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    Opportunity: Bioinformatics Research Scientist -- Mefford Lab @ St. Jude Children's Research Hospital -- Memphis, TN (US)
    Submitted by John Stukenborg; posted on Thursday, January 07, 2021



    The Mefford Lab in the Center for Pediatric Neurological Disease Research uses genome-wide approaches to identify genetic, genomic and epigenetic causes of human disease including epilepsy, and related pediatric neurodevelopmental disorders. The major focus of our current work is to identify causes of pediatric epilepsy by employing state-of-the-art technologies including whole exome sequencing, targeted gene panel sequencing and custom array comparative genomic hybridization (aCGH). The Mefford lab has discovered numerous new epilepsy genes and copy number variants, including deletions of chromosomes 1q21, 15q13 and 17q12, each of which cause a range of clinical features.

    The Bioinformatics Research Scientist will take a prominent role in our research and collaborations to analyze multiple types of genomics data: exome and genome sequence, bulk RNA-seq, single cell/nuclei RNA-seq, methylation, SNP array, and others to identify variants associated with human genetic conditions and understand their underlying mechanisms. The ideal candidate will be capable of self-directed research within broader goals set by group, have previous experience with next-generation sequence data analysis highly desirable, knowledge of statistical/mathematical packages such as R.


    • Perform analysis and visualization of next-generation sequencing data.
    • Evaluate and integrate community-developed bioinformatics tools.
    • Research, develop and evaluate novel high performance computational approaches for next-generation sequencing analysis.
    • Work under general supervision on a wide range of projects and may be asked to guide the work of peers, technicians, students and/or other support staff as necessary to achieve specific assignments.
    • Compile, organize and summarize data for other members of the laboratory. If desired, the employee may have the opportunity to take primary responsibility for sub-projects in their area of expertise.
    • Participate and present at group meetings.
    • Assist with presentations and manuscripts.


    • Ph.D. in Molecular Biology, Biochemistry, Computer Science, Statistics, Mathematics, Bioinformatics or related field required.
    • Ph.D which must include research related to bioinformatics (such as analysis of sequence data, microarrays, SNPs, image data, proteomics data, or biological pathways; development of algorithms, statistical methods, or scientific software); OR If Ph.D with no bioinformatics research, then two (2) years of pre-or postdoctoral experience in Computational Biology or Bioinformatics research is required.
    • Experience with programming languages such as Perl, C, or Java required.


    Memphis, TN


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