A large UK study has shown that analyzing the entire genetic code of breast tumors can reveal important information about how the disease develops and how patients might respond to treatment. Researchers found that whole-genome sequencing can identify DNA changes linked to survival outcomes and uncover treatment options that standard genetic tests may miss. The findings suggest that using full-genome data could help doctors better match therapies to individual patients and avoid unnecessary treatments in the future.

ARTICLE

Turnbull, Clare, Helen Davies, Peter Van Loo, Serena Nik-Zainal, and colleagues. "Clinical Potential of Whole-Genome Data Linked to Mortality Statistics in Patients with Breast Cancer in the UK: A Retrospective Analysis." The Lancet Oncology (2025). https://doi.org/10.1016/S1470-2045(25)00400-0