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BACKGROUND

The Wellcome Trust Sanger Institute are seeking to recruit a Senior Bioinformatician who can facilitate the scientific work of the Pre-cancer group by leading the computational data analysis support for the team and their collaborators.

The Pre-cancer group studies how mutant cells evolve into dysplasias and cancers in human tissues and model systems (https://www.sanger.ac.uk/research/projects/precancer/). We are interested in how mutant clones compete with each other and interact with the cancer promoting environment during epithelial cancer evolution in order to develop new cancer prevention therapy. Our cross disciplinary approach exploits quantitative methods to link mutation with changes in cell dynamics (see links 1 and 2 below). Recent work includes developing a new deep sequencing technique to reveal a high density of clonal mutations in normal human epithelia, and the application of single cell analysis to reveal the molecular basis of stochastic cell fate. The group is a mixture of experimentalists and quantitative biologists. The post holder will be able to exploit extensive bioinformatics expertise within the Institute.

Many of our experiments involve the generation of large quantities of genome and exome sequencing, RNAseq and ChIPseq data which require strong computational skills to create high quality mutation calls and carry out statistical analysis to interpret the effects of mutation. Collaborating within the team to integrate genomic analysis with other types of data to resolve the cellular and tissue effects of mutations within tissues is an important part of what we do.

The post-holder must be a good communicator and be able to understand the scientific background and technical detail of the team's projects, and be to be proficient at devising and implementing software solutions and statistical analysis. This role would suit somebody with significant previous bioinformatics experience who wishes to gain knowledge of next-generation sequencing technologies and their application to clonal evolution, although experience with next-gen data is highly desirable. The successful candidate will work in conjunction with other computational biologists in the group and with other teams at the WTSI.

1) Doupé DP et al (2012) A single progenitor population switches behavior to maintain and repair esophageal epithelium. Science 337: 1091-1093
2) Alcolea MP et al (2014) Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change. Nat Cell Biol 16:615-622.

REQUIREMENTS

Essential Skills:

A degree or further degree related to biology/genetics/computer science/mathematics ideally at PhD level
Experience of bioinformatics and familiarity with genome data
Evidence of proficiency in Perl programming or another modern computer language
Strong UNIX/LINUX skills
Experience of researching/using/supporting external software packages
Ability to rapidly attain new technical skills and understanding of new technical concepts
A high level of communication skills to be able to elicit complex requirements from, and convey complex information to, group members with different levels of technical knowledge
Ability to quickly adapt to new problems and ideas
Ability to work unsupervised
Excellent problem-solving skills

Ideal Skills:

R and/or Matlab programming experience
Experience of working with biological analysis pipelines on multi-node compute clusters
Experience in pathway analysis software
Proficient in statistical analysis of genome-wide datasets

COMPENSATION

Salary range: GBP 30574 to GBP 38564 per annum plus excellent benefits

Our Benefits include: Defined Benefit Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Nursery and 25 days Annual Leave plus Bank Holidays. We also have a gym, two cafes, a nursery, dining facilities, and a free campus Bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

ABOUT US

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.

The Institute is located near Cambridge, UK on the stunning Wellcome Trust Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), the Centre for Therapeutic Target Validation, a Biodata Innovation Centre and will soon host Genomics England Limited's 100,000 Genomes Sequencing Centre. It is an excellent environment in which to work and collaborate with researchers on campus and around the world and benefit from cross-fertilisation of ideas.

To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. In addition the Campus is home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.

HOW TO APPLY

Please apply via:https://jobs.sanger.ac.uk/wd/plsql/wd_portal.show_job?p_web_site_id=1764&p_web_page_id=216625

Please provide a CV and cover letter.

DEADLINE

Closing date: 31st May 2015

Discussion forums: Opportunity: Senior Bioinformatician (Pre-Cancer Group) @ Wellcome Trust Sanger Institute -- Hinxton/Cambridge, UK

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