[Next-Generation Sequencing Book]
  • [Photo] Edie Estabrook • March 4, 2009

    BACKGROUND

    Proteostasis Therapeutics, Inc. is seeking highly motivated individuals interested in applying computational and bioinformatic approaches to drug discovery.

    RESPONSIBILITIES

    The research interest is focused on developing/applying innovative data analysis capabilities to gain insights into gene networks involved in proteome homeostasis and protein mis-folding and investigate their disease relevance. High-throughput biological datasets such as microarray data, protein-protein interaction data, RNAi data will be explored and integrated. This scientist will be part of a bioinformatics team working closely with cross-discipline teams including biology and medicinal chemistry.

    REQUIREMENTS

    Recent Ph.D. in bioinformatics, computational biology, or computer science/electrical engineering with exposure to life sciences. A strong publication record is essential.
    • Proficiency in large-scale biological, "-omics" data analysis. Broad experience with microarray analysis required
    • Working knowledge of systems biology (pathways, networks, etc) and sequence analysis
    • Knowledge and experience in machine learning and data mining is preferred
    • Proficiency in R, matlab, or equivalent statistical software
    • Strong background in statistical analysis
    • Good programming skills in Java, Perl, Python or C, can independently manipulate large datasets
    • Familiarity with relational databases (SQL)
    • Good understanding of data analysis methods and experimental design
    • Highly analytical with good technical and problem solving skills
    • Excellent written and verbal communication skills

    PREFERENCES

    Postdoctoral experience or biotech/pharmaceutical industry experience is a plus.

    LOCALE: Cambridge, MA

    HOW TO APPLY

    Please send resume and cover letter to: info[at]proteostasis.com; include job code HG-BS in subject line.

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