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Opportunity: Research Technician I/II -- Bioinformatics (Peters Lab) @ La Jolla Institute for Immunology -- La Jolla, CA (US)
Submitted by Jenna Pasut; posted on Friday, November 13, 2020
BACKGROUND
The Peters Lab at the La Jolla Institute for Immunology (LJI) is looking for a Bioinformatics Research Technician to join our ongoing efforts in profiling immune system responses to M. tuberculosis and/or B. Pertussis following infection or vaccination. Qualified applicants will have multiple opportunities to collaborate with our interdisciplinary team of experimental and computational scientists working towards understanding, preventing and curing infectious diseases. This position will be remote with the aim of returning on-site when normal working conditions resume.
Background: TB
Almost 2 billion individuals are infected with Mycobacterium tuberculosis (Mtb) the causative agent of tuberculosis (TB). Despite the relative low lifetime risk of latently infected individuals developing active disease (~5-15%) it has been estimated that 80% of new cases of TB are due to reactivation of latent disease. To meet World Health Organization's (WHO) goals of TB eradication by 2035 the massive reservoir of TB infection must be addressed. Our long-term goal is to develop an efficient diagnostic test that can predict which individuals are likely to progress to active TB.
Background: Pertussis
In the mid-1990s, concerns over vaccine-related side effects prompted the widespread replacement of the whole-cell Pertussis (wP) vaccine in favor of a safer acellular Pertussis (aP) vaccine. Recent years witnessed a worldwide reemergence of Pertussis (whooping cough) despite widespread vaccination. Our approach is to compare individuals born before 1995 and vaccinated in infancy with wP, with individuals born in 1996 or later and vaccinated with aP in infancy, thus directly studying the population and age group in which the increased disease incidence is noted. Our long-term goal is to identify the cascade of immune events following Pertussis booster vaccination, and to identify correlates of long-lasting vaccine-induced immunity.
RESPONSIBILITIES
Under the supervision of Senior Bioinformaticians in the Peters Lab, the Bioinformatics Research Technician will assist in performing experimental data analyses on immune correlates of progressing to active TB, and immune system profiling in different types of Pertussis vaccinations. Datasets will include RNA-Seq, flow cytometry, mass cytometry, and single-cell analysis.
REQUIREMENTS
Candidates must have:
- B.A./B.S. or higher in bioinformatics; or computer science and biological science, chemistry, or biochemistry. Previous experience in immunology is a bonus.
- Theoretical knowledge of biology, immunology, cell biology or related field at the college "upper division" level; or equivalent knowledge and experience.
- Ability to create, run, and modify Python and/or R scripts (a programming assessment will be done as part of the screening process)
- Proven experience in accurate record keeping with ability to organize, analyze, and calculate data.
- Superior oral and written communication skills.
- Positive attitude and ability to work as part of a team.
- Enthusiasm for learning new things.
- Ideal candidates should be able to commit >1 year to the position.
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