[Next-Generation Sequencing Book]
  • [Photo] J.W. Bizzaro • April 1, 2006
    The March issue of the journal Structure features an article on a 1 million atom-simulation of the complete tobacco mosaic virus:

    ``This work presents an all-atom molecular dynamics simulation of a complete virus, the satellite tobacco mosaic virus. Simulations with up to 1 million atoms for over 50 ns demonstrate the stability of the whole virion and of the RNA core alone, while the capsid without RNA exhibits a pronounced instability. Physical properties of the simulated virus particle including electrostatic potential, radial distribution of viral components, and patterns of correlated motion are analyzed and the implications for the assembly and infection mechanism of the virus are discussed.''

    More information is available on the research group's website:
    http://www.ks.uiuc.edu/Research/STMV/

    Print reference:
    Peter L. Freddolino, Anton S. Arkhipov, Steven B. Larson, Alexander McPherson, and Klaus Schulten. Molecular dynamics simulations of the complete satellite tobacco mosaic virus. Structure, 14:437-449, 2006.

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