[Next-Generation Sequencing Book]
  • [Photo] Mauro C Delorenzi • November 5, 2009

    BACKGROUND

    We are undertaking a project to characterize and biologically understand molecular heterogeneity of a specific cancer types by combining studies with multiple types of genomics and epigenomics technologies, as well as combining public and proprietary data.

    SIB (http://www.isb-sib.ch) is a not-for-profit organization that offers excellent bioinformatics infrastructure and a stimulating research environment. In addition to powerful computer hardware, the SIB branches maintain a large collection of molecular biology databases and software packages.

    The scientist will be working in a multidisciplinary team with great expertise in applications of bioinformatics and biostatistics to translational research. The project is in collaboration with the biomarker discovery unit of a major pharmaceutical company. The position will open opportunities for careers in basic or applied research in academia or in the private sector.

    RESPONSIBILITIES

    To complete the data analysis team we seek a versatile highly motivated and well-trained postdoctoral researcher with an interest in biomolecular data mining with high throughput data. In particular, the scientist will explore connections between the different molecular profiles (mRNA and miRNA expression, DNA methylation, gene mutation and CNV) and interpret the data in the contest of biochemical signaling pathways and their relevance to tumor growth and progression.

    Job Tasks:
    • Integration of molecular profile data with prior biological knowledge (biological function and pathway databases, role in diseases)
    • Biological interpretation to make sense out of results from data analyses of large bodies of complex data
    • Interrogate data with plots, data mining techniques and statistical analysis in collaboration with statisticians and molecular biologists to find patterns, generate hypothesis and propose ways to validate them

    REQUIREMENTS

    • PhD, e.g. in bioinformatics, biology, pharmacy, biochemistry or related fields
    • Good knowledge of cancer biology and cell biochemistry
    • Enthusiastic interest for research at the crossroads of experimental and computation methods and of basis and clinical research
    • Excellent interpersonal skills for working within a team of biologists and programmers
    • High-level understanding of bioinformatics and statistics methods
    • Good English speaking and writing skills

    PREFERENCES

    • Preference will be given to candidates who have excellent written and oral communication skills, an in depth understanding of the biological questions, and are good team players.
    • Experience with genomic databases and with software tools for exploration of biochemical pathway activity (Partek, Ingenuity/MetaCore, Genome Studio or the like)
    • Experience in the analysis of high-throughput genomic / genetic data, particularly the interpretation of molecular profile or genotype data
    • Knowledge of biological pathways-regulation principles and mechanisms
    • Solid background in Computer Science, Engineering, Mathematics, Physics, Bioinformatics or related quantitative sciences

    TERMS

    Full-time position, starting immediately or upon agreement

    LOCALE

    Working place is Swiss Institute of Bioinformatics in Lausanne, Switzerland Lausanne [http://www.lausanne.ch] is a beautiful lakeside city in Switzerland close at the border of the Alps.

    COMPENSATION

    Salary: 75 - 100 k Swiss francs (50 - 70 k eurodollars) per year, depending on experience and qualifications. SIB offers an attractive social security system.

    HOW TO APPLY

    The application should include a cover letter, with summary of motivation, research interests and past accomplishments; curriculum vitae including description of skills and experiences; names and email addresses of at least three referees. Please also indicate if you are already authorized to work in Switzerland or the EU (visa).

    Applications should be sent by mail with Subject line: "Application Biomarkers BCF-November2009" to Mauro.delorenzi[at]isb-sib.ch (Head BCF [bcf.isb-sib.ch], Swiss Institute of Bioinformatics, Quartier Sorge - Batiment Genopode, CH-1015 Lausanne).

    DEADLINE

    Position is currently vacant and will be occupied as soon as possible.

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