[Next-Generation Sequencing Book]
  • [Photo] Sophie Gallina • October 22, 2003

    FIELD

    Microarray data and complex genetic disease analysis

    LOCALE

    INSTITUT DE BIOLOGIE DE LILLE
    CNRS UMR 8090 - Genetics of Multifactorial Diseases
    Lille - FRANCE

    BACKGROUND

    A full time POSITION in Biostatistics and Bioinformatics is available for 2 years starting November, 2003 in the Department of Human Genetics - Genetics of Multifactorial Diseases รข?? CNRS UMR 8090 - Director of Unit: Professor Philippe Froguel

    RESPONSIBILITIES

    Analysis of Affymetrix microarray data from transcriptome experiments using animal models and genetic data from human polymorphisms typed in both cohort and family studies. This will be carried out in the context of exploration of the molecular mechanisms underlying pancreatic beta-cell dysfunction and associated insulin-resistance.

    SPECIFIC ACTIVITIES

    1. Select and set up appropriate statistical methods for analyzing:
    • Microarray data, including normalization, selection of significant expression variation, clustering, GO annotation
    • Genetic data, including linkage analysis, association analysis, linkage disequilibrium mapping and haplotype construction
    2. Manage data (acquisition, validation, quality control, organization)
    3. Analyze data, interpret and present results
    4. Adapt or develop new statistical tools when necessary
    5. Optimize usage of such tools and set up standard analysis procedures
    6. Data acquisition from public databases and other online resources

    REQUIREMENTS

    Skills:
    • Knowledge of statistical methods
    • Experience of statistical software such as SPSS, S+ or R
    • Strong experience in microarray data analysis
    • Knowledge of public databases and other online biological resources
    Experience:
    Masters Degree (DESS) or PhD, and, ideally, practical experience of microarray experiments.

    CONDITIONS

    The Position is for 2 years, from the 1st of November 2003, in Lille, France, in the bioinformatics and biostatistics team (6 people) of the Genetics of Multifactorial Diseases Laboratory.
    Training in population genetics can be provided by the lab

    DEADLINE

    Applications will be reviewed in October 2003 until a suitable candidate is identified. Interviews may begin in late October.

    HOW TO APPLY

    Interested applicants should submit a letter of intent, a summary of previous research experience and a curriculum vitae, and reference to Sophie Gallina:
    Sophie.Gallina[at]mail-good.pasteur-lille.fr

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