DESCRIPTION

Areas of Interest: Single-Cell Genomics, Epigenetics, Intratumoral Heterogeneity, Nucleosome Organization, Computational Biology.

A laboratory at the newly-formed Department of Biomedical Informatics at the Harvard Medical School (HMS) is looking to recruit several postdoctoral fellows interested in pursuing one or more of the following topics in computational biology:

I. Single-Cell Genomics. The fellow will be charged with developing novel statistical approaches to analysis of single-cell genomic data, mathematical modeling of cellular processes, as well as applications of such techniques to studies healthy and diseased tissues. Strong background in statistics, modeling of stochastic processes and multicellular systems is desired.

II. Computational analysis of epigenetic mechanisms disrupted in cancer and other disease-disrupted tissues. The fellow will be responsible for developing and applying computational methods for integrative analysis of genome-wide epigenetic, transcriptional and proteomic data, aiming to identify specific factors and molecular mechanisms underlying misregulation of the epigenetic states in several types of human cancer. The ideal candidate should have strong quantitative background, ample experience with analysis of sequencing assays, and strong interest in cancer biology.

III. Computational analysis of nucleosome organization. The fellow will be part of the central analysis group for the extensive 4D-nucleus consortium project funded by the NIH. The efforts will be focused on development of analysis techniques for the next generation of experimental methods for measuring organization and dynamics of the eukaryotic nucleus that are being developed by the members of the consortia. Experience with analysis of Hi-C and relevant imaging data is strongly preferred.

All of the projects are being conducted in close cooperation with the expert bench-side laboratories, providing an excellent opportunity for collaborative research. The Harvard Medical School and the Department also provides rich scientific environment, with a number of relevant seminar series, invited speakers, and many neighboring laboratories working on related projects. Please see http://pklab.med.harvard.edu for additional information about the laboratory.

PhD in Computational Biology, Statistics, Physics or other related discipline is required. A strong record of publications in the field is desired.

ABOUT US

Department of Biomedical Informatics has been recently formed at the Harvard Medical School to lead development of computational and informatics techniques to address pertinent challenges in modern biological sciences and medicine. The Department's faculty conduct research at the intersection of biomedicine and information sciences, including bioinformatics, functional genomics, translational medicine, and clinical knowledge management. The Department also hosts the Bioinformatics & Integrative Genomics PhD program (sponsored by NHGRI) and the Biomedical Informatics Masters program.

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