OVERVIEW

RESPONSIBILITIES

• Oversee the continued development of all institutional NGS cancer sequencing efforts, including targeted capture assays, RNA-seq, whole exome, whole genome and cfDNA.
• Oversee the necessary validation, and QC associated with each of our NGS assays.
• Oversee new bioinformatics analyses, including tumor mutational load analysis, viral signature detection, and improved methods for detecting structural rearrangements.
• Recruit and manage a team of computational biologists, focused on NGS bioinformatics.
• Interface with the Bioinformatics Platform Group, which will be developing a new scalable, cloud-based platform for running all NGS sequencing pipelines.
• Interface with Clinical Genomics and Data Sharing Teams at DFCI, to ensure that results of NGS sequencing have maximal clinical and research impact.
• Interface with faculty within the Department of Data Sciences to ensure the rapid adoption and integration of new NGS analysis algorithms.

REQUIREMENTS

• PhD (or equivalent) in computational biology, bioinformatics, or related fields
• 10+ years of NGS bioinformatics experience in an academic or industry setting
• Proven experience in building NGS methods and pipelines at an academic sequencing center or industry
• Publication record in NGS and cancer genomics
• Proven experience in leveraging best practices from the genomics community, e.g. GATK, Mutect, etc.
• Proven experience in managing a team of computational biologists
• Excellent interpersonal communication and writing skills
• Excellent organization skills, including the ability to organize teams
• Exceptional attention to detail
• Strong leadership skills

HOW TO APPLY

POLICY