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RESPONSIBILITIES

Applications are invited for a Senior Bioinformatician in the Genomics of Inflammation and Immunity Group at the Wellcome Sanger Institute, led by Dr. Carl Anderson (http://www.andersonlab.info).

You will play a central role in a substantial research programme aiming to use high-throughput genetics and genomics to further our biological understanding of immune-mediated diseases and, ultimately, identify new drug targets. To help us achieve this mission, we are currently generating whole-genome/exome sequencing data on tens of thousands of patients from the UK with inflammatory bowel disease (IBD) or primary sclerosing cholangitis (PSC). We are coupling this effort with the generation of single-cell RNA/ATAC sequencing of disease relevant tissues from a subset of these patients and healthy controls. Finally, we are combining results from these experiments (and others) with our detailed clinical phenotype data to identify causal biology underpinning disease susceptibility and progression.

You will be responsible for developing and maintaining many of the computational pipelines that underpin the team's research. These include, but are not limited to, pipelines for single-cell RNA/ATAC-seq analysis, molecular QTL mapping, whole-genome/exome based association studies and causal variant fine-mapping. In addition, you will be responsible for further developing PhenoDB, our in-house database of phenotypic data from more than 15,000 inflammatory bowel disease patients.

You will join a multi-disciplinary team of statisticians, geneticists, immunologists, computer scientists and clinicians who work together to understand the genetics and genomics of immune-mediated disease. You will have a collaborative approach to research and take a full and active role in discussions, contributing both ideas and expertise as necessary.

REQUIREMENTS

Essential Skills:

Ability to work with others in a friendly and collegiate environment
A degree (PhD, MSc or BSc with equivalent experience) in a quantitative field (e.g. Bioinformatics, Computer Science, Computational biology or similar quantitative discipline)
Demonstrable shell scripting skills (e.g. bash, tcsh, awk, sed)
Proficient Python programmer, including experience of using web development frameworks (e.g. Django, Flask)
Demonstrable experience of the design and use of relational SQL databases
Demonstrable experience of developing practical computational tools for data parsing, quality control, modelling and analysis of large-scale genetic or genomics datasets (e.g. 1000s of individuals with sequencing/GWAS data)
A passion for problem solving and creative thinking
A self-motivated and independent working style with good organisational skills and an attention to detail
A good communicator with an interest in using your skills to help others

PREFERENCES

Ideal Skills:

Experience of javascript libraries (e.g. jQuery, D3)
Experience of Unix server configuration (e.g. Nginx)
Experience of OpenStack, AWS, Google Cloud, Azure or other cloud computing environments
An interest in using genetics and genomics to identify drug targets for immune-mediated diseases such as inflammatory bowel disease

TERMS

Permanent

LOCALE

Human Genetics Anderson Faculty

COMPENSATION

Salary range from: £36,737 to £44,451 pa dependent on experience

Our Benefits: Our employees have access to a comprehensive range of benefits and facilities including:

Group Defined Contribution Pension Scheme and Life Assurance
Group Income Protection
Private Health Insurance
25 days annual leave, increasing by one day a year to a maximum of 30
Family friendly environment including options for flexible and part-time working, a childcare voucher scheme, Campus Nursery and Summer holiday club
Two days paid Employee Volunteering Leave a year
Employee Discount Scheme
Campus Gym, tennis courts, cricket pitch and sports hall plus a range of dining facilities
Active Campus Sports and Social Club
Free Campus Bus Service

ABOUT US

The Wellcome Sanger Institute is a charitably funded research centre and committed to training the next generation of genome scientists. Focused on understanding the role of genetics in health and disease and a world leader in the genomic revolution, our mission is to use genome sequences to advance understanding of human and pathogen biology in order to improve human health. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens. Our science is large-scale and organised into Programmes, led by our Faculty who conceive and deliver our science, and supported by our Scientific Operations teams responsible for all data production pipelines at the Institute. Our Campus: Set over 125 acres, the stunning and dynamic Wellcome Genome Campus is the biggest aggregate concentration of people in the world working on the common theme of Genomes and BioData. It brings together a diverse and exceptional scientific community, committed to delivering life-changing science with the reach, scale and imagination to pursue some of humanity's greatest challenges.

HOW TO APPLY

Please visit http://www.jobs.sanger.ac.uk.

Please include a covering letter and CV with your application.

DEADLINE

Closing date: 15 March 2019 however the role will remain open until filled with applications considered on an on-going basis.

POLICY

Genome Research Limited is an Equal Opportunity employer. We will consider all applicants without discrimination and are committed to creating an inclusive environment for all employees.

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