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    Opportunity: Genetics Lead -- Perm or Contract @ A fast-moving global pharma company -- Belgium
    Submitted by Eugene McDaid; posted on Monday, February 10, 2020



    This is a very interesting role with a fast-moving global pharma company focused on the discovery and development of innovative medicines and solutions to transform the lives of people living with severe diseases.

    The genetics group within this company work globally across both the Drug Discovery and Clinical Development functions, with a focus on leveraging genetics to support target identification and validation as well as clinical development projects i.e. pharmacogenetics.


    The role will be responsible for forming the bridge between the Genetics group and the local Discovery and Clinical Development groups in Braine-l'Alleud, Belgium, leading efforts to ensure interpretation and extraction of maximal value from results. The ability to run analyses, such as PheWAS, on specific platforms will be required.

    The successful candidate will support the development and implementation of the Genetics strategy, with a focus on the pharmacogenetic component. By working with the Therapeutic Areas and Biomarker Leaders, the incumbent will provide expert leadership and support in ensuring that genetics is being systematically, but optimally applied across the drug development portfolio. The successful candidate will also lead efforts to ensure integration of genetics data with other data sets, using machine learning approaches, to ensure a holistic approach is used to extract maximal value from the data.

    This post holder will be a key member of a highly motivated and dynamic multidisciplinary project team consisting of geneticists and computational biologists. As part of the Data and Translational Sciences, and the Translational Medicine groups, the candidate will have access to, and work with, the required complementary functions including bioinformaticians, data scientists, biomarker experts and clinical development teams.

    Key accountabilities include:
    • To develop cross-functional relationships, ensuring all projects are informed and supported by genetic data
    • To lead and deliver projects for Therapeutic Areas and Early Clinical Development
    • To support development, implementation and integration of pharmacogenetics across the company, and work with Early Development teams and Biomarker Leaders
    • To generate, interpret and follow up on data
    • To work with the Genetics team to generate data to support projects, including running in silico analyses and coordinating wet lab work as required


    Key competencies include:
    • Direct experience of the application of genetics and genetic approaches to drug discovery and development
    • Direct experience of working within multidisciplinary projects teams within the Pharmaceutical sector
    • Direct experience of devising, implementing and leading genetics strategies to support clinical development programs i.e. pharmacogenetics. Experience with protocol/ICF development is a plus.
    • Direct experience of generating, analysing and using genetic data generated through multiple platforms, including next generation sequencing (NGS) and genome-wide association studies (GWAS). Direct experience of interpreting and contextualizing genetic data for non-geneticists.
    • Problem solving skills
    • Experience/understanding of approaches and methods in functional genomics
    • Experience/understanding of ML/AI approaches


    There are some great benefits on offer with this role including a competitive salary, strong pension, generous holidays and more.


    Please do not hesitate to contact Harvey Uppal at huppal[at] or call (+44) 121 616 3407 to discuss this opportunity further.

    Keywords: Genetics, Lead, Pharmacogenetics, Pharma, Drug, Discovery, Clinical, Proteomic, Belgium, Transcriptomic, Statistics, Machine, Learning, AI, Biomarkers, Bioinformatics, GWAS, PheWAS, NGS

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