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Opportunity: Postdoc in Yeast Synthetic Biology for Protein Engineering @ Novo Nordisk Foundation Center for Biosustainability -- Lyngby, Denmark
Submitted by Signatur AS; posted on Thursday, August 12, 2021
BACKGROUND
We are seeking a talented and driven postdoc to work on novel methods for high throughput protein engineering that leverages the power of multiplexed CRISPR genome engineering and yeast genetics. The candidate will join the Cell Architecture Group (PI Ryan T. Gill) at the Novo Nordisk Foundation Center for Biosustainability (CFB) in Denmark. The Cell Architecture Group is developing cellular engineering technologies based on high-throughput and multiplexed genome editing (CRISPR) for a wide range of downstream applications from industrial biotech to cell therapies.
The CFB is part of the Technical University of Denmark and provides a world-class research environment with state-of-the-art facilities and advanced technologies with special emphasis on cell factory engineering and systems biology technologies.
RESPONSIBILITIES
Responsibilities and qualifications:
The candidate will focus on developing synthetic biology technologies for protein engineering in yeast. We are looking for a candidate who has experience with protein engineering using microbial systems. The candidate will drive the research project forward by taking an active role in defining project goals, planning experiments, and analysing data. The project will leverage on previous technologies developed in our laboratory:
Moreover, the project will involve use of Inscripta's Onyx platform for automated, high-throughput genome engineering. The candidate will be responsible for executing laboratory projects involving a variety of approaches encompassing: yeast synthetic biology, DNA libraries design, high-throughput screens, and bioinformatics analyses.
Specific tasks include:
- Develop innovative research plans
- Design, implement and execute critical experiments associated with the research plan
- Document experimental design and results in electronic lab notebooks
- Analyse and organize data to draw meaningful conclusions
- Develop and support the submission of patents and other intellectual property
- Publish and present at professional meetings as appropriate
REQUIREMENTS
Candidates should have a PhD degree or equivalent in Biochemistry, Biotechnology, Bioengineering, Synthetic/Systems Biology or similar. Candidates with the background in Bioinformatics or Computational Biology and strong interest in working on experimental synthetic biology projects are welcome to apply.
- Excellence in independent problem solving
- Experience with microbial synthetic biology and protein engineering using library-selection methods
- Experience with next-generation sequencing is a plus
- Experience with omics data analysis and familiarity with scripting languages (e.g. Python, C++) for working with large data sets
- Enjoy sharing knowledge and experience with others
- Ability to lead multiple projects and support collaborations
TERMS & COMPENSATION
We offer:
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.
Salary and terms of employment:
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.
The initial period of employment is 1 year.
LOCATION
The place of employment is the DTU main campus in Kgs. Lyngby, Denmark.
DEADLINE
Please submit your online application no later than 15 September 2021 (Danish time).
ABOUT US
The Cell Architecture section works with developing technologies within genome engineering. The technologies span the entire iterative biotechnological cycle consisting of the steps: design, build, test and learn. The group aims at developing genome engineering technologies that address society's growing need for engineered cells, which spans a broad range of application areas including human health, sustainability, novel materials, the microbiome and the environment among others. The vision is to develop and disseminate such technologies in manners that result in rapid adoption and generate broad and significant impact.
The Novo Nordisk Foundation Center for Biosustainability (DTU Biosustain):
Recent progress in our ability to read and write genomic code, combined with advances in automation, analytics and data science, has fundamentally changed the scope and ambition of harnessing the potential of biological systems. Big data approaches and analysis of biological systems are key research instruments at the Center. DTU Biosustain utilizes these advances for microbial cell factory design to foster sustainable lifestyles in relation to three application areas: Sustainable Chemicals, Natural Products, and Microbial Foods.
Technology for people:
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN's 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 12,900 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.
POLICY
All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.
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