[Next-Generation Sequencing Book]
  • [Photo] Sam Bowker • February 23, 2017

    BACKGROUND

    The Wellcome Trust Sanger Institute conducts cutting edge genomic research and the focus of our group is to develop new methods and models that will further our understanding of gene expression and gene regulation. We are looking for a dynamic and motivated Postdoctoral Fellow to join the Hemberg Faculty Team and undertake research into neurobiology and bioinformatics. The successful candidate will be expected to contribute to the formulation and submission of research publications and research proposals as well as help manage and direct this complex and challenging project, as opportunities allow.

    RESPONSIBILITIES

    The primary goal of this position is to be involved in the Open Targets funded study of human neuronal cultures derived from patients with familial Alzheimer's disease (AD) mutations using single-cell RNA-seq (scRNA-seq). The main goal is to characterize and compare different cell-types for mutants and controls to identify the pathways that result in early onset AD. This will require using established pipelines and software for analysing scRNA-seq data, as well as developing novel methods for identifying differentially expressed genes and inferring gene regulatory networks. The project is a collaboration with the Livesey and Teichmann labs, and an important aspect of this role will be to interact with members of those groups for the analysis and interpretation of the data.

    REQUIREMENTS

    • PhD (or equivalent) in Mathematics, Physics or Computer Science
    • Ability to independently solve complex scientific/technical problems and manage scientific projects
    • Excellent communication skills
    • Self-motivation and diligence
    • Ability to work with an international group of scientists
    • Good publication track record

    PREFERENCES

    • Advanced bioinformatics skills in NGS data analysis
    • Good understanding of genomics and molecular biology
    • Strong programming skills
    • Experience with single-cell genomics

    TERMS

    Fixed Term contract.

    LOCALE

    Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1RQ

    COMPENSATION

    Salary £31,115 to £39,004 plus excellent benefits.

    HOW TO APPLY

    Click on the link: https://jobs.sanger.ac.uk/wd/plsql/wd_portal.show_job?p_web_site_id=1764&p_web_page_id=304977

    DEADLINE

    Closing date for applications: 23rd March 2017 , however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline

    POLICY

    Please include a covering letter and CV with your application.

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