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  • News & Commentary - Message forums

    Resources: Predict protein structure from sequence easily, free!
    Submitted by Eric Martz; posted on Tuesday, October 26, 2021


    The AlphaFold project of DeepMind (Google) made a dramatic breakthrough in 2020. AlphaFold is often able to predict the structure of a protein from its sequence so well that the difference between the prediction and an X-ray crystallographic structure is as small as the difference between two independent X-ray determinations.

    Now, thanks to ColabFold, anyone can submit a sequence and get a free AlphaFold2 structure prediction. Its easy! Here are instructions:

    Reliability is estimated for each amino acid. FirstGlance in Jmol now automatically colors AlphaFold/ColabFold predictions by estimated reliability. Upload your predicted PDB file to

    Snapshot of Alphafold2 Colab prediction displayed in FirstGlance colored by estimated reliability per residue:

    Examples of AlphaFold2 Colab predictions ready to view instantly in FirstGlance:

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