[Next-Generation Sequencing Book]
  • [Photo] Sam Bowker • August 16, 2016

    BACKGROUND

    A computational position has become available which involves developing computational and statistical methods in a project within the Cancer Genomics Programme. The post holder will have responsibilities to develop computational and statistical methods for a project exploring somatic mutations associated with aberrations in DNA repair pathways. We are generating human iPSC lines from patients with germline mutations in DNA repair/replication pathways and generating parallel CRISPr/CAS-9 edited lines of the same genes. The over-arching objective is to explore mutational signatures in the context of the biological mechanisms associated with DNA repair, by integrating cellular/molecular approaches with genome-wide assays including genomic sequencing, RNA-seq and ChIP-seq.

    A detailed role profile and further information regarding the new program can be found on our website at: http://www.sanger.ac.uk

    REQUIREMENTS

    Essential Skills:
    We welcome candidates with a solid expertise in statistics/computational biology/population genetics or genomics/computer science/physics, in addition to strong quantitative skills. Programming skills and experience in handling large datasets is essential. Candidates with experience in genome-wide assays and genomics/molecular biology are encouraged to apply. The ability to communicate effectively, organize your own time and work independently are essential.

    PREFERENCES

    Ideal Skills:
    • Experience with analysis of -omics data sets
    • Previous experience with QTL analysis
    • Previous experience with stem cells
    • Some understanding of genomics assays (RNA-seq, ChIP, genome sequencing) would be advantageous

    COMPENSATION

    Salary range: £30,655 - £38,428 pa dependent on experience plus excellent benefits

    Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

    TERMS

    Fixed-term 12 months

    ABOUT US

    The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited's 100,000 Genomes Sequencing Centre.

    The Campus is also home to the Wellcome Genome Campus Courses, Conferences and Public Engagement (CCPE) programme. The CCPE programme delivers training and engagement focussed around genomics, its applications, and implications. Its vision is to inspire a range of audiences both on the Campus and beyond it, and make the world of genomics open and accessible to all. To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. In addition the Campus is home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.

    HOW TO APPLY

    Please visit https://jobs.sanger.ac.uk/wd/plsql/wd_portal.show_job?p_web_site_id=1764&p_web_page_id=273050

    Please include a covering letter and CV with your application.

    DEADLINE

    Closing date for applications: 23rd August 2016, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.

    POLICY

    Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

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