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BACKGROUND

An exciting Software Development opportunity has become available working with Dr Serena Nik-Zainal on several projects, including the clinical study INSIGNIA, which forms part of the research initiative COMSIG. The COMSIG consortium, funded by a Wellcome Trust Strategic Award, is focused on exploring the mutational signatures of DNA damage and repair processes. This includes work performed across a range of model organisms (yeast, worm), as well human studies such as INSIGNIA, which are a key focus for Dr Nik-Zainal's team. As part of this we are generating human iPSC lines from patients with germline mutations in DNA repair/replication pathways and generating parallel CRISPr/CAS-9 edited iPSC lines of the same genes. The over-arching objective is to explore mutational signatures in the context of the biological mechanisms associated with DNA repair, by integrating cellular/molecular approaches with genome-wide assays including genomic sequencing, RNA-seq and ChIP-seq.

The successful candidate will be embedded in a multidisciplinary team and will be tasked with further contributing towards developing the analysis pipelines for this project and towards developing the public-facing website/database for the mutational signatures projects. The role involves working at the interface between scientific and IT staff on these projects to ensure efficient analysis of the DNA sequencing data sets. This website/database in envisaged as a reference resource for mutational signatures in the future. The position would suit a Bioinformatician/Software Developer who enjoys developing or enhancing software tools for analysis of complex NGS biological data sets and to make these efficient, visually appealing and interpretable by the scientific/clinical community. We are looking for an individual who enjoys working in a multi-disciplinary team environment to help solve complex IT issues which will ultimately aid our understanding of mutational processes in human cells.

REQUIREMENTS

Essential Skills:

Good degree in Bioinformatics or Computer Science with a scientific background
Software development skills (using Perl and/or Python)
ORACLE/MySQL databases
Experience of handling Next Generation sequencing data
LSF or Open Grid scheduling software
Experience working, developing and compiling software tools in a UNIX/LINUX environment
Enjoy working as part of a team

PREFERENCES

Ideal Skills:

Software development using a compiled language (C,C++,Java)
Experience of statistical analysis in a bioinformatics (in R)
Experience of workflow management IT systems
Experience of VMware, OpenStack or Amazon Web Services (AWS)
Experience of working in an Agile Software Development Group
Web development using Perl, Java, HTML(5), CSS, JavaScript
Background in cancer genetics

COMPENSATION

Salary range: £31,033 to £39,142 pa depending on experience.

Our Benefits include: Defined Contribution Pension Scheme, Group Income Protection, Healthcare scheme, Childcare Vouchers, Workplace Nursery and 25 days Annual Leave, increasing by one day per year up to a maximum of 30, plus Bank Holidays. We also have a gym, two cafes, dining facilities, and a free campus bus service. Our thriving Sports and Social Club provides many opportunities to meet with people working across the campus.

ABOUT US

The Sanger Institute is a charitably funded research centre focused on understanding the role of genetics in health and disease. We use state of the art large-scale genomic approaches to drive world-leading projects to uncover the basis of genetic and infectious disease. Our goal is to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus. This growing and dynamic site is the British hub of genomic science. It hosts the European Bioinformatics Institute (EBI), Open Targets, a Biodata Innovation Centre and will soon host Genomics England Limited's 100,000 Genomes Sequencing Centre.

The Campus is also home to the Wellcome Genome Campus Courses, Conferences and Public Engagement (CCPE) programme. The CCPE programme delivers training and engagement focussed around genomics, its applications, and implications. Its vision is to inspire a range of audiences both on the Campus and beyond it, and make the world of genomics open and accessible to all. To help researchers to develop their skills and networks, the Institute hosts a range of scientific seminars with internal and invited speakers, scientific group meetings and skills development workshops. In addition the Campus is home to the Wellcome Trust Advanced Course and Scientific Conferences programme and the Wellcome Trust Conference Centre.

HOW TO APPLY

Please include a covering letter and CV with your application via: https://jobs.sanger.ac.uk/wd/plsql/wd_portal.show_job?p_web_site_id=1764&p_web_page_id=279950

DEADLINE

Closing date for applications: 19th October 2016, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.

POLICY

Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

Discussion forums: Opportunity: Senior Bioinformatician COMSIG @ Wellcome Trust Sanger Institute -- Hinxton/Cambridge, UK

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