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    Opportunity: Senior Bioinformatician -- Division of Genetics @ Brigham and Women's Hospital -- Boston, MA (US)
    Submitted by Soumya Raychaudhuri; posted on Wednesday, May 02, 2018


    The bioinformatician will play a central role in the management and analysis of single cell genomic data at the new Chromium 10X core facility at Brigham and Women's Hospital. The core facility will run cutting edge experiments on single cell data, including but not limited to single cell RNA-seq, antibody oligo tagging for protein quantification, TCR and BCR sequencing for repertoire analysis, and multiplexed droplet experiments. The bioinformatician will have the opportunity to contribute scientifically to the implementation and testing novel algorithms, the development of specialized software and high throughput analysis pipelines, and the collaborative analysis of genomic and clinical data with senior scientists from Brigham and Women's Hospital, Harvard Medical School, The Broad Institute, and the Dana Farber Cancer Institute. The bioinformatician will work closely with Dr. Soumya Raychaudhuri, senior scientists from the Harvard Medical School immunogenomics lab, as well as with outside collaborators. The bioinformatician will have access to computational resources from Partners Healthcare and the Broad Institute. Much of this role is flexible and can suit the talents and interests of capable scientists and engineers.


    • Manage the storage, access, and dissemination of large amounts of data.
    • Develop robust computational pipelines for automated processing of single cell genomic data.
    • Implement and test novel algorithms from scientific literature.
    • Documentation of computational procedures and analyses for reproducible research.
    • Regularly communicate with lab members, collaborators, and technical staff from related core facilities.
    • In collaboration with senior scientific staff, initiate and foster scientific collaborations outside the lab.
    • All other duties as assigned.


    • Education: MSc or PhD degree in appropriate technical, scientific, or engineering discipline (preferably bioinformatics, computational genomics, or computer science) and at least 2-years experience in a data science driven field
    • Strong programming skills capable of conceiving, of implementing and optimizing programs operating on large data sets
    • Strong written and oral communication skills
    • Unix environment experience; experience with large data sets, database software experience
    • Proficiency in a programming language, such as Java, C/C++, or python and one or more mathematical languages, such as R or MATLAB


    • Experience with bioinformatics and transcriptomic analysis, particularly with single cell RNA-seq data
    • Experience working in an interdisciplinary environment and communicating technical ideas to a wide audience
    • Experience in machine learning and statistical modeling
    • Experience with software engineering and numerical programming
    • Advanced knowledge of biostatistics and statistical programming
    • Formal knowledge in Biology in general; genetics in particular


    Full Time Position


    Primary Location: MA-Boston-BWH Longwood Medical Area


    Commensurate with experience


    Please send CV and cover letter to Project Manager, Dennis Guevara (dguevara[at]


    EEO Statement:
    Brigham and Women's Hospital is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, national origin, sexual orientation, protected veteran status, or on the basis of disability.

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