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    Opportunity: Research Fellow -- Cancer genetics and genomics (#59355) @ University of Birmingham -- Birmingham, UK
    Submitted by University of Birmingham; posted on Friday, June 15, 2018


    We are looking for a highly motivated bioinformatician/research fellow to join the Gastrointestinal Cancer Genetics group, led by Dr. Claire Palles ([...].aspx).


    This two year position is funded by a project grant from Bowel Cancer UK[...]ects/. The overall aims are to identify the genetic causes of colorectal cancer (CRC) in the under-50s, determine the molecular features of cancers in these patients compared with older patients and stratify patients based on these data to further disease gene discovery and targeted therapy.

    The appointee will primarily be required to analyse data already generated on young patients recruited to a UK research study called CORGI (the identification and characterisation of inherited predispositions to colorectal tumours study) or recruited to studies led by our collaborators. Our dataset represents the largest collection of whole genome sequences from CRC cases diagnosed under age of 50. There will also be the opportunity to perform wet lab experiments limited to DNA extraction from tumour blocks and generation of somatic mutation and DNA methylation data using tumours from patients where we have sequenced the germline. We will compare tumour data to data from the MRC Stratification in Colorectal Cancer project (S-CORT).

    Applicants with bioinformatics experience should include a CV (including full publication list), a cover letter (including research interests and aspirations) and the contact information for two referees.

    The position is financed for 2 years.


    Essential qualifications:
    • 2:1 or equivalent science based bachelors with honours degree
    • PhD in a human genetics, cancer biology or other relevant topic
    • Publication in scientific journals, including at least one first or joint first author publication
    Essential experience:
    • Understanding of and experience of basic molecular biology techniques
    • Demonstrable understanding of genetics and aspects of cancer biology
    • Demonstrable ability of being up to date with latest methods and key field advances
    • Contributions to scientific papers and reports
    • Planning research and working effectively to meet deadlines
    • Good oral and written communication and presentation skills
    • Experience in Unix based analysis
    • Knowledge of genetic public datasets
    • Commitment to high standards, including record keeping and laboratory management
    • Ability to work with a high degree of independence, to learn rapidly and to master diverse molecular biology techniques and analysis methods


    Full Time, Fixed Term until July 2020


    University of Birmingham, Birmingham, UK
    College of Medicine and Dental Sciences
    Institute of Cancer and Genomic Sciences


    Starting salary is normally in the range Full time starting salary is normally in the range £29,799 to £38,832. With potential progression once in post to £41,212 a year.


    Please visit[...]xNw==


    13 July 2018


    To download the details of this position and submit an electronic application online please click on the Apply Online button below, please quote the appropriate Job Ref in all enquiries, alternatively information can be obtained from

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