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    Opportunity: Bioinformatician/Computational Biologist position in Genetics and Functional Genomics of Complex Disease @ Mass Eye and Ear, Harvard Medical School -- Boston, MA (US)
    Submitted by Ayellet Segre; posted on Friday, April 06, 2018


    The Segrè lab at the Ocular Genomic Institute and Department of Ophthalmology at Massachusetts Eye and Ear Infirmary (MEEI) and Harvard Medical School is seeking a Bioinformaticist or Computational Biologist with a strong background in computer science, biostatistics, bioinformatics or a related quantitative field, interested in contributing to uncovering the genetic and biological causes of common eye diseases, paving the way for new preventative and therapeutic treatments. In the Segrè lab we develop and apply new computational and statistical methods that integrate large-scale human genetic association studies of complex eye diseases, such as age-related macular degeneration, glaucoma and diabetic retinopathy, with functional genomics and RNA-sequencing data from relevant tissues to detect regulatory mechanisms that lead to vision loss. To learn more about the lab please visit:


    The successful candidate will develop and run computational pipelines for QC'ing and analyzing genome-wide association and sequencing studies and various -omics data, e.g. expression quantitative trait loci (eQTLs), epigenetic and RNA-sequencing data, using existing and custom-built tools. The candidate will perform statistical and computational analyses for research projects focused on identifying genetic risk factors and causal genes and pathways of common eye diseases. The candidate will both support ongoing projects in the lab and work on independent projects, while critically reviewing and communicating results to our team and collaborators, and will contribute to publications. The candidate will work amongst other computational biologists and computer scientists in the Bioinformatics Center of the Ocular Genomics Institute at Mass. Eye and Ear, and will be part of a larger multidisciplinary research environment of human geneticists, clinical scientists, and experimental and computational biologists at MEEI and the Broad Institute of Harvard and MIT.


    The position requires a B.Sc. in computer science, (bio)statistics, bioinformatics, mathematics, or a related quantitative discipline. M.Sc. or Ph.D. in these fields are preferred. The ideal candidate should have excellent programming skills and in-depth experience with multiple programming languages (e.g. Python, R and/or Matlab, and C++ and/or Java) and with Unix/Linux, and have demonstrated rigorous work. Experience with large-scale data analysis, algorithm development and statistics required; Research experience with DNA sequencing, RNA sequencing and/or epigenetic data preferred. The candidate should have strong personal skills and excellent verbal and written communication and organizational skills. The applicant should be highly motivated to work in a fast-paced and rapidly evolving field and collaborative environment, and be passionate about using genomics to advance the understanding and treatment of eye diseases.


    Ocular Genomics Institute, Massachusetts Eye and Ear, Boston, MA / Harvard Medical School / Broad Institute of Harvard and MIT


    A competitive salary will be provided commensurate with experience, along with health and other benefits.


    Interested applicants should send their CV, a cover letter describing previous research experience and future research interests, and contact information for 3 references, to Dr. Ayellet Segrè: ayellet_segre [at]


    Applications will be reviewed until position is filled.

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