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    Opportunity: Bioinformatics Engineer -- NGS @ Highly talented team based in London, UK
    Submitted by Eugene Mc Daid; posted on Tuesday, November 14, 2017



    A great opportunity is available for a scientific software developer to join a highly talented team based in London who are integrating cutting-edge semiconductor technologies with novel biochemical techniques to develop a new NGS platform and associated molecular diagnostic applications.

    The position is within the NGS Platform development team and you will be responsible for all aspects of primary analysis of NGS data throughout the product development process.


    • Design, implementation of a high-throughput automated primary DNA sequencing signal analysis software (base calls, mapped reads, Phred scores, error rate, signal to noise, phasing, coverage depth)
    • Development of a user-friendly software tool suite for deeper analysis and troubleshooting of sequencing results including QC software
    • Analysis of data sets generated by ongoing R&D work including but not limited to modelling of raw electronic signals generated by the NGS platform
    • Cross-functional training on the use of the primary analysis tool suite and ongoing support of internal users
    • Continuous improvement of algorithms and software tools
    • Fulfilment of all documentation requirements


    • Development, optimisation and implementation/use of NGS primary analysis algorithms and software tool suites
    • Proficient in Python - SciPy, NumPy, Pandas (other scripting languages)
    • Excellent academic background in a relevant discipline with postgraduate level preferred
    • Confident in a Linux environment and source code repository Git
    • MS. or PhD preferred in scientific fields like Applied Mathematics, Chemistry, Physics, Biochemistry, Biomedical Engineering, Bioinformatics, Electrical Engineering or Computer Science
    • Understanding and demonstrable skills in real-time signal processing, data analysis, control theory, optimisation, pattern recognition and machine learning
    • Working knowledge of bioinformatics formats (FastQ, BAM, SAM, etc.)
    • Innovative problem-solving abilities, self-motivated and goal-oriented
    • Clear communication skills and proven ability to train others


    • Experience with ISFET-based sequencing and signal processing
    • Sound knowledge of genomics and statistical methods
    • Compiled programming languages C/C++, Matlab, R
    • Open source genomics tools such as SamTools, Isaac, BWA, BowTie2
    This is an ideal role for someone who is self-motivated, enjoys working in interdisciplinary teams and would thrive in a start-up environment.


    There are some great benefits available with this position including a competitive salary and the opportunity to work with some of the smartest minds in the industry.


    Please do not hesitate to contact Harvey Uppal at huppal[at] or call (+44) 121 616 3407 to discuss this opportunity further.

    Keywords: Software, Engineer, Developer, NGS, Bioinformatics, Genomics, Pipeline, DNA, QC, Next, Generation, Sequencing, Python, NumPy, SciPy, Pandas, Linux, FastQ, BAM, Statistics, London.

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