[Next-Generation Sequencing Book]
  • [Photo] Pauline Javorski • April 19, 2006

    BACKGROUND

    VITAE PHARMACEUTICALS, INC. is an emerging pharmaceutical company dedicated to the discovery and development of innovative drugs by advancing its pipeline of product candidates in major therapeutic areas including cancer, dermatology and cardiovascular disease. Vitae is uniquely able to accelerate drug candidates by integrating the traditional drug discovery skills and intuition of proven drug developers with state-of-the-art, proprietary drug design technologies. Vitae Pharmaceuticals is financed by leading corporate and venture capital investors and is headquartered in Fort Washington, Pennsylvania.

    RESPONSIBILITIES

    As a Research Scientist in the Computational Drug Discovery group, you will help to develop and maintain the company's proprietary drug discovery technology. You will develop and implement fast and accurate methods for making predictions (such as protein-ligand binding free energies) to aid decision-making during preclinical drug discovery. You will design and code algorithms (in C++ and Java) for calculating molecular properties and simulating biological systems. You will work on Vitae's Integrated Drug Discovery System, a Java-based, three-tiered molecular data management application comprising a GUI front end, a 200+CPU compute cluster and a 200GB Oracle database.

    REQUIREMENTS

    • PhD in physical chemistry, chemical physics, physics, or biophysics from a top tier graduate program.
    • Good understanding of physics, physical chemistry, and structural biology.
    • 4+ years of independent research experience with computational simulations of biological phenomena such as protein folding or protein-ligand binding.
    Experience developing algorithms for optimization, sampling, machine learning, and/or molecular dynamics.
    • Extensive programming experience in C++ (C++ and Java preferred).
    • Strong interpersonal and communication skills (both written and verbal).
    • Experience with machine learning techniques is a plus.

    HOW TO APPLY

    If youâ??re interested in this exceptional opportunity within Vitae, please email your resume to pjavorski[at]vitaerx.com or fax to 215-461-2016 with subject line CRS-BIOINFO. You can also visit our website to learn more about us at http://www.vitaepharma.com.

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