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    Opportunity: Bioinformatics Analyst II (#629171) (NCI) @ Leidos Biomedical Research -- Frederick, MD (US)
    Submitted by Karen Rodgers; posted on Thursday, July 14, 2016


    Company Information:
    Leidos Biomedical Research, Inc. (LBRI), a wholly owned subsidiary of Leidos, operates the Frederick National Laboratory for Cancer Research (FNLCR). FNLCR is a Federally Funded Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI). It is the only FFRDC dedicated to biomedical research. Through its status as an FFRDC, FNLCR provides NCI and others with a unique national resource to accelerate the development and delivery of effective preventive, diagnostic, and therapeutic products for cancer and AIDS.

    The breadth of FNLCR's activities spans the research and development spectrum, including investigator-initiated, hypothesis-driven research into cancer and AIDS; advanced technology programs focused on genetics and genomics, proteins and proteomics, imaging, nanotechnology, bioinformatics, and laboratory animal sciences; clinical operations in support of NCI and National Institute of Allergy and Infectious Diseases (NIAID)-sponsored clinical trials, as well as NCI drug discovery and development efforts; and management and operations of biopharmaceutical development and manufacturing programs under current Good Manufacturing Practice conditions for NCI and NIAID. Administrative, procurement, financial, safety, and facilities support is provided to these R&D activities through state-of-the-art business processes. LBRI has approximately 1,900 employees and manages an annual operating budget of approximately $450M.

    For more information about Leidos Biomedical Research Inc., please visit our webpage at


    Program Description:
    The Molecular Characterization Laboratory (MoCha) is part of Leidos Biomedical Research's Clinical Research Directorate (CRD) at the Frederick National Laboratory for Cancer Research. The MoCha Laboratory is responsible for providing high-level research in support of the NCI-Cancer Diagnostics Program (CDP) within the Division of Cancer Treatment and Diagnosis (DCTD). MoCha is charged with the development and application of genomic assays for use in medical research and diagnostics for DCTD-sponsored national extramural clinical trials.

    The Molecular Characterization Laboratory (MoCha) focuses on development and application of novel genomic assays for clinical applications.

    Job Description:
    The Bioinformatics Analyst II will: 1) be responsible for providing substantial bioinformatics support for the MoCha clinical laboratory, including the analysis and interpretation of high throughput genomic data, 2) provide expertise in the biological interpretation of results, including mutation impact assessment, expression analysis, statistics support and prioritization of identified loci/genes lists, classification model building and determining correlation with clinical data derived from patients, 3) interact with investigators throughout the entire experimental process from study design to result interpretation including manuscript preparation, 4) provide support to lab staff in the application of basic data analysis and study design, 5) provide bioinformatics knowledge as a shared team resource, 6) maintain and track complex data for multiple projects, 7) work with lab managers to update genetic information in databases, 8) work closely with clinical lab staff to provide computation resources and to support data analysis and storage, and 9) coordinate and integrate software applications and databases within the larger group including the Bethesda, Frederick, and Shady Grove NCI campuses.


    Basic Qualifications:
    • Possession of a Bachelor's degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) in biomedical science/bioinformatics/math/statistics/computer related field or four (4) years related experience in lieu of degree
    • Foreign degrees must be evaluated for U.S. equivalency
    • A minimum of two (2) years of progressively responsible relevant experience
    • Experience in next generation sequence analysis (NGS) including quality metrics, mapping, variant calling and biological interpretation
    • Experience analyzing large genomic data sets including integration with data available from public or private sources
    • Hands-on experience in data processing and analyzing sequencing, expression and other array data including quality and biological assessment
    • Proficiency in Unix (Linux) system, scripting and programming languages such as Shell, R, Python, JavaScript, Perl, Java, SQL and bioinformatics tools and database management
    • Experience performing statistical analysis of complex biological data
    • Strong organizational skills and information tracking experience for data with complex structures


    Preferred Qualifications:
    • Peer reviewed publications demonstrating knowledge of the biology of cancer
    • Experience with Ion Torrent systems, including the Ion Reporter system
    • In-depth understanding in molecular biology techniques, oncology and clinical research
    • Experience in data integration, database construction, application development and visualization
    • Experience in porting applications to a web environment and working with workflow tools and applications
    • Excellent communication skills (written and oral)
    • Ability to work effectively in a team-oriented environment
    • Ability to identify and solve complex problems


    Full Time


    Frederick, MD


    Leidos Overview:
    Leidos is an applied solutions company focused on markets that are seeing converging business and technological trends, and address basic, enduring human needs: defense and national security, health and life sciences, and energy, engineering and infrastructure. The Company's approximately 20,000 employees serve customers in the U.S. Department of Defense, the intelligence community, the U.S. Department of Homeland Security, other U.S. Government civil agencies and commercial health and engineering markets.


    Please visit[...]NCI)/


    Qualified women, minorities, individuals with disabilities and protected veterans are encouraged to apply. Leidos is an Equal Opportunity Employer.

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