[Next-Generation Sequencing Book]
  • [Photo] J.W. Bizzaro • February 8, 2006
    Christian Darkin sums up some of the accomplishments since the completion of the first draft of the human genome sequence five years ago, and considers what might come next:

    ``The growing menagerie of `model organisms' and what comparative analysis of them can achieve also impresses Robert Waterston, chairman of the genomic sciences department at the University of Washington. With the ability to knock down every gene in an organism like yeast, he says, a `true molecular description of yeast... is on the table.' Since yeast is a primary organism for comparisons with human sequences to discover genes and their controls, he adds, `I can't imagine it wouldn't have a profound impact on how you view humans.'
    [...]
    ``The long road of such incremental steps to clinical relevance creates impatience in genomics. Waterston says, `Yeah, there's frustration. I suspect among some quarters that read the hype and didn't know enough of the science, they would be frustrated. Anybody who knew the science knew that it was going to be a long time coming. These are hard problems. I would say that the progress that has been made on them is pretty substantial. But that's because I come in with a deep understanding of how hard it is.'''

    Full story:
    http://www.the-scientist.com/2006/2/1/42/1/

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