INSTITUE BACKGOUND INFO

The Institute for Genomic Research (â??TIGRâ??) located in Rockville, MD, is a not-for-profit research center dedicated to deciphering and analyzing genomes.

DESCRIPTION

TIGR is seeking a Post Doctoral Fellow to join the Microbial Genomics department. The Post Doctoral Fellow will work on the functional analysis of the virulence of the biodefense pathogens Burkholderia mallei and Burkholderia pseudomallei and the adventitious pathogenic fungus Aspergillus fumigatus. The studies are genome scale analyses of the function and regulation of the complex gene regulatory systems and their relationship to virulence in mammalian hosts. They employ the traditional application of mutant construction including loss-of-function and inducible overexpression mutant constructs, phenotype screening, and microarray expression profiling. Virulence related phenotypes will be explored via the use of a mouse macrophage cell line, human macrophages, and small animal virulence testing. Host response to infection will be explored using microarray expression profiling of genes in the mouse and human genomes upon infection of human and mouse macrophages in culture.

REQUIREMENTS

M.D. or Ph.D. in relevant scientific discipline such as Molecular Biology, Biochemistry, Pharmacology, Immunology, Microbiology, Neuroscience or Computer Science required. Hands-on laboratory experience preferably in an independent project preferred. Supervisory experience preferred.

Demonstrated ability to effectively supervise staff.

High level of discretion for confidential work and information; ability to appropriately handle critical information and sensitive situations.

Ability to conduct investigations in relevant scientific areas.

Must be able to formulate experimental hypotheses and analyze and interpret scientific data.

Strong Macintosh computer aptitude, including experience with word processing and/or spreadsheet software and/or data analysis and database software.

Familiarity with standard laboratory safety procedures.

Excellent organization and time management skills.

Flexibility to handle a variety of tasks and shift priorities simultaneously.

Strong interpersonal skills; ability to effectively interact with all levels of staff and external contacts; ability to work as an effective team member.

Cooperative and service-oriented attitude; must be able to work under pressure and maintain a professional demeanor.

Ability to use sound judgment to effectively solve problems within the scope of the position.

High level of initiative and ability to work with minimum supervision.

Superior verbal and written communications skills.

HOW TO APPLY

To apply online, visit our website at http://www.tigr.org. TIGR 9712 Medical Center Dr. Rockville, MD 20850 EOE