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Opportunity: Bioinformatician position: post-transcriptional regulatory networks, Lai lab @ Memorial Sloan-Kettering Cancer Center -- New York City, NY (US)
Submitted by Eric Lai; posted on Tuesday, March 12, 2019
BACKGROUND
We seek a motivated bioinformatician to be involved in our studies of post-transcriptional regulatory networks. Our laboratory at Memorial Sloan-Kettering Cancer Center combines computational and experimental approaches to discover, annotate and functionally elucidate diverse post-transcriptional regulatory pathways and their biological impacts. Currently, we are particularly interested in non-canonical small RNA pathways, alternative mRNA processing strategies, and RNA methylation. Towards these ends, we produce RNA-seq, 3'-seq, CLIP-seq, small RNA, RNA modification and ChIP-seq data, and analyze these with respect to the rich comparative genomic data available for Drosophila and mammals. https://www.mskcc.org/research/ski/labs/eric-lai
Recent Studies involving genomics/bioinformatics approaches:
Kan, L., A. V. Grozhik, J. Vedanayagam, D. P. Patil, N. Pang, K.-S. Lim, Y.-C. Huang, B. Joseph, C.-J. Lin, V. Despic, J. Guo, D. Yan, S. Kondo, W.-M. Deng, P. C. Dedon, S. R. Jaffrey and E. C. Lai (2017). The m6A pathway facilitates sex determination in Drosophila. Nature Communications 8: 15737, 1-16.
Kondo S., J. Vedanayagam, J. Mohammed, S. Eizadshenass, L. Kan, N. Pang, R. Aradhya, A. Siepel, J. Steinhauer and E. C. Lai (2017). New genes often acquire male-specific functions but rarely become essential in Drosophila. Genes and Development 31: 1841--1846. (Highlighted in Genes and Dev 31: 1825-1826.)
Sanfilippo P., J. Wen and E. C. Lai (2017). Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species. Genome Biology 18: 229 doi: 10.1186/s13059-017-1358-0.
Mohammed, J., A. S. Flynt, A. M. Panzarino, M. Mondal, M. DeCruz, A. Siepel and E. C. Lai (2018). Deep experimental profiling of microRNA diversity, deployment, and evolution across the Drosophila genus. Genome Research 28: 52-65.
Jee, D., J.-S. Yang, S. M. Park, D.J. Farmer, J. Wen, T. Chou, A. Chow, M. T. McManus, M. G. Kharas and E. C. Lai (2018). Dual strategies for Argonaute2 Slicer-dependent miRNA biogenesis of erythroid miRNAs underlie conserved requirements for slicing in mammals. Molecular Cell 69: 265-278.
Lin C.-J., F. Hu, R. Dubruille, J. Vedanayagam, J. Wen, P. Smibert, B. Loppin and E. C. Lai (2018). The hpRNA/RNAi pathway is essential to resolve intragenomic conflict to permit transmission of sons. Developmental Cell 46: 316-326. (Featured in Developmental Cell 46: 251-253).
RESPONSIBILITIES
The candidate will integrate into projects that seek the mechanistic bases and impact of (1) tissue-specific alternative polyadenylation, and (2) regulation and dysregulation of miRNA biogenesis. There is a close exchange of ideas between dry and wet lab members to generate and test biologically-based hypotheses.
REQUIREMENTS
Relevant candidates will have strong computational skills and have demonstrated extensive experienced with analyzing deep-sequencing data, comparative genomics and statistics. Fluency with at least one general purpose programming languate (e.g. Perl or Python), a language for statistical computing (e.g. R), proficiency with bash/shell scripting in LINUX/UNIX environments for using high performance clusters, and knowledge of HTML/JavaScript for building web-based data interfaces.
Excellent problem solving, independent thinking, communication skills and scientific curiosity are critical. Working knowledge (and desire to learn) how experimental datasets are generated, appreciation for biological variability, technical artifacts, and, experimental validation of computational conclusions, and teamwork between dry/wet lab are fundamental to the projects.
Minimum requirement of Master's degree with at least two years of relevant research genomics/NGS experience.
PREFERENCES
Postdoctoral fellows or BA/MS level candidates seeking experience before graduate school will be considered.
HOW TO APPLY
Please send motivation letter including details of prior research experience, CV, and contact information of three references to laie[at]mskcc.org.
DEADLINE
Position is available and applicants will be considered until filled.
POLICY
MSKCC is an Equal Employment Opportunity/Affirmative Action Employer.
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