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    Opportunity: Bioinformatician/ Data Scientist @ Wellcome Trust Sanger Institute -- Hinxton/ Cambridgeshire, UK
    Submitted by Jennifer Chequer; posted on Friday, November 03, 2017


    COSMIC – the Catalogue Of Somatic Mutations In Cancer – is an expert-curated database describing the wide variety of genetic variations associated with all forms of human cancer. A key resource underpinning cancer genetic research, COSMIC provides large high-quality datasets, methods and graphics to scrutinise the genetics causing this disease, giving insights to pharmaceutical design and patient therapies. Built within the world-leading Sanger Institute (UK) to support global research, millions of mutations across thousands of diseases can be explored at

    The Wellcome Trust Sanger Institute operates at the forefront of genomics, sequencing and analyses targeting a wide range of genomes from single cell pathogens to higher vertebrates, with an emphasis on genomes relevant to human medicine and welfare. The Cancer Genome Project at the Institute has led the way in the systematic analysis of cancer genomes by using the human genome sequence and high throughput mutation detection techniques to identify somatically acquired sequence variants/mutations and hence identify genes critical in the development of human cancers (


    • We are looking for a talented and highly motivated data scientist/ bioinformatician to play a crucial role in new research on cancer mutations in the COSMIC team at the Sanger institute, Hinxton. In this study, we are aiming to characterise every genetic mutation in every form of cancer, to define - at high-resolution across global populations - the important events which are driving disease.
    • You will work together with COSMIC scientific team, bringing bioinformatic or data science expertise to a new project aiming to describe every cancer mutation across multiple biological properties. We aim to take a very broad approach across millions of variants and hundreds of cancer disease types, to identify which variants act as drivers of disease, then correlate how they work together to cause disease progression.
    • Working in the COSMIC team, the world's largest and most detailed database of cancer mutations will be available to you. Within the broader Sanger Institute, you will have access to global specialists in genomics with decades of experience discovering new disease genes, and who are already exploring these data. In addition, this information is vital for use in pharmaceutical and clinical applications, so we have partnered with AstraZeneca on this project, working closely with their Oncology division, and therefore your research will impact directly on the discovery and development of new precision medicines.
    • We anticipate this project will become a major new resource to discover new targets in cancer genetics, and our research will ultimately have an impact on the clinical treatment of cancer patients when they reach hospital. You will also have opportunities to learn more about precision medicine, and how pharmaceutical development works.


    Essential Skills:
    • MSc in Bioinformatic or Computer Science discipline
    • Highly self-motivated, able to work independently and organise own workload
    • Excellent communication and effective team-working skills
    • Data handling skills
    • Experience of developing software


    Ideal Skills:
    • Good communication and presentation skills
    • Experience of developing software for scientific research
    • Knowledge of human or cancer genetics




    The Institute is located near Cambridge, UK on the stunning Wellcome Genome Campus.


    Salary in the region of £37,000 plus excellent benefits


    For further information, job description and to apply:[...]32910


    7th December 2017


    Wellcome Trust Sanger Institute welcomes applications from all candidates irrespective of age, disability, gender, gender identity, sexual orientation, race, religion or belief, or marital or civil partnership status.

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