERIKDKLK--EGRSFAHAIDRGFDSA 538
GL A++ L +A L+ G +++ V++F+R+++ L + ++ +
Sbjct: 195 GLFAVL-QLKFDLTTVAALLTITGYSINDTVVVFDRLRENLIKYKTMPLRDVMNLSVNET 253

Query: 539 FSTIVDANFTTMITAVVLYAIGNGPIQGFALTLGLGLLTSMFTGIFASRALVNW 592
S V TT++ V + G I+GF + G+ T ++ ++ ++ +V +
Sbjct: 254 LSRTVMTGMTTLLALVPMLIWGGDVIRGFVFAMVWGVFTGTYSSVYVAKNIVLF 307


87Spea_3353Spea_3368N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_33530181.065027hypothetical protein
Spea_33540160.184617UspA domain-containing protein
Spea_3355-1151.122012UspA domain-containing protein
Spea_3356-2151.039736hypothetical protein
Spea_3357-2161.071811aldehyde dehydrogenase
Spea_3358-2181.111212TetR family transcriptional regulator
Spea_3360-2181.947112PAS/PAC sensor signal transduction histidine
Spea_3361-3172.484326Fis family two component sigma54 specific
Spea_3362-2171.767701hypothetical protein
Spea_3363-2152.626302hypothetical protein
Spea_3364-1162.757066ABC transporter-like protein
Spea_3365-1172.785337RND family efflux transporter MFP subunit
Spea_33660182.431835porin
Spea_33670192.167545response regulator receiver protein
Spea_33680212.304951flavocytochrome c
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3353BONTOXILYSIN280.039 Bontoxilysin signature.
		>BONTOXILYSIN#Bontoxilysin signature.

Length = 1196

Score = 27.6 bits (61), Expect = 0.039
Identities = 10/25 (40%), Positives = 15/25 (60%), Gaps = 1/25 (4%)

Query: 31 QWWIK-DAEFDELIKQRYASLLAQA 54
QWW + +++ ELI S+LAQ
Sbjct: 671 QWWTEYYSQYFELICMAKQSILAQE 695


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3355SHAPEPROTEIN260.046 Bacterial cell shape determinant MreB/Mbl protein s...
		>SHAPEPROTEIN#Bacterial cell shape determinant MreB/Mbl protein

signature.
Length = 347

Score = 26.3 bits (58), Expect = 0.046
Identities = 10/39 (25%), Positives = 18/39 (46%), Gaps = 5/39 (12%)

Query: 6 ILCPTDFSDTASHALKYAIEMANLYHVGLRIVHVIEQPM 44
+ P + A++ + + A G R V +IE+PM
Sbjct: 112 VCVPVGATQVERRAIRESAQGA-----GAREVFLIEEPM 145


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3358HTHTETR674e-16 TetR bacterial regulatory protein HTH signature.
		>HTHTETR#TetR bacterial regulatory protein HTH signature.

Length = 215

Score = 67.0 bits (163), Expect = 4e-16
Identities = 29/149 (19%), Positives = 56/149 (37%), Gaps = 11/149 (7%)

Query: 3 RIDKKQAILDTALTLFVSQGFYATSTASIAKQAGVATGTLFHHFASKEALMNHLYISIKQ 62
+ +Q ILD AL LF QG +TS IAK AGV G ++ HF K L + ++ +
Sbjct: 9 AQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSES 68

Query: 63 EFADGIQSQISQKGD-----LEKDAQHLWQVAINWA----MANPLKQEFFQQYSMSPSIA 113
+ ++ L + H+ + + + + + M+
Sbjct: 69 NIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQ- 127

Query: 114 SQVRQQAMNSILGFMGELIHQGQKAGVLA 142
Q ++ + + + +A +L
Sbjct: 128 -QAQRNLCLESYDRIEQTLKHCIEAKMLP 155


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3361HTHFIS425e-147 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 425 bits (1095), Expect = e-147
Identities = 155/513 (30%), Positives = 251/513 (48%), Gaps = 48/513 (9%)

Query: 3 TILIVDDNQAVCNALALMLELSGYQTLTCLSPDVALELIRLHDVALVIQDMNFTQDTTSG 62
TIL+ DD+ A+ L L +GY + I D LV+ D+
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVM-----PD 59

Query: 63 EEGRNLFYGFRQLQPELPIILLTAWTQLELAVELVKEGAADYMGKPWDDAKLLNSISNLI 122
E +L ++ +P+LP+++++A A++ ++GA DY+ KP+D +L+ I +
Sbjct: 60 ENAFDLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRAL 119

Query: 123 SLHRLSKKNAQLSRVESQRMVAIKDAELCGIVFNSGAMQRCVDLALQIAKSDVSVLITGP 182
+ + + + +V S AMQ + ++ ++D++++ITG
Sbjct: 120 AEPKRRPSKLEDDSQDGM-----------PLVGRSAAMQEIYRVLARLMQTDLTLMITGE 168

Query: 183 NGAGKDKLADIIHANSPLRYKPFIKVNIGALPMDLLEAELFGAEAGAYTGATKARIGRFE 242
+G GK+ +A +H R PF+ +N+ A+P DL+E+ELFG E GA+TGA GRFE
Sbjct: 169 SGTGKELVARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQTRSTGRFE 228

Query: 243 AADGGTLFLDEIGNLPLSGQVKLLRVLQTGEFERLGSHQTRRVNVRVVSATNADLAQDIQ 302
A+GGTLFLDEIG++P+ Q +LLRVLQ GE+ +G R +VR+V+ATN DL Q I
Sbjct: 229 QAEGGTLFLDEIGDMPMDAQTRLLRVLQQGEYTTVGGRTPIRSDVRIVAATNKDLKQSIN 288

Query: 303 AGRFREDLFYRLNVIELALPALNERKDDVLPLVEHFI-------GTDFSLLRQTQQALVA 355
G FREDL+YRLNV+ L LP L +R +D+ LV HF+ ++ + + A
Sbjct: 289 QGLFREDLYYRLNVVPLRLPPLRDRAEDIPDLVRHFVQQAEKEGLDVKRFDQEALELMKA 348

Query: 356 HSWPGNVRELENACKRAVILANSPELTVEDFGLVIHTSMAEPVSTSATNDATNPVTSSVT 415
H WPGNVRELEN +R L +T E + + + + A + + S
Sbjct: 349 HPWPGNVRELENLVRRLTALYPQDVITREIIENELRSEIPDSPIEKAAARSGSLSIS--- 405

Query: 416 NFVAGALVEKSASPQTQTYASAKHSSAEPMSNPEASNNESSNTEQSCTETPQAEKANIEA 475
+ + + + ++ + S ++ + E I A
Sbjct: 406 -------------------QAVEENMRQYFASFGDALPPSGLYDRV---LAEMEYPLILA 443

Query: 476 ALDQHRGVIARVAKALGLSRQALYRRMDKYGID 508
AL RG + A LGL+R L +++ + G+
Sbjct: 444 ALTATRGNQIKAADLLGLNRNTLRKKIRELGVS 476


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3365RTXTOXIND415e-06 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 41.4 bits (97), Expect = 5e-06
Identities = 47/379 (12%), Positives = 118/379 (31%), Gaps = 104/379 (27%)

Query: 18 SKIKRPLMFGLAALLVSGLVWSSMDRDSIATSIKRSELRFATLERGTLIRDIPTTGKIVA 77
S+ R + + + LV + S +E GK+
Sbjct: 54 SRRPRLVAYFIMGFLVIAFILSV----------------LGQVEIV-----ATANGKLTH 92

Query: 78 A-NAPVLYSPEQGSVTLIA-KPGDKVELGEVVATI-------ESHKLTNSL---KQQQAV 125
+ + + E V I K G+ V G+V+ + ++ K +SL + +Q
Sbjct: 93 SGRSKEIKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTR 152

Query: 126 LEGMKSSLERARLDA-------------------------------RRQQLKAQQTLDMA 154
+ + S+E +L + Q+ + + LD
Sbjct: 153 YQILSRSIELNKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKK 212

Query: 155 KVDLEAADRESRRGDQ--------------LIESKLISKIDFEKSKDDLHKAKL-LFAHA 199
+ + R + L+ + I+K + ++ +A L +
Sbjct: 213 RAERLTVLARINRYENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYK 272

Query: 200 GQEALLMKDTLTFELKNTSLEVDRQALVVKEL-----------------ERQVAALNIIA 242
Q + + L+ + + + + ++ +L E + A I A
Sbjct: 273 SQLEQIESEILSAKEEYQLVTQLFKNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRA 332

Query: 243 PVAGIIGNW-LTEQKARIGQSQPILTVV-DLSAFEAELAVPESYADELGIGMVVELSFGS 300
PV+ + + + + ++ ++ +V + E V + +G + +
Sbjct: 333 PVSVKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEA 392

Query: 301 ------EKVMGELSSISPE 313
++G++ +I+ +
Sbjct: 393 FPYTRYGYLVGKVKNINLD 411


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3366ECOLIPORIN921e-22 E.coli/Salmonella-type porin signature.
		>ECOLIPORIN#E.coli/Salmonella-type porin signature.

Length = 383

Score = 91.5 bits (227), Expect = 1e-22
Identities = 109/416 (26%), Positives = 172/416 (41%), Gaps = 64/416 (15%)

Query: 1 MNKKLLALLIPSILIAGSAQAVEIYNDQTNSINMMGWL-GFAAINDTHDTAVVDNFSRVG 59
M +K+LAL+IP++L AG+A A EIYN N +++ G + G +D + RVG
Sbjct: 1 MKRKVLALVIPALLAAGAAHAAEIYNKDGNKLDLYGKVDGLHYFSDDSSKDGDQTYMRVG 60

Query: 60 FRFDRQEKNGWRSFAHTEWGINMVTSDDSLSYSGGQLGAEKNSDFLFNRLGYVGLANDKW 119
F+ + Q + + E Y+ E + RL + GL +
Sbjct: 61 FKGETQINDQLTGYGQWE-------------YNVQANTTEGEGANSWTRLAFAGLKFGDY 107

Query: 120 GSLTFGKQWGVYYDVAYTTDVLNVYTGYSVGAYTFGDGGLTGAGRADSAFVYRNS--FG- 176
GS +G+ +GV YDV TD+L + G S YT+ D +T GRA+ YRN+ FG
Sbjct: 108 GSFDYGRNYGVLYDVEGWTDMLPEFGGDS---YTYADNYMT--GRANGVATYRNTDFFGL 162

Query: 177 --NLSIALQYAAK-QNGDVALYDKDGIALDDGSHVEFDT--SYGASLTYHFTDKFKVLAG 231
L+ ALQY K ++ + ++G + +D +G S TY F A
Sbjct: 163 VDGLNFALQYQGKNESQSADDVNIGTNNRNNGDDIRYDNGDGFGISTTYDIGMGFSAGAA 222

Query: 232 INRGDFTGELAGERVD----------------DTNEIIGVGAQYGSFYQYAPNREADGFY 275
D T E D N I + Y P + D Y
Sbjct: 223 YTTSDRTNEQVNAGGTIAGGDKADAWTAGLKYDANNIY-LATMYSETRNMTPYGKTDKGY 281

Query: 276 VGFNAHKSKQNELVAGELYDSTGSEFLIAYQYENGFVPS--FLLSY-QDLDTDASTTIQG 332
G A+K++ E+ A YQ++ G P+ FL+S +DL +
Sbjct: 282 DGGVANKTQNFEVTA-------------QYQFDFGLRPAVSFLMSKGKDLTYNNVNGDDK 328

Query: 333 DWTRQFAVLGLHYRYSNDTVMFAEAKIDFSDMDDKSFENL---QDNSYAVGIRYFF 385
D + V G Y ++ + + + KI+ D DD +++ D+ A+G+ Y F
Sbjct: 329 DLVKYADV-GATYYFNKNFSTYVDYKINLLDDDDPFYKDAGISTDDIVALGMVYQF 383


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3367HTHFIS366e-124 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 366 bits (940), Expect = e-124
Identities = 130/364 (35%), Positives = 197/364 (54%), Gaps = 29/364 (7%)

Query: 168 RANQALSLENDSLKRAMFCPDGVVGAEGGLKKVMVQVDAIAALNTSVLMQGETGCGKEVI 227
RA L+ +VG ++++ + + + ++++ GE+G GKE++
Sbjct: 117 RALAEPKRRPSKLEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELV 176

Query: 228 ANAIHAKSNRAGKPFIKVNCGAIPETLIDSELFGYEKGAFTGAETRKAGYFEQANGGTIF 287
A A+H R PF+ +N AIP LI+SELFG+EKGAFTGA+TR G FEQA GGT+F
Sbjct: 177 ARALHDYGKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQTRSTGRFEQAEGGTLF 236

Query: 288 LDEIGELPLSAQVRLLRVLQNSSITRVGGYENVDLDIRVIAATHRNLQAMVHEKTFREDL 347
LDEIG++P+ AQ RLLRVLQ T VGG + D+R++AAT+++L+ +++ FREDL
Sbjct: 237 LDEIGDMPMDAQTRLLRVLQQGEYTTVGGRTPIRSDVRIVAATNKDLKQSINQGLFREDL 296

Query: 348 WYRLAVFPIDIPALRQRRSDIPLLVQHFIEMLAAKFNLEKLPRVMPEQLSILNNYSWPGN 407
+YRL V P+ +P LR R DIP LV+HF++ A K L+ + R E L ++ + WPGN
Sbjct: 297 YYRLNVVPLRLPPLRDRAEDIPDLVRHFVQ-QAEKEGLD-VKRFDQEALELMKAHPWPGN 354

Query: 408 VRELINVLERAIIQKPRGPLTFDLLQAQSDEEVTTKAGQTIIVDPSHASDKLVP------ 461
VREL N++ R P+ +T ++++ + E+ + S
Sbjct: 355 VRELENLVRRLTALYPQDVITREIIENELRSEIPDSPIEKAAARSGSLSISQAVEENMRQ 414

Query: 462 ------------------LETMISKYISHAMRITGGKLYGPGGAAELLDINPNTLKSKMK 503
L M I A+ T G AA+LL +N NTL+ K++
Sbjct: 415 YFASFGDALPPSGLYDRVLAEMEYPLILAALTATRGNQ---IKAADLLGLNRNTLRKKIR 471

Query: 504 KLGL 507
+LG+
Sbjct: 472 ELGV 475


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3368BICOMPNTOXIN290.036 Staphylococcal bi-component toxin signature.
		>BICOMPNTOXIN#Staphylococcal bi-component toxin signature.

Length = 315

Score = 29.1 bits (65), Expect = 0.036
Identities = 12/57 (21%), Positives = 26/57 (45%), Gaps = 2/57 (3%)

Query: 332 FFNELADRKARADAIMTRRDEQGKPVYPIGFTNAEGAKDAQTLAWGLKYNVIKKADN 388
F+ + D+K DA++ + QG + N + + + W +YN+ K ++
Sbjct: 63 QFDFVKDKKYNKDALILK--MQGFISSRTTYYNYKKTNHVKAMRWPFQYNIGLKTND 117


88Spea_3577Spea_3582N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_3577-190.928796two component transcriptional regulator
Spea_3578-1110.755909LuxR family transcriptional regulator
Spea_35790131.325729hypothetical protein
Spea_35800151.031013alanine racemase
Spea_35812210.712258replicative DNA helicase
Spea_35824220.251245hypothetical protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3577HTHFIS771e-18 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 77.2 bits (190), Expect = 1e-18
Identities = 27/124 (21%), Positives = 57/124 (45%), Gaps = 1/124 (0%)

Query: 3 VLLVEDNRLLAKNIIQYLELNEIECDYAETLERAEERIFSSTFDAIILDLNLPDGDGITA 62
+L+ +D+ + + Q L + I + D ++ D+ +PD +
Sbjct: 6 ILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFDL 65

Query: 63 CQRWKEQCIMAPIIMLTARSNLQDRLSGFEAGADDYLVKPFALAELVARL-KVVSQRRPS 121
R K+ P+++++A++ + E GA DYL KPF L EL+ + + +++ +
Sbjct: 66 LPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKRR 125

Query: 122 PKRL 125
P +L
Sbjct: 126 PSKL 129


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3578PF06580290.025 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 28.7 bits (64), Expect = 0.025
Identities = 27/136 (19%), Positives = 44/136 (32%), Gaps = 18/136 (13%)

Query: 74 VFSSSPTVKQLHQQYVTRVAPTDINFAAALRLDSPYHYVLCE---DGQPTKVQKLFNSHG 130
+K Q + RV P + + + + L L S
Sbjct: 62 FIKRQGWLKLNMGQIILRVLPACVVIGMVWFVANTSIWRLLAFINTKPVAFTLPLALSII 121

Query: 131 INTVL---SWPLKHFASDTWSGRFTLLSKYPYEELRLTELEQTLKQAQLTIFEHFHNEIN 187
N V+ W L +F + Y E+ ++ ++AQL +IN
Sbjct: 122 FNVVVVTFMWSLLYFG-------WHFFKNYKQAEIDQWKMASMAQEAQL---MALKAQIN 171

Query: 188 PYRQYNLFNQTAIRAL 203
P+ +N N IRAL
Sbjct: 172 PHFMFNALN--NIRAL 185


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3580ALARACEMASE436e-156 Alanine racemase signature.
		>ALARACEMASE#Alanine racemase signature.

Length = 356

Score = 436 bits (1124), Expect = e-156
Identities = 149/350 (42%), Positives = 213/350 (60%), Gaps = 6/350 (1%)

Query: 6 RAEISRHALKNNLARLHELAPSSKVMAVVKANGYGHGLLNVAQCLDNADGFGLARLEEAL 65
+A + ALK NL+ + + A ++V +VVKAN YGHG+ + + DGF L LEEA+
Sbjct: 6 QASLDLQALKQNLSIVRQAATHARVWSVVKANAYGHGIERIWSAIGATDGFALLNLEEAI 65

Query: 66 ALRAGGVKAKLLLLEGFFRATDLVTLVEHDIETVVHHESQIEMLEQAELNKPVTVWMKVD 125
LR G K +L+LEGFF A DL +H + T VH Q++ L+ A L P+ +++KV+
Sbjct: 66 TLRERGWKGPILMLEGFFHAQDLEIYDQHRLTTCVHSNWQLKALQNARLKAPLDIYLKVN 125

Query: 126 SGMHRLGFVPDEFHQIYQRLLACDNIAKPINLMTHFACADEPDNDCTAKQIAVFEELTKD 185
SGM+RLGF PD ++Q+L A N+ + LM+HFA A+ PD + +A E+ +
Sbjct: 126 SGMNRLGFQPDRVLTVWQQLRAMANV-GEMTLMSHFAEAEHPDG--ISGAMARIEQAAEG 182

Query: 186 LLGDRTLANSAGALFWQQSQASWIRPGIALYGVSPVVGDLGT--KHGLIPAMELVSQLIA 243
L R+L+NSA L+ ++ W+RPGI LYG SP G GL P M L S++I
Sbjct: 183 LECRRSLSNSAATLWHPEAHFDWVRPGIILYGASPS-GQWRDIANTGLRPVMTLSSEIIG 241

Query: 244 IRDHKAGQPVGYGSHWVAEKDTKLGVVAIGYGDGYPRNAPLGTPVLINGRLAPIVGRVSM 303
++ KAG+ VGYG + A + ++G+VA GY DGYPR+AP GTPVL++G VG VSM
Sbjct: 242 VQTLKAGERVGYGGRYTARDEQRIGIVAAGYADGYPRHAPTGTPVLVDGVRTMTVGTVSM 301

Query: 304 DMLTVDLGAGAKDNVGDKAVLWGKDLPVEEVAEHIGTIAYELVTKLTPRV 353
DML VDL + +G LWGK++ +++VA GT+ YEL+ L RV
Sbjct: 302 DMLAVDLTPCPQAGIGTPVELWGKEIKIDDVAAAAGTVGYELMCALALRV 351


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3582V8PROTEASE487e-08 V8 serine protease family signature.
		>V8PROTEASE#V8 serine protease family signature.

Length = 336

Score = 48.1 bits (114), Expect = 7e-08
Identities = 17/51 (33%), Positives = 26/51 (50%), Gaps = 1/51 (1%)

Query: 661 SVPVNFLS-SVDTTGGNSGSPVFNGKGELVGLNFDSTYEAITKDWFFNPTI 710
+ + + TTGGNSGSPVFN K E++G+++ F N +
Sbjct: 220 YLKGEAMQYDLSTTGGNSGSPVFNEKNEVIGIHWGGVPNEFNGAVFINENV 270


89Spea_3691Spea_3696N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_3691-1284.509451MATE efflux family protein
Spea_36920253.779100pentapeptide repeat-containing protein
Spea_36930243.506070hypothetical protein
Spea_3694-1243.244051LysR family transcriptional regulator
Spea_3695-1233.052073RND family efflux transporter MFP subunit
Spea_36960213.565915acriflavin resistance protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3691SECFTRNLCASE300.015 Bacterial translocase SecF protein signature.
		>SECFTRNLCASE#Bacterial translocase SecF protein signature.

Length = 333

Score = 30.2 bits (68), Expect = 0.015
Identities = 25/140 (17%), Positives = 60/140 (42%), Gaps = 15/140 (10%)

Query: 169 MMLAALINLILDPLLIFGIGPFPRLEIEGAAIATVISWVVALSLSTHLLIFKRHLVDFVE 228
L A++ L+ D LL G+ +L+ + +A +++ + S++ +++F R +
Sbjct: 178 FALGAVVALVHDVLLTVGLFAVLQLKFDLTTVAALLT-ITGYSINDTVVVFDR-----LR 231

Query: 229 PNIKRLKCNWKQLAHIAQPAAMMNLLNPLANAIIMAMLARIDHSAVAAFGAGT--RLESV 286
N+ + K L + +++ L+ ++ M + + +G
Sbjct: 232 ENLIKYK--TMPLRDVMN----LSVNETLSRTVMTGMTTLLALVPMLIWGGDVIRGFVFA 285

Query: 287 MLIAVMALSSSLVPFVAQNL 306
M+ V + S V +VA+N+
Sbjct: 286 MVWGVFTGTYSSV-YVAKNI 304


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3692NUCEPIMERASE310.003 Nucleotide sugar epimerase signature.
		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

Length = 334

Score = 30.9 bits (70), Expect = 0.003
Identities = 21/95 (22%), Positives = 36/95 (37%), Gaps = 8/95 (8%)

Query: 2 HAVDQIFNDEDFSDQDLQDARFERCSFYHCRFNHADLTDAEFIQCKFIVPGEDEGCDF-- 59
H V I N D+ D L+ AR E + +F+ DL D E + F +
Sbjct: 25 HQVVGIDNLNDYYDVSLKQARLELLAQPGFQFHKIDLADREGMTDLFASGHFERVFISPH 84

Query: 60 ----SYATLTSASFKHCNL--SMALFKGARCYGLE 88
Y+ ++ NL + + +G R ++
Sbjct: 85 RLAVRYSLENPHAYADSNLTGFLNILEGCRHNKIQ 119


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3695RTXTOXIND484e-08 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 47.5 bits (113), Expect = 4e-08
Identities = 23/182 (12%), Positives = 64/182 (35%), Gaps = 29/182 (15%)

Query: 104 EADYELAKADFKRKGELLRRELISQAEYDLASAQLKSS--KANLASAQDQLSYTELTAPY 161
E++ AK +++ +L + E++ + L LA +++ + + AP
Sbjct: 279 ESEILSAKEEYQLVTQLFKNEILDK----LRQTTDNIGLLTLELAKNEERQQASVIRAPV 334

Query: 162 DGTVAKISI-DNYQMVQANQPVL-VLQKDSDIDVVIQVPESLASKVTQFNPNAITQPV-V 218
V ++ + +V + ++ ++ +D ++V V + Q +
Sbjct: 335 SVKVQQLKVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFINV------GQNAII 388

Query: 219 RFANDPSSSYAALLKEHATQVTPGT-------QSYEVVFTLPRPA------NMTVLPGMS 265
+ P + Y L+ + + + V+ ++ N+ + GM+
Sbjct: 389 KVEAFPYTRYGYLVGK-VKNINLDAIEDQRLGLVFNVIISIEENCLSTGNKNIPLSSGMA 447

Query: 266 AE 267

Sbjct: 448 VT 449



Score = 34.8 bits (80), Expect = 5e-04
Identities = 18/83 (21%), Positives = 31/83 (37%), Gaps = 7/83 (8%)

Query: 78 EGQQVNKGAVLARLDRRDSQNTLLNREADYELAKADFKRKGELLR-------RELISQAE 130
EG+ V KG VL +L ++ L ++ A+ + R L R EL E
Sbjct: 114 EGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNKLPELKLPDE 173

Query: 131 YDLASAQLKSSKANLASAQDQLS 153
+ + + ++Q S
Sbjct: 174 PYFQNVSEEEVLRLTSLIKEQFS 196


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3696ACRIFLAVINRP488e-158 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 488 bits (1259), Expect = e-158
Identities = 210/1045 (20%), Positives = 439/1045 (42%), Gaps = 45/1045 (4%)

Query: 4 AEYSITHKVISWMFALLLLVGGSISFFSLGQLEFPEFTIKQALVVTAYPGASPEQVEEEV 63
A + I + +W+ A++L++ G+++ L ++P V YPGA + V++ V
Sbjct: 2 ANFFIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDTV 61

Query: 64 TLPLEDALQQLDGIKHITSV-NSAGLSQIEIEIKENYDASELPQVWDEVRRKINDKAVEL 122
T +E + +D + +++S +SAG I + + D +V+ K+ L
Sbjct: 62 TQVIEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTD---PDIAQVQVQNKLQLATPLL 118

Query: 123 PPGVHAPSVIDDFGD---VYGILLNVSGDGYSDRELQNYADF-LRRELVLVDGIKKVTIA 178
P V + + + G + ++ +Y ++ L ++G+ V +
Sbjct: 119 PQEVQQQGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLF 178

Query: 179 GIVNEQVVVEISQQKLNALGLDQNYIYGLINSQNVVSNAGSMLVGDN------RIRIHPT 232
G + + + LN L + + QN AG + I
Sbjct: 179 G-AQYAMRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQ 237

Query: 233 GEFDNVRQMERLIISPPGSAKLIYLGDIAKIYKDTEETPSNIYHASGNKALSIGIAFSSG 292
F N + ++ + ++ L D+A++ + E + I +G A +GI ++G
Sbjct: 238 TRFKNPEEFGKVTLRVNSDGSVVRLKDVARV-ELGGENYNVIARINGKPAAGLGIKLATG 296

Query: 293 VNVVKVGEAVNERMSELNSELPIGMALDTVYDQSKMVDQTVNGFLVNLAESIAIVIGVLL 352
N + +A+ +++EL P GM + YD + V +++ + L E+I +V V+
Sbjct: 297 ANALDTAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMY 356

Query: 353 VFMG-VRSGLLMGLVLLLTILGTFIMMNVLNIELQIISLGALIIALGMLVDNAIVVTEGI 411
+F+ +R+ L+ + + + +LGTF ++ + +++ +++A+G+LVD+AIVV E +
Sbjct: 357 LFLQNMRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENV 416

Query: 412 L-IGIKRGQTRLETAKQVISQTQWPLLGATIIAIIAFAPIGLSDNATGEFCASLFQVLLI 470
+ ++ E ++ +SQ Q L+G ++ F P+ +TG ++
Sbjct: 417 ERVMMEDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFSITIVS 476

Query: 471 SLFISWITAMTLTPFFCNLMFKDGIVSDDENDDPYKGW-------LFGLYRHSLNYAMRF 523
++ +S + A+ LTP C + K EN + GW Y +S+ +
Sbjct: 477 AMALSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVGKILGS 536

Query: 524 RGLTLTLVVAALITSVIGFGYVKNVFFPASNTPMFFVDVWMPEGSDIKATERLLSRIETD 583
G L + + V+ F + + F P + +F + +P G+ + T+++L ++
Sbjct: 537 TGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLDQVTDY 596

Query: 584 LLEQQKTTDTGLVNLTTVIGQG-AQRFVLSYVPEKGYK-AYGQILLEMTDLQALNKYMRL 641
L+ +K + + G AQ +++V K ++ G + M L
Sbjct: 597 YLKNEKANVESVFTVNGFSFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIHRAK--MEL 654

Query: 642 LERELSLKFPEAEYRFKYMENGPSPAAKIEARFFGEDPQVLRQLAAQAETILKAEPTAV- 700
+ P + ++ + G L Q Q + P ++
Sbjct: 655 GKIRDGFVIPFNMPAIVELGTATGFDFELIDQA-GLGHDALTQARNQLLGMAAQHPASLV 713

Query: 701 GVRHNWRNQVTLVRPQLAQAQARETGISKQDLDTALLTNFSGQQIGTYRENSHLLPIIAR 760
VR N + ++ Q +A+ G+S D++ + T G + + + + + +
Sbjct: 714 SVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGRVKKLYVQ 773

Query: 761 APAEERLDAQSIWKLQVWSRDNNTFVPVTQVVSDFSTEWEDPLIMRRDRKRVISVLADPI 820
A A+ R+ + + KL V S N VP + + P + R + + + +
Sbjct: 774 ADAKFRMLPEDVDKLYVRSA-NGEMVPFSAFT-TSHWVYGSPRLERYNGLPSMEIQGEAA 831

Query: 821 NGAD-ETADSVFRKIKADIEAIPLPAGYELEWGGEYETSMEAQESVFSSIPLGYLAMFLI 879
G A ++ + + LPAG +W G + + + + ++ +FL
Sbjct: 832 PGTSSGDAMALMENLASK-----LPAGIGYDWTGMSYQERLSGNQAPALVAISFVVVFLC 886

Query: 880 TVLLFNSVRQPLVIWFTVPLALIGVVSGLLLFDAPFSFMALLGLLSLTGMIIKNGIVLVD 939
L+ S P+ + VPL ++GV+ LF+ ++GLL+ G+ KN I++V+
Sbjct: 887 LAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAILIVE 946

Query: 940 QIN-LELSQGKEAYQAVVDSAVSRVRPVLMAAITTMLGMLPLLSDAFFGS-----MAITI 993
L +GK +A + + R+RP+LM ++ +LG+LPL GS + I +
Sbjct: 947 FAKDLMEKEGKGVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAGSGAQNAVGIGV 1006

Query: 994 IFGLGFASVLTLIVLPVTYTLAFRI 1018
+ G+ A++L + +PV + + R
Sbjct: 1007 MGGMVSATLLAIFFVPVFFVVIRRC 1031


90Spea_3740Spea_3745N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_37400111.755706peptidase U62 modulator of DNA gyrase
Spea_37410132.214810hypothetical protein
Spea_37420133.177163Ig domain-containing protein
Spea_37432194.247998ABC-2 type transporter
Spea_37440194.037866ABC-2 type transporter
Spea_37451183.831951secretion protein HlyD family protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3740FRAGILYSIN300.019 Fragilysin metallopeptidase (M10C) enterotoxin signat...
		>FRAGILYSIN#Fragilysin metallopeptidase (M10C) enterotoxin

signature.
Length = 405

Score = 30.0 bits (67), Expect = 0.019
Identities = 15/64 (23%), Positives = 25/64 (39%), Gaps = 3/64 (4%)

Query: 373 LVKEMGTGLIVTEVMGQGVNTVTGDYSRGAAGFYVENGVILYPVEEITIAGNLKDM---F 429
++E G+ + EV Q + Y+ YV +LY E +G+ K+ F
Sbjct: 232 CLRENGSTIYPNEVSAQMQDAANSVYAVHGLKRYVNFHFVLYTTEYSCPSGDAKEGLEGF 291

Query: 430 QNIL 433
L
Sbjct: 292 TASL 295


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3741BCTERIALGSPD270.043 Bacterial general secretion pathway protein D signa...
		>BCTERIALGSPD#Bacterial general secretion pathway protein D

signature.
Length = 660

Score = 27.2 bits (60), Expect = 0.043
Identities = 17/121 (14%), Positives = 36/121 (29%), Gaps = 14/121 (11%)

Query: 44 SKTQVQKLNLDETLYDNVLKAKTIKINTEAHRRHIQYIGKL--------------MRYVD 89
SK+ + + + D A + + +R I I +L ++Y
Sbjct: 219 SKSALPGSMVANVVADERTNAVLVSGEPNSRQRIIAMIKQLDRQQATQGNTKVIYLKYAK 278

Query: 90 LEELEVAIKNVLNQNSNESARTNVADKTRDQLLAEGDSAVQALIEQHPEFDRQKLRQYIR 149
+L + + + +E ++ + ALI L + I
Sbjct: 279 ASDLVEVLTGISSTMQSEKQAAKPVAALDKNIIIKAHGQTNALIVTAAPDVMNDLERVIA 338

Query: 150 Q 150
Q
Sbjct: 339 Q 339


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3742INTIMIN398e-05 Intimin signature.
		>INTIMIN#Intimin signature.

Length = 939

Score = 39.3 bits (91), Expect = 8e-05
Identities = 51/251 (20%), Positives = 90/251 (35%), Gaps = 28/251 (11%)

Query: 279 NELATTLPLEADKYTVSAGGTFGVTADLATKNDDGSYTRLQTPTSVSFSSSCVSSNSASI 338
N + T+ + ++ V G TAD + DG+ + + + A++
Sbjct: 540 NNVLLTITVLSNGQVVDQVGVTDFTADKTSAKADGT-----EAITYTATVKKNGVAQANV 594

Query: 339 DSPVTTLSGTA--SSTFQNTSCSG------NSERNDQIIASVVAGNQTLTAELDFS-LAS 389
+SGTA S+ NT+ SG S++ Q++ S T +
Sbjct: 595 PVSFNIVSGTAVLSANSANTNGSGKATVTLKSDKPGQVVVSAKTAEMTSALNANAVIFVD 654

Query: 390 QTLANLSFISAEPTSIRIKGAGGTNSSKSSLITFKV-ADANGQPIAQQDVDFSLDTSVGG 448
QT A+++ I A+ T+ ++ IT+ V +P++ Q+V F+
Sbjct: 655 QTKASITEIKADKTTA--------VANGQDAITYTVKVMKGDKPVSNQEVTFTTTLGKLS 706

Query: 449 IKFANGDTNTSNTSNSAGLVSTTVLSGTVPTPVRVLASATANGESVTTQSEQLTINTGLP 508
+ +N L STT V RV A LTI+ G
Sbjct: 707 NS---TEKTDTNGYAKVTLTSTTPGKSLV--SARVSDVAVDVKAPEVEFFTTLTIDDGNI 761

Query: 509 QQLGFSLSSSL 519
+ +G + L
Sbjct: 762 EIVGTGVKGKL 772


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3745RTXTOXIND416e-06 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 40.6 bits (95), Expect = 6e-06
Identities = 22/155 (14%), Positives = 45/155 (29%), Gaps = 27/155 (17%)

Query: 45 ISSKVPGRVEEVLVRRGDKVNEGDLL---------YAIYSPELKAKLMQAEGGRDAALAM 95
I V+E++V+ G+ V +GD+L + + E R L+
Sbjct: 99 IKPIENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSR 158

Query: 96 QQEADNGARKQQIAASKEQWLKAQAAAKLARTTFDRVEVLFNEGVLARQKRDEAFTQWQA 155
E + ++ E + + + ++ R E F+ WQ
Sbjct: 159 SIELNK---LPELKLPDEPYFQNVSEEEVLR---------------LTSLIKEQFSTWQN 200

Query: 156 AKYTEQAALAMYQMADEGARVETKAAAAGNARMAE 190
KY ++ L + +
Sbjct: 201 QKYQKELNLDKKRAERLTVLARINRYENLSRVEKS 235


91Spea_3754Spea_3771N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_37540131.463376rod shape-determining protein MreB
Spea_3755-1140.857683PA14 domain-containing protein
Spea_37560170.352063MSHA biogenesis protein MshP
Spea_3757015-0.000448methylation site containing protein
Spea_3758116-0.620099methylation site containing protein
Spea_3759-214-0.073696MSHA pilin protein MshC
Spea_37601120.595162methylation site containing protein
Spea_3761-1141.239469MSHA pilin protein MshA
Spea_37620161.772491methylation site containing protein
Spea_37630151.932033hypothetical protein
Spea_37640161.707231type II secretion system protein
Spea_37651161.123159type II secretion system protein E
Spea_37662180.336319hypothetical protein
Spea_3767015-0.383769MSHA biogenesis protein MshM
Spea_3768015-0.760823pilus (MSHA type) biogenesis protein MshL
Spea_3769-115-1.277772hypothetical protein
Spea_3770014-1.266387MSHA biogenesis protein MshJ
Spea_3771-113-1.047163fimbrial assembly family protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3754SHAPEPROTEIN5510.0 Bacterial cell shape determinant MreB/Mbl protein s...
		>SHAPEPROTEIN#Bacterial cell shape determinant MreB/Mbl protein

signature.
Length = 347

Score = 551 bits (1421), Expect = 0.0
Identities = 311/348 (89%), Positives = 330/348 (94%), Gaps = 1/348 (0%)

Query: 1 MFKKLRGIFSNDLSIDLGTANTLIYVREEGIVLNEPSVVAIRGERSGSGQKSVAAVGTEA 60
M KK RG+FSNDLSIDLGTANTLIYV+ +GIVLNEPSVVAIR +R KSVAAVG +A
Sbjct: 1 MLKKFRGMFSNDLSIDLGTANTLIYVKGQGIVLNEPSVVAIRQDR-AGSPKSVAAVGHDA 59

Query: 61 KQMLGRTPGNIQAIRPMKDGVIADFYVTEKMLQHFIKQVHNNSVFRPSPRVLVCVPVGAT 120
KQMLGRTPGNI AIRPMKDGVIADF+VTEKMLQHFIKQVH+NS RPSPRVLVCVPVGAT
Sbjct: 60 KQMLGRTPGNIAAIRPMKDGVIADFFVTEKMLQHFIKQVHSNSFMRPSPRVLVCVPVGAT 119

Query: 121 QVERRAIRESAMGAGAREVYLIEEPMAAAIGAGLPVSEATGSMVVDIGGGTTEVAIISLN 180
QVERRAIRESA GAGAREV+LIEEPMAAAIGAGLPVSEATGSMVVDIGGGTTEVA+ISLN
Sbjct: 120 QVERRAIRESAQGAGAREVFLIEEPMAAAIGAGLPVSEATGSMVVDIGGGTTEVAVISLN 179

Query: 181 GVVYSSSVRIGGDKFDDAIINYVRRNYGSLIGEATAERIKHTIGTAYPGDEVLEIEVRGR 240
GVVYSSSVRIGGD+FD+AIINYVRRNYGSLIGEATAERIKH IG+AYPGDEV EIEVRGR
Sbjct: 180 GVVYSSSVRIGGDRFDEAIINYVRRNYGSLIGEATAERIKHEIGSAYPGDEVREIEVRGR 239

Query: 241 NLAEGVPRSFTLNSNEILEALQEPLSGIVSAVMVALEQSPPELASDISERGMVLTGGGAL 300
NLAEGVPR FTLNSNEILEALQEPL+GIVSAVMVALEQ PPELASDISERGMVLTGGGAL
Sbjct: 240 NLAEGVPRGFTLNSNEILEALQEPLTGIVSAVMVALEQCPPELASDISERGMVLTGGGAL 299

Query: 301 IRDLDRLLMQETGIPVMIAEDPLTCVARGGGRALEMIDMHGGDLFSEE 348
+R+LDRLLM+ETGIPV++AEDPLTCVARGGG+ALEMIDMHGGDLFSEE
Sbjct: 300 LRNLDRLLMEETGIPVVVAEDPLTCVARGGGKALEMIDMHGGDLFSEE 347


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3755BINARYTOXINB340.007 Binary toxin B family signature.
		>BINARYTOXINB#Binary toxin B family signature.

Length = 764

Score = 33.5 bits (76), Expect = 0.007
Identities = 22/95 (23%), Positives = 43/95 (45%), Gaps = 14/95 (14%)

Query: 279 GYIEAPETGEYTFAIDGDDAIELLIDGEVIKGFYGVHSTCDCTRYQGKVSLEQG-AHTIE 337
G+I+ ++ EYTFA D+ + + +D + + K+ LE+G + I+
Sbjct: 96 GFIKVKKSDEYTFATSADNHVTMWVDDQ---------EVINKASNSNKIRLEKGRLYQIK 146

Query: 338 LRFHE---TFGAEAFRLYWQPPSANSLTIVPASQL 369
+++ T F+LYW S N ++ + L
Sbjct: 147 IQYQRENPTEKGLDFKLYWT-DSQNKKEVISSDNL 180


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3757BCTERIALGSPG343e-04 Bacterial general secretion pathway protein G signa...
		>BCTERIALGSPG#Bacterial general secretion pathway protein G

signature.
Length = 145

Score = 34.1 bits (78), Expect = 3e-04
Identities = 12/20 (60%), Positives = 18/20 (90%)

Query: 20 RGRGFTLVEMVTVIIILGVL 39
+ RGFTL+E++ VI+I+GVL
Sbjct: 6 KQRGFTLLEIMVVIVIIGVL 25


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3758BCTERIALGSPH300.004 Bacterial general secretion pathway protein H signa...
		>BCTERIALGSPH#Bacterial general secretion pathway protein H

signature.
Length = 170

Score = 29.9 bits (67), Expect = 0.004
Identities = 12/42 (28%), Positives = 28/42 (66%), Gaps = 3/42 (7%)

Query: 14 QKAFTLIELVVGMVVISIAFVLLSTMLFPQA--ERAADTLHR 53
Q+ FTL+E+++ ++++ ++ ++ + FP + + AA TL R
Sbjct: 3 QRGFTLLEMMLILLLMGVSAGMV-LLAFPASRDDSAAQTLAR 43


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3759BCTERIALGSPG442e-08 Bacterial general secretion pathway protein G signa...
		>BCTERIALGSPG#Bacterial general secretion pathway protein G

signature.
Length = 145

Score = 44.5 bits (105), Expect = 2e-08
Identities = 18/69 (26%), Positives = 36/69 (52%), Gaps = 8/69 (11%)

Query: 1 MHRARQHAGFTLVELVTTIILIAILAVVVIPRLLTSSSYSAFTLQDEFISELRKVQIMAM 60
M + GFTL+E++ I++I +LA +V+P L+ + +++ + I+A+
Sbjct: 1 MRATDKQRGFTLLEIMVVIVIIGVLASLVVPNLMGN--------KEKADKQKAVSDIVAL 52

Query: 61 NNQDRCYRL 69
N Y+L
Sbjct: 53 ENALDMYKL 61


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3760BCTERIALGSPG502e-10 Bacterial general secretion pathway protein G signa...
		>BCTERIALGSPG#Bacterial general secretion pathway protein G

signature.
Length = 145

Score = 50.3 bits (120), Expect = 2e-10
Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 4/54 (7%)

Query: 2 KMQKQSGFTLIELVVVIIILGILAVTAAPKFINLQSDARA----STLQGMKGAL 51
KQ GFTL+E++VVI+I+G+LA P + + A S + ++ AL
Sbjct: 3 ATDKQRGFTLLEIMVVIVIIGVLASLVVPNLMGNKEKADKQKAVSDIVALENAL 56


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3761BCTERIALGSPG472e-09 Bacterial general secretion pathway protein G signa...
		>BCTERIALGSPG#Bacterial general secretion pathway protein G

signature.
Length = 145

Score = 47.2 bits (112), Expect = 2e-09
Identities = 18/53 (33%), Positives = 30/53 (56%), Gaps = 4/53 (7%)

Query: 9 MQKQNGFTLIELVVVIIILGILAVTAAPKFINLQSDARA----SALQGVKGAI 57
KQ GFTL+E++VVI+I+G+LA P + + A S + ++ A+
Sbjct: 4 TDKQRGFTLLEIMVVIVIIGVLASLVVPNLMGNKEKADKQKAVSDIVALENAL 56


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3762BCTERIALGSPG431e-07 Bacterial general secretion pathway protein G signa...
		>BCTERIALGSPG#Bacterial general secretion pathway protein G

signature.
Length = 145

Score = 42.6 bits (100), Expect = 1e-07
Identities = 14/35 (40%), Positives = 27/35 (77%)

Query: 6 QKGFSLIELVIVIVILGLLAATAIPRFLNVTDDAE 40
Q+GF+L+E+++VIVI+G+LA+ +P + + A+
Sbjct: 7 QRGFTLLEIMVVIVIIGVLASLVVPNLMGNKEKAD 41


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3764BCTERIALGSPF298e-100 Bacterial general secretion pathway protein F signa...
		>BCTERIALGSPF#Bacterial general secretion pathway protein F

signature.
Length = 408

Score = 298 bits (764), Expect = e-100
Identities = 112/406 (27%), Positives = 204/406 (50%), Gaps = 4/406 (0%)

Query: 1 MPTYQYRGRSAQGEQVKGLVDAASESAAADQLMSRGVIPLEL----VLAKEVKEFNLKTL 56
M Y Y+ AQG++ +G +A S A L RG++PL + ++ L
Sbjct: 1 MAQYHYQALDAQGKKCRGTQEADSARQARQLLRERGLVPLSVDENRGDQQKSGSTGLSLR 60

Query: 57 FKGKVALEELQIFTRQMYSLTRSGIPILRAIAGLSETTHSVRMKEALDDISEQLTSGRPL 116
K +++ +L + TRQ+ +L + +P+ A+ +++ + + + + + ++ G L
Sbjct: 61 RKIRLSTSDLALLTRQLATLVAASMPLEEALDAVAKQSEKPHLSQLMAAVRSKVMEGHSL 120

Query: 117 SSAMNQHPDVFDALFVSMVHVGENTGKLEDAFIQLSGYIEREQETRRRIKAAMRYPIFVL 176
+ AM P F+ L+ +MV GE +G L+ +L+ Y E+ Q+ R RI+ AM YP +
Sbjct: 121 ADAMKCFPGSFERLYCAMVAAGETSGHLDAVLNRLADYTEQRQQMRSRIQQAMIYPCVLT 180

Query: 177 IAIAIAMVILNIMVIPKFAEMFSRFGADLPWATKLLINTSNVFVNYWPLMLLVLVAGFVG 236
+ + IL +V+PK E F LP +T++L+ S+ + P MLL L+AGF+
Sbjct: 181 VVAIAVVSILLSVVVPKVVEQFIHMKQALPLSTRVLMGMSDAVRTFGPWMLLALLAGFMA 240

Query: 237 IRYWHSTEKGEKQWDKWKLNIPAVGSIIERSTLSRYCRSFSMMLSAGVPMTQALSLVADA 296
R EK + + L++P +G I +RY R+ S++ ++ VP+ QA+ + D
Sbjct: 241 FRVMLRQEKRRVSFHRRLLHLPLIGRIARGLNTARYARTLSILNASAVPLLQAMRISGDV 300

Query: 297 VDNAYMHDSIVGMRRGIESGESMLRVSNNSQLFTPLVLQMVAVGEETGQIDQLLNDAADF 356
+ N Y + + G S+ + + LF P++ M+A GE +G++D +L AAD
Sbjct: 301 MSNDYARHRLSLATDAVREGVSLHKALEQTALFPPMMRHMIASGERSGELDSMLERAADN 360

Query: 357 YEGEVDYDLKNLTAKLEPLLIGFVACIVLVLALGIYLPMWDMLNVV 402
+ E + EPLL+ +A +VL + L I P+ + ++
Sbjct: 361 QDREFSSQMTLALGLFEPLLVVSMAAVVLFIVLAILQPILQLNTLM 406


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3766SYCDCHAPRONE352e-04 Gram-negative bacterial type III secretion SycD cha...
		>SYCDCHAPRONE#Gram-negative bacterial type III secretion SycD

chaperone signature.
Length = 168

Score = 35.3 bits (81), Expect = 2e-04
Identities = 18/96 (18%), Positives = 39/96 (40%)

Query: 332 SLAMIPDSSDLALKKWHQQSDLAQKQKDFPTAEQSFRQLAKHEPNQGRWWMGLAYALDAQ 391
++AM+ + S L++ + + + + A + F+ L + R+++GL A
Sbjct: 24 TIAMLNEISSDTLEQLYSLAFNQYQSGKYEDAHKVFQALCVLDHYDSRFFLGLGACRQAM 83

Query: 392 QKYTEAKSAYNQALSQGNLSVQAKVYVDNRLLQLGA 427
+Y A +Y+ + + LLQ G
Sbjct: 84 GQYDLAIHSYSYGAIMDIKEPRFPFHAAECLLQKGE 119


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3768BCTERIALGSPD1701e-47 Bacterial general secretion pathway protein D signa...
		>BCTERIALGSPD#Bacterial general secretion pathway protein D

signature.
Length = 660

Score = 170 bits (431), Expect = 1e-47
Identities = 78/347 (22%), Positives = 144/347 (41%), Gaps = 37/347 (10%)

Query: 211 NSNEQTNGTFIRSK--TKSDFWGELKETLVSIVGNTGGGRQ---------VVVTPQAGLV 259
Q N I K SD L ++ + + Q +
Sbjct: 262 QQATQGNTKVIYLKYAKASDLVEVLTGISSTMQSEKQAAKPVAALDKNIIIKAHGQTNAL 321

Query: 260 TIRAYPNEIRQVRSFIKTAESHLQRQVILEAKVLEVTLSDGYQQGIHW---ESVLGHAGS 316
+ A P+ + + I + + QV++EA + EV +DG GI W + + +
Sbjct: 322 IVTAAPDVMNDLERVIAQLDIR-RPQVLVEAIIAEVQDADGLNLGIQWANKNAGMTQFTN 380

Query: 317 TDISFGTSPAAGLG----DTITNALGGVTSI------KLEGSDFSTMISLLDTQGDVDVL 366
+ + T+ A T++++L S +++ +++ L + D+L
Sbjct: 381 SGLPISTAIAGANQYNKDGTVSSSLASALSSFNGIAAGFYQGNWAMLLTALSSSTKNDIL 440

Query: 367 SSPRVTASNNQKAVIKVGTDEYFVTDVSSTTVAGNTPVTTPEVELTPFFSGIALDVTPQI 426
++P + +N +A VG + +T S T +G+ T E + GI L V PQI
Sbjct: 441 ATPSIVTLDNMEATFNVGQEVPVLT--GSQTTSGDNIFNTVERKTV----GIKLKVKPQI 494

Query: 427 DEQGNVLLHIHPSVIDIKEQVKSIKIADSTLELPLAQSEIRESDTVIKAASGDVVVIGGL 486
+E +VLL I V + + + ++ +L + R + + SG+ VV+GGL
Sbjct: 495 NEGDSVLLEIEQEVSSVADAA-----SSTSSDLGATFN-TRTVNNAVLVGSGETVVVGGL 548

Query: 487 MKSENIELVSKVPLLGDIPFLGEAFTNRANSTVKTELVILLKPIVVG 533
+ + KVPLLGDIP +G F + + K L++ ++P V+
Sbjct: 549 LDKSVSDTADKVPLLGDIPVIGALFRSTSKKVSKRNLMLFIRPTVIR 595


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3771SECFTRNLCASE300.005 Bacterial translocase SecF protein signature.
		>SECFTRNLCASE#Bacterial translocase SecF protein signature.

Length = 333

Score = 30.2 bits (68), Expect = 0.005
Identities = 19/81 (23%), Positives = 33/81 (40%), Gaps = 3/81 (3%)

Query: 11 TLFPPELRLSFLRLNQATLVIVVGLLCASA---LVFGLNTSLESDKAQLVQTKQALDAEK 67
L P + F R AT + ++ AS LV GLN ++ ++T+ +
Sbjct: 6 KLVPEKTNFDFFRWQWATFGAAIVMMIASVILPLVIGLNFGIDFKGGTTIRTESTTAIDV 65

Query: 68 KDLEAALAKRGPSEALVAEVN 88
AAL + +++EV
Sbjct: 66 GVYRAALEPLELGDVIISEVR 86


92Spea_3796Spea_3808N        Y        YPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_3796014-1.809301twin-arginine translocation protein subunit
Spea_3797015-1.485042Sec-independent protein translocase subunit
Spea_3798115-1.408621hypothetical protein
Spea_3799015-1.349298TatD-like deoxyribonuclease
Spea_3800017-1.563932diguanylate cyclase
Spea_3801123-0.433556delta-aminolevulinic acid dehydratase
Spea_38032210.039548**preprotein translocase subunit SecA
Spea_38040150.502021peptidase M23B
Spea_38051151.320174hypothetical protein
Spea_38061131.791894UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine
Spea_38070142.290545cell division protein FtsZ
Spea_38080152.537789cell division protein FtsA
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3796TATBPROTEIN1063e-32 Bacterial sec-independent translocation TatB protein...
		>TATBPROTEIN#Bacterial sec-independent translocation TatB protein

signature.
Length = 171

Score = 106 bits (265), Expect = 3e-32
Identities = 56/118 (47%), Positives = 82/118 (69%), Gaps = 2/118 (1%)

Query: 1 MFDGIGFMELLLIGILGLVVLGPERLPTAVRSISSWIRAMKKMANSVKDELEQELKIEQL 60
MFD IGF ELLL+ I+GLVVLGP+RLP AV++++ WIRA++ +A +V++EL QELK+++
Sbjct: 1 MFD-IGFSELLLVFIIGLVVLGPQRLPVAVKTVAGWIRALRSLATTVQNELTQELKLQEF 59

Query: 61 HSDLKNAESQGLKNLSPELQDSIDQLKEAAQSVNRPYQVEDV-PAAKETPAKETPTAE 117
LK E L NL+PEL+ S+D+L++AA+S+ R Y D A+ E P +
Sbjct: 60 QDSLKKVEKASLTNLTPELKASMDELRQAAESMKRSYVANDPEKASDEAHTIHNPVVK 117


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3800GPOSANCHOR310.015 Gram-positive coccus surface protein anchor signature.
		>GPOSANCHOR#Gram-positive coccus surface protein anchor signature.

Length = 539

Score = 31.2 bits (70), Expect = 0.015
Identities = 14/84 (16%), Positives = 30/84 (35%), Gaps = 2/84 (2%)

Query: 382 AIRYNDERLNKLKIQKDALIQANKAQETKEEALRIEARSSEKLSQMVQERTLELEIALRE 441
A+ + L A E ++ L +++ Q ++ A ++
Sbjct: 268 ALEGAMNFSTADSAKIKTLEAEKAALEAEKADLEHQSQVLNANRQSLRRDLDASREAKKQ 327

Query: 442 LNEANQKLTEQTRVD--SLTGVKN 463
L +QKL EQ ++ S ++
Sbjct: 328 LEAEHQKLEEQNKISEASRQSLRR 351


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3803SECA13240.0 SecA protein signature.
		>SECA#SecA protein signature.

Length = 901

Score = 1324 bits (3427), Expect = 0.0
Identities = 648/906 (71%), Positives = 756/906 (83%), Gaps = 6/906 (0%)

Query: 1 MFGKLLTKVFGSRNDRTLKAFGKVVNKVNALEAEYEKLSDEELKAKTAHFRERLDGGESL 60
M KLLTKVFGSRNDRTL+ KVVN +NA+E E EKLSDEELK KTA FR RL+ GE L
Sbjct: 1 MLIKLLTKVFGSRNDRTLRRMRKVVNIINAMEPEMEKLSDEELKGKTAEFRARLEKGEVL 60

Query: 61 EGVLPEAFATVREASKRVFDMRHFDVQLIGGMILDSNRIAEMRTGEGKTLTATLPAYLNG 120
E ++PEAFA VREASKRVF MRHFDVQL+GGM+L+ IAEMRTGEGKTLTATLPAYLN
Sbjct: 61 ENLIPEAFAVVREASKRVFGMRHFDVQLLGGMVLNERCIAEMRTGEGKTLTATLPAYLNA 120

Query: 121 LTGKGVHVITVNDYLAGRDAENNRPLFEFLGLTVGINVAGLGQVEKKAAYDADITYGTNN 180
LTGKGVHV+TVNDYLA RDAENNRPLFEFLGLTVGIN+ G+ K+ AY ADITYGTNN
Sbjct: 121 LTGKGVHVVTVNDYLAQRDAENNRPLFEFLGLTVGINLPGMPAPAKREAYAADITYGTNN 180

Query: 181 EFGFDYLRDNMAFSPSERVQRPLHYALIDEVDSILIDEARTPLIISGAAEDSSELYIKIN 240
E+GFDYLRDNMAFSP ERVQR LHYAL+DEVDSILIDEARTPLIISG AEDSSE+Y ++N
Sbjct: 181 EYGFDYLRDNMAFSPEERVQRKLHYALVDEVDSILIDEARTPLIISGPAEDSSEMYKRVN 240

Query: 241 TLIPNLIAQEKEDTEDYVGEGDYSVDEKSKQVHMTERGQEKVEVLLTERGMLAEGDSLYS 300
+IP+LI QEKED+E + GEG +SVDEKS+QV++TERG +E LL + G++ EG+SLYS
Sbjct: 241 KIIPHLIRQEKEDSETFQGEGHFSVDEKSRQVNLTERGLVLIEELLVKEGIMDEGESLYS 300

Query: 301 AANISLLHHVNAALRAHTLFEKDVDYIVQDNEVVIVDEHTGRTMPGRRWSEGLHQAVEAK 360
ANI L+HHV AALRAH LF +DVDYIV+D EV+IVDEHTGRTM GRRWS+GLHQAVEAK
Sbjct: 301 PANIMLMHHVTAALRAHALFTRDVDYIVKDGEVIIVDEHTGRTMQGRRWSDGLHQAVEAK 360

Query: 361 EGVHIQNENQTLASITFQNFFRQYEKLAGMTGTADTEAFEFQHIYGLDTVVVPTNRPMVR 420
EGV IQNENQTLASITFQN+FR YEKLAGMTGTADTEAFEF IY LDTVVVPTNRPM+R
Sbjct: 361 EGVQIQNENQTLASITFQNYFRLYEKLAGMTGTADTEAFEFSSIYKLDTVVVPTNRPMIR 420

Query: 421 KDHPDLVYLTAEEKYAAIVKDIVGCRERGQPVLVGTVSIEQSELLHSLLKKEKIPHEILN 480
KD PDLVY+T EK AI++DI +GQPVLVGT+SIE+SEL+ + L K I H +LN
Sbjct: 421 KDLPDLVYMTEAEKIQAIIEDIKERTAKGQPVLVGTISIEKSELVSNELTKAGIKHNVLN 480

Query: 481 AKFHEREADIVAQAGRTGAVTVATNMAGRGTDIVLGGNWNMEIEALTNPTDEQKAKIKAD 540
AKFH EA IVAQAG AVT+ATNMAGRGTDIVLGG+W E+ AL NPT EQ KIKAD
Sbjct: 481 AKFHANEAAIVAQAGYPAAVTIATNMAGRGTDIVLGGSWQAEVAALENPTAEQIEKIKAD 540

Query: 541 WKIRHDEVVEAGGLHILGTERHESRRIDNQLRGRSGRQGDSGSSRFYLSMEDSLMRIFAS 600
W++RHD V+EAGGLHI+GTERHESRRIDNQLRGRSGRQGD+GSSRFYLSMED+LMRIFAS
Sbjct: 541 WQVRHDAVLEAGGLHIIGTERHESRRIDNQLRGRSGRQGDAGSSRFYLSMEDALMRIFAS 600

Query: 601 DRVSSMMKKLGMEEGEAIEHPWVSRAIENAQRKVEARNFDIRKQLLEFDDVANDQRQVVY 660
DRVS MM+KLGM+ GEAIEHPWV++AI NAQRKVE+RNFDIRKQLLE+DDVANDQR+ +Y
Sbjct: 601 DRVSGMMRKLGMKPGEAIEHPWVTKAIANAQRKVESRNFDIRKQLLEYDDVANDQRRAIY 660

Query: 661 AQRNELMDAESIQDTITNIQEDVVNGLVDQYIPRQSVEELWDVEGLEKRLQQEYAMSLPI 720
+QRNEL+D + +TI +I+EDV +D YIP QS+EE+WD+ GL++RL+ ++ + LPI
Sbjct: 661 SQRNELLDVSDVSETINSIREDVFKATIDAYIPPQSLEEMWDIPGLQERLKNDFDLDLPI 720

Query: 721 QEWLDKEDDLHEETLRERIVETWVNAYKAKEEMVGEQVLRQFEKAVMLQTLDGLWKEHLS 780
EWLDKE +LHEETLRERI+ + Y+ KEE+VG +++R FEK VMLQTLD LWKEHL+
Sbjct: 721 AEWLDKEPELHEETLRERILAQSIEVYQRKEEVVGAEMMRHFEKGVMLQTLDSLWKEHLA 780

Query: 781 AMDHLRQGIHLRGYAQKNPKQEYKRESFELFQQMLESLKHDVISVLSKVQVQAQSDVEEM 840
AMD+LRQGIHLRGYAQK+PKQEYKRESF +F MLESLK++VIS LSKVQV+ +VEE+
Sbjct: 781 AMDYLRQGIHLRGYAQKDPKQEYKRESFSMFAAMLESLKYEVISTLSKVQVRMPEEVEEL 840

Query: 841 EERRRQEDAKIRRDYQHAEAEAIVGAEESAALAATQPTVRDGEKVGRNDPCPCGSGKKYK 900
E++RR E ++ A+ + + ++ +A AA KVGRNDPCPCGSGKKYK
Sbjct: 841 EQQRRMEAERL------AQMQQLSHQDDDSAAAAALAAQTGERKVGRNDPCPCGSGKKYK 894

Query: 901 QCHGKL 906
QCHG+L
Sbjct: 895 QCHGRL 900


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3804PF06580330.002 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 32.5 bits (74), Expect = 0.002
Identities = 15/65 (23%), Positives = 28/65 (43%)

Query: 6 FIQGRNGATRWQPGKRWLLLPILLIAAGTGLYQHNAKQLTQQQANVDSERMAREEQKDEL 65
FI + A + +++ + LY +QA +D +MA Q+ +L
Sbjct: 104 FINTKPVAFTLPLALSIIFNVVVVTFMWSLLYFGWHFFKNYKQAEIDQWKMASMAQEAQL 163

Query: 66 IALKS 70
+ALK+
Sbjct: 164 MALKA 168


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3808SHAPEPROTEIN611e-12 Bacterial cell shape determinant MreB/Mbl protein s...
		>SHAPEPROTEIN#Bacterial cell shape determinant MreB/Mbl protein

signature.
Length = 347

Score = 61.3 bits (149), Expect = 1e-12
Identities = 49/222 (22%), Positives = 90/222 (40%), Gaps = 20/222 (9%)

Query: 150 SGMRMEAKVHIVTC----ANDMAKNITK-SVERCGLKVDDLVFSAIASADSVLTDDEKDL 204
S M ++ C A + + + S + G + L+ +A+A +
Sbjct: 100 SNSFMRPSPRVLVCVPVGATQVERRAIRESAQGAGAREVFLIEEPMAAAIGAGLPVSEAT 159

Query: 205 GVCLVDIGGGTTDIAVYTNGALRHCAVVPVAGNQVTNDIAKIFR------TPLSHAEQIK 258
G +VDIGGGTT++AV + + + + V + G++ I R + AE+IK
Sbjct: 160 GSMVVDIGGGTTEVAVISLNGVVYSSSVRIGGDRFDEAIINYVRRNYGSLIGEATAERIK 219

Query: 259 VQHASARSAMVSREDSIEVPS---VGGRPSR-SMSRHTLAEVVEPRYQELFELILKQLRD 314
+ SA IEV G P +++ + + E ++ + ++ L
Sbjct: 220 HEIGSAYPG--DEVREIEVRGRNLAEGVPRGFTLNSNEILEALQEPLTGIVSAVMVALEQ 277

Query: 315 SGLE---DQVAAGIVITGGTASIEGAVDIAEATFGMPVRMAQ 353
E D G+V+TGG A + + G+PV +A+
Sbjct: 278 CPPELASDISERGMVLTGGGALLRNLDRLLMEETGIPVVVAE 319


93Spea_3866Spea_3872N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_38661152.860671TetR family transcriptional regulator
Spea_38672143.114797OPT family oligopeptide transporter
Spea_38682162.911209OmpA/MotB domain-containing protein
Spea_38692162.963071outer membrane adhesin-like protein
Spea_38700192.106781hypothetical protein
Spea_38710182.469419pyridoxal-dependent decarboxylase
Spea_38720192.211330amidohydrolase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3866HTHTETR671e-15 TetR bacterial regulatory protein HTH signature.
		>HTHTETR#TetR bacterial regulatory protein HTH signature.

Length = 215

Score = 66.6 bits (162), Expect = 1e-15
Identities = 25/137 (18%), Positives = 56/137 (40%), Gaps = 7/137 (5%)

Query: 3 RRDREVKLLDIARELILEYGMVSFKFTDIAKRAEVSRATLYKYFSGKEDVLVSLFVHDAE 62
++ +LD+A L + G+ S +IAK A V+R +Y +F K D+ ++
Sbjct: 9 AQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSES 68

Query: 63 NTKQMLVDIQADLTLNNREKILLSLLAPVASSMETLNRSGTLLLSANPGIFMYASDKQQA 122
N ++ ++ QA + + L+ + S++ R + ++ +
Sbjct: 69 NIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLM-------EIIFHKCEFVG 121

Query: 123 RLEQIVSEIRQITLEFW 139
+ + R + LE +
Sbjct: 122 EMAVVQQAQRNLCLESY 138


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3868OMPADOMAIN1221e-33 OMPA domain signature.
		>OMPADOMAIN#OMPA domain signature.

Length = 346

Score = 122 bits (307), Expect = 1e-33
Identities = 88/401 (21%), Positives = 136/401 (33%), Gaps = 111/401 (27%)

Query: 22 VVQAAENESQQTEHMWSQGWYLGGQFGLATTNVSNAGLDELYEQAGIDASSTKVDDSGAS 81
V QAA ++ WY G + G + Y G ++ ++
Sbjct: 18 VAQAAPKDNT---------WYTGAKLGWSQ-----------YHDTGFINNNGPTHENQLG 57

Query: 82 YGLFLGYKFNQYFSVEAGYLDLGERSVEFSGQTTDLDAYYDLAEHVYPETGDGWSLSVLG 141
G F GY+ N Y E GY LG + S + A G L+
Sbjct: 58 AGAFGGYQVNPYVGFEMGYDWLGRMPYKGSVENGAYKAQ-------------GVQLTAKL 104

Query: 142 TYPLSERFSVTGKLGYFAWELDAVTSSIADEASQVGSDSHSGSGVWLGAELGYQINHDMQ 201
YP+++ + +LG W D +++ G + +G + Y I ++
Sbjct: 105 GYPITDDLDIYTRLGGMVWRADT-------KSNVYGKNHDTGVSPVFAGGVEYAITPEIA 157

Query: 202 AYVSYQHMPLDADE--------VGVFALGLRYWFGSDSRDAAPVLPAAVVPTLAKIGSDG 253
+ YQ D G+ +LG+ Y FG +AAPV+ A P
Sbjct: 158 TRLEYQWTNNIGDAHTIGTRPDNGMLSLGVSYRFGQG--EAAPVVAPAPAP--------- 206

Query: 254 DSDSDGVFNAQDQCLDTPSTHAVDSRGCTLFAPRVVEMKLT----VLYENDSDKIDLSNT 309
AP V T VL+ + +
Sbjct: 207 -------------------------------APEVQTKHFTLKSDVLFNFNKATLKPEGQ 235

Query: 310 DKIQKLADFIEQYDIK--QITVFGHTSAVGSQAYNQKLSERRAASVAEMLAADFNIATGI 367
+ +L + D K + V G+T +GS AYNQ LSERRA SV + L + I
Sbjct: 236 AALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDAYNQGLSERRAQSVVDYLISK-GIPADK 294

Query: 368 IKAVGKGESEPIS--------------HIPEQNRRIEVYLN 394
I A G GES P++ +RR+E+ +
Sbjct: 295 ISARGMGESNPVTGNTCDNVKQRAALIDCLAPDRRVEIEVK 335


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3869CHLAMIDIAOM6320.044 Chlamydia cysteine-rich outer membrane protein 6 si...
		>CHLAMIDIAOM6#Chlamydia cysteine-rich outer membrane protein 6

signature.
Length = 547

Score = 32.4 bits (73), Expect = 0.044
Identities = 39/155 (25%), Positives = 59/155 (38%), Gaps = 31/155 (20%)

Query: 936 VEVTIELSNTGTAPAYDVVLTDVLNANLFDVTSALEATTPANFSYSFVSPTVTYTTSSAI 995
VE I +SN G DVV+ D L+ + + LEA +S T +
Sbjct: 333 VEYVISVSNPGDLVLRDVVVEDTLSPGV----TVLEAAGAQ------ISCNKVVWTVKEL 382

Query: 996 APGQSLTFSYTANVKQGVVTGSSYDNNVSVVGDSQQGDISNPDRDSNDSATPTAAIGSLA 1055
PG+SL + + T + NNV V S G ++ A T +A
Sbjct: 383 NPGESLQYKVLVRAQ----TPGQFTNNVVVKSCSDCGTCTS-------CAEATTYWKGVA 431

Query: 1056 ISELVLIDSTESWTSDAVDGVEAAIGETLTYRLTV 1090
+ + ++D T D V +GE YR+ V
Sbjct: 432 ATHMCVVD-----TCDPV-----CVGENTVYRICV 456


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3872UREASE330.002 Urea amidohydrolase (urease) protein signature.
		>UREASE#Urea amidohydrolase (urease) protein signature.

Length = 570

Score = 33.2 bits (76), Expect = 0.002
Identities = 51/243 (20%), Positives = 79/243 (32%), Gaps = 70/243 (28%)

Query: 1 MNKLIINANVFNGTDNALIENVSILIEDNLIVKIG-----------EIDQSVADQVIDAK 49
++ +I NA + + I I ++D I IG I +VI +
Sbjct: 68 VDTVITNALILDHWG---IVKADIGLKDGRIAAIGKAGNPDMQPGVTIIVGPGTEVIAGE 124

Query: 50 GGTVMPGLIDAHVHITLSAPFNVIDTMTREEVAIRSARISEEMLMRGFTTVRDVAGNTLG 109
G V G +D+H+H + EE LM G T + + G T
Sbjct: 125 GKIVTAGGMDSHIHFI-------------------CPQQIEEALMSGLTCM--LGGGT-- 161

Query: 110 LKKSIDNGYAKGPRILPSMAAVSQTSGHSDYRQNQAQERIGQHEDSPMMKLGAMKVADGR 169
G A G A + T G R+ + D+ M L G
Sbjct: 162 -------GPAHGTL------ATTCTPGPWHI------ARMIEAADAFPMNLAFA--GKGN 200

Query: 170 AEVLKAVREQLFMGASQIKIMAGGGASSTFDPLDTLQFTLDEMKAAVEVATDYGTYVAAH 229
A + A+ E + GA+ +K+ G T + + VA +Y V H
Sbjct: 201 ASLPGALVEMVLGGATSLKLHEDWGT------------TPAAIDCCLSVADEYDVQVMIH 248

Query: 230 IHT 232
T
Sbjct: 249 TDT 251


94Spea_3929Spea_3941N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_39290203.695452signal transduction histidine kinase, nitrogen
Spea_39301204.119213nitrogen metabolism transcriptional regulator
Spea_39311192.970556cation diffusion facilitator family transporter
Spea_39320141.532513hypothetical protein
Spea_39330151.396851two component transcriptional regulator
Spea_3934-1151.407838histidine kinase
Spea_39350141.250944regulatory protein TetR
Spea_39361151.413035LysR family transcriptional regulator
Spea_39370172.247074hypothetical protein
Spea_3938-1173.147323tetraheme cytochrome c
Spea_3939-1183.424301flavocytochrome c
Spea_3940-2213.784861LysR family transcriptional regulator
Spea_3941-2223.850275quinone oxidoreductase
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3929PF06580452e-07 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 44.9 bits (106), Expect = 2e-07
Identities = 37/196 (18%), Positives = 70/196 (35%), Gaps = 39/196 (19%)

Query: 161 LNEFTDLIIEQADRLRNLVDRL-------LGPQKPTQHSLYNIHEVIQKVLKLVNVTLPD 213
LN LI+E + R ++ L L Q SL + V+ L+L ++ D
Sbjct: 179 LNNIRALILEDPTKAREMLTSLSELMRYSLRYSNARQVSLADELTVVDSYLQLASIQFED 238

Query: 214 NIELTQDYDPSIPDIEMDPDQLQQTILNIVQNAVQ-ALEPS--GGHIRLKTRTQHQVTIG 270
++ +P+I D+++ P +Q +V+N ++ + GG I LK +
Sbjct: 239 RLQFENQINPAIMDVQVPPMLVQT----LVENGIKHGIAQLPQGGKILLKGTKDNGT--- 291

Query: 271 TKRHKLVLMLSVIDDGPGIQPELMDTLFYPMVTGREQGSGLGLSIAHNFARLHGG---RI 327
+ L V + G ++ +G GL ++ G +I
Sbjct: 292 -------VTLEVENTGSLALKN------------TKESTGTGLQNVRERLQMLYGTEAQI 332

Query: 328 DCDSTVGHTEFTITLP 343
G + +P
Sbjct: 333 KLSEKQGKVNAMVLIP 348


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3930HTHFIS5690.0 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 569 bits (1467), Expect = 0.0
Identities = 205/474 (43%), Positives = 296/474 (62%), Gaps = 12/474 (2%)

Query: 5 VWILDDDSSIRWVLEKALQSAKFSSASFAAAESLWQALETAQPQVIVSDIRMPGTDGLTL 64
+ + DDD++IR VL +AL A + + A +LW+ + ++V+D+ MP + L
Sbjct: 6 ILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFDL 65

Query: 65 LERLQNHYPHIPVIIMTAHSDLDSAVSAYQAGAFEYLPKPFDIDEAISLVDRALTHAKEQ 124
L R++ P +PV++M+A + +A+ A + GA++YLPKPFD+ E I ++ RAL K +
Sbjct: 66 LPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKRR 125

Query: 125 SSTITTEEPIVATPEIIGEAPAMQEVFRAIGRLSRSSISVLINGQSGTGKELVASALHKH 184
S E+ ++G + AMQE++R + RL ++ ++++I G+SGTGKELVA ALH +
Sbjct: 126 PSK--LEDDSQDGMPLVGRSAAMQEIYRVLARLMQTDLTLMITGESGTGKELVARALHDY 183

Query: 185 SPRKGKPFIAINMAAIPKDLIESELFGHEKGAFTGAGSVRQGRFEQANGGTLFLDEIGDM 244
R+ PF+AINMAAIP+DLIESELFGHEKGAFTGA + GRFEQA GGTLFLDEIGDM
Sbjct: 184 GKRRNGPFVAINMAAIPRDLIESELFGHEKGAFTGAQTRSTGRFEQAEGGTLFLDEIGDM 243

Query: 245 PLDVQTRLLRVLADGQFYRVGGHSPVQVDVRIIAATHQNLEQRVHQGGFREDLFHRLNVI 304
P+D QTRLLRVL G++ VGG +P++ DVRI+AAT+++L+Q ++QG FREDL++RLNV+
Sbjct: 244 PMDAQTRLLRVLQQGEYTTVGGRTPIRSDVRIVAATNKDLKQSINQGLFREDLYYRLNVV 303

Query: 305 RVHLPPLSQRREDIPQLARHFLVIAAKEIGVEPKVLTKETANKLSQLPWPGNVRQLENTC 364
+ LPPL R EDIP L RHF+ A KE G++ K +E + PWPGNVR+LEN
Sbjct: 304 PLRLPPLRDRAEDIPDLVRHFVQQAEKE-GLDVKRFDQEALELMKAHPWPGNVRELENLV 362

Query: 365 RWLTVMASGQEILPLDLPPELLQEPKLSHAQSSDCDDWQGALKLFIDQRLSD-------- 416
R LT + I + EL E S + + ++ +++ +
Sbjct: 363 RRLTALYPQDVITREIIENELRSEIPDSPIEKAAARSGSLSISQAVEENMRQYFASFGDA 422

Query: 417 -GDSDLLTEVQPAFERILLETALKHTNGHKQEAAKRLGWGRNTLTRKLKELEMD 469
S L V E L+ AL T G++ +AA LG RNTL +K++EL +
Sbjct: 423 LPPSGLYDRVLAEMEYPLILAALTATRGNQIKAADLLGLNRNTLRKKIRELGVS 476


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3933HTHFIS986e-26 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 98.4 bits (245), Expect = 6e-26
Identities = 36/136 (26%), Positives = 66/136 (48%), Gaps = 1/136 (0%)

Query: 2 SRILLVDDDLGLSELLAQLLELEGFKLTLAHDGQSGLDLAIEQQFDLILLDVMLPKLNGF 61
+ IL+ DDD + +L Q L G+ + + + + DL++ DV++P N F
Sbjct: 4 ATILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAF 63

Query: 62 EVLRALRS-KKQTPVLMLTARGDEIDRVVGLEIGADDYLPKPFNDRELVARIRAIIRRTH 120
++L ++ + PVL+++A+ + + E GA DYLPKPF+ EL+ I +
Sbjct: 64 DLLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPK 123

Query: 121 IQPSEAPQAIHQYGDI 136
+PS+ +
Sbjct: 124 RRPSKLEDDSQDGMPL 139


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3934PF06580372e-04 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 36.8 bits (85), Expect = 2e-04
Identities = 27/124 (21%), Positives = 48/124 (38%), Gaps = 14/124 (11%)

Query: 282 EADQLEQMIAELLELSRVKLNANENKRSLELAETLSQVLDDADFEAQQ----QQKQLHID 337
+ + +M+ L EL R L N R + LA+ L+ V D+ + + Q
Sbjct: 189 DPTKAREMLTSLSELMRYSL-RYSNARQVSLADELTVV--DSYLQLASIQFEDRLQFENQ 245

Query: 338 IDESI----VIPLYPRPLSRAVENLLRNAIRYANTQVSIQAMASASASGVQIEIIDDGPG 393
I+ +I V P+ + L VEN +++ I I + V +E+ + G
Sbjct: 246 INPAIMDVQVPPMLVQTL---VENGIKHGIAQLPQGGKILLKGTKDNGTVTLEVENTGSL 302

Query: 394 ISDE 397

Sbjct: 303 ALKN 306


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3935HTHTETR387e-06 TetR bacterial regulatory protein HTH signature.
		>HTHTETR#TetR bacterial regulatory protein HTH signature.

Length = 215

Score = 38.5 bits (89), Expect = 7e-06
Identities = 26/170 (15%), Positives = 52/170 (30%), Gaps = 9/170 (5%)

Query: 3 NWQQRESYLTDIAERCLRGHKSFDLRRSHLVEASQISKGTIYNHFPTEADLVVAVATAHY 62
Q+ ++ D+A R + +A+ +++G IY HF ++DL +
Sbjct: 8 EAQETRQHILDVALRLFSQQGVSSTSLGEIAKAAGVTRGAIYWHFKDKSDLFSEIWELSE 67

Query: 63 RKRLERAA-IDDALYADYLTRFL-----MHHCWGLRDDLLYDRFIISRVMPNSELLQQVT 116
E D L+ + + II + V
Sbjct: 68 SNIGELELEYQAKFPGDPLSVLREILIHVLESTVTEERRRLLMEIIFHKCEFVGEMAVVQ 127

Query: 117 DENRAAFEQIYGEYIRWNRELIKAVGVVEGFN---RAELVGNYLRGALIN 163
R + Y + + I+A + A ++ Y+ G + N
Sbjct: 128 QAQRNLCLESYDRIEQTLKHCIEAKMLPADLMTRRAAIIMRGYISGLMEN 177


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3939HTHFIS310.010 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 31.3 bits (71), Expect = 0.010
Identities = 11/31 (35%), Positives = 17/31 (54%), Gaps = 1/31 (3%)

Query: 39 KWDKEVEVLIIGSGFAGLAAAIEATRKGAKD 69
K ++ VL++ S AI+A+ KGA D
Sbjct: 71 KARPDLPVLVM-SAQNTFMTAIKASEKGAYD 100


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3941NUCEPIMERASE290.017 Nucleotide sugar epimerase signature.
		>NUCEPIMERASE#Nucleotide sugar epimerase signature.

Length = 334

Score = 29.4 bits (66), Expect = 0.017
Identities = 11/27 (40%), Positives = 16/27 (59%)

Query: 151 VLVTGASGGVGSVAVTLLAQLGYRVVA 177
LVTGA+G +G L + G++VV
Sbjct: 3 YLVTGAAGFIGFHVSKRLLEAGHQVVG 29


95Spea_3988Spea_3994N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_39880233.836377RND family efflux transporter MFP subunit
Spea_39891223.084413CzcA family heavy metal efflux protein
Spea_39901211.763111glyoxalase/bleomycin resistance
Spea_3991-1181.185868diguanylate cyclase
Spea_3992-1171.581963secretion protein HlyD family protein
Spea_3993-2131.249005major facilitator superfamily permease
Spea_3994-2101.299113AraC family transcriptional regulator
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3988RTXTOXIND425e-06 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 42.1 bits (99), Expect = 5e-06
Identities = 31/167 (18%), Positives = 54/167 (32%), Gaps = 28/167 (16%)

Query: 400 LRKARLRLELLGVSSDTIKQLERTGKTIYRVPFYAEQDGFISKLTVR-HGMYVQPGDTLF 458
LR+ + LL +L + + A + +L V G V +TL
Sbjct: 304 LRQTTDNIGLL------TLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGVVTTAETLM 357

Query: 459 EIV-DLSSVWVIADVFENEQSWLEQGRPVEVTSAAQGLFD------LESTIDYIYPELDP 511
IV + ++ V A V + ++ G+ + A F L + I +
Sbjct: 358 VIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEA---FPYTRYGYLVGKVKNINLDAIE 414

Query: 512 VSR---AMRVRIKLDNPDKL-------LKPGTLVDVKLFGGPKREVL 548
R V I ++ L G V ++ G R V+
Sbjct: 415 DQRLGLVFNVIISIEENCLSTGNKNIPLSSGMAVTAEIKTG-MRSVI 460



Score = 33.3 bits (76), Expect = 0.003
Identities = 19/83 (22%), Positives = 37/83 (44%), Gaps = 10/83 (12%)

Query: 345 VNGWIETLMVHNVGQRVKKGQLLYELYSP----ELINAQDDYMQAVDYLTQDKSRGQGLL 400
N ++ ++V G+ V+KG +L +L + + + Q +QA +++R Q L
Sbjct: 103 ENSIVKEIIVKE-GESVRKGDVLLKLTALGAEADTLKTQSSLLQA----RLEQTRYQILS 157

Query: 401 RKARL-RLELLGVSSDTIKQLER 422
R L +L L + + Q
Sbjct: 158 RSIELNKLPELKLPDEPYFQNVS 180


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3989ACRIFLAVINRP6820.0 Acriflavin resistance protein family signature.
		>ACRIFLAVINRP#Acriflavin resistance protein family signature.

Length = 1034

Score = 682 bits (1761), Expect = 0.0
Identities = 217/1056 (20%), Positives = 425/1056 (40%), Gaps = 53/1056 (5%)

Query: 9 SIKQRAMVLVLTAVIALIGYQAMRMTPLDALPDLSDVQVIVKTSYPGQAPQLVEDQITYP 68
I++ VL ++ + G A+ P+ P ++ V V +YPG Q V+D +T
Sbjct: 5 FIRRPIFAWVLAIILMMAGALAILQLPVAQYPTIAPPAVSVSANYPGADAQTVQDTVTQV 64

Query: 69 LSTAMLAVPGAQTVRGFSM-FGDSYVYIIFEDGTDIYWARSRVLEYLSQTQGQLPDSV-T 126
+ M + + S G + + F+ GTD A+ +V L LP V
Sbjct: 65 IEQNMNGIDNLMYMSSTSDSAGSVTITLTFQSGTDPDIAQVQVQNKLQLATPLLPQEVQQ 124

Query: 127 PTLGPDASGVGWVFQYALVDRKGKHDLAQLRSLQDWFLKLELQSVEGVSEVATIGGMEQS 186
+ + S ++ V + +K L + GV +V G + +
Sbjct: 125 QGISVEKSSSSYLMVAGFVSDNPGTTQDDISDYVASNVKDTLSRLNGVGDVQLFGA-QYA 183

Query: 187 YQIIVDPHKLALYQIDLMTVKNALDNSNSSTGGSVIEMA------EAEYMITSSGYRQTL 240
+I +D L Y++ + V N L N + + I + +
Sbjct: 184 MRIWLDADLLNKYKLTPVDVINQLKVQNDQIAAGQLGGTPALPGQQLNASIIAQTRFKNP 243

Query: 241 ADFEEIPLGIVSESGTPVLMKDVAQLRTGPAARRGIAELNGEGEVVGGIVVMRYGENALA 300
+F ++ L V+ G+ V +KDVA++ G IA +NG+ G + + G NAL
Sbjct: 244 EEFGKVTL-RVNSDGSVVRLKDVARVELGGENYNVIARINGK-PAAGLGIKLATGANALD 301

Query: 301 TINNVKQKLKEIENGLPDGVELVITYDRSELILNSVDNLKHKVLEEMLVVAVICLIFLLH 360
T +K KL E++ P G++++ YD + + S+ + + E +++V ++ +FL +
Sbjct: 302 TAKAIKAKLAELQPFFPQGMKVLYPYDTTPFVQLSIHEVVKTLFEAIMLVFLVMYLFLQN 361

Query: 361 ARSTLVAIISLPISILISFIVMNMIGVNANIMSLGGIAIAIGAVVDAAIVMVENTHKHLE 420
R+TL+ I++P+ +L +F ++ G + N +++ G+ +AIG +VD AIV+VEN + +
Sbjct: 362 MRATLIPTIAVPVVLLGTFAILAAFGYSINTLTMFGMVLAIGLLVDDAIVVVENVERVMM 421

Query: 421 HYREQHNGATPTGEAHWELVRKSSVEVGPALFFSLLIITLSFVPVFALEAQEGRLFHPLA 480
E KS ++ AL ++++ F+P+ G ++ +
Sbjct: 422 ----------EDKLPPKEATEKSMSQIQGALVGIAMVLSAVFIPMAFFGGSTGAIYRQFS 471

Query: 481 YTKTFAMAASAILAITLIPVLMGYFVRGKIPDERK---------NPISRFLIAIYEPTLR 531
T AMA S ++A+ L P L ++ + + N + Y ++
Sbjct: 472 ITIVSAMALSVLVALILTPALCATLLKPVSAEHHENKGGFFGWFNTTFDHSVNHYTNSVG 531

Query: 532 LVLRFPKITILLAIVTLASAVYPMTKMGSEFMPELEEGDLLYMPTTLPSVSAGKAAEILQ 591
+L +L+ + +A V ++ S F+PE ++G L M + + ++L
Sbjct: 532 KILGSTGRYLLIYALIVAGMVVLFLRLPSSFLPEEDQGVFLTMIQLPAGATQERTQKVLD 591

Query: 592 QTDRLIKT--VPEVKRVFGKVGRAMTATDPAPLTMLETTIMLNPRDTW-REGMTLEGIIA 648
Q V+ VF G + + L P + + + E +I
Sbjct: 592 QVTDYYLKNEKANVESVFTVNGF---SFSGQAQNAGMAFVSLKPWEERNGDENSAEAVIH 648

Query: 649 ELQRTVKVPGMTNAWVQPIK-TRIDMLSTGVRTPVG-IKISGADIEELQRIGTEIEAVVS 706
+ ++ + + +V P I L T I +G + L + ++ + +
Sbjct: 649 RAKM--ELGKIRDGFVIPFNMPAIVELGTATGFDFELIDQAGLGHDALTQARNQLLGMAA 706

Query: 707 KLPGT-ESAFAQRTSGGRYIDIEPDLKNAARYGMTLKDIQDVVQMAIGGMQVGQSIQGQE 765
+ P + S +E D + A G++L DI + A+GG V I
Sbjct: 707 QHPASLVSVRPNGLEDTAQFKLEVDQEKAQALGVSLSDINQTISTALGGTYVNDFIDRGR 766

Query: 766 RYPINIRYPRELRDSIEKLEDLPVLTKTGKYLPLGNLASISISDGAPMLASENGRLISWV 825
+ ++ + R E ++ L V + G+ +P + G+P L NG +
Sbjct: 767 VKKLYVQADAKFRMLPEDVDKLYVRSANGEMVPFSAFTTSHWVYGSPRLERYNGLPSMEI 826

Query: 826 F-VDLKDISIGEYITSARAALDEQISLPPRYSYSFAGQYEYMQRVEAKMQLVVPLMLAVI 884
S G+ + + LP Y + G + + +V + V+
Sbjct: 827 QGEAAPGTSSGDAMALMENLASK---LPAGIGYDWTGMSYQERLSGNQAPALVAISFVVV 883

Query: 885 FMLLMMTFSSFIQASVIMLSLPFSLVGSAWLLYFLNFDFSVAVSVGMIALAGVAAEFGVV 944
F+ L + S+ +ML +P +VG N V VG++ G++A+ ++
Sbjct: 884 FLCLAALYESWSIPVSVMLVVPLGIVGVLLAATLFNQKNDVYFMVGLLTTIGLSAKNAIL 943

Query: 945 MQVYLNNSIRDRKLAGLYNKRSDLSEALIHGAVMRIRPKAMTVATIFFGLLPIMWGSGTG 1004
+ + + + + EA + MR+RP MT G+LP+ +G G
Sbjct: 944 IVEFAKDLMEKEGK--------GVVEATLMAVRMRLRPILMTSLAFILGVLPLAISNGAG 995

Query: 1005 NEVMQKIAAPMVGGMVTAPILSLFVIPAIYLLIYGR 1040
+ + ++GGMV+A +L++F +P +++I
Sbjct: 996 SGAQNAVGIGVMGGMVSATLLAIFFVPVFFVVIRRC 1031


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3992RTXTOXIND491e-08 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 49.4 bits (118), Expect = 1e-08
Identities = 56/339 (16%), Positives = 111/339 (32%), Gaps = 70/339 (20%)

Query: 75 GKVENIYVKPNQKVEAGQLIYDLDAEPYQIALNKALVAQETAKVN--------------- 119
V+ I VK + V G ++ L A + K + A++
Sbjct: 105 SIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIELNK 164

Query: 120 ---LSLSREDVKLALKQHEVAIADVSIT------KNQLNAASKDLAWKQKTLARFVEQNR 170
L L E + + EV I +NQ +L K+ + +
Sbjct: 165 LPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARIN 224

Query: 171 VVPDT-------------------ITKSQLDEQQTAVDLANAQVQTYSTQIEKAQMAEHT 211
+ I K + EQ+ A +++ Y +Q+E+ E
Sbjct: 225 RYENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQ---IESE 281

Query: 212 ALLNIEKSRLAVESRQSDLNSEH-----------ENVAQAQWNIDNTKIYAPTDGYVTNF 260
L E+ +L + ++++ + +A+ + + I AP V
Sbjct: 282 ILSAKEEYQLVTQLFKNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQL 341

Query: 261 -IMREGQYVGVA-PRMQMY-TNEKY-VLMRVNHQAIRNVKVGQLAEFASAVYPGK---VF 313
+ EG V A M + ++ V V ++ I + VGQ A +P
Sbjct: 342 KVHTEGGVVTTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYL 401

Query: 314 SAEVEGI------VEATGESQGRLVALDDNVRQTTGQNL 346
+V+ I + G ++++++N T +N+
Sbjct: 402 VGKVKNINLDAIEDQRLGLVFNVIISIEENCLSTGNKNI 440


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_3994HTHFIS300.012 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 30.2 bits (68), Expect = 0.012
Identities = 7/19 (36%), Positives = 15/19 (78%)

Query: 257 AALFGISRQQLQRRLQKLG 275
A L G++R L++++++LG
Sbjct: 456 ADLLGLNRNTLRKKIRELG 474


96Spea_4107Spea_4113N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_41070190.625150phosphopantetheine adenylyltransferase
Spea_4108-1191.765548pseudouridine synthase Rlu family protein
Spea_4109-1202.027968histidine kinase
Spea_4110-1191.965163two component transcriptional regulator
Spea_41110202.534716hypothetical protein
Spea_41120193.343941hypothetical protein
Spea_41130193.391299ABC transporter-like protein
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4107LPSBIOSNTHSS2235e-78 Lipopolysaccharide core biosynthesis protein signat...
		>LPSBIOSNTHSS#Lipopolysaccharide core biosynthesis protein

signature.
Length = 166

Score = 223 bits (569), Expect = 5e-78
Identities = 79/153 (51%), Positives = 107/153 (69%)

Query: 5 AIYPGTFDPVTNGHADLIERAANLFEHVIIGIAANPSKQPRFTLAERVELLKTVTAHLDN 64
AIYPG+FDP+T GH D+IER LF+ V + + NP+KQP F++ ER+E + AHL N
Sbjct: 3 AIYPGSFDPITFGHLDIIERGCRLFDQVYVAVLRNPNKQPMFSVQERLEQIAKAIAHLPN 62

Query: 65 VEVVGFSGLLVDFAKDQNASVLVRGLRAVSDFEYEFQLANMNRRLSPDLESVFLTPAEEN 124
+V F GL V++A+ + A ++RGLR +SDFE E Q+AN N+ L+ DLE+VFLT + E
Sbjct: 63 AQVDSFEGLTVNYARQRQAGAILRGLRVLSDFELELQMANTNKTLASDLETVFLTTSTEY 122

Query: 125 SFISSTLVKEVALHGGDVSQFVHIEVANALTKK 157
SF+SS+LVKEVA GG+V FV VA AL +
Sbjct: 123 SFLSSSLVKEVARFGGNVEHFVPSHVAAALYDQ 155


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4109PF06580310.010 Sensor histidine kinase
		>PF06580#Sensor histidine kinase

Length = 349

Score = 31.0 bits (70), Expect = 0.010
Identities = 18/99 (18%), Positives = 38/99 (38%), Gaps = 27/99 (27%)

Query: 356 LVDNAIKY----SGEGAEISIS----QNRNVISIQDNGPGIPEGSRDKVFERLVRLDPSR 407
LV+N IK+ +G +I + + +++ G + ++
Sbjct: 263 LVENGIKHGIAQLPQGGKILLKGTKDNGTVTLEVENTGSLALKNTK-------------- 308

Query: 408 HHKGTGLGLSMVKAILSR---HNAKIALTDNQPGLKVII 443
+ TG GL V+ L A+I L++ Q + ++
Sbjct: 309 --ESTGTGLQNVRERLQMLYGTEAQIKLSEKQGKVNAMV 345


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4110HTHFIS831e-20 FIS bacterial regulatory protein HTH signature.
		>HTHFIS#FIS bacterial regulatory protein HTH signature.

Length = 484

Score = 83.0 bits (205), Expect = 1e-20
Identities = 27/123 (21%), Positives = 56/123 (45%)

Query: 2 KILMVEDDATTIEYVVKGFVEQGHNIETATDGHQGLLLATSMKYDLIILDRMLPQLDGLK 61
IL+ +DDA + + G+++ ++ + DL++ D ++P +
Sbjct: 5 TILVADDDAAIRTVLNQALSRAGYDVRITSNAATLWRWIAAGDGDLVVTDVVMPDENAFD 64

Query: 62 LLAALRATGSQTPVLILSALSHVDERVKGLRAGGDDYMTKPFAFSELLVRAEKLMQRGES 121
LL ++ PVL++SA + +K G DY+ KPF +EL+ + + +
Sbjct: 65 LLPRIKKARPDLPVLVMSAQNTFMTAIKASEKGAYDYLPKPFDLTELIGIIGRALAEPKR 124

Query: 122 QPA 124
+P+
Sbjct: 125 RPS 127


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4113PF05272330.002 Virulence-associated E family protein
		>PF05272#Virulence-associated E family protein

Length = 892

Score = 32.7 bits (74), Expect = 0.002
Identities = 13/40 (32%), Positives = 17/40 (42%)

Query: 26 CKAGEVLAVVGPSGGGKSTLLRMIAGLTKPEDGEIRYGDK 65
CK + + G G GKSTL+ + GL D G
Sbjct: 593 CKFDYSVVLEGTGGIGKSTLINTLVGLDFFSDTHFDIGTG 632


97Spea_4201Spea_4206N        Y        NPathogenicity Island (unbiased-composition)
LocusTagDNBiasCDNBias%GCBiasProduct
Spea_42010224.014359ABC-2 type transporter
Spea_42020223.865133ABC transporter-like protein
Spea_42030183.261023hypothetical protein
Spea_42040172.784764outer membrane protein
Spea_42050172.759505TolC family type I secretion outer membrane
Spea_42060182.545930HlyD family type I secretion membrane fusion
ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4201ABC2TRNSPORT452e-07 ABC-2 type transport system membrane protein signat...
		>ABC2TRNSPORT#ABC-2 type transport system membrane protein

signature.
Length = 262

Score = 44.5 bits (105), Expect = 2e-07
Identities = 51/195 (26%), Positives = 91/195 (46%), Gaps = 14/195 (7%)

Query: 194 GVILTMTMIMFT----SAAIVRERERGNLEMLITTPIRSIELMLGKIIPYMFIGILQ--- 246
G++ T M T AA R + E ++ T +R +++LG++ L
Sbjct: 72 GMVATSAMTAATFETIYAAFGRMEGQRTWEAMLYTQLRLGDIVLGEMAWAATKAALAGAG 131

Query: 247 -VIIILGLGYSVFNVPINGSLLQLAGATLLFIMASLTLGLVISTIAKSQLQSMQMTIFVL 305
++ LGY+ + SLL L +A +LG+V++ +A S + V+
Sbjct: 132 IGVVAAALGYTQWL-----SLLYALPVIALTGLAFASLGMVVTALAPSYDYFIFYQTLVI 186

Query: 306 LPSILLSGFMFPYEGMPIEAQYIAEALPATHFMRLIRGVVLRDVEIIDMTYDVTWLAIFT 365
P + LSG +FP + +PI Q A LP +H + LIR ++L ++D+ V L I+
Sbjct: 187 TPILFLSGAVFPVDQLPIVFQTAARFLPLSHSIDLIRPIML-GHPVVDVCQHVGALCIYI 245

Query: 366 VIGLIVASMRFKKNL 380
VI +++ ++ L
Sbjct: 246 VIPFFLSTALLRRRL 260


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4203RTXTOXIND491e-08 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 49.1 bits (117), Expect = 1e-08
Identities = 28/163 (17%), Positives = 58/163 (35%), Gaps = 7/163 (4%)

Query: 42 SNEVVVALPVAQGSMVTKGTVLVQLDDTQQRAQVAKALADVAQSTANYEKLLKGARE-EE 100
N +V + V +G V KG VL++L A K + + Q+ + +R E
Sbjct: 103 ENSIVKEIIVKEGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSIEL 162

Query: 101 IAAARAKVSGAKATVQESEANYRRIASMAKDNLAS----KADLDRALASRDADTASLESA 156
K+ SE R+ S+ K+ ++ K + L + A+ ++ +
Sbjct: 163 NKLPELKLPDEPYFQNVSEEEVLRLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLAR 222

Query: 157 RENLRELVSGSREE--DIRFALANLQASEAVLLGEQKRLDDLT 197
L + D L ++ +L ++ + +
Sbjct: 223 INRYENLSRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAV 265


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4204OMPADOMAIN509e-10 OMPA domain signature.
		>OMPADOMAIN#OMPA domain signature.

Length = 346

Score = 50.3 bits (120), Expect = 9e-10
Identities = 26/98 (26%), Positives = 44/98 (44%), Gaps = 5/98 (5%)

Query: 66 TSTVSVKEDFRVIMFGFDKDTLAPEQADKWRGIIAGLVQKQSP--SLYLVGDTSVEGSED 123
T ++K D ++F F+K TL PE + + L S+ ++G T GS+
Sbjct: 212 TKHFTLKSD---VLFNFNKATLKPEGQAALDQLYSQLSNLDPKDGSVVVLGYTDRIGSDA 268

Query: 124 YNHALAKRRVDYITQLAVDQGFPASGIKEEVYFKQNHI 161
YN L++RR + + +G PA I + N +
Sbjct: 269 YNQGLSERRAQSVVDYLISKGIPADKISARGMGESNPV 306


ORFs having significant similarity with Known Virulence factors
LocusTagHitsScoreE-valueComments
Spea_4206RTXTOXIND2531e-81 Gram-negative bacterial RTX secretion protein D signat...
		>RTXTOXIND#Gram-negative bacterial RTX secretion protein D

signature.
Length = 478

Score = 253 bits (648), Expect = 1e-81
Identities = 95/428 (22%), Positives = 191/428 (44%), Gaps = 8/428 (1%)

Query: 13 AKRANQLIFLVAALIVVTLVWASFAKLEEVVVGEGMVVPTLAVQQIESLDGGILKQVLVR 72
++R + + + +V+ + + ++E V G + + ++I+ ++ I+K+++V+
Sbjct: 54 SRRPRLVAYFIMGFLVIAFILSVLGQVEIVATANGKLTHSGRSKEIKPIENSIVKEIIVK 113

Query: 73 EGQSVSAGEPLLLLDELRFASAYDEANIQAAALKRQKARLDAEISSVVIDDAASYWRDKV 132
EG+SV G+ LL L L + + + ++ R S+ + +
Sbjct: 114 EGESVRKGDVLLKLTALGAEADTLKTQSSLLQARLEQTRYQILSRSI-ELNKLPELKLPD 172

Query: 133 LIKPKAISALDVSVSTRSKAIYRSRLSQLSSQLEQSAQVIEQKVQAIEEGLITTQAQLSG 192
+ +S +V R ++ + + S +Q Q +++K L +
Sbjct: 173 EPYFQNVSEEEVL---RLTSLIKEQFSTWQNQKYQKELNLDKKRAERLTVLARINRYENL 229

Query: 193 LQLVKQEIVMTRAAVREGAVAELELLKLERDEIRLKGELSASKANGRQLRAAQNQAEAEY 252
++ K + + + + A+A+ +L+ E + EL K+ Q+ + A+ EY
Sbjct: 230 SRVEKSRLDDFSSLLHKQAIAKHAVLEQENKYVEAVNELRVYKSQLEQIESEILSAKEEY 289

Query: 253 LTVALDFLSRAEAERNEVINELNALTESIKTLADRLARTQIVSPINGNVTNILVRSIGAV 312
V F + + + + + LT + +R + I +P++ V + V + G V
Sbjct: 290 QLVTQLFKNEILDKLRQTTDNIGLLTLELAKNEERQQASVIRAPVSVKVQQLKVHTEGGV 349

Query: 313 VEPGESIMGIVPQDGALIIETRIAPKDIAFVHTGLQATVKFTAYDFVIYGGLKGEVIYVS 372
V E++M IVP+D L + + KDI F++ G A +K A+ + YG L G+V ++
Sbjct: 350 VTTAETLMVIVPEDDTLEVTALVQNKDIGFINVGQNAIIKVEAFPYTRYGYLVGKVKNIN 409

Query: 373 PDAQQLDDGTTYFEAHIKTEENVL----NGWPIISGMQASTDILTGEKTVLNYWLKPLLR 428
DA + F I EEN L P+ SGM + +I TG ++V++Y L PL
Sbjct: 410 LDAIEDQRLGLVFNVIISIEENCLSTGNKNIPLSSGMAVTAEIKTGMRSVISYLLSPLEE 469

Query: 429 AKANALRE 436
+ +LRE
Sbjct: 470 SVTESLRE 477



 
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