BACKGROUND:
An exciting position in cancer bioinformatics with focus on normal and malignant hematopoiesis as well as cancer stem cell models is available in the Porse Group, at the Biotech Research and Innovation Centre (BRIC) in Copenhagen.

We are seeking an innovative, PhD level computational biologist to join a group that generates omics data using the latest technologies (RNA-seq, single cell RNA-seq, CHiP-seq, proteomics) and has expertise in expression profiling, machine learning, epigenetic, visualisation and next generation sequencing data.

Our Research/The Group:
Several cancers, including acute myeloid leukemias (AML), are maintained by Cancer Stem Cells (CSCs). Similar to normal stem cells, CSCs are able to self-renew and are thus the cells that need to be targeted in order to efficiently eradicate the disease. The focus of the Porse group is therefore to study cancer from a stem-cell centric viewpoint. Specifically, we address the molecular mechanisms governing both normal and malignant hematopoiesis with the aim to identify novel targets for future therapeutic intervention in patients suffering from AML.

Key publications relevant for computational biologists:
Paul F et al., Cell 2015, 163, 1663-77
Pundhir S, Nucleic Acids Research 2016, 44, 4037-51
Bagger FO et al., Nucleic Acids Research (2016), 44, D917-24
Rapin N. et al., Blood 2014, 123, 894-904
Vitting-Seerup K et al., BMC Bioinformatics 2014, 15, 81
Jakobsen JS et al., Genome Research 2013, 23, 592-603
Weischenfeldt J. et al, Genome Biology 2012, 13, R35

Project/The research project(s):
The successful candidate will join our bioinformatics team, currently consisting of two persons. Your time will be shared between involvement/support in projects originating from our wet lab and own projects, on which you can dedicate 20-30% of your time. You will be expected to come up with you own computational research questions and publish your results in peer-reviewed academic journals.

Start: Preferably June 2017 or after agreement
Duration: Two years, with a possibility for extension

RESPONSIBILITIES:
Qualifications:
We expect you to be a highly motivated and highly ambitious scientist with the following qualifications:

• A PhD in bioinformatics or computational biology
• Ability to grasp complex problems and deliver creative, practical solutions
• Strong communication and collaboration skills, including the ability to work well in a diverse academic setting, and to balance scientific and day-to-day needs
• Ability to work in a team of multidisciplinary scientists, and operate effectively in a matrix environment; team player yet able to work independently with minimal direction
• Experience with data analysis, especially involving large complex data sets
• Previous experience with next generation sequencing data workflow and analysis
• Excellent English skills written and spoken

PREFERENCES:
Preferred Experience and Skills:

• Experience including a combination of scripting, programming, machine learning, database design, and statistical analysis, as well as familiarity with cluster and/or cloud-based computing environments.
• Strong background in molecular biology and genetics, especially related to disease and drug development will be considered an advantage.

For further information regarding the position, please contact Prof. Bo Porse by email at bo.porse[at]bric.ku.dk.

TERMS:
Terms of Salary and Employment:
Salary, pension and terms of employment will be in accordance with the agreement between the Ministry of Finance and The Academics Central organization. Currently, the monthly salary starts at 32.351 DKK/ca. 4.250 Euro plus pension. Depending on qualifications, a higher salary may be negotiated.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the "Memorandum on Job Structure for Academic Staff at the Universities" of June 28, 2013.

LOCALE:
Place of Employment:
The employment is at BRIC, University of Copenhagen. BRIC is located in the Biocenter, close to the centre of Copenhagen. We offer creative and stimulating working conditions in a dynamic and international research environment. Our research facilities include modern laboratories and a number of core facilities shared between the 23 research groups at BRIC and the neighboring Finsen Laboratory. We have weekly journal clubs, data clubs, seminars with invited speakers and a young researchers club ASAP and our own PhD programme, MoMeD and our own Postdoc Career Programme. BRIC actively participates in the European alliance, EU-life consisting of 13 excellent life science research institutions http://eu-life.eu

Please read more about the Porse research group and BRIC on http://www.bric.ku.dk

HOW TO APPLY:
Your application must be submitted electronically by clicking `Apply now' below or via BRIC's website on http://www.bric.ku.dk/jobs/. The application must include the following documents/attachments – all in PDF format:

• Motivated letter of application (max. one page)
• CV incl. education, work/research experience, language skills and other skills relevant for the position
• A certified/signed copy of a) PhD certificate and b) Master of Science certificate. If the PhD is not completed, a written statement from the supervisor will do
• List of publications

Letters of recommendation:
Furthermore, the applicant should provide two letters of recommendation. To be taken into consideration, the letter must be signed by the supporting person on paper with institutional letter head and in PDF-format. The letters should be received before deadline on jobs[at]bric.ku.dk with subject "candidate name- bioinformatics-postdoc-Porse-2017"; preferably by the supporting person. Please make sure that an easy match between the recommendation letter and the individual applicant is possible.

Application deadline: March 16th, 2017.

We reserve the right not to consider material received after the deadline, and not to consider applications or letters of recommendation that do not live up to the above-mentioned requirements.

The Further Process:
Shortlist: After expiry of the application deadline, the superior with power to appoint selects a number of applicants for assessment on the advice of the Appointments Committee. All applicants are immediately notified whether their application has been passed for assessment. Applicants who were not passed for assessment should not expect further with regard to their application unless the shortlist is revised.

Assessment: The selected applications will be assessed according to the Ministry Order on the Appointment of Academic Staff at Universities 2012 and the University of Copenhagen's guidelines 2013. The Assessment Committee makes a non-prioritized assessment of the academic qualifications and experience with respect to the above mentioned area of research, techniques, skills and other requirements listed in the advertisement.

You can read about the recruitment process at http://employment.ku.dk/faculty/

BRIC and University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of personal background.

Apply online: http://employment.ku.dk/all-vacancies/?show=886349

Part of the International Alliance of Research Universities (IARU), and among Europe's top-ranking universities, the University of Copenhagen promotes research and teaching of the highest international standard. Rich in tradition and modern in outlook, the University gives students and staff the opportunity to cultivate their talent in an ambitious and informal environment. An effective organisation – with good working conditions and a collaborative work culture – creates the ideal framework for a successful academic career.