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On Thursday, January 22nd, Stephen Altschul of NCBI will present the first part of a discussion of the statistical theory for local sequence alignments like those produced by the BLAST database search programs. It will cover the statistical parameters for local alignment scoring systems, and the formulas for calculating bit scores and asymptotic E-values and p-values from raw alignments scores.
This presentation will continue the following Thursday, January 29th. Part 2 will be a discussion of the considerations that go into the construction and selection of amino acid and nucleic acid scoring systems for pairwise local sequence alignment. It will briefly cover the PAM and BLOSUM series of amino acid substitution matrices, and also the concepts of relative entropy and efficiency for substitution matrices.
To sign up, click here:
Part 1: https://attendee.gotowebinar.com/register/5157554322839318274
Part 2: https://attendee.gotowebinar.com/register/1397330108961689090
Courtesy: NCBI
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Discussion forums: Education: Meet BLAST GURU online: Stephen Altschul of NCBI presents statistical theory
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