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    Resources: Cello: Genetic circuit design automation
    Submitted by Prashanth N Suravajhala; posted on Thursday, August 25, 2016

    Submitter

    EXCERPT

    The Cello input is a high-level logic specification written in Verilog, a hardware description language. The code is parsed to generate a truth table, and logic synthesis produces a circuit diagram with the genetically available gate types to implement the truth table. The gates in the circuit are assigned using experimentally characterized genetic gates. In assignment, a predicted circuit score guides a breadth-first search, or a Monte Carlo simulated annealing search. The assignment with the highest score is chosen, and this assignment can be physically implemented in a combinatorial number of different genetic layouts. The Eugene language is used for rule-based constrained combinatorial design of one or more final DNA sequence(s) for the designed circuit.

    AVAILABILITY

    www.cellocad.org
    github.com/CIDARLAB/cello

    ARTICLE

    Nielsen, Alec A.K., et al. 2016. "Genetic circuit design automation." Science 352(6281). dx.doi.org/10.1[...]c7341

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