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Education: FEBS 2018 Advanced Course -- The molecular basis of diseases: Can we infer phenotypes from protein variant analysis?
Submitted by Pier Luigi Martelli; posted on Wednesday, February 21, 2018
May 23-25, 2018
Bologna, Italy
https://genomeanalysis2018.febsevents.org
The workshop intends to present the state-of-the-art of the computational tools for interpreting at the molecular level the effects that genome variations induce in the cell system, contributing to fill the knowledge gap between genotype and phenotype.
NGS techniques allow detection of the differences in genetic sequences and in gene expression that can be associated to different phenotypes, and statistical methods can estimate a significance level for each association. However, the exploitation of genetic association data requires elucidation of how variations affect the structure of macromolecules and their interaction patterns and how biological processes and pathways are hampered. Proteins, their stability and their relationships in interactomes will be the central topic. Furthermore, a particular regard will be given to the regulation at the transcriptional and translational levels, as derived from epigenomic and ribosome profiling data.
Computational tools are absolutely necessary to perform the analysis of massive amounts of biomedical data and modern techniques for database integration, non parametric statistics, machine-learning and in particular deep-learning approaches, can have a huge impact in the field. The exploitation of data in the applicative domains, and in particular in translational and stratified medicine, strongly rely on the availability of computational methods able to extract, elaborate and generalise biologically relevant information
The workshop aims at presenting the state-of-the-art of computational methods for genome interpretation and collects expert scientists from both experimental biomedicine and computational biology. The mixing of competences is fundamental for generating significant advancements, and the proposed workshop .
The format of the workshop allows extensive interaction among students and lecturers, and offers to young researchers the possibility of presenting their work at poster sessions and with short selected talks.
IMPORTANT DATES
Application deadline: April 15, 2018
Deadline for applying to FEBS Youth Travel Funds (YTF): February 28, 2018
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