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Opportunity: Postdoctoral Fellow in Human Genetics and Functional Genomics of Complex Eye Diseases @ Mass. Eye and Ear, Harvard Medical School -- Boston, MA (US)
Submitted by Ayellet Segre; posted on Thursday, September 20, 2018
BACKGROUND
The Segrè lab in the Ocular Genomic Institute and Department of Ophthalmology at Massachusetts Eye and Ear Infirmary (MEEI) and Harvard Medical School is seeking a highly motivated and creative Postdoctoral Fellow who is interested in working on integrative human genetics, genomics, and systems biology problems, and developing novel computational methods that will generate important biological insights on the causes of complex eye diseases. The ideal candidate should have a strong background in statistical genetics, biostatistics, computational genomics, or a related quantitative field, and be broadly knowledgeable about quantitative approaches to large-scale data analysis and excited to contribute to advancing science and medicine of eye disease.
The overall goal of the lab is to uncover the regulatory mechanisms and causal genes and pathways that affect common eye disease susceptibility, such as glaucoma, age-related macular degeneration, and diabetic retinopathy, and to propose new drug targets and drug repurposing opportunities, leading to new preventative or therapeutic treatments. We will build upon our expertise of developing statistical methods that integrate genome-wide association studies of complex diseases with functional genomics from relevant tissues and other -omics and biological data. This position will be under the supervision of Dr. Ayellet Segrè, an Assistant Professor in Ophthalmology, Harvard Medical School, Genetic Biostatistician at Mass. Eye and Ear, and Associate Member at the Broad Institute of MIT and Harvard. To learn more about the lab please visit: https://segrelab.meei.harvard.edu.
RESPONSIBILITIES
The postdoctoral fellow will work on his or her own research project, in line with the goals of the lab. Possible directions may include developing statistical and computational methods for integrative analysis of genome-wide association studies with expression quantitative trait loci (eQTLs), splicing QTLs, and epigenomic data from retina and other eye tissues to identify genetic risk factors and causal genes for complex eye diseases; analysis of large-scale genetic association studies across multiple complex traits and diseases to identify new drug repurposing opportunities for common eye diseases and predict adverse drug effects; rare variant analysis of coding and regulatory regions to identify causal mechanisms of eye disease. There will be opportunities to follow-up hypotheses in relevant biological systems, and to present ones work at local, national or international meetings. The postdoctoral fellow will work in a multidisciplinary research environment of computational biologists, human geneticists, and experimental and clinical scientists at the Ocular Genomics Institute at Mass. Eye and Ear and will be able to interact with the vibrant scientific community at the Broad Institute of Harvard and MIT.
REQUIREMENTS
Requirements include a Ph.D. in Statistical Genetics, Human Genetics, Biostatistics, Functional Genomics, Computational Biology, or a related quantitative discipline. The ideal postdoctoral candidate should have strong quantitative skills, solid knowledge in statistics, in-depth experience with at least one programming language (e.g., Python, R or Matlab), be proficient in Bash or Shell scripting and Unix/Linux environments, and have demonstrated rigorous work, and independent and critical thinking. Previous experience with large-scale data analysis and algorithm development is highly desirable; Research experience with genome-wide association studies, whole genome sequencing, epigenetic and/or RNA-seq data preferred. The candidate should have a good publication record in peer-reviewed journals, strong personal skills, and excellent verbal and written communication and organizational skills. The applicant should be highly motivated to work in a fast-paced and rapidly evolving field and collaborative environment, excited about contributing new ideas to the group, and be passionate about using genomics to advance the understanding and treatment of eye diseases.
LOCALE
Ocular Genomics Institute, Massachusetts Eye and Ear, Boston, MA / Harvard Medical School / Broad Institute of Harvard and MIT
COMPENSATION
A competitive salary will be provided, along with health and other benefits.
HOW TO APPLY
Interested applicants should send their CV, a cover letter describing previous research work and future research interests, and contact information for 3 references, to Dr. Ayellet Segrè: ayellet_segre[at]meei.harvard.edu.
DEADLINE
Applications will be reviewed until position is filled.
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