[Next-Generation Sequencing Book]
  • [Photo] Barbara Stranger • September 27, 2013

    BACKGROUND

    A position is available for a highly motivated postdoctoral researcher in the group of Barbara Stranger at The University of Chicago, in the Section of Genetic Medicine, and the Institute of Genomics and Systems Biology. Current research in the lab includes (1) transcriptional network and pathway analysis; (2) comparative and population genomics; (3) functional genomic data integration and data mining; and (4) detection of disease susceptibility genes/networks. Project topics include understanding the role of genetic and epigenetic variation on transcriptional regulation in healthy human cohorts, the contribution of that variation to higher order phenotypes including immune-mediated diseases, adverse pregnancy outcomes, and cancer, and elucidation of the evolutionary forces shaping functional variation in humans.

    RESPONSIBILITIES

    The researcher will be involved in analysis of a variety of types of human genomics data, including DNA-Seq, RNA-Seq, SNPs, DNA methylation, etc. Current research in the lab includes (1) transcriptional network and pathway analysis; (2) comparative and population genomics; (3) functional genomic data integration and data mining; and (4) detection of disease susceptibility genes/networks.

    Project topics include understanding the role of genetic and epigenetic variation on transcriptional regulation in healthy human cohorts, the contribution of that variation to higher order phenotypes including immune-mediated diseases, adverse pregnancy outcomes, and cancer, and elucidation of the evolutionary forces shaping functional variation in humans. The successful candidate will create automated pipelines for these purposes, and will create data processing programs and tools for general use.

    REQUIREMENTS

    Minimum Qualifications:
    • A Ph.D. in bioinformatics, computer science, genomics, population genetics, systems biology or other relevant fields of statistical biology
    • Must be familiar with existing genomics software and data archives.
    • Research experience (with strong first-author publications) in computational genomics, molecular evolution, population genetics, data integration, or a closely-related field
    • Strong analytical, statistical, quantitative, and computational/programming skills, ideally in C or C++ as well as in scripting languages such as perl, matlab, or R. Should be comfortable in a with large data sets, computer clusters, and databases.
    • Experience in analysis of DNA-seq, RNA-seq, and/or CHiP-seq data, as well as experience constructing complex biological networks
    • Creativity, curiosity, enthusiasm, and ability to work independently

    PREFERENCES

    • Background in population genetics
    • Knowledge of systems biology
    • Candidates with a multidisciplinary background, spanning both life sciences and quantitative sciences are especially encouraged to apply.

    HOW TO APPLY

    To formally apply, please send the following in PDF format to Barbara Stranger (bstranger AT uchicago.edu):

    1. A curriculum vitae, including names of 3 referees.
    2. A brief statement describing current and future research goals

    Our lab website is currently under construction, but informal inquiries are welcome.

    http://www.igsb.org/labs/barbara-stranger-lab/

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