DESCRIPTION

The Kubicek laboratory and Platform Austria for Chemical Biology PLACEBO at CeMM, the Research Center for Molecular Medicine of the Austrian Academy of Sciences in Vienna, is recruiting a Data Analyst working at the interface of chemical biology and epigenetics.

The Position: The successful applicant will systematically analyze and integrate large-scale data sets, including (epi)genomics data and chemical screening results. The data originate from our ongoing projects in chemical biology and epigenetics, as highlighted by our recent publications of the first single-cell transcriptomes from primary human pancreatic islets (Li et. al EMBO Rep. 2016), the identification of artemisinins as compounds impacting alpha cell identity (Li et al. Cell 2017), and novel functional screening for chromatin states (Sdelci et al. Nat. Chem. Biol. 2017). The goal of the position is develop an optimized data structure, build systematic analysis pipelines, and set data in context with publically available external datasets.

The Candidate: The successful candidate hold a degree in Computational Biology (Bachelor, Master or PhD degree), and have a proven track record in data integration, analysis and statistics. Expertise in programs such as R, Python, Matlab is a requirement, and cheminformatics skills (Schroedinger, MOE, LigandScout, Pipeline Pilot) are considered a plus. The working language at CeMM is English, and excellent written and oral communication skills as well as high accuracy, reliability and excellent interpersonal and organizational skills are a requirement.

The Laboratory: The Kubicek laboratory is working on the role of chromatin in the definition of cell types and cell states, and the use of chemistry to modulate epigenetic states. Projects focus on development of chromatin-targeting chemical probes, chromatin-modifying enzymes as synthetic lethal targets in cancer, host factors in infectious disease and transdifferentiation to insulin-producing beta cells.

Furthermore, the laboratory hosts the Platform Austria for Chemical Biology PLACEBO, a unique chemical screening infrastructure with a collection of 90,000 small molecule compounds. In a unique automated setup, the platform conducts up to 40 high-throughput screens in collaboration with internal and external researchers. In addition, we apply proteomics, metabolomics, chemistry, mass spectrometry, bioinformatics, and next generation sequencing to address our research questions. The selected candidate will have the opportunity to work in an innovative research environment and collaborate closely with other groups at CeMM.

The Institute: CeMM is a biomedical flagship institute in the heart of Europe, Vienna. We are committed to highest scientific standards and provide an international environment representing approximately 40 nationalities. The working language is English. CeMM has been ranked by The Scientist as one of the Best Places to Work Academia worldwide (link: http://goo.gl/51VMO). In the past 3 years CeMM groups published numerous ground-breaking studies in prestigious journals such as Science, Cell, Nature, New England Journal of Medicine, Nature Immunology, Immunity etc. CeMM is located within the medical campus of Vienna and operates several technology platforms (chemical biological screening, proteomics, metabolomics, next-generation sequencing) as well as extensive bioinformatics infrastructure.

DESCRIPTION

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