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BACKGROUND

The Institute for Systems Biology (ISB) is an internationally renowned non-profit research institute dedicated to the study and application of systems biology. Founded in 2000 in Seattle, Washington, ISB�s goal is to unravel the mysteries of cellular networks and identify strategies that will usher in a new era of P4 Medicine (predictive, preventive, participatory and personalized medicine).

RESPONSIBILITIES

ISB is seeking a bioinformatics scientist for a multi-institution project which aims to uncover the mechanisms underlying AIDS vaccine immunogenicity. This project, funded by the Bill and Melinda Gates Foundation, employs systems biology and gene expression microarray approaches to identify novel genes and pathways which, when activated, lead to enhanced vaccine-induced immune responses.

This individual will be responsible for analyzing gene expression microarray and immunological datasets collected by our collaborators for human and NHP responses to model vaccines. A primary focus will be integrating the microarray data with the immunological measurements (such as percentage of antigen-specific responding CD8+ T-cells) to identify gene expression signatures for enhanced immune responses. Additional efforts will focus on identifying gene expression signatures that are consistent across vaccine models and experimental model systems, and interpreting the biological significance of the signatures.

Duties:

The individual will be expected to perform analysis in a transparent manner and to clearly communicate analysis results to collaborating scientists.
The individual will also be expected to develop tools and facilities to make data and analysis results easily accessible to other scientists.
Finally, the individual is expected to take an active interest in the biology and to interpret analysis results in a biological context.

REQUIREMENTS

Applicants must hold an MS or Ph.D. degree in Bioinformatics, Biology, Engineering, Physics, Computer Science, Mathematics, or a related scientific discipline pertinent to the position.
Some experience working with microarrays or complex biological datasets is required, as is fluency with basic statistical methods.
Applicants must also have experience with computational analysis frameworks such as R or MATLAB.
While a strong background in Immunology is not required for this position, enthusiasm and interest in Immunology is required.
We are seeking an individual who will independently dive into the biological literature to gain then necessary background knowledge as needed for the project.

PREFERENCES

Familiarity with bioinformatics tools like Bioconductor and Cytoscape is a bonus.

LOCALE: Seattle, WA

SALARY & COMPENSATION

Fully benefitted position (health care, 403b, etc.)

HOW TO APPLY

Please visit the Careers page of our website at http://www.systemsbiology.org/careers for application instructions. Please include Job # 09-093 in all correspondence regarding this position.

ISB is an M/F/D/V/EOE.

DEADLINE: January 31, 2010

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