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    Education: Meet BLAST GURU online: Stephen Altschul of NCBI presents statistical theory
    Submitted by Prashanth N Suravajhala; posted on Friday, January 16, 2015


    On Thursday, January 22nd, Stephen Altschul of NCBI will present the first part of a discussion of the statistical theory for local sequence alignments like those produced by the BLAST database search programs. It will cover the statistical parameters for local alignment scoring systems, and the formulas for calculating bit scores and asymptotic E-values and p-values from raw alignments scores.

    This presentation will continue the following Thursday, January 29th. Part 2 will be a discussion of the considerations that go into the construction and selection of amino acid and nucleic acid scoring systems for pairwise local sequence alignment. It will briefly cover the PAM and BLOSUM series of amino acid substitution matrices, and also the concepts of relative entropy and efficiency for substitution matrices.

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    Part 1:
    Part 2:

    Courtesy: NCBI

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