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BACKGROUND

Job opportunities are available in the Laboratory of Medical Epigenetics at the Icahn School of Medicine at Mount Sinai (PI: Fatemeh Haghighi). Internationally regarded for its dedication to medical science, Mount Sinai is home to an array of leading research institutes, centers, and laboratories, all of which work toward rapidly translating advances in basic science into innovative patient care. Mount Sinai's Fishberg Department of Neuroscience, a major component of Mount Sinai's Friedman Brain Institute, sponsors innovative research in basic and translational neuroscience at the molecular, cellular, systems, and behavioral levels.

The Haghighi laboratory studies the epigenetic profile of human brain development and its emerging role in gene regulation, as well as its fundamental importance for our understanding of normal and pathological neuronal function. Next generation sequencing technologies now allow a global view of whole genome epigenetic profiles. Studies involve bioinformatic analysis of data from whole genome DNA methylation profiling via BS-seq to detect differentially methylated regions associated with disease and their potential function through genomic data mining. This interdisciplinary group offers an excellent environment to uncover new fundamental principles and regulatory mechanisms in this emerging area of genome biology.

RESPONSIBILITIES

Positions are available for Master or PhD level candidates with degrees in Statistics, Biostatistics, Bioinformatics, Computational Biology or other Quantitative fields who are interested in genetic and epigenetic research. The research group is highly multi-disciplinary. The successful candidate must have experience in programming and is preferred to be familiar with high-throughput analysis of biological data. Under the guidance of Dr. Fatemeh Haghighi (epigeneticist) and Dr. Yongchao Ge (statistician), this position involves integration of large-scale data sets, design and implementation of data processing pipelines, and analyses of genomic and epigenomic data.

REQUIREMENTS

Skills:

A strong quantitative background in computing, with a demonstrated ability to design and implement algorithms in working code
Coursework and practical experience in applying statistical and/or data mining approaches to complex and noisy biological data
Programming experience in a UNIX/Linux environment using programming languages such as R and Bioconductor
Experience in high-throughput data analysis and familiarity with widely used genomic databases and software
Excellent communication and teamwork skills to take advantage of the highly collaborative environment, adaptability and willingness to contribute to the overall goals of the research

COMPENSATION

Salary & Benefits: Commensurate with experience

HOW TO APPLY

Applicants should send a curriculum vitae/resume and provide contact information for references.

Fatemeh G. Haghighi, Ph.D.
Associate Professor, Department of Neuroscience
Icahn School of Medicine at Mount Sinai, New York, NY
Medical Epigenomics Laboratory
James J. Peters VA Medical Center, Bronx, NY
Email: fatemeh.haghighi[at]mssm.edu
Lab Website: http://neuroscience.mssm.edu/haghighi/

Discussion forums: Opportunity: Research Statistician/Bioinformatician in Epigenomics @ Icahn School of Medicine at Mount Sinai -- New York, NY (US)

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