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Opportunity: Bioinformatician / Senior Bioinformatician @ Wellcome Trust Sanger Institute -- Hinxton/Cambridge, UK
Submitted by Sam Bowker; posted on Friday, June 30, 2017
BACKGROUND
We are looking for an enthusiastic and skilled Bioinformatician/Senior Bioinformatician to join the Soranzo team at the Wellcome Trust Sanger Institute (http://www.sanger.ac.uk/research/faculty/nsoranzo/). The post will suit an ambitious and talented individual who is interested in applying his/her skills at the interface of human disease and regulatory genomics.
The Soranzo team at the Sanger Institute studies genomic predisposition to cardiometabolic risk. In the last ten years, we have led international efforts to discover genetic variants associated with both established and emerging risk factors in cardiovascular disease, diabetes and immunity. Distinguishing features of our research are the focus on large-scale science, the use of genome sequencing for genomic exploration, and a focus on high-dimensional (`omic') phenotypes, including metabolomics and gene expression phenotypes.
RESPONSIBILITIES
This position will be primarily responsible for supporting the computational needs of the team, and for the processing, storage and visualisation of large-scale biological datasets. The primary aim of this work will be to develop computational tools, databases and web-based interfaces for rapid retrieval and visualisation of genetic association datasets in the context of functional genomic data. Further, the candidate will be responsible for the storage and maintenance of a large number of genomic datasets. Depending on skills and interests, the candidate will also have the opportunity to be involved in the processing and analysis of large-scale genomic datasets based on next generation sequencing, including whole genome sequencing, gene expression, promoter capture, histone modifications, methylation and transcription factor data. These efforts will inform efforts to characterise the impact of sequence variation through large-scale functional genomic explorations. The post-holder is expected to work in a highly independent manner, and to support the generation of high-impact publications.
This researcher will be embedded an interdisciplinary team of computational scientists, bioinformaticians, statisticians and wet lab scientists seeking to study the functional impact of rare human sequence variation in complex traits and disease.
REQUIREMENTS
- A PhD in computer science, computational biology, biostatistics, bioinformatics, or a similar numerical discipline is desired although not strictly necessary
- Demonstrated programming skills in shell scripting (e.g. bash, tcsh)
- Demonstrated programming skills in an object-oriented language (C, C++, PERL, Python or similar)
- Good experience of design and use of relational databases, including MySQL, SQL and Oracle
- Experience of visualizing and reporting data, on and off the web
- Good communication skills directly with scientific researchers regarding programming and analysis requirements
- Documented experience in data parsing, cleansing, data modelling, analysis, and database design and implementation
- Excellent communication, organisational and problem-solving skills
- Ability to work to tight timelines, both independently and as part of a team
- Ability to communicate efficiently with a diverse array of scientific expertise
- Enthusiasm, commitment and attention to detail
- The ability to anticipate needs and problems while creating solutions
PREFERENCES
- Knowledge of biological analysis pipelines
- Knowledge of leading NGS processing techniques for the identification of SNPs, INDELs and structural variants
- Direct experience processing NGS data is a plus.
- Experience providing advice, training and support to other researchers in the areas of bioinformatics and data analysis
COMPENSATION
Salary £31,498 to £39,729 per annum depending on experience (Senior Bioinformatician)
Salary £24,589 to £30,995 per annum depending on experience (Bioinformatician)
DEADLINE
27th July 2017, however applications will be considered and reviewed on an on-going basis and therefore the post may be filled before the deadline.
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