Resources: Cello: Genetic circuit design automation
Submitted by Prashanth N Suravajhala;
posted on Thursday, August 25, 2016
|
EXCERPT
> The Cello input is a high-level logic specification written in Verilog, a hardware description language. The code is parsed to generate a truth table, and logic synthesis produces a circuit diagram with the genetically available gate types to implement the truth table. The gates in the circuit are assigned using experimentally characterized genetic gates. In assignment, a predicted circuit score guides a breadth-first search, or a Monte Carlo simulated annealing search. The assignment with the highest score is chosen, and this assignment can be physically implemented in a combinatorial number of different genetic layouts. The Eugene language is used for rule-based constrained combinatorial design of one or more final DNA sequence(s) for the designed circuit.
|
|
![[Next-Generation Sequencing Book]](https://www.bioinformatics.org/images/ack_banners/NGS-Book-1-728x90.png)