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    Research: Medical Xpress: New statistical method exponentially increases ability to discover genetic insights
    Submitted by J.W. Bizzaro; posted on Friday, January 08, 2021

    Submitter

    EXCERPT

    Pleiotropy analysis, which provides insight on how individual genes result in multiple characteristics, has become increasingly valuable as medicine continues to lean into mining genetics to inform disease treatments. Privacy stipulations, though, make it difficult to perform comprehensive pleiotropy analysis because individual patient data often can't be easily and regularly shared between sites. However, a statistical method called Sum-Share, developed at Penn Medicine, can pull summary information from many different sites to generate significant insights. In a test of the method, published in Nature Communications, Sum-Share's developers were able to detect more than 1,700 DNA-level variations that could be associated with five different cardiovascular conditions.
    Source: medicalxpress.com/news[...].html
    Article: doi.org/10.1[...]211-2

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