BACKGROUND:
A postdoctoral position is available in Computational Genomics at the Wellcome Trust Sanger Institute under the leadership of Dr Daniel Gaffney. The long-term goal of the lab is to understand how genetic changes influence gene regulation, using a combination of statistical and experimental approaches. One current theme of our group is in the area of gene-environment interactions. We are currently generating RNA-seq and ATAC-seq profiles in immune cells across large numbers of stimulated states, and in hundreds of individuals, to discover regulatory variants whose function is normally "hidden" in naïve cell states.

The applicant will have the opportunity to develop novel methods for the analysis of gene-environment interactions, and apply these methods to a novel data set generated in our own group. The successful applicant will also have the opportunity to directly test computational results experimentally using CRISPR/Cas9 genome editing, working with the experimental members of the group. The successful applicant will be expected to develop his or her own interests as the project progresses.

Candidates in Biology with a strong background in quantitative analysis and population genetics are strongly encouraged to apply. We also welcome candidates with a background in Physics, Statistics or Computer Science with strong interests in computational biology. Excellent programming skills, experience with very large data sets and an ability to work as part of a team are essential. The post-holder will work as part of the Gaffney group at WTSI, for more information on the group's research see: http://www.sanger.ac.uk/science/groups/gaffney-group

REQUIREMENTS:
Essential Skills:

• PhD in a relevant subject area (Computational Biology, Population Genetics/Genomics, Computer Science, Physics)
• Strong publishing record
• Strong statistical and quantitative skills and familiarity with statistical modeling and software
• Excellent programming skills (C, C++, Perl, Python, Java) and extensive experience of UNIX/Linux and cluster computing
• Ability to communicate ideas and results effectively
• Ability to work well with other team members
• Ability to work to tight deadlines

Ideal Skills:

• Previous experience in population genetic analysis
• Experience with analysis of -omics data sets
• Some familiarity with the stem cell biology

COMPENSATION:
Salary range: £30655 to £38428 dependent on experience

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

TERMS:
Fixed-term, 3 years

ABOUT US:
Postdoctoral Fellows are typically in their first or second postdoctoral position as part of a period of early career research training. Campus Life The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited's 100,000 Genomes Sequencing Centre.

The Campus is also home to the Wellcome Genome Campus Courses, Conferences and Public Engagement (CCPE) programme. The CCPE programme delivers training and engagement focussed around genomics, its applications, and implications. Its vision is to inspire a range of audiences both on the Campus and beyond it, and make the world of genomics open and accessible to all. To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. In addition the Campus is home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.

HOW TO APPLY:
Please include a covering letter and CV with your application.

Application Link: https://jobs.sanger.ac.uk/wd/plsql/wd_portal.show_job?p_web_site_id=1764&p_web_page_id=274793

DEADLINE:
Closing date for applications: 11th September 2016, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.

POLICY:
Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.