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    Software: Genozip: A universal compressor for genomic files
    Submitted by Divon Lan; posted on Tuesday, July 20, 2021

    Genozip is a universal compressor for genomic files – it is optimized to compress FASTQ, SAM/BAM/CRAM, VCF/BCF, FASTA, GVF, PHYLIP, Chain, Kraken and 23andMe files, but it can also compress any other file (including non-genomic files).

    Typically, a 2X-5X improvement over the existing compression is achieved when compressing already-compressed files like .fastq.gz .bam vcf.gz, and up to 200X for a high-sample-count VCF file.

    Yes, Genozip can compress already-compressed files (.gz .bz2 .xz .bam .cram).

    The compression is lossless – the decompressed file is 100% identical to the original file.

    Details: genozip.com. Available on conda (conda-forge channel) and github.com/divonlan/genozip

    Reference:
    Lan, D., et al. (2021) Genozip: a universal extensible genomic data compressor Bioinformatics, btab102, doi.org/10.1[...]ab102

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