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    Opportunity: Bioinformatician: post-transcriptional genomics @ Memorial Sloan-Kettering Cancer Center -- New York City, NY (US)
    Submitted by Eric Lai; posted on Wednesday, January 31, 2018

    BACKGROUND

    We seek a motivated bioinformatician to be involved in our studies of gene regulatory networks. Our laboratory at Memorial Sloan-Kettering Cancer Center combines computational and experimental approaches to annotate and functionally elucidate small RNA pathways, mRNA processing and modification pathways, and transcription factor networks. Towards this end, we produce small RNA, RNA-seq, CLIP-seq, RNA modification and ChIP-seq data, and analyze these with respect to the rich comparative genomic data available for Drosophila and mammals. There is a close exchange of ideas between dry and wet lab members to generate and test biologically-based hypotheses.

    Recent Studies involving genomics/bioinformatics approaches:

    Kan, L., A. V. Grozhik, J. Vedanayagam, D. P. Patil, N. Pang, K.-S. Lim, Y.-C. Huang, B. Joseph, C.-J. Lin, V. Despic, J. Guo, D. Yan, S. Kondo, W.-M. Deng, P. C. Dedon, S. R. Jaffrey and E. C. Lai (2017). The m6A pathway facilitates sex determination in Drosophila. Nature Communications 8: 15737, 1-16.

    Kondo S., J. Vedanayagam, J. Mohammed, S. Eizadshenass, L. Kan, N. Pang, R. Aradhya, A. Siepel, J. Steinhauer and E. C. Lai (2017). New genes often acquire male-specific functions but rarely become essential in Drosophila. Genes and Development 31: 1841--1846. (Highlighted in Genes and Dev 31: 1825-1826.)

    Sanfilippo P., J. Wen and E. C. Lai (2017). Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species. Genome Biology 18: 229 doi: 10.1186/s13059-017-1358-0.

    Mohammed, J., A. S. Flynt, A. M. Panzarino, M. Mondal, M. DeCruz, A. Siepel and E. C. Lai (2018). Deep experimental profiling of microRNA diversity, deployment, and evolution across the Drosophila genus. Genome Research 28: 52-65.

    Jee, D., J.-S. Yang, S. M. Park, D.'J. Farmer, J. Wen, T. Chou, A. Chow, M. T. McManus, M. G. Kharas and E. C. Lai (2018). Dual strategies for Argonaute2 Slicer-dependent miRNA biogenesis of erythroid miRNAs underlie conserved requirements for slicing in mammals. Molecular Cell 69: 265-278.

    Lab home: www.sloankettering.edu/rese[...]c-lai

    RESPONSIBILITIES

    The candidate will integrate into several related projects regarding post-transcriptional regulation, including mechanisms of miRNA biogenesis, tissue-specific alternative polyadenylation, and in vivo regulation by m6A/RNA methylation.

    REQUIREMENTS

    Relevant candidates will have strong computational skills and experience with analyzing deep-sequencing data, comparative genomics and statistics. In addition to utilizing standard NGS packages, programming proficiency is required to develop custom scripts for novel sequence analyses as well as to develop web-basted data displays. The successful candidate will be self-motivated and highly interactive to work with biologists to solve foundational questions in genome regulation. Postdoctoral fellows or BA/MS level candidates seeking experience before graduate school will be considered.

    LOCALE

    Memorial Sloan-Kettering Cancer Center, New York City

    HOW TO APPLY

    Please send letter of inquiry, research statement, CV and references to laie[at]mskcc.org.

    DEADLINE

    As soon as possible.

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