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BACKGROUND

About TGen:
Translational Genomics Research Institute (TGen) is a Phoenix, Arizona-based non-profit organization dedicated to conducting groundbreaking research with life changing results. TGen is focused on helping patients with neurological disorders, cancer, and diabetes, through cutting edge translational research (the process of rapidly moving research towards patient benefit). TGen physicians and scientists work to unravel the genetic components of both common and rare complex diseases in adults and children. Working with collaborators in the scientific and medical communities literally worldwide, TGen makes a substantial contribution to help our patients through efficiency and effectiveness of the translational process. TGen is allied with City of Hope, a world-renowned independent research and cancer and diabetes treatment center. This precision medicine alliance enables both institutes to complement each other in research and patient care, with City of Hope providing a significant clinical setting to advance scientific discoveries made by TGen. For more information, visit: http://www.tgen.org.

Dr. Nicholas Schork, Director of Quantitative Medicine at TGen, seeks a creative, independent, and highly motivated researcher interested in developing and applying novel and comprehensive annotation methods for genes and genetic variants in a wide variety of contexts, in particular disease diagnosis, therapeutic choice and cross-species (orthology) disease model analyses. The methods to be developed will consider modeling the influence of genetic variants on gene function and the functional effects of genes that can be reconciled across species.

RESPONSIBILITIES

The post-doctoral fellow will have the opportunity to develop and evaluate computationally-based gene and genetic variant functional models in a collaborative environment that includes basic scientists, computational and quantitative scientists, biomedical technology developers, evolutionary biologists and clinicians, including those at TGen's affiliated institution, the City of Hope Hospital in East Los Angeles, as well as its many other partner institutions.

Variant functional annotation and orthology assessment methods are being developed rapidly. In addition, databases harboring information about the likely influence of genes and genetic variants in pathway and network contexts exist and continually being refined (e.g., the GTEX databases). Finally, large-scale functional studies using emerging model systems and in vitro assays such as CRISPR screens are being pursued to generate information that needs to be mined and reconciled. The challenge will be to integrate all of this into more comprehensive models of gene function and leverage them to make claims about the health status of individuals, the likely benefits of specific gene-targeting therapeutics, and the utility of specific model systems to understand disease pathogenesis. In this context, the proposed activity and research will involve:

Modeling and the influence of genetic variants on gene expression, protein structure and function, splicing, and other molecular physiologic processes
Considering the combined influence of multiple genetic variants on gene function
Developing models that consider compensatory and feedback mechanisms in networks and biological processes
Developing methods that leverage sequence orthology and homology across different species to assess function
Contributing to the development of software and webtools that implement the models to be developed
Participating in the implementation and evaluation of the application of the models to be developed
Present the models at major conferences and in peer-reviewed publications

TGen has access to some of the largest and fastest computing systems in the world that can be leveraged in the proposed research. In addition, the development of the proposed models will likely have a broad, international impact, given the amount of attention genetics and genomics research is receiving, so the research to be pursued will be highly visible and competitive, and as a result could propel the career of an independently-minded researcher looking to make an indelible impact on a biomedical science.

REQUIREMENTS

Ph.D. (completed or near completion) in Bioinformatics, Systems Biology, Computational or Quantitative Biology, Biostatistics, Comparative Biology, or a related field.
Computer programming, R, scripting languages, and biological database query skills
Familiarity with genomics and comparative biology
Experience with large biological data sets
Excellent written and verbal communication skills
Willingness to work in collaborative settings
No publication record is required, but a publication track record is preferred

HOW TO APPLY

If you are interested in seeing the most up to date job listings or to apply for this position, please go to https://www.tgen.org/careers-tgen/#.WdP3F39e6Uk and submit your resume to IRC13068. Please take a moment to read about our employee benefits and learn more about TGen. If you have any questions about the company or how to apply for a position, please contact hr[at]tgen.org.

Only resumes submitted through the TGen career website will be considered.

Discussion forums: Opportunity: Postdoctoral Fellow in Bioinformatics and Systems Biology @ The Translational Genomics Research Institute -- Phoenix, AZ (US)

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