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    Opportunity: Bioinformatics Research Scientist Pharmacogenomics @ St. Jude Children's Research Hospital -- Memphis, TN (US)
    Submitted by John Stukenborg; posted on Wednesday, April 07, 2021

    Submitter

    BACKGROUND

    A bioinformatics research scientist position is available in the field of pharmacogenomics in the Savic laboratory. The primary research focus of the Savic laboratory involves studying the gene regulatory architecture of pediatric leukemia and genomic responses to antileukemic agents in order to define how the noncoding portion of the human genome impacts chemotherapeutic drug response, chemotherapeutic drug resistance and leukemia relapse. To address these critical questions, the Savic laboratory uses functional genomics (ChIP-seq, ATAC-seq, RNA-seq, Hi-C, etc.) to map cis-regulatory elements and noncoding sequence variants in primary leukemia cells from patients and further applies high-throughput approaches (STARR-seq, MPRA, CRISPR screening, etc.) to functionally characterize their impact on gene regulation and pharmacological phenotypes using both in vitro and ex vivo models. The long-term goal of the Savic laboratory is to gain a better understanding of the genetic underpinnings of chemotherapeutic drug resistance and relapse in pediatric leukemia.

    RESPONSIBILITIES

    The successful candidate will be responsible for analyzing and integrating orthogonal genomic datasets in order to infer the pharmacogenomic impact of cis-regulatory elements and noncoding sequence variants. To meet these tasks, the candidate will be responsible for implementing, building and managing analytical pipelines for collaborative projects within the laboratory and beyond the laboratory.

    REQUIREMENTS

    Seven (7) years of relevant post-degree work experience is required.
    Five (5) years of relevant post-degree work experience is required with a Master's degree.
    Two (2) years of relevant post-degree work experience is required with a PhD.

    HOW TO APPLY

    Apply online: bs.serving-sys.com/Serv[...]95305

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